Details of the Drug

General Information of Drug (ID: DM92VRP)

Drug Name
Batimastat
Synonyms
batimastat; 130370-60-4; BB-94; Batimastat (BB-94); BB 94; UNII-BK349F52C9; BB94; Batimastat(BB-94); C23H31N3O4S2; CHEMBL279786; BK349F52C9; Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))-; 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE; (2S,3R)-5-Methyl-3-(((alphaS)-alpha-(methylcarbamoyl)phenethyl)carbamoyl)-2-((2-thienylthio)methyl)hexanohydroxamic acid
Indication
Disease Entry ICD 11 Status REF
Idiopathic pulmonary fibrosis CB03.4 Preclinical [1]
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 477.6
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 12
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C23H31N3O4S2
IUPAC Name
(2S,3R)-N-hydroxy-N'-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide
Canonical SMILES
CC(C)C[C@H]([C@H](CSC1=CC=CS1)C(=O)NO)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NC
InChI
InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChIKey
XFILPEOLDIKJHX-QYZOEREBSA-N
Cross-matching ID
PubChem CID
5362422
CAS Number
130370-60-4
UNII
BK349F52C9
DrugBank ID
DB03880
TTD ID
D0P8YC
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Protein Interaction/Cellular Processes [3]
Furin (FURIN) OTM2665Z FURIN_HUMAN Gene/Protein Processing [4]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [3]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Protein Interaction/Cellular Processes [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 8.5785 11.7173 5.9686 6.5669
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 8.4439 18.2002 2.7059 26.5364
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.6597 8.3959 4.6011 1.6706
GaMG CTRP1 7.4584 9.0493 4.6915 0.453
LN-229 CTRP1 8.8419 15.2771 4.4419 16.8051
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 6.0568 10.0392 3.4592 12.2563
HEC-151 CTRP1 6.0842 20.3401 -0.3157 41.1568
KLE CTRP1 6.7059 12.9658 2.4966 16.8975
HEC-6 CTRP1 6.7759 8.0913 4.773 0.603
HEC-251 CTRP1 6.8585 10.274 3.8838 6.5157
HEC-59 CTRP1 7.756 9.3558 4.6938 0.3102
JHUEM-2 CTRP1 8.4883 12.4317 5.5719 9.9774
HEC-108 CTRP1 8.8486 17.3264 1.8486 14.7356
MFE-319 CTRP1 9.2007 22.0069 -0.1408 22.2317
Ishikawa (Heraklio) 02 ER- CTRP1 7.4817 13.4346 2.8014 12.6613
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WSU-DLCL2 CTRP1 0.9762 3.6263 0.9625 81.8218
PL21 CTRP1 2.5671 12.5705 0.0942 55.9541
P3HR-1 CTRP1 2.9055 7.173 1.9796 37.9382
U-937 CTRP1 3.4913 11.9448 1.3144 51.3268
SU-DHL-5 CTRP1 3.5038 4.6903 3.5027 52.9279
SKM-1 CTRP1 4.431 7.1616 4.1902 40.9102
NOMO-1 CTRP1 4.5576 8.8382 3.7513 41.397
SU-DHL-4 CTRP1 5.0153 9.736 3.8497 37.6716
Ku812 CTRP1 5.1578 8.1423 3.6997 13.7064
OCI-AML-3 CTRP1 5.2753 13.269 2.448 40.1212
MC116 CTRP1 5.5777 6.924 4.6363 3.8266
NU-DUL-1 CTRP1 5.6169 16.4297 1.213 40.8004
MOLM-16 CTRP1 5.7605 12.4773 3.2883 35.2518
KE-97 CTRP1 5.8731 7.9522 4.344 5.44
THP-1 CTRP1 6.0497 10.8224 4.3643 28.845
BL-70 CTRP1 6.0601 7.6335 4.6115 2.7218
GDM-1 CTRP1 6.1275 15.9691 1.8983 37.4135
HT CTRP1 6.1413 10.6118 3.24 13.6625
RPMI-8226 CTRP1 6.1961 10.4237 4.6956 26.0349
EJM CTRP1 8.8449 10.7605 6.5408 1.7748
AMO1 CTRP1 8.8638 10.1204 6.7974 0.4408
LP-1 CTRP1 9.0928 10.3825 6.7908 0.3323
OCI-Ly10 CTRP1 9.5445 14.8493 5.1159 10.3977
KMS-11 CTRP1 10.1663 11.8902 6.6566 0.2557
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.4541 9.0157 4.7019 0.4225
RCC10RGB CTRP1 9.0348 10.4309 6.7513 0.4992
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 CTRP1 -0.2786 22.5272 -7.3272 59.4033
LS513 CTRP1 2.8902 6.5695 2.2105 37.0566
RCM-1 [Human ESC] CTRP1 3.0712 7.3534 2.6531 56.4935
LS180 CTRP1 3.1533 9.6366 1.9454 54.2187
SNU-C4 CTRP1 3.1693 18.4503 -2.0525 51.9006
SW948 CTRP1 3.5817 10.2774 2.1339 50.946
NCI-H508 CTRP1 3.8029 8.3814 3.1167 49.0843
HT-55 CTRP1 3.8675 8.7834 3.0377 48.5233
HT115 CTRP1 4.4672 8.2551 3.8779 41.7419
SW48 CTRP1 6.0616 20.8 -1.8875 34.6383
CL-34 CTRP1 6.2004 9.4143 5.1841 22.5659
LoVo CTRP1 6.2861 11.4983 4.2541 28.2035
DLD-1 CTRP1 6.4824 7.6354 4.823 0.6352
C2BBe1 CTRP1 6.5135 14.1653 1.7664 21.6514
CL-40 CTRP1 6.684 13.485 3.6237 29.4141
SW480 CTRP1 6.8122 13.6328 3.661 28.6725
SW403 CTRP1 6.8198 8.7389 4.5375 1.8322
LS411N CTRP1 7.0701 8.1373 4.8675 0.1489
COLO205 CTRP1 7.1511 8.3525 4.8227 0.221
CW-2 CTRP1 7.1866 15.9868 2.8017 30.5875
SK-CO-1 CTRP1 7.21 14.3987 2.1564 17.3643
SNU-C2A CTRP1 7.3642 12.6742 3.0837 11.089
GP2d CTRP1 7.4651 9.2335 4.6275 0.6769
COLO 678 CTRP1 7.5981 22.8931 -0.3109 36.6463
SNU-61 CTRP1 8.2022 16.5062 3.3603 24.6462
SNU-81 CTRP1 8.24 23.9868 -0.3367 34.972
SNU-1040 CTRP1 8.5599 11.7914 5.9224 6.986
HT-29 CTRP1 8.5801 9.8499 6.7825 0.7367
SNU-C5 CTRP1 8.6139 23.0142 0.4449 32.4805
SW620 CTRP1 8.6711 21.2095 1.3871 30.0557
KM12 CTRP1 8.696 14.3443 4.7921 15.0225
HCT 8 CTRP1 8.8009 9.961 6.8307 0.3613
RKO CTRP1 8.9407 10.596 6.6503 1.0303
HCT 116 CTRP1 9.253 17.9228 3.4456 20.917
COLO 320 CTRP1 9.2751 15.2213 4.7667 13.4593
LS123 CTRP1 9.4017 15.1647 4.8768 12.3843
MDST8 CTRP1 10.6543 18.5502 4.0883 13.9293
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.4119 10.5167 3.4788 10.9395
SNU-398 CTRP1 7.2723 12.8792 4.4268 22.6019
SNU-449 CTRP1 8.2308 14.051 2.9807 9.6437
Hep-G2 CTRP1 9.0471 10.3655 6.7797 0.3918
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1666 CTRP1 1.5221 11.0841 -1.1718 51.0207
EPLC-272H CTRP1 1.7427 8.1462 0.3571 49.7439
NCI-H1568 CTRP1 1.9571 9.4846 -0.0067 48.3348
NCI-H358 CTRP1 2.7577 9.8318 0.6343 42.6251
NCI-H1963 CTRP1 3.0276 10.4156 1.4968 54.6438
NCI-H1781 CTRP1 3.2945 11.4379 1.3377 52.6059
Sq-1 CTRP1 3.6125 12.4247 1.2202 50.5688
NCI-H3255 CTRP1 3.8132 14.5273 0.4415 49.4894
COR-L51 CTRP1 4.7102 74.11 -28.3457 49.2087
LCLC-97TM1 CTRP1 6.0033 11.5084 2.6946 18.025
NCI-H82 CTRP1 6.0122 8.3087 4.267 5.6818
BEN CTRP1 6.0214 7.0559 4.8429 1.1031
HCC4006 CTRP1 6.0278 23.9139 -2.1469 43.0327
NCI-H2141 CTRP1 6.0824 9.8143 4.8799 25.4273
Lu-65 CTRP1 6.0906 11.1743 2.9257 16.1334
HCC33 CTRP1 6.1058 8.106 4.4226 4.1256
Calu-6 CTRP1 6.1796 8.6406 4.2193 5.6041
NCI-H1975 CTRP1 6.281 9.761 3.7529 9.1617
NCI-H2126 CTRP1 6.3035 10.0709 3.619 10.1724
NCI-H23 CTRP1 6.3369 13.0669 2.1762 20.0356
NCI-H2029 CTRP1 6.3469 10.6642 3.362 12.0486
NCI-H1299 CTRP1 6.4088 12.851 2.3363 18.8542
Lu-99 CTRP1 6.4496 8.4141 4.4845 2.8471
SHP-77 CTRP1 6.5304 8.8499 4.3366 3.7889
NCI-H2286 CTRP1 6.5506 10.5441 3.5601 9.883
NCI-H2009 CTRP1 6.5563 11.6441 3.0337 13.8004
NCI-H1355 CTRP1 6.5868 9.7616 3.9532 6.6675
DMS 273 CTRP1 6.5982 11.9259 2.9264 14.4187
Calu-3 CTRP1 6.6282 10.4096 3.6754 8.7552
NCI-H2342 CTRP1 6.6748 13.172 3.7717 28.7754
NCI-H1930 CTRP1 6.7522 8.347 4.6643 1.1692
CAL-12T CTRP1 6.7856 21.0962 -0.0903 38.6643
COR-L88 CTRP1 6.7954 10.1448 3.9048 6.5107
NCI-H1048 CTRP1 6.8329 9.5989 4.1745 4.3553
EBC-1 CTRP1 6.8334 14.5753 1.8013 20.4387
NCI-H522 CTRP1 6.8614 13.7273 2.2364 17.9674
NCI-H1573 CTRP1 6.9094 13.7024 2.2828 17.547
HCC78 CTRP1 6.9448 12.4273 2.9243 13.3651
COR-L279 CTRP1 6.9726 8.2991 4.7749 0.4528
RERF-LC-KJ CTRP1 7.0207 14.7236 1.8644 19.5284
COLO 668 CTRP1 7.0394 15.9219 1.2912 22.2652
NCI-H1793 CTRP1 7.0567 9.0094 4.5395 1.4959
NCI-H1437 CTRP1 7.0644 13.1113 2.6771 14.6491
LCLC-103H CTRP1 7.0802 8.8575 4.6097 1.0904
HARA [Human squamous cell lung carcinoma] CTRP1 7.1101 14.3117 2.1285 17.8199
ChaGo-K-1 CTRP1 7.3215 15.4702 1.7149 19.4004
NCI-H1373 CTRP1 7.3268 9.2695 4.5572 1.1019
A-549 CTRP1 7.3314 10.932 3.8633 5.5778
NCI-H441 CTRP1 7.3395 15.0086 3.4177 27.5622
KNS-62 CTRP1 7.3682 10.1397 4.2261 2.9789
VMRC-LCD CTRP1 7.4381 8.8026 4.7705 0.2418
NCI-H810 CTRP1 7.4751 8.9514 4.7323 0.324
NCI-H1915 CTRP1 7.5515 8.9115 4.7735 0.1987
NCI-H1694 CTRP1 7.5883 16.0137 3.119 27.8665
NCI-H1944 CTRP1 7.6127 14.2607 2.4959 14.2261
HCC44 CTRP1 7.6153 15.0516 2.1203 16.4071
LXF 289 CTRP1 7.6434 14.7346 2.2907 15.3601
NCI-H2122 CTRP1 7.6682 12.4574 4.9573 17.4784
DV-90 CTRP1 7.7673 9.39 4.6861 0.3254
NCI-H1105 CTRP1 7.8181 57.7292 -17.5451 45.4993
NCI-H1435 CTRP1 7.8886 16.9153 1.4109 19.2936
NCI-H650 CTRP1 7.9018 9.3132 4.7594 0.1378
HCC2935 CTRP1 7.9161 18.6938 2.045 30.4748
NCI-H727 CTRP1 8.1213 18.3644 0.8722 21.0533
NCI-H661 CTRP1 8.2087 15.9876 2.068 15.125
NCI-H1836 CTRP1 8.2106 17.1968 3.0236 26.0572
LC-1/sq-SF CTRP1 8.2847 15.6252 2.2871 13.7169
NCI-H1792 CTRP1 8.3149 15.7268 2.2586 13.804
NCI-H2405 CTRP1 8.4078 10.3879 4.5719 0.3648
NCI-H596 CTRP1 8.4553 11.4383 6.0212 6.4734
HCC1359 CTRP1 8.5212 9.4684 6.9005 0.2869
COR-L23 CTRP1 8.571 11.6491 5.9957 6.3709
NCI-H2081 CTRP1 8.5883 10.7499 6.4133 3.0906
NCI-H460 CTRP1 8.6522 9.966 6.7688 0.7325
NCI-H1755 CTRP1 8.6902 12.2659 5.783 7.738
HCC15 CTRP1 8.8976 15.5346 4.3561 17.1502
NCI-H2023 CTRP1 8.9675 12.5114 5.8408 6.5777
SCLC-21H CTRP1 8.9882 10.7101 6.6268 1.1007
NCI-H2110 CTRP1 9.0154 29.6047 -2.521 36.3568
HCC2108 CTRP1 9.0449 14.887 4.7717 14.0915
NCI-H841 CTRP1 9.1179 10.6906 6.6889 0.6871
T3M-10 CTRP1 9.1575 17.1745 3.7424 19.7459
NCI-H1876 CTRP1 9.198 21.0649 1.8611 27.1984
SK-LU-1 CTRP1 9.6263 15.8321 4.7076 12.876
HCC827 CTRP1 10.042 17.0268 4.4129 13.5956
NCI-H2172 CTRP1 10.504 20.0735 3.2725 18.3484
HCC1833 CTRP1 10.5955 21.5054 2.6486 20.7682
HCC1195 CTRP1 10.7604 16.9525 4.8823 9.1115
NCI-H2030 CTRP1 11.6052 21.5384 3.2929 15.7223
COLO 699 CTRP1 11.8875 23.4993 2.555 18.2205
NCI-H2073 CTRP1 12.0115 23.6669 2.5556 17.9602
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CTRP1 6.0409 11.729 2.614 18.4162
KYSE-410 CTRP1 7.0467 17.0034 0.7648 24.4587
KYSE-450 CTRP1 7.8176 13.8055 2.8418 11.5229
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 CTRP1 5.2369 15.9973 1.0799 42.5714
OVCAR-8 CTRP1 5.9352 23.3766 -1.9591 43.1441
COV644 CTRP1 6.0251 14.3707 2.5996 36.1021
COV318 CTRP1 6.4018 7.9177 4.6725 1.6112
JHOS-4 CTRP1 6.5314 12.3786 2.658 16.4374
OVMANA CTRP1 6.6112 7.9864 4.7431 0.9049
COV362 CTRP1 6.619 17.3976 1.6154 36.1284
OV-90 CTRP1 6.9413 17.3193 1.9293 34.1737
SK-OV-3 CTRP1 7.303 8.6932 4.7594 0.3246
RMG-I CTRP1 7.5442 24.6891 -1.253 38.142
EFO-21 CTRP1 7.6219 9.1348 4.7219 0.2915
HEY A8 CTRP1 7.9591 13.0709 3.2649 8.3913
OVKATE CTRP1 8.0518 11.9315 5.5083 11.8831
OAW42 CTRP1 8.4531 9.2832 6.9406 0.1971
SNU-840 CTRP1 8.549 16.9037 3.4284 23.1766
Caov-3 CTRP1 8.6457 15.1055 4.385 17.7763
RMUG-S CTRP1 8.7815 17.775 3.1727 23.5816
OV7 CTRP1 8.7824 14.6629 4.6983 15.371
A2780 CTRP1 9.0725 14.2152 5.111 11.7002
JHOM-1 CTRP1 9.116 18.4406 3.0927 22.9094
OVK18 CTRP1 9.1459 22.9714 0.8784 30.0782
TYK-nu CTRP1 9.7548 11.4751 6.6517 0.425
COV434 CTRP1 10.174 19.2479 3.4456 18.379
JHOC-5 CTRP1 10.4007 26.5613 0.0471 29.0286
IGROV-1 CTRP1 10.4997 19.8723 3.3656 17.9313
EFO-27 CTRP1 10.8752 23.2234 2.0133 22.4482
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 CTRP1 6.6463 9.684 4.026 5.9372
HuP-T4 CTRP1 6.723 14.6201 1.6982 21.3136
HPAC CTRP1 6.8038 10.2805 3.8474 6.9362
QGP-1 CTRP1 6.9361 12.0544 3.097 12.1912
PaTu 8902 CTRP1 7.0867 12.0958 3.1769 11.1943
Panc 10.05 CTRP1 7.4041 14.7005 2.145 16.8634
Panc 03.27 CTRP1 7.4427 14.5349 2.251 16.1492
CFPAC-1 CTRP1 7.9202 14.834 2.4253 13.8346
KP-3 CTRP1 8.0201 16.8975 1.5094 18.4756
Capan-2 CTRP1 8.4493 16.2317 2.1077 14.3135
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 6.6414 11.4991 3.1632 12.6021
NCI-H28 CTRP1 7.35 13.7685 2.5556 14.5888
NCI-H2052 CTRP1 7.4617 13.0004 2.9929 11.4475
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 8.3214 13.6855 3.1979 8.046
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-361 CTRP1 6.1772 9.2934 3.9069 8.214
Hs 852.T CTRP1 6.3766 8.2661 4.5093 2.8122
COLO 741 CTRP1 7.082 14.3677 2.0815 18.168
Hs 936.T CTRP1 7.1112 8.1847 4.8658 0.1409
Hs 944.T CTRP1 7.3631 10.9025 3.8941 5.2884
A-375 CTRP1 8.6278 10.3326 6.6117 1.6519
SK-MEL-5 CTRP1 8.7942 13.5698 5.2333 11.6295
SK-MEL-1 CTRP1 9.1983 17.1927 3.7626 19.521
SK-MEL-28 CTRP1 10.5853 23.0614 1.8901 23.5466
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 7.4172 16.4138 1.3236 21.0064
HT-1080 CTRP1 8.7393 12.1876 5.8505 7.0788
RKN CTRP1 10.0536 16.1704 4.819 11.0867
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 CTRP1 5.7347 8.5921 3.9334 9.4443
MKN7 CTRP1 5.8794 15.7914 0.4659 29.2506
SH-10-TC CTRP1 6.4203 7.9224 4.6798 1.5342
Fu97 CTRP1 6.5437 8.1368 4.6515 1.5262
MKN74 CTRP1 6.8641 12.1584 2.9985 13.0953
AGS CTRP1 7.2938 19.0999 1.3344 34.4071
SNG-M CTRP1 6.9132 10.3548 3.8798 6.412
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 CTRP1 2.914 14.4195 -0.3932 53.656
HSC-2 CTRP1 5.6202 10.5569 2.8699 18.2825
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 CTRP1 3.2734 9.9906 1.0615 38.6267
5637 CTRP1 5.0762 13.6342 0.8856 30.7182
RT-4 CTRP1 6.1064 15.6761 0.7035 27.6467
KMBC-2 CTRP1 6.1385 16.2122 0.4619 28.4021
UM-UC-3 CTRP1 7.1321 10.3839 3.9944 5.0481

References

1 Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855.
2 Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 1994 Sep 1;54(17):4726-8.
3 Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation. Chem Biol Interact. 2016 Jun 25;253:38-47. doi: 10.1016/j.cbi.2016.04.031. Epub 2016 Apr 23.
4 Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP. J Cell Sci. 2005 Jan 15;118(Pt 2):343-56. doi: 10.1242/jcs.01613. Epub 2005 Jan 4.