Details of the Drug

General Information of Drug (ID: DM6NZ2P)

Drug Name
Pegvaliase
Synonyms BMN 165; Pegvaliase [INN]; UNII-N6UAH27EUV; N6UAH27EUV
Indication
Disease Entry ICD 11 Status REF
Phenylketonuria 5C50.0 Approved [1]
ATC Code
A16AB19: Pegvaliase
A16AB: Enzymes
A16A: OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16: OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A: ALIMENTARY TRACT AND METABOLISM
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 318.41
Logarithm of the Partition Coefficient (xlogp) -2.3
Rotatable Bond Count (rotbonds) 15
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 14.0 +/- 16.3 mg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 8 h []
Clearance
The clearance of drug is 0.39 +/- 0.87 L/h []
Half-life
The concentration or amount of drug in body reduced by one-half in 14 - 132 hours []
Vd
The volume of distribution (Vd) of drug is 26.4 +/- 64.8 L []
Chemical Identifiers
Formula
C15H30N2O5
IUPAC Name
(2S)-2-amino-6-[6-(2-methoxyethoxy)hexanoylamino]hexanoic acid
Canonical SMILES
COCCOCCCCCC(=O)NCCCC[C@@H](C(=O)O)N
InChI
InChI=1S/C15H30N2O5/c1-21-11-12-22-10-6-2-3-8-14(18)17-9-5-4-7-13(16)15(19)20/h13H,2-12,16H2,1H3,(H,17,18)(H,19,20)/t13-/m0/s1
InChIKey
NPOCDVAOUKODSQ-ZDUSSCGKSA-N
Cross-matching ID
PubChem CID
86278362
CAS Number
1585984-95-7
UNII
N6UAH27EUV
DrugBank ID
DB12839
TTD ID
D0T8HZ
ACDINA ID
D01326
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phenylalanine hydroxylase (PAH) TTGSVH2 PH4H_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium chloride E00077 5234 Diluent; Tonicity agent
Tromethamine E00125 6503 Alkalizing agent; Buffering agent; Emulsifying agent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Pegvaliase 10mg/0.5 ml Injection 10mg/0.5 ml Injection Intravenous
Pegvaliase 2.5mg/0.5 ml Injection 2.5mg/0.5 ml Injection Intravenous
Pegvaliase 20 mg/ml Injection 20 mg/ml Injection Intravenous
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Induction, titration, and maintenance dosing regimen in a phase 2 study of pegvaliase for control of blood phenylalanine in adults with phenylketonuria.Mol Genet Metab. 2018 Nov;125(3):217-227.