Details of the Drug

General Information of Drug (ID: DM7A4QE)

• Drug Name: Baxdrostat
• Synonyms: Baxdrostat; Baxdrostat [INN]; NF3P9Z8J5Y; 1428652-17-8; UNII-NF3P9Z8J5Y; (+)-(R)-N-(4-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide; N-((8R)-5,6,7,8-Tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl)propanamide; Propanamide, N-((8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl)-; CIN107; CHEMBL4113975; SCHEMBL14799753; GTPL12362; CIN-107; BDBM233806; GLXC-26998; MS-25786; HY-132809; RO6836191; CS-0204056; US9353081, 3-1; N-[(8R)-4-(1-methyl-2-oxo-3,4-dihydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Phase 2	[1]

• Drug Type: Small molecule
• Chemical Identifiers:
  Formula: C22H25N3O2
  Canonical SMILES: CCC(=O)NC1CCCC2=C1C=NC=C2C3=CC4=C(C=C3)N(C(=O)CC4)C
  InChI: InChI=1S/C22H25N3O2/c1-3-21(26)24-19-6-4-5-16-17(12-23-13-18(16)19)14-7-9-20-15(11-14)8-10-22(27)25(20)2/h7,9,11-13,19H,3-6,8,10H2,1-2H3,(H,24,26)/t19-/m1/s1
  InChIKey: VDEUDSRUMNAXJG-LJQANCHMSA-N
• Cross-matching ID:
  PubChem CID: 71535962
  ChEBI ID: CHEMBL4113975
  TTD ID: D8FHG5
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldosterone synthase (CYP11B2)	TT9MNE2	C11B2_HUMAN	Inhibitor	[2]

References

• [1] Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2023 Feb 2;388(5):395-405.
• [2] Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2023 Feb 2;388(5):395-405.