Details of the Drug

General Information of Drug (ID: DM9YI3K)

• Drug Name: US8598210, Table XV, 1
• Synonyms: US8722895, 1: {[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2- carbonyl]-amino}-acetic acid methyl ester; SCHEMBL1921387; CHEMBL3646212; LQWXMRRGVHUWEN-UHFFFAOYSA-N; BDBM107695; US8598210, Table XV, 1; {[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 320.73
  Logarithm of the Partition Coefficient (xlogp); 2.8
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C15H13ClN2O4
  IUPAC Name: methyl 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetate
  Canonical SMILES: COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC(=CC=C2)Cl)O
  InChI: InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
  InChIKey: LQWXMRRGVHUWEN-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 24891582
  TTD ID: D0Q9AF

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]

References

• [1] Prolyl hydroxylase inhibitors and methods of use. US8598210.