Details of the Drug

General Information of Drug (ID: DMAIJC9)

Drug Name

APX-001

Synonyms

EPI-0010; SSS-07; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Apexigen; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Epitomics

Indication

Disease Entry	ICD 11	Status	REF
Candidemia	1F23.3Y	Phase 2	[1]
Rheumatoid arthritis	FA20	Investigative	[2]
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Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C22H21N4O6P
Canonical SMILES: C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C([N+](=CC=C4)COP(=O)(O)[O-])N
InChI: 1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)
InChIKey: JQONJQKKVAHONF-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 44123754
CAS Number: 2091769-17-2
UNII: 1XQ871489P
DrugBank ID: DB15183
TTD ID: D0DL3W

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT03604705) An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia. U.S. National Institutes of Health.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.