Details of the Drug

General Information of Drug (ID: DM93YKJ)

Drug Name
VX-680
Synonyms
Tozasertib; MK 0457; VX 680; VX6; L-001281814; MK-045; MK-0457; Tozasertib (USAN); VX-68; MK-0457, Tozasertib, VX680, VX-680; N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide; N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid N-(4-((4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl)sulfanyl)phenyl)amide; Cyclopropane carboxylic acid{4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulphanyl]-phenyl}-amide; Cyclopropanecarboxylic Acid {4-[4-(4-Methyl-Piperazin-1-Yl)-6-(5-Methyl-2h-Pyrazol-3-Ylamino)-Pyrimidin-2-Ylsulfanyl]-Phenyl}-Amide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 464.6
Logarithm of the Partition Coefficient (xlogp) 3.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C23H28N8OS
IUPAC Name
N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
Canonical SMILES
CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C
InChI
InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
InChIKey
GCIKSSRWRFVXBI-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5494449
ChEBI ID
CHEBI:91336
CAS Number
639089-54-6
TTD ID
D02XNW
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aurora kinase A (AURKA) TTPS3C0 AURKA_HUMAN Inhibitor [2]
Aurora kinase B (AURKB) TT5LS6T AURKB_HUMAN Inhibitor [2]
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Post-Translational Modifications [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Post-Translational Modifications [4]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aurora kinase A (AURKA) DTT AURKA 9.41E-46 -1.78 -2.05
Aurora kinase B (AURKB) DTT AURKB 3.52E-36 -0.82 -1.62
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 -0.0814 7.8899 -2.6522 34.9873
OCI-AML-5 CTRP2 -6.514 -4.8451 -6.514 83.469
SEM CTRP2 -6.3794 -5.8152 -6.3794 82.7688
697 GDSC1 -5.8282 -4.3196 -5.8283 83.9222
ALL-SIL GDSC1 -5.7396 -3.902 -5.7401 82.1558
GA-10 GDSC1 -5.3881 -3.7109 -5.3885 78.7636
SUP-B8 GDSC2 -5.3338 -3.9604 -5.3338 76.6716
RS4;11 GDSC1 -5.1477 2.1657 -6.0602 64.0867
MOLM-13 GDSC1 -4.9545 -2.3404 -4.9704 72.0795
KE-97 CTRP1 -4.9335 6.5911 -6.3 76.8225
P32/ISH GDSC1 -4.8359 -3.531 -4.8359 72.757
OCI-Ly19 GDSC1; GDSC2 -4.5854 -2.8582 -4.5856 69.1569
RCH-ACV GDSC2 -4.5357 1.0019 -4.8474 63.961
KOPN-8 GDSC1 -4.2965 -1.3354 -4.3485 64.4082
SR GDSC1 -4.2649 -3.5256 -4.2649 65.8099
Kasumi-2 CTRP2 -4.2376 6.0864 -5.1882 62.0732
BE-13 GDSC1 -4.0845 -1.6612 -4.1063 62.7461
NB4 GDSC1; GDSC2 -4.0722 3.2415 -4.9274 58.9043
CRO-AP2 GDSC2 -3.8506 0.496 -4.018 60.0766
MV4-11 GDSC1 -3.6969 -0.6534 -3.7872 57.7587
NALM-6 GDSC1 -3.6822 3.7312 -5.0487 54.5248
MY-M12 GDSC1; GDSC2 -3.5998 0.0092 -3.6867 58.5179
SU-DHL-16 GDSC1; GDSC2 -3.4762 2.7735 -4.1346 55.7448
BV-173 GDSC1 -3.4463 -0.9371 -3.492 55.2453
SIG-M5 GDSC1; GDSC2 -3.3073 -2.3627 -3.3073 56.4898
DoHH2 GDSC1; GDSC2 -3.2122 0.4937 -3.3345 54.9788
MOLT-4 GDSC1 -3.1848 2.4712 -4.0391 51.5036
Karpas-231 GDSC1 -3.1564 0.5451 -3.4204 51.6222
SUP-M2 GDSC1 -3.0271 1.1997 -3.451 50.2631
NU-DUL-1 GDSC1; GDSC2; CTRP1 -2.8457 0.6757 -2.8687 61.705
A4/Fukuda GDSC1 -2.7693 4.5723 -4.4371 48.4549
MC116 GDSC1; GDSC2; CTRP1 -2.5796 1.1282 -2.6157 59.6339
Mono-Mac-6 GDSC1 -2.517 2.5999 -3.369 45.8081
Ku812 GDSC1; CTRP1 -2.5145 -0.6306 -2.5148 62.7665
SUP-B15 GDSC1 -2.3623 2.2585 -3.0763 44.1197
BL-41 GDSC1 -2.3338 3.0028 -3.3298 44.3822
H9 GDSC1 -2.2871 3.0696 -3.3068 44.0055
SU-DHL-8 GDSC1 -2.2657 18.5714 -10.6364 48.0934
MOLM-16 GDSC2; CTRP1 -2.1902 6.087 -3.1552 54.848
OCI-Ly7 GDSC2 -1.8803 1.0613 -1.9916 42.5596
KCL-22 GDSC1 -1.8293 2.7513 -2.695 39.2398
Namalwa GDSC1 -1.7882 6.9858 -4.546 43.0321
EoL-1 GDSC1 -1.6919 3.5038 -2.8626 38.8857
AML-193 CTRP2 -1.6343 10.6969 -3.9439 50.6757
EM-2 GDSC1 -1.6062 1.8525 -2.1154 35.3866
BONNA-12 GDSC2 -1.5976 8.9876 -4.6554 44.9439
QIMR-WIL GDSC1; GDSC2 -1.586 5.3983 -3.0499 42.9769
LAMA-84 GDSC1 -1.461 1.2417 -1.7554 32.5428
BL-70 CTRP1 -1.366 7.5694 -2.7691 66.3587
MHH-CALL-4 GDSC2 -1.2973 9.6366 -4.6623 43.7021
KE-37 GDSC1 -1.1931 5.3768 -3.2061 37.0643
K-562 GDSC1 -1.1209 1.4782 -1.4609 28.686
CCRF-CEM GDSC1 -0.9846 6.8733 -3.7192 37.4635
ALL-PO GDSC1 -0.8664 3.5604 -2.0416 30.56
TALL-1 [Human adult T-ALL] GDSC2 -0.8517 5.5646 -2.3572 37.6325
KMS-11 GDSC2; CTRP1 -0.8286 3.7556 -1.0632 46.6852
CTV-1 GDSC1 -0.7737 2.5321 -1.4951 26.918
JSC-1 GDSC1 -0.6696 11.3315 -5.6156 39.9199
OCI-AML-2 GDSC1 -0.6454 2.8984 -1.5211 26.3859
GDM-1 GDSC1; CTRP1 -0.4627 4.2608 -0.7693 46.2731
ML-2 GDSC1 -0.3729 9.2263 -4.3067 36.2727
Farage GDSC1; GDSC2 -0.3035 5.5926 -1.808 33.2472
NKM-1 GDSC1 -0.2744 6.2822 -2.7661 30.9394
OCI-AML-5 GDSC1 -0.1736 4.9415 -2.0177 26.9102
NOMO-1 GDSC1; CTRP1 -0.0578 7.461 -1.3255 44.6652
M-07e CTRP2 0.022 7.5004 -0.9763 42.1285
P3HR-1 CTRP1 0.0455 26.7134 -10.1856 53.0915
JeKo-1 GDSC2 0.0752 10.4118 -3.7199 36.9643
MOLT-16 GDSC1 0.109 8.173 -3.3536 31.5273
BC-3 GDSC1; GDSC2 0.2285 9.6539 -3.2074 35.2363
JJN-3 CTRP2 0.2435 4.9719 -0.029 39.3856
KMS-20 CTRP2 0.2535 12.3981 -2.6843 43.288
ATN-1 GDSC1 0.2656 8.0872 -3.1728 30.235
SU-DHL-5 CTRP1 0.2832 17.0213 -5.2536 54.1053
SU-DHL-6 GDSC1 0.2853 9.2214 -3.7205 32.0606
Karpas-620 GDSC1 0.3105 14.1739 -6.17 37.563
HuT 78 CTRP2 0.3375 7.1905 -0.5306 40.0857
Karpas-422 GDSC1 0.4541 14.0266 -5.9736 36.7986
DEL GDSC1 0.4837 6.2548 -2.0691 24.2946
SKM-1 GDSC1; GDSC2; CTRP1 0.5651 2.4979 0.5546 35.4194
NU-DHL-1 CTRP2 0.6394 8.073 -0.5105 38.8822
MEG-01 GDSC1 0.6836 5.6018 -1.5696 20.5516
OCI-M1 GDSC1 0.7686 4.0039 -0.6989 14.1668
CTB-1 GDSC1; GDSC2 0.7977 7.728 -1.7369 28.3957
F-36P CTRP2 0.8459 9.7384 -0.9371 38.9341
HAL-01 GDSC1 0.8809 4.5593 -0.8799 15.0749
HC-1 GDSC1 1.1977 9.0201 -2.8465 25.3864
Karpas-45 GDSC1 1.2185 16.0537 -6.3456 35.2594
PL21 CTRP1 1.2249 6.1567 0.5307 53.1102
DND-41 GDSC1 1.2286 8.5287 -2.5756 24.0321
JJN-3 GDSC1 1.2891 6.3235 -1.4248 17.3434
PF-382 GDSC1 1.3917 6.5878 -1.4746 17.3047
RPMI-8402 GDSC1 1.3953 9.446 -2.8983 24.9297
BALL-1 GDSC1 1.4521 7.9309 -2.0963 20.791
Daudi GDSC1 1.4751 10.3887 -3.3045 26.3482
WIL2 NS GDSC1 1.5897 7.0771 -1.5622 17.184
Loucy GDSC1 1.7045 10.6019 -3.2272 25.2938
Kasumi-1 GDSC1; GDSC2 1.7165 2.4707 1.6153 6.6209
DND-41 CTRP2 1.7189 8.7598 0.3801 32.9915
NK-92MI GDSC1; GDSC2 1.8192 4.9864 0.5506 12.7476
HEL GDSC1; GDSC2 1.8304 6.3186 -0.0995 16.6251
OPM-2 GDSC1 1.9225 6.7994 -1.1714 13.5663
OCI-AML-3 GDSC1; CTRP1 1.9648 4.3948 1.8376 26.1979
HL-60 GDSC1 1.9787 8.5744 -2.0057 18.5496
LC4-1 GDSC1 1.9797 10.8572 -3.1378 24.059
KM-H2 GDSC1 1.9886 5.8116 -0.64 9.6388
KY821 GDSC1 2.0228 9.1376 -2.2511 19.7455
A3/Kawakami GDSC1 2.0248 8.5181 -1.9429 18.0495
Jiyoye GDSC1 2.1245 8.336 -1.7783 16.7864
SU-DHL-1 GDSC1; GDSC2 2.1705 6.8284 -0.0588 15.3126
RL GDSC1; GDSC2 2.1805 3.6053 1.5589 5.2584
HH [Human lymphoma] GDSC1 2.2959 9.0063 -1.9812 17.4374
KG-1 GDSC1 2.3735 4.4404 0.2446 2.4549
Raji GDSC1 2.3763 6.6446 -0.7741 9.5283
CESS GDSC1 2.3884 9.4756 -2.1437 18.0587
P31/FUJ GDSC1 2.3915 3.4444 0.6549 0.3198
Granta-519 GDSC1 2.4201 9.4757 -2.1204 17.8391
MHH-PREB-1 GDSC1 2.4918 9.4873 -2.0737 17.3747
DG-75 GDSC1 2.5269 5.6382 -0.2039 5.1614
SK-MM-2 GDSC1 2.5529 6.5404 -0.6076 7.9169
ARH-77 GDSC1 2.6562 7.8585 -1.1665 11.4408
L-540 GDSC1 2.6723 9.5318 -1.9653 16.2581
ST486 GDSC1 2.6981 11.7413 -3.0296 21.4763
PL-21 GDSC1; GDSC2 2.8223 10.9782 -1.5966 21.2355
U-937 CTRP1 2.8229 8.3452 1.3156 39.2738
L-363 GDSC1 2.8352 8.3567 -1.2842 11.7313
KMOE-2 GDSC1 2.8726 9.3054 -1.7146 14.2685
SCC-3 GDSC1 2.8742 9.3783 -1.7487 14.4637
IM-9 GDSC1 2.9657 4.2868 0.5719 0.2805
L-1236 GDSC1 2.972 5.9996 -0.1107 3.6795
CA46 GDSC1 2.9886 8.8061 -1.396 12.04
DB GDSC1 2.9908 4.9146 0.3492 1.0721
Ramos.2G6.4C10 GDSC1 3.0046 15.0646 -4.4396 25.889
Karpas-299 GDSC1 3.0356 4.5747 0.4956 0.4662
YT GDSC1 3.0365 4.6956 0.4516 0.6157
RPMI-6666 GDSC1 3.0482 8.467 -1.1957 10.6322
MN-60 GDSC1 3.0685 5.0591 0.327 1.0992
EB2 GDSC1 3.1079 4.6005 0.5141 0.373
Reh GDSC1 3.1084 9.6867 -1.7367 13.7786
Hs 445 GDSC1 3.1481 11.1235 -2.4026 17.2926
SUP-T1 GDSC1 3.1799 4.9143 0.4283 0.6046
P30/OHK GDSC1 3.1902 5.0347 0.3878 0.7451
THP-1 GDSC1; GDSC2; CTRP1 3.2224 7.8051 1.963 20.0635
GR-ST GDSC1 3.2814 10.3816 -1.9527 14.5624
MLMA GDSC1 3.3063 5.1254 0.401 0.6194
U-698-M GDSC1 3.3765 5.8872 0.1387 1.6801
JVM-3 GDSC1 3.3795 4.9361 0.4967 0.3028
L-428 GDSC1 3.4189 5.3496 0.3634 0.6787
TUR GDSC1 3.4221 4.8421 0.5444 0.1882
WSU-NHL GDSC1 3.5086 5.2779 0.4242 0.4369
U266B1 CTRP2 3.5103 13.3933 0.0912 28.5711
VL51 GDSC1 3.5563 14.3024 -3.6599 21.7803
RPMI-8866 GDSC1 3.5649 5.4178 0.3956 0.4918
KMS-12-BM GDSC1 3.5694 11.5686 -2.3267 15.8309
WSU-DLCL2 GDSC1; CTRP1 3.5826 4.8041 3.5095 12.5551
JVM-2 GDSC1 3.7055 5.9043 0.2734 0.8106
HDLM-2 GDSC1 3.7246 5.4811 0.4328 0.3254
U266B1 GDSC1 3.7708 11.3832 -2.1038 14.1831
BC-1 GDSC1 3.8647 5.6642 0.42 0.3052
SUP-HD1 GDSC1 3.9653 14.0763 -3.2623 19.1956
LP-1 GDSC1; GDSC2; CTRP1 3.9849 8.6976 2.282 16.3811
ME1 GDSC1 3.9874 14.7085 -3.5525 20.3186
AMO1 GDSC1; CTRP1 4.4095 12.6499 0.7095 22.9159
EJM GDSC1; CTRP1 4.4215 9.053 2.5086 14.8805
L-428 CTRP2 4.4234 14.3975 0.4504 25.2982
OCI-Ly10 CTRP1 4.7952 11.4187 1.6566 27.3956
RPMI-8226 GDSC1; CTRP1 4.9376 15.1828 -0.1045 24.4293
EHEB GDSC1 4.9908 14.3059 -2.694 14.4115
HT GDSC1; GDSC2; CTRP1 5.2444 13.74 0.872 19.3107
MOLP-8 GDSC1 5.4131 21.3878 -5.7915 24.3886
SU-DHL-4 GDSC1; GDSC2; CTRP1 5.4873 16.1508 -0.1342 22.3625
ROS-50 GDSC1; GDSC2 5.9043 16.4679 -2.0344 15.9412
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1; GDSC2 0.142 3.1119 -0.3115 24.2986
TE-12 GDSC1; GDSC2 1.8039 8.6948 -1.3059 23.0105
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 2.2966 12.2714 -3.595 24.9207
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-5 GDSC1 -2.9785 0.2539 -3.1632 49.764
KP-N-YS GDSC1; GDSC2 -0.7722 2.1357 -1.0059 32.2004
SK-N-DZ GDSC1 -0.0254 2.4299 -0.6815 17.4844
SK-N-MC-IXC GDSC2 0.1193 4.277 -0.7987 26.9515
SJNB-6 GDSC1; GDSC2 0.2842 6.767 -1.7646 30.5278
MHH-NB-11 GDSC1; GDSC2 0.4129 4.8561 -0.751 25.4519
SJNB-13 GDSC1 0.7635 6.8364 -2.1175 23.4348
SJNB-17 GDSC1; GDSC2 0.8205 5.5579 -0.6706 23.3943
KP-N-YN GDSC1 0.8507 8.4399 -2.8451 26.6365
TGW GDSC1 1.026 4.4313 -0.694 13.1576
SK-N-FI GDSC1 1.1626 3.2615 0.0017 7.301
SK-N-BE(2)-M17 GDSC1 1.7414 7.4962 -1.6528 17.2428
NB(TU)1 GDSC1 1.9124 6.1264 -0.8482 11.3573
NB69 GDSC1 2.3605 8.2646 -1.5703 14.8279
SJNB-5 GDSC1; GDSC2 2.3749 6.7726 0.1406 13.5233
NB1 GDSC1 2.4944 15.5932 -5.0917 29.0995
GOTO GDSC1 2.5314 8.9581 -1.7863 15.6312
Kelly GDSC1 2.5503 7.3292 -0.9845 10.512
KP-N-RT-BM-1 GDSC1; GDSC2 2.5747 13.1483 -2.8821 26.7645
CHP-126 GDSC1; GDSC2 2.6246 13.4438 -2.9888 26.9669
GI-ME-N GDSC1 2.6358 26.1587 -10.2435 37.2731
SJNB-14 GDSC1 2.6981 7.3296 -0.8861 9.4693
SK-N-BE(2) CTRP2 2.767 10.4779 0.7316 28.7725
SJNB-7 GDSC1 2.9252 4.5451 0.4624 0.6531
SJNB-10 GDSC1 3.2484 5.0052 0.4221 0.583
NH-12 GDSC1 3.4688 5.1695 0.4477 0.3905
SiMa GDSC1 3.626 5.7496 0.2987 0.7727
LA-N-6 GDSC1; GDSC2 3.8648 12.27 -1.4322 17.7926
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES8 GDSC1 -5.8066 -4.4065 -5.8066 83.9442
SK-ES-1 CTRP2 -4.5473 -1.7412 -4.5479 70.3022
SK-ES-1 GDSC1 -2.6264 1.8186 -3.2079 46.4698
EW-16 GDSC1 -2.0652 7.7149 -5.1605 45.0912
MHH-ES-1 GDSC2 -1.5497 6.2801 -3.3874 43.3033
SK-PN-DW GDSC1 -0.495 6.1789 -2.9209 32.5827
ES4 GDSC1 -0.0806 4.7554 -1.84 25.4834
EW-1 GDSC1 0.2703 6.6789 -2.4683 27.2192
NOS-1 [Human HNSCC] GDSC1 0.3466 1.6722 0.0346 10.3663
ES1 GDSC1 1.3227 5.9763 -1.2246 15.8955
ES6 GDSC1 1.5125 3.8085 -0.0034 6.236
EW-12 GDSC1; GDSC2 1.7295 3.1291 1.359 8.0709
ES5 GDSC1; GDSC2 1.8427 3.3778 1.3559 7.669
SaOS-2 CTRP2 1.8441 7.3481 1.0483 30.6221
H-EMC-SS GDSC1 2.0917 4.7159 -0.0461 5.0256
CHSA0011 GDSC2 2.1109 9.3899 -1.3894 22.4138
G-292 clone A141B1 CTRP2 2.1283 5.4108 1.9255 26.7819
EW-3 GDSC1 2.2175 5.1166 -0.1537 5.5038
EW-18 GDSC1 2.4617 9.4394 -2.0722 17.454
TC-71 GDSC1 2.5259 4.6208 0.2475 2.1901
EW-24 GDSC1 2.5455 3.8631 0.562 0.5489
SJSA-1 GDSC1 2.5601 9.4006 -1.9818 16.6683
U-CH2 GDSC2 3.3453 8.2754 0.149 10.8857
EW-13 GDSC1 3.4877 5.7344 0.2473 1.075
ES7 GDSC1 3.5216 6.2639 0.0548 1.9392
U2OS GDSC2; CTRP1 3.7891 8.3261 2.2755 16.9592
CHSA0108 GDSC2 4.6593 14.4308 -1.9124 18.0076
Hs 888.T CTRP2 4.8054 7.474 4.146 10.7453
EW-11 GDSC1 5.1443 7.5599 0.2254 0.313
Hs 822.T CTRP2 6.4498 8.9421 4.9179 4.0078
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 89 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1; GDSC2 -2.373 2.6741 -2.9021 47.5719
DU4475 GDSC1; GDSC2 0.3474 4.2293 -0.5418 24.5579
MDA-MB-468 GDSC2 1.4556 11.2242 -2.8703 29.9975
MFM-223 GDSC1; GDSC2 2.3193 6.4247 0.2684 12.8756
HCC2157 GDSC1 2.3536 4.7401 0.1012 3.4294
HCC1569 GDSC2 2.4576 11.1878 -1.9984 23.8835
CAL-120 GDSC2 2.9218 10.2799 -1.1689 18.9628
HCC2218 GDSC1; GDSC2 2.9234 5.1079 1.3928 4.3317
CAL-51 GDSC2 3.2223 14.5354 -3.0516 25.5307
HDQ-P1 GDSC2 3.3056 5.062 1.6589 2.0486
HCC1187 GDSC1; GDSC2 3.3355 12.1802 -1.7901 20.6238
Hs 578T GDSC2 3.4294 9.2409 -0.2635 12.9772
MDA-MB-157 CTRP2 3.4517 11.6953 0.8472 26.5284
Evsa-T GDSC1; GDSC2 3.4807 7.8801 0.4394 8.8354
HCC1143 GDSC2 3.5146 8.0367 0.3872 9.0651
MCF-7 GDSC2; CTRP1 3.5197 10.9554 0.7468 24.1858
BT-549 GDSC2 3.5637 10.921 -0.9917 16.4271
HCC38 GDSC2 3.5736 7.4936 0.6902 7.1511
YMB-1-E GDSC2 3.6037 10.7408 -0.8729 15.7867
BT-474 GDSC1; GDSC2 3.6414 9.1559 -0.0676 11.3818
HCC1428 GDSC2 3.6925 9.1316 -0.0193 10.9933
HCC1806 GDSC2 3.7058 5.9938 1.4706 2.4459
HCC1395 GDSC2 3.723 14.7803 -2.7816 23.3937
MDA-MB-231 GDSC2 3.7623 11.35 -1.0551 16.2449
CAL-148 GDSC1; GDSC2 3.8363 12.4311 -1.5328 18.262
MDA-MB-157 GDSC2 3.9068 6.5174 1.3513 2.7778
MDA-MB-361 GDSC2 3.9121 7.0946 1.0945 4.1646
HCC70 GDSC2 3.9985 13.0515 -1.7178 18.6697
HCC1599 GDSC1; GDSC2 4.0185 11.6755 -1.0274 15.5006
EFM-19 GDSC2 4.0624 9.0345 0.2818 8.4908
MDA-MB-453 GDSC2 4.1291 6.7401 1.375 2.3483
HCC1500 GDSC2 4.1722 6.1569 1.6394 1.0956
HCC1937 GDSC2 4.2009 8.4822 0.6314 6.2493
HCC1419 GDSC2 4.2825 5.9439 1.77 0.5455
ZR-75-30 GDSC2 4.3062 6.0011 1.7584 0.5675
MDA-MB-436 GDSC2 4.3336 6.8964 1.4139 1.9125
CAMA-1 GDSC2 4.4479 10.3571 -0.092 9.7652
HCC1954 GDSC2 4.5647 6.5968 1.6408 0.7841
UACC-893 GDSC2 4.5903 12.3409 -0.9463 13.8289
AU565 GDSC2 4.6004 7.6911 1.2142 2.5382
COLO 824 GDSC1; GDSC2 4.687 12.2259 -0.8246 13.0347
JIMT-1 GDSC2 4.7491 6.3957 1.7879 0.2882
MDA-MB-415 GDSC2 4.7672 6.2723 1.8375 0.1903
EFM-192A GDSC2 4.8578 6.8303 1.6734 0.5174
MDA-MB-330 GDSC2 4.896 9.8089 0.4438 6.0637
MDA-MB-175-VII GDSC2 4.9106 6.3378 1.8657 0.1196
BT-483 GDSC2 4.9543 6.7886 1.7257 0.3491
MRK-nu-1 GDSC1; GDSC2 5.1805 15.7851 -2.2018 17.9971
CAL-85-1 GDSC2 5.36 7.3876 1.6653 0.3368
MDA-MB-453 CTRP2 5.4715 8.5071 4.3082 8.4841
MDA-MB-361 CTRP2 5.4763 10.6118 3.2716 25.4161
HCC2218 CTRP2 5.5306 9.4159 3.9134 9.9977
Hs 578Bst CTRP2 5.5419 16.2347 0.5247 22.5853
BT-474 CTRP2 5.7438 6.9462 5.3238 3.6639
T-47D GDSC2 5.8234 15.1969 -1.4835 13.7943
SK-BR-3 CTRP2 5.9246 7.4714 5.2288 3.667
T-47D CTRP2 6.0472 10.3644 3.8867 9.058
BT-20 GDSC2 6.5088 17.113 -1.9433 14.4355
AU565 CTRP2 6.8179 16.2741 1.5589 16.69
MDA-MB-415 CTRP2 6.9947 10.5522 4.525 4.7685
BT 239 CTRP2 0.5043 12.7508 -2.5834 42.3655
BT 428 CTRP2 1.0286 8.6686 -0.3173 37.0581
BT 416 CTRP2 1.783 8.0043 0.7426 31.7532
BT 286 CTRP2 2.7352 12.2557 -0.118 31.2106
BT 440 CTRP2 2.7639 5.9699 2.4844 22.8276
BT 504 CTRP2 3.0005 8.5851 1.7998 24.5944
BT 271 CTRP2 3.1113 10.437 1.0969 26.6636
BT 231 CTRP2 3.4727 12.7908 0.3453 27.9637
BT 228 CTRP2 3.5835 5.8505 3.4091 17
BT 131 CTRP2 3.7528 11.7863 1.0951 24.9545
BT 139 CTRP2 3.8271 9.8754 2.0693 21.3717
BT 482 CTRP2 4.5863 6.3839 4.349 10.5616
BT 159 CTRP2 4.6696 7.817 3.855 12.2524
BT147 CTRP2 4.8182 15.7974 0.1118 25.3633
BT 172 CTRP2 5.0948 13.8121 1.3433 20.92
BT 216 CTRP2 5.1401 8.2215 4.1337 9.9655
BT 444 CTRP2 5.1791 7.5808 4.4739 8.4865
BT 328 CTRP2 5.3355 9.4195 3.7349 11.1627
BT 187 CTRP2 5.461 14.4205 1.3608 20.0642
BT 330 CTRP2 5.639 17.3273 0.0617 23.7351
BT 232 CTRP2 5.7063 7.2777 5.1275 4.5604
BT 422 CTRP2 5.7448 11.5758 3.0252 13.212
BT 333 CTRP2 5.8147 11.0586 3.3434 11.7719
BT 340 CTRP2 5.8293 16.036 0.8683 20.9209
BT 320 CTRP2 5.9416 6.6863 5.6342 1.9334
BT 248 CTRP2 6.0045 19.1972 -0.5652 24.6835
BT 359 CTRP2 6.6269 13.5114 2.7845 12.4752
BT 498 CTRP2 7.149 8.5927 5.5305 0.7473
BT 245 CTRP2 7.3007 18.072 1.0429 17.5581
⏷ Show the Full List of 89 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA CTRP2 -6.0792 214.2885 -108.3456 51.1505
KS-1 [Human Krukenberg tumour] GDSC1 -1.9341 9.069 -5.6809 44.9612
ONS-76 GDSC1 -0.6426 8.218 -4.0552 36.7736
GI-1 GDSC1 0.8614 1.9402 0.4099 5.1813
GB-1 GDSC1 0.8783 5.2851 -1.2448 17.661
Hs 683 GDSC2 0.9542 8.0203 -1.7343 27.8021
KG-1-C CTRP2 0.9763 19.1914 -5.1159 43.1552
SF126 GDSC1; GDSC2 1.0529 7.6613 -1.4672 26.3239
SF268 GDSC1 1.5168 7.9305 -2.0445 20.2828
SF539 CTRP2 1.6788 6.8797 1.0284 31.2245
D-245MG GDSC2 1.8329 11.1094 -2.4857 27.6238
D-423MG GDSC2 2.0169 10.8003 -2.1741 25.9369
U-87MG ATCC GDSC1 2.1546 4.1638 0.2452 2.8472
D-336MG GDSC1; GDSC2 2.3727 6.7528 0.1487 13.482
CAS-1 GDSC1 2.3963 4.1468 0.3816 1.5917
D-502MG GDSC1; GDSC2 2.501 5.1148 1.0718 7.407
D-247MG GDSC1; GDSC2 2.652 11.6855 -2.0878 23.7328
AM-38 GDSC1 2.8714 4.8147 0.3352 1.2578
D-542MG GDSC2 2.9116 7.437 0.2377 11.4558
8-MG-BA GDSC1 2.914 10.6286 -2.3274 17.5368
D-263MG GDSC1 2.9488 4.3315 0.5498 0.3476
D283 Med GDSC1 2.9514 4.4423 0.5108 0.4651
SF539 GDSC1 3.0334 7.4106 -0.7109 7.5018
Becker GDSC1 3.3731 4.9279 0.4972 0.3039
KINGS-1 GDSC1 3.375 15.1034 -4.1836 24.1142
Onda 10 GDSC1; GDSC2 3.6536 9.4756 -0.215 12.2086
NMC-G1 GDSC1; GDSC2 3.6572 11.6925 -1.3024 17.7128
YKG-1 GDSC2 3.7791 9.7761 -0.2716 12.2243
D-566MG GDSC2 3.8132 7.9659 0.625 7.059
LN-229 CTRP1 3.8714 10.7614 1.1662 33.8114
SF268 CTRP2 4.0876 10.9691 1.8078 21.6624
SF295 GDSC2; CTRP1 4.2528 12.1063 0.8428 21.865
SNB-75 CTRP2 4.2904 10.9692 2.0018 20.4542
Onda 11 GDSC1; GDSC2 4.3558 8.3037 0.808 5.016
SNB-75 GDSC1; GDSC2 4.5861 8.7408 0.7454 4.9776
KALS-1 GDSC1 4.6338 20.4623 -5.894 26.2042
U-251MG CTRP2 4.7384 6.3398 4.5287 9.4492
GaMG CTRP1 4.7832 10.5931 2.0588 25.3428
KNS-42 GDSC1; GDSC2 5.0668 12.2949 -0.6045 11.2172
KNS-81-FD GDSC1; GDSC2 6.8246 16.7377 -1.5685 12.4103
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -0.3328 5.5293 -2.4529 29.8427
TGBC24TKB GDSC1 -0.3184 4.8283 -2.0995 28.0366
TGBC1TKB GDSC1 1.5457 6.6107 -1.3645 16.0645
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP1 -3.9579 4.9133 -4.742 78.5181
RL95-2 GDSC1 -1.177 7.3332 -4.1239 39.3311
MFE-296 CTRP2 3.0827 10.9887 0.8149 27.6288
MFE-319 CTRP1 3.803 12.2078 0.3905 36.5901
HEC-151 CTRP1 4.4719 13.7506 0.2147 34.2066
HEC-6 CTRP1 4.4954 14.128 0.0467 34.581
HEC-1-A CTRP2 4.7226 9.6424 3.0525 15.3503
KLE GDSC1; CTRP1 4.8103 12.1412 1.3084 19.4366
HEC-265 CTRP1 4.9729 14.9891 0.0219 32.8363
HEC-59 CTRP1 5.6182 13.9973 1.0468 26.8807
HEC-251 CTRP1 6.4557 15.6557 0.8747 24.7577
HEC-108 CTRP1 9.5902 26.6032 -2.2104 26.4771
Ishikawa (Heraklio) 02 ER- CTRP1 0.6657 14.6807 -3.7696 53.4094
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB65-RCC GDSC1; GDSC2 1.1534 7.9398 -1.5118 26.1523
LB1047-RCC GDSC1; GDSC2 1.5363 7.14 -0.7695 21.2938
TK-10 GDSC1 1.6776 9.5864 -2.7424 23.2841
A-704 GDSC1 1.7695 4.6974 -0.2533 7.3981
NCC010 GDSC2 1.7724 9.2446 -1.6074 24.4466
KTCTL-140 GDSC2 2.5483 12.4707 -2.5651 25.7781
OS-RC-2 GDSC1 2.6154 12.377 -3.4048 23.2733
A-498 GDSC1 2.7024 4.0268 0.5646 0.4344
LB2241-RCC GDSC1; GDSC2 3.1668 5.586 1.329 4.2125
KTCTL-26A GDSC2 3.2058 7.0546 0.6456 8.2673
KTCTL-13 GDSC2 3.6919 8.4589 0.3066 9.1677
SW156 GDSC2 3.7609 7.6928 0.7202 6.6105
UO-31 GDSC2 3.8143 6.1335 1.4691 2.3058
LB996-RCC GDSC1 3.8374 13.1336 -2.896 17.9112
UO-31 CTRP2 3.9161 28.5928 -7.0491 38.6513
NCC021 GDSC2 4.1592 9.5267 0.1117 9.2727
VMRC-RCW GDSC2; CTRP1 4.23 6.2335 3.6911 8.956
KTCTL-21 GDSC2 4.2949 12.4056 -1.1852 15.6525
HA7-RCC GDSC1; GDSC2 4.5413 16.5114 -3.0188 22.3358
Caki-1 GDSC2 4.6981 11.5097 -0.4745 11.2963
KTCTL-1M GDSC2 4.8465 8.3283 1.0701 2.9367
RCC10RGB GDSC1; CTRP1 5.5354 6.9914 4.4551 2.1809
RXF 393L GDSC1; GDSC2 5.6694 14.2594 -1.1408 12.6066
TUHR14TKB CTRP2 5.818 9.9034 3.9231 19.421
RCC10RGB CTRP2 7.0443 10.457 4.6056 4.3681
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW948 CTRP1 -5.1912 7.8202 -6.9869 75.2263
SNU-175 CTRP1 -4.3026 5.2367 -5.2067 78.4051
CL-34 CTRP1 -4.1281 12.3149 -7.5795 67.852
NCI-H508 GDSC2; CTRP1 -3.3011 7.0656 -4.682 59.1926
SW48 CTRP1 -3.2054 -0.5706 -3.2079 94.895
COLO205 CTRP1 -2.6668 7.2907 -4.0723 70.9152
GP2d CTRP1 -2.3087 8.2831 -4.0456 68.3591
KM12 GDSC1; CTRP1 -1.8549 4.307 -2.2951 55.7852
SK-CO-1 CTRP1 -0.4398 12.5854 -3.8946 58.121
LS411N GDSC1; CTRP1 0.3654 11.7015 -2.6823 44.1985
LS513 GDSC1; CTRP1 1.278 5.4135 0.8307 33.1272
NCI-H747 GDSC1 1.4616 9.0809 -2.6625 23.6341
LS1034 GDSC1 2.364 11.7747 -3.2971 23.5606
COLO 320HSR GDSC1 2.3933 6.3345 -0.6146 8.3648
SNU-C1 GDSC1 2.3979 5.1551 -0.0605 4.4437
CL-11 GDSC1 2.5513 6.4403 -0.5615 7.5999
HCT 116 CTRP1 2.6755 12.7107 -0.8982 44.1953
SW620 GDSC2; CTRP1 2.7435 8.0787 1.356 24.1967
SNU-C4 CTRP1 2.7685 34.2833 -11.5033 47.9032
LoVo CTRP1 2.8651 7.5159 1.7302 37.549
SNU-283 GDSC2 2.8923 9.5014 -0.8043 17.3006
LS180 CTRP1 2.9499 9.7694 0.7773 39.9732
SNU-1040 CTRP1 3.0205 5.2482 2.7799 30.8318
T84 CTRP2 3.0219 7.9022 2.1023 23.4475
NCI-H747 CTRP2 3.2357 8.6018 2.0376 23.0776
SNU-C5 CTRP1 3.5849 8.0833 2.1931 30.7524
SNU-C2A CTRP1 3.5879 8.1633 2.1582 30.9228
RKO GDSC1; CTRP1 3.6218 5.8348 3.2269 13.7139
DLD-1 CTRP1 3.7375 9.5331 1.6435 32.585
HT115 GDSC2; CTRP1 3.8033 12.1443 0.4222 24.6343
NCI-H716 GDSC1 3.9063 5.9205 0.3455 0.4712
HT-55 CTRP1 4.0088 5.2565 3.8534 16.1862
RCM-1 [Human ESC] CTRP1 4.177 6.7124 3.4175 18.8183
HT-29 GDSC2; CTRP1 4.4767 7.6084 3.2715 10.2995
SNU-81 GDSC2; CTRP1 4.659 6.4833 3.9911 6.2925
COLO 320 CTRP2 4.7514 10.6628 2.5855 17.1345
SW403 CTRP1 4.8234 10.5357 2.1218 24.8065
COLO 320 CTRP1 4.9043 8.1984 3.3586 15.7558
SNU-61 CTRP1 4.9046 7.6882 3.6136 13.5986
C2BBe1 GDSC1; CTRP1 4.9208 6.9703 3.9858 5.9551
CL-40 CTRP1 4.9964 7.0823 3.9947 9.8449
CW-2 GDSC1; CTRP1 5.1024 6.6821 4.2832 3.9553
HCT 8 CTRP1 5.1292 8.6227 3.3352 14.983
HCT 8 CTRP2 5.1666 6.7192 4.8445 7.0418
COLO 678 CTRP1 5.5213 7.8662 4.0195 7.6057
SW480 CTRP1 5.9865 9.7978 3.411 11.1704
LS123 GDSC1; CTRP1 6.158 14.6319 1.1546 16.8967
SNU-C4 CTRP2 6.4112 8.2409 5.2348 2.757
SNU-C2B GDSC1 7.4312 23.7082 -5.5461 20.113
MDST8 GDSC1; CTRP1 8.2873 19.8307 0.1598 16.5255
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.3289 5.1911 0.3858 0.6578
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 -0.0525 3.8346 -0.7962 27.7068
SNU-398 CTRP1 4.0135 12.2524 0.5577 35.1563
Hep-G2 CTRP1 4.4044 5.3967 4.2306 10.7096
JHH-6 CTRP1 5.3521 6.4542 4.5879 3.1742
SNU-449 CTRP1 6.1103 9.691 3.5497 9.6516
Cancer Drug Sensitivity Data Curated from 174 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-LCD CTRP1 -6.8873 3.6259 -7.6169 84.6086
COR-L279 CTRP1 -4.0317 17.1789 -9.5975 63.9457
NCI-H847 GDSC1 -3.8477 -2.5793 -3.8479 60.5668
NCI-H810 CTRP1 -3.8298 9.7539 -6.2322 70.0631
LCLC-97TM1 CTRP1 -3.813 14.2973 -8.0972 65.5298
LB647-SCLC GDSC1; GDSC2 -3.5021 0.4682 -3.6406 57.4066
NCI-H2227 GDSC2 -3.0547 3.3359 -3.851 52.7446
LC-2/ad GDSC1; GDSC2 -2.8577 1.0693 -3.0447 51.7485
NCI-H524 GDSC1 -2.0918 1.4435 -2.505 40.4653
NCI-H510A GDSC1; GDSC2 -1.9398 2.3482 -2.3362 43.83
HARA [Human squamous cell lung carcinoma] CTRP1 -1.8427 12.8847 -5.4553 62.1626
NCI-H211 GDSC1 -1.6393 2.921 -2.5632 37.5131
IST-SL1 GDSC1; GDSC2 -1.2985 4.3519 -2.3228 39.878
SCLC-21H CTRP1 -1.2944 7.3941 -2.628 66.3615
Lu-99 CTRP1 -1.2293 8.4648 -2.9616 64.6024
NCI-H596 CTRP1 -0.9603 9.6338 -3.1473 62.2723
NCI-H1048 CTRP1 -0.8829 11.4783 -3.8534 60.365
NCI-H1568 CTRP1 -0.6553 9.3223 -2.6986 61.4236
NCI-H1963 GDSC1; CTRP1 -0.4769 7.0235 -1.6136 47.1043
HOP-62 GDSC1 -0.3515 7.6951 -3.5312 34.0486
NCI-H187 GDSC1 -0.3472 3.5864 -1.5358 24.9417
NCI-H82 GDSC1; CTRP1 -0.3257 5.7544 -1.0212 45.7468
EBC-1 CTRP1 -0.3142 6.8792 -1.3863 62.8129
LXF 289 GDSC1; CTRP1 -0.1919 10.1172 -2.5503 46.3467
NCI-H1930 CTRP1 -0.1559 17.3565 -5.8368 55.2737
COR-L321 GDSC2 -0.0792 4.2737 -1.0043 28.8426
NCI-H1876 GDSC1; CTRP1 -0.044 8.6189 -1.7673 45.0665
NCI-H841 CTRP1 0.0362 33.7046 -13.6386 52.4716
DMS 273 CTRP1 0.0585 39.7182 -16.5961 52.0701
A-427 GDSC2 0.2165 4.3658 -0.7358 26.2098
SBC-1 GDSC1; GDSC2 0.2391 5.7458 -1.3312 28.9346
NCI-H2009 CTRP1 0.2785 11.2978 -2.5879 56.1052
RERF-LC-MS GDSC2 0.2786 8.0381 -2.3773 32.705
NCI-H2171 GDSC1; GDSC2 0.3086 4.1588 -0.5518 24.8587
Lu-134-A GDSC1; GDSC2 0.3409 4.8182 -0.807 26.0376
NCI-H1792 CTRP1 0.3653 12.8852 -3.2244 55.0603
NCI-H720 GDSC1 0.4784 11.0249 -4.4535 33.4722
NCI-H1304 GDSC1 0.6132 6.1052 -1.8817 22.7161
NCI-H209 GDSC1 0.8539 8.6825 -2.9637 27.1321
NCI-H647 GDSC2 0.8801 7.0801 -1.3445 26.4281
NCI-H1944 CTRP1 0.9515 7.7636 -0.3704 54.4241
HCC15 CTRP1 0.9817 4.8463 0.6656 56.2384
NCI-H1648 GDSC1 1.0178 19.9661 -8.4683 38.7494
NCI-H1770 GDSC1; GDSC2 1.0657 3.2848 0.6059 15.1721
EPLC-272H CTRP1 1.1128 18.324 -5.0936 51.3995
COR-L32 GDSC2 1.1667 5.7982 -0.4529 20.9219
Lu-139 GDSC1 1.2659 7.7167 -2.1394 21.6793
NCI-H358 CTRP1 1.295 11.6175 -1.7144 51.341
HCC33 GDSC1; GDSC2; CTRP1 1.3048 8.4621 -0.2902 35.0006
NCI-H1436 GDSC1; GDSC2 1.4405 6.7199 -0.6488 20.9952
A-549 CTRP1 1.4606 9.2581 -0.4754 50.6393
NCI-H23 GDSC1; CTRP1 1.6911 4.5761 1.5032 28.72
NCI-H2073 CTRP1 1.7395 8.108 0.3121 48.6082
NCI-H1651 CTRP2 1.9403 20.7946 -4.9789 40.7783
NCI-H2081 GDSC1; GDSC2; CTRP1 1.9731 8.6831 0.3026 30.7479
NCI-H1666 GDSC1; CTRP1 1.9765 5.702 1.4997 27.6065
NCI-H526 GDSC1 2.0041 7.0454 -1.2322 13.7238
NCI-H226 GDSC1 2.0829 4.1103 0.2277 3.1074
NCI-H292 GDSC2 2.1285 7.4807 -0.4204 17.4948
NCI-H2126 CTRP1 2.1366 9.8424 -0.0572 46.1979
DMS 114 CTRP2 2.1726 13.4436 -1.2274 35.2732
NCI-H1581 GDSC1 2.1783 7.1595 -1.1615 12.7342
HCC44 CTRP1 2.1968 5.5584 1.786 42.5997
NCI-H2122 CTRP1 2.236 10.8913 -0.4485 45.9728
NCI-H1092 GDSC1 2.2518 9.1344 -2.0769 18.1023
NCI-H1155 GDSC1 2.2522 6.4127 -0.7472 9.6729
NCI-H1105 GDSC2; CTRP1 2.3577 14.2655 -1.9521 35.2605
Lu-165 GDSC1 2.3731 4.1771 0.3572 1.7664
NCI-H1694 CTRP2 2.4153 11.9584 -0.2969 32.5674
NCI-H1437 GDSC2; CTRP1 2.4417 10.5232 -0.074 30.36
IA-LM GDSC1 2.5036 10.3067 -2.4675 19.4049
DMS 454 CTRP2 2.5358 17.0223 -2.5862 36.5967
EKVX CTRP2 2.551 8.7002 1.2815 27.6761
NCI-H838 GDSC2 2.5878 7.5524 -0.0752 14.1783
NCI-H146 GDSC2 2.5892 12.0083 -2.3004 24.7155
NCI-H727 CTRP1 2.6031 6.7157 1.7967 39.1949
ABC-1 GDSC2 2.7187 13.4162 -2.8981 26.4198
HCC78 CTRP1 2.7479 11.1817 -0.0914 42.7968
Lu-65 GDSC1; CTRP1 2.7528 6.1981 2.1599 21.7868
NCI-H1650 GDSC1 2.7708 4.6498 0.3549 1.2695
NCI-H69 GDSC1 2.7873 9.5902 -1.9121 15.6392
DMS 114 GDSC1 2.7909 5.8493 -0.1449 4.2284
COR-L95 GDSC1 2.8194 4.4067 0.4707 0.6998
NCI-H2286 CTRP1 2.8591 10.646 0.2719 41.5805
PC-14 GDSC2 2.8941 8.9188 -0.5127 15.7678
NCI-H64 GDSC1 2.8983 4.2741 0.5511 0.3686
LC-1/sq-SF CTRP1 2.9093 8.0348 1.5435 37.9446
NCI-H2291 GDSC2 2.9555 7.6612 0.1602 11.8002
DMS 79 GDSC1; GDSC2 2.968 8.4058 -0.1997 13.8447
NCI-H446 GDSC1 3.0005 14.1659 -3.9992 24.4401
NCI-H250 GDSC2 3.0433 11.1449 -1.5037 20.2192
NCI-H128 GDSC1 3.0958 5.0707 0.3344 1.0412
SK-LU-1 CTRP1 3.1077 7.2235 2.1074 34.213
NCI-H2196 GDSC1; GDSC2 3.1201 6.0375 1.08 5.8197
HCC1833 CTRP1 3.1207 6.8957 2.2631 33.3141
NCI-H2869 GDSC2 3.1673 5.7971 1.2284 4.8158
NCI-H1299 CTRP1 3.1952 18.6666 -3.3544 44.3303
CPC-N GDSC1 3.2056 10.5678 -2.0939 15.5288
NCI-H1975 GDSC1; CTRP1 3.2501 9.2306 1.3242 23.8522
DMS 53 CTRP2 3.253 9.2063 1.7934 23.9083
NCI-H345 GDSC1; GDSC2 3.3154 8.9706 -0.2152 13.0332
NCI-H2444 GDSC2 3.318 7.7359 0.3935 9.5142
LCLC-103H CTRP1 3.3193 5.8989 2.8794 28.0951
NCI-H2803 GDSC2 3.3515 11.4124 -1.3964 18.9195
NCI-H748 GDSC1; GDSC2 3.3533 14.8898 -3.1245 25.4809
NCI-H522 CTRP1 3.3968 14.6928 -1.2048 41.4721
Ms-1 GDSC1 3.412 5.2899 0.3825 0.6172
HCC2108 CTRP1 3.5199 8.99 1.6992 33.557
NCI-H740 GDSC2 3.552 7.5468 0.6499 7.4605
COR-L51 CTRP1 3.567 12.4194 0.0717 38.4669
NCI-H1563 CTRP2 3.6109 6.2046 3.3432 17.1542
HCC366 GDSC2 3.6237 11.5787 -1.2714 17.653
COR-L88 GDSC1; CTRP1 3.6608 9.8361 1.4243 22.1462
NCI-H2135 GDSC1; GDSC2 3.7096 6.7174 1.1449 4.2493
NCI-H2810 GDSC2 3.7253 6.2995 1.3452 3.1006
NCI-H2804 GDSC2 3.735 16.4673 -3.6104 26.0101
SHP-77 GDSC1; CTRP1 3.75 5.9636 3.3114 12.8687
HOP-62 CTRP2 3.8032 13.7934 0.1737 27.5988
NCI-H322M GDSC1 3.847 6.1579 0.2365 0.8489
T3M-10 CTRP1 3.9042 5.7472 3.5614 19.1812
COR-L303 GDSC2 3.9477 12.8525 -1.6575 18.5802
NCI-H290 GDSC2 4.0784 13.1253 -1.695 18.4289
NCI-H1755 CTRP1 4.0924 5.2336 3.9518 14.8788
HCC1359 CTRP1 4.1058 5.3752 3.918 15.0656
CAL-12T GDSC2; CTRP1 4.1271 15.0161 -0.7161 27.414
NCI-H1373 CTRP1 4.1617 11.5044 1.061 32.799
NCI-H1869 GDSC1 4.163 12.8424 -2.5381 15.4703
NCI-H3255 GDSC2; CTRP1 4.177 11.4222 1.1154 20.9862
NCI-H1836 GDSC1; GDSC2; CTRP1 4.1776 10.1301 1.756 18.2634
Calu-6 GDSC1; CTRP1 4.1835 12.4132 0.629 23.8401
NCI-H1573 CTRP1 4.2175 9.6462 2.0312 28.1783
COLO 699 CTRP1 4.2986 7.6957 3.0634 21.0145
NCI-H1838 GDSC1 4.3242 5.8013 0.5316 0.0596
NCI-H2141 GDSC1; CTRP1 4.3641 8.0482 2.952 12.7986
NCI-H2405 CTRP1 4.4171 9.9889 2.0405 27.1447
NCI-H661 CTRP1 4.4505 11.3256 1.4051 30.0888
NCI-H2029 GDSC2; CTRP1 4.4957 9.0316 2.5857 13.5876
EMC-BAC-1 GDSC2 4.4979 12.6364 -1.1537 15.0511
NCI-H1793 CTRP1 4.5718 9.1658 2.5867 23.0862
COLO 668 GDSC1; CTRP1 4.6622 7.8803 3.3053 10.1702
HCC1438 CTRP2 4.7364 13.4709 1.1917 22.2408
NCI-H460 GDSC2; CTRP1 4.8031 10.0204 2.3618 13.8931
HCC827 CTRP1 4.8638 8.2979 3.2741 16.6279
Sq-1 CTRP1 4.869 6.8022 4.0244 10.1357
ChaGo-K-1 GDSC2; CTRP1 4.8822 14.9329 -0.0261 23.4069
NCI-H1734 GDSC2 4.9171 6.8302 1.6966 0.4327
HOP-92 CTRP2 4.9192 9.562 3.2781 28.2404
NCI-H2030 GDSC2; CTRP1 4.9616 6.7462 4.1328 4.8269
NCI-H1781 CTRP1 4.9635 6.7615 4.1269 8.8012
RERF-LC-KJ CTRP1 5.0049 6.0645 4.5104 5.1711
HCC4006 CTRP1 5.0365 10.9485 2.0954 24.0313
COR-L23 CTRP1 5.0434 7.241 3.9549 10.0019
NCI-H2172 GDSC2; CTRP1 5.0934 6.7557 4.2391 3.9942
NCI-H1694 GDSC1; CTRP1 5.116 9.6204 2.8256 11.5022
BEN GDSC2; CTRP1 5.1203 14.042 0.6184 20.5671
NCI-H2342 CTRP1 5.2558 8.3669 3.566 12.5375
NCI-H1435 CTRP1 5.2684 8.2419 3.6384 11.8677
NCI-H1355 GDSC1; CTRP1 5.2732 16.9956 -0.7319 25.5615
HCC1195 CTRP1 5.3677 6.5303 4.5619 3.3509
HCC2935 CTRP1 5.406 6.9465 4.3864 4.7666
HCC2935 CTRP2 5.4157 7.5097 4.7391 6.8341
NCI-H2023 CTRP1 5.4749 7.4599 4.185 6.3094
KNS-62 CTRP1 5.6867 15.1318 0.5356 28.6246
IST-SL2 GDSC1; GDSC2 5.6936 15.6273 -1.774 15.2987
EKVX GDSC1; GDSC2 5.7441 8.1536 1.5379 0.4752
NCI-H2110 GDSC2; CTRP1 6.0222 20.3176 -1.7833 25.9374
DV-90 CTRP1 6.19 7.8541 4.4533 2.1914
NCI-H1915 CTRP1 6.352 13.1352 2.0412 19.3857
NCI-H441 CTRP1 6.5561 11.2659 3.0971 11.7858
KNS-62 CTRP2 6.9815 10.3761 4.6011 4.4788
NCI-H1793 CTRP2 7.2033 17.9748 1.0154 17.8203
Calu-3 CTRP1 7.5667 18.734 0.182 24.2004
Calu-1 CTRP2 7.8203 18.201 1.3752 15.5652
NCI-H650 CTRP1 8.464 17.0662 1.6004 15.7845
⏷ Show the Full List of 174 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 2.9009 7.1463 -0.6704 7.5282
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 -1.0766 8.219 -2.4133 48.1842
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 0.1148 8.7687 -1.3317 42.2684
Caov-3 GDSC2; CTRP1 -4.7487 9.4816 -7.1099 62.1389
OVKATE CTRP1 0.2909 4.4792 0.0015 62.9051
Kuramochi GDSC1 0.5641 8.8264 -3.2822 29.4825
COV434 CTRP2 1.3189 11.8652 -1.3596 38.0853
OVCAR-4 GDSC1; CTRP1 1.7576 18.9387 -4.7933 41.7577
ES-2 GDSC1 2.0637 5.891 -0.6258 9.3244
OVCAR-8 CTRP1 2.4444 18.2791 -3.8392 46.9906
A2780 CTRP1 2.7076 10.3891 0.2482 42.4624
COV434 CTRP1 3.1434 7.1732 2.1661 33.6754
JHOS-2 GDSC2 3.2063 8.957 -0.2905 13.7284
HEY A8 CTRP1 3.3076 12.7668 -0.3368 40.4797
RMUG-S CTRP1 3.4121 7.6795 2.2103 31.708
OVCAR-5 CTRP2 3.9135 7.234 3.3126 16.3935
JHOM-1 CTRP1 4.0967 6.1647 3.5865 17.8554
RMG-I CTRP1 4.1825 8.6996 2.4649 25.8222
SNU-840 CTRP1 4.2971 8.5029 2.6671 23.9017
OV-90 CTRP1 4.4475 10.3991 1.8636 27.9387
IGROV-1 CTRP1 4.8372 8.1361 3.3319 16.275
COV362 CTRP1 4.8627 7.4709 3.6857 13.1585
OC 314 CTRP2 4.9301 10.1483 3.0031 15.065
OV7 CTRP1 4.9677 7.6085 3.7073 12.5105
COV644 CTRP1 5.1274 7.4607 3.9146 10.0146
SK-OV-3 CTRP1 5.1788 7.6291 3.8723 10.1816
JHOC-5 CTRP1 5.2442 16.9287 -0.7223 33.8524
TYK-nu CTRP1 5.3742 14.8417 0.4277 30.1061
COV318 CTRP1 5.5826 11.0591 2.4833 19.4358
EFO-21 CTRP1 5.6378 8.7889 3.6516 10.376
JHOS-4 GDSC2; CTRP1 5.6494 12.4426 1.8469 14.3296
OAW42 CTRP1 5.7856 7.1426 4.5422 2.3711
EFO-27 GDSC2; CTRP1 6.0462 9.6515 3.5243 5.6404
OVK18 GDSC2; CTRP1 6.1672 19.4653 -1.2428 24.2317
OVMANA CTRP1 7.4982 14.5264 2.1712 15.1649
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 4.0723 11.1923 1.6863 22.1347
Yamato-SS CTRP2 4.3146 8.4834 3.1956 15.782
MFH-ino GDSC1 -6.864 -4.2154 -6.8676 88.704
SK-UT-1 GDSC1 -2.7355 2.258 -3.4782 47.6653
VA-ES-BJ GDSC1 -2.1692 2.6477 -3.0156 42.5426
SW982 GDSC1 -2.0368 8.7483 -5.6252 45.3613
TTC-709 CTRP2 -0.4245 8.8312 -1.9331 45.0986
G-401 CTRP1 -0.0832 6.865 -1.1323 61.6046
SK-LMS-1 GDSC1 0.2455 4.6686 -1.4956 21.9176
EW-8 GDSC1 1.0545 5.0721 -0.9908 15.2268
SW872 GDSC1 1.2563 4.3208 -0.452 10.5096
STS-0421 GDSC2 1.9882 10.1247 -1.8609 24.81
SW684 GDSC1 2.2437 3.5276 0.5612 0.8215
A-204 CTRP2 2.5441 9.3205 1.013 28.5603
TE 441.T GDSC1; GDSC2 2.6067 8.843 -0.7044 17.5899
BT-16 CTRP2 2.7575 7.5908 1.9419 24.7939
Tm87-16 CTRP2 2.8685 4.8839 2.8128 21.3467
SW982 CTRP2 3.6183 5.5442 3.5146 16.5189
KYM-1 CTRP2 3.7734 11.9725 1.0258 25.1253
GCT CTRP2 4.3596 12.116 1.5112 22.0434
BT-12 CTRP2 5.0819 6.6152 4.7973 7.4561
RKN CTRP1 6.4611 15.591 0.9109 24.591
HT-1080 CTRP1 6.6494 18.2508 -0.263 28.2416
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC1; GDSC2 -2.8921 -1.2649 -2.8934 52.3174
TE-15 GDSC1 -0.4272 4.7878 -2.1838 29.0013
TE-10 GDSC1; GDSC2 0.0811 3.4817 -0.5154 25.6611
TE-8 GDSC1 0.6539 13.9709 -5.776 35.8364
TE-9 GDSC1 1.5557 8.1342 -2.1152 20.5399
TE-1 GDSC1 2.3246 12.6904 -3.7814 25.5245
TE-6 GDSC1 2.3754 5.1986 -0.0939 4.7242
KYSE-510 GDSC2 3.084 4.8293 1.6321 2.5853
EC-GI-10 GDSC1 3.2504 9.1077 -1.3668 11.2114
KYSE-410 CTRP1 3.8998 10.7293 1.2079 33.5127
TE-5 GDSC1 3.9662 13.1533 -2.8177 17.2467
KYSE-150 CTRP2 4.4469 8.2354 3.4412 14.4698
KYSE-140 CTRP1 4.7458 22.3638 -3.8559 40.3389
TE-14 CTRP2 4.7925 8.5498 3.6402 12.8101
KYSE-30 CTRP2 5.1991 13.515 1.5832 19.8595
KYSE-450 CTRP1 5.6065 15.338 0.3682 29.4891
KYSE-510 CTRP2 6.2215 13.7529 2.3368 14.9757
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -1.7264 12.4253 -7.1182 45.2236
HuP-T4 CTRP1 0.4563 10.2421 -1.9372 55.8623
QGP-1 GDSC2; CTRP1 3.0337 13.1567 -0.7808 30.5739
Panc 10.05 CTRP1 3.4008 10.9757 0.626 37.9065
HPAC CTRP1 3.6167 7.5775 2.4609 29.0042
Panc 08.13 CTRP2 3.7927 10.9385 1.5372 23.3672
Hs 766T CTRP2 3.7934 6.3886 3.4859 16.0871
Panc 10.05 CTRP2 3.9107 10.6762 1.7761 22.2231
MZ-PC-1 GDSC1; GDSC2 3.9535 11.2456 -0.8641 14.8983
Capan-2 CTRP1 4.0227 9.6419 1.8554 30.0823
KP-3 CTRP1 4.0321 8.3545 2.4929 26.4409
SUIT-2 CTRP1 4.1314 7.1391 3.1719 21.0489
Panc 03.27 CTRP1 4.3944 29.8725 -7.906 43.9616
Capan-2 CTRP2 4.7651 11.4151 2.2304 18.47
CFPAC-1 CTRP1 6.2606 14.1938 1.4502 22.8148
PaTu 8902 CTRP1 6.6268 15.3665 1.1463 23.0457
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; CTRP1 0.5288 3.4282 0.4462 37.8778
MPP 89 GDSC1 1.7561 5.6017 -0.7052 10.7986
NCI-H28 CTRP1 3.6406 8.8235 1.8947 31.9651
NCI-H2052 CTRP1 4.3309 9.9514 1.9823 27.8773
IST-Mes1 GDSC1 5.1828 16.3665 -3.5395 17.6254
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 2.3948 7.4406 -1.1449 12.0071
LNCaP clone FGC GDSC1 3.9698 6.1059 0.3035 0.5595
NCI-H660 GDSC2 4.0725 5.4442 1.8706 0.3684
PaCa-3 CTRP1 5.7271 16.8568 -0.2928 31.1479
NCI-H660 CTRP2 6.0675 8.6671 4.7522 5.3869
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 2.7719 7.9052 -1.111 10.7767
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-388 GDSC1; GDSC2 -1.3636 3.5096 -2.0773 39.578
A-431 GDSC2 -0.5207 8.4866 -3.3616 38.5339
HT-144 GDSC1 -0.3555 8.2377 -3.8025 34.8777
SH-4 GDSC1 0.551 12.6309 -5.1937 34.9859
A101D GDSC1 0.636 8.9728 -3.2936 29.2543
CP67-MEL GDSC1 1.0425 3.4936 -0.2115 9.3918
A-375 GDSC2; CTRP1 1.0727 6.6423 0.1928 34.5142
CP50-MEL-B GDSC2 1.3309 7.0309 -0.9021 22.6833
SK-MEL-30 GDSC2 1.5407 10.8913 -2.63 29.0307
DJM-1 GDSC1; GDSC2 2.2515 9.7759 -1.4639 22.3152
COLO 783 GDSC2 2.3375 5.7827 0.6045 10.8018
G-mel GDSC2 2.3378 7.2158 -0.1118 15.116
COLO 800 GDSC1; GDSC2 2.4745 4.8626 1.1764 6.8205
GAK GDSC1 2.4853 4.1956 0.4047 1.3461
SK-MEL-3 GDSC2 2.6382 8.3704 -0.4429 16.1037
SK-MEL-2 GDSC1 2.7929 9.049 -1.646 14.0756
IPC-298 GDSC2 2.8134 11.593 -1.9107 22.5772
Hs 852.T CTRP1 3.0012 10.1048 0.6674 39.9465
UACC-257 GDSC1 3.0039 10.4854 -2.1942 16.597
Hs 940.T GDSC2 3.0777 5.1314 1.4861 3.4559
SK-MEL-31 GDSC2 3.1003 14.4975 -3.13 26.1423
CP66-MEL GDSC1; GDSC2 3.1708 4.8442 1.6783 2.1684
WT2-iPS GDSC2 3.2538 8.0569 0.1891 10.8748
COLO 829 GDSC1 3.4104 6.0647 0.0832 1.9223
IST-MEL1 GDSC1 3.4527 13.6643 -3.4227 21.111
Mel Ho GDSC2 3.4988 7.8634 0.4602 8.7009
MMAc-SF GDSC1; GDSC2 3.5587 11.9323 -1.4955 18.833
LB373-MEL-D GDSC1; GDSC2 3.5685 8.4891 0.2053 10.0321
MZ-MEL-7 GDSC1; GDSC2 3.7422 12.157 -1.4679 18.2519
Hs 938.T GDSC2 3.841 10.5323 -0.5964 13.8055
MZ-MEL-2 GDSC1; GDSC2 3.9016 16.6749 -3.5843 25.5441
Malme-3M CTRP2 4.2264 8.9767 2.8817 17.2445
SK-MEL-5 GDSC2; CTRP1 4.2684 5.0146 4.2079 6.4721
Hs 940.T CTRP2 4.2687 6.1083 4.0887 12.4615
SK-MEL-1 GDSC1; CTRP1 4.3262 11.3481 1.2846 20.8263
VMRC-MELG GDSC2 4.3792 5.6871 1.9 0.1856
RVH-421 GDSC2 4.4663 6.3761 1.6833 0.7102
451Lu GDSC2 4.4668 14.3993 -2.0359 18.9347
Hs 944.T CTRP1 4.5072 9.6754 2.2762 25.3613
LOX-IMVI GDSC1 4.6042 13.9264 -2.7629 15.5465
Hs 688(A).T CTRP2 4.6353 6.1274 4.4832 9.9225
COLO 741 CTRP1 4.6885 13.0843 0.7335 31.6773
Hs 934.T CTRP2 4.7088 16.0128 -0.0924 26.1724
IGR-37 CTRP2 5.1065 6.359 4.9204 6.9186
Hs 936.T CTRP1 5.2424 17.4976 -1.0082 34.5186
G-361 CTRP1 5.67 19.3242 -1.5711 34.407
LB2518-MEL GDSC1; GDSC2 5.7656 15.003 -1.4295 13.7046
SK-MEL-28 GDSC2; CTRP1 6.2876 11.9108 2.5952 9.617
EquiPSC Line K2 GDSC2 3.7771 18.8372 -4.7566 28.8565
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -4.2856 0.9162 -4.5597 62.5705
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 CTRP2 -0.8298 6.2164 -1.5053 46.5387
HSC-39 GDSC1 0.4179 6.8642 -2.4303 26.4232
AGS CTRP1 0.6434 6.8113 -0.3308 57.1946
SNU-16 GDSC1 0.9031 5.0739 -1.1183 16.6939
RF-48 GDSC1 0.9821 6.3584 -1.6941 20.1627
SNU-216 CTRP2 2.0572 10.584 -0.0381 33.0063
SNU-5 GDSC1 2.3794 5.0735 -0.0343 4.3019
GCIY GDSC1 2.585 10.6713 -2.5867 19.7574
SCH GDSC1; GDSC2 2.8256 4.4769 1.6298 3.1163
ECC12 GDSC2 2.8396 7.5975 0.1022 12.4482
SNU-1 GDSC1 3.1873 7.017 -0.4404 5.4017
TMK-1 GDSC2 3.9272 11.5425 -1.0285 15.7645
NUGC-4 CTRP1 4.1209 11.6011 0.9766 33.2946
KE-39 CTRP2 4.6954 12.1863 1.7876 20.2695
Fu97 CTRP1 4.7995 11.1344 1.8023 26.6475
SNU-601 CTRP2 5.0769 7.582 4.3718 9.1518
MKN7 GDSC2; CTRP1 5.861 8.3206 4.0384 3.505
SH-10-TC CTRP1 6.5663 10.9851 3.2383 10.7029
MKN74 CTRP1 6.5772 12.7842 2.3768 16.6352
SNG-M CTRP1 7.1224 15.3203 1.5297 19.7166
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1 0.7023 6.145 -1.8247 22.0274
KMH-2 GDSC2 1.7573 6.5314 -0.27 17.8436
ML-1 [Human leukemia] GDSC2 2.7752 4.9094 1.3837 4.7451
CGTH-W-1 GDSC1 2.8881 4.6166 0.4198 0.8538
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1; GDSC2 -1.9077 1.9905 -2.2079 43.3261
PCI-06A GDSC2 -1.8813 1.3153 -2.0347 42.6943
JHU-011 GDSC2 0.3543 8.1971 -2.382 32.4224
HSC-2 CTRP1 1.259 12.6709 -2.2421 51.3897
CAL-33 CTRP2 1.3332 9.1657 -0.1907 35.7155
KOSC-2 GDSC2 1.9746 10.4063 -2.0132 25.4547
PCI-15A GDSC2 3.1673 9.5449 -0.6115 15.5613
LB771-HNC GDSC1 3.2347 5.2502 0.3249 0.9617
OSC-19 GDSC2 3.3206 8.6226 -0.0398 12.0322
SCC-15 GDSC1 3.3483 5.4611 0.2926 1.0021
BB49-HNC GDSC1 3.4746 5.5183 0.3233 0.7856
PCI-04B GDSC2 3.5792 11.2256 -1.1305 17.103
JHU-029 GDSC2 3.5979 8.0293 0.4489 8.5457
BICR 31 GDSC2 3.8248 6.3093 1.3976 2.6647
PE/CA-PJ15 GDSC2 3.8369 6.5591 1.293 3.2073
SCC-9 CTRP1 4.2946 6.8543 3.4654 17.7953
BICR 16 CTRP2 4.6381 8.6645 3.4347 14.0171
BHY GDSC2 4.7499 6.8067 1.6387 0.6772
SCC-25 GDSC2 4.8193 7.0911 1.5601 0.8877
KON GDSC2 4.8931 21.7108 -5.322 27.7729
BICR 56 CTRP2 5.2492 17.9625 -0.5896 26.289
SCC-4 CTRP2 5.7647 9.1151 4.2702 8.0148
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP1 -6.6731 4.1169 -7.5002 83.483
RT-4 CTRP1 0.5756 6.6914 -0.3599 57.7688
U-BLC1 CTRP2 3.2108 13.6689 -0.3269 30.4381
HT-1376 CTRP1 3.4441 9.6947 1.2881 35.6157
KMBC-2 CTRP1 5.2502 9.9575 2.7672 18.8281
UM-UC-3 CTRP1 5.2696 11.8158 1.8544 24.3968
T24 GDSC2 5.2802 8.0849 1.3758 1.2029
KMBC-2 CTRP2 6.1057 17.0155 0.6099 21.1723
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -5.5118 -2.119 -5.5566 75.4427
SW954 GDSC1; GDSC2 -2.6158 0.3593 -2.6847 49.573
KGN GDSC1 -0.4806 9.6941 -4.6352 37.4437
JEG-3 GDSC2 1.708 15.4045 -4.7377 33.9177
NEC8 GDSC1 1.9558 4.6964 -0.1251 5.9384
LB831-BLC GDSC1 2.297 6.4224 -0.7213 9.3692
ACC-OV7 GDSC2 2.5524 7.8777 -0.2664 15.3703
OVCA433 GDSC2 2.8191 9.1165 -0.6704 16.8115
NCC-IT GDSC1 2.9788 10.6081 -2.2715 17.0711
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 3.3798 5.2585 1.6134 2.1864
DSH1 GDSC1 3.5678 17.312 -5.1274 26.5368
UWB1.289 GDSC2 3.687 10.1123 -0.5025 13.6804
OV17R GDSC2 4.2903 8.6204 0.6228 6.155
JAR GDSC1; GDSC2 4.5618 6.3972 1.7148 0.555
SW962 GDSC1; GDSC2 4.7128 7.4044 1.3888 1.6322
JHOS-3 GDSC2 4.8074 6.693 1.7037 0.4629
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5718).
2 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
3 Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth. Clin Cancer Res. 2008 Sep 1;14(17):5437-46. doi: 10.1158/1078-0432.CCR-07-4922.
4 Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Clin Cancer Res. 2008 Oct 1;14(19):6106-15. doi: 10.1158/1078-0432.CCR-08-0721.