Details of the Drug

General Information of Drug (ID: DM6NIZD)

Drug Name
Gilotrif
Synonyms
Afatinib dimaleate; AFATINIB DIMALEATE; 850140-73-7; Afatinib (diMaleate); UNII-V1T5K7RZ0B; BIBW 2992MA2; Afatinib dimaleate [USAN]; V1T5K7RZ0B; CHEBI:76003; Afatinib (BIBW2992) Dimaleate; Afatinib maleate; Afatinib dimaleate (USAN); Giotrif; Gilotrif (TN); Giotrif (TN); Afatinib maleate (JAN); (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate); BIBW2992 MA2; CHEMBL2105712; USNRYVNRPYXCSP-JUGPPOIOSA-N; MolPort-028-744-902; AOB873
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Squamous cell carcinoma 2B60-2D01 Phase 3 [1]
Glioma 2A00.0 Phase 2 [1]
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C32H33ClFN5O11
Canonical SMILES
CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
InChI
InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1
InChIKey
USNRYVNRPYXCSP-JUGPPOIOSA-N
Cross-matching ID
PubChem CID
15606394
ChEBI ID
CHEMBL2105712
CAS Number
850140-73-7
TTD ID
D0BD9K
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)