Details of the Drug

General Information of Drug (ID: DM8AM60)

Drug Name
TC-5214
Synonyms
Dexmecamylamine; DEXMECAMYLAMINE; UNII-5Y1141YI4U; 107538-05-6; 5Y1141YI4U; TC 5214; (1R,2S,4S)-N,2,3,3-Tetramethylbicyclo(2.2.1)heptan-2-amine; Dexmecamylamine [USAN:INN]; Dexmecamylamine (USAN); CHEMBL2103881; BDBM50045047; ZINC43763856; DB11807; D10111; UNII-6EE945D3OK component IMYZQPCYWPFTAG-NGZCFLSTSA-N; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-, (1R,2S,4S)-
Indication
Disease Entry ICD 11 Status REF
Palmar hyperhidrosis EE00.00 Phase 2 [1]
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 203.75
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 1
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 1
Chemical Identifiers
Formula
C11H22ClN
IUPAC Name
(1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride
Canonical SMILES
C[C@@]1([C@@H]2CC[C@@H](C2)C1(C)C)NC.Cl
InChI
InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1
InChIKey
PKVZBNCYEICAQP-GSTSRXQZSA-N
Cross-matching ID
PubChem CID
12358971
CAS Number
107596-30-5
UNII
5Y1141YI4U
DrugBank ID
DB11807
TTD ID
D0D7YW
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) TT35UGH ACHA3_HUMAN-ACHB4_HUMAN Antagonist [1]
Neuronal acetylcholine receptor beta-2 (CHRNB2) TT5KPZR ACHB2_HUMAN Antagonist [1]
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Molecular Expression Atlas of This Drug

The Studied Disease Palmar hyperhidrosis
ICD Disease Classification EE00.00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neuronal acetylcholine receptor beta-2 (CHRNB2) DTT CHRNB2 7.10E-08 -0.15 -0.85
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)