Details of the Drug

General Information of Drug (ID: DM9QU5Y)

Drug Name
GSK343
Synonyms compound 6 [PMID 24900432]; GSK 343
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 541.7
Logarithm of the Partition Coefficient (xlogp) 4
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C31H39N7O2
IUPAC Name
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide
Canonical SMILES
CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
InChI
InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChIKey
ULNXAWLQFZMIHX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
71268957
CAS Number
1346704-33-3
TTD ID
D02TVQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Enhancer of zeste homolog 1 (EZH1) TTNJA0C EZH1_HUMAN Inhibitor [1]
Enhancer of zeste homolog 2 (EZH2) TT9MZCQ EZH2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Gene/Protein Processing [2]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.1802 5.1378 2.2933 5.2026
EW-12 GDSC2 2.1048 4.0122 -0.6393 0.7389
EW-13 GDSC2 2.1309 4.1186 -0.669 0.8226
U-CH2 GDSC2 2.252 4.2862 -0.6815 0.7819
ES5 GDSC2 2.7428 5.6169 -0.9847 1.5202
CHSA0011 GDSC2 2.9274 5.5393 -0.8736 0.9753
CHSA0108 GDSC2 3.1275 5.091 -0.6328 0.2669
CAL-78 GDSC2 3.2017 4.4012 2.6791 3.3253
EW-7 GDSC2 3.4839 5.8844 2.1731 5.1123
ES6 GDSC2 3.4861 6.1631 2.0357 5.7589
ES1 GDSC2 3.5505 5.2425 2.5449 4.2941
SK-ES-1 GDSC2 3.6733 7.5021 1.5169 7.8299
SJSA-1 GDSC2 3.7162 5.9947 2.2982 5.4216
CAL-72 GDSC2 3.7351 7.8296 1.4024 8.2438
CHSA8926 GDSC2 3.7875 10.3222 0.2018 13.6128
NOS-1 [Human HNSCC] GDSC2 3.7987 6.2282 2.2445 4.1659
HOS GDSC2 3.8503 5.3646 2.7003 1.9791
HuO9 GDSC2 3.9906 6.6289 2.1871 4.0936
HuO-3N1 GDSC2 4.1311 6.7894 2.2074 3.7665
ES7 GDSC2 4.208 7.2248 2.0505 4.3569
SK-PN-DW GDSC2 4.2302 7.1791 2.0878 4.1507
CADO-ES1 GDSC2 4.3816 6.3633 2.5672 1.8271
A-673 GDSC2 4.5556 6.0591 2.7934 0.7857
SaOS-2 GDSC2 4.5781 6.9879 2.3998 2.2799
ES8 GDSC2 4.6406 7.3893 2.2538 2.8152
EW-3 GDSC2 4.6875 7.3499 2.3001 2.5594
EW-24 GDSC2 4.8858 6.2217 2.8777 0.3368
MHH-ES-1 GDSC2 5.0489 7.2442 2.5444 1.2291
TC-71 GDSC2 5.066 6.5812 2.817 0.3981
EW-16 GDSC2 5.2342 11.1026 0.8867 7.9308
EW-1 GDSC2 5.2598 8.6703 2.0379 2.9463
G-292 clone A141B1 GDSC2 5.3046 11.5533 0.7184 8.5504
EW-11 GDSC2 5.3852 8.076 2.3645 1.5682
MG-63 GDSC2 5.4121 6.976 2.8099 0.2769
NY GDSC2 5.7599 8.6499 2.311 1.4408
ES4 GDSC2 5.7853 8.083 2.5487 0.713
U2OS GDSC2 5.9202 8.3153 2.5172 0.7238
EW-18 GDSC2 6.0139 7.8681 2.7198 0.2563
EW-22 GDSC2 6.088 7.9043 2.7345 0.2153
H-EMC-SS GDSC2 6.8613 9.0494 2.6175 0.2113
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 2.0809 9.2532 -3.0282 13.0935
RPMI-8402 GDSC2 0.0143 2.5456 -0.1093 33.7932
SU-DHL-16 GDSC2 0.3858 2.2647 -0.8291 4.2283
SUP-B8 GDSC2 0.5939 4.0882 -1.5727 8.338
OCI-Ly7 GDSC2 0.6499 3.1176 -1.056 5.0155
QIMR-WIL GDSC2 0.7299 8.892 -3.8533 20.3181
Jiyoye GDSC2 0.8076 5.5412 -2.1297 11.1655
NK-92MI GDSC2 0.8553 3.3706 -1.0368 4.4537
NB4 GDSC2 1.0119 6.6082 -2.5034 12.7992
BC-3 GDSC2 1.0138 3.0305 -0.7769 2.6358
BONNA-12 GDSC2 1.0613 3.8876 -1.1465 4.6886
MC116 GDSC2 1.0822 12.8056 -5.5248 25.5982
HEL GDSC2 1.4502 3.6428 -0.802 2.1037
MOLM-16 GDSC2 1.4534 3.3021 -0.6548 1.3811
RL GDSC2 1.5362 4.3666 -1.0749 3.4241
SKM-1 GDSC2 1.546 2.8232 -0.4229 0.3944
KMS-11 GDSC2 1.5508 3.9974 -0.9022 2.4788
DoHH2 GDSC2 1.566 3.0023 -0.4822 0.572
SIG-M5 GDSC2 1.5809 2.8214 -0.4082 0.3344
HT GDSC2 1.5891 14.0771 -5.762 25.097
SR GDSC2 1.6363 3.5928 1.4019 13.6263
JeKo-1 GDSC2 1.6519 11.6464 -4.5104 20.6807
TALL-1 [Human adult T-ALL] GDSC2 1.7269 3.9135 -0.7739 1.6221
SU-DHL-4 GDSC2 1.7306 3.1584 -0.4727 0.4394
OCI-Ly19 GDSC2 1.771 3.7412 -0.6817 1.1691
SU-DHL-10 GDSC2 1.821 3.2775 1.6958 11.7895
LP-1 GDSC2 1.828 3.4129 -0.528 0.5526
CTB-1 GDSC2 1.9255 4.1115 -0.759 1.3464
Farage GDSC2 2.039 3.4224 -0.4486 0.2431
RCH-ACV GDSC2 2.0642 5.606 -1.327 3.9571
MHH-CALL-4 GDSC2 2.077 4.3191 -0.7719 1.2571
Kasumi-1 GDSC2 2.129 10.7089 -3.7006 16.1861
THP-1 GDSC2 2.1707 5.7738 -1.3415 3.8731
MY-M12 GDSC2 2.2382 8.5525 -2.5856 10.4825
SU-DHL-1 GDSC2 2.2518 14.4327 -5.4365 22.5766
CRO-AP2 GDSC2 2.2624 3.9435 -0.5499 0.389
WSU-DLCL2 GDSC2 2.3299 3.3512 2.2311 10.4772
NU-DUL-1 GDSC2 2.3416 3.8406 -0.4838 0.2178
A3/Kawakami GDSC2 2.3916 3.3491 2.2991 7.3681
SU-DHL-5 GDSC2 2.3935 3.0514 2.3677 7.0866
DEL GDSC2 2.5028 3.3577 2.418 6.5013
BL-41 GDSC2 2.5064 3.0814 2.4841 6.2235
SU-DHL-6 GDSC2 2.5186 4.3486 2.0467 8.07
GR-ST GDSC2 2.5385 3.9922 2.2226 7.2259
Karpas-45 GDSC2 2.5666 3.3567 2.4878 5.9973
MV4-11 GDSC2 2.6218 3.4787 2.5099 7.6272
VAL GDSC2 2.6247 7.7545 0.5008 14.9183
ATN-1 GDSC2 2.6951 3.9167 2.4174 5.8919
WSU-NHL GDSC2 2.7185 4.0032 2.404 5.8823
Karpas-422 GDSC2 2.734 5.9935 1.4693 10.1671
AMO1 GDSC2 2.7395 3.5317 2.6188 4.8754
SUP-M2 GDSC2 2.7513 3.6073 2.6032 4.9045
JSC-1 GDSC2 2.853 5.4824 1.8297 8.1788
HAL-01 GDSC2 2.9048 6.1984 1.5228 9.4963
Karpas-299 GDSC2 2.9088 3.8273 2.6762 4.1047
ALL-SIL GDSC2 2.9092 4.3563 2.4305 5.2282
JJN-3 GDSC2 2.9586 4.134 2.5841 4.3854
SCC-3 GDSC2 3.0103 3.9102 2.7401 3.5272
IM-9 GDSC2 3.1559 4.2626 2.707 3.3036
EoL-1 GDSC2 3.1653 5.5068 2.0964 6.1704
JVM-2 GDSC2 3.1687 6.3715 1.6676 8.1948
MOLT-16 GDSC2 3.1756 4.3326 2.69 3.3356
ARH-77 GDSC2 3.2165 4.5367 2.6246 3.5488
MHH-PREB-1 GDSC2 3.2227 4.5871 2.6049 3.6274
JVM-3 GDSC2 3.2398 5.5631 2.1321 5.8314
MEG-01 GDSC2 3.2429 6.3141 1.7595 7.5924
HDLM-2 GDSC2 3.2485 6.9311 1.4558 9.0182
ROS-50 GDSC2 3.2511 5.1421 -0.6063 0.1953
DB GDSC2 3.2523 5.3802 2.2342 5.3187
ST486 GDSC2 3.2709 5.6964 2.0919 5.9531
DG-75 GDSC2 3.278 5.3589 2.2666 5.1079
PL-21 GDSC2 3.2843 5.5467 -0.7347 0.417
DND-41 GDSC2 3.31 4.6921 2.6268 3.3269
BV-173 GDSC2 3.3194 4.7095 2.626 4.4135
RPMI-6666 GDSC2 3.3363 6.2434 1.8731 6.8479
K-562 GDSC2 3.3843 5.4761 2.2964 4.7357
MOLP-8 GDSC2 3.3884 4.7382 2.6684 2.9614
Daudi GDSC2 3.3888 5.3892 2.3435 4.5026
BE-13 GDSC2 3.3944 4.9952 2.5449 3.5346
BC-1 GDSC2 3.4074 4.9023 2.6017 3.2381
CML-T1 GDSC2 3.41 5.2579 2.4263 4.0648
MOLM-13 GDSC2 3.4105 5.0382 2.5365 3.5409
NKM-1 GDSC2 3.4451 6.8719 1.6485 10.2183
VL51 GDSC2 3.4453 5.6026 2.2827 4.6723
RPMI-8226 GDSC2 3.4489 5.9046 2.1348 5.366
P32/ISH GDSC2 3.4578 4.6432 2.7708 2.3354
MOLT-13 GDSC2 3.4923 5.3433 2.4495 3.7861
MN-60 GDSC2 3.5165 5.1338 2.5726 3.1556
RPMI-8866 GDSC2 3.5538 6.1093 2.1165 5.2381
LAMA-84 GDSC2 3.5768 7.011 1.6853 7.2315
Raji GDSC2 3.5832 5.317 2.5329 3.2142
LC4-1 GDSC2 3.5985 5.4899 2.4589 3.5331
Jurkat GDSC2 3.6029 5.0276 2.6904 2.4393
MLMA GDSC2 3.6096 6.6639 1.8842 6.2246
JURL-MK1 GDSC2 3.6363 6.1771 2.1472 4.9294
TUR GDSC2 3.6464 5.5128 2.4837 3.3262
L-540 GDSC2 3.6552 6.1683 2.166 4.8037
KMS-12-BM GDSC2 3.6639 6.2701 2.1222 4.9933
PF-382 GDSC2 3.6734 5.5004 2.5099 3.1539
EJM GDSC2 3.6951 5.4779 2.5369 2.9885
P12-Ichikawa GDSC2 3.7244 5.4649 2.5645 2.8081
OCI-M1 GDSC2 3.7279 5.5461 2.5274 2.9745
L-428 GDSC2 3.7539 5.8166 2.4137 3.4572
MM1.S GDSC2 3.7559 6.1155 2.2683 4.133
Reh GDSC2 3.7629 5.4412 2.6035 2.5616
MHH-CALL-2 GDSC2 3.7669 5.7047 2.478 3.1351
697 GDSC2 3.7754 5.4491 2.6085 2.5176
CA46 GDSC2 3.7783 7.1098 1.7936 6.3196
GA-10 GDSC2 3.7851 5.6463 2.5195 2.9111
U-698-M GDSC2 3.7878 5.7007 2.4948 3.0207
KOPN-8 GDSC2 3.826 5.5972 2.572 2.6004
Mono-Mac-6 GDSC2 3.8385 6.6106 2.0857 6.4445
ME1 GDSC2 3.8412 6.2162 2.2814 3.9173
KE-37 GDSC2 3.853 6.558 2.1224 4.6374
Ku812 GDSC2 3.8623 6.1387 2.3345 3.6337
NALM-6 GDSC2 3.8685 7.4564 1.6907 6.6304
Loucy GDSC2 3.8724 6.5635 2.1339 4.5484
RC-K8 GDSC2 3.8897 5.4429 2.6891 1.9691
OCI-AML-2 GDSC2 3.9301 6.1054 2.3987 3.2222
WIL2 NS GDSC2 3.9546 5.9421 2.4943 2.7459
KM-H2 GDSC2 3.9667 5.7498 2.5942 2.2768
A4/Fukuda GDSC2 3.9899 5.6393 2.6614 1.9443
P31/FUJ GDSC2 3.9908 5.3737 2.7854 1.8745
EB2 GDSC2 4.0019 6.476 2.2694 3.6957
KCL-22 GDSC2 4.0029 5.7354 2.6245 2.0878
U266B1 GDSC2 4.0317 6.5022 2.2774 3.6093
HC-1 GDSC2 4.0829 8.6834 1.2459 8.2987
RS4;11 GDSC2 4.0852 6.0003 2.5529 2.2844
BALL-1 GDSC2 4.0987 6.9872 2.0894 4.3602
SUP-T1 GDSC2 4.1233 6.3791 2.3985 2.9143
CTV-1 GDSC2 4.1292 5.8737 2.6396 1.8451
GDM-1 GDSC2 4.1303 6.9667 2.1213 4.161
YT GDSC2 4.1326 7.0119 2.1011 5.6632
SUP-HD1 GDSC2 4.2157 6.9604 2.1829 3.7421
OPM-2 GDSC2 4.2414 6.3434 2.4914 2.3319
ALL-PO GDSC2 4.2583 6.6305 2.3677 2.8498
P30/OHK GDSC2 4.338 6.1829 2.6232 1.649
HL-60 GDSC2 4.3399 6.8448 2.3194 2.9448
L-1236 GDSC2 4.3417 7.5836 1.9694 4.5092
KY821 GDSC2 4.3582 6.5312 2.4766 2.2377
KG-1 GDSC2 4.4252 6.1703 2.6781 1.3305
CCRF-CEM GDSC2 4.4683 6.1613 2.7054 1.1811
NCI-H929 GDSC2 4.6501 6.3245 2.7298 0.9249
H9 GDSC2 4.6543 11.1695 0.4456 10.8525
OCI-AML-3 GDSC2 4.6616 12.646 -0.2761 13.8933
OCI-AML-5 GDSC2 4.667 5.9687 2.8815 0.4381
Karpas-231 GDSC2 4.8168 6.3238 2.8088 0.553
MOLT-4 GDSC2 4.8472 6.5022 2.7517 0.7028
Karpas-1106P GDSC2 4.8652 6.4788 2.7693 0.6376
NOMO-1 GDSC2 4.9104 7.4201 2.3962 1.9107
Hs 445 GDSC2 5.0161 6.9045 2.6683 0.8436
SUP-B15 GDSC2 5.0261 6.6985 2.7548 0.5802
SU-DHL-8 GDSC2 5.1357 6.7127 2.7963 0.4152
KMOE-2 GDSC2 5.237 7.0327 2.7171 0.5638
ML-2 GDSC2 5.4047 6.951 2.8161 0.2677
Ramos.2G6.4C10 GDSC2 5.4085 6.739 2.8926 0.1431
EM-2 GDSC2 5.414 7.3471 2.6722 0.5874
Granta-519 GDSC2 5.448 7.3373 2.6904 0.5241
L-363 GDSC2 5.4506 21.2331 -3.9274 24.074
TK [Human B-cell lymphoma] GDSC2 5.5068 7.0583 2.8167 0.2355
CESS GDSC2 5.509 7.1392 2.7884 0.2855
Karpas-620 GDSC2 5.6508 7.3008 2.7847 0.2487
SK-MM-2 GDSC2 5.7654 7.6238 2.7124 0.3447
HH [Human lymphoma] GDSC2 5.8181 7.9575 2.6102 0.5438
Namalwa GDSC2 6.2835 19.6359 -2.5179 18.8508
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC2 2.0085 14.2201 -5.5134 23.3666
TE-12 GDSC2 2.5243 5.5694 -1.0684 2.0838
KYSE-50 GDSC2 2.827 5.179 1.9544 7.6603
OACM5.1 C GDSC2 3.8315 6.3105 2.2281 4.1827
OACP4 C GDSC2 3.8316 6.9001 1.9378 5.5409
FLO-1 GDSC2 3.9321 6.5212 2.1979 4.1448
KYAE-1 GDSC2 3.9874 6.3905 2.3006 3.5767
ESO-51 GDSC2 4.9924 6.9261 2.6484 0.9247
KYSE-220 GDSC2 5.8664 16.3931 -1.2336 15.3744
ESO-26 GDSC2 6.3387 8.1835 2.7285 0.1715
SK-GT-4 GDSC2 8.7184 23.3053 -2.6096 15.4345
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.9943 9.3829 1.5462 5.3984
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-6 GDSC2 1.4302 3.2974 -0.6645 1.4534
MHH-NB-11 GDSC2 1.5501 3.2441 -0.5844 0.9722
SK-N-MC-IXC GDSC2 1.8033 3.1171 -0.4289 0.287
CHP-126 GDSC2 1.8833 3.6173 -0.5825 0.6967
SJNB-17 GDSC2 2.1131 5.3839 -1.2017 3.231
SJNB-5 GDSC2 2.1292 3.6713 -0.5032 0.3311
KP-N-RT-BM-1 GDSC2 2.6682 4.6532 -0.6494 0.4609
KP-N-YS GDSC2 2.7092 4.651 -0.6329 0.4042
LA-N-6 GDSC2 2.8371 4.5572 -0.553 0.2068
SJNB-14 GDSC2 3.3629 4.9385 2.5476 3.5887
NB69 GDSC2 3.4777 5.2106 2.5041 3.5568
IMR-5 GDSC2 3.4999 5.8475 2.2043 4.9316
GI-ME-N GDSC2 3.5428 6.0913 2.1167 5.259
SJNB-13 GDSC2 3.5752 6.2184 2.079 5.3725
Kelly GDSC2 3.7768 5.8108 2.4332 3.3259
SK-N-DZ GDSC2 3.9121 7.3544 1.7739 6.1584
GOTO GDSC2 4.1355 7.3794 1.9247 5.056
NB(TU)1 GDSC2 4.3248 7.2515 2.117 3.8689
SK-N-SH GDSC2 4.6248 6.9076 2.4632 2.6174
SiMa GDSC2 5.0197 7.6723 2.3456 1.9912
SJNB-10 GDSC2 5.0787 6.8479 2.7196 0.6478
NB1 GDSC2 5.0998 10.0346 1.3065 8.3021
NH-12 GDSC2 5.1358 8.4611 2.0603 3.0023
CHP-212 GDSC2 5.1706 12.0346 0.3935 10.1706
SJNB-12 GDSC2 5.2076 7.4757 2.5265 1.5458
SK-N-FI GDSC2 5.2343 6.7641 2.8174 0.4343
CHP-134 GDSC2 5.3892 6.927 2.8188 0.2678
SK-N-AS GDSC2 5.5212 7.0737 2.8166 0.2315
SK-N-BE(2)-M17 GDSC2 5.552 7.1446 2.803 0.246
KP-N-YN GDSC2 5.9474 9.5639 2.022 2.2875
TGW GDSC2 5.9728 7.6702 2.7741 0.185
SJNB-7 GDSC2 5.9762 7.3586 2.8812 0.0692
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 3.8446 6.0435 2.3683 3.508
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1569 GDSC2 1.7738 4.6818 -1.0802 3.0863
HCC1500 GDSC2 1.9113 12.2719 -4.625 20.5073
DU4475 GDSC2 2.0334 3.202 1.9466 10.0376
HCC2218 GDSC2 2.2695 4.653 -0.8169 1.2668
MDA-MB-330 GDSC2 2.7516 5.0685 -0.769 0.7511
HCC1395 GDSC2 2.9106 5.4107 1.9176 10.1617
Evsa-T GDSC2 3.1243 4.4522 2.5846 3.9573
COLO 824 GDSC2 3.1445 5.1425 2.2598 5.4442
HCC1806 GDSC2 3.1619 5.6474 2.0233 6.5248
YMB-1-E GDSC2 3.3322 5.5037 -0.7019 0.3348
HCC1599 GDSC2 3.5623 6.445 1.9559 5.9807
MDA-MB-415 GDSC2 3.651 5.5438 2.4719 3.3733
HCC1937 GDSC2 3.7065 5.954 2.311 4.0243
HCC70 GDSC2 3.7616 7.3894 1.642 7.0657
MDA-MB-453 GDSC2 3.7865 10.7983 -0.0365 14.6426
HCC1954 GDSC2 3.9513 5.759 2.5796 2.3659
BT-549 GDSC2 4.0361 7.0574 2.0108 4.8305
MFM-223 GDSC2 4.1073 6.2155 2.4657 2.6385
HCC1428 GDSC2 4.1574 6.1308 2.5377 2.2476
HCC1143 GDSC2 4.1824 7.2844 2.0039 4.6127
MDA-MB-231 GDSC2 4.2283 6.2096 2.5454 2.1166
HDQ-P1 GDSC2 4.2485 8.0801 1.6638 6.0646
Hs 578T GDSC2 4.3943 6.6413 2.448 2.3123
HCC38 GDSC2 4.5096 6.9486 2.3768 2.4639
CAL-120 GDSC2 4.5447 7.2352 2.2662 2.8904
MDA-MB-175-VII GDSC2 4.6834 10.3225 0.8812 11.6058
MDA-MB-157 GDSC2 4.6946 6.802 2.5489 1.5469
CAMA-1 GDSC2 4.7633 7.2427 2.3925 2.0885
MCF-7 GDSC2 4.9349 12.9613 -0.2285 13.1901
JIMT-1 GDSC2 4.9351 6.7813 2.68 0.8654
CAL-148 GDSC2 4.969 7.4113 2.4319 2.2836
HCC1187 GDSC2 4.9814 7.544 2.3808 1.8955
CAL-85-1 GDSC2 4.9987 7.8455 2.2574 2.3623
EFM-192A GDSC2 5.0242 6.8645 2.6882 0.776
MRK-nu-1 GDSC2 5.1546 6.4665 2.8943 0.2041
BT-474 GDSC2 5.1874 6.3616 2.9434 0.1207
T-47D GDSC2 5.2584 8.0583 2.3064 1.8974
ZR-75-30 GDSC2 5.26 7.022 2.7311 0.5157
AU565 GDSC2 5.2759 7.6828 2.4743 1.2802
MDA-MB-361 GDSC2 5.292 7.3691 2.6096 0.8345
BT-20 GDSC2 5.3497 7.2859 2.6681 0.633
UACC-812 GDSC2 5.3783 6.8513 2.8418 0.306
HCC1419 GDSC2 5.4122 10.9147 1.0942 6.7538
MDA-MB-468 GDSC2 5.4703 7.4073 2.6732 0.556
HCC2157 GDSC2 5.4964 6.8558 2.8839 0.1366
MDA-MB-436 GDSC2 5.5653 7.0525 2.8406 0.1819
BT-483 GDSC2 5.7299 14.3094 -0.3175 15.2978
OCUB-M GDSC2 5.7962 7.5089 2.7655 0.2404
EFM-19 GDSC2 5.8511 7.9244 2.6361 0.4707
CAL-51 GDSC2 6.0805 7.7841 2.7735 0.164
UACC-893 GDSC2 6.1756 8.7161 2.4725 0.7078
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KNS-81-FD GDSC2 1.0519 4.684 -1.5339 7.0252
YKG-1 GDSC2 1.174 2.8924 -0.6247 1.5791
D-423MG GDSC2 1.3762 3.7552 -0.8927 2.6867
KNS-42 GDSC2 1.5523 3.0716 -0.515 0.6987
D-542MG GDSC2 1.6449 3.3543 -0.5848 0.8897
NMC-G1 GDSC2 1.6565 3.3602 -0.582 0.8686
GI-1 GDSC2 1.8211 3.6443 -0.6201 0.8795
Onda 10 GDSC2 1.8831 3.6272 -0.5864 0.7104
Hs 683 GDSC2 1.9306 3.4751 -0.5094 0.4387
SF295 GDSC2 2.1743 3.9258 -0.5782 0.5066
D-247MG GDSC2 2.2497 4.271 -0.6767 0.7675
SF126 GDSC2 2.2642 3.6824 -0.457 0.1912
D-336MG GDSC2 2.2992 5.1382 -1.0002 2.0206
D-566MG GDSC2 2.4445 4.0786 -0.5293 0.2738
Onda 11 GDSC2 2.4516 4.4033 -0.6433 0.5469
8-MG-BA GDSC2 2.5978 4.698 1.9655 8.2157
D-502MG GDSC2 2.7018 4.9767 -0.7551 0.7375
SF539 GDSC2 2.8827 3.82 2.6527 4.2865
SNB-75 GDSC2 2.9435 4.7658 -0.5867 0.2359
D-245MG GDSC2 3.3056 6.1961 -0.9641 1.0283
42-MG-BA GDSC2 3.377 6.9472 1.555 8.2676
MOG-G-UVW GDSC2 3.5821 5.8275 2.2789 5.8849
DK-MG GDSC2 3.6984 5.2461 2.6527 2.4451
A-172 GDSC2 3.7318 5.9843 2.315 3.9586
D283 Med GDSC2 3.7913 6.3599 2.1742 4.5081
PFSK-1 GDSC2 3.7977 6.2885 2.214 4.3099
Daoy GDSC2 4.0467 5.9542 2.5497 2.3551
T98G GDSC2 4.0662 6.2906 2.4027 2.984
SW1783 GDSC2 4.1629 6.605 2.3173 4.2906
U-87MG ATCC GDSC2 4.5897 6.7842 2.4984 1.8614
YH-13 GDSC2 4.7351 7.5457 2.2392 2.7546
H4 GDSC2 4.8008 6.9971 2.5213 1.5436
KALS-1 GDSC2 4.8782 8.0993 2.072 3.277
KINGS-1 GDSC2 4.8807 7.4542 2.3647 2.0671
SW1088 GDSC2 4.9354 8.0448 2.1311 2.955
AM-38 GDSC2 5.0184 7.3203 2.4968 1.4247
CAS-1 GDSC2 5.0347 6.6178 2.7898 0.4812
U-118MG GDSC2 5.126 6.817 2.7524 0.5306
M059J GDSC2 5.142 8.0332 2.2544 2.216
MOG-G-CCM GDSC2 5.3029 7.69 2.4845 1.6319
GB-1 GDSC2 5.3963 6.7777 2.8747 0.1715
DBTRG-05MG GDSC2 5.4106 13.0795 0.0552 11.1879
Becker GDSC2 5.4375 6.9812 2.8179 0.2541
LN-405 GDSC2 5.5297 7.0642 2.8232 0.2182
D-263MG GDSC2 5.5927 7.5371 2.6752 0.493
LN-229 GDSC2 5.682 7.3079 2.7939 0.2248
U-251MG GDSC2 5.6966 7.3708 2.7771 0.2486
LN-18 GDSC2 5.7857 14.5983 -0.4184 12.4648
GaMG GDSC2 5.826 7.4367 2.8019 0.1783
SK-MG-1 GDSC2 5.8569 7.4602 2.8049 0.1676
ONS-76 GDSC2 6.0226 7.6398 2.8024 0.1395
KS-1 [Human Krukenberg tumour] GDSC2 6.2417 8.508 2.577 0.4448
SF268 GDSC2 6.3319 14.8945 -0.189 10.6931
D-392MG GDSC2 6.4805 8.8565 2.5436 0.4272
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 3.1114 4.7749 2.4133 4.7967
TGBC1TKB GDSC2 5.082 6.5222 2.8456 0.4339
TGBC24TKB GDSC2 5.2302 7.1457 2.6701 0.6968
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC2 4.2677 8.1401 1.6483 6.1027
ESS-1 GDSC2 4.9357 9.6138 1.3979 6.1439
MFE-319 GDSC2 5.0548 7.7689 2.3225 2.0438
EN GDSC2 5.2215 6.5433 2.8923 0.1886
RL95-2 GDSC2 5.2566 7.0487 2.7194 0.5475
MFE-280 GDSC2 5.9383 8.3487 2.5121 0.7274
MFE-296 GDSC2 6.0552 7.8334 2.7473 0.2045
AN3-CA GDSC2 6.072 7.928 2.7203 0.2405
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB65-RCC GDSC2 0.8817 6.6965 -2.6448 13.9135
NCC010 GDSC2 1.713 4.1875 -0.8974 2.2331
KTCTL-140 GDSC2 1.8118 4.0764 -0.7996 1.645
KTCTL-13 GDSC2 1.8152 4.0557 -0.7893 1.5942
LB2241-RCC GDSC2 1.8436 5.7632 -1.5286 5.4251
SW156 GDSC2 2.0769 3.9503 -0.6275 0.7178
NCC021 GDSC2 2.206 4.0965 -0.6289 0.6404
Caki-1 GDSC2 2.3428 11.4371 -3.9032 16.6058
VMRC-RCW GDSC2 2.3689 4.2003 -0.6017 0.4739
KTCTL-26A GDSC2 2.5133 4.3903 -0.6144 0.4407
HA7-RCC GDSC2 2.5679 4.6532 -0.689 0.616
UO-31 GDSC2 2.8263 4.7582 -0.6269 0.3476
RXF 393L GDSC2 2.9011 5.2798 -0.7869 0.7206
KTCTL-1M GDSC2 3.2205 5.7201 -0.8216 0.6538
KTCTL-21 GDSC2 3.272 13.3259 -4.1728 15.8083
CAL-54 GDSC2 3.3836 5.0073 2.5301 3.6279
LB1047-RCC GDSC2 3.4847 6.0091 -0.8237 0.5423
BFTC-909 GDSC2 3.5173 7.5665 1.3601 8.8891
769-P GDSC2 3.5941 7.2447 1.5825 7.6815
SW13 GDSC2 3.5959 5.1737 2.6133 2.8125
786-O GDSC2 3.6372 6.3257 2.074 5.2727
A-704 GDSC2 3.8202 5.7994 2.4699 3.0801
KTCTL-195 GDSC2 3.9569 6.1535 2.394 3.1989
KMRC-20 GDSC2 4.0088 6.8818 2.0768 4.5721
ACHN GDSC2 4.0507 5.8258 2.6127 2.0706
RCC10RGB GDSC2 4.6279 9.4491 1.2667 7.2314
TK-10 GDSC2 4.7889 7.135 2.4546 1.8131
SN12C GDSC2 5.3855 6.9998 2.7909 0.3236
OS-RC-2 GDSC2 5.5406 10.7785 1.2406 5.9365
LB996-RCC GDSC2 5.8327 7.9002 2.6376 0.475
VMRC-RCZ GDSC2 5.8898 7.5281 2.7933 0.1764
A-498 GDSC2 6.874 18.6997 -1.6458 15.1413
KMRC-1 GDSC2 8.9137 20.8741 -1.3475 13.6673
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H508 GDSC2 1.279 2.9506 -0.5951 1.3035
HT115 GDSC2 1.3678 3.414 -0.747 1.9362
SNU-61 GDSC2 1.4839 3.8352 -0.8677 2.3951
MDST8 GDSC2 1.5329 2.6805 -0.3757 0.2714
SNU-1040 GDSC2 1.549 2.7794 -0.4055 0.3428
LS513 GDSC2 1.7669 3.1813 -0.4666 0.4024
COLO 320HSR GDSC2 1.8789 3.2024 1.778 11.2561
SNU-283 GDSC2 1.9727 3.678 -0.5679 0.5903
SNU-81 GDSC2 2.2311 3.7221 -0.4829 0.2497
HCC2998 GDSC2 2.4838 3.4796 2.3598 6.8064
SNU-407 GDSC2 2.517 4.3892 -0.6126 0.4346
HT-29 GDSC2 3.0374 3.9609 2.7426 3.4413
RCM-1 [Human ESC] GDSC2 3.4272 4.7147 2.7112 2.6783
HCT 15 GDSC2 3.432 5.0144 2.5656 3.3586
CL-11 GDSC2 3.6436 9.7587 0.3675 13.1862
LoVo GDSC2 3.6729 6.4079 2.0608 5.2657
SK-CO-1 GDSC2 3.687 5.5192 2.5107 3.1255
HT-55 GDSC2 3.7907 5.6914 2.5015 2.9848
KM12 GDSC2 3.8126 10.8976 -0.0652 14.7094
HCT 116 GDSC2 3.9003 6.0174 2.4205 3.1719
LS411N GDSC2 4.1986 5.7556 2.7347 1.3589
NCI-H747 GDSC2 4.2601 8.7425 1.3482 7.4999
SNU-C1 GDSC2 4.3199 6.8877 2.2864 3.1194
C2BBe1 GDSC2 4.3437 6.7478 2.3672 2.73
LS1034 GDSC2 4.3523 6.6218 2.4312 2.4404
COLO205 GDSC2 4.4949 8.5688 1.6001 5.9392
LS123 GDSC2 4.5832 6.4849 2.6267 1.3636
RKO GDSC2 4.6451 9.0292 1.4816 6.2305
NCI-H716 GDSC2 4.6454 6.9833 2.4411 2.0286
CaR-1 GDSC2 4.6967 6.6773 2.604 1.3356
SW948 GDSC2 4.8247 6.8746 2.5864 1.2787
SW626 GDSC2 4.8367 7.0861 2.5019 1.5807
CW-2 GDSC2 4.8924 8.0524 2.102 3.1314
SNU-175 GDSC2 5.0824 7.3376 2.5221 1.278
GP5d GDSC2 5.122 6.7961 2.7587 0.5162
LS180 GDSC2 5.192 6.5988 2.8611 0.253
SW837 GDSC2 5.2158 7.1236 2.6724 0.699
SW48 GDSC2 5.3966 7.2615 2.6976 0.5315
SW1417 GDSC2 5.5539 7.1899 2.7875 0.2729
CCK-81 GDSC2 5.5632 7.6953 2.6023 0.6914
SNU-C5 GDSC2 5.6536 7.6102 2.6728 0.4716
COLO 678 GDSC2 5.6932 7.4771 2.7376 0.3208
SW1463 GDSC2 5.7569 7.7895 2.648 0.4836
SNU-C2B GDSC2 5.7916 8.8885 2.2278 1.6959
SW1116 GDSC2 5.8724 7.5651 2.774 0.2078
T84 GDSC2 6.0869 7.9379 2.7223 0.2337
SW620 GDSC2 6.1347 7.7513 2.804 0.1197
DiFi GDSC2 6.2467 9.2529 2.2952 1.1477
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 3.8466 5.7956 2.4904 2.9408
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 1.3478 8.4842 -3.1779 15.5397
JHH-1 GDSC2 3.5346 4.8158 2.744 2.3142
JHH-6 GDSC2 3.6218 6.4774 1.9866 5.716
Hep-G2/C3A GDSC2 3.7932 5.9235 2.3899 3.4977
HuH-1 GDSC2 3.9205 5.8475 2.5164 2.6999
SNU-449 GDSC2 3.9507 5.6832 2.6152 2.2069
SNU-423 GDSC2 3.9653 6.4799 2.2417 3.8849
JHH-2 GDSC2 4.158 6.8055 2.218 3.6747
JHH-4 GDSC2 4.7347 9.2252 1.4485 6.2347
SNU-398 GDSC2 4.9548 6.8159 2.6754 0.8658
JHH-7 GDSC2 4.9725 9.4126 1.5179 5.5559
Huh-7 GDSC2 5.0675 7.9377 2.2552 2.2941
SNU-387 GDSC2 5.0679 7.9779 2.2376 2.3633
SK-HEP-1 GDSC2 6.0173 7.386 2.886 0.0615
HLE GDSC2 6.5285 8.3761 2.7298 0.1382
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BEN GDSC2 0.5458 2.4614 -0.8108 3.7471
COR-L303 GDSC2 1.0972 3.6189 -0.9973 3.7455
HCC366 GDSC2 1.1167 8.8533 -3.5339 17.8443
NCI-H2171 GDSC2 1.1357 3.0121 -0.698 2.0113
NCI-H2444 GDSC2 1.2299 2.4838 -0.4277 0.6278
RERF-LC-MS GDSC2 1.2531 4.0999 -1.1235 4.187
NCI-H292 GDSC2 1.3903 4.9076 -1.4144 5.6145
A-427 GDSC2 1.4126 6.7452 -2.2802 10.5879
NCI-H460 GDSC2 1.415 2.7965 -0.4681 0.6321
NCI-H2081 GDSC2 1.4965 3.8809 -0.8809 2.4458
NCI-H2804 GDSC2 1.5075 4.2446 -1.0365 3.2605
NCI-H290 GDSC2 1.645 3.7638 -0.7522 1.6148
NCI-H1694 GDSC2 1.705 3.0267 -0.4344 0.3447
HCC33 GDSC2 1.7405 10.4998 -3.8794 17.8736
NCI-H2291 GDSC2 1.7585 3.5932 -0.6281 0.9624
COR-L321 GDSC2 1.7667 3.5134 -0.593 0.8208
NCI-H838 GDSC2 1.8261 3.3571 -0.5079 0.491
NCI-H2135 GDSC2 1.8633 3.2163 -0.4416 0.2928
NCI-H1105 GDSC2 1.9381 3.7262 -0.6008 0.7216
DMS 79 GDSC2 1.9482 3.7553 -0.6077 0.7384
NCI-H1770 GDSC2 1.9566 3.6145 -0.5507 0.5461
NCI-H2869 GDSC2 1.9584 4.6558 -0.9695 2.2745
NCI-H2803 GDSC2 1.9801 3.7396 -0.5882 0.6509
NCI-H510A GDSC2 2.0759 3.8073 -0.574 0.548
NCI-H1437 GDSC2 2.1299 3.8904 -0.583 0.5445
NCI-H1436 GDSC2 2.1351 3.7365 -0.5244 0.3807
NCI-H2172 GDSC2 2.1797 3.7033 -0.4955 0.2939
Calu-3 GDSC2 2.1841 3.9934 1.849 9.9518
NCI-H1963 GDSC2 2.189 4.0654 -0.6242 0.6361
NCI-H1836 GDSC2 2.1938 3.9283 -0.5713 0.4773
NCI-H2196 GDSC2 2.2182 3.7771 -0.5072 0.3058
NCI-H2810 GDSC2 2.2348 4.6648 -0.8375 1.3812
CAL-12T GDSC2 2.2886 15.7789 -6.0728 24.4361
NCI-H748 GDSC2 2.2908 4.2011 -0.6332 0.6043
LXF 289 GDSC2 2.2981 5.1793 1.4454 11.426
Lu-134-A GDSC2 2.3027 6.923 -1.7827 6.0273
SBC-1 GDSC2 2.3626 4.0772 -0.5596 0.3704
NCI-H146 GDSC2 2.3731 4.3518 -0.6559 0.6259
EKVX GDSC2 2.4436 5.0447 -0.8934 1.419
NCI-H2030 GDSC2 2.551 4.2109 -0.5364 0.2546
NCI-H2227 GDSC2 2.5609 4.1325 -0.5057 0.1973
NCI-H647 GDSC2 2.5985 4.7498 -0.7125 0.6682
LC-2/ad GDSC2 2.6029 4.608 -0.6585 0.5138
NCI-H3255 GDSC2 2.6095 4.9636 -0.7885 0.9022
IST-SL1 GDSC2 2.6914 4.5429 -0.6012 0.3398
NCI-H250 GDSC2 2.7587 4.3018 -0.4937 0.1374
NCI-H1734 GDSC2 2.8532 4.9756 -0.6944 0.4926
COR-L311 GDSC2 2.8677 4.1776 2.4747 5.137
LB647-SCLC GDSC2 2.909 4.9654 -0.6694 0.4105
NCI-H2110 GDSC2 2.9258 5.2804 -0.7772 0.6792
ChaGo-K-1 GDSC2 2.9468 4.9322 -0.6435 0.3413
EMC-BAC-1 GDSC2 2.952 5.7152 -0.9304 1.1521
ABC-1 GDSC2 2.9659 5.4999 -0.8426 0.852
LC-1/sq GDSC2 3.1088 6.2972 1.6531 8.4003
CPC-N GDSC2 3.1258 4.4419 2.5911 3.9228
SW1271 GDSC2 3.1933 4.6534 2.5462 3.9742
NCI-H740 GDSC2 3.2156 5.333 -0.685 0.3378
COR-L23 GDSC2 3.2345 6.7589 1.5301 8.6978
HCC827 GDSC2 3.2841 4.5033 2.6994 3.0396
NCI-H2023 GDSC2 3.2938 5.1834 2.3677 4.593
SK-MES-1 GDSC2 3.3759 5.213 2.421 4.162
HARA [Human squamous cell lung carcinoma] GDSC2 3.3819 5.0826 2.491 3.8168
Lu-135 GDSC2 3.4203 4.9224 2.6022 3.2093
NCI-H345 GDSC2 3.4761 5.32 2.4483 3.8243
Lu-139 GDSC2 3.5182 5.8623 2.2113 4.861
NCI-H69 GDSC2 3.5667 5.5452 2.4071 5.1186
NCI-H1648 GDSC2 3.5874 6.0749 2.1599 6.6196
PC-14 GDSC2 3.6083 6.4714 1.979 5.7791
NCI-H1693 GDSC2 3.6174 7.3282 1.5594 7.7427
SHP-77 GDSC2 3.6372 5.2031 2.6294 2.6616
Lu-65 GDSC2 3.6904 6.4184 2.0691 5.1925
NCI-H2087 GDSC2 3.7007 6.95 1.8131 6.3793
EPLC-272H GDSC2 3.7089 6.5542 2.0159 5.4074
NCI-H2795 GDSC2 3.728 5.9728 2.3178 3.9525
NCI-H446 GDSC2 3.7345 5.8995 2.3587 3.7491
LCLC-103H GDSC2 3.7761 5.6843 2.4945 3.0426
IST-SL2 GDSC2 3.7778 6.0282 2.3273 3.8171
NCI-H1792 GDSC2 3.8123 6.2738 2.2321 4.1991
NCI-H82 GDSC2 3.8177 5.8939 2.422 3.3057
NCI-H1876 GDSC2 3.8684 5.7047 2.5495 2.6339
LCLC-97TM1 GDSC2 3.9785 9.3893 0.8165 10.476
HCC78 GDSC2 3.9872 16.9237 -2.9328 24.3207
NCI-H1944 GDSC2 4.0044 7.8582 1.5944 6.8254
NCI-H2170 GDSC2 4.0065 5.8967 2.5506 2.4111
DMS 114 GDSC2 4.0278 5.8403 2.5912 2.1988
NCI-H720 GDSC2 4.0311 5.903 2.5638 2.3155
NCI-H1688 GDSC2 4.0314 7.3584 1.8601 7.3727
Calu-6 GDSC2 4.0838 6.0589 2.5244 2.4125
NCI-H2731 GDSC2 4.088 6.6397 2.2499 3.6426
NCI-H3122 GDSC2 4.1133 7.0008 2.093 4.3192
NCI-H1666 GDSC2 4.1184 6.6157 2.2822 3.4468
NCI-H1781 GDSC2 4.1229 15.0971 -1.9122 20.9869
COR-L279 GDSC2 4.1395 6.0841 2.5482 2.9693
RERF-LC-KJ GDSC2 4.1518 7.7217 1.7695 5.7453
NCI-H1703 GDSC2 4.1627 6.4022 2.4135 3.7171
SK-LU-1 GDSC2 4.1802 6.1976 2.521 2.2886
HCC44 GDSC2 4.2237 8.3652 1.5066 6.8338
NCI-H209 GDSC2 4.2311 8.3286 1.5299 6.7134
COR-L32 GDSC2 4.2991 6.3242 2.5359 2.0629
NCI-H1155 GDSC2 4.3446 7.1451 2.1807 3.5527
NCI-H1993 GDSC2 4.3464 6.3809 2.5384 1.9911
NCI-H211 GDSC2 4.3479 6.4655 2.5006 2.1493
NCI-H2066 GDSC2 4.354 8.4275 1.5698 8.3791
SBC-5 GDSC2 4.3576 5.8867 2.7651 1.0663
HOP-92 GDSC2 4.3756 9.5022 1.0599 8.6132
NCI-H226 GDSC2 4.3794 6.6516 2.4341 2.3913
NCI-H520 GDSC2 4.4004 6.6467 2.4492 2.2988
A-549 GDSC2 4.4101 6.9125 2.3322 2.7896
NCI-H1755 GDSC2 4.4659 8.2176 1.7494 5.3077
HCC15 GDSC2 4.4781 6.8654 2.3959 2.4236
SBC-3 GDSC2 4.4795 7.2694 2.2094 3.2277
NCI-H1651 GDSC2 4.503 7.2752 2.2215 3.1417
Lu-165 GDSC2 4.5348 8.377 1.7198 5.3313
NCI-H835 GDSC2 4.5479 8.676 1.5849 7.8546
PaCa-3 GDSC2 4.5542 6.8719 2.4384 2.8653
NCI-H1435 GDSC2 4.5676 6.7105 2.5186 1.8052
NCI-H2722 GDSC2 4.5971 7.234 2.2988 2.681
EBC-1 GDSC2 4.6012 10.7591 0.6081 10.2346
LOU-NH91 GDSC2 4.6455 6.824 2.5121 1.7434
NCI-H2009 GDSC2 4.655 7.0577 2.4133 2.8406
HOP-62 GDSC2 4.6767 7.9533 2.0144 3.8011
NCI-H358 GDSC2 4.6917 6.929 2.4915 1.7741
NCI-H847 GDSC2 4.6986 12.5676 -0.2098 17.1801
NCI-H1915 GDSC2 4.7647 6.4003 2.7542 0.7536
NCI-H1975 GDSC2 4.7902 7.428 2.3249 2.3311
NCI-H526 GDSC2 4.8501 6.5226 2.7448 0.722
COR-L88 GDSC2 4.8617 7.8375 2.1817 3.7788
NCI-H441 GDSC2 4.8903 7.5392 2.3324 2.1849
IA-LM GDSC2 4.904 6.7185 2.6909 0.8535
NCI-H2085 GDSC2 4.9069 7.8238 2.2145 2.6444
Lu-99A GDSC2 4.9493 7.8814 2.2131 2.599
VMRC-LCD GDSC2 4.9628 7.9127 2.2069 2.6087
NCI-H1838 GDSC2 4.9644 7.3627 2.4504 2.1964
EMC-BAC-2 GDSC2 4.9657 7.5109 2.3867 1.8889
NCI-H2461 GDSC2 4.9869 10.4739 1.0204 7.7405
UMC-11 GDSC2 5.06 6.8168 2.7235 0.6482
NCI-H196 GDSC2 5.0681 13.3627 -0.328 13.3508
NCI-H1563 GDSC2 5.0703 6.5601 2.8267 0.3732
NCI-H2369 GDSC2 5.1935 6.9612 2.7259 0.5643
RERF-LC-Sq1 GDSC2 5.1961 9.714 1.5202 5.2185
NCI-H1869 GDSC2 5.2124 8.1039 2.262 2.1122
NCI-H650 GDSC2 5.2231 7.9918 2.3163 1.8949
NCI-H64 GDSC2 5.239 6.4516 2.9309 0.1691
NCI-H2141 GDSC2 5.2443 6.7798 2.8156 0.3256
NCI-H2029 GDSC2 5.2473 6.9036 2.7706 0.4249
NCI-H1573 GDSC2 5.2491 7.257 2.6347 1.0505
Ms-1 GDSC2 5.2626 6.9645 2.7541 0.4574
NCI-H2122 GDSC2 5.2978 6.9419 2.7771 0.3879
NCI-H2818 GDSC2 5.3112 7.0287 2.75 0.4445
NCI-H23 GDSC2 5.3355 7.2398 2.6798 0.6095
NCI-H1341 GDSC2 5.3754 6.9617 2.8008 0.4097
LK-2 GDSC2 5.3906 7.0266 2.783 0.3378
NCI-H2405 GDSC2 5.4207 8.9762 1.993 2.9422
NCI-H1581 GDSC2 5.4216 6.8722 2.8507 0.2024
NCI-H1623 GDSC2 5.4422 11.1056 1.0235 7.0149
NCI-H1793 GDSC2 5.4595 16.6368 -1.6489 17.5299
NCI-H322M GDSC2 5.4805 8.587 2.1962 2.0916
NCI-H522 GDSC2 5.4834 10.4399 1.3625 5.4943
NCI-H513 GDSC2 5.4973 7.8598 2.5078 1.0051
NCI-H1568 GDSC2 5.4997 7.7215 2.564 0.8357
DMS 53 GDSC2 5.5054 7.7888 2.5399 0.9026
NCI-H810 GDSC2 5.5209 6.8323 2.9008 0.1114
NCI-H1092 GDSC2 5.5354 7.3479 2.7224 0.4104
DMS 273 GDSC2 5.6826 7.6493 2.67 0.4655
NCI-H524 GDSC2 5.7158 7.1763 2.8522 0.1347
NCI-H2342 GDSC2 5.7326 7.5447 2.7284 0.4335
NCI-H2228 GDSC2 5.7563 7.9502 2.5872 0.6292
NCI-H2373 GDSC2 5.7883 7.7321 2.6819 0.3977
COLO 668 GDSC2 5.8353 7.93 2.6276 0.4963
NCI-H1048 GDSC2 5.8511 7.3738 2.8326 0.1339
KNS-62 GDSC2 5.8845 11.4071 1.1629 5.7928
NCI-H841 GDSC2 5.8878 7.3825 2.8426 0.1165
COR-L105 GDSC2 5.9314 16.4894 -1.2342 15.2654
NCI-H1650 GDSC2 6.0254 7.7811 2.7546 0.2007
NCI-H661 GDSC2 6.0785 8.005 2.6955 0.2786
NCI-H1355 GDSC2 6.1715 8.0601 2.7107 0.2308
NCI-H2595 GDSC2 6.1845 7.959 2.7505 0.1731
NCI-H2347 GDSC2 6.2281 8.4078 2.6081 0.5181
NCI-H596 GDSC2 6.2658 7.7861 2.8375 0.0734
NCI-H727 GDSC2 6.3045 8.09 2.7484 0.1538
SW1573 GDSC2 6.4763 8.4794 2.6758 0.2124
NCI-H2591 GDSC2 6.6537 8.9565 2.5739 0.3217
NCI-H1299 GDSC2 8.4715 20.7963 -1.5871 12.6343
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 3.5126 5.6685 2.3035 4.4359
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-150 GDSC2 1.6165 4.7878 0.926 20.9421
TE-11 GDSC2 2.0171 3.7105 -0.5619 0.545
TE-10 GDSC2 2.3825 4.402 -0.6709 0.6659
T.T GDSC2 2.9305 4.4259 2.4174 6.9768
OE33 GDSC2 3.1223 5.7217 1.9519 6.9544
KYSE-140 GDSC2 3.3216 5.0765 2.4444 4.1677
KYSE-410 GDSC2 3.335 4.7941 2.5967 3.4153
OE19 GDSC2 3.443 5.2531 2.4553 3.8585
KYSE-520 GDSC2 3.5969 5.5211 2.4422 3.6148
KYSE-450 GDSC2 3.7942 5.3689 2.6603 2.2493
COLO 680N GDSC2 3.9612 6.9564 2.006 4.9847
TE-4 GDSC2 4.1588 6.1099 2.5484 2.1992
EC-GI-10 GDSC2 4.2644 11.8639 -0.1913 14.3153
TE-6 GDSC2 4.5795 6.3569 2.68 1.1671
OE21 GDSC2 4.898 6.8837 2.6197 1.096
TE-15 GDSC2 5.536 7.975 2.4795 1.0657
KYSE-270 GDSC2 5.5495 13.741 -0.1682 11.8664
TE-8 GDSC2 5.5742 8.2351 2.3917 1.3189
TE-5 GDSC2 5.6425 7.7086 2.6311 0.5759
TE-9 GDSC2 5.6456 7.1156 2.8479 0.1538
KYSE-510 GDSC2 5.941 22.0389 -6.5486 19.0956
KYSE-70 GDSC2 6.3847 8.3437 2.6897 0.2128
TE-1 GDSC2 6.427 8.0643 2.7997 0.0863
KYSE-180 GDSC2 8.0479 25.3713 -4.0558 20.219
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 GDSC2 1.0199 3.369 -0.9293 3.4953
JHOS-2 GDSC2 1.438 5.1123 -1.4801 5.9041
EFO-27 GDSC2 1.7675 6.1303 -1.747 6.8003
OVK18 GDSC2 1.9908 3.6645 -0.5554 0.5407
Caov-3 GDSC2 2.256 3.6389 -0.4449 0.1729
ES-2 GDSC2 3.2663 5.4244 2.224 5.3361
TYK-nu GDSC2 3.2752 4.5311 2.678 3.161
OV-90 GDSC2 3.3395 4.8677 2.5636 3.5627
OVISE GDSC2 3.6031 5.5704 2.4225 3.6957
OVKATE GDSC2 3.7507 6.0295 2.3067 5.2833
RMG-I GDSC2 3.8241 7.8297 1.4716 10.2754
OVCAR-3 GDSC2 3.9106 6.1025 2.3864 3.3111
A2780 GDSC2 4.1944 6.9537 2.1716 3.8271
TOV-21G GDSC2 4.2404 6.8964 2.23 3.491
OVCAR-8 GDSC2 4.4436 7.5218 2.0671 3.9105
OC 314 GDSC2 4.4689 7.8645 1.9208 6.0269
Caov-4 GDSC2 4.5126 6.9923 2.3586 3.3828
FU-OV-1 GDSC2 4.6672 7.0745 2.4128 2.8238
OAW42 GDSC2 4.7501 6.5777 2.6738 1.0342
OV56 GDSC2 4.8642 5.9863 2.9556 0.1831
OVTOKO GDSC2 5.3798 10.468 1.2837 5.9804
OVCAR-4 GDSC2 5.5019 7.729 2.562 0.84
DOV13 GDSC2 5.6026 7.0334 2.8608 0.1455
SK-OV-3 GDSC2 5.6747 7.5303 2.7109 0.3805
TOV-112D GDSC2 5.6759 7.541 2.7075 0.387
OVCAR-5 GDSC2 5.738 7.4969 2.7477 0.2875
EFO-21 GDSC2 6.1696 8.0382 2.7176 0.221
IGROV-1 GDSC2 6.2104 16.1538 -0.8755 13.5026
Kuramochi GDSC2 6.2415 9.1737 2.3241 1.0678
OAW28 GDSC2 6.8738 9.1059 2.6025 0.2282
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
QGP-1 GDSC2 1.7266 3.5112 -0.61 0.9189
DAN-G GDSC2 3.1444 4.417 2.6202 3.7406
Panc 10.05 GDSC2 3.4812 6.3163 1.9553 6.1502
CFPAC-1 GDSC2 3.5754 5.2045 2.5826 2.9954
MZ-PC-1 GDSC2 3.6277 5.9454 -0.748 0.3344
YAPC GDSC2 3.8564 6.3338 2.2349 4.1068
KP-1N GDSC2 3.8666 5.8966 2.4554 3.0678
Panc 02.03 GDSC2 3.9064 5.6913 2.5819 2.4255
BxPC-3 GDSC2 4.0316 5.8872 2.5716 2.2802
HuP-T3 GDSC2 4.1474 6.1487 2.523 2.3263
PSN1 GDSC2 4.3216 6.3055 2.558 1.9406
Capan-1 GDSC2 4.5606 6.6007 2.5635 1.6338
MIA PaCa-2 GDSC2 4.6036 9.5095 1.2203 7.4829
Panc 04.03 GDSC2 4.6107 7.8021 2.0433 5.0198
AsPC-1 GDSC2 4.8421 7.2579 2.4299 1.8526
PaTu 8902 GDSC2 4.9533 6.4035 2.8371 0.4027
Panc 03.27 GDSC2 4.977 7.5329 2.3832 2.5204
HuP-T4 GDSC2 4.9917 6.6998 2.739 0.646
Hs 766T GDSC2 5.0407 6.8566 2.699 0.9766
PL4 GDSC2 5.1343 9.1586 1.7401 4.3536
Panc 08.13 GDSC2 5.1425 7.5484 2.4638 1.431
KP-4 GDSC2 5.1882 6.7641 2.7987 0.3859
SUIT-2 GDSC2 5.2581 6.7078 2.8473 0.2571
KP-2 GDSC2 5.2744 6.8209 2.8124 0.3207
PaTu 8988t GDSC2 5.3259 6.5196 2.9386 0.1009
HPAC GDSC2 5.5022 7.1838 2.7696 0.3243
Capan-2 GDSC2 5.6142 9.8637 1.7063 3.8776
SU.86.86 GDSC2 5.6909 7.0772 2.8773 0.1098
SW1990 GDSC2 6.0316 7.712 2.7808 0.2189
KP-3 GDSC2 6.3325 8.534 2.6029 0.3648
HPAF-II GDSC2 6.4522 8.4445 2.6792 0.2128
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC2 3.6541 7.0372 1.7333 9.114
MPP 89 GDSC2 3.7452 6.2449 2.1964 4.4894
NCI-H2052 GDSC2 3.7765 6.3453 2.1703 4.5536
MSTO-211H GDSC2 3.971 10.2838 0.366 12.515
NCI-H28 GDSC2 4.0803 6.0116 2.5444 2.3287
IST-Mes1 GDSC2 4.9332 9.1643 1.6097 5.2092
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 1.7436 3.4773 -0.5891 0.8245
LNCaP clone FGC GDSC2 2.9366 6.008 1.6456 8.8411
22Rv1 GDSC2 4.9524 7.3582 2.446 1.6761
VCaP GDSC2 5.2016 6.7593 2.8059 0.3638
DU145 GDSC2 5.7604 7.7941 2.6477 0.4828
PC-3 GDSC2 5.8737 7.8241 2.6819 0.3667
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.2564 5.9964 2.6599 1.5968
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 800 GDSC2 0.8068 2.9373 -0.863 3.5154
SK-MEL-28 GDSC2 1.254 2.6301 -0.475 0.796
SK-MEL-3 GDSC2 1.4495 3.3159 -0.6626 1.422
CP66-MEL GDSC2 1.4635 2.8068 -0.4511 0.5359
A-388 GDSC2 1.5166 4.7678 -1.2698 4.5468
SK-MEL-31 GDSC2 1.5373 9.1652 -3.3731 16.036
SK-MEL-30 GDSC2 1.5552 2.9845 -0.48 0.5719
CP50-MEL-B GDSC2 1.5679 3.4278 -0.6507 1.238
MZ-MEL-7 GDSC2 1.7713 3.3468 -0.5267 0.5841
COLO 783 GDSC2 1.7808 3.3384 -0.5195 0.5547
MMAc-SF GDSC2 1.7981 8.8181 -3.0153 13.6574
Hs 940.T GDSC2 1.9311 3.4972 -0.5174 0.461
LB2518-MEL GDSC2 1.9358 3.4894 -0.5126 0.4449
LB373-MEL-D GDSC2 1.9615 3.4722 -0.4961 0.3869
Mel Ho GDSC2 2.0481 3.7202 -0.5529 0.501
SK-MEL-5 GDSC2 2.0885 11.7292 -4.2282 18.5398
451Lu GDSC2 2.1949 4.3544 -0.7325 1.0041
G-361 GDSC2 2.2091 3.2629 2.1231 8.7132
HMV-II GDSC2 2.2776 3.5948 2.0975 8.5882
RVH-421 GDSC2 2.2856 4.6803 -0.8204 1.2667
Hs 938.T GDSC2 2.3039 3.6546 -0.4333 0.1437
A-431 GDSC2 2.322 4.5379 -0.7483 0.9647
G-mel GDSC2 2.3293 3.9511 -0.5272 0.3091
VMRC-MELG GDSC2 2.3356 3.7539 -0.456 0.1715
SK-MEL-24 GDSC2 2.3857 3.575 2.2214 7.7111
A2058 GDSC2 2.4268 3.4884 2.2951 7.2662
HT-144 GDSC2 2.5372 3.3649 2.4535 6.2386
IGR-1 GDSC2 2.5603 3.681 2.371 6.5102
A101D GDSC2 2.9312 3.7843 2.7181 3.8513
LOX-IMVI GDSC2 2.9383 3.9938 2.63 4.2307
SK-MEL-1 GDSC2 2.9394 3.9143 2.6678 5.407
GAK GDSC2 2.9399 3.9249 2.6634 4.0737
WM793 GDSC2 3.0608 3.9529 2.7691 3.2562
DJM-1 GDSC2 3.1052 17.3674 -6.2515 23.2527
SH-4 GDSC2 3.2861 5.3672 2.2693 5.0774
COLO 792 GDSC2 3.3023 4.8211 2.5559 3.6807
UACC-257 GDSC2 3.3031 4.3931 2.7706 2.6594
MeWo GDSC2 3.4154 4.805 2.6568 3.9473
M14 GDSC2 3.5095 5.073 2.5974 3.0527
IPC-298 GDSC2 3.732 15.7768 -5.0366 18.187
Mel JuSo GDSC2 3.8906 6.5211 2.168 4.357
MZ-MEL-2 GDSC2 3.8912 15.9061 -4.9904 17.7242
COLO 829 GDSC2 3.9671 6.4439 2.2604 3.7956
IGR-37 GDSC2 4.1476 6.2148 2.4921 2.4621
WM278 GDSC2 4.1897 9.6811 0.8334 9.9894
WM115 GDSC2 4.3709 7.2757 2.136 3.7125
A-375 GDSC2 4.4165 7.2241 2.1902 3.4032
WT2-iPS GDSC2 4.6542 5.9379 2.8878 0.4281
UACC-62 GDSC2 4.6581 8.6898 1.6533 5.4354
SK-MEL-2 GDSC2 4.6725 5.8935 2.9128 0.3528
COLO 679 GDSC2 4.8338 6.8663 2.5947 1.2405
WM1552C GDSC2 5.0008 6.5857 2.7876 0.5053
CHL-1 GDSC2 5.1219 7.2928 2.5603 1.1147
IST-MEL1 GDSC2 5.2408 7.6074 2.4883 1.682
RPMI-7951 GDSC2 5.544 6.9534 2.8673 0.1488
WM35 GDSC2 5.5968 12.9294 0.2563 10.0446
EquiPSC Line K2 GDSC2 3.8271 6.2355 -0.7763 0.3299
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 1.4553 5.7765 -1.7839 7.6395
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE 441.T GDSC2 1.5128 3.2517 -0.605 1.0951
STS-0421 GDSC2 3.1992 5.6552 -0.8063 0.6233
Hs 633.T GDSC2 3.3129 4.5603 2.6952 3.9944
GCT GDSC2 3.5019 7.4032 1.4292 8.5959
Rh41 GDSC2 3.5742 6.9766 1.7004 7.1654
KYM-1 GDSC2 3.917 6.9757 1.9641 5.2598
SW982 GDSC2 4.0273 5.811 2.6047 2.14
EW-8 GDSC2 4.0473 6.6724 2.2059 3.9111
HT-1080 GDSC2 4.1072 6.0907 2.5245 2.3777
G-402 GDSC2 4.159 10.8822 0.2148 12.8003
A-204 GDSC2 4.1956 8.0021 1.664 6.1563
Rh30 GDSC2 4.2974 6.8075 2.3096 3.0495
G-401 GDSC2 4.5011 6.9808 2.3568 2.56
SW684 GDSC2 4.7245 6.0542 2.8734 0.4279
MES-SA GDSC2 4.7628 6.329 2.7821 0.6674
SK-LMS-1 GDSC2 4.87 8.3227 1.9637 3.7516
VA-ES-BJ GDSC2 5.2357 6.6568 2.8571 0.2461
SK-UT-1 GDSC2 5.4285 7.3685 2.6702 0.5848
RKN GDSC2 5.5588 6.8743 2.8998 0.1062
MFH-ino GDSC2 5.7088 7.6965 2.6631 0.6266
SW872 GDSC2 5.819 7.2898 2.85 0.1194
RD GDSC2 6.1007 7.9844 2.7111 0.2475
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCH GDSC2 1.2974 3.4883 -0.8184 2.4089
MKN7 GDSC2 1.6601 3.8579 -0.7842 1.7476
ECC12 GDSC2 1.9141 3.4142 -0.4936 0.4031
TMK-1 GDSC2 2.0335 4.0028 -0.6664 0.8852
ECC10 GDSC2 2.8955 8.4711 0.3839 14.7902
RF-48 GDSC2 3.1492 4.8281 -0.5358 0.1234
Hs 746.T GDSC2 3.2211 4.7948 2.4999 4.1289
AGS GDSC2 3.2879 4.476 2.7163 2.951
MKN28 GDSC2 3.3164 5.4792 2.2387 5.1556
MKN45 GDSC2 3.4969 4.7265 2.7596 2.3124
SNU-16 GDSC2 3.5146 5.0825 2.5966 4.0618
NUGC-3 GDSC2 3.5562 5.6919 2.3261 4.2419
NCI-N87 GDSC2 3.6408 9.5682 0.4604 12.7782
23132/87 GDSC2 3.6619 7.138 1.6893 7.0402
SNU-1 GDSC2 3.6837 5.2046 2.6624 2.4258
TGBC11TKB GDSC2 3.8194 6.2716 2.2384 5.5417
HSC-39 GDSC2 3.8728 6.8654 1.9857 6.9816
MKN1 GDSC2 4.1307 5.9431 2.6084 1.9775
Fu97 GDSC2 4.2738 6.9233 2.2394 4.529
HGC-27 GDSC2 4.3382 7.7806 1.8722 4.9568
SNU-5 GDSC2 4.3782 6.1276 2.6709 1.4102
KATO III GDSC2 4.673 9.9044 1.0774 8.0102
NUGC-4 GDSC2 4.8315 6.8205 2.6129 1.1776
IM95 GDSC2 5.6525 7.4424 2.7343 0.3411
GCIY GDSC2 5.6785 7.6209 2.679 0.4473
OCUM-1 GDSC2 6.0351 7.8526 2.7332 0.2299
RERF-GC-1B GDSC2 6.2219 8.4518 2.5898 0.4264
SK-GT-2 GDSC2 6.4161 8.5706 2.6216 0.308
SNG-M GDSC2 4.8459 8.3611 1.9308 3.9271
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC2 1.5085 4.4707 -1.1384 3.8209
ML-1 [Human leukemia] GDSC2 2.1022 3.811 -0.5647 0.5061
BHT-101 GDSC2 2.4211 3.9402 2.1211 8.0303
B-CPAP GDSC2 3.0979 4.1006 2.7331 3.3261
IHH-4 GDSC2 3.9609 6.7221 2.1205 4.4536
CAL-62 GDSC2 4.0845 7.876 1.6449 6.4432
8505C GDSC2 4.2481 6.6724 2.3414 2.9816
8305C GDSC2 4.2935 6.2398 2.5711 1.921
CGTH-W-1 GDSC2 4.4049 7.2237 2.1829 4.6015
ASH-3 GDSC2 5.1096 7.3312 2.5383 1.1989
TT GDSC2 5.1489 7.1504 2.6312 1.154
TT2609-C02 GDSC2 5.2545 9.5661 1.6258 4.6806
HTC-C3 GDSC2 5.7272 7.8948 2.596 0.6216
K5 GDSC2 5.7809 7.8094 2.6504 0.4682
WRO GDSC2 5.7904 7.4408 2.7874 0.2075
FTC-133 GDSC2 6.3765 18.2269 -1.7638 16.3321
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-15A GDSC2 1.3152 5.6221 -1.8048 8.0597
BB30-HNC GDSC2 1.4177 9.0384 -3.399 16.4501
SCC-25 GDSC2 1.6286 3.4928 -0.6481 1.1653
KON GDSC2 1.6349 4.6498 -1.1452 3.6499
KOSC-2 GDSC2 1.7075 7.0079 -2.2034 9.5069
BICR 31 GDSC2 1.7338 13.5472 -5.3885 23.5961
OSC-19 GDSC2 1.7711 3.8065 -0.7082 1.2815
PCI-06A GDSC2 2.1927 4.1448 -0.6527 0.7253
JHU-011 GDSC2 2.2297 12.4284 -4.4682 19.1791
BHY GDSC2 2.4555 4.1699 -0.5574 0.3294
PE/CA-PJ15 GDSC2 2.7627 4.9382 -0.7162 0.592
JHU-029 GDSC2 2.7691 5.0818 -0.7668 0.7344
PCI-04B GDSC2 3.0056 5.3666 -0.7771 0.6382
HO-1-u-1 GDSC2 3.0284 4.3332 2.5548 5.784
Detroit 562 GDSC2 3.3046 6.6864 1.6252 8.0927
HSC-3 GDSC2 3.5616 5.5151 2.4181 3.7967
DOK GDSC2 3.747 6.1581 2.2407 4.2786
OSC-20 GDSC2 3.9453 5.8177 2.5475 2.5196
Ca9-22 GDSC2 3.9757 7.0916 1.9503 5.2185
BICR 78 GDSC2 4.1497 6.7899 2.2199 3.6796
SCC-9 GDSC2 4.2823 7.3243 2.0535 4.2229
UPCI-SCC-090 GDSC2 4.2948 12.599 -0.5329 15.644
BICR 22 GDSC2 4.4536 6.0153 2.7604 0.9909
LB771-HNC GDSC2 4.4887 9.6538 1.0679 8.3739
HSC-4 GDSC2 4.6698 7.0085 2.4438 1.9892
SKN-3 GDSC2 4.7227 8.3463 1.8592 4.4178
CAL-33 GDSC2 4.7681 8.9111 1.6213 5.4074
HSC-2 GDSC2 4.8398 6.1733 2.8769 0.36
JHU-022 GDSC2 4.956 7.4328 2.4155 1.7883
BICR 10 GDSC2 5.0857 11.2823 0.6985 8.9947
PCI-30 GDSC2 5.2871 7.8203 2.4224 1.9328
BB49-HNC GDSC2 5.4531 7.8271 2.5004 1.0591
SCC-15 GDSC2 5.6166 8.2724 2.3968 1.2699
HO-1-N-1 GDSC2 5.6843 7.3441 2.782 0.2439
NCI-H3118 GDSC2 5.6852 15.7391 -1.0443 15.0046
FaDu GDSC2 5.853 12.5157 0.6245 8.1032
CAL-27 GDSC2 5.8839 7.6987 2.7311 0.2734
SAT [Human HNSCC] GDSC2 6.3065 10.1574 1.9544 2.2059
SAS GDSC2 6.9899 17.4235 -0.9562 12.579
SCC-4 GDSC2 7.9249 20.1729 -1.6455 13.576
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T24 GDSC2 2.1856 4.0382 -0.6154 0.6108
BFTC-905 GDSC2 2.6385 3.735 2.4333 5.9944
647V GDSC2 3.4357 4.74 2.7053 2.6891
RT-112 GDSC2 3.9544 5.8602 2.5333 2.5695
SW1710 GDSC2 4.0711 6.4633 2.3232 3.3362
HT-1197 GDSC2 4.1841 16.5601 -2.5931 22.9574
CAL-29 GDSC2 4.7668 6.917 2.5378 1.5153
639V GDSC2 4.778 6.7118 2.6315 1.1589
KU-19-19 GDSC2 4.8099 6.3461 2.7969 0.5918
SW780 GDSC2 5.0922 7.5365 2.4429 1.5521
TCCSUP GDSC2 5.4463 6.9977 2.8153 0.256
HT-1376 GDSC2 5.5082 8.7597 2.1363 3.0487
UM-UC-3 GDSC2 5.6624 7.367 2.7654 0.372
J82 GDSC2 5.7141 7.4738 2.7469 0.2966
5637 GDSC2 6.1335 8.1187 2.6758 0.2962
RT-4 GDSC2 7.5879 20.3509 -1.9534 15.0536
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JEG-3 GDSC2 1.523 11.8598 -4.7134 21.7594
SW954 GDSC2 1.896 4.1528 -0.79 1.5109
JAR GDSC2 1.9776 3.5857 -0.5314 0.4768
SW962 GDSC2 2.0894 4.0326 -0.6537 0.7987
ACC-OV7 GDSC2 2.0932 6.679 -1.7981 6.4798
OVCA433 GDSC2 2.4402 4.4762 -0.675 0.645
OMC-1 [Human cervical carcinoma] GDSC2 2.5223 4.3212 -0.5861 0.3689
NEC8 GDSC2 2.6075 3.5879 2.4563 5.9937
JHOS-3 GDSC2 2.8831 5.2119 -0.769 0.6783
OV17R GDSC2 3.041 5.4427 -0.791 0.6588
UWB1.289 GDSC2 3.0531 5.3914 -0.7674 0.5896
BPH-1 GDSC2 3.1643 6.3755 1.6619 8.2317
PA-1 GDSC2 3.3217 6.2409 1.8623 6.9313
NT2-D1 GDSC2 3.5434 5.2968 2.5125 4.5163
HEY GDSC2 4.0058 6.0032 2.4994 2.6421
CAL-39 GDSC2 4.0506 6.6868 2.2012 3.927
MS751 GDSC2 4.2186 6.2815 2.5059 2.3005
HeLa GDSC2 4.2543 6.6544 2.3539 2.9168
C-33 A GDSC2 4.3663 6.6319 2.4352 2.4041
C-4-I GDSC2 4.5222 6.0324 2.788 0.8316
DSH1 GDSC2 4.6489 6.8685 2.4943 1.8104
TC-YIK GDSC2 4.6618 6.7566 2.5508 1.5739
SiSo GDSC2 4.7538 6.8836 2.5453 1.5
SiHa GDSC2 5.0469 10.1691 1.2073 6.8165
OVMIU GDSC2 5.0874 8.9238 1.8199 4.0749
Ca Ski GDSC2 5.1896 8.021 2.2857 2.0448
SW756 GDSC2 5.2346 6.8204 2.7966 0.3707
PEO1 GDSC2 5.4099 8.1966 2.3261 1.6825
DoTc2 4510 GDSC2 5.4325 7.4899 2.625 0.7035
HEC-1 GDSC2 5.4899 7.1514 2.7766 0.3148
HT-3 GDSC2 5.4942 7.4533 2.6658 0.5627
NCC-IT GDSC2 5.6715 7.512 2.7164 0.4938
PWR-1E GDSC2 5.7813 7.7605 2.6687 0.4281
SKN GDSC2 5.79 7.6843 2.7001 0.3604
OVCA420 GDSC2 5.8134 8.1869 2.5206 0.7721
KGN GDSC2 6.1318 8.2729 2.6196 0.5322
LB831-BLC GDSC2 6.1326 7.8393 2.7732 0.1547
ME-180 GDSC2 6.4155 8.6272 2.6012 0.3427
SKG-IIIa GDSC2 7.638 21.6858 -2.5596 16.8296
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6.
2 Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203.
3 Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle. 2013 Jul 1;12(13):2113-9. doi: 10.4161/cc.25163. Epub 2013 Jun 10.