Details of the Drug

General Information of Drug (ID: DM7U8ID)

Drug Name
6,7-Diphenyl-pteridine-2,4-diamine
Synonyms
6,7-diphenylpteridine-2,4-diamine; 18181-93-6; 2,4-DIAMINO-6,7-DIPHENYL-PTERIDINE; NSC10922; CHEMBL48296; 2,4-Diamino-6,7-diphenylpteridine; AC1Q4WHR; AC1L5CHW; diphenylpteridine-2,4-diamine; SCHEMBL3746280; diaminopteridine derivative, 24; CTK4D7985; BDBM25101; DTXSID80278987; DDZJPETYMUJLIW-UHFFFAOYSA-N; ZINC1712532; NSC-10922; 2,4-Pteridinediamine,6,7-diphenyl-; 6,7-Diphenyl-2,4-pteridinediamine #; 2,4-Pteridinediamine, 6,7-diphenyl-; ACM18181936; DB-081833
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 314.3
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H14N6
IUPAC Name
6,7-diphenylpteridine-2,4-diamine
Canonical SMILES
C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2C4=CC=CC=C4)N)N
InChI
InChI=1S/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)
InChIKey
DDZJPETYMUJLIW-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
223355
CAS Number
18181-93-6
TTD ID
D01ILN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Polypeptide deformylase (PDF) TT9SL3Q DEFM_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Polypeptide deformylase (PDF) DTT PDF 8.87E-16 -0.54 -0.86
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36.