Details of the Drug

General Information of Drug (ID: DMB5JWX)

Drug Name
Pegadricase
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 304.34
Logarithm of the Partition Coefficient (xlogp) -3.4
Rotatable Bond Count (rotbonds) 13
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C13H24N2O6
IUPAC Name
(2S)-2-amino-6-[[4-(2-methoxyethoxy)-4-oxobutanoyl]amino]hexanoic acid
Canonical SMILES
COCCOC(=O)CCC(=O)NCCCC[C@@H](C(=O)O)N
InChI
InChI=1S/C13H24N2O6/c1-20-8-9-21-12(17)6-5-11(16)15-7-3-2-4-10(14)13(18)19/h10H,2-9,14H2,1H3,(H,15,16)(H,18,19)/t10-/m0/s1
InChIKey
PNFORBBPPMQASU-JTQLQIEISA-N
Cross-matching ID
PubChem CID
86278331
CAS Number
1040753-26-1
UNII
50XB37EKN8
DrugBank ID
DB15129
TTD ID
D0S3BF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Uric acid (URA) TTZ1SWF NOUNIPROTAC Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018169)
2 Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J Rheumatol. 2002 Sep;29(9):1942-9.