Details of the Drug

General Information of Drug (ID: DM8P05S)

Drug Name
PS-388023
Synonyms
PS-680648; PS-780035; Angiogenesis inhibitors (ocular indications), Pharmacopeia/Allergan; Angiogenesis inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin avb3/avb5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin alpha-5/beta-3 + alpha-5/beta-5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia
Indication
Disease Entry ICD 11 Status REF
Ocular disease 1F00.1Z Terminated [1]
Cross-matching ID
PubChem CID
59702242
TTD ID
D04YEY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-V/beta-3 (ITGAV/B3) TT69TQN ITAV_HUMAN-ITB3_HUMAN Modulator [2]
Integrin alpha-V/beta-5 (ITGAV/B5) TTPRDH7 ITAV_HUMAN-ITB5_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Ocular disease
ICD Disease Classification 1F00.1Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Integrin alpha-V/beta-5 (ITGAV/B5) DTT ITGAV-ITGB5 2.88E-04 2.42 1.71
Integrin alpha-V/beta-3 (ITGAV/B3) DTT ITGAV-ITGB3 8.19E-02 -0.16 -0.46
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022665)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.