Details of the Drug

General Information of Drug (ID: DM74ZKN)

Drug Name
HBI-3000
Synonyms Sulcardine; Multi-ion channel blocker (oral, arrhythmia), SIMM; Multi-ion channel blocker (oral/iv, arrhythmia), HUYA
Indication
Disease Entry ICD 11 Status REF
Heart arrhythmia BC65 Phase 2 [1]
Atrial fibrillation BC81.3 Phase 1 [2]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
16043221
TTD ID
D02SVQ
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium channel unspecific (CaC) TT5HONZ NOUNIPROTAC Blocker [3]
Potassium channel unspecific (KC) TT1VOHK NOUNIPROTAC Blocker [3]
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01235156) Efficacy and Safety of Sulcardine Sulfate Tablets in Patients With Premature Ventricular Contractions. U.S. National Institutes of Health.
2 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
3 Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85.