Details of the Drug

General Information of Drug (ID: DMAZJFX)

• Drug Name: Ciclosporin
• Synonyms: Ciclosporin; Ciclosporin (Ciclosporin A); Ciclosporina; Ciclosporina [INN-Spanish]; Ciclosporine; Ciclosporine [INN-French]; Ciclosporinum; Ciclosporinum [INN-Latin]; Cipol N; Consupren; Cyclosporin; Cyclosporine A; Equoral; Antibiotic S 7481F1; Gengraf; Neoplanta; Neoral; Ramihyphin A; Restasis; S-Neoral; Sandimmun; Sandimmun Neoral; Sandimmune; Sang 35; Sang-35; SangCyA; Sigmasporin Microoral; cyclosporin A; cyclosporine; 59865-13-3; 83HN0GTJ6D; CHEBI:4031; CSA; DSSTox_CID_365; DSSTox_RID_75541; MFCD00274558; MLS001333756; UNII-83HN0GTJ6D

Indication

Disease Entry	ICD 11	Status	REF
Graft-versus-host disease	4B24	Approved	[1]
Psoriasis vulgaris	EA90	Approved	[2]
Brain injury	NA07.Z	Phase 4	[3]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[4]
Xerophthalmia	5B55.Y	Investigative	[2]

• Affected Organisms: Humans and other mammals
• ATC Code:
  L04AD01: Ciclosporin
  L04AD: Calcineurin inhibitors
  L04A: IMMUNOSUPPRESSANTS
  L04: IMMUNOSUPPRESSANTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04AD01: Ciclosporin
  L04AD: Calcineurin inhibitors
  L04A: IMMUNOSUPPRESSANTS
  L04: IMMUNOSUPPRESSANTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  S01XA18: Ciclosporin
  S01XA: Other ophthalmologicals
  S01X: OTHER OPHTHALMOLOGICALS
  S01: OPHTHALMOLOGICALS
  S: SENSORY ORGANS
• #Ro5 Violations (Lipinski): 4:
  Molecular Weight (mw); 1202.6
  Logarithm of the Partition Coefficient (xlogp); 7.5
  Rotatable Bond Count (rotbonds); 15
  Hydrogen Bond Donor Count (hbonddonor); 5
  Hydrogen Bond Acceptor Count (hbondacc); 12
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1-8 h [5]
  Bioavailability: The bioavailability of drug is 30% [5]
  Clearance: The clearance of drug is 22.5 L/h [6]
  Elimination: Cyclosporine excretion is primarily biliary with only 3-6% of the dose (including the parent drug and metabolites) excreted in the urine while 90% of the administered dose is eliminated in the bile [5]
  Half-life: The concentration or amount of drug in body reduced by one-half in 19 hours [6]
  Metabolism: The drug is metabolized via the liver [5]
  Vd: The volume of distribution (Vd) of drug is 4-8 L/kg [7]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Bone density decreased	Not Available	PTH	OTD721UF	[8]
Bone density decreased	Not Available	BGLAP	OTK1YLWQ	[8]
Haemolysis	Not Available	VWF	OTNMMA2P	[8]
Nephropathy toxic	Not Available	PPP3R1	OTGQNFJQ	[8]
Periodontal disease	rs231775	CTLA4	OTYQR611	[9]
Thrombosis	Not Available	THBD	OT8VHLKY	[8]
Thrombosis	Not Available	GNAQ	OTOODWTU	[8]
Type IV hypersensitivity reaction	HLA-B*39:01	HLA-B	OTNXFWY2	[10]

• Chemical Identifiers:
  Formula: C62H111N11O12
  IUPAC Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  Canonical SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
  InChI: PMATZTZNYRCHOR-CGLBZJNRSA-N
  InChIKey: 1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
• Cross-matching ID:
  PubChem CID: 5284373
  ChEBI ID: CHEBI:4031
  CAS Number: 59865-13-3
  UNII: 83HN0GTJ6D
  DrugBank ID: DB00091
  INTEDE ID: DR0321
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcineurin (PPP3CA)	TTA4LDE	PP2BA_HUMAN	Inhibitor	[2]
HUMAN cyclophilin D (CYP3)	TT95SAZ	PPIF_HUMAN	Inhibitor	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[11]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[12]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[13]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[14]
Cytochrome P450 3A5 (CYP3A5) Main DME	DEIBDNY	CP3A5_HUMAN	Substrate	[15]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[16]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Gene/Protein Processing	[17]
(E3-independent) E2 ubiquitin-conjugating enzyme	OTHGS2VA	UBE2O_HUMAN	Gene/Protein Processing	[18]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[18]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[19]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Gene/Protein Processing	[20]
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1)	OTX65INE	PLCA_HUMAN	Gene/Protein Processing	[18]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[18]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Gene/Protein Processing	[18]
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3)	OTAUR5TG	PLCC_HUMAN	Gene/Protein Processing	[18]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)	OTY829Z3	ABHD5_HUMAN	Gene/Protein Processing	[18]

Molecular Expression Atlas of This Drug

• The Studied Disease: Graft-versus-host disease
• ICD Disease Classification: 4B24

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Calcineurin (PPP3CA)	DTT	PPP3CA	5.29E-01	1.74E-03	9.99E-03
P-glycoprotein 1 (ABCB1)	DTP	P-GP	2.00E-01	2.57E-02	6.18E-02
Breast cancer resistance protein (ABCG2)	DTP	BCRP	6.07E-04	1.66E-01	4.54E-01
Multidrug resistance-associated protein 2 (ABCC2)	DTP	MRP2	7.41E-21	4.03E-01	1.33E+00
Cytochrome P450 3A5 (CYP3A5)	DME	CYP3A5	5.05E-02	4.52E-01	5.39E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	8.67E-01	-3.83E-03	-1.24E-02

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 139 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MEC1	CTRP2	6.6174	10.4327	3.5212	3.9259
JK1	CTRP2	6.8892	12.6082	2.6675	6.9145
JM1	CTRP2	5.1387	9.3768	2.9563	8.5915
KMS-34	CTRP2	-2.463	2.0953	-2.5714	50.0144
Karpas-620	CTRP2	-1.8331	3.3216	-2.0708	46.1499
Toledo	CTRP2	-1.205	9.3668	-3.3002	44.5577
PF-382	CTRP2	-1.0696	-0.0517	-1.0696	40.7321
KMS-27	CTRP2	-1.0086	-0.1152	-1.0086	40.3259
HDLM-2	CTRP2	-0.9947	2.1151	-1.0339	40.3483
KMS-26	CTRP2	-0.9945	-0.0738	-0.9945	40.2321
KMS-21-BM	CTRP2	-0.7447	3.3855	-0.91	39.0382
Mono-Mac-1	CTRP2	0.5406	5.7546	-0.0815	32.025
REC-1	CTRP2	0.7809	7.4616	-0.4358	32.2773
SK-MM-2	CTRP2	0.8168	5.0142	0.2281	25.4806
SEM	CTRP2	0.8699	5.1044	0.4721	29.1581
NALM-6	CTRP2	1.1315	5.4514	0.4082	23.7932
BL-70	CTRP2; CTRP1	1.2597	3.8212	1.1734	25.5783
KMS-28BM	CTRP2	1.4705	9.4942	-0.5764	30.5322
SUP-M2	CTRP2	1.6096	2.7791	1.6079	22.8889
Mino	CTRP2	1.6285	5.1547	1.0521	19.7229
TALL-1 [Human adult T-ALL]	CTRP2	1.6304	6.776	0.7354	25.8989
Ri-1	CTRP2	1.6962	16.2926	-3.5663	36.1655
EoL-1	CTRP2	1.724	3.0569	1.7189	22.138
GA-10	CTRP2	1.8344	3.7215	1.7944	21.5201
RCH-ACV	CTRP2	1.8887	13.9524	-2.2516	33.3603
DB	CTRP2	1.9687	6.6878	1.1302	23.4996
SUP-T11	CTRP2	2.0553	5.2588	1.7213	21.0875
A4/Fukuda	CTRP2	2.1534	8.189	0.2644	21.3809
GDM-1	CTRP1	2.1895	4.288	2.0992	41.4723
Daudi	CTRP2	2.2267	3.9337	2.1864	18.9077
Pfeiffer	CTRP2	2.3656	4.6215	2.2246	18.3323
Mono-Mac-6	CTRP2	2.5358	22.2812	-5.7446	37.1346
HH [Human lymphoma]	CTRP2	2.6253	4.9258	2.4358	16.7759
BDCM	CTRP2	2.6464	5.5827	2.2628	17.3441
KMS-12-BM	CTRP2	2.6704	3.8977	2.6546	15.8689
RPMI-8226	CTRP2; CTRP1	2.6813	4.4513	2.6012	16.0976
MOLP-8	CTRP2	2.7401	6.2228	2.1322	17.566
NCI-H929	CTRP2	2.8223	7.0415	1.8856	18.2848
NOMO-1	CTRP1	2.9506	4.5326	2.8774	30.6435
Ku812	CTRP2; CTRP1	2.9702	4.6244	2.8817	14.205
PL21	CTRP2; CTRP1	3.0057	5.9453	2.5261	15.4031
697	CTRP2	3.1267	8.115	1.7186	18.1354
EB1	CTRP2	3.1568	5.2926	2.9117	13.4431
THP-1	CTRP2; CTRP1	3.1705	4.8773	3.0446	13.0043
KMS-11	CTRP1	3.1976	5.0099	3.0407	27.7405
U-937	CTRP2; CTRP1	3.2911	5.5197	2.9867	12.8543
SKM-1	CTRP2; CTRP1	3.3032	4.0266	3.3	11.6958
AML-193	CTRP2	3.3176	4.4131	3.2872	11.607
MOLM-16	CTRP2; CTRP1	3.3337	4.9185	3.2125	11.9027
OPM-2	CTRP2	3.3531	4.5804	3.3014	11.4438
SU-DHL-5	CTRP1	3.3878	3.9733	3.3868	23.8802
MC116	CTRP2; CTRP1	3.4031	3.8625	3.403	11.0208
OCI-AML-3	CTRP2; CTRP1	3.4126	4.1374	3.4081	10.9723
HT	CTRP2; CTRP1	3.4138	4.6971	3.3478	11.1749
KE-97	CTRP2; CTRP1	3.42	5.0255	3.2793	11.3985
NU-DUL-1	CTRP2; CTRP1	3.433	4.3485	3.4165	10.8771
WSU-DLCL2	CTRP2; CTRP1	3.4604	3.9374	3.4601	10.6398
DEL	CTRP2	3.6087	3.9377	3.6087	9.5649
LP-1	CTRP2; CTRP1	3.7903	11.0756	0.9374	19.574
SET-2	CTRP2	3.8574	4.5469	3.8434	7.955
HD-MY-Z	CTRP2	3.9086	6.9661	3.0271	10.9603
MOLT-16	CTRP2	4.0197	12.1972	0.5819	20.2617
CA46	CTRP2	4.1501	7.5831	2.9699	10.6133
ST486	CTRP2	4.2417	8.5027	2.6079	11.8955
JVM-3	CTRP2	4.3254	9.6895	2.0985	13.7975
AMO1	CTRP2; CTRP1	4.4628	5.9068	4.0738	5.4507
Peer	CTRP2	4.615	12.4577	0.9741	17.5596
RL	CTRP2	4.6222	7.0742	3.0129	3.8274
Ci-1	CTRP2	4.6278	6.0979	3.489	1.7556
LAMA-84	CTRP2	4.6281	6.9393	2.2125	1.6313
HuT 78	CTRP2	4.6438	5.6275	4.3764	3.6907
RS4;11	CTRP2	4.6945	14.1321	-0.4384	18.1117
KM-H2	CTRP2	4.7789	7.7864	1.923	2.6232
P3HR-1	CTRP2; CTRP1	4.822	6.564	4.1008	4.5048
HuNS1	CTRP2	4.8655	9.9432	1.78	8.8351
HEL	CTRP2	5.2058	6.4839	2.6428	0.109
P12-Ichikawa	CTRP2	5.2357	7.7016	3.8717	4.5723
KE-37	CTRP2	5.2622	6.2363	4.6188	1.4101
L-1236	CTRP2	5.2886	16.7537	-0.608	21.472
SIG-M5	CTRP2	5.3686	6.2781	3.7913	0.1304
KMS-18	CTRP2	5.3847	15.0444	0.3251	18.3112
JeKo-1	CTRP2	5.3939	8.5549	2.8261	3.468
KMM-1	CTRP2	5.4421	7.7289	4.0175	3.6071
OCI-M1	CTRP2	5.6055	7.2925	3.5039	0.7086
HL-60	CTRP2	5.6156	6.9878	3.6281	0.369
OCI-Ly10	CTRP2; CTRP1	5.656	7.7802	4.158	2.7748
JURL-MK1	CTRP2	5.7439	8.7347	3.7447	4.2518
RPMI-6666	CTRP2	5.8549	21.5624	-2.5493	25.4456
HEL 92.1.7	CTRP2	5.8735	6.9514	3.741	0.0904
U266B1	CTRP2	5.9295	10.2909	3.1173	6.5394
EM-2	CTRP2	5.936	13.4988	1.5354	12.8913
TF-1	CTRP2	5.9722	9.2602	3.6507	4.2912
K-562	CTRP2	6.0167	7.7561	3.5048	0.4722
Jurkat	CTRP2	6.0906	13.9674	-0.1277	9.5106
SU-DHL-4	CTRP2; CTRP1	6.0932	8.4969	4.1064	2.3899
MOLM-13	CTRP2	6.2551	9.8415	3.5644	4.2351
MOLT-3	CTRP2	6.3015	7.3428	4.6995	0.2149
A3/Kawakami	CTRP2	6.3305	7.2813	4.7335	0.144
KCL-22	CTRP2	6.367	9.3671	3.0182	1.6765
Karpas-422	CTRP2	6.4135	11.8545	2.7019	7.4749
SU-DHL-8	CTRP2	6.458	8.7095	4.2127	1.5325
SU-DHL-1	CTRP2	6.4948	8.2933	4.4102	0.8563
Namalwa	CTRP2	6.5739	9.3501	3.9931	2.1957
MOTN-1	CTRP2	6.5794	8.0269	4.5565	0.4075
HPB-ALL	CTRP2	6.6196	14.5359	1.5388	11.7202
OCI-AML-5	CTRP2	6.6534	7.9737	4.6076	0.2661
P31/FUJ	CTRP2	6.6921	8.095	4.5781	0.3105
Kasumi-1	CTRP2	6.7064	14.6256	1.5585	11.5057
EHEB	CTRP2	6.7359	8.603	3.4799	0.2621
EJM	CTRP2; CTRP1	6.767	9.3627	4.1085	1.663
SU-DHL-10	CTRP2	6.7999	7.9511	4.6721	0.1203
RPMI-8402	CTRP2	6.8411	8.807	4.3661	0.7508
L-363	CTRP2	6.86	8.0382	4.6637	0.1189
Hs 611.T	CTRP2	6.8709	8.8936	4.3451	0.7901
OCI-Ly19	CTRP2	6.8872	9.1733	4.2382	1.0891
L-540	CTRP2	6.9239	10.8138	3.5348	3.5029
KYO-1	CTRP2	6.9912	8.2406	4.6411	0.1215
M-07e	CTRP2	7.0019	11.6277	3.206	4.661
NU-DHL-1	CTRP2	7.0119	15.916	1.1484	12.5412
KO52	CTRP2	7.0864	12.2355	2.9749	5.4461
MM1.S	CTRP2	7.1024	8.744	4.5031	0.3071
CML-T1	CTRP2	7.1597	12.6026	2.8493	5.837
JJN-3	CTRP2	7.1652	12.959	2.6843	6.4693
OCI-Ly3	CTRP2	7.1707	9.3484	4.3011	0.7307
Ki-JK	CTRP2	7.1787	9.011	4.4347	0.4139
L-428	CTRP2	7.2411	14.4464	2.0242	8.9144
Granta-519	CTRP2	7.2461	8.9497	4.4846	0.2934
KHM-1B	CTRP2	7.2766	21.3023	-1.3075	19.9257
NCO2	CTRP2	7.2884	16.522	1.0512	12.46
SR	CTRP2	7.3225	8.7854	4.5721	0.1426
MOLP-2	CTRP2	7.6423	16.8168	1.1575	11.5458
MHH-CALL-4	CTRP2	7.7634	9.7932	4.38	0.316
SUP-HD1	CTRP2	7.9125	9.8687	4.4097	0.232
Kasumi-2	CTRP2	7.9257	25.8162	-3.0489	23.1323
SUP-B15	CTRP2	8.097	17.5431	1.1196	11.0269
MOLM-6	CTRP2	8.6013	20.3342	0.1223	13.6657
F-36P	CTRP2	9.6694	19.8334	1.0568	9.2166
CMK	CTRP2	12.195	22.7722	1.1914	6.2257
KMS-20	CTRP2	12.4658	40.6133	-6.9989	24.3057

Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE15	CTRP2	5.8949	9.3608	3.5474	4.8281
TE8	CTRP2	6.5612	8.4471	3.4688	0.3329
TE-6	CTRP2	1.9842	7.9249	0.2223	22.0084
KYSE-140	CTRP2; CTRP1	3.567	6.4989	2.8957	12.4414
KYSE-410	CTRP2; CTRP1	3.6126	7.8749	2.3181	14.6277
TE-5	CTRP2	3.7317	5.6352	3.4161	9.892
TE-4	CTRP2	3.8109	12.3468	-0.2748	19.3767
KYSE-450	CTRP2; CTRP1	4.9639	8.6585	3.1793	8.0762
TE-11	CTRP2	4.9815	11.6306	1.0326	11.8253
KYSE-520	CTRP2	5.3496	10.9584	2.3378	10.7592
TE-14	CTRP2	5.6488	9.8723	3.1138	7.017
TE-10	CTRP2	5.7956	10.2376	3.0441	7.059
TE-9	CTRP2	6.5156	10.5883	3.3818	4.605
KYSE-180	CTRP2	6.6153	8.4006	3.5063	0.252
EC-GI-10	CTRP2	6.7444	10.9501	3.3596	4.3921
OE19	CTRP2	6.7615	8.5096	4.4482	0.5795
KYSE-70	CTRP2	7.244	9.8584	4.1295	1.159
KYSE-150	CTRP2	7.3088	8.5606	4.6442	0.0707
KYSE-510	CTRP2	7.3445	12.6053	2.9656	5.1566
COLO 680N	CTRP2	7.5458	8.8606	4.6251	0.0605
OE33	CTRP2	7.5538	9.3358	4.4641	0.2394
OE21	CTRP2	7.5866	9.5264	4.408	0.3214
TE-1	CTRP2	7.8961	9.5003	4.531	0.0969
KYSE-30	CTRP2	9.1644	15.1769	2.8598	3.6363

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	7.7168	9.6041	4.4301	0.2494
KP-3	CTRP2; CTRP1	2.9007	7.9293	1.5825	19.3193
Capan-2	CTRP2; CTRP1	3.7684	10.0545	1.4182	17.8174
CFPAC-1	CTRP2; CTRP1	3.7687	6.0657	3.2891	10.3648
Panc 03.27	CTRP2; CTRP1	3.9696	8.7519	2.2411	14.0912
Panc 10.05	CTRP2; CTRP1	4.0697	8.7937	2.3143	13.565
PaTu 8902	CTRP2; CTRP1	4.208	6.7808	3.4158	8.7373
QGP-1	CTRP2; CTRP1	4.3043	7.43	3.1978	9.4025
HPAC	CTRP2; CTRP1	4.5753	6.0404	4.1238	4.9709
HuP-T4	CTRP2; CTRP1	4.7917	9.3459	2.6889	10.4687
SNU-213	CTRP2	4.9206	9.8357	1.8746	8.3233
KP-4	CTRP2	5.1005	7.5995	3.8133	5.0673
SUIT-2	CTRP2; CTRP1	5.2257	6.994	4.2266	3.1861
PaTu 8988s	CTRP2	5.3601	13.1497	1.2517	15.0319
MIA PaCa-2	CTRP2	5.4514	7.6798	4.0487	3.4624
Capan-1	CTRP2	5.9061	13.0217	1.7491	12.1149
PSN1	CTRP2	5.9993	9.7997	3.4079	5.2389
SW1990	CTRP2	6.0397	7.9313	4.3218	1.5695
SU.86.86	CTRP2	6.1043	12.4159	1.4605	8.1512
HPAF-II	CTRP2	6.5006	13.1136	2.1496	9.5449
SNU-410	CTRP2	6.5406	14.6708	1.4141	12.3202
Hs 766T	CTRP2	6.6618	8.3042	4.4845	0.5415
HuP-T3	CTRP2	6.675	8.1611	3.6113	0.1038
PaTu 8988t	CTRP2	6.7511	7.7834	4.7126	0.0817
L3.3	CTRP2	6.8552	8.4671	4.5055	0.3975
YAPC	CTRP2	6.9005	8.2096	4.6183	0.1723
BxPC-3	CTRP2	6.9407	9.799	3.9995	1.8135
Panc 05.04	CTRP2	6.9632	8.7317	4.4502	0.4729
TCC-Pan2	CTRP2	6.9819	8.4508	4.5628	0.2389
KP-2	CTRP2	7.2949	8.8224	4.549	0.1784
Panc 02.03	CTRP2	7.5207	9.242	4.485	0.2506
AsPC-1	CTRP2	7.5618	16.3684	1.3183	11.0839
PK-45H	CTRP2	7.6768	9.4671	4.4637	0.2105
PK-59	CTRP2	7.8091	9.5599	4.4798	0.1628
Panc 04.03	CTRP2	7.8171	13.3715	2.9019	4.8375
DAN-G	CTRP2	10.1908	26.2072	-1.6161	16.518

Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	8.1733	10.4301	4.3083	0.3676
Malme-3M	CTRP2	3.021	18.4005	-3.3868	32.7724
Hs 852.T	CTRP2; CTRP1	3.2467	5.5917	2.9138	13.2553
COLO 741	CTRP2; CTRP1	3.2864	6.1764	2.7359	13.8193
G-361	CTRP2; CTRP1	3.3504	4.0893	3.3463	11.3847
Hs 944.T	CTRP2; CTRP1	3.7373	4.4552	3.7261	8.8335
WM115	CTRP2	3.7661	5.1889	3.6074	9.0769
Hs 936.T	CTRP2; CTRP1	4.0075	6.0468	3.5459	8.723
WM266-4	CTRP2	4.0199	5.4668	3.788	7.6655
A-375	CTRP2; CTRP1	4.388	5.49	4.1764	5.2432
SK-MEL-1	CTRP2; CTRP1	4.4933	6.5418	3.8059	6.4644
HT-144	CTRP2	4.5206	5.7458	4.1985	4.7154
UACC-257	CTRP2	4.5497	7.6416	3.3136	8.2895
SK-MEL-5	CTRP2; CTRP1	4.7584	5.6711	4.4768	3.093
SK-MEL-28	CTRP2; CTRP1	5.0013	5.9544	4.5623	2.1991
RVH-421	CTRP2	5.0067	7.3826	3.8437	5.12
MeWo	CTRP2	5.0197	7.5082	3.7918	5.3127
IGR-37	CTRP2	5.138	6.949	4.1689	3.5031
CJM [Human melanoma]	CTRP2	5.9728	7.6228	3.537	0.4173
RPMI-7951	CTRP2	6.0563	8.4874	4.0754	2.4838
SK-MEL-2	CTRP2	6.1387	7.3837	4.612	0.5109
Mel Ho	CTRP2	6.1452	7.923	3.4954	0.4357
WM88	CTRP2	6.2315	9.4181	3.7501	3.5301
HMCB	CTRP2	6.319	7.4988	4.6478	0.3185
Hs 688(A).T	CTRP2	6.3306	7.5815	4.6208	0.3767
Hs 895.T	CTRP2	6.4691	8.1482	4.4576	0.7336
Hs 294T	CTRP2	6.4964	9.2576	3.9895	2.2922
WT2-iPS	CTRP2	6.5161	7.5156	4.7202	0.117
A101D	CTRP2	6.5342	7.7002	4.6608	0.2072
IPC-298	CTRP2	6.5801	7.861	4.6198	0.2691
K029AX	CTRP2	6.6659	8.036	4.5894	0.2975
SK-MEL-30	CTRP2	6.6715	7.8513	4.6594	0.1687
Hs 839.T	CTRP2	6.7086	7.647	4.7441	0.0572
IGR-39	CTRP2	6.8225	8.3342	4.542	0.3334
SK-MEL-3	CTRP2	6.8417	10.6674	3.5522	3.5335
Hs 940.T	CTRP2	6.8497	9.6838	4.0003	1.8948
A2058	CTRP2	6.8852	7.9107	4.7164	0.0596
WM983B	CTRP2	6.906	10.6488	3.5997	3.2807
Mel JuSo	CTRP2	6.9194	8.2313	4.6178	0.1685
SK-MEL-24	CTRP2	6.9302	12.5592	2.7186	6.6563
SK-MEL-31	CTRP2	7.0479	8.3811	4.6128	0.1461
IGR-1	CTRP2	7.0481	8.3205	4.6339	0.1194
COLO 800	CTRP2	7.2205	8.884	4.4986	0.277
UACC-62	CTRP2	7.2227	8.4715	4.6443	0.0811
MDA-MB-435S	CTRP2	7.2272	8.5973	4.6028	0.1235
WM793	CTRP2	7.3245	8.8503	4.5502	0.1703
WM1799	CTRP2	7.4115	8.7124	4.6286	0.0717
LOX-IMVI	CTRP2	7.4698	9.2175	4.4744	0.2454
COLO 792	CTRP2	7.7604	10.6347	4.0581	1.0297
COLO 829	CTRP2	11.3921	26.2936	-0.8709	13.0531

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	CTRP2	4.9462	8.602	3.1831	8.0136

Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CHP-212	CTRP2	4.0158	10.665	1.3368	17.4929
SK-N-DZ	CTRP2	4.6827	6.2626	4.1127	4.6752
SK-N-AS	CTRP2	5.1917	8.6909	3.3424	6.8739
IMR-32	CTRP2	5.3489	6.5099	3.6975	0.3306
SK-N-FI	CTRP2	5.4228	10.5066	1.9112	7.316
Kelly	CTRP2	6.7554	12.7975	2.4845	7.83
MHH-NB-11	CTRP2	6.7614	8.4058	4.4888	0.4791
NH-6	CTRP2	6.9164	12.4678	2.7531	6.5398
SK-N-SH	CTRP2	7.0563	11.3153	3.3848	3.9134
CHP-126	CTRP2	7.0857	8.9239	4.4288	0.4657
SK-N-BE(2)	CTRP2	7.144	10.9785	3.5906	3.052
NB1	CTRP2	7.5246	8.894	4.6066	0.0769

Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuH-28	CTRP2	-1.0878	0.0684	-1.0879	40.8539
SNU-308	CTRP2	4.3141	9.9166	1.9758	14.318
HuCC-T1	CTRP2	4.8835	6.4202	4.2182	3.7962
SNU-478	CTRP2	6.4755	11.0378	3.1402	5.6218
SNU-869	CTRP2	7.19	13.5687	2.4105	7.498
SNU-1196	CTRP2	7.2598	8.5069	4.6453	0.0755

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-673	CTRP2	4.3847	6.0786	3.9105	6.2138
SK-ES-1	CTRP2	4.5284	7.8948	3.1693	8.937
SaOS-2	CTRP2	4.8887	7.8333	3.5181	6.7223
MG-63	CTRP2	5.1788	8.1307	2.887	3.5113
U2OS	CTRP1	5.2506	8.0673	3.7113	11.3084
SJSA-1	CTRP2	5.8962	8.5189	3.1357	1.6871
Hs 822.T	CTRP2	5.9082	6.9124	4.6944	0.4283
Hs 888.T	CTRP2	5.9567	10.4641	3.0521	6.7636
SK-N-MC	CTRP2	6.0327	14.6898	1.0185	14.6596
CAL-78	CTRP2	6.0901	8.4312	4.1229	2.2593
SW1353	CTRP2	6.1324	7.9875	3.4656	0.5108
TC71	CTRP2	6.3809	8.3439	4.3303	1.2031
RD-ES	CTRP2	6.5697	21.9794	-2.1879	23.3561
G-292 clone A141B1	CTRP2	6.9852	10.8499	3.5553	3.3563
HOS	CTRP2	7.1382	8.7053	4.5314	0.2458
MHH-ES-1	CTRP2	7.7951	9.3443	4.5486	0.094

Cancer Drug Sensitivity Data Curated from 66 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
DU4475	CTRP2	3.2777	4.8841	3.1577	12.1862
MCF-7	CTRP2; CTRP1	3.979	8.3949	2.4233	13.3292
HCC1395	CTRP2	4.7592	10.4203	2.1153	12.8174
CAL-85-1	CTRP2	4.8364	7.9176	3.431	7.1938
MDA-MB-453	CTRP2	5.2344	7.3849	4.0285	3.9173
HMC-1-8	CTRP2	5.4431	6.5664	3.7154	0.248
CAL-120	CTRP2	5.4538	6.686	4.5346	1.4695
HCC1419	CTRP2	5.7708	9.6713	3.3049	6.0221
AU565	CTRP2	5.8695	10.332	3.0527	6.9021
MDA-MB-415	CTRP2	5.8751	8.5191	3.9411	3.2578
ZR-75-30	CTRP2	5.9309	10.1176	3.2033	6.1834
HCC1937	CTRP2	6.3329	13.8674	1.6553	11.7477
KPL-1	CTRP2	6.3433	7.0543	4.8172	0.0386
CAMA-1	CTRP2	6.4277	7.8874	3.6173	0.1375
CAL-51	CTRP2	6.6566	9.935	3.7763	2.9047
ZR-75-1	CTRP2	6.7011	7.9174	4.647	0.1805
BT-20	CTRP2	6.8173	11.5175	3.1393	5.1572
JIMT-1	CTRP2	6.9162	8.0574	4.6774	0.0929
HCC1428	CTRP2	7.0463	8.5944	4.5358	0.2662
Hs 578Bst	CTRP2	7.2655	17.6235	0.4962	14.4324
BT-549	CTRP2	7.3689	9.59	4.2943	0.6437
HCC202	CTRP2	7.3826	9.6576	4.274	0.6857
HCC1954	CTRP2	7.385	9.8044	4.2173	0.8271
HCC38	CTRP2	7.3853	12.6364	2.9766	5.0649
MDA-MB-231	CTRP2	7.4164	9.255	4.4402	0.3182
HCC1806	CTRP2	7.5106	8.9598	4.5794	0.1033
HCC1143	CTRP2	8.0528	10.6449	4.1815	0.5908
MDA-MB-361	CTRP2	8.6591	17.153	1.6721	14.8666
Hs 578T	CTRP2	8.8979	24.9659	-1.9161	19.0453
HCC1500	CTRP2	8.9576	20.9817	0.0539	13.3872
MDA-MB-468	CTRP2	10.0268	20.0223	1.1877	8.3726
T-47D	CTRP2	10.0764	22.1252	0.2448	11.3455
BT 416	CTRP2	2.3025	3.5581	2.2932	18.2981
BT 131	CTRP2	2.616	3.8276	2.6027	16.2227
BT 248	CTRP2	2.758	4.2523	2.7124	15.387
BT 428	CTRP2	2.9211	6.478	2.2235	16.7142
BT 286	CTRP2	4.537	7.6903	3.278	8.4658
BT 271	CTRP2	4.7471	6.2388	4.1844	4.2328
BT147	CTRP2	5.0769	8.9891	3.0991	8.1118
BT 216	CTRP2	5.2117	8.4834	3.4622	6.3342
BT 422	CTRP2	5.5446	10.5474	2.6978	8.9228
BT 482	CTRP2	5.6535	9.5412	3.2813	6.3135
BT 172	CTRP2	5.6791	8.6492	3.7397	4.3736
BT 179	CTRP2	6.2428	7.6587	4.5494	0.6213
BT 320	CTRP2	6.257	7.3764	4.6683	0.3003
BT 444	CTRP2	6.3375	7.4465	4.6755	0.2498
BT 333	CTRP2	6.4336	7.9049	4.5394	0.5279
BT 145	CTRP2	6.5057	8.7522	4.22	1.4626
BT 498	CTRP2	6.5262	7.6756	4.6666	0.1993
BT 232	CTRP2	6.5506	8.7628	4.2396	1.3559
BT 245	CTRP2	6.5571	10.4734	3.4634	4.229
BT 504	CTRP2	6.6557	8.0686	4.5729	0.3361
BT 359	CTRP2	6.694	8.3923	4.4642	0.576
BT164	CTRP2	6.7047	7.7411	4.7105	0.0917
BT 231	CTRP2	6.7129	10.9541	3.3374	4.5191
BT 330	CTRP2	6.7752	8.6222	4.4098	0.6724
BT 340	CTRP2	6.8737	7.9922	4.6846	0.092
BT 328	CTRP2	6.9399	8.1001	4.6711	0.0958
BT 112	CTRP2	6.9968	8.312	4.6181	0.15
BT 159	CTRP2	7.0665	8.5789	4.5493	0.2368
BT 239	CTRP2	7.2281	14.406	2.0347	8.8929
BT 224	CTRP2	7.3822	8.513	4.6849	0.0363
BT 187	CTRP2	7.4132	11.8076	3.3735	3.554
BT 139	CTRP2	8.6525	16.0942	2.1584	6.5892
BT 440	CTRP2	9.4504	19.9589	0.8613	10.1309
BT 228	CTRP2	10.2602	20.6522	1.0398	8.597

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	2.6804	6.9629	1.7708	19.1098

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-466	CTRP2	-1.7097	-1.1292	-1.7097	44.9967
42-MG-BA	CTRP2	-0.4632	1481.7655	-737.9108	49.926
LN-18	CTRP2	-0.3941	0.7246	-0.3941	36.2321
SF539	CTRP2	3.3855	4.7119	3.3128	11.3013
SF268	CTRP2	3.7383	8.4201	2.1743	14.8237
Hs 683	CTRP2	4.2341	5.7594	3.8981	6.6515
KNS-60	CTRP2	4.5312	6.1954	3.3765	2.3848
D283 Med	CTRP2	4.6922	14.1856	0.1771	20.1973
SW1783	CTRP2	4.7761	11.3893	0.9933	12.3759
GaMG	CTRP2; CTRP1	5.0446	6.5538	4.2995	3.2163
SNU-489	CTRP2	5.1263	7.0713	4.0983	3.8214
SNU-626	CTRP2	5.133	8.2178	3.5309	6.1926
SF295	CTRP2; CTRP1	5.186	6.665	4.3591	2.7023
SNU-1105	CTRP2	5.3535	8.6162	2.7713	3.7518
SNU-738	CTRP2	5.457	6.8743	4.4463	1.8205
GB-1	CTRP2	5.6042	7.6335	4.1814	2.6788
DK-MG	CTRP2	5.8241	13.0188	1.6869	12.5029
U-87MG ATCC	CTRP2	5.8457	7.2427	3.6271	0.2762
KALS-1	CTRP2	5.9336	9.653	3.4325	5.2387
YH-13	CTRP2	6.0965	9.9023	3.4266	5.017
CCF-STTG1	CTRP2	6.2516	7.4946	4.6197	0.4217
CAS-1	CTRP2	6.392	8.2365	4.3822	1.0236
LN-229	CTRP2; CTRP1	6.5151	12.2063	2.6141	7.746
SF126	CTRP2	6.5564	8.1945	4.4802	0.6139
NMC-G1	CTRP2	6.5741	7.809	4.6367	0.2384
GMS-10	CTRP2	6.5757	8.1679	4.4996	0.5507
M059K	CTRP2	6.6276	10.7986	3.3556	4.5593
SNU-201	CTRP2	6.6617	7.9607	4.6157	0.2475
U-251MG	CTRP2	6.7206	13.4928	2.1225	9.3082
Becker	CTRP2	6.7241	11.0083	3.3191	4.576
Daoy	CTRP2	6.8186	10.1392	3.7797	2.7119
YKG-1	CTRP2	7.0024	8.4307	4.578	0.2079
GOS-3	CTRP2	7.02	8.9673	4.3836	0.6035
TM-31	CTRP2	7.0222	8.1084	4.6972	0.0597
A-172	CTRP2	7.0662	11.1139	3.4832	3.533
ONS-76	CTRP2	7.2884	9.3202	4.3635	0.5214
KNS-42	CTRP2	7.3864	8.8584	4.57	0.1333
DBTRG-05MG	CTRP2	7.438	8.9293	4.564	0.131
SW1088	CTRP2	7.5755	9.6102	4.3729	0.3885
8-MG-BA	CTRP2	7.6289	9.1921	4.5419	0.1237
T98G	CTRP2	7.9579	9.3558	4.6002	0.0433
SNB-75	CTRP2	9.7992	21.2299	0.4879	10.9174
U-118MG	CTRP2	11.7992	26.8348	-0.868	12.5836

Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HEC-151	CTRP2; CTRP1	2.166	4.5679	2.0211	19.7523
HEC-265	CTRP2; CTRP1	2.3158	4.3113	2.2313	18.5449
MFE-319	CTRP2; CTRP1	2.8309	12.5923	-0.6946	27.2159
HEC-6	CTRP2; CTRP1	3.4038	4.8327	3.309	11.3425
KLE	CTRP2; CTRP1	3.4327	5.1765	3.2507	11.4639
JHUEM-1	CTRP2	3.9184	4.5957	3.9028	7.5541
JHUEM-2	CTRP2; CTRP1	4.026	6.0608	3.5591	8.6221
HEC-108	CTRP2; CTRP1	4.1081	6.2063	3.5797	8.3269
HEC-1-A	CTRP2	4.1583	6.5208	3.4811	8.5084
HEC-251	CTRP2; CTRP1	4.3741	5.5067	4.155	5.3638
HEC-59	CTRP2; CTRP1	5.3964	6.8371	4.433	2.0447
JHUEM-7	CTRP2	6.2786	16.1299	0.4937	16.0878
HEC-1-B	CTRP2	6.3514	8.0213	3.5416	0.2683
JHUEM-3	CTRP2	6.6807	13.1146	2.2783	8.7571
ESS-1	CTRP2	6.7517	8.6921	4.3706	0.7949
MFE-296	CTRP2	7.3478	10.0127	4.1162	1.1271
EFE-184	CTRP2	7.4832	9.009	4.5528	0.136
AN3-CA	CTRP2	7.61	10.9283	3.8654	1.6899
HEC-50B	CTRP2	7.854	9.7309	4.4365	0.2083
EN	CTRP2	9.2916	20.3633	0.5694	11.2913
RL95-2	CTRP2	10.4476	21.7995	0.627	9.7095
Ishikawa (Heraklio) 02 ER-	CTRP2; CTRP1	4.834	8.2457	3.2744	7.9381

Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
VMRC-RCW	CTRP2; CTRP1	3.6393	5.5372	3.3569	10.4645
UO-31	CTRP2	4.0152	8.1108	2.5871	12.4964
CAL-54	CTRP2	4.6497	10.2062	2.1276	12.992
KMRC-3	CTRP2	4.7033	11.9283	1.3142	16.0988
TUHR4TKB	CTRP2	5.0313	7.6499	3.7307	5.5472
TUHR14TKB	CTRP2	5.1011	10.7225	2.2524	22.7134
SNU-1272	CTRP2	5.9241	12.2941	2.124	10.5984
TUHR10TKB	CTRP2	6.0369	9.4206	3.618	4.3289
VMRC-RCZ	CTRP2	6.4122	13.9179	1.6896	11.4838
RCC10RGB	CTRP2; CTRP1	6.4441	8.3992	4.3529	1.1329
BFTC-909	CTRP2	6.5654	8.1772	4.4912	0.5789
A-498	CTRP2	6.8817	8.0292	4.6747	0.1017
KMRC-2	CTRP2	7.2638	8.6361	4.6026	0.1174
KMRC-1	CTRP2	7.3035	12.9989	2.7554	6.0127
786-O	CTRP2	7.3414	8.7549	3.6395	0.029
OS-RC-2	CTRP2	7.4655	9.1573	4.4943	0.2164
769-P	CTRP2	7.497	9.2392	4.477	0.2343
Caki-1	CTRP2	7.5325	9.8349	4.2704	0.6213
KMRC-20	CTRP2	7.7041	9.0568	4.6136	0.0542
ACHN	CTRP2	7.733	9.2161	4.5703	0.083
Caki-2	CTRP2	9.0107	15.4508	2.6567	4.4579

Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-1033	CTRP2	0.6676	93.9901	-43.1265	48.1642
SW48	CTRP2; CTRP1	1.3892	3.9298	1.2963	24.7393
SNU-C4	CTRP1	1.7619	6.9003	0.8319	48.1615
HT115	CTRP2; CTRP1	2.945	6.6347	2.1897	16.8582
COLO 320	CTRP2; CTRP1	2.9984	10.2631	0.589	22.7298
HCT 8	CTRP2; CTRP1	2.9995	6.3327	2.3697	16.0164
GP2d	CTRP2; CTRP1	3.0304	5.8512	2.5876	15.1006
LS513	CTRP2; CTRP1	3.1841	4.3599	3.1528	12.5837
NCI-H747	CTRP2	3.2518	7.3356	2.1986	15.9311
C2BBe1	CTRP2; CTRP1	3.3314	14.1128	-0.9777	26.7857
SNU-175	CTRP1	3.3793	15.3357	-1.5386	41.9811
SK-CO-1	CTRP2; CTRP1	3.5254	4.8699	3.4329	10.5259
KM12	CTRP2; CTRP1	3.7001	6.8931	2.8579	12.246
CW-2	CTRP2; CTRP1	3.8106	5.692	3.4834	9.5006
SNU-81	CTRP1	3.836	5.4314	3.6068	19.2325
CL-40	CTRP1	3.8985	5.3	3.7193	17.9454
SNU-C5	CTRP2; CTRP1	3.9657	5.5898	3.6881	8.286
NCI-H508	CTRP2; CTRP1	4.0957	8.172	2.6414	12.1691
SNU-407	CTRP2	4.2036	10.46	1.6075	16.0254
LS180	CTRP2; CTRP1	4.4011	6.2855	3.8376	6.5558
SNU-C1	CTRP2	4.4176	6.9786	3.5156	7.7476
HCT 116	CTRP2; CTRP1	4.4411	6.0941	3.9662	5.9374
LoVo	CTRP2; CTRP1	4.5322	6.6589	3.7865	6.4535
RCM-1 [Human ESC]	CTRP2; CTRP1	4.5514	6.0309	4.1047	5.1062
SNU-C2A	CTRP2; CTRP1	4.6988	10.1455	2.2096	12.6337
SW1417	CTRP2	4.7586	9.5036	1.9164	8.4315
DLD-1	CTRP2; CTRP1	4.7939	5.6748	4.5095	2.8743
CL-34	CTRP1	4.8381	5.5548	4.6093	5.069
SW620	CTRP2; CTRP1	4.8714	6.0426	4.4032	3.1375
LS411N	CTRP2; CTRP1	4.9013	5.8594	4.5207	2.5834
SW480	CTRP1	4.9584	7.7223	3.6425	13.114
HT-29	CTRP2; CTRP1	4.9992	5.7315	4.6716	1.7453
MDST8	CTRP2; CTRP1	5.0026	6.27	4.4058	2.8531
COLO 678	CTRP2; CTRP1	5.1336	9.6059	2.8473	9.1358
SNU-61	CTRP2; CTRP1	5.6431	10.8625	2.6284	9.112
SNU-1040	CTRP1	5.7308	10.6123	2.8204	16.5722
LS123	CTRP2; CTRP1	5.8445	8.5415	3.9209	3.4596
SW403	CTRP1	5.8527	9.5253	3.4477	11.3228
SW948	CTRP2; CTRP1	5.9359	46.2292	-14.8001	38.9055
SNU-503	CTRP2	6.1796	26.2019	-4.6038	30.9056
HCC-56	CTRP2	6.2227	7.4719	4.6156	0.449
CL-11	CTRP2	6.4913	14.5863	1.4191	12.3832
HT-55	CTRP2; CTRP1	6.5235	8.5327	4.3372	1.1177
LS1034	CTRP2	6.7597	9.2684	4.1325	1.5287
HCT 15	CTRP2	6.7963	8.5418	3.5238	0.1838
COLO205	CTRP2; CTRP1	6.9431	8.1434	4.6716	0.1137
RKO	CTRP2; CTRP1	7.0562	8.3534	4.6397	0.1311
OUMS-23	CTRP2	7.2803	8.3465	4.7056	0.0321
NCI-H716	CTRP2	7.9786	9.734	4.4805	0.1335

Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuH-1	CTRP2	2.5462	8.3452	1.0301	22.2565
HuH-6	CTRP2	3.2556	10.0568	0.9266	20.8157
HLF	CTRP2	3.4709	5.0764	0.5504	0.2433
SNU-398	CTRP2; CTRP1	3.5893	4.8247	3.5124	10.0459
JHH-5	CTRP2	3.7449	6.3912	3.1201	11.0056
SNU-449	CTRP2; CTRP1	4.6143	7.3654	3.517	7.3864
Li-7	CTRP2	4.9835	12.9185	1.0565	16.5003
SNU-878	CTRP2	5.1486	6.6373	4.333	2.7951
SNU-761	CTRP2	5.1974	8.6879	2.6336	4.5619
PLC/PRF/5	CTRP2	5.4148	9.8273	2.9541	8.0905
JHH-1	CTRP2	6.0789	8.5634	4.0542	2.9357
Hep 3B2.1-7	CTRP2	6.3114	8.0224	3.5256	0.3098
SNU-182	CTRP2	6.5618	11.5298	2.9626	6.2088
SNU-423	CTRP2	6.6517	8.2052	3.588	0.1321
SNU-387	CTRP2	6.69	12.4941	2.5858	7.525
JHH-6	CTRP2; CTRP1	6.6929	7.5069	4.7998	0.0298
SNU-475	CTRP2	6.7744	8.0069	4.6429	0.1672
Hep-G2	CTRP2; CTRP1	6.933	8.0491	4.7005	0.0834
JHH-2	CTRP2	7.1459	10.4842	3.8118	2.2648
SK-HEP-1	CTRP2	7.3824	8.8501	4.5714	0.1324
JHH-4	CTRP2	7.4705	10.1741	4.1087	1.0684

Cancer Drug Sensitivity Data Curated from 154 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
DMS 53	CTRP2	0.2189	6.3148	-0.6163	34.6742
SK-MES-1	CTRP2	0.7439	5.5176	0.2138	30.4195
NCI-H1792	CTRP2; CTRP1	1.5464	5.2837	1.1619	24.7167
DMS 454	CTRP2	1.5508	6.6932	0.6819	26.3229
NCI-H1963	CTRP1	1.722	3.5064	1.6958	47.732
T3M-10	CTRP2; CTRP1	1.7401	8.7525	0.0336	27.9828
NCI-H1573	CTRP2; CTRP1	1.848	11.1219	-0.9373	30.4823
COR-L279	CTRP2; CTRP1	1.9266	4.5353	1.7679	21.3928
NCI-H1568	CTRP2; CTRP1	2.126	5.1619	1.8294	20.5587
SHP-77	CTRP2; CTRP1	2.1405	4.5458	1.998	19.9133
LCLC-97TM1	CTRP2; CTRP1	2.1675	6.8841	1.2687	22.4961
VMRC-LCD	CTRP2; CTRP1	2.4001	5.3447	2.0744	18.8447
LXF 289	CTRP2; CTRP1	2.4666	5.9833	1.9327	19.1734
NCI-H1373	CTRP2; CTRP1	2.4806	5.8347	2.0007	18.8795
NCI-H1048	CTRP1	2.5941	4.6791	2.4623	36.0696
SCLC-21H	CTRP1	2.7595	5.3002	2.4797	34.687
NCI-H82	CTRP1	2.7704	4.4934	2.69	33.2518
EBC-1	CTRP2; CTRP1	2.8813	4.2754	2.8416	14.6275
HCC78	CTRP2; CTRP1	2.8962	4.4505	2.8327	14.6103
LUDLU-1	CTRP2	3.0014	8.254	1.5296	19.1866
COR-L88	CTRP1	3.081	4.4599	3.0295	28.6262
LC-1/sq-SF	CTRP2; CTRP1	3.0839	5.1115	2.8889	13.8279
NCI-H1299	CTRP2; CTRP1	3.1905	5.7231	2.8065	13.8191
NCI-H1693	CTRP2	3.2064	7.5763	2.0443	16.6558
NCI-H2029	CTRP2; CTRP1	3.2343	8.7253	1.5478	18.6015
NCI-H3255	CTRP1	3.3326	7.6933	2.1245	32.6616
NCI-H810	CTRP2; CTRP1	3.3572	5.6799	3.0016	12.6081
NCI-H1930	CTRP1	3.4126	7.3101	2.3793	30.748
DMS 273	CTRP2; CTRP1	3.4182	5.0132	3.2807	11.3991
COLO 668	CTRP2; CTRP1	3.4738	7.8783	2.1798	15.5231
NCI-H2087	CTRP2	3.4982	14.7034	-1.1273	26.7475
NCI-H1435	CTRP2; CTRP1	3.5064	8.6419	1.8523	16.7427
NCI-H358	CTRP2; CTRP1	3.5247	8.3689	1.9995	16.1152
ChaGo-K-1	CTRP2; CTRP1	3.551	7.5064	2.4286	14.3377
NCI-H441	CTRP1	3.5591	6.6683	2.814	27.0299
HARA [Human squamous cell lung carcinoma]	CTRP2; CTRP1	3.5621	5.5128	3.2823	10.9663
HCC33	CTRP1	3.6577	5.194	3.4908	21.2751
Calu-6	CTRP2; CTRP1	3.6936	5.161	3.5398	9.628
EKVX	CTRP2	3.7271	10.7817	1.0155	19.363
NCI-H1666	CTRP2; CTRP1	3.7561	4.923	3.6718	8.9623
NCI-H1944	CTRP2; CTRP1	3.7728	6.9262	2.9162	11.829
NCI-H2141	CTRP2; CTRP1	3.7729	5.0871	3.6477	8.9974
NCI-H1437	CTRP1	3.8206	8.4599	2.2414	29.1217
EPLC-272H	CTRP2; CTRP1	3.9036	7.2618	2.8914	11.6045
NCI-H1838	CTRP2	3.904	8.3802	2.3516	13.7161
NCI-H2286	CTRP1	3.9275	5.6916	3.608	18.6618
HCC44	CTRP2; CTRP1	3.9308	9.0329	2.0681	14.8795
DV-90	CTRP2; CTRP1	3.9371	5.426	3.7179	8.2543
NCI-H1975	CTRP2; CTRP1	3.9427	5.9707	3.5107	9.0333
NCI-H2009	CTRP2; CTRP1	3.9947	7.5206	2.8582	11.5194
HCC4006	CTRP2; CTRP1	4.0242	5.8234	3.6573	8.2434
A-549	CTRP2; CTRP1	4.0579	6.7661	3.2747	9.6756
NCI-H1694	CTRP2; CTRP1	4.0719	5.5429	3.8195	7.4876
NCI-H2444	CTRP2	4.0909	6.2346	3.0168	4.7997
NCI-H2126	CTRP2; CTRP1	4.0993	8.6598	2.4073	13.1186
NCI-H2122	CTRP2; CTRP1	4.1082	8.5149	2.4863	12.7758
NCI-H596	CTRP1	4.2014	8.7954	2.4354	25.91
KNS-62	CTRP2; CTRP1	4.2131	7.2363	3.2044	9.5879
HCC2935	CTRP2; CTRP1	4.2968	5.4925	4.0787	5.8704
NCI-H2073	CTRP1	4.3124	10.3492	1.7685	29.0621
NCI-H211	CTRP2	4.3841	13.0027	0.5024	19.7404
NCI-H446	CTRP2	4.3979	5.5866	4.1418	5.2599
NCI-H2106	CTRP2	4.4207	9.1067	2.4726	12.0608
NCI-H1836	CTRP1	4.425	6.7264	3.6519	15.5401
SK-LU-1	CTRP2; CTRP1	4.4368	5.7691	4.1091	5.3767
Calu-3	CTRP2; CTRP1	4.4969	8.7994	2.7019	11.0295
NCI-H1155	CTRP2	4.5491	6.44	3.9005	5.858
NCI-H1395	CTRP2	4.5613	11.5529	0.7419	13.8373
HCC827	CTRP2; CTRP1	4.6085	5.4832	4.4103	3.7385
NCI-H1581	CTRP2	4.6305	7.0596	3.674	6.6123
NCI-H2170	CTRP2	4.633	7.5483	3.435	7.6029
NCI-H2081	CTRP2; CTRP1	4.6427	6.3271	4.0516	5.1071
NCI-H661	CTRP2; CTRP1	4.7352	6.663	3.9733	5.2239
NCI-H1355	CTRP2; CTRP1	4.7587	11.3521	1.6588	14.7205
NCI-H2405	CTRP2; CTRP1	4.7733	7.3454	3.6697	6.4088
HCC1195	CTRP2; CTRP1	4.8116	7.3857	3.6834	6.2711
HCC1438	CTRP2	4.8704	11.0115	1.9146	13.4032
COR-L51	CTRP2; CTRP1	4.8728	7.2991	3.7802	5.7394
NCI-H1092	CTRP2	4.9065	8.4189	2.5606	5.3387
NCI-H1876	CTRP1	4.9157	6.6042	4.1638	8.6789
BEN	CTRP2; CTRP1	4.9167	6.5496	4.1919	3.9244
HCC2108	CTRP2; CTRP1	4.9243	6.3091	4.3184	3.3793
Lu-65	CTRP2; CTRP1	4.9483	6.5598	4.2144	3.7656
NCI-H1781	CTRP1	4.9535	6.3617	4.3177	7.1302
DMS 79	CTRP2	4.9594	10.1737	1.737	8.8546
NCI-H522	CTRP2; CTRP1	5.012	7.4663	3.8159	5.3109
HCC1359	CTRP1	5.0391	5.8128	4.6653	3.6298
NCI-H2172	CTRP1	5.0572	6.6233	4.2753	7.0692
LCLC-103H	CTRP2; CTRP1	5.0704	6.5544	4.3207	3.0775
HOP-62	CTRP2	5.0766	9.2069	2.9899	8.5698
NCI-H2342	CTRP2; CTRP1	5.1199	10.978	2.15	12.0365
NCI-H727	CTRP2; CTRP1	5.1828	7.7544	3.8129	4.9981
NCI-H196	CTRP2	5.1898	11.33	2.022	12.3444
COR-L23	CTRP1	5.2027	6.3659	4.5211	4.2838
NCI-H1105	CTRP2; CTRP1	5.2242	7.788	3.8295	4.8526
CAL-12T	CTRP2; CTRP1	5.2609	10.9254	2.2923	11.1874
NCI-H1915	CTRP2; CTRP1	5.391	13.8315	0.9461	16.1757
NCI-H650	CTRP2; CTRP1	5.4277	7.0544	4.3493	2.3394
PC-14	CTRP2	5.4469	7.6958	3.2507	1.7117
NCI-H520	CTRP2	5.4776	8.5446	3.6409	5.1144
RERF-LC-KJ	CTRP1	5.4788	7.6851	4.0771	7.246
HCC1833	CTRP2; CTRP1	5.5157	11.5828	2.1693	11.2142
MOR/CPR	CTRP2	5.5475	6.5967	3.7454	0.1561
NCI-H1563	CTRP2	5.5952	7.6431	4.1705	2.7365
NCI-H2228	CTRP2	5.6628	11.5517	1.5728	8.3705
NCI-H1703	CTRP2	5.7011	8.4941	3.0393	2.2398
NCI-H2030	CTRP2; CTRP1	5.7485	9.1386	3.5613	5.0769
COR-L105	CTRP2	5.7731	9.03	3.6214	4.7127
NCI-H838	CTRP2	5.8796	7.4075	3.5796	0.3623
NCI-H1793	CTRP2; CTRP1	5.8962	11.0549	2.7269	8.2736
RERF-LC-Ad1	CTRP2	5.9496	13.7363	1.4278	13.2787
LK2	CTRP2	6.0137	8.5727	4.0079	2.8024
NCI-H322	CTRP2	6.0776	10.3073	3.2164	5.9013
NCI-H1755	CTRP2; CTRP1	6.1466	9.2976	3.7632	3.6663
NCI-H1650	CTRP2	6.1517	10.8394	3.0099	6.6292
NCI-H292	CTRP2	6.1802	13.075	1.9319	10.9263
NCI-H226	CTRP2	6.2227	7.4767	3.6851	0.0952
NCI-H2023	CTRP2; CTRP1	6.2418	12.7044	2.1716	9.9469
COR-L95	CTRP2	6.3625	7.6587	3.6723	0.0879
NCI-H2110	CTRP2; CTRP1	6.4121	12.6496	2.3237	9.0659
COLO 699	CTRP2; CTRP1	6.4131	12.0552	2.615	7.8981
RERF-LC-A1	CTRP2	6.4646	8.3708	4.3625	1.0275
NCI-H1341	CTRP2	6.5271	8.0614	3.5929	0.1487
SBC-5	CTRP2	6.5378	7.5393	4.7199	0.1126
HCC1588	CTRP2	6.61	7.9196	3.67	0.0611
HCC95	CTRP2	6.6368	8.1794	4.5223	0.4607
NCI-H647	CTRP2	6.6637	14.9058	1.3895	12.2106
HCC366	CTRP2	6.7523	8.5539	4.4265	0.6412
HCC2279	CTRP2	6.7601	14.6458	0.8352	9.6829
Sq-1	CTRP2; CTRP1	6.7863	10.3689	3.668	3.2297
Calu-1	CTRP2	6.8513	9.7268	3.9823	1.9553
SW1271	CTRP2	6.9339	8.9056	3.4469	0.2622
RERF-LC-Ad2	CTRP2	6.9367	8.4365	4.5502	0.2758
NCI-H460	CTRP2; CTRP1	7.1015	11.4709	3.353	4.0482
NCI-H2196	CTRP2	7.1275	28.9058	-5.8882	27.3284
IA-LM	CTRP2	7.1471	8.3401	4.6624	0.0745
LOU-NH91	CTRP2	7.1753	10.1559	3.97	1.7069
NCI-H2085	CTRP2	7.1765	9.187	4.3667	0.566
Lu-99	CTRP2; CTRP1	7.188	8.9621	4.4708	0.3715
NCI-H524	CTRP2	7.2821	31.3411	-6.2888	29.7678
NCI-H23	CTRP2; CTRP1	7.3152	16.4349	1.124	12.2213
NCI-H1339	CTRP2	7.3451	13.0186	2.7728	5.8925
NCI-H1184	CTRP2	7.5454	9.677	4.3358	0.473
HCC1171	CTRP2	7.703	13.9985	2.5415	6.3195
NCI-H1869	CTRP2	7.785	18.3772	0.5009	13.6143
NCI-H1651	CTRP2	7.9407	13.9798	2.6977	5.4493
HOP-92	CTRP2	8.008	15.7774	1.9011	15.2424
NCI-H1623	CTRP2	8.1027	17.1762	1.299	10.3828
NCI-H841	CTRP2; CTRP1	8.1445	19.6285	0.1578	14.2667
HCC15	CTRP2; CTRP1	8.2889	18.8803	0.6196	12.5381
RERF-LC-MS	CTRP2	9.9047	20.7753	0.7661	9.8938
SW1573	CTRP2	11.3643	26.8262	-1.1378	13.8101
DMS 114	CTRP2	14.6971	40.4982	-5.4278	19.4668
Hs 888.Lu	CTRP2	6.0428	11.6533	1.7838	6.9037

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
H-STS	CTRP2	6.5865	7.711	4.6772	0.1635
P-STS	CTRP2	7.108	8.7519	4.5025	0.3064
SYO-1	CTRP2	9.4691	19.5044	1.085	9.3615

Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Yamato-SS	CTRP2	7.0747	8.2872	4.655	0.0916
BT-16	CTRP2	3.1521	9.2683	1.204	20.0433
TE 441.T	CTRP2	3.4985	5.2954	3.2827	11.0652
G-401	CTRP2; CTRP1	3.8086	7.6449	2.6183	12.9406
A-204	CTRP2	3.8259	6.7158	3.0587	11.0405
MES-SA	CTRP2	4.1421	5.0829	4.0489	6.3387
TE 617.T	CTRP2	4.2098	6.1409	3.7061	7.4754
Hs 729.T	CTRP2	4.723	8.0818	3.2502	8.1851
HT-1080	CTRP2; CTRP1	5.0707	6.42	4.3882	2.7937
GCT	CTRP2	5.2987	8.6268	3.4604	6.1827
RKN	CTRP2; CTRP1	5.3381	6.6186	4.4977	1.8699
BT-12	CTRP2	6.0052	6.682	4.8242	0.0887
TTC-709	CTRP2	6.3905	9.0154	4.0369	2.2343
SK-LMS-1	CTRP2	6.653	11.9096	2.8423	6.558
SW982	CTRP2	6.8292	8.2903	4.5612	0.2926
Rh41	CTRP2	7.151	8.7734	4.5116	0.2758
G-402	CTRP2	7.2519	14.3477	2.0791	8.6888
KYM-1	CTRP2	7.2543	13.5516	2.4616	7.2119
Tm87-16	CTRP2	7.3193	13.9274	2.3258	7.6464
SK-UT-1	CTRP2	7.3283	8.9457	4.5178	0.2155
RD	CTRP2	9.1932	17.9593	1.6297	7.8279

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	7.136	8.6842	4.5381	0.2352

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
2004	CTRP2	7.9181	9.7491	4.4537	0.1737
TOV-21G	CTRP2	-0.3315	1.4878	-0.5909	13.9693
SNU-119	CTRP2	1.5293	9.077	-0.3313	29.6532
OVCAR-4	CTRP2; CTRP1	2.8794	6.4054	2.2136	16.9465
JHOS-4	CTRP1	3.325	5.6202	2.9883	27.2694
RMUG-S	CTRP1	3.3655	6.1152	2.844	28.0457
OVKATE	CTRP1	3.8614	5.0787	3.7466	17.9688
OV-90	CTRP2; CTRP1	4.0787	5.9591	3.6573	8.097
OVMANA	CTRP1	4.173	5.8312	3.8097	15.5554
Caov-3	CTRP2; CTRP1	4.1875	4.8989	4.1464	5.9406
A2780	CTRP1	4.1897	5.3479	4.0182	13.7413
JHOM-1	CTRP2; CTRP1	4.2312	5.1427	4.1314	5.8612
OVK18	CTRP2; CTRP1	4.3734	5.2641	4.2462	5.0187
OVCAR-8	CTRP2; CTRP1	4.5913	6.1962	4.0654	5.1709
OAW42	CTRP2; CTRP1	4.7142	6.0835	4.237	4.1788
TOV-112D	CTRP2	4.7937	7.0431	3.8292	5.6134
RMG-I	CTRP2; CTRP1	4.8094	9.9946	2.3801	11.7093
JHOC-5	CTRP2; CTRP1	4.89	6.123	4.3803	3.1931
IGROV-1	CTRP2; CTRP1	4.9321	7.4025	3.7798	5.6207
SNU-840	CTRP2; CTRP1	4.9404	8.0241	3.4764	6.8769
TYK-nu	CTRP2; CTRP1	5.0052	8.251	3.4179	6.9948
SK-OV-3	CTRP2; CTRP1	5.0346	6.693	4.2215	3.5634
HEY A8	CTRP2; CTRP1	5.1488	6.9943	4.165	3.5838
OC 314	CTRP2	5.1963	7.5919	3.8949	4.5466
EFO-21	CTRP2; CTRP1	5.2208	6.693	4.3725	2.5846
OVCAR-5	CTRP2	5.2605	7.9498	3.7676	4.964
COV318	CTRP1	5.3925	6.3104	4.6845	2.2171
EFO-27	CTRP2; CTRP1	5.5063	7.054	4.4051	1.9932
OV7	CTRP2; CTRP1	5.6099	9.3623	3.3474	6.1909
COV434	CTRP2; CTRP1	6.2265	14.745	1.1512	13.8986
SNU-8	CTRP2	6.4414	7.7304	4.6113	0.3455
JHOS-2	CTRP2	6.4984	8.1215	3.5615	0.1972
OV56	CTRP2	6.5255	7.4531	4.7455	0.083
OVSAHO	CTRP2	6.6364	8.0286	3.6426	0.08
OVISE	CTRP2	6.6683	8.2888	4.4935	0.5154
COV644	CTRP2; CTRP1	6.8298	11.6616	3.0911	5.4005
DOV13	CTRP2	6.9137	8.2995	4.5911	0.2115
ES2	CTRP2	6.9764	8.1619	4.6629	0.0988
FU-OV-1	CTRP2	7.0629	9.4459	4.2114	1.0444
ONCO-DG-1	CTRP2	7.1334	8.816	4.489	0.323
OAW28	CTRP2	7.2078	10.6297	3.782	2.3092
Kuramochi	CTRP2	7.3798	9.9709	4.1483	1.0156
COV362	CTRP2; CTRP1	7.4025	16.5223	1.1435	12.018
MCAS	CTRP2	7.5307	9.0784	4.5459	0.1356
OVTOKO	CTRP2	7.7284	9.9699	4.3012	0.4726

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MSTO-211H	CTRP2; CTRP1	0.7127	3.3068	0.6546	29.1219
NCI-H2052	CTRP2; CTRP1	4.338	5.8314	3.9804	6.143
NCI-H28	CTRP2; CTRP1	5.2423	10.9904	2.2445	11.4174
NCI-H2452	CTRP2	5.7818	8.7928	2.9518	2.4863
MPP 89	CTRP2	7.2431	8.7444	4.5572	0.1787
ACC-MESO-1	CTRP2	7.3347	8.4358	4.6945	0.0344
IST-Mes1	CTRP2	7.3364	12.2	3.1483	4.4751
JL-1	CTRP2	11.0362	21.0685	1.303	6.9472

Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
PaCa-3	CTRP2; CTRP1	3.6963	6.8415	2.8773	12.1783
LNCaP clone FGC	CTRP2	4.7951	8.5996	3.055	8.8535
DU145	CTRP2	4.8733	8.7055	3.0694	8.6357
NCI-H660	CTRP2	5.1967	7.7761	3.8033	4.9302
VCaP	CTRP2	5.3439	9.4809	2.3524	5.5448
22Rv1	CTRP2	7.0898	13.4454	2.402	7.6713

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-15	CTRP2	3.7882	8.6012	2.1349	14.8644
A-253	CTRP2	4.5058	8.734	2.7335	10.7987

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HGC-27	CTRP2	2.692	5.0857	2.4657	16.4649
NUGC-4	CTRP2; CTRP1	2.9878	6.888	2.1285	16.9791
SNU-16	CTRP2	2.9882	4.3116	2.9498	13.8283
ECC10	CTRP2	3.0357	4.2691	3.0053	13.4849
IM95	CTRP2	3.1439	10.5208	0.5966	22.2726
NCC-StC-K140	CTRP2	3.5087	5.9876	3.0417	11.9463
HuG1-N	CTRP2	3.5663	9.3848	0.9928	14.8933
Fu97	CTRP2; CTRP1	3.7654	16.1161	-1.5815	27.3656
NCI-N87	CTRP2	3.8622	11.2531	0.9071	19.4511
AGS	CTRP2; CTRP1	3.9977	4.7979	3.9602	7.1911
SNU-719	CTRP2	4.529	8.0427	1.6549	4.1084
MKN7	CTRP2; CTRP1	4.5808	7.3799	3.4793	7.6163
Hs 746.T	CTRP2	4.5872	6.0548	4.1214	4.8627
SNU-5	CTRP2	4.7042	10.0618	2.2468	12.3931
MKN74	CTRP2; CTRP1	4.9268	9.0995	2.9275	9.2033
SNU-216	CTRP2	5.169	18.2787	-1.4692	24.1122
MKN1	CTRP2	5.4171	7.494	4.1146	3.2451
KE-39	CTRP2	5.5579	10.0105	2.9753	7.749
SNU-620	CTRP2	5.8823	7.3272	4.5025	1.0803
GSU	CTRP2	5.9446	6.6284	4.8202	0.1118
SNU-1	CTRP2	6.2842	8.0222	4.4176	0.9984
KATO III	CTRP2	6.4646	10.9908	3.1553	5.5768
SH-10-TC	CTRP2; CTRP1	6.4793	8.9637	4.1247	1.8854
MKN45	CTRP2	6.583	7.6385	4.7017	0.1275
ECC12	CTRP2	7.0431	8.4077	4.6016	0.1624
SNU-601	CTRP2	7.074	8.9679	4.4069	0.5208
SNU-668	CTRP2	7.1614	8.1931	4.7163	0.0343
NUGC-3	CTRP2	7.537	8.9784	4.5824	0.0967
23132/87	CTRP2	7.5945	8.9302	4.6185	0.0606
GSS	CTRP2	7.759	36.591	-8.5276	31.8823
LMSU	CTRP2	9.2219	18.0744	0.7676	6.8243
SNG-M	CTRP2; CTRP1	4.9141	6.6615	4.134	4.1724
SNU-685	CTRP2	7.2483	8.4668	4.6548	0.0688
SNU-1077	CTRP2	7.4533	9.0127	4.5406	0.1561

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW579	CTRP2	5.0559	9.0298	3.0612	8.3108
BHT-101	CTRP2	5.495	10.3502	2.757	8.7661
FTC-133	CTRP2	5.9626	11.6864	2.4541	9.2007
8505C	CTRP2	6.1667	8.6723	4.0586	2.4125
ML-1 [Human leukemia]	CTRP2	6.3466	8.2235	3.4656	0.417
TT	CTRP2	6.6506	11.9629	2.815	6.6703
FTC-238	CTRP2	6.9734	12.5811	2.737	6.524
CGTH-W-1	CTRP2	7.1239	8.6004	4.5635	0.1984
B-CPAP	CTRP2	7.1345	8.7144	4.5266	0.2549
TT2609-C02	CTRP2	7.3888	15.1238	1.7994	9.5548
8305C	CTRP2	7.4136	9.0615	4.5088	0.2079

Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-1214	CTRP2	1.0616	4.4099	0.8532	27.2448
YD-10B	CTRP2	3.7163	7.5584	2.0338	10.01
PE/CA-PJ34 (clone C12)	CTRP2	3.9811	7.1239	3.0251	10.7901
SNU-899	CTRP2	4.0715	7.8657	2.1851	8.5701
FaDu	CTRP2	4.0931	6.9379	3.2224	9.7166
HSC-2	CTRP2; CTRP1	4.1717	5.3201	4.0086	6.4896
SCC-9	CTRP2; CTRP1	4.9058	6.3486	4.2824	3.5686
PE/CA-PJ49	CTRP2	5.3671	8.19	3.7318	4.9248
PE/CA-PJ15	CTRP2	5.3836	8.4853	3.5978	5.4566
HSC-3	CTRP2	5.7113	6.885	3.7046	0.1776
SCC-4	CTRP2	5.9345	8.4864	3.9967	2.9531
BICR 22	CTRP2	6.0497	7.5243	3.6045	0.2499
CAL-33	CTRP2	6.051	10.1688	3.2649	5.744
SCC-25	CTRP2	6.0745	14.6443	1.0736	14.3837
Detroit 562	CTRP2	6.136	7.7388	3.5602	0.304
BICR 18	CTRP2	6.2007	8.1785	3.4215	0.5848
BHY	CTRP2	6.3016	10.883	3.0948	6.0572
BICR 16	CTRP2	6.4063	8.3273	4.3509	1.1132
PE/CA-PJ41 (clone D2)	CTRP2	6.4629	12.4891	2.4278	8.4983
HSC-4	CTRP2	6.8193	9.4803	4.0726	1.6763
BICR 6	CTRP2	6.8276	8.283	4.5632	0.2892
CAL-27	CTRP2	6.8448	8.0002	4.6714	0.1123
SNU-1076	CTRP2	7.0256	8.0893	4.7048	0.0534
YD-8	CTRP2	7.1188	9.1581	4.3527	0.6285
BICR 31	CTRP2	7.1611	21.542	-2.2296	19.3354
BICR 56	CTRP2	7.2851	8.7536	4.5695	0.1531
SNU-1041	CTRP2	9.1382	16.0432	2.4657	4.986
SNU-1066	CTRP2	10.8733	22.6531	0.4931	9.6523

Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-BLC1	CTRP2	1.333	2.3722	1.3326	24.7274
RT-4	CTRP2; CTRP1	2.3782	5.3669	2.0438	19.0219
5637	CTRP2; CTRP1	3.8023	5.215	3.642	8.9302
KMBC-2	CTRP2; CTRP1	4.352	5.4357	4.1596	5.4072
253J	CTRP2	4.5382	6.9115	3.6615	6.8697
HT-1376	CTRP2; CTRP1	4.5529	6.6211	3.8244	6.2498
BC-3C	CTRP2	4.7163	7.9736	3.2981	7.9986
UM-UC-3	CTRP2; CTRP1	4.9281	6.5583	4.1976	3.8774
253J-BV	CTRP2	5.0671	8.2829	3.444	6.6829
UM-UC-1	CTRP2	5.3017	8.4464	3.5527	5.7905
BFTC-905	CTRP2	5.6281	7.9213	4.0586	3.1435
CAL-29	CTRP2	6.2798	8.6158	4.1529	1.9281
TCCSUP	CTRP2	6.4902	8.2754	4.4155	0.8438
639V	CTRP2	6.5082	7.7721	4.6236	0.2895
KU-19-19	CTRP2	6.6222	7.6987	4.6951	0.1278
647V	CTRP2	6.8189	8.1418	4.6115	0.2052
JMSU-1	CTRP2	6.8914	8.1957	4.6199	0.1723
SW1710	CTRP2	7.0898	8.9765	4.4105	0.5053
RT-112	CTRP2	7.5119	9.1311	4.5207	0.1696
T24	CTRP2	7.7225	14.5203	2.3092	7.1713
VM-CUB-1	CTRP2	7.9034	9.3814	4.5734	0.0635
J82	CTRP2	8.2038	12.4604	3.5207	2.3063
SCaBER	CTRP2	10.0921	19.1696	1.6129	6.895

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HeLa	CTRP2	6.5022	7.4551	4.7363	0.0985

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