Details of the Drug

General Information of Drug (ID: DM8AM60)

• Drug Name: TC-5214
• Synonyms: Dexmecamylamine; DEXMECAMYLAMINE; UNII-5Y1141YI4U; 107538-05-6; 5Y1141YI4U; TC 5214; (1R,2S,4S)-N,2,3,3-Tetramethylbicyclo(2.2.1)heptan-2-amine; Dexmecamylamine [USAN:INN]; Dexmecamylamine (USAN); CHEMBL2103881; BDBM50045047; ZINC43763856; DB11807; D10111; UNII-6EE945D3OK component IMYZQPCYWPFTAG-NGZCFLSTSA-N; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-, (1R,2S,4S)-

Indication

Disease Entry	ICD 11	Status	REF
Palmar hyperhidrosis	EE00.00	Phase 2	[1]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 203.75
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 1
  Hydrogen Bond Donor Count; 2
  Hydrogen Bond Acceptor Count; 1
• Chemical Identifiers:
  Formula: C11H22ClN
  IUPAC Name: (1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride
  Canonical SMILES: C[C@@]1([C@@H]2CC[C@@H](C2)C1(C)C)NC.Cl
  InChI: InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1
  InChIKey: PKVZBNCYEICAQP-GSTSRXQZSA-N
• Cross-matching ID:
  PubChem CID: 12358971
  CAS Number: 107596-30-5
  UNII: 5Y1141YI4U
  DrugBank ID: DB11807
  TTD ID: D0D7YW

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4)	TT35UGH	ACHA3_HUMAN-ACHB4_HUMAN	Antagonist	[1]
Neuronal acetylcholine receptor beta-2 (CHRNB2)	TT5KPZR	ACHB2_HUMAN	Antagonist	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Palmar hyperhidrosis
• ICD Disease Classification: EE00.00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neuronal acetylcholine receptor beta-2 (CHRNB2)	DTT	CHRNB2	7.10E-08	-0.15	-0.85

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)