General Information of Drug (ID: DM86LFB)

Drug Name
Thiorphan
Synonyms
(S)-THIORPHAN; (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE; CHEMBL298827; 95909-00-5; 1zdp; AC1N9ZZO; Lopac-T-6031; SCHEMBL49662; GTPL5278; Glycine, N-[(2S)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-; ZINC3872336; BDBM50024102; DB08626; NCGC00016033-01; NCGC00016933-01; CAS-76721-89-6; N-[(2S)-2-benzyl-3-sulfanylpropanoyl]glycine; 2-[(2S)-2-benzyl-3-sulfanylpropanamido]acetic acid; (S) (2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acid; 2-[[(2S)-2-benzyl-3-sulfanylpropanoyl]amino]acetic acid; UNII-B79L7B5X3Z component LJJ
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 253.32
Logarithm of the Partition Coefficient (xlogp) 1.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 11.1177 micromolar/kg/day [2]
Chemical Identifiers
Formula
C12H15NO3S
IUPAC Name
2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid
Canonical SMILES
C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
InChI
InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
InChIKey
LJJKNPQAGWVLDQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3132
ChEBI ID
CHEBI:9568
CAS Number
76721-89-6
UNII
XJ8Z52GK3X
DrugBank ID
DB08626
TTD ID
D0PB5Q

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neutral endopeptidase (MME) TT5TKPM NEP_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [4]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [4]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Gene/Protein Processing [5]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [5]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Post-Translational Modifications [4]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5278).
2 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
3 Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery. J Pharm Pharmacol. 2003 Mar;55(3):339-45.
4 Neutral endopeptidase (NEP) inhibitors - thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro. Chem Biol Interact. 2019 Jul 1;307:105-115. doi: 10.1016/j.cbi.2019.04.033. Epub 2019 May 1.
5 Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis. J Neurochem. 2006 Feb;96(3):777-89.