Details of the Drug

General Information of Drug (ID: DM7QGHO)

Drug Name
AZD5991
Synonyms KBQCEQAXHPIRTF-UHFFFAOYSA-N; AZD-5991 (Racemate); 2143061-81-6; UNII-E3T5XXY9HX; E3T5XXY9HX; SCHEMBL19472011; EX-A2673; HY-101533A; CS-0077938; E4W
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 672.3
Logarithm of the Partition Coefficient (xlogp) 6.8
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C35H34ClN5O3S2
IUPAC Name
17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid
Canonical SMILES
CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C
InChI
InChI=1S/C35H34ClN5O3S2/c1-20-31-29(38-40(20)3)19-45-17-22-15-23(41(4)37-22)18-46-24-14-21-8-5-6-9-25(21)30(16-24)44-13-7-10-26-27-11-12-28(36)32(31)33(27)39(2)34(26)35(42)43/h5-6,8-9,11-12,14-16H,7,10,13,17-19H2,1-4H3,(H,42,43)
InChIKey
KBQCEQAXHPIRTF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
131634760
CAS Number
2143061-82-7
UNII
E3T5XXY9HX
DrugBank ID
DB14792
TTD ID
D06XCP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) TTL53M6 MCL1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
E3 ubiquitin-protein ligase HUWE1 (HUWE1) OTFH6BJS HUWE1_HUMAN Gene/Protein Processing [2]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Post-Translational Modifications [2]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [2]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [2]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Gene/Protein Processing [2]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) OTCDAVBQ SHIP2_HUMAN Gene/Protein Processing [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Haematological malignancy
ICD Disease Classification 2B33.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DTT MCL1 1.06E-04 1.29 2.97
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 -0.7715 8.6484 -3.2189 45.342
ESO-26 GDSC2 1.9129 5.0338 1.1248 18.6015
FLO-1 GDSC2 3.6729 6.93 1.8014 8.6401
KYAE-1 GDSC2 4.6725 6.3209 2.7424 1.1514
KYSE-50 GDSC2 4.6738 8.6105 1.7017 6.8974
OACP4 C GDSC2 4.8068 6.95 2.5448 1.9318
ESO-51 GDSC2 5.8712 7.7075 2.7231 0.3879
KYSE-220 GDSC2 5.9941 7.9052 2.6991 0.3952
SK-GT-4 GDSC2 6.3004 8.5095 2.5994 0.5085
TE-12 GDSC2 6.3459 9.026 2.4264 0.9849
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 2.4619 6.5826 0.9291 17.7051
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC2 -1.7255 2.5168 -1.9893 50.5594
Kelly GDSC2 -0.5617 1.7732 -0.6153 39.2103
NB69 GDSC2 1.1245 11.1728 -2.5574 36.4372
SJNB-14 GDSC2 1.5809 4.1002 1.1643 19.7418
SK-N-AS GDSC2 1.6205 6.9618 -0.0563 26.1093
TGW GDSC2 2.227 7.135 0.4405 21.2793
IMR-5 GDSC2 2.2575 5.3829 1.3102 16.1845
GOTO GDSC2 2.9576 7.7615 0.7916 16.8423
NB(TU)1 GDSC2 3.3253 6.6214 1.675 10.398
SK-N-DZ GDSC2 3.6146 15.1851 -2.3675 28.1377
SJNB-13 GDSC2 3.8366 5.8094 2.4766 4.0284
NH-12 GDSC2 4.0988 6.3716 2.3858 4.0119
SJNB-10 GDSC2 4.103 5.9657 2.5805 2.8502
CHP-134 GDSC2 4.1155 6.7564 2.2126 5.0226
SJNB-7 GDSC2 4.3895 9.3406 1.1493 10.777
SK-N-BE(2)-M17 GDSC2 4.5445 6.5147 2.5925 2.0494
KP-N-YN GDSC2 5.3974 7.3285 2.6722 0.7946
SiMa GDSC2 5.5748 7.6592 2.6212 0.8469
GI-ME-N GDSC2 5.7329 7.9983 2.5587 0.953
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.4987 7.1396 2.282 3.8454
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-PN-DW GDSC2 -3.4319 1.0041 -3.5695 64.7193
EW-3 GDSC2 -2.1114 3.9275 -2.7835 53.2514
ES5 GDSC2 -1.7743 2.6406 -2.0695 50.9643
NOS-1 [Human HNSCC] GDSC2 -1.4335 3.8836 -2.0314 48.2372
EW-18 GDSC2 -1.2426 1.6682 -1.3245 45.9989
ES7 GDSC2 -1.0384 3.7242 -1.5523 44.9071
HuO9 GDSC2 -0.7658 3.3202 -1.1387 42.2103
SK-ES-1 GDSC2 1.8049 8.1461 -0.4474 27.1649
CAL-78 GDSC2 2.5006 11.2163 -1.329 28.1408
EW-11 GDSC2 2.7451 7.6713 0.6496 18.3357
EW-22 GDSC2 3.1251 9.1374 0.2486 19.2758
HOS GDSC2 3.4381 6.8212 1.6681 10.1158
CADO-ES1 GDSC2 3.8875 10.7081 0.0889 17.8532
CAL-72 GDSC2 4.0102 6.7822 2.1264 5.7846
TC-71 GDSC2 4.0189 7.3372 1.8614 7.3947
G-292 clone A141B1 GDSC2 4.0935 7.0507 2.0549 6.0331
SaOS-2 GDSC2 4.0954 9.2437 0.9783 12.497
MG-63 GDSC2 4.1384 6.223 2.4823 3.3578
NY GDSC2 4.3543 9.7159 0.9392 12.0685
A-673 GDSC2 4.7309 9.5053 1.3111 9.0551
ES8 GDSC2 5.0257 7.8878 2.2539 3.1265
U2OS GDSC2 5.0258 7.3255 2.4984 1.8826
CHSA8926 GDSC2 5.4084 17.9873 -2.3528 23.6962
EW-24 GDSC2 5.4651 15.2769 -0.9772 18.7034
MHH-ES-1 GDSC2 5.5003 9.2611 1.9112 4.2268
HuO-3N1 GDSC2 5.6185 8.4753 2.3141 2.058
EW-7 GDSC2 5.7902 7.4615 2.78 0.2918
ES4 GDSC2 5.9675 8.2163 2.5746 0.7466
ES6 GDSC2 6.2049 8.0938 2.7111 0.2965
H-EMC-SS GDSC2 6.2652 8.6135 2.5476 0.6621
EW-16 GDSC2 6.3606 8.5213 2.6182 0.4391
EW-13 GDSC2 6.377 16.2223 -0.794 16.0076
EW-1 GDSC2 6.4171 8.4242 2.6735 0.3044
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1954 GDSC2 -4.5067 -1.5876 -4.514 76.164
BT-20 GDSC2 -3.8071 0.9277 -3.9592 67.1794
MDA-MB-330 GDSC2 -3.2758 1.715 -3.5119 62.7597
MRK-nu-1 GDSC2 -3.0185 -1.9148 -3.0185 63.6229
HCC1187 GDSC2 -2.9142 -1.5074 -2.9142 62.5612
OCUB-M GDSC2 -2.8654 -0.8564 -2.8675 61.9547
AU565 GDSC2 -2.8107 -1.4351 -2.8108 61.528
Evsa-T GDSC2 -2.0236 -1.071 -2.0236 53.6428
HCC2157 GDSC2 -0.862 4.6687 -1.6717 43.9531
MDA-MB-361 GDSC2 -0.3895 1.7528 -0.4319 37.4431
BT-474 GDSC2 0.0729 2.547 -0.0463 33.1897
MDA-MB-157 GDSC2 0.3739 4.1252 -0.1457 32.1092
CAMA-1 GDSC2 0.672 4.0199 0.2132 28.9417
MCF-7 GDSC2 0.8668 4.2833 0.3299 27.4389
HCC1428 GDSC2 0.9181 4.3852 0.3471 27.1146
HCC70 GDSC2 2.0368 7.3814 0.1421 23.531
HCC1500 GDSC2 2.1281 6.1512 0.8209 19.5334
MDA-MB-468 GDSC2 2.2241 4.683 1.5979 14.5886
HCC1569 GDSC2 2.9382 6.9565 1.1758 14.6494
DU4475 GDSC2 3.335 4.9582 2.5147 5.073
COLO 824 GDSC2 3.3852 9.1449 0.463 17.3505
EFM-192A GDSC2 3.3954 8.7278 0.68 16.1288
MDA-MB-415 GDSC2 3.4168 6.2277 1.9473 8.4267
HCC1937 GDSC2 3.4991 5.8494 2.2026 6.5877
JIMT-1 GDSC2 3.7086 5.9779 2.3008 5.424
CAL-51 GDSC2 3.9505 5.8302 2.545 3.3636
Hs 578T GDSC2 4.0994 8.9405 1.1313 11.5991
MDA-MB-453 GDSC2 4.1448 8.7833 1.243 10.8277
MFM-223 GDSC2 4.1636 8.5412 1.3762 9.9897
HDQ-P1 GDSC2 4.216 6.9637 2.1815 4.9955
BT-549 GDSC2 4.3061 6.6287 2.3991 3.5247
EFM-19 GDSC2 4.4231 10.535 0.5869 13.8492
HCC1419 GDSC2 4.5782 6.4844 2.6242 1.8378
CAL-120 GDSC2 5.0934 6.6189 2.8141 0.5231
HCC1143 GDSC2 5.5217 8.0707 2.4339 1.628
HCC38 GDSC2 5.5318 8.9231 2.0779 3.3121
HCC1806 GDSC2 5.6102 7.1623 2.8186 0.2725
T-47D GDSC2 5.6771 8.3294 2.4023 1.6094
CAL-85-1 GDSC2 5.8688 7.6148 2.7552 0.317
MDA-MB-436 GDSC2 5.9497 8.0168 2.6415 0.5609
MDA-MB-231 GDSC2 5.9771 8.3916 2.5123 0.9427
ZR-75-30 GDSC2 6.0498 7.6293 2.8156 0.1604
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PFSK-1 GDSC2 -1.7485 -0.1145 -1.7501 50.8799
8-MG-BA GDSC2 -1.1054 5.5384 -2.2549 46.233
GI-1 GDSC2 3.4996 11.9958 -0.8678 23.2964
DK-MG GDSC2 3.9637 5.7405 2.5966 3.0271
Daoy GDSC2 3.9911 5.747 2.6114 2.8845
U-251MG GDSC2 4.1106 6.6998 2.2365 4.8882
SW1088 GDSC2 4.5075 6.4285 2.61 2.0115
U-87MG ATCC GDSC2 4.657 12.7679 -0.3398 17.8847
A-172 GDSC2 4.9007 6.8194 2.6478 1.3308
LN-18 GDSC2 4.9096 6.0008 2.9676 0.1997
GB-1 GDSC2 4.9252 6.6257 2.7382 0.9216
D283 Med GDSC2 4.9423 12.1923 0.154 14.8352
YH-13 GDSC2 4.9698 6.8706 2.6602 1.2044
SF539 GDSC2 5.1345 10.8652 0.9331 10.3117
LN-405 GDSC2 5.1842 6.9571 2.7235 0.7679
D-263MG GDSC2 5.2163 6.8811 2.7663 0.5997
CAS-1 GDSC2 5.2192 6.4062 2.9395 0.1594
D-392MG GDSC2 5.3468 8.1374 2.3188 2.3551
Becker GDSC2 5.4029 7.0068 2.7951 0.4116
M059J GDSC2 5.4056 7.5423 2.5925 1.0825
GaMG GDSC2 5.503 7.0308 2.825 0.2966
T98G GDSC2 5.5603 7.2361 2.7733 0.3963
LN-229 GDSC2 5.7005 7.2989 2.804 0.2724
DBTRG-05MG GDSC2 5.707 7.867 2.598 0.8353
42-MG-BA GDSC2 5.7244 7.223 2.8392 0.1992
U-118MG GDSC2 5.7742 7.1988 2.8652 0.1465
SK-MG-1 GDSC2 5.8247 7.4597 2.7934 0.2542
H4 GDSC2 5.8733 7.5071 2.7946 0.2375
SF268 GDSC2 5.8776 7.889 2.6597 0.5467
KINGS-1 GDSC2 5.8819 8.0466 2.6031 0.7093
AM-38 GDSC2 6.0362 7.8778 2.7247 0.3236
KALS-1 GDSC2 6.2335 8.6678 2.5147 0.7751
KS-1 [Human Krukenberg tumour] GDSC2 6.3895 9.9916 2.064 2.3499
ONS-76 GDSC2 6.4438 8.0438 2.8122 0.0997
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 4.3442 6.7717 2.3564 3.7013
ETK-1 GDSC2 6.0063 8.0243 2.661 0.4828
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC2 1.4837 4.0114 1.0928 20.5646
EN GDSC2 2.6534 8.0911 0.3597 20.2205
KLE GDSC2 4.3957 6.8071 2.3722 3.5142
ESS-1 GDSC2 4.5173 6.6987 2.495 2.6134
MFE-296 GDSC2 4.5435 6.5437 2.5791 2.1209
AN3-CA GDSC2 4.8002 13.454 -0.5711 18.5645
MFE-319 GDSC2 5.2131 14.6671 -0.8622 18.813
MFE-280 GDSC2 6.1231 8.609 2.4911 0.9164
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MV4-11 GDSC2 -7.3351 -5.027 -7.3352 95.6039
MOLP-8 GDSC2 -6.0063 -4.8311 -6.0063 92.185
SU-DHL-6 GDSC2 -5.2617 -3.6527 -5.2617 85.1002
KMS-12-BM GDSC2 -5.0825 -2.8804 -5.0829 82.4181
SU-DHL-5 GDSC2 -4.7897 -3.6447 -4.7897 81.2539
A3/Kawakami GDSC2 -4.7319 -3.6964 -4.7319 80.7401
BC-1 GDSC2 -4.6523 -2.1758 -4.6542 78.2466
ML-2 GDSC2 -4.6089 -2.1595 -4.6107 77.9234
697 GDSC2 -4.5794 -3.3416 -4.5794 79.1475
AMO1 GDSC2 -4.5771 -3.3614 -4.5771 79.1364
KY821 GDSC2 -4.542 -3.3516 -4.542 78.8037
OPM-2 GDSC2 -4.4668 -3.2843 -4.4668 78.0668
DoHH2 GDSC2 -4.2759 -3.1815 -4.2759 76.202
BL-41 GDSC2 -4.1376 -3.3222 -4.1376 74.8527
P32/ISH GDSC2 -4.0516 -3.2466 -4.0516 73.9908
MOLM-13 GDSC2 -3.9946 -3.0166 -3.9946 73.4108
Raji GDSC2 -3.9797 -1.2967 -3.9859 71.9931
NCI-H929 GDSC2 -3.9671 -2.8549 -3.9671 73.1209
DEL GDSC2 -3.8027 -2.2339 -3.8028 71.3637
Kasumi-1 GDSC2 -3.7743 -0.8615 -3.7868 69.8276
JSC-1 GDSC2 -3.6638 -2.3254 -3.6638 70.0571
A4/Fukuda GDSC2 -3.5787 -2.1218 -3.5787 69.1836
RPMI-8226 GDSC2 -3.5349 -1.244 -3.5378 68.3057
Karpas-620 GDSC2 -3.3776 -2.2503 -3.3776 67.222
HL-60 GDSC2 -3.3055 -1.1313 -3.3079 66.1841
Ku812 GDSC2 -3.2441 0.3214 -3.2999 64.2823
EoL-1 GDSC2 -3.1272 -1.8946 -3.1272 64.7066
ST486 GDSC2 -2.9201 4.2675 -3.7701 58.0561
U-698-M GDSC2 -2.9124 -1.5784 -2.9125 62.5494
SU-DHL-10 GDSC2 -2.6429 -1.6663 -2.6429 59.8573
Namalwa GDSC2 -2.6358 -1.1792 -2.636 59.772
LP-1 GDSC2 -2.6305 -0.8914 -2.6314 59.6879
L-540 GDSC2 -2.5055 -1.3531 -2.5055 58.4766
L-363 GDSC2 -2.4583 -1.6754 -2.4583 58.0054
MOLT-13 GDSC2 -2.446 -0.4845 -2.4488 57.8151
GA-10 GDSC2 -2.4192 1.9446 -2.6284 56.4451
RS4;11 GDSC2 -2.4128 -0.329 -2.4173 57.4615
ALL-PO GDSC2 -2.3296 -0.1187 -2.3369 56.6126
KOPN-8 GDSC2 -2.1775 -0.3478 -2.1797 55.1594
DB GDSC2 -2.0355 0.6134 -2.0635 53.6419
Ramos.2G6.4C10 GDSC2 -1.8772 -0.8255 -1.8772 52.1734
MOLT-16 GDSC2 -1.8094 0.109 -1.8143 51.4832
SUP-M2 GDSC2 -1.7218 -0.0902 -1.7234 50.6126
Karpas-45 GDSC2 -1.5971 2.0284 -1.7566 49.4223
SR GDSC2 -1.5201 1.0294 -1.5554 48.6287
OCI-AML-2 GDSC2 -1.5006 0.384 -1.5068 48.404
HDLM-2 GDSC2 -1.4907 0.7895 -1.5106 48.3235
OCI-AML-3 GDSC2 -1.4257 -0.1659 -1.426 47.644
Karpas-422 GDSC2 -1.3995 1.7484 -1.502 47.5382
SK-MM-2 GDSC2 -1.3109 0.8388 -1.3279 46.5343
HH [Human lymphoma] GDSC2 -1.284 2.9101 -1.5985 46.7411
ME1 GDSC2 -1.2179 1.5466 -1.2843 45.7271
JJN-3 GDSC2 -1.1124 1.3023 -1.1506 44.6205
Karpas-1106P GDSC2 -1.0214 3.0086 -1.3363 44.3942
NOMO-1 GDSC2 -0.9026 3.3517 -1.2966 43.494
LC4-1 GDSC2 -0.8529 2.177 -0.9804 42.3427
ATN-1 GDSC2 -0.8352 1.9724 -0.9304 42.0683
WSU-NHL GDSC2 -0.8192 1.5057 -0.8606 41.7236
SCC-3 GDSC2 -0.5065 1.4463 -0.5301 38.5292
U266B1 GDSC2 -0.4124 3.8138 -0.8977 39.3204
MHH-CALL-2 GDSC2 -0.392 4.3768 -1.0614 39.6974
Reh GDSC2 -0.3225 2.113 -0.4023 36.9426
SUP-B15 GDSC2 -0.238 1.0825 -0.2412 35.74
P30/OHK GDSC2 0.0361 3.8307 -0.4148 35.0248
HAL-01 GDSC2 0.1687 1.6696 0.1553 31.7102
TUR GDSC2 0.1819 3.8391 -0.2589 33.5939
KG-1 GDSC2 0.6251 3.0239 0.4545 27.9385
SKM-1 GDSC2 0.9402 3.9004 0.5445 25.9832
Loucy GDSC2 0.963 4.1361 0.4869 26.1825
BV-173 GDSC2 1.166 4.2368 0.6684 24.3008
Jurkat GDSC2 1.3011 4.5168 0.705 23.5084
Karpas-231 GDSC2 1.3629 9.3275 -1.437 32.5645
KCL-22 GDSC2 1.4245 3.7741 1.1122 20.7158
Farage GDSC2 1.5566 9.0549 -1.122 30.7618
MLMA GDSC2 1.6596 5.6655 0.5843 22.6696
GDM-1 GDSC2 1.8325 6.3192 0.4538 22.6897
KE-37 GDSC2 1.8468 7.5984 -0.1428 25.6329
BALL-1 GDSC2 2.202 4.4336 1.6848 14.1584
L-1236 GDSC2 2.3987 5.7433 1.2763 15.8718
BE-13 GDSC2 2.4643 10.0856 -0.7988 26.2627
EM-2 GDSC2 2.5798 6.0015 1.3226 14.9533
MM1.S GDSC2 2.5958 4.52 2.0463 10.4693
CCRF-CEM GDSC2 2.6535 7.7671 0.5203 19.3561
WIL2 NS GDSC2 2.9509 5.4965 1.9118 10.0659
IM-9 GDSC2 3.0112 9.4286 0.006 20.8602
SUP-HD1 GDSC2 3.0906 6.5911 1.4908 12.2491
DG-75 GDSC2 3.2525 5.3371 2.2559 6.9534
KMOE-2 GDSC2 3.3151 9.0322 0.4611 17.5704
TK [Human B-cell lymphoma] GDSC2 3.3244 10.5511 -0.2906 21.3089
JVM-3 GDSC2 3.3611 8.2415 0.8947 15.0088
OCI-M1 GDSC2 3.5194 7.6581 1.3161 12.0515
VAL GDSC2 3.5256 10.142 0.0801 18.9264
HC-1 GDSC2 3.6145 6.0508 2.193 6.3402
CML-T1 GDSC2 3.6223 9.9154 0.272 17.6676
OCI-AML-5 GDSC2 3.7558 6.4234 2.1162 6.4592
CESS GDSC2 3.7644 5.8607 2.3998 4.6712
Daudi GDSC2 3.7852 5.4279 2.6256 3.2305
VL51 GDSC2 3.8538 13.2278 -1.195 23.5816
MOLT-4 GDSC2 3.9035 5.4117 2.7128 2.4571
EJM GDSC2 3.9308 7.4036 1.7636 8.2116
ALL-SIL GDSC2 3.9731 6.3657 2.3026 4.7877
RPMI-8866 GDSC2 3.9771 5.7525 2.5997 2.9822
Jiyoye GDSC2 3.9983 6.0126 2.49 3.5951
P12-Ichikawa GDSC2 4.0356 7.3752 1.8549 7.3948
JURL-MK1 GDSC2 4.1697 6.1703 2.527 3.036
EB2 GDSC2 4.1999 6.1221 2.5683 2.7417
NALM-6 GDSC2 4.3036 7.1691 2.1421 5.0486
CTV-1 GDSC2 4.3501 5.964 2.7274 1.6251
RC-K8 GDSC2 4.3522 5.9374 2.7402 1.556
PF-382 GDSC2 4.4424 6.6773 2.4606 2.9284
Hs 445 GDSC2 4.5154 6.3734 2.6385 1.8514
ARH-77 GDSC2 4.539 6.2278 2.7141 1.4398
MHH-PREB-1 GDSC2 4.539 6.3726 2.6517 1.7514
H9 GDSC2 4.5956 6.5929 2.5863 2.0083
KM-H2 GDSC2 4.6312 8.4618 1.7442 6.7353
L-428 GDSC2 4.6856 6.4708 2.6863 1.3953
MN-60 GDSC2 4.7521 7.0995 2.4498 2.4959
SUP-T1 GDSC2 4.791 7.0002 2.5147 2.1048
JVM-2 GDSC2 4.9216 7.5705 2.3361 2.8459
DND-41 GDSC2 5.128 7.0371 2.667 1.0277
SU-DHL-8 GDSC2 5.1548 6.6622 2.8231 0.4603
HEL GDSC2 5.2473 6.6329 2.8701 0.2919
CA46 GDSC2 5.3036 7.4287 2.5911 1.1766
K-562 GDSC2 5.3462 7.0672 2.75 0.5717
Granta-519 GDSC2 5.4737 7.2975 2.7161 0.6013
MEG-01 GDSC2 5.4791 8.8447 2.0835 3.3575
RPMI-6666 GDSC2 5.6335 7.192 2.8168 0.2684
LAMA-84 GDSC2 5.9419 7.609 2.7841 0.2372
GR-ST GDSC2 6.5971 8.8559 2.5883 0.4179
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC2 -0.352 5.0514 -1.264 40.0252
OS-RC-2 GDSC2 4.2253 6.1365 2.5773 2.6449
A-704 GDSC2 4.914 7.2865 2.4565 2.2334
VMRC-RCZ GDSC2 4.9679 7.311 2.4745 2.0718
LB996-RCC GDSC2 5.0295 6.9428 2.6591 1.1506
ACHN GDSC2 5.0622 7.2631 2.5432 1.6293
KTCTL-195 GDSC2 5.0855 6.8228 2.7325 0.8101
A-498 GDSC2 5.3327 6.8087 2.8397 0.3297
BFTC-909 GDSC2 5.361 6.9916 2.7841 0.4625
CAL-54 GDSC2 5.5382 7.7188 2.5822 1.014
RCC10RGB GDSC2 5.5414 7.1356 2.8022 0.3339
NCC010 GDSC2 5.6609 9.9046 1.715 5.0203
KMRC-20 GDSC2 5.7 7.5197 2.7248 0.4577
769-P GDSC2 6.0167 7.5536 2.8297 0.1474
RXF 393L GDSC2 6.075 8.4046 2.5482 0.7648
SN12C GDSC2 6.1678 7.7245 2.8245 0.1269
786-O GDSC2 6.1757 8.0685 2.7093 0.3091
HA7-RCC GDSC2 6.4477 8.0607 2.8079 0.1035
TK-10 GDSC2 6.5685 8.7783 2.6051 0.3923
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP5d GDSC2 -1.8534 -0.1991 -1.855 51.9297
COLO 320HSR GDSC2 -1.4839 2.2445 -1.6728 48.4058
CCK-81 GDSC2 0.0789 1.7787 0.0559 32.6592
SNU-175 GDSC2 1.2929 6.6738 -0.2444 28.3226
SNU-1040 GDSC2 1.8483 6.8326 0.2261 23.82
SNU-C1 GDSC2 3.4767 11.5288 -0.6533 22.4686
LoVo GDSC2 3.4839 5.371 2.4291 5.1994
C2BBe1 GDSC2 3.8331 5.6735 2.5401 3.647
HCC2998 GDSC2 3.8622 11.2255 -0.1891 19.2764
CW-2 GDSC2 3.9597 7.1347 1.9175 7.1917
COLO205 GDSC2 4.0389 6.7411 2.1667 5.4722
SW626 GDSC2 4.0974 6.1754 2.4781 3.4638
SNU-407 GDSC2 4.156 7.2455 2.0043 6.2006
DiFi GDSC2 4.168 6.5675 2.3385 4.1531
T84 GDSC2 4.2135 6.8125 2.2521 4.5767
HCT 15 GDSC2 4.2287 5.9 2.6872 2.0235
RKO GDSC2 4.3162 6.4164 2.5038 2.9027
NCI-H716 GDSC2 4.3679 10.0196 0.7998 12.8187
CaR-1 GDSC2 4.3959 9.9353 0.862 12.4017
SNU-61 GDSC2 4.6581 7.7632 2.0916 4.6494
SW948 GDSC2 4.7329 11.3665 0.4063 14.0486
SNU-81 GDSC2 4.7454 6.5039 2.7023 1.2532
LS180 GDSC2 4.753 6.7883 2.586 1.7974
MDST8 GDSC2 4.992 6.3564 2.8708 0.4094
HT-29 GDSC2 5.0065 6.1163 2.9629 0.1774
HT-55 GDSC2 5.1152 6.6583 2.8083 0.5282
HT115 GDSC2 5.1324 6.6225 2.8288 0.4558
SW48 GDSC2 5.1646 7.1011 2.6582 1.0306
RCM-1 [Human ESC] GDSC2 5.2113 6.6431 2.8525 0.3505
SW1116 GDSC2 5.247 6.7314 2.8344 0.3815
SW1463 GDSC2 5.2519 6.8826 2.7804 0.5334
HCT 116 GDSC2 5.2833 6.824 2.8148 0.4165
LS411N GDSC2 5.3832 7.0661 2.7655 0.5043
LS123 GDSC2 5.3907 7.2531 2.6983 0.7103
LS1034 GDSC2 5.5061 7.2485 2.7474 0.4911
SNU-C5 GDSC2 5.5553 7.4783 2.6818 0.6592
SW1417 GDSC2 5.6247 7.3112 2.771 0.3742
KM12 GDSC2 5.707 7.0626 2.8879 0.1283
COLO 678 GDSC2 5.7917 7.9807 2.5905 0.8047
SW620 GDSC2 5.855 7.4103 2.8215 0.1956
CL-11 GDSC2 5.8856 7.7791 2.7029 0.4306
LS513 GDSC2 5.9746 7.3959 2.8682 0.1066
SK-CO-1 GDSC2 5.9776 7.694 2.7675 0.2575
NCI-H747 GDSC2 6.1678 8.2068 2.6574 0.4238
SW837 GDSC2 6.2777 8.224 2.6923 0.3105
SNU-C2B GDSC2 6.7904 9.0275 2.5995 0.3332
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.7921 7.4548 2.783 0.2849
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 -3.0103 2.2163 -3.3212 60.4646
JHH-1 GDSC2 1.8891 5.7998 0.7522 20.8317
Hep 3B2.1-7 GDSC2 3.3066 4.4808 2.7297 3.7948
HLE GDSC2 3.7834 6.0394 2.3259 5.0842
JHH-6 GDSC2 3.9083 8.3584 1.2741 11.2474
SNU-387 GDSC2 4.132 9.0351 1.1092 11.6455
SNU-423 GDSC2 4.4598 9.17 1.2834 9.8302
JHH-4 GDSC2 5.0307 7.0196 2.6284 1.2806
Hep-G2/C3A GDSC2 5.219 6.5892 2.875 0.2918
SK-HEP-1 GDSC2 5.2218 6.6001 2.8721 0.2974
HuH-1 GDSC2 5.2582 6.579 2.8934 0.2362
Huh-7 GDSC2 5.6283 7.2344 2.7998 0.3063
JHH-2 GDSC2 5.7335 7.6102 2.7049 0.4946
SNU-449 GDSC2 5.7938 7.541 2.7532 0.3487
JHH-7 GDSC2 5.8741 7.235 2.8876 0.1001
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-427 GDSC2 -3.2264 -0.1309 -3.2531 64.6496
NCI-H1581 GDSC2 -1.9478 -0.7276 -1.9479 52.8815
NCI-H82 GDSC2 -1.7297 0.8125 -1.7587 50.6748
NCI-H1623 GDSC2 -1.0237 3.2401 -1.3985 44.533
DMS 273 GDSC2 -1.0074 0.9882 -1.0228 43.5044
NCI-H23 GDSC2 -0.6516 3.121 -0.9613 40.9811
NCI-H1876 GDSC2 0.4044 7.4504 -1.4898 36.7765
IST-SL2 GDSC2 0.5239 4.4565 -0.1023 31.1691
NCI-H522 GDSC2 0.8592 4.4464 0.2611 27.8232
NCI-H2122 GDSC2 1.1838 9.5437 -1.7112 34.0885
SHP-77 GDSC2 2.0164 4.6397 1.4041 16.5545
EPLC-272H GDSC2 2.1254 9.4169 -0.7723 27.3343
NCI-H2795 GDSC2 2.5109 6.6307 0.951 17.4065
NCI-H1092 GDSC2 2.7025 6.3351 1.2725 14.8387
HARA [Human squamous cell lung carcinoma] GDSC2 2.8241 6.5389 1.2818 14.3784
Ms-1 GDSC2 2.8701 5.55 1.812 10.9552
NCI-H1963 GDSC2 2.923 5.2494 2.0084 9.5528
EMC-BAC-2 GDSC2 3.0828 8.5434 0.5093 18.0224
UMC-11 GDSC2 3.2602 5.0414 2.4102 5.9543
NCI-H211 GDSC2 3.3266 7.2883 1.3426 12.4468
SBC-5 GDSC2 3.3424 5.9839 2.008 8.257
NCI-H524 GDSC2 3.4481 8.6237 0.7754 15.4364
NCI-H2029 GDSC2 3.4921 6.7702 1.7375 9.5314
NCI-H661 GDSC2 3.7353 7.8483 1.3933 10.9875
Lu-139 GDSC2 3.782 5.5392 2.5694 3.5818
NCI-H841 GDSC2 3.7844 5.9294 2.3807 4.7419
EKVX GDSC2 3.8552 6.2419 2.279 5.2045
NCI-H1694 GDSC2 3.8937 8.6701 1.1081 12.2694
NCI-H1155 GDSC2 3.9228 14.3575 -1.7035 25.2227
NCI-H2227 GDSC2 3.9469 6.747 2.0982 6.1059
NCI-H1651 GDSC2 3.9641 8.4768 1.2582 11.1971
NCI-H596 GDSC2 4.007 6.2672 2.3737 4.2794
NCI-H2731 GDSC2 4.0179 6.2576 2.3858 4.183
NCI-H1563 GDSC2 4.0301 7.2013 1.9361 6.9087
KNS-62 GDSC2 4.0519 6.0374 2.5138 3.3429
NCI-H2023 GDSC2 4.0593 6.0012 2.5357 3.1978
DMS 114 GDSC2 4.0678 12.1808 -0.5023 20.1467
NCI-H2141 GDSC2 4.1026 5.9548 2.5853 2.8224
SBC-3 GDSC2 4.1262 6.689 2.2523 4.7589
NCI-H209 GDSC2 4.1461 8.2739 1.4947 9.3217
LCLC-103H GDSC2 4.1466 5.5534 2.7954 1.5652
NCI-H1048 GDSC2 4.1604 6.4425 2.3929 3.8439
NCI-H345 GDSC2 4.1696 5.1454 2.9824 0.6161
NCI-H526 GDSC2 4.1807 8.8471 1.2383 10.7665
NCI-H1650 GDSC2 4.2375 6.3125 2.5034 3.0471
HCC44 GDSC2 4.2564 6.3329 2.5056 2.9997
NCI-H2818 GDSC2 4.3189 6.5316 2.4523 3.1928
IA-LM GDSC2 4.3744 6.2346 2.621 2.1532
SW1573 GDSC2 4.4363 6.7579 2.4199 3.1686
NCI-H2595 GDSC2 4.5539 8.0243 1.9012 5.9677
HCC78 GDSC2 4.5633 6.6228 2.5552 2.2182
HCC15 GDSC2 4.5711 7.0362 2.3737 3.1968
NCI-H1869 GDSC2 4.6538 8.2014 1.8829 5.8737
NCI-H2135 GDSC2 4.7201 6.2113 2.8096 0.8169
RERF-LC-Sq1 GDSC2 4.7207 13.3441 -0.5765 18.784
DMS 79 GDSC2 4.7276 6.6596 2.6278 1.6247
NCI-H1993 GDSC2 4.7348 8.4538 1.8163 6.1021
NCI-H1666 GDSC2 4.7801 6.9106 2.5476 1.9531
COR-L311 GDSC2 4.8144 13.008 -0.3405 17.5004
NCI-H1568 GDSC2 4.8247 7.5929 2.2707 3.3482
NCI-H3122 GDSC2 4.8422 7.1796 2.4642 2.292
HCC366 GDSC2 4.844 7.3622 2.3849 2.7029
NCI-H513 GDSC2 4.8624 6.8509 2.6157 1.5206
NCI-H1299 GDSC2 4.9402 7.6997 2.2892 3.0674
NCI-H810 GDSC2 4.9447 11.4559 0.5152 12.9812
NCI-H1793 GDSC2 5.0564 6.907 2.686 1.0147
NCI-H3255 GDSC2 5.0645 7.2229 2.561 1.5448
NCI-H720 GDSC2 5.1011 6.4716 2.8718 0.3512
RERF-LC-KJ GDSC2 5.105 7.2294 2.5782 1.4246
LXF 289 GDSC2 5.1512 8.0973 2.2313 3.0604
CPC-N GDSC2 5.1736 7.0386 2.687 0.9108
NCI-H1781 GDSC2 5.1863 6.9898 2.7117 0.8087
Calu-3 GDSC2 5.2068 6.9289 2.7441 0.6798
NCI-H196 GDSC2 5.228 7.1416 2.6708 0.9284
NCI-H2722 GDSC2 5.2386 6.9738 2.7404 0.6707
NCI-H226 GDSC2 5.244 6.7348 2.832 0.3893
LK-2 GDSC2 5.2536 6.9303 2.7632 0.5862
SK-LU-1 GDSC2 5.2543 6.9759 2.7463 0.6407
NCI-H1975 GDSC2 5.2811 7.2816 2.6394 1.0051
NCI-H2369 GDSC2 5.2876 6.7994 2.8255 0.3857
Calu-6 GDSC2 5.3419 7.4082 2.6168 1.0416
NCI-H727 GDSC2 5.3631 7.4617 2.6051 1.0691
NCI-H2228 GDSC2 5.3904 7.5661 2.5761 1.1599
SW1271 GDSC2 5.4485 7.51 2.6242 0.9286
COR-L23 GDSC2 5.4599 6.8838 2.8609 0.2358
NCI-H1355 GDSC2 5.5026 7.6119 2.6082 0.9457
NCI-H358 GDSC2 5.533 8.199 2.3866 1.8242
NCI-H1435 GDSC2 5.5361 6.9956 2.8498 0.2336
DMS 53 GDSC2 5.544 7.7146 2.5864 0.9941
NCI-H250 GDSC2 5.5489 7.1392 2.8037 0.3274
NCI-H650 GDSC2 5.57 7.3351 2.741 0.4766
Lu-165 GDSC2 5.5738 7.1116 2.8229 0.2758
Lu-65 GDSC2 5.5927 7.3799 2.7336 0.4857
Lu-135 GDSC2 5.6103 7.3635 2.7465 0.4426
NCI-H446 GDSC2 5.6309 15.6047 -1.0177 18.495
NCI-H2810 GDSC2 5.6365 8.007 2.5128 1.1981
HOP-62 GDSC2 5.744 7.7024 2.6752 0.5721
NCI-H441 GDSC2 5.7626 7.5886 2.7242 0.4309
NCI-H2087 GDSC2 5.7821 7.7689 2.6659 0.5784
HCC827 GDSC2 5.7831 7.2536 2.8496 0.1677
NCI-H2461 GDSC2 5.7918 7.5805 2.7383 0.384
Lu-99A GDSC2 5.7933 7.8591 2.6369 0.6576
LCLC-97TM1 GDSC2 5.7961 8.0044 2.5833 0.8254
NCI-H2803 GDSC2 5.8139 7.5086 2.7722 0.3001
VMRC-LCD GDSC2 5.8278 7.3423 2.8351 0.1801
COLO 668 GDSC2 5.8289 7.6746 2.7187 0.4158
NCI-H1944 GDSC2 5.8291 7.7707 2.6839 0.5049
A-549 GDSC2 5.9272 7.9181 2.6687 0.4988
NCI-H2373 GDSC2 5.9301 7.6647 2.7604 0.2859
LOU-NH91 GDSC2 5.932 7.5848 2.7889 0.2313
NCI-H2804 GDSC2 5.9437 8.3754 2.5042 0.9934
NCI-H1693 GDSC2 5.9574 7.7375 2.7449 0.3084
EBC-1 GDSC2 5.9665 8.1801 2.5878 0.7071
ABC-1 GDSC2 5.9994 8.0312 2.6558 0.4991
NCI-H2085 GDSC2 6.0481 8.0713 2.6602 0.4665
NCI-H2869 GDSC2 6.0599 7.9186 2.7191 0.3271
PC-14 GDSC2 6.0714 7.7662 2.7764 0.2161
NCI-H520 GDSC2 6.0873 7.6162 2.8331 0.13
NCI-H1915 GDSC2 6.0899 7.756 2.7866 0.1951
NCI-H1755 GDSC2 6.1315 7.9757 2.7255 0.2913
NCI-H2591 GDSC2 6.2456 8.5332 2.5693 0.6119
LC-1/sq GDSC2 6.2555 8.2133 2.6879 0.3263
NCI-H2170 GDSC2 6.3011 8.0572 2.7584 0.1906
COR-L105 GDSC2 6.372 9.0985 2.4098 1.0224
NCI-H1792 GDSC2 6.3809 8.4823 2.6397 0.3841
NCI-H2405 GDSC2 6.3939 8.4326 2.662 0.3336
HOP-92 GDSC2 6.4174 8.4126 2.6776 0.2966
SK-MES-1 GDSC2 6.5431 8.2529 2.7764 0.1234
NCI-H322M GDSC2 6.724 8.5486 2.7395 0.1374
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.7003 6.9161 2.5019 2.298
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-180 GDSC2 1.5491 3.8175 1.2323 19.4982
TE-4 GDSC2 2.4827 4.4586 1.9609 11.4145
KYSE-270 GDSC2 3.8128 7.12 1.8149 8.192
TE-8 GDSC2 4.2022 9.4359 0.964 12.3068
TE-6 GDSC2 4.2065 6.4165 2.4351 3.5037
KYSE-140 GDSC2 4.2104 7.3902 1.9722 6.2744
EC-GI-10 GDSC2 4.3451 12.8284 -0.6078 19.8739
TE-15 GDSC2 4.4343 8.3368 1.6701 7.598
COLO 680N GDSC2 4.7347 6.8012 2.5707 1.8973
OE21 GDSC2 4.8404 12.5545 -0.0981 16.3061
OE19 GDSC2 5.0444 6.7081 2.7591 0.7436
TE-5 GDSC2 5.2333 7.1103 2.6854 0.8695
KYSE-450 GDSC2 5.3167 6.8115 2.8325 0.3544
OE33 GDSC2 5.5663 7.6417 2.6243 0.842
TE-1 GDSC2 5.5858 13.7247 -0.1349 14.7712
KYSE-70 GDSC2 5.6937 7.4337 2.7534 0.388
KYSE-410 GDSC2 5.7499 7.7645 2.6545 0.6293
KYSE-520 GDSC2 5.9931 8.4592 2.4932 0.997
TE-9 GDSC2 6.412 19.2617 -2.2426 21.2185
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVK18 GDSC2 -0.1836 6.1764 -1.5364 39.7898
A2780 GDSC2 1.9474 5.8015 0.8091 20.2851
OV56 GDSC2 3.3666 4.5647 2.7373 3.5736
TOV-112D GDSC2 3.5093 7.7518 1.2611 12.4128
OAW42 GDSC2 4.0514 5.5228 2.7536 1.9491
OV-90 GDSC2 4.0959 5.9187 2.5979 2.762
IGROV-1 GDSC2 4.6982 8.3213 1.8551 5.9483
OVISE GDSC2 4.8225 6.265 2.8343 0.6381
ES-2 GDSC2 5.1102 6.4951 2.8669 0.3601
EFO-27 GDSC2 5.1797 7.4382 2.5284 1.5672
EFO-21 GDSC2 5.1918 6.8942 2.751 0.6665
TOV-21G GDSC2 5.2966 6.6568 2.8802 0.2507
OVCAR-5 GDSC2 5.464 7.1403 2.7705 0.4485
OVCAR-3 GDSC2 5.5497 7.2768 2.7543 0.4505
SK-OV-3 GDSC2 5.5813 7.1112 2.8258 0.2672
Kuramochi GDSC2 5.6584 7.8005 2.6028 0.8524
DOV13 GDSC2 5.7173 7.3064 2.8076 0.2598
OAW28 GDSC2 5.741 8.1072 2.52 1.0865
TYK-nu GDSC2 5.8144 7.9307 2.6188 0.7007
OVCAR-4 GDSC2 5.968 7.8468 2.7101 0.3802
OVCAR-8 GDSC2 6.2502 7.8713 2.8036 0.1386
OVTOKO GDSC2 6.7439 8.5828 2.7348 0.1396
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BxPC-3 GDSC2 3.8741 5.8374 2.4893 3.8662
PSN1 GDSC2 4.0812 13.2246 -1.0117 22.2508
HuP-T4 GDSC2 4.1473 7.6358 1.8081 7.417
QGP-1 GDSC2 4.1774 9.9714 0.6804 13.9631
HuP-T3 GDSC2 4.3203 7.6319 1.9316 6.2783
MIA PaCa-2 GDSC2 4.5561 6.1415 2.7593 1.2034
HPAC GDSC2 4.7607 6.6831 2.6349 1.5501
PaTu 8988t GDSC2 4.9145 6.4875 2.788 0.7376
Panc 08.13 GDSC2 4.9164 7.3409 2.4341 2.3436
PaTu 8902 GDSC2 5.0178 6.1919 2.9405 0.2199
SU.86.86 GDSC2 5.0738 6.6794 2.7829 0.6384
YAPC GDSC2 5.086 6.4428 2.8764 0.3462
SUIT-2 GDSC2 5.2262 6.7402 2.8229 0.423
Capan-2 GDSC2 5.3403 7.4575 2.5964 1.1227
KP-4 GDSC2 5.3535 6.9125 2.8101 0.3953
Panc 02.03 GDSC2 5.3734 6.8364 2.8453 0.3
KP-2 GDSC2 5.4377 6.7185 2.9102 0.1532
DAN-G GDSC2 5.481 6.9782 2.8354 0.2817
KP-1N GDSC2 5.583 7.9185 2.5236 1.2008
CFPAC-1 GDSC2 5.6019 7.2741 2.7756 0.3726
PL4 GDSC2 5.6503 7.8724 2.5716 0.9675
Capan-1 GDSC2 5.7097 7.3394 2.7931 0.2919
HPAF-II GDSC2 5.9962 7.8117 2.7331 0.3195
Panc 10.05 GDSC2 6.1224 7.9787 2.7211 0.3026
KP-3 GDSC2 6.2362 8.4482 2.5966 0.5439
AsPC-1 GDSC2 6.2685 8.2137 2.6926 0.3129
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 4.2011 6.4963 2.394 3.7562
MPP 89 GDSC2 4.264 7.6339 1.8917 6.6432
NCI-H2052 GDSC2 5.1592 7.2056 2.6137 1.217
IST-Mes1 GDSC2 5.4494 8.1236 2.3767 1.9598
NCI-H28 GDSC2 6.2231 7.8838 2.79 0.1615
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2 -1.3953 0.1339 -1.3968 47.3417
DU145 GDSC2 4.1811 6.4968 2.3808 3.8747
22Rv1 GDSC2 4.6251 7.5846 2.154 4.3505
PC-3 GDSC2 6.1177 8.3946 2.5694 0.6776
LNCaP clone FGC GDSC2 6.144 8.3913 2.5811 0.6304
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.1473 7.5461 1.852 7.1496
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UACC-62 GDSC2 -1.9922 1.0366 -2.0494 53.1519
HT-144 GDSC2 -1.2822 1.6733 -1.3673 46.3881
SK-MEL-2 GDSC2 -0.0913 3.5386 -0.4644 35.9181
WM1552C GDSC2 0.1108 3.328 -0.1842 33.6334
COLO 792 GDSC2 0.828 5.7297 -0.2944 30.5871
A2058 GDSC2 3.4154 7.668 1.2263 12.8919
IGR-37 GDSC2 3.7087 5.4317 2.5694 3.7508
CHL-1 GDSC2 3.8433 7.9552 1.4242 10.5137
WM115 GDSC2 3.8449 6.7566 2.0186 6.846
G-mel GDSC2 3.8463 9.2099 0.8027 14.1589
G-361 GDSC2 3.9021 7.0497 1.9167 7.3371
M14 GDSC2 4.4499 8.6751 1.5172 8.4741
A-375 GDSC2 4.5193 6.6972 2.4968 2.6005
RPMI-7951 GDSC2 4.596 6.6058 2.5808 2.0363
Mel JuSo GDSC2 4.6044 6.2303 2.7464 1.2083
HMV-II GDSC2 4.6053 8.7469 1.5901 7.6992
WT2-iPS GDSC2 4.7496 6.0853 2.8722 0.5564
CP66-MEL GDSC2 4.7699 6.3879 2.7617 0.9681
IGR-1 GDSC2 4.7766 6.2875 2.8051 0.7855
GAK GDSC2 5.0251 6.3093 2.9012 0.3099
COLO 829 GDSC2 5.0711 7.4137 2.4843 1.8956
LOX-IMVI GDSC2 5.143 6.799 2.7666 0.6466
SK-MEL-5 GDSC2 5.1535 6.7828 2.7772 0.6042
SK-MEL-24 GDSC2 5.2991 6.9106 2.7892 0.4807
WM278 GDSC2 5.3797 7.2113 2.7096 0.6801
COLO 679 GDSC2 5.3963 6.9341 2.819 0.3535
UACC-257 GDSC2 5.4854 7.097 2.7946 0.3756
WM793 GDSC2 5.5009 6.8831 2.8761 0.1946
SH-4 GDSC2 5.6291 7.9691 2.5244 1.1591
A101D GDSC2 6.6116 16.2584 -0.6528 14.9538
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 1.7839 10.5458 -1.6401 31.629
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC2 -0.6907 1.8134 -0.7562 40.5386
Rh30 GDSC2 3.5096 8.5428 0.8662 14.7398
EW-8 GDSC2 3.6781 6.0917 2.2215 5.9969
MES-SA GDSC2 4.0346 6.9681 2.0532 6.178
RKN GDSC2 4.1435 5.637 2.7562 1.7823
A-204 GDSC2 4.252 6.8174 2.2753 4.3594
G-402 GDSC2 4.3387 12.7877 -0.5926 19.8242
HT-1080 GDSC2 4.4265 7.2011 2.2075 4.4148
SW684 GDSC2 4.6947 6.1513 2.8219 0.7901
GCT GDSC2 4.732 8.4099 1.8352 5.9971
SW982 GDSC2 4.9294 6.3341 2.8535 0.4991
VA-ES-BJ GDSC2 5.0925 6.4837 2.8641 0.3763
SK-UT-1 GDSC2 5.1231 8.4715 2.0482 4.0838
SW872 GDSC2 5.5211 7.3273 2.7243 0.5495
G-401 GDSC2 5.5309 9.4291 1.8536 4.486
KYM-1 GDSC2 5.6988 7.079 2.8794 0.1417
SK-LMS-1 GDSC2 6.1085 7.9162 2.7379 0.2746
RD GDSC2 6.3718 8.3596 2.6794 0.3066
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC11TKB GDSC2 -0.9345 5.4021 -2.0203 44.9265
SNU-1 GDSC2 1.4371 5.8071 0.2956 25.1119
HGC-27 GDSC2 1.4654 5.2163 0.5858 23.4589
RERF-GC-1B GDSC2 1.9941 7.1782 0.1999 23.3981
ECC10 GDSC2 2.6203 6.4861 1.1228 16.0165
ECC12 GDSC2 2.6986 11.7241 -1.4093 27.7817
23132/87 GDSC2 4.0022 8.729 1.1623 11.6666
SNU-5 GDSC2 4.1084 5.6584 2.7258 2.0081
IM95 GDSC2 4.2167 8.6346 1.3694 9.9008
MKN1 GDSC2 4.261 6.4673 2.446 3.3362
RF-48 GDSC2 4.3518 6.386 2.5393 2.6407
MKN28 GDSC2 4.4934 6.5889 2.5306 2.4578
KATO III GDSC2 4.8609 6.633 2.7052 1.1195
MKN45 GDSC2 4.9197 6.0968 2.9372 0.2658
NUGC-3 GDSC2 5.0719 6.6863 2.7794 0.6516
AGS GDSC2 5.1283 9.8641 1.406 7.683
GCIY GDSC2 5.4972 7.0143 2.8287 0.2906
SK-GT-2 GDSC2 5.6207 8.0303 2.4964 1.2758
NCI-N87 GDSC2 5.6718 7.9742 2.5414 1.0611
OCUM-1 GDSC2 5.6769 7.6883 2.6531 0.6757
Hs 746.T GDSC2 5.8391 7.3712 2.8292 0.1868
NUGC-4 GDSC2 5.9446 7.6574 2.7682 0.266
SNG-M GDSC2 4.5802 6.553 2.5953 1.9833
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC2 3.9819 6.3353 2.3235 4.6403
FTC-133 GDSC2 4.0338 5.8535 2.5889 2.9339
IHH-4 GDSC2 4.1363 5.9359 2.6152 2.5876
K5 GDSC2 4.3972 6.58 2.4779 2.9084
B-CPAP GDSC2 4.9863 6.32 2.882 0.3804
WRO GDSC2 5.1758 6.9343 2.7287 0.7554
8505C GDSC2 5.2091 7.166 2.6526 1.0142
ASH-3 GDSC2 5.2846 6.7184 2.8537 0.3157
CAL-62 GDSC2 5.5111 7.147 2.7864 0.3848
BHT-101 GDSC2 5.6491 7.2975 2.7852 0.3311
TT2609-C02 GDSC2 5.8467 7.6574 2.7317 0.3776
8305C GDSC2 6.0391 7.6876 2.7919 0.1987
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 GDSC2 -0.8795 2.2195 -1.0161 42.6277
CAL-27 GDSC2 0.5538 8.2483 -1.7073 36.6888
UPCI-SCC-090 GDSC2 0.9111 8.5389 -1.493 34.5583
FaDu GDSC2 1.1142 4.0403 0.6842 24.4464
LB771-HNC GDSC2 2.5362 6.318 1.1275 16.2775
BICR 22 GDSC2 2.5865 8.9652 -0.1338 22.9287
Detroit 562 GDSC2 3.4638 8.0413 1.0794 13.6285
SCC-9 GDSC2 3.719 9.5869 0.5139 16.11
HSC-3 GDSC2 3.9435 8.2085 1.3753 10.5486
PCI-04B GDSC2 4.0227 8.2334 1.423 10.0598
HO-1-N-1 GDSC2 4.0533 10.4001 0.3724 15.9483
CAL-33 GDSC2 4.3467 6.6101 2.4332 3.2524
SCC-4 GDSC2 4.4201 8.9422 1.3661 9.4365
SAT [Human HNSCC] GDSC2 4.6286 10.3151 0.8455 11.9329
SAS GDSC2 4.9043 14.4621 -0.9907 20.069
SKN-3 GDSC2 5.4474 7.9631 2.4422 1.6677
JHU-022 GDSC2 5.4778 8.1343 2.3863 1.8845
BICR 78 GDSC2 5.6189 7.4177 2.7301 0.4823
Ca9-22 GDSC2 5.6566 7.567 2.6901 0.5756
SCC-15 GDSC2 5.6845 7.6911 2.6552 0.6648
HSC-4 GDSC2 5.765 6.9463 2.9464 0.057
DOK GDSC2 5.887 18.5104 -2.2551 22.3481
NCI-H3118 GDSC2 5.9244 8.1191 2.5934 0.7142
BICR 10 GDSC2 5.9738 7.6021 2.798 0.2048
OSC-20 GDSC2 6.1239 7.911 2.7453 0.2563
BB49-HNC GDSC2 6.2615 8.2276 2.6851 0.33
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC2 3.7893 11.1191 -0.1944 19.5052
RT-4 GDSC2 3.9081 5.9225 2.4718 3.8982
TCCSUP GDSC2 4.0224 6.1243 2.4528 3.7684
CAL-29 GDSC2 4.3194 5.9593 2.7125 1.7475
BFTC-905 GDSC2 4.4501 6.0528 2.7426 1.413
SW780 GDSC2 4.5292 7.1135 2.3128 3.6138
639V GDSC2 4.7796 6.0291 2.9063 0.4236
SW1710 GDSC2 4.953 8.0403 2.1435 3.8385
KU-19-19 GDSC2 5.032 6.6003 2.7954 0.6244
HT-1197 GDSC2 5.2246 6.5369 2.8957 0.2428
647V GDSC2 5.5424 6.86 2.8989 0.1465
HT-1376 GDSC2 5.8664 8.0603 2.5915 0.7545
J82 GDSC2 6.0895 7.9197 2.7297 0.296
5637 GDSC2 6.1541 8.0256 2.7164 0.302
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DSH1 GDSC2 -3.2147 8.5691 -5.7056 56.7266
PA-1 GDSC2 -2.1304 3.2756 -2.6158 53.611
MS751 GDSC2 -1.3243 2.1301 -1.48 46.8995
NEC8 GDSC2 -0.854 2.2482 -0.9935 42.39
CAL-39 GDSC2 0.4753 3.0085 0.295 29.4823
HeLa GDSC2 3.1544 7.771 0.9563 15.2743
SiHa GDSC2 3.4191 4.7745 2.6749 3.8228
ME-180 GDSC2 3.4874 5.6855 2.275 6.1626
C-4-I GDSC2 3.9249 5.9019 2.4933 3.7304
PWR-1E GDSC2 4.2745 6.3088 2.5279 2.8393
PEO1 GDSC2 4.2765 7.6735 1.8811 6.6793
DoTc2 4510 GDSC2 4.3247 7.6368 1.9322 6.2649
LB831-BLC GDSC2 4.3487 6.3761 2.5419 2.6314
HT-3 GDSC2 4.5494 8.9211 1.4676 8.5438
HEC-1 GDSC2 4.8159 6.3822 2.7853 0.8296
SW756 GDSC2 4.9341 6.4002 2.8303 0.5725
TC-YIK GDSC2 5.0157 6.9381 2.6545 1.1836
BPH-1 GDSC2 5.1124 9.6592 1.4923 7.2253
OVMIU GDSC2 5.1521 8.7322 1.9471 4.5922
SKG-IIIa GDSC2 5.1725 6.793 2.7813 0.5788
SKN GDSC2 5.3211 7.4406 2.5944 1.1476
C-33 A GDSC2 5.3552 7.7613 2.4805 1.5948
SiSo GDSC2 6.2589 8.2449 2.678 0.3453
HEY GDSC2 6.2623 8.2351 2.6828 0.3344
Ca Ski GDSC2 6.9455 9.261 2.5747 0.3343
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies. Clin Cancer Res. 2023 Jan 17;29(2):446-457. doi: 10.1158/1078-0432.CCR-22-2088.