Details of the Drug

General Information of Drug (ID: DM9ZOMD)

Drug Name
CUDC-101
Synonyms
CUDC-101; 1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 434.5
Logarithm of the Partition Coefficient (xlogp) 4
Rotatable Bond Count (rotbonds) 12
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C24H26N4O4
IUPAC Name
7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide
Canonical SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
InChI
InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
InChIKey
PLIVFNIUGLLCEK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
24756910
CAS Number
1012054-59-9
UNII
1A7Y9MP123
DrugBank ID
DB12174
TTD ID
D0Z4RC
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Modulator [1]
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 5.84E-05 0.32 0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -0.8702 2.4648 -1.1951 41.6685
ES7 GDSC1 -4.0456 -1.6506 -4.0517 77.2309
EW-18 GDSC1 -3.9937 -1.5556 -4.001 76.592
ES5 GDSC1 -3.8893 -1.9934 -3.8906 76.7496
ES1 GDSC1 -3.0022 -1.4324 -3.003 66.7655
CHSA0108 GDSC1 -2.8393 0.4378 -2.9282 62.8601
EW-3 GDSC1 -2.6356 -0.2094 -2.6593 61.6688
ES8 GDSC1 -2.5245 0.7661 -2.6354 59.516
TC-71 GDSC1 -2.4926 -0.6685 -2.4974 60.4085
EW-16 GDSC1 -2.447 0.2654 -2.4964 59.2345
EW-1 GDSC1 -2.3607 -0.3486 -2.3712 58.7135
EW-11 GDSC1 -2.0949 0.2992 -2.1309 55.3502
U2OS GDSC1 -1.9493 0.6981 -2.0151 53.5488
NOS-1 [Human HNSCC] GDSC1 -1.8967 0.1442 -1.9156 53.0758
MHH-ES-1 GDSC1 -1.7131 -0.0883 -1.7191 50.8575
EW-13 GDSC1 -1.7112 3.4751 -2.4317 50.5801
EW-7 GDSC1 -1.6404 0.51 -1.6729 49.9587
SK-PN-DW GDSC1 -1.4667 1.4575 -1.6093 47.9949
SK-ES-1 GDSC1 -1.2487 -0.5531 -1.2487 45.0611
CADO-ES1 GDSC1 -1.163 1.2049 -1.2423 44.2849
EW-24 GDSC1 -1.1127 2.9214 -1.5978 44.7246
ES6 GDSC1 -0.7959 2.7221 -1.1903 41.0704
A-673 GDSC1 -0.1946 1.4095 -0.2377 32.1523
HuO9 GDSC1 0.8399 3.0695 0.4636 21.5003
SJSA-1 GDSC1 0.9908 3.7861 0.3279 21.6574
NY GDSC1 1.1607 6.3891 -0.7265 27.3604
ES4 GDSC1 1.4579 9.1565 -1.8188 30.9105
CHSA8926 GDSC1 1.987 2.6254 1.8575 5.5132
CHSA0011 GDSC1 2.1576 5.1075 0.8117 12.869
HuO-3N1 GDSC1 2.1643 5.2259 0.7584 13.2493
CAL-72 GDSC1 2.197 3.1889 1.8007 4.9931
CAL-78 GDSC1 2.3292 4.8019 1.1108 9.9078
G-292 clone A141B1 GDSC1 2.5639 5.6191 0.8944 10.7498
HOS GDSC1 4.1741 5.8011 1.8117 0.7624
SaOS-2 GDSC1 4.3073 6.1129 1.7492 0.9141
MG-63 GDSC1 4.5305 5.8347 1.9371 0.1879
H-EMC-SS GDSC1 5.6036 7.8386 1.6304 0.5116
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 144 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -3.8825 -2.2484 -3.8829 77.1535
Ku812 GDSC1 -7.8811 -6.0443 -7.8811 99.3046
SU-DHL-16 GDSC1 -6.8658 -5.6294 -6.8658 99.2405
Namalwa GDSC1 -6.2929 -3.3069 -6.2975 91.8311
ALL-PO GDSC1 -5.9358 -2.4976 -5.9514 88.2794
MY-M12 GDSC1 -5.8084 -3.2757 -5.8103 91.0165
WIL2 NS GDSC1 -5.6336 -3.8056 -5.6337 92.7281
SU-DHL-10 GDSC1 -5.5378 -4.1488 -5.5378 93.8319
CA46 GDSC1 -5.4239 -2.063 -5.4427 85.4407
SR GDSC1 -5.3384 -3.6897 -5.3385 91.3971
SU-DHL-8 GDSC1 -5.285 -3.5783 -5.285 90.7708
MOLT-13 GDSC1 -5.2584 -3.3753 -5.2586 89.898
ST486 GDSC1 -5.0395 -0.1636 -5.1925 77.7121
JSC-1 GDSC1 -4.843 -3.0718 -4.8432 86.8162
NU-DUL-1 GDSC1 -4.7473 -3.1705 -4.7473 86.5318
NB4 GDSC1 -4.6766 -3.3256 -4.6766 86.4609
ALL-SIL GDSC1 -4.6611 -3.1552 -4.6612 85.8843
MHH-PREB-1 GDSC1 -4.6427 -1.6547 -4.6585 80.9324
KOPN-8 GDSC1 -4.6351 -2.7513 -4.6355 84.5132
Daudi GDSC1 -4.6305 0.6259 -4.8754 73.8431
BL-41 GDSC1 -4.5826 -3.5272 -4.5826 86.1089
RPMI-8402 GDSC1 -4.5222 -2.9918 -4.5223 84.3937
SU-DHL-5 GDSC1 -4.4761 -3.4089 -4.4761 84.8781
BV-173 GDSC1 -4.4379 -3.4914 -4.4379 84.6079
SU-DHL-6 GDSC1 -4.4296 -2.3424 -4.4311 81.9136
OCI-Ly19 GDSC1 -4.3718 -2.1735 -4.3742 81.023
MOLP-8 GDSC1 -4.3013 -1.3494 -4.3201 78.0723
EoL-1 GDSC1 -4.2164 -2.6122 -4.2166 80.9502
VL51 GDSC1 -4.2137 -2.6973 -4.2138 81.1005
SU-DHL-4 GDSC1 -4.2051 -2.6302 -4.2053 80.8873
BE-13 GDSC1 -4.191 -2.8375 -4.191 81.1435
OCI-AML-5 GDSC1 -4.1557 -2.2681 -4.1566 79.6547
P12-Ichikawa GDSC1 -4.0398 -2.3279 -4.0402 78.7824
Karpas-45 GDSC1 -4.0355 -2.7136 -4.0355 79.3937
Sc-1 GDSC1 -4.0017 -2.1155 -4.0028 78.002
DB GDSC1 -3.9462 -2.2304 -3.9467 77.7309
Karpas-620 GDSC1 -3.9188 -1.6763 -3.9232 76.3044
VAL GDSC1 -3.8986 -1.423 -3.9073 75.5255
CCRF-CEM GDSC1 -3.8689 -2.1339 -3.8695 76.8254
RS4;11 GDSC1 -3.8429 -2.6246 -3.8429 77.2236
YT GDSC1 -3.8367 -1.6174 -3.841 75.4866
DND-41 GDSC1 -3.8208 -2.306 -3.821 76.6217
MC116 GDSC1 -3.8005 -2.9032 -3.8005 76.9021
Loucy GDSC1 -3.7942 -2.4623 -3.7942 76.5291
SIG-M5 GDSC1 -3.7938 -2.0934 -3.7943 76.0299
RPMI-6666 GDSC1 -3.7865 -0.7244 -3.8201 72.9163
QIMR-WIL GDSC1 -3.7605 -1.4358 -3.767 74.4377
PF-382 GDSC1 -3.7083 -2.069 -3.7088 75.137
MLMA GDSC1 -3.5892 -1.2473 -3.5973 72.5577
P32/ISH GDSC1 -3.578 -0.2752 -3.6349 70.2978
KMS-12-BM GDSC1 -3.577 -2.1134 -3.5772 73.8001
697 GDSC1 -3.5424 -2.072 -3.5426 73.3785
SUP-T1 GDSC1 -3.522 -1.8365 -3.5228 72.8967
MOLM-13 GDSC1 -3.5072 -0.851 -3.526 71.0269
HT GDSC1 -3.4499 -1.2043 -3.4568 71.2067
LC4-1 GDSC1 -3.4131 -1.362 -3.417 71.1164
Ramos.2G6.4C10 GDSC1 -3.3865 -2.0059 -3.3866 71.57
THP-1 GDSC1 -3.3765 -1.0142 -3.3868 70.1829
P30/OHK GDSC1 -3.3598 -1.9593 -3.36 71.2321
Reh GDSC1 -3.3527 -1.6783 -3.3535 70.9056
NKM-1 GDSC1 -3.3471 -1.5769 -3.3485 70.7333
RL GDSC1 -3.3112 -0.3502 -3.3508 68.3441
SUP-M2 GDSC1 -3.3012 -1.192 -3.3065 69.7476
SUP-B15 GDSC1 -3.2286 -1.9779 -3.2286 69.708
GDM-1 GDSC1 -3.2105 -0.6074 -3.2319 67.9307
RPMI-8866 GDSC1 -3.2085 -0.9802 -3.2169 68.5112
CESS GDSC1 -3.1708 -1.3448 -3.1729 68.5832
OCI-AML-2 GDSC1 -3.1171 0.3357 -3.2108 65.4238
BC-1 GDSC1 -3.0906 -1.2319 -3.0934 67.597
KE-37 GDSC1 -3.0725 -0.8314 -3.0824 66.9341
MV4-11 GDSC1 -3.0337 -1.4368 -3.0345 67.1312
Jiyoye GDSC1 -2.9657 -1.0332 -2.9699 66.0381
HC-1 GDSC1 -2.9649 -0.687 -2.977 65.6463
OCI-M1 GDSC1 -2.9072 -1.2717 -2.9084 65.5667
MOLT-4 GDSC1 -2.8416 -1.8699 -2.8416 64.9622
EJM GDSC1 -2.8413 -0.8622 -2.8469 64.5126
OCI-AML-3 GDSC1 -2.8112 -0.7432 -2.8189 64.0741
JJN-3 GDSC1 -2.7962 0.1606 -2.8535 62.8525
Raji GDSC1 -2.7867 1.0667 -2.9643 61.498
AMO1 GDSC1 -2.7815 -0.1767 -2.8122 63.1449
Farage GDSC1 -2.7522 -1.4357 -2.7525 63.7964
ATN-1 GDSC1 -2.7388 -1.6114 -2.7388 63.6646
ARH-77 GDSC1 -2.7218 -0.5141 -2.7345 62.8865
NALM-6 GDSC1 -2.7054 -1.564 -2.7055 63.2472
BALL-1 GDSC1 -2.7018 -1.0965 -2.7033 63.0724
Hs 445 GDSC1 -2.6249 -0.1514 -2.6515 61.4989
A3/Kawakami GDSC1 -2.5623 -1.3709 -2.5624 61.4581
HL-60 GDSC1 -2.5543 -1.4196 -2.5543 61.3643
EB2 GDSC1 -2.518 -0.0266 -2.5484 60.2457
MN-60 GDSC1 -2.4174 2.3191 -2.8433 57.0192
Mono-Mac-6 GDSC1 -2.397 1.1783 -2.5635 57.889
SUP-HD1 GDSC1 -2.3605 -0.1537 -2.3786 58.6029
HEL GDSC1 -2.3426 -0.7124 -2.3452 58.643
CTV-1 GDSC1 -2.3292 -0.5779 -2.3336 58.4398
GR-ST GDSC1 -2.2833 2.2289 -2.6729 55.9773
KCL-22 GDSC1 -2.1993 -0.139 -2.2138 56.7402
TUR GDSC1 -2.1401 -0.989 -2.1403 56.1956
CTB-1 GDSC1 -2.1202 41.2007 -20.9121 50.6019
OPM-2 GDSC1 -2.1057 0.8517 -2.2001 55.2006
KMOE-2 GDSC1 -2.0861 -0.639 -2.0877 55.5012
DEL GDSC1 -2.0181 -0.6784 -2.0191 54.6644
K-562 GDSC1 -1.9953 0.2093 -2.0212 54.2299
L-363 GDSC1 -1.9309 -0.4172 -1.9337 53.5664
TK [Human B-cell lymphoma] GDSC1 -1.9136 0.3176 -1.9435 53.2419
BC-3 GDSC1 -1.8322 -0.8081 -1.8324 52.3539
Karpas-299 GDSC1 -1.8296 -0.7876 -1.8297 52.3203
KG-1 GDSC1 -1.7986 -0.7426 -1.7988 51.9337
LP-1 GDSC1 -1.755 0.2319 -1.7739 51.3559
NOMO-1 GDSC1 -1.6743 1.1274 -1.778 50.3487
MOLT-16 GDSC1 -1.6353 -0.6378 -1.6355 49.8934
L-1236 GDSC1 -1.6233 -0.0158 -1.6297 49.7458
EM-2 GDSC1 -1.5397 0.6437 -1.5784 48.7441
ML-2 GDSC1 -1.5393 -0.2931 -1.5404 48.6948
HH [Human lymphoma] GDSC1 -1.5357 2.7377 -2.0012 48.9547
KMS-11 GDSC1 -1.5262 0.1483 -1.5355 48.5452
U266B1 GDSC1 -1.4949 -0.2536 -1.4962 48.1415
JVM-3 GDSC1 -1.4939 -0.0517 -1.4976 48.1338
WSU-NHL GDSC1 -1.4767 0.2572 -1.4889 47.9368
PL-21 GDSC1 -1.3246 2.4006 -1.673 46.7011
SCC-3 GDSC1 -1.2139 -0.4055 -1.2139 44.6253
RPMI-8226 GDSC1 -0.9009 0.2024 -0.9024 40.722
KY821 GDSC1 -0.7573 0.4435 -0.761 38.9405
SU-DHL-1 GDSC1 -0.6669 -0.0303 -0.6669 37.7877
HAL-01 GDSC1 -0.6237 0.9199 -0.6436 37.3668
MEG-01 GDSC1 -0.5639 1.5179 -0.6471 36.9763
SK-MM-2 GDSC1 -0.5465 6.1603 -2.2941 42.1666
JURL-MK1 GDSC1 -0.5259 1.1186 -0.5571 36.2125
ME1 GDSC1 -0.4772 1.2832 -0.5226 35.689
P31/FUJ GDSC1 -0.3053 0.3669 -0.3054 33.2686
DG-75 GDSC1 -0.1986 3.4226 -0.7816 35.1554
RC-K8 GDSC1 0.0091 0.9795 0.0047 29.3655
Granta-519 GDSC1 0.1926 2.4888 -0.0425 28.5473
U-698-M GDSC1 0.356 6.7601 -1.6743 35.481
LAMA-84 GDSC1 0.4662 2.0709 0.3639 24.2837
ROS-50 GDSC1 0.6897 2.819 0.3929 22.8093
Karpas-422 GDSC1 1.078 6.9461 -1.075 29.4838
HDLM-2 GDSC1 1.3533 3.5168 0.818 16.3203
JVM-2 GDSC1 1.7289 8.3104 -1.1586 27.0127
WSU-DLCL2 GDSC1 1.7907 8.1814 -1.0402 26.189
A4/Fukuda GDSC1 2.4073 13.1576 -3.002 31.285
L-540 GDSC1 4.1702 9.1237 0.3385 10.0572
L-428 GDSC1 4.4871 6.5139 1.6721 1.0909
KM-H2 GDSC1 4.5256 7.8452 1.1392 4.0075
H9 GDSC1 4.8319 6.5761 1.7885 0.4293
⏷ Show the Full List of 144 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 -3.5243 -1.3968 -3.5288 72.2483
ESO-26 GDSC1 -1.9409 0.0048 -1.9546 53.6317
SK-GT-4 GDSC1 -1.7242 0.9988 -1.8131 50.9282
OACM5.1 C GDSC1 -1.4258 1.3715 -1.5501 47.5013
KYSE-50 GDSC1 -1.3459 1.1192 -1.4258 46.4825
FLO-1 GDSC1 -1.1324 0.9856 -1.1828 43.8146
KYSE-220 GDSC1 -0.7135 1.6797 -0.8364 39.0134
KYAE-1 GDSC1 -0.4504 1.6282 -0.543 35.6261
ESO-51 GDSC1 -0.2225 1.2898 -0.2542 32.43
TE-12 GDSC1 2.3906 4.1202 1.5027 6.6066
HCE-4 GDSC1 5.4435 12.7891 -0.5666 12.4857
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -1.2207 1.4602 -1.3444 45.102
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC1 -4.9368 -2.3599 -4.9414 84.7922
SJNB-13 GDSC1 -3.6823 -1.9465 -3.683 74.6933
CHP-212 GDSC1 -3.3989 -0.6001 -3.4264 69.5891
MHH-NB-11 GDSC1 -3.2787 0.5216 -3.4068 66.345
TGW GDSC1 -3.0989 -1.1422 -3.1028 67.5915
CHP-134 GDSC1 -2.9431 0.1234 -3.0044 64.2745
KP-N-YS GDSC1 -2.8952 1.4911 -3.1639 61.7622
SJNB-6 GDSC1 -2.7887 -0.4912 -2.8038 63.5801
SJNB-7 GDSC1 -2.6258 0.8578 -2.7571 60.359
GI-ME-N GDSC1 -2.5733 0.6501 -2.6719 60.1122
SK-N-AS GDSC1 -2.2968 1.1896 -2.4575 56.9205
SK-N-MC-IXC GDSC1 -2.2776 -0.2787 -2.2887 57.7142
Kelly GDSC1 -2.0468 0.3829 -2.0873 54.7675
IMR-5 GDSC1 -1.9868 2.8926 -2.5401 53.0687
GOTO GDSC1 -1.4746 2.0764 -1.7515 48.2135
NB(TU)1 GDSC1 -1.3674 0.6024 -1.3952 46.6248
SK-N-SH GDSC1 -1.3201 1.2167 -1.4119 46.201
NH-12 GDSC1 -1.2968 2.43 -1.6508 46.4155
NB69 GDSC1 -0.824 0.576 -0.8326 39.801
KP-N-YN GDSC1 -0.7043 1.3995 -0.7796 38.6672
SK-N-BE(2)-M17 GDSC1 -0.1479 3.4155 -0.7246 34.551
SiMa GDSC1 0.4837 8.632 -2.4523 37.1699
SJNB-10 GDSC1 0.5534 3.2758 0.0787 25.6796
CHP-126 GDSC1 0.6545 8.8656 -2.4066 36.271
SK-N-DZ GDSC1 0.6874 4.9722 -0.5122 28.5618
SK-N-FI GDSC1 0.8866 3.4432 0.365 21.9391
SJNB-5 GDSC1 1.4275 7.5317 -1.0411 27.7348
LA-N-6 GDSC1 2.5908 9.114 -0.8293 22.0378
NB1 GDSC1 3.9406 8.7687 0.3548 10.5358
SJNB-14 GDSC1 4.0111 6.0721 1.6289 1.8535
SJNB-17 GDSC1 4.9315 16.3855 -2.6452 22.9877
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -1.0196 1.9819 -1.2329 43.0133
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-453 GDSC1 -3.8627 -2.3352 -3.8629 77.0913
OCUB-M GDSC1 -2.9096 -1.2513 -2.911 65.5821
HCC1599 GDSC1 -2.8504 -1.8695 -2.8504 65.0712
T-47D GDSC1 -2.6768 -0.7245 -2.6829 62.563
Evsa-T GDSC1 -2.6569 -0.7503 -2.6622 62.3545
ZR-75-30 GDSC1 -2.4548 -0.1225 -2.4774 59.6371
EFM-19 GDSC1 -2.4075 3.7422 -3.2777 55.8343
CAL-148 GDSC1 -2.3973 -0.9232 -2.3984 59.3593
MDA-MB-361 GDSC1 -2.2233 -0.4638 -2.2285 57.1365
HCC202 GDSC1 -2.2156 -0.0952 -2.2324 56.9116
AU565 GDSC1 -2.0957 0.0421 -2.1155 55.4596
HCC1428 GDSC1 -1.3705 0.4869 -1.3909 46.6441
HCC38 GDSC1 -1.2853 0.9806 -1.344 45.7033
HCC1806 GDSC1 -1.2844 1.323 -1.3899 45.8092
DU4475 GDSC1 -1.1696 1.2961 -1.2626 44.4068
HCC1500 GDSC1 -0.8888 1.5577 -1.0035 41.1043
HCC70 GDSC1 -0.8495 2.1695 -1.0931 41.1444
HCC2218 GDSC1 -0.8363 0.5416 -0.8439 39.9496
CAMA-1 GDSC1 -0.8083 2.9429 -1.2737 41.4409
MDA-MB-468 GDSC1 -0.8061 1.2901 -0.873 39.8788
HCC1569 GDSC1 -0.7822 2.3502 -1.0672 40.5206
MDA-MB-175-VII GDSC1 -0.5897 1.192 -0.6314 37.0671
MDA-MB-330 GDSC1 -0.5832 1.9613 -0.7531 37.6603
COLO 824 GDSC1 -0.5744 2.4928 -0.8804 38.1931
MFM-223 GDSC1 -0.557 0.9477 -0.5762 36.5304
MDA-MB-231 GDSC1 -0.5413 2.3594 -0.8068 37.6184
MDA-MB-157 GDSC1 -0.4157 1.2666 -0.4557 34.8912
HCC1937 GDSC1 -0.3235 1.2162 -0.3534 33.6799
EFM-192A GDSC1 0.004 2.1278 -0.1523 30.3833
HDQ-P1 GDSC1 0.0182 4.3793 -0.9342 34.4929
BT-20 GDSC1 0.1602 2.276 -0.019 28.5923
HCC1187 GDSC1 0.3307 2.7096 0.04 27.2022
HCC1419 GDSC1 0.3736 2.0605 0.2654 25.478
CAL-120 GDSC1 0.4467 6.5603 -1.4916 34.3573
Hs 578T GDSC1 0.5454 1.6805 0.5152 22.826
BT-549 GDSC1 0.7093 2.4014 0.5464 21.655
JIMT-1 GDSC1 0.9887 3.9486 0.2544 22.1783
UACC-893 GDSC1 1.0377 5.3332 -0.3358 25.7539
BT-474 GDSC1 1.1359 6.3215 -0.717 27.4278
HCC1954 GDSC1 1.193 4.9665 -0.0111 22.961
MRK-nu-1 GDSC1 1.2028 5.8471 -0.4239 25.4775
MDA-MB-436 GDSC1 1.3131 5.9919 -0.3904 24.7642
HCC2157 GDSC1 1.3678 3.6274 0.7835 16.5039
YMB-1-E GDSC1 1.6702 5.9247 -0.0277 20.8939
CAL-85-1 GDSC1 1.7735 37.4629 -15.6851 44.7857
MDA-MB-415 GDSC1 2.1815 3.4887 1.6384 6.3267
UACC-812 GDSC1 2.4396 3.5892 1.8077 4.0324
HCC1395 GDSC1 2.5768 5.2679 1.0798 9.2766
MCF-7 GDSC1 2.5852 6.1287 0.6572 12.4699
CAL-51 GDSC1 4.0819 9.0632 0.3089 10.4759
BT-483 GDSC1 5.1963 6.7692 1.8532 0.1677
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1 -5.4203 7.0111 -7.7367 65.5172
U-251MG GDSC1 -3.5511 -0.4092 -3.5964 70.4048
SF268 GDSC1 -2.8679 0.2606 -2.9388 63.3806
Daoy GDSC1 -2.6571 -0.8886 -2.6602 62.442
GB-1 GDSC1 -2.3955 -0.2875 -2.4089 59.0803
D-423MG GDSC1 -2.0714 1.0489 -2.1918 54.7331
D-566MG GDSC1 -2.0458 0.1748 -2.0714 54.8309
GI-1 GDSC1 -1.947 -0.0059 -1.9605 53.7073
GaMG GDSC1 -1.7224 -0.1069 -1.7281 50.9729
KINGS-1 GDSC1 -1.665 -0.1594 -1.6689 50.263
MOG-G-CCM GDSC1 -1.5799 0.9656 -1.655 49.25
MOG-G-UVW GDSC1 -1.5225 0.2945 -1.5376 48.5074
KS-1 [Human Krukenberg tumour] GDSC1 -1.3495 2.1196 -1.6259 46.8645
D-247MG GDSC1 -1.3384 0.4856 -1.3575 46.244
YKG-1 GDSC1 -1.1828 0.8358 -1.221 44.3895
D-336MG GDSC1 -1.1457 0.9038 -1.1884 43.95
8-MG-BA GDSC1 -0.9445 0.7919 -0.9684 41.3826
D-502MG GDSC1 -0.9276 1.5379 -1.0419 41.5714
A-172 GDSC1 -0.7566 0.2132 -0.7573 38.9135
AM-38 GDSC1 -0.7062 1.5029 -0.7975 38.7708
D-542MG GDSC1 -0.6519 1.7566 -0.7846 38.3115
M059J GDSC1 -0.6371 1.2374 -0.6867 37.7003
KNS-81-FD GDSC1 -0.5946 1.3634 -0.6573 37.2442
42-MG-BA GDSC1 -0.4969 1.3028 -0.5457 35.9537
KALS-1 GDSC1 -0.4284 2.8087 -0.8173 36.8705
SF539 GDSC1 -0.3436 2.3996 -0.6021 35.2239
SK-MG-1 GDSC1 -0.343 3.2357 -0.8692 36.5218
PFSK-1 GDSC1 -0.3421 0.9377 -0.3534 33.7982
NMC-G1 GDSC1 -0.2444 2.7777 -0.6073 34.5882
Onda 10 GDSC1 -0.2246 1.3571 -0.2634 32.5004
KNS-42 GDSC1 -0.1767 2.2996 -0.3928 32.9664
CAS-1 GDSC1 -0.1713 1.3495 -0.2063 31.8117
DBTRG-05MG GDSC1 -0.1146 2.6618 -0.4295 32.7777
YH-13 GDSC1 -0.0757 1.9291 -0.1946 31.1399
LN-229 GDSC1 -0.006 2.5872 -0.2884 31.2734
Becker GDSC1 0.0081 2.5574 -0.264 31.0397
SF295 GDSC1 0.0752 1.1123 0.0677 28.5587
DK-MG GDSC1 0.402 3.2216 -0.0625 27.448
U-118MG GDSC1 0.4342 2.6525 0.1709 25.7462
SF126 GDSC1 0.4378 1.9823 0.3515 24.5339
D-263MG GDSC1 0.5783 8.8532 -2.4714 36.7874
SNB-75 GDSC1 0.5788 4.1094 -0.2372 27.5444
Hs 683 GDSC1 0.7117 5.6727 -0.8139 30.0296
Onda 11 GDSC1 0.7598 3.5673 0.1807 23.8744
T98G GDSC1 0.807 7.526 -1.6111 33.0145
LN-18 GDSC1 0.8962 1.7268 0.8806 18.3474
SW1783 GDSC1 0.9392 1.8239 0.916 17.8586
U-87MG ATCC GDSC1 1.0592 1.6085 1.0564 16.2289
D-392MG GDSC1 1.1064 7.4911 -1.315 30.4265
LN-405 GDSC1 1.2311 3.4379 0.7267 17.5938
H4 GDSC1 2.3412 8.822 -0.8893 23.2683
SW1088 GDSC1 4.1475 10.5908 -0.3807 14.6179
D283 Med GDSC1 4.2245 5.3051 2.0098 0.1362
LNZTA3WT4 GDSC1 4.7656 7.0194 1.5973 1.1687
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -1.1877 2.3496 -1.5096 45.185
TGBC1TKB GDSC1 -0.6013 0.6619 -0.608 37.0093
TGBC24TKB GDSC1 -0.247 3.2856 -0.7835 35.4825
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1 -2.3454 -0.3947 -2.3543 58.5582
MFE-280 GDSC1 -2.1103 1.9445 -2.4123 54.6236
RL95-2 GDSC1 -2.0714 -0.2676 -2.0788 55.2592
KLE GDSC1 -1.0298 3.52 -1.7115 44.286
EN GDSC1 -0.6236 3.3777 -1.2225 39.8948
AN3-CA GDSC1 0.0202 2.8507 -0.3435 31.4348
MFE-296 GDSC1 2.3616 5.8142 0.6317 13.4605
MFE-319 GDSC1 2.5627 4.1397 1.6301 5.02
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1 -2.2834 0.8958 -2.396 57.0204
KTCTL-21 GDSC1 -2.0397 0.7071 -2.1119 54.5546
786-O GDSC1 -1.424 1.3264 -1.5406 47.4687
BB65-RCC GDSC1 -1.1251 0.6774 -1.1483 43.6205
KTCTL-140 GDSC1 -1.1007 1.9615 -1.3164 43.9545
LB1047-RCC GDSC1 -0.9523 0.7949 -0.9767 41.4824
KTCTL-195 GDSC1 -0.8205 2.1109 -1.0469 40.7402
KMRC-1 GDSC1 -0.7942 0.6857 -0.8066 39.4508
CAL-54 GDSC1 -0.6141 0.4457 -0.6162 37.1409
NCC021 GDSC1 -0.4579 1.8734 -0.5978 35.9789
769-P GDSC1 -0.1561 2.2432 -0.3556 32.6174
KTCTL-1M GDSC1 -0.0931 4.2596 -1.0004 35.471
ACHN GDSC1 -0.0925 2.7301 -0.4269 32.6221
Caki-1 GDSC1 0.3175 2.8678 -0.0268 27.7083
BFTC-909 GDSC1 0.5692 1.9122 0.5068 22.7363
SN12C GDSC1 0.6438 2.366 0.4848 22.4452
LB996-RCC GDSC1 0.9449 2.7973 0.6764 19.4472
LB2241-RCC GDSC1 1.0628 2.6535 0.8536 17.5674
KTCTL-26A GDSC1 1.6124 2.5059 1.4992 10.0535
UO-31 GDSC1 1.8494 2.6272 1.7111 7.2825
OS-RC-2 GDSC1 1.8939 4.657 0.8009 14.0096
KTCTL-13 GDSC1 2.0474 6.4027 0.0701 18.6728
SW13 GDSC1 2.3496 3.5096 1.7739 4.6155
RCC10RGB GDSC1 2.6091 8.8684 -0.6917 21.2237
A-498 GDSC1 3.3377 7.0595 0.7638 9.3127
VMRC-RCZ GDSC1 3.3439 9.6201 -0.4891 17.6031
KMRC-20 GDSC1 4.2106 6.0215 1.7425 1.0322
TK-10 GDSC1 4.3872 6.6379 1.5779 1.6512
SW156 GDSC1 4.3909 11.711 -0.7532 16.0608
HA7-RCC GDSC1 4.766 7.7522 1.3034 2.6563
VMRC-RCW GDSC1 5.0188 13.2156 -1.0468 15.988
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1 -2.4961 -0.6859 -2.5006 60.4578
SW837 GDSC1 -2.3769 -0.3397 -2.3881 58.8964
LS411N GDSC1 -2.3575 -0.3059 -2.3694 58.6545
SNU-61 GDSC1 -2.1843 0.2616 -2.2213 56.3805
SNU-175 GDSC1 -2.1471 -0.3711 -2.1533 56.1967
CCK-81 GDSC1 -2.066 -0.6814 -2.0672 55.2575
SW48 GDSC1 -1.9656 1.2178 -2.1054 53.5399
SNU-C2B GDSC1 -1.6667 0.7703 -1.7242 50.2707
CaR-1 GDSC1 -1.6088 0.6878 -1.6548 49.5801
SW620 GDSC1 -1.5433 -0.0625 -1.5474 48.7495
RKO GDSC1 -1.4149 1.3934 -1.5421 47.3794
COLO205 GDSC1 -1.3545 1.5086 -1.4975 46.7066
HT-29 GDSC1 -1.0883 0.8457 -1.1228 43.2117
GP5d GDSC1 -0.9278 0.5511 -0.938 41.1057
LS180 GDSC1 -0.7646 2.0789 -0.9781 40.0307
SNU-407 GDSC1 -0.5833 3.6901 -1.2941 39.851
SW1417 GDSC1 -0.4678 1.9688 -0.6293 36.2157
NCI-H747 GDSC1 -0.3366 1.3307 -0.379 33.9192
SNU-C5 GDSC1 -0.3288 2.6349 -0.6546 35.3959
LS123 GDSC1 -0.2972 0.8842 -0.3049 33.2145
LS1034 GDSC1 -0.2455 1.8778 -0.3683 33.2674
MDST8 GDSC1 -0.1238 0.232 -0.1238 30.9999
KM12 GDSC1 -0.0821 3.1823 -0.5687 33.3326
HCC2998 GDSC1 0.0831 1.6851 0.0212 28.8043
HT115 GDSC1 0.1672 1.9299 0.0687 27.989
HT-55 GDSC1 0.2199 1.452 0.1956 26.8566
COLO 320HSR GDSC1 0.4076 2.7601 0.107 26.3203
CW-2 GDSC1 0.4654 4.3186 -0.4449 29.3911
LS513 GDSC1 0.5922 4.3614 -0.3334 28.0471
SNU-C1 GDSC1 0.6118 3.8066 -0.0739 26.3462
C2BBe1 GDSC1 0.6618 4.6508 -0.3916 28.0118
LoVo GDSC1 0.7979 3.0523 0.4252 21.9937
T84 GDSC1 0.8899 4.2255 0.0306 24.1942
SW948 GDSC1 0.9518 3.2003 0.5321 20.4244
COLO 678 GDSC1 0.9729 3.7185 0.3387 21.6735
SNU-1040 GDSC1 1.1335 3.166 0.7381 18.0092
SW1116 GDSC1 1.1663 6.3221 -0.6886 27.1324
RCM-1 [Human ESC] GDSC1 1.1763 3.3308 0.7151 17.9546
NCI-H716 GDSC1 1.4661 6.0695 -0.286 23.437
SW626 GDSC1 1.7848 2.6808 1.6214 8.2649
CL-11 GDSC1 2.271 3.5374 1.6931 5.5456
HCT 15 GDSC1 2.3619 4.2917 1.3932 7.5725
SW1463 GDSC1 2.4155 3.9194 1.6234 5.5672
SNU-81 GDSC1 4.1787 6.084 1.7036 1.2499
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.9041 2.4514 -1.2283 42.0487
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 -5.4 -4.3645 -5.4 94.1974
SNU-387 GDSC1 -3.1822 -0.4995 -3.2081 67.4841
SNU-423 GDSC1 -2.8761 0.133 -2.9349 63.644
HLE GDSC1 -1.7455 0.2637 -1.7659 51.2389
JHH-4 GDSC1 -1.7242 1.534 -1.9023 50.8769
Huh-7 GDSC1 -1.6327 0.2011 -1.6466 49.8631
SNU-398 GDSC1 -1.5892 4.2475 -2.5815 49.565
SNU-475 GDSC1 -1.3442 1.4505 -1.4758 46.5656
JHH-2 GDSC1 -1.1464 0.0629 -1.1483 43.7923
SK-HEP-1 GDSC1 -0.9245 1.0317 -0.9681 41.2284
Hep 3B2.1-7 GDSC1 -0.3604 1.3288 -0.4041 34.2238
JHH-7 GDSC1 -0.1892 1.1825 -0.2101 31.9473
JHH-6 GDSC1 0.0921 2.5767 -0.1782 30.0025
Hep-G2/C3A GDSC1 0.931 1.9723 0.8864 18.0996
SNU-449 GDSC1 2.9535 10.8763 -1.4169 23.6896
HuH-1 GDSC1 4.0072 5.6403 1.8017 0.9567
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2731 GDSC1 -6.1617 -1.5787 -6.2308 85.3993
NCI-H2227 GDSC1 -5.1501 -3.0067 -5.1509 88.0811
COR-L321 GDSC1 -4.8877 -3.0636 -4.8879 87.0416
COR-L303 GDSC1 -4.8084 -2.7235 -4.8094 85.4493
HCC827 GDSC1 -4.6264 0.1475 -4.7944 75.1485
NCI-H810 GDSC1 -4.1896 -2.2342 -4.1907 79.8459
IST-SL1 GDSC1 -4.1538 -2.4252 -4.1542 79.9982
SBC-3 GDSC1 -3.9056 0.7342 -4.1128 69.9908
NCI-H292 GDSC1 -3.6674 -1.1041 -3.6807 72.918
NCI-H847 GDSC1 -3.5625 -1.9395 -3.563 73.4501
NCI-H510A GDSC1 -3.4552 -0.9779 -3.4681 70.8326
Ms-1 GDSC1 -3.1948 -1.1798 -3.1991 68.6466
NCI-H748 GDSC1 -3.053 -1.135 -3.0566 67.0897
NCI-H1755 GDSC1 -2.7502 -0.1309 -2.7827 62.7733
UMC-11 GDSC1 -2.7438 -1.1433 -2.7452 63.5897
Lu-135 GDSC1 -2.6877 -0.9373 -2.6905 62.8247
COR-L105 GDSC1 -2.6695 1.1804 -2.8581 60.3476
PC-14 GDSC1 -2.6542 -0.4133 -2.6691 62.0609
EPLC-272H GDSC1 -2.6326 -0.0955 -2.6629 61.5235
HCC78 GDSC1 -2.6029 -0.4316 -2.6159 61.5126
NCI-H3255 GDSC1 -2.598 0.3536 -2.6636 60.6869
NCI-H2171 GDSC1 -2.5696 -1.4291 -2.5697 61.5549
NCI-H1694 GDSC1 -2.5595 -0.9859 -2.561 61.3354
NCI-H211 GDSC1 -2.5456 -0.7913 -2.549 61.089
NCI-H1693 GDSC1 -2.4882 1.1473 -2.6564 58.7687
NCI-H446 GDSC1 -2.4243 -0.5886 -2.4297 59.5701
HCC33 GDSC1 -2.4227 -0.6126 -2.4277 59.5623
NCI-H2196 GDSC1 -2.3995 0.6208 -2.4833 58.4276
NCI-H345 GDSC1 -2.3467 0.2728 -2.392 58.1619
NCI-H196 GDSC1 -2.2395 -0.631 -2.2423 57.376
LC-2/ad GDSC1 -2.186 0.0357 -2.2084 56.5103
NCI-H1581 GDSC1 -2.1823 -1.0145 -2.1825 56.722
NCI-H64 GDSC1 -2.1352 -1.7898 -2.1352 56.1417
NCI-H1876 GDSC1 -2.0926 1.3632 -2.2684 54.7832
ABC-1 GDSC1 -2.0687 2.468 -2.5039 53.967
Lu-139 GDSC1 -2.0546 0.3781 -2.0951 54.8594
NCI-H1092 GDSC1 -2.021 0.42 -2.0634 54.4594
NCI-H1436 GDSC1 -1.9761 -0.0724 -1.9877 54.0703
NCI-H661 GDSC1 -1.9728 -0.5797 -1.9741 54.0957
NCI-H522 GDSC1 -1.9487 1.6927 -2.1788 53.1822
DMS 273 GDSC1 -1.9451 1.4746 -2.13 53.2277
NCI-H1648 GDSC1 -1.895 1.2573 -2.0361 52.7739
NCI-H2795 GDSC1 -1.883 2.4247 -2.2891 52.3008
CPC-N GDSC1 -1.8698 -0.6193 -1.8705 52.8197
NCI-H358 GDSC1 -1.8181 0.4834 -1.8564 52.0843
SBC-5 GDSC1 -1.7001 -0.515 -1.7007 50.7026
NCI-H520 GDSC1 -1.6811 2.7558 -2.1651 50.3528
NCI-H187 GDSC1 -1.6698 -0.7289 -1.6699 50.3244
Lu-134-A GDSC1 -1.655 -0.1696 -1.6585 50.138
EMC-BAC-1 GDSC1 -1.6149 7.1197 -3.8089 49.8321
NCI-H1944 GDSC1 -1.5626 0.738 -1.611 49.0276
NCI-H1688 GDSC1 -1.5001 -0.28 -1.5012 48.206
HOP-62 GDSC1 -1.4131 0.7481 -1.4548 47.2133
NCI-H322M GDSC1 -1.3443 2.5413 -1.7344 46.9649
NCI-H1836 GDSC1 -1.3324 0.3029 -1.3428 46.1432
EMC-BAC-2 GDSC1 -1.2151 1.1322 -1.288 44.8939
LK-2 GDSC1 -1.1949 0.301 -1.2022 44.4215
LCLC-97TM1 GDSC1 -1.1679 2.193 -1.4464 44.8723
NCI-H1734 GDSC1 -1.149 0.9154 -1.193 43.9951
COLO 668 GDSC1 -1.1489 1.0431 -1.2066 44.0416
SW1271 GDSC1 -1.128 0.525 -1.1425 43.6192
COR-L23 GDSC1 -1.1249 2.7912 -1.57 44.7694
NCI-H1915 GDSC1 -1.0524 2.1368 -1.3062 43.5107
COR-L88 GDSC1 -1.0344 -0.0505 -1.0348 42.3841
NCI-H526 GDSC1 -0.9887 0.6387 -1.0047 41.8942
NCI-H2110 GDSC1 -0.9719 1.2093 -1.039 41.9152
Calu-6 GDSC1 -0.9586 1.1739 -1.0204 41.7304
LCLC-103H GDSC1 -0.9517 0.5952 -0.9644 41.417
NCI-H1048 GDSC1 -0.9494 1.4492 -1.0503 41.7807
HARA [Human squamous cell lung carcinoma] GDSC1 -0.9059 2.0437 -1.1237 41.7068
SHP-77 GDSC1 -0.8653 1.5391 -0.9749 40.798
Lu-165 GDSC1 -0.8265 1.7595 -0.9743 40.4923
HCC44 GDSC1 -0.8178 0.9171 -0.8457 39.8286
NCI-H2135 GDSC1 -0.7845 0.459 -0.7889 39.2838
NCI-H226 GDSC1 -0.7722 0.5087 -0.7776 39.1368
NCI-H650 GDSC1 -0.7579 2.4688 -1.0738 40.3585
Lu-65 GDSC1 -0.7477 1.8661 -0.911 39.6131
SK-MES-1 GDSC1 -0.7467 2.9689 -1.2152 40.7794
NCI-H2373 GDSC1 -0.7434 1.0609 -0.7802 38.9504
NCI-H1623 GDSC1 -0.7357 1.8699 -0.8988 39.4684
LOU-NH91 GDSC1 -0.7269 0.3042 -0.7282 38.546
NCI-H2722 GDSC1 -0.6663 1.3911 -0.7377 38.1782
LXF 289 GDSC1 -0.55 1.1059 -0.5812 36.5128
NCI-H1770 GDSC1 -0.5348 0.581 -0.5382 36.1574
NCI-H2444 GDSC1 -0.5261 3.8298 -1.2862 39.4239
NCI-H2087 GDSC1 -0.5259 1.5822 -0.6166 36.5482
NCI-H3122 GDSC1 -0.4969 2.7423 -0.8709 37.5959
NCI-H2869 GDSC1 -0.4938 1.2037 -0.5315 35.8501
SBC-1 GDSC1 -0.475 0.8601 -0.4864 35.4595
NCI-H2347 GDSC1 -0.4028 2.7099 -0.7583 36.4146
Calu-3 GDSC1 -0.3741 5.2513 -1.7153 39.7506
PaCa-3 GDSC1 -0.3663 7.9848 -2.957 42.3502
NCI-H1781 GDSC1 -0.3417 1.422 -0.3955 34.0512
NCI-H838 GDSC1 -0.3333 1.8881 -0.4657 34.4065
NCI-H1993 GDSC1 -0.2968 3.1469 -0.7879 35.8347
NCI-H2030 GDSC1 -0.2861 1.4876 -0.345 33.3895
NCI-H2595 GDSC1 -0.2804 1.1557 -0.3031 33.0979
NCI-H1155 GDSC1 -0.2134 0.9754 -0.2227 32.1777
NCI-H647 GDSC1 -0.0672 1.4722 -0.1099 30.5598
NCI-H2029 GDSC1 -0.0046 2.0369 -0.1406 30.3638
NCI-H596 GDSC1 0.001 4.6124 -1.0515 35.1098
EBC-1 GDSC1 0.0822 3.1193 -0.369 31.2014
RERF-LC-Sq1 GDSC1 0.087 1.4887 0.0516 28.5877
BEN GDSC1 0.1264 1.9345 0.0236 28.5254
NCI-H1975 GDSC1 0.2279 2.0749 0.1038 27.3973
DMS 79 GDSC1 0.2299 1.4659 0.2047 26.7371
NCI-H1437 GDSC1 0.2495 3.0705 -0.1711 29.0135
NCI-H2369 GDSC1 0.3505 1.6184 0.3158 25.2907
NCI-H2170 GDSC1 0.3718 2.9545 0.002 27.2094
NCI-H2085 GDSC1 0.4624 4.7222 -0.6259 30.3991
NCI-H2461 GDSC1 0.5294 3.689 -0.1115 27.0386
SW1573 GDSC1 0.5433 2.5532 0.3206 24.1235
NCI-H524 GDSC1 0.5735 2.2247 0.445 23.1183
NCI-H2405 GDSC1 0.7002 3.2917 0.2289 23.8691
ChaGo-K-1 GDSC1 0.7632 2.1328 0.6733 20.4937
NCI-H1650 GDSC1 0.7938 4.3339 -0.1156 25.6374
CAL-12T GDSC1 0.8017 3.7851 0.1329 23.9738
SK-LU-1 GDSC1 0.8138 2.6415 0.5872 20.7867
NCI-H2804 GDSC1 0.8719 3.2615 0.4231 21.6114
NCI-H1666 GDSC1 0.9332 4.2097 0.0816 23.6342
Lu-99A GDSC1 0.9604 4.6488 -0.0911 24.625
NCI-H82 GDSC1 1.1139 2.3318 1.007 16.2287
NCI-H1299 GDSC1 1.1378 3.5111 0.5986 18.9905
NCI-H1563 GDSC1 1.1468 3.1842 0.7447 17.8927
IA-LM GDSC1 1.1998 4.7661 0.0903 22.2546
NCI-H23 GDSC1 1.2095 2.2414 1.1341 14.8236
NCI-H1869 GDSC1 1.2109 2.9 0.9248 16.2673
NCI-H727 GDSC1 1.2194 7.1497 -1.0433 28.6781
NCI-H2122 GDSC1 1.2668 3.8491 0.5815 18.4749
LC-1/sq GDSC1 1.3209 4.6473 0.2644 20.4837
NCI-H2141 GDSC1 1.3321 4.5414 0.3255 20.0021
RERF-LC-KJ GDSC1 1.3403 3.7623 0.6949 17.2896
NCI-H441 GDSC1 1.3663 3.2343 0.9539 15.2575
NCI-H2591 GDSC1 1.3699 5.3047 -0.0035 22.0774
RERF-LC-MS GDSC1 1.4084 2.8424 1.1577 13.5631
NCI-H1573 GDSC1 1.4241 2.9648 1.1262 13.7087
DMS 114 GDSC1 1.4267 3.6268 0.8435 15.7758
NCI-H1304 GDSC1 1.4449 3.0755 1.1027 13.7728
NCI-H1651 GDSC1 1.5023 3.0263 1.1833 12.8937
HOP-92 GDSC1 1.5495 3.0423 1.2259 12.3443
A-427 GDSC1 1.552 6.2209 -0.2815 23.0264
NCI-H2818 GDSC1 1.5897 6.0901 -0.1826 22.2441
NCI-H1793 GDSC1 1.5989 2.8653 1.3509 11.1808
NCI-H2081 GDSC1 1.6786 3.9625 0.9364 13.9079
NCI-H1703 GDSC1 1.7108 3.5612 1.1573 12.0827
NCI-H2023 GDSC1 1.7369 2.9496 1.46 9.6858
A-549 GDSC1 1.8691 7.1536 -0.4596 22.7417
EKVX GDSC1 2.0768 7.9474 -0.6756 23.1341
NCI-H2228 GDSC1 2.1191 5.4075 0.6286 14.4035
NCI-H1792 GDSC1 2.123 2.8365 1.9019 4.5266
NCI-H841 GDSC1 2.1776 5.1572 0.8042 12.849
NCI-H2342 GDSC1 2.1982 5.0005 0.9001 12.0346
NCI-H2803 GDSC1 2.5977 4.2998 1.5776 5.3192
NCI-H1963 GDSC1 2.6264 10.2601 -1.3729 24.6035
NCI-H460 GDSC1 2.6902 3.9772 1.8043 3.2813
NCI-H1838 GDSC1 2.8182 7.024 0.3952 13.5845
DMS 53 GDSC1 2.8204 5.7166 1.0454 8.7463
NCI-H513 GDSC1 3.0406 5.7103 1.2096 6.832
HCC15 GDSC1 3.0481 7.1278 0.5196 11.9492
NCI-H2009 GDSC1 3.0813 7.3406 0.4394 12.4175
COR-L95 GDSC1 3.0834 6.5286 0.8406 9.4877
NCI-H1355 GDSC1 3.3071 7.166 0.6903 9.9344
NCI-H209 GDSC1 3.7228 6.4479 1.3059 4.439
NCI-H1435 GDSC1 3.827 5.7182 1.685 1.7902
NCI-H2172 GDSC1 3.8968 5.717 1.7198 1.4984
LB647-SCLC GDSC1 4.2066 5.9838 1.7554 0.9774
NCI-H720 GDSC1 4.491 11.4452 -0.5558 14.7113
IST-SL2 GDSC1 4.5719 6.7287 1.6257 1.2207
NCI-H2291 GDSC1 4.5859 6.8682 1.5771 1.4347
NCI-H69 GDSC1 4.6768 6.8594 1.6207 1.1456
NCI-H1568 GDSC1 4.984 7.2038 1.6191 0.9034
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -1.4674 1.957 -1.7147 48.1092
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 -3.6919 1.9447 -4.1366 66.2066
KYSE-450 GDSC1 -2.8135 0.1656 -2.8721 63.0095
KYSE-180 GDSC1 -1.915 0.5692 -1.9656 53.1962
OE33 GDSC1 -1.6081 1.558 -1.7813 49.6052
T.T GDSC1 -1.1065 0.9442 -1.1511 43.4756
KYSE-270 GDSC1 -1.0327 2.4929 -1.3804 43.5495
TE-4 GDSC1 -0.4928 0.938 -0.509 35.7104
KYSE-510 GDSC1 -0.2232 2.4278 -0.4786 33.7544
OE21 GDSC1 0.1559 3.2234 -0.3273 30.5115
TE-10 GDSC1 0.3853 6.2281 -1.3948 34.313
EC-GI-10 GDSC1 0.4173 2.9181 0.0639 26.5462
KYSE-410 GDSC1 0.4476 3.4274 -0.0929 27.3804
KYSE-520 GDSC1 0.6075 5.2829 -0.7349 30.177
KYSE-70 GDSC1 0.6823 2.9144 0.3515 23.1331
KYSE-150 GDSC1 0.8024 5.0022 -0.4115 27.3876
OE19 GDSC1 1.2822 2.7119 1.0708 14.8526
TE-1 GDSC1 2.352 4.4247 1.3184 8.1965
TE-8 GDSC1 3.7125 5.9345 1.5309 2.9352
TE-9 GDSC1 3.9501 9.2762 0.1175 12.0761
COLO 680N GDSC1 4.2162 6.124 1.7048 1.2047
TE-11 GDSC1 4.3627 11.5061 -0.6737 15.7029
TE-6 GDSC1 4.401 14.3964 -2.0565 22.1291
KYSE-140 GDSC1 5.0526 8.1586 1.2751 2.4364
TE-5 GDSC1 5.615 12.7842 -0.457 11.5162
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OAW28 GDSC1 -3.5772 -0.9932 -3.5922 71.9217
RMG-I GDSC1 -2.6753 -0.1062 -2.7065 61.9784
OVCAR-8 GDSC1 -2.455 -0.2033 -2.4736 59.6982
OVKATE GDSC1 -1.9556 3.2541 -2.622 52.6777
EFO-27 GDSC1 -1.651 1.7324 -1.8638 50.0769
JHOS-2 GDSC1 -1.5068 3.7216 -2.298 48.8246
A2780 GDSC1 -1.489 0.1235 -1.4967 48.0806
TOV-112D GDSC1 -1.4607 0.2008 -1.4704 47.7339
ES-2 GDSC1 -1.3024 1.469 -1.434 46.0787
TYK-nu GDSC1 -1.2756 1.5679 -1.4233 45.8024
SK-OV-3 GDSC1 -1.2295 0.464 -1.2441 44.8812
OVCAR-5 GDSC1 -1.069 1.005 -1.1178 43.0309
OC 314 GDSC1 -0.9559 1.0183 -0.9998 41.6178
IGROV-1 GDSC1 -0.9418 1.7267 -1.0928 41.8844
OVISE GDSC1 -0.8234 0.6694 -0.8359 39.8157
OV-90 GDSC1 -0.253 2.6148 -0.5659 34.4268
Kuramochi GDSC1 -0.1758 1.3101 -0.207 31.8438
OV56 GDSC1 0.2152 1.4548 0.1904 26.9182
OVTOKO GDSC1 0.4869 3.8456 -0.2208 27.9526
OAW42 GDSC1 0.5853 2.0609 0.4954 22.7157
Caov-3 GDSC1 0.8297 3.9903 0.0731 24.2249
OVCAR-4 GDSC1 1.0138 3.7036 0.3874 21.1237
TOV-21G GDSC1 1.2275 2.7241 1.0075 15.5935
EFO-21 GDSC1 1.3881 4.9727 0.1738 20.7985
FU-OV-1 GDSC1 2.2729 6.3606 0.2842 16.317
DOV13 GDSC1 3.5265 6.0701 1.3602 4.4851
OVK18 GDSC1 4.3072 9.0523 0.4608 8.9148
OVCAR-3 GDSC1 4.4713 6.8332 1.5384 1.7569
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 02.03 GDSC1 -2.7188 -0.3277 -2.7392 62.6698
PSN1 GDSC1 -2.541 -0.3599 -2.5552 60.7702
HuP-T4 GDSC1 -2.2375 -0.1393 -2.2529 57.1846
PaTu 8902 GDSC1 -1.6826 0.4594 -1.7131 50.4687
Panc 10.05 GDSC1 -1.5011 1.2648 -1.6135 48.3588
HuP-T3 GDSC1 -1.2184 2.4755 -1.578 45.5902
QGP-1 GDSC1 -1.0868 3.9691 -1.9385 45.1311
BxPC-3 GDSC1 -1.0479 0.8879 -1.0841 42.7196
KP-2 GDSC1 -0.9229 1.6727 -1.0616 41.6114
Panc 03.27 GDSC1 -0.8196 1.3836 -0.9007 40.1118
HPAC GDSC1 -0.7762 1.9235 -0.9546 40.0203
MZ-PC-1 GDSC1 -0.5049 3.031 -0.9735 38.0955
SUIT-2 GDSC1 -0.3871 1.2526 -0.4239 34.5152
KP-4 GDSC1 -0.302 0.6866 -0.3044 33.2415
MIA PaCa-2 GDSC1 0.0295 0.9187 0.0269 29.099
SU.86.86 GDSC1 0.1108 0.9528 0.1086 28.0807
Panc 08.13 GDSC1 0.3204 3.5513 -0.2767 29.2392
DAN-G GDSC1 0.4683 1.4518 0.4553 23.6804
PaTu 8988t GDSC1 0.5222 2.3052 0.3684 23.9262
AsPC-1 GDSC1 0.6401 4.5136 -0.3521 27.8975
PL4 GDSC1 1.0203 5.6448 -0.501 26.8014
KP-3 GDSC1 1.0774 3.5786 0.5071 19.9519
Capan-1 GDSC1 1.4032 3.8668 0.7104 16.8743
HPAF-II GDSC1 1.5506 4.9954 0.317 19.0596
YAPC GDSC1 1.8348 4.4527 0.847 13.9074
Capan-2 GDSC1 1.8595 6.7424 -0.2635 21.5988
Hs 766T GDSC1 1.9257 3.9389 1.1826 10.9385
Panc 04.03 GDSC1 2.3461 6.5878 0.232 16.407
CFPAC-1 GDSC1 3.5831 9.3948 -0.2004 15.1353
SW1990 GDSC1 4.9447 12.5374 -0.7723 14.7519
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -2.2431 2.3642 -2.6653 55.5372
IST-Mes1 GDSC1 0.3646 1.397 0.3512 24.9786
MSTO-211H GDSC1 1.232 2.6572 1.0357 15.371
NCI-H28 GDSC1 3.4457 6.4288 1.1406 6.2635
NCI-H2452 GDSC1 4.0087 7.7636 0.8742 6.8083
NCI-H2052 GDSC1 4.17 9.0634 0.367 9.8694
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -3.7798 -0.2621 -3.8476 71.6912
22Rv1 GDSC1 -3.4312 -0.3643 -3.4746 69.3631
LNCaP clone FGC GDSC1 -2.5865 -0.0828 -2.6159 61.0261
PC-3 GDSC1 -1.3328 3.5339 -2.0433 47.2115
DU145 GDSC1 -1.1486 1.1105 -1.2145 44.0667
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 0.8341 2.5414 0.641 20.3047
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGR-1 GDSC1 -3.5403 -1.5304 -3.5432 72.6311
CHL-1 GDSC1 -3.4796 0.7424 -3.6556 67.3268
MZ-MEL-7 GDSC1 -3.211 -0.7576 -3.2262 68.1882
A-431 GDSC1 -2.5715 0.3221 -2.6325 60.4569
Mel Ho GDSC1 -2.4645 -0.3713 -2.4766 59.918
WM35 GDSC1 -2.0874 0.3652 -2.1284 55.2377
IGR-37 GDSC1 -1.9093 0.8232 -1.9874 53.0606
Mel JuSo GDSC1 -1.8917 0.5986 -1.9439 52.9201
G-mel GDSC1 -1.7755 0.2902 -1.7985 51.5996
LB373-MEL-D GDSC1 -1.5382 1.0732 -1.6247 48.7678
UACC-257 GDSC1 -1.522 1.6162 -1.6995 48.651
IPC-298 GDSC1 -1.4837 0.4416 -1.5053 48.0394
COLO 792 GDSC1 -1.4601 6.2609 -3.273 48.8181
SK-MEL-30 GDSC1 -1.4171 1.7482 -1.6131 47.4991
RPMI-7951 GDSC1 -1.3989 0.1191 -1.4049 46.9572
G-361 GDSC1 -1.3127 1.0742 -1.3845 46.0669
CP50-MEL-B GDSC1 -1.2652 0.1496 -1.2698 45.2869
IST-MEL1 GDSC1 -0.9699 0.6495 -0.9859 41.6602
LOX-IMVI GDSC1 -0.8538 0.4831 -0.8599 40.1596
A-375 GDSC1 -0.7985 0.7587 -0.8149 39.5268
SK-MEL-3 GDSC1 -0.7573 1.7676 -0.901 39.6413
SK-MEL-24 GDSC1 -0.6897 1.1322 -0.7308 38.3073
UACC-62 GDSC1 -0.6065 0.7087 -0.6149 37.0844
HMV-II GDSC1 -0.5207 1.9315 -0.6785 36.8408
MZ-MEL-2 GDSC1 -0.5124 1.262 -0.5575 36.1251
WM1552C GDSC1 -0.4879 0.7779 -0.4961 35.6006
A-388 GDSC1 -0.4569 1.3665 -0.5111 35.4877
COLO 829 GDSC1 -0.4511 2.424 -0.7263 36.5946
VMRC-MELG GDSC1 -0.3988 1.8712 -0.5332 35.2241
WM115 GDSC1 -0.3981 0.9348 -0.4109 34.5066
451Lu GDSC1 -0.3141 1.6449 -0.3991 33.8935
MeWo GDSC1 -0.2361 1.5911 -0.3066 32.8373
A101D GDSC1 -0.2127 1.1766 -0.2341 32.2442
MMAc-SF GDSC1 -0.1813 1.6807 -0.2622 32.2189
COLO 679 GDSC1 -0.1616 5.0346 -1.4021 37.4543
Hs 940.T GDSC1 -0.1452 2.8809 -0.5331 33.5468
M14 GDSC1 -0.0959 2.8067 -0.4552 32.8025
LB2518-MEL GDSC1 -0.0312 2.3247 -0.2408 31.1444
SK-MEL-2 GDSC1 -0.0095 2.1074 -0.1621 30.527
SK-MEL-28 GDSC1 0.0538 1.8203 -0.033 29.328
COLO 783 GDSC1 0.0556 2.6436 -0.2386 30.5939
WM793 GDSC1 0.1874 1.2248 0.1779 27.169
SK-MEL-1 GDSC1 0.266 2.24 0.1058 27.1571
GAK GDSC1 0.4117 1.6648 0.3752 24.5372
Hs 938.T GDSC1 0.7309 2.1897 0.625 21.0037
WM278 GDSC1 0.8622 3.7859 0.1952 23.2355
CP66-MEL GDSC1 1.0965 2.3123 0.9931 16.422
A2058 GDSC1 1.2461 4.6767 0.1777 21.4386
SH-4 GDSC1 1.2575 6.7439 -0.8093 27.3421
RVH-421 GDSC1 2.2553 8.5205 -0.8105 23.1755
SK-MEL-5 GDSC1 2.3086 7.4212 -0.2161 19.5208
WT2-iPS GDSC1 2.9419 7.5076 0.2508 14.1863
DJM-1 GDSC1 4.0549 7.5991 0.9787 5.9844
COLO 800 GDSC1 4.425 12.7341 -1.226 18.3938
HT-144 GDSC1 4.6384 5.9763 1.9269 0.1773
EquiPSC Line K2 GDSC1 0.524 5.6907 -1.007 31.9415
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -2.7193 -0.9666 -2.7221 63.2087
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-LMS-1 GDSC1 -2.7356 0.7218 -2.8547 61.5279
Hs 633.T GDSC1 -2.0511 -0.0369 -2.066 54.959
EW-8 GDSC1 -1.5975 1.5858 -1.7753 49.4897
Rh30 GDSC1 -1.5785 0.0981 -1.5873 49.1921
SW982 GDSC1 -0.8901 0.5336 -0.8987 40.6268
A-204 GDSC1 -0.6999 4.4933 -1.734 41.9258
MFH-ino GDSC1 -0.6305 1.3216 -0.6901 37.6727
RD GDSC1 -0.6114 5.8113 -2.2046 42.3823
G-401 GDSC1 -0.5343 2.5717 -0.8596 37.8111
Rh41 GDSC1 -0.1074 3.9128 -0.8739 34.9992
RKN GDSC1 0.164 1.9153 0.0681 28.0126
HT-1080 GDSC1 0.1682 3.0695 -0.2584 30.0288
KYM-1 GDSC1 0.2854 1.6535 0.2422 26.158
SW872 GDSC1 0.6234 1.8839 0.57 22.0009
VA-ES-BJ GDSC1 1.384 2.3464 1.2979 12.7165
G-402 GDSC1 2.3277 6.7433 0.1388 17.1197
MES-SA GDSC1 2.5081 7.5315 -0.106 18.0777
SK-UT-1 GDSC1 2.8741 5.0914 1.3925 5.9147
GCT GDSC1 3.2624 8.2726 0.1151 14.0837
SW684 GDSC1 3.4465 7.7052 0.5268 10.7034
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC1 -3.7507 -0.8274 -3.7774 72.9126
NUGC-4 GDSC1 -3.7089 4.6994 -5.0235 62.1562
NCI-N87 GDSC1 -3.3052 0.0015 -3.3736 67.5911
Hs 746.T GDSC1 -1.9883 2.1437 -2.3288 53.385
23132/87 GDSC1 -1.8893 7.6418 -4.3207 51.3217
SNU-1 GDSC1 -1.6936 0.7419 -1.7496 50.5893
AGS GDSC1 -1.5227 -0.4773 -1.523 48.4867
IM95 GDSC1 -1.2615 2.2404 -1.5609 45.9444
NUGC-3 GDSC1 -1.0176 1.2886 -1.0987 42.5299
HGC-27 GDSC1 -0.7946 2.7052 -1.1836 41.0375
GCIY GDSC1 -0.7755 3.2992 -1.3586 41.4546
MKN1 GDSC1 -0.6951 1.4251 -0.7735 38.5691
Fu97 GDSC1 -0.1358 1.3763 -0.1716 31.3731
MKN7 GDSC1 0.7341 2.2654 0.6099 21.0859
ECC10 GDSC1 0.8149 13.9382 -4.7647 40.2003
MKN28 GDSC1 0.8832 6.1506 -0.8747 29.4628
TMK-1 GDSC1 1.0023 3.6716 0.3894 21.1681
TGBC11TKB GDSC1 1.2567 5.478 -0.1946 23.8344
SNU-5 GDSC1 1.6706 2.3535 1.6087 8.9752
SNU-16 GDSC1 2.0692 3.4772 1.5417 7.5441
MKN45 GDSC1 2.1947 4.0169 1.3877 8.2427
SCH GDSC1 2.5289 3.7042 1.8201 3.6416
OCUM-1 GDSC1 3.6698 5.9325 1.5078 3.1685
HSC-39 GDSC1 3.8511 5.5064 1.7839 1.2129
RERF-GC-1B GDSC1 4.6032 11.4813 -0.4968 14.0913
SNG-M GDSC1 4.6164 8.0273 1.1089 4.0408
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 -2.2774 -0.3369 -2.2867 57.7361
ML-1 [Human leukemia] GDSC1 -1.5079 1.1738 -1.6067 48.424
TT2609-C02 GDSC1 -1.4187 0.6684 -1.4538 47.2691
8505C GDSC1 -1.3938 1.6258 -1.5625 47.1986
BHT-101 GDSC1 -1.3274 0.7202 -1.3626 46.1534
WRO GDSC1 -0.9181 0.7823 -0.9403 41.0458
IHH-4 GDSC1 -0.8153 0.3958 -0.8188 39.6635
CAL-62 GDSC1 -0.7259 2.2796 -0.9868 39.7712
K5 GDSC1 -0.5063 0.7301 -0.5132 35.8231
CGTH-W-1 GDSC1 -0.1051 0.8203 -0.1075 30.7809
HTC-C3 GDSC1 0.1329 1.9158 0.0343 28.4175
FTC-133 GDSC1 1.2052 2.756 0.972 15.9637
ASH-3 GDSC1 2.8532 7.2588 0.3057 14.0991
KMH-2 GDSC1 3.0051 6.8669 0.6162 11.3844
TT GDSC1 3.1298 7.0178 0.6344 10.8656
8305C GDSC1 4.7455 6.2229 1.8805 0.2373
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 -4.1274 -1.6326 -4.1349 77.7771
PCI-06A GDSC1 -3.8116 -2.0619 -3.8123 76.1507
Ca9-22 GDSC1 -3.237 -1.506 -3.2383 69.4691
SCC-25 GDSC1 -2.5514 0.0479 -2.5881 60.5304
BHY GDSC1 -2.5386 0.2015 -2.5869 60.2474
SAS GDSC1 -2.5153 0.1066 -2.5549 60.0959
SCC-9 GDSC1 -2.4131 0.1703 -2.4531 58.9548
CAL-27 GDSC1 -2.3712 -0.1679 -2.3891 58.7336
SKN-3 GDSC1 -2.2772 1.1338 -2.4267 56.7728
OSC-19 GDSC1 -2.1065 0.405 -2.1517 55.4353
PCI-04B GDSC1 -2.0453 0.5117 -2.0971 54.6996
KOSC-2 GDSC1 -2.0178 0.4727 -2.0647 54.4037
BICR 31 GDSC1 -1.8972 2.705 -2.3854 52.3486
BICR 78 GDSC1 -1.8273 0.6505 -1.8812 52.1639
HSC-4 GDSC1 -1.826 2.6359 -2.2874 51.7193
SCC-15 GDSC1 -1.7913 0.8576 -1.8662 51.7138
BB30-HNC GDSC1 -1.4618 0.9825 -1.5315 47.8463
DOK GDSC1 -1.4516 1.1431 -1.542 47.7547
SAT [Human HNSCC] GDSC1 -1.4038 1.8647 -1.6242 47.3825
JHU-011 GDSC1 -1.4007 0.3568 -1.4152 47.0022
OSC-20 GDSC1 -1.108 1.8775 -1.3053 43.9873
CAL-33 GDSC1 -1.0553 0.9743 -1.1002 42.8469
JHU-022 GDSC1 -0.8991 3.2666 -1.481 42.7407
PE/CA-PJ15 GDSC1 -0.8948 2.0304 -1.1084 41.5617
BICR 22 GDSC1 -0.8705 1.0904 -0.9173 40.5762
HSC-2 GDSC1 -0.8371 0.8317 -0.8594 40.0389
SCC-4 GDSC1 -0.5969 2.301 -0.8517 38.2272
PCI-38 GDSC1 -0.5639 2.1106 -0.767 37.5901
HO-1-u-1 GDSC1 -0.2968 1.5264 -0.362 33.5604
FaDu GDSC1 -0.1334 2.1883 -0.3168 32.2434
HO-1-N-1 GDSC1 -0.1279 1.3053 -0.1562 31.2272
HSC-3 GDSC1 -0.1015 1.2587 -0.1245 30.8648
Detroit 562 GDSC1 0.5428 3.0091 0.167 25.1545
BB49-HNC GDSC1 1.7632 4.1613 0.9219 13.6439
BICR 10 GDSC1 1.8926 3.2008 1.5049 8.6053
KON GDSC1 2.095 3.14 1.7298 5.9744
PCI-30 GDSC1 2.6452 5.6859 0.9256 10.2346
PCI-15A GDSC1 3.8059 7.8572 0.6998 8.5149
LB771-HNC GDSC1 4.0052 7.5491 0.9714 6.1444
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1 -4.3434 -2.8937 -4.3434 82.6685
RT-4 GDSC1 -2.2826 1.3983 -2.4806 56.6167
RT-112 GDSC1 -1.2914 1.3705 -1.4053 45.9117
CAL-29 GDSC1 -1.291 1.0735 -1.3613 45.8027
BFTC-905 GDSC1 -0.8742 1.7126 -1.0167 41.0432
UM-UC-3 GDSC1 -0.7078 1.8835 -0.8715 39.1352
SW1710 GDSC1 -0.6096 2.1398 -0.8241 38.1924
KU-19-19 GDSC1 -0.2842 0.578 -0.2851 33.0096
T24 GDSC1 0.2377 3.0222 -0.1666 29.056
639V GDSC1 0.4736 1.9719 0.3924 24.0534
TCCSUP GDSC1 0.56 2.1521 0.4476 23.1799
HT-1197 GDSC1 1.2715 2.7345 1.0511 15.049
647V GDSC1 1.6604 8.2435 -1.1857 27.4236
J82 GDSC1 2.1151 3.6442 1.5017 7.6655
HT-1376 GDSC1 2.3774 3.6506 1.7265 4.8894
SW780 GDSC1 2.924 5.9805 0.9927 8.8267
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -4.3259 -1.1467 -4.3542 77.5895
PA-1 GDSC1 -3.6739 -1.741 -3.6758 74.274
SW954 GDSC1 -3.4722 -1.0593 -3.483 71.1427
Ca Ski GDSC1 -2.6131 0.3534 -2.6795 60.8358
PEO1 GDSC1 -2.6072 1.3651 -2.8257 59.5856
C-33 A GDSC1 -2.5704 -0.5924 -2.5779 61.2643
DoTc2 4510 GDSC1 -2.4929 -0.3715 -2.5056 60.2394
DSH1 GDSC1 -2.4836 0.45 -2.5529 59.4395
OV17R GDSC1 -2.3998 0.5096 -2.4708 58.5285
NT2-D1 GDSC1 -2.1361 -0.4649 -2.1402 56.0848
HEY GDSC1 -2.0986 0.3035 -2.1351 55.3906
ME-180 GDSC1 -2.0933 0.7262 -2.171 55.1331
KGN GDSC1 -1.6232 0.9142 -1.6946 49.7575
NEC8 GDSC1 -1.579 -0.021 -1.5844 49.1944
OMC-1 [Human cervical carcinoma] GDSC1 -1.4356 1.392 -1.5641 47.6201
OVMIU GDSC1 -1.2696 0.7107 -1.3013 45.4338
UWB1.289 GDSC1 -0.9869 2.937 -1.4659 43.3944
LB831-BLC GDSC1 -0.7642 1.9733 -0.9528 39.9205
SKN GDSC1 -0.6599 1.2682 -0.7146 38.01
JAR GDSC1 -0.638 0.2969 -0.6388 37.4318
SW962 GDSC1 -0.5611 1.2565 -0.6084 36.7435
HT-3 GDSC1 -0.5157 1.5293 -0.5972 36.3715
OVCA433 GDSC1 -0.2765 1.1164 -0.2961 33.0296
NCC-IT GDSC1 -0.2756 1.3061 -0.3119 33.121
OVCA420 GDSC1 -0.2705 1.7455 -0.3697 33.4373
HEC-1 GDSC1 -0.1936 1.2331 -0.2187 32.0282
ACC-OV7 GDSC1 0.2338 2.0993 0.1047 27.356
SiSo GDSC1 0.3348 2.4758 0.1164 26.6819
CAL-39 GDSC1 0.3537 5.2873 -0.9907 32.7949
MS751 GDSC1 0.4207 2.8965 0.0751 26.453
C-4-I GDSC1 0.8186 1.6029 0.8091 19.2796
SW756 GDSC1 1.2687 4.4581 0.3027 20.4629
HeLa GDSC1 1.2775 2.995 0.9589 15.6747
JHOS-3 GDSC1 1.9327 6.4237 -0.0405 19.8731
SKG-IIIa GDSC1 2.0889 4.0872 1.2589 9.6699
SiHa GDSC1 3.7224 7.6034 0.7651 8.2672
JEG-3 GDSC1 4.3878 9.503 0.3008 9.7708
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73.