Details of the Drug

General Information of Drug (ID: DM77XQT)

Drug Name

NFX-179

Synonyms

Nedometinib; NFX-179; K5T4I78IYZ; 2252314-46-6; 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 2-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo(2,3-b)pyridine-3-carboxamide; UNII-K5T4I78IYZ; NFX179; SCHEMBL21979494; GTPL12872; Example 2 [US11161845B2]; HY-156625; CS-0886460; EN300-27122249; 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methylpyrrolo[2,3-b]pyridine-3-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Neurofibromatosis 1	LD2D.10	Phase 2	[1]

Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C17H16FIN4O3
Canonical SMILES: CN1C2=C(C=CC=N2)C(=C1NC3=C(C=C(C=C3)I)F)C(=O)NOCCO
InChI: InChI=1S/C17H16FIN4O3/c1-23-15-11(3-2-6-20-15)14(17(25)22-26-8-7-24)16(23)21-13-5-4-10(19)9-12(13)18/h2-6,9,21,24H,7-8H2,1H3,(H,22,25)
InChIKey: SENAOZROGSYRTD-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 146585168
UNII: K5T4I78IYZ
DrugBank ID: DB18102
TTD ID: DHM3X5

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ERK activator kinase (MEK)	TTZCRP3	NOUNIPROTAC	Inhibitor	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04435665) A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Phase 2a Study to Determine Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Activity of NFX-179 Gel in Subjects With Cutaneous Neurofibromas. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of NFlection Therapeutics