Details of the Drug

General Information of Drug (ID: DM8P05S)

Drug Name

PS-388023

Synonyms

PS-680648; PS-780035; Angiogenesis inhibitors (ocular indications), Pharmacopeia/Allergan; Angiogenesis inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin avb3/avb5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin alpha-5/beta-3 + alpha-5/beta-5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia

Indication

Disease Entry	ICD 11	Status	REF
Ocular disease	1F00.1Z	Terminated	[1]
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Cross-matching ID

PubChem CID: 59702242
TTD ID: D04YEY

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Integrin alpha-V/beta-3 (ITGAV/B3)	TT69TQN	ITAV_HUMAN-ITB3_HUMAN	Modulator	[2]
Integrin alpha-V/beta-5 (ITGAV/B5)	TTPRDH7	ITAV_HUMAN-ITB5_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Ocular disease

ICD Disease Classification

1F00.1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Integrin alpha-V/beta-5 (ITGAV/B5)	DTT	ITGAV-ITGB5	2.88E-04	2.42	1.71
Integrin alpha-V/beta-3 (ITGAV/B3)	DTT	ITGAV-ITGB3	8.19E-02	-0.16	-0.46

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022665)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.