Details of the Drug

General Information of Drug (ID: DM7K5GD)

• Drug Name: Lutropin alfa
• Synonyms: Luveris; Luveris (TN); Lutropin alfa (USAN/INN)

Indication

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Approved	[1]

• Therapeutic Class: Fertility Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  G03GA07: Lutropin alfa
  G03GA: Gonadotropins
  G03G: GONADOTROPINS AND OTHER OVULATION STIMULANTS
  G03: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
  G: GENITO URINARY SYSTEM AND SEX HORMONES
• Sequence:
  >Alpha chain
  APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCC
  VAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
  >Beta chain
  SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYR
  DVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLF
  L
• ADMET Property:
  Half-life: The concentration or amount of drug in body reduced by one-half in 18 hours [2]
  Metabolism: The drug is metabolized via renal []
  Vd: The volume of distribution (Vd) of drug is 10-14 L []
• Cross-matching ID:
  UNII: 3JGY52XJNA
  DrugBank ID: DB00044
  TTD ID: D0Z2CM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Binder	[3]

Molecular Expression Atlas of This Drug

• The Studied Disease: Female infertility
• ICD Disease Classification: GA31.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	3.55E-01	5.41E-04	4.54E-03

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [3] Lutropin alfa. Drugs. 2008;68(11):1529-40.