Details of the Drug

General Information of Drug (ID: DM6P1UA)

Drug Name
JNJ-10191584
Synonyms VUF 6002; JNJ 10191584; VUF6002; VUF-6002; JNJ10191584; compound 12
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 278.74
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C13H15ClN4O
IUPAC Name
(6-chloro-1H-benzimidazol-2-yl)-(4-methylpiperazin-1-yl)methanone
Canonical SMILES
CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl
InChI
InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)
InChIKey
MOIWSUQWIOVGRH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10446295
ChEBI ID
CHEBI:92272
CAS Number
73903-17-0
TTD ID
D00XJR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H4 receptor (H4R) TTXJ178 HRH4_HUMAN Antagonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H4 receptor (H4R) DTT HRH4 1.32E-01 0.1 0.9
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 7.8863 10.4268 4.3523 1.5517
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 7.3845 9.6928 4.417 1.7804
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.606 7.9143 4.7688 0.7783
LN-229 CTRP1 7.1195 8.8863 4.6156 1.021
GaMG CTRP1 7.7028 8.9495 4.8127 0.0994
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP1 6.7044 12.6442 2.6523 15.916
HEC-265 CTRP1 6.8031 7.6859 4.9272 0.1077
HEC-59 CTRP1 7.0129 8.3671 4.7659 0.4597
MFE-319 CTRP1 7.1767 8.7216 4.701 0.594
KLE CTRP1 7.2748 9.3201 4.515 1.3718
HEC-108 CTRP1 7.3607 8.3744 4.8875 0.0619
JHUEM-2 CTRP1 7.3707 9.2905 4.5678 1.0095
HEC-251 CTRP1 7.4158 8.9565 4.7085 0.4216
HEC-6 CTRP1 7.5906 8.8293 4.8146 0.117
Ishikawa (Heraklio) 02 ER- CTRP1 6.6513 7.8211 4.823 0.4907
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 1.1063 105.0104 -48.1502 50.3187
WSU-DLCL2 CTRP1 5.947 8.3874 4.1852 6.5744
PL21 CTRP1 6.4272 9.2613 4.0861 6.0239
MC116 CTRP1 6.4758 7.1991 4.9778 0.0993
SKM-1 CTRP1 6.5015 7.8024 4.7666 0.9036
SU-DHL-5 CTRP1 6.5183 8.0211 4.6867 1.3445
THP-1 CTRP1 6.6503 11.2449 3.2917 11.6306
NOMO-1 CTRP1 6.6642 8.4577 4.5778 1.8128
BL-70 CTRP1 6.741 7.8491 4.8479 0.3377
GDM-1 CTRP1 6.7446 9.8908 3.9907 5.9688
U-937 CTRP1 6.9189 8.7921 4.563 1.5378
LP-1 CTRP1 6.9645 8.6048 4.6573 0.9703
OCI-Ly10 CTRP1 6.9968 11.5239 3.3886 9.9103
SU-DHL-4 CTRP1 7.0355 8.7806 4.62 1.0849
AMO1 CTRP1 7.0413 8.2998 4.8009 0.3274
HT CTRP1 7.2226 8.3606 4.8452 0.1502
RPMI-8226 CTRP1 7.2997 9.1372 4.5961 0.9428
EJM CTRP1 7.4 9.4538 4.5177 1.2232
P3HR-1 CTRP1 7.4014 8.9143 4.7181 0.3994
Ku812 CTRP1 7.5045 9.1346 4.6786 0.47
MOLM-16 CTRP1 7.5651 10.061 4.3528 1.9173
KMS-11 CTRP1 7.6245 17.4305 0.976 21.9491
KE-97 CTRP1 8.0441 9.4148 4.7737 0.0943
OCI-AML-3 CTRP1 8.2044 20.608 -0.159 24.6327
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP1 7.1549 8.5764 4.7452 0.446
VMRC-RCW CTRP1 7.4285 9.0568 4.6775 0.5171
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320 CTRP1 5.9953 10.5546 3.1602 14.7743
HCT 8 CTRP1 6.292 7.6042 4.7486 1.29
GP2d CTRP1 6.3027 7.958 4.6038 2.2654
HT-55 CTRP1 6.6941 7.8773 4.8194 0.4735
MDST8 CTRP1 6.7675 8.7154 4.5216 2.0147
RCM-1 [Human ESC] CTRP1 6.7707 9.0545 4.3793 2.981
COLO205 CTRP1 6.7835 8.2825 4.7034 0.9247
SNU-C4 CTRP1 6.845 7.8921 4.8715 0.2166
LS513 CTRP1 6.8613 8.3142 4.7245 0.7464
SW948 CTRP1 6.8987 8.3196 4.7379 0.6542
DLD-1 CTRP1 6.899 8.1335 4.8063 0.3872
SK-CO-1 CTRP1 6.9154 8.495 4.6784 0.9152
SW48 CTRP1 6.9557 9.329 4.3585 2.7899
SW403 CTRP1 6.9973 10.8698 3.6942 7.618
HT115 CTRP1 7.0325 8.6796 4.6576 0.9018
SNU-61 CTRP1 7.0438 8.7658 4.6294 1.0289
SNU-1040 CTRP1 7.0499 8.372 4.7784 0.3944
LS411N CTRP1 7.087 8.3823 4.7888 0.3415
NCI-H508 CTRP1 7.0914 9.9852 4.1476 4.0185
LS180 CTRP1 7.1026 8.6341 4.7037 0.6376
LS123 CTRP1 7.1638 9.5899 4.3538 2.4765
SW620 CTRP1 7.2654 11.5811 3.5303 8.1655
CW-2 CTRP1 7.2762 9.3733 4.4947 1.4794
HCT 116 CTRP1 7.3266 9.1058 4.6191 0.8169
CL-34 CTRP1 7.3326 9.0627 4.6375 0.7341
C2BBe1 CTRP1 7.4884 9.1705 4.6596 0.5434
LoVo CTRP1 7.5212 9.8913 4.4003 1.7063
CL-40 CTRP1 7.5808 8.9574 4.7681 0.201
RKO CTRP1 7.6119 10.9444 4.01 3.9994
COLO 678 CTRP1 7.6377 10.3041 4.2889 2.1911
SNU-C5 CTRP1 7.6458 9.6528 4.5451 0.8756
SNU-C2A CTRP1 7.7181 9.9562 4.4609 1.1882
HT-29 CTRP1 7.7706 18.2754 0.6684 22.7982
SNU-81 CTRP1 7.8146 9.4371 4.6868 0.3053
KM12 CTRP1 7.8392 9.3742 4.7172 0.2287
SNU-175 CTRP1 7.8922 16.2917 1.7133 17.8121
SW480 CTRP1 8.3091 11.1335 4.2621 1.5703
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.3661 7.147 4.9563 0.1923
Hep-G2 CTRP1 6.8391 8.5251 4.633 1.2379
SNU-398 CTRP1 7.4416 9.0221 4.6949 0.4514
SNU-449 CTRP1 8.8078 15.7387 2.5554 10.9571
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1930 CTRP1 5.579 8.6184 3.8023 11.1373
NCI-H1105 CTRP1 6.2362 9.7144 3.7447 9.3681
NCI-H1694 CTRP1 6.2675 7.7897 4.6578 1.9449
SCLC-21H CTRP1 6.3509 8.0776 4.5778 2.3598
BEN CTRP1 6.3826 7.4891 4.8364 0.6683
DV-90 CTRP1 6.4568 9.013 4.2193 4.8781
NCI-H1781 CTRP1 6.4925 8.1246 4.6313 1.7363
NCI-H1836 CTRP1 6.5716 10.3404 3.671 8.9517
NCI-H2073 CTRP1 6.5984 9.1358 4.2474 4.3215
NCI-H82 CTRP1 6.6861 8.2253 4.6826 1.1474
HCC2108 CTRP1 6.6938 8.6584 4.5085 2.2224
NCI-H1048 CTRP1 6.7047 8.8264 4.4426 2.6569
LC-1/sq-SF CTRP1 6.7069 8.0611 4.7557 0.7431
T3M-10 CTRP1 6.7173 8.9203 4.4088 2.8717
NCI-H2081 CTRP1 6.7596 8.9062 4.4371 2.5958
LCLC-97TM1 CTRP1 6.7757 11.6327 3.1907 11.9939
HCC2935 CTRP1 6.7926 8.6057 4.579 1.6146
HCC4006 CTRP1 6.796 8.9929 4.419 2.6561
HCC827 CTRP1 6.8129 8.4444 4.6531 1.1582
HCC1359 CTRP1 6.8143 7.7409 4.9125 0.1325
NCI-H1435 CTRP1 6.8426 9.043 4.4218 2.555
NCI-H441 CTRP1 6.8825 8.9626 4.4756 2.1315
NCI-H460 CTRP1 6.8843 8.4457 4.684 0.9186
NCI-H2122 CTRP1 6.8979 8.6303 4.6179 1.2511
NCI-H841 CTRP1 6.9043 12.685 2.7725 14.5076
NCI-H1573 CTRP1 6.9106 8.8645 4.5297 1.7487
NCI-H2029 CTRP1 6.926 8.2369 4.7793 0.4668
SHP-77 CTRP1 6.9424 12.7368 2.7738 14.3835
NCI-H596 CTRP1 6.9435 8.8495 4.5513 1.574
Sq-1 CTRP1 6.9686 8.6784 4.6305 1.1028
LXF 289 CTRP1 6.9917 9.6083 4.2576 3.4265
NCI-H3255 CTRP1 6.9965 8.7891 4.5995 1.2357
NCI-H1792 CTRP1 7.0236 9.3568 4.3813 2.5216
NCI-H2126 CTRP1 7.0814 8.3781 4.7882 0.3462
A-549 CTRP1 7.0901 9.5861 4.3185 2.8297
LCLC-103H CTRP1 7.0973 8.2449 4.8404 0.1983
NCI-H810 CTRP1 7.1035 8.4766 4.7614 0.4209
NCI-H1915 CTRP1 7.1158 8.9476 4.5902 1.1524
NCI-H727 CTRP1 7.1352 9.5165 4.3703 2.4153
Lu-65 CTRP1 7.1438 8.9963 4.5836 1.1567
HCC33 CTRP1 7.1484 8.8905 4.6262 0.9414
SK-LU-1 CTRP1 7.1922 9.2391 4.5099 1.4958
NCI-H522 CTRP1 7.1989 8.7491 4.6997 0.5837
NCI-H1568 CTRP1 7.2005 11.0313 3.7428 6.7565
NCI-H2009 CTRP1 7.2046 9.4122 4.4463 1.8444
NCI-H1876 CTRP1 7.2242 8.8156 4.6854 0.6216
DMS 273 CTRP1 7.2249 9.0214 4.6087 0.9528
NCI-H1666 CTRP1 7.255 10.5654 3.9829 4.8738
NCI-H1975 CTRP1 7.2608 8.9969 4.6328 0.8116
Lu-99 CTRP1 7.2812 8.5885 4.7879 0.2575
Calu-3 CTRP1 7.2825 8.9334 4.6653 0.6591
COR-L23 CTRP1 7.2914 8.7927 4.7198 0.453
NCI-H650 CTRP1 7.3051 8.8336 4.7104 0.4768
COLO 699 CTRP1 7.404 10.0631 4.2757 2.6034
CAL-12T CTRP1 7.4109 9.4201 4.5353 1.1259
COR-L51 CTRP1 7.423 9.0245 4.687 0.4879
NCI-H2030 CTRP1 7.4271 10.4833 4.1109 3.6464
NCI-H2141 CTRP1 7.4403 9.0666 4.6785 0.5067
NCI-H1755 CTRP1 7.4477 9.1919 4.6359 0.6568
NCI-H1437 CTRP1 7.4515 8.9399 4.7277 0.3471
Calu-6 CTRP1 7.4596 9.0774 4.6819 0.4839
COR-L88 CTRP1 7.4629 9.2484 4.6212 0.7033
HCC1195 CTRP1 7.4664 8.8388 4.7682 0.2373
HCC15 CTRP1 7.5309 11.6931 3.6369 6.7701
NCI-H2286 CTRP1 7.531 8.6603 4.8504 0.0798
NCI-H2172 CTRP1 7.5672 9.0825 4.7202 0.3175
NCI-H1373 CTRP1 7.5985 9.3628 4.6326 0.5709
NCI-H1963 CTRP1 7.6142 9.6159 4.546 0.8971
COR-L279 CTRP1 7.6147 8.9832 4.7712 0.1852
NCI-H358 CTRP1 7.6659 9.3912 4.6482 0.4807
RERF-LC-KJ CTRP1 7.6763 9.053 4.7691 0.1729
NCI-H1944 CTRP1 7.6771 9.7063 4.5379 0.8812
HCC78 CTRP1 7.6836 9.4241 4.6432 0.4872
COLO 668 CTRP1 7.7161 9.7164 4.5499 0.8028
NCI-H1793 CTRP1 7.7198 9.2773 4.7079 0.2892
EBC-1 CTRP1 7.7255 9.4414 4.6527 0.4363
NCI-H2023 CTRP1 7.7525 9.6273 4.5966 0.6035
NCI-H2405 CTRP1 7.7594 10.7975 4.1458 2.8804
NCI-H1299 CTRP1 7.8027 9.6339 4.6134 0.5186
EPLC-272H CTRP1 7.8089 9.9354 4.5062 0.911
KNS-62 CTRP1 7.8245 9.2779 4.7446 0.1796
NCI-H2110 CTRP1 7.8348 11.8581 3.7341 5.4572
NCI-H2342 CTRP1 7.8494 10.3356 4.3716 1.4932
HARA [Human squamous cell lung carcinoma] CTRP1 7.9232 9.4878 4.708 0.2226
NCI-H661 CTRP1 7.9444 9.8331 4.5959 0.4994
VMRC-LCD CTRP1 7.9791 9.5842 4.6949 0.2329
NCI-H23 CTRP1 7.9885 9.9566 4.5687 0.5621
HCC1833 CTRP1 8.0871 10.1177 4.5486 0.5737
HCC44 CTRP1 8.1067 9.8335 4.6549 0.2778
NCI-H1355 CTRP1 8.2395 10.1763 4.5844 0.3983
ChaGo-K-1 CTRP1 8.3009 10.2081 4.5956 0.347
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-410 CTRP1 7.0732 9.0436 4.5334 1.5099
KYSE-140 CTRP1 7.2448 9.3173 4.5027 1.4727
KYSE-450 CTRP1 7.5269 8.7319 4.8253 0.1137
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OAW42 CTRP1 6.2054 7.5879 4.7118 1.6794
JHOM-1 CTRP1 6.4852 8.23 4.5831 2.0734
OVKATE CTRP1 6.6098 13.2106 2.3074 18.3573
JHOC-5 CTRP1 6.8136 8.8003 4.5091 2.0227
COV318 CTRP1 6.8355 7.7619 4.9128 0.1259
EFO-21 CTRP1 7.108 8.4909 4.758 0.4299
SK-OV-3 CTRP1 7.1607 8.7464 4.6854 0.6681
IGROV-1 CTRP1 7.1786 9.761 4.2896 2.8731
OVMANA CTRP1 7.2227 8.4539 4.8134 0.2173
HEY A8 CTRP1 7.2634 8.491 4.8152 0.1996
COV362 CTRP1 7.2651 9.0177 4.6268 0.8345
EFO-27 CTRP1 7.2931 9.1728 4.5798 1.0253
COV434 CTRP1 7.3145 9.6553 4.3996 1.973
OVCAR-4 CTRP1 7.3257 12.3849 3.1947 10.4202
OVCAR-8 CTRP1 7.3267 11.432 3.6355 7.2487
COV644 CTRP1 7.3283 9.4637 4.4824 1.4853
JHOS-4 CTRP1 7.4319 9.0545 4.6796 0.5079
RMG-I CTRP1 7.5139 14.9357 2.1069 16.7651
OV7 CTRP1 7.5418 9.3597 4.6116 0.6849
Caov-3 CTRP1 7.6391 9.4522 4.616 0.6046
SNU-840 CTRP1 7.7224 11.1386 3.9846 3.9754
A2780 CTRP1 7.8023 9.7549 4.5698 0.668
OV-90 CTRP1 8.123 9.673 4.7148 0.1608
RMUG-S CTRP1 8.1542 15.9108 2.0689 15.2588
TYK-nu CTRP1 8.2319 14.5992 2.7305 11.2147
OVK18 CTRP1 9.6449 20.806 0.7252 18.0611
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 CTRP1 7.0198 8.5672 4.6949 0.7415
QGP-1 CTRP1 7.1022 8.8518 4.6214 1.0096
HPAC CTRP1 7.1734 8.7759 4.6796 0.6823
PaTu 8902 CTRP1 7.2271 8.4538 4.815 0.2121
Capan-2 CTRP1 7.2836 11.1057 3.758 6.4516
SUIT-2 CTRP1 7.4703 8.7439 4.8019 0.1658
HuP-T4 CTRP1 7.6941 9.2911 4.6939 0.3347
KP-3 CTRP1 7.774 10.979 4.0778 3.2843
CFPAC-1 CTRP1 7.8067 9.7891 4.5591 0.7044
Panc 10.05 CTRP1 8.2634 10.1481 4.6028 0.3433
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP1 6.8125 9.9376 4.0101 5.6537
MSTO-211H CTRP1 7.4228 9.4447 4.531 1.1352
NCI-H2052 CTRP1 7.9472 9.8559 4.5889 0.5197
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 7.0372 8.2312 4.8235 0.2642
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 CTRP1 5.9347 9.7026 3.5349 12.0743
A-375 CTRP1 6.5218 9.2953 4.129 5.4345
Hs 936.T CTRP1 6.9986 10.118 4.0372 5.0214
G-361 CTRP1 7.2026 8.9913 4.6107 0.9639
SK-MEL-1 CTRP1 7.2219 8.3069 4.863 0.1188
Hs 852.T CTRP1 7.2822 8.7672 4.7254 0.4395
Hs 944.T CTRP1 7.3282 8.9234 4.6869 0.5456
COLO 741 CTRP1 7.3706 9.0815 4.6458 0.6724
SK-MEL-5 CTRP1 7.3862 8.6155 4.816 0.1617
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1080 CTRP1 6.7904 8.1758 4.7472 0.7058
RKN CTRP1 7.2243 8.3288 4.8565 0.1293
G-401 CTRP1 7.2298 10.3193 4.0769 4.2501
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 CTRP1 6.6308 9.247 4.2161 4.4887
MKN74 CTRP1 7.1926 9.5752 4.3741 2.303
NUGC-4 CTRP1 7.37 9.005 4.6736 0.5673
AGS CTRP1 7.383 8.8071 4.7489 0.3182
SH-10-TC CTRP1 7.6614 8.8498 4.8316 0.0826
MKN7 CTRP1 7.9528 9.5612 4.6935 0.2437
SNG-M CTRP1 7.8874 9.674 4.6309 0.4233
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.9675 8.1597 4.8228 0.2977
SCC-9 CTRP1 7.301 9.1133 4.6057 0.8979
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 CTRP1 7.4237 11.1095 3.8364 5.575
5637 CTRP1 7.7361 9.7454 4.5472 0.799
UM-UC-3 CTRP1 7.8243 9.3047 4.7355 0.1965
HT-1376 CTRP1 7.9141 9.8723 4.5705 0.5977
KMBC-2 CTRP1 7.9876 9.7072 4.6558 0.3167

References

1 Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98.
2 Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5251-6.