Details of the Drug

General Information of Drug (ID: DMBEA6V)

Drug Name
AZD1208
Synonyms
AZD1208; 1204144-28-4; AZD-1208; UNII-S98NFM1378; (R,Z)-5-((2-(3-aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione; CHEMBL2048872; S98NFM1378; AZD 1208; AK174910; GTPL7698; (5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione; (5Z)-5-({2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl}methylidene)-1,3-thiazolidine-2,4-dione; SCHEMBL1580644; MolPort-035-395-904; EX-A1804; AOB87151; s7104; 2236AH; ZINC84670255; BDBM50387298; AKOS025404917; CS-1668; QC-11435; HY-15604
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 379.5
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C21H21N3O2S
IUPAC Name
(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione
Canonical SMILES
C1C[C@H](CN(C1)C2=C(C=CC=C2C3=CC=CC=C3)/C=C\\4/C(=O)NC(=O)S4)N
InChI
InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
InChIKey
MCUJKPPARUPFJM-UWCCDQBKSA-N
Cross-matching ID
PubChem CID
58423153
CAS Number
1204144-28-4
TTD ID
D00IFR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase pim-2 (PIM2) TT69J2Z PIM2_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase pim-2 (PIM2) DTT PIM2 6.70E-03 0.59 1.1
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.6616 7.2813 -0.1681 31.6181
EW-3 GDSC1; GDSC2 3.7586 11.1439 -0.2314 19.7662
SK-PN-DW GDSC1; GDSC2 3.9606 9.3894 0.8026 13.8512
EW-22 GDSC1; GDSC2 4.2834 8.4736 1.4968 8.9804
ES6 GDSC1; GDSC2 4.3198 7.1166 2.1779 4.802
A-673 GDSC1; GDSC2 4.3456 7.0042 2.248 4.3344
CHSA8926 GDSC1; GDSC2 4.3906 7.2958 2.1394 4.8871
EW-7 GDSC1; GDSC2 4.5094 9.5688 1.1244 10.6367
CHSA0108 GDSC1 4.6351 7.044 2.4079 3.6122
CAL-78 GDSC2 4.65 8.6968 1.6445 7.283
TC-71 GDSC1; GDSC2 4.6555 7.0569 2.4139 2.8362
SJSA-1 GDSC1 4.7509 7.1478 2.4277 3.2554
SK-ES-1 GDSC1; GDSC2 4.7664 10.6909 0.7609 12.0763
EW-13 GDSC1; GDSC2 4.7836 10.9828 0.6307 12.7416
EW-18 GDSC1; GDSC2 4.7928 7.8161 2.1502 4.0723
HuO9 GDSC1; GDSC2 4.8036 8.3348 1.9164 5.3876
ES1 GDSC1 4.9144 10.3191 1.0451 12.3265
EW-24 GDSC1; GDSC2 4.9952 9.4698 1.5057 7.3803
ES5 GDSC1; GDSC2 5.1397 14.7912 -0.9773 19.4538
ES7 GDSC1; GDSC2 5.1969 8.0224 2.289 2.6985
HOS GDSC1; GDSC2 5.2043 6.8271 2.7816 0.558
ES4 GDSC1; GDSC2 5.2375 7.4772 2.5404 1.4537
CHSA0011 GDSC1 5.3294 9.147 1.8635 5.8777
ES8 GDSC1; GDSC2 5.4161 7.3438 2.6744 0.7741
MHH-ES-1 GDSC1; GDSC2 5.4998 12.8625 0.222 13.2406
CAL-72 GDSC1; GDSC2 5.5523 12.0712 0.6374 11.0174
EW-11 GDSC1; GDSC2 5.5613 8.4555 2.2938 2.2165
H-EMC-SS GDSC1; GDSC2 5.5782 11.325 1.0082 8.9971
HuO-3N1 GDSC1; GDSC2 5.6096 9.5164 1.8594 4.3336
U2OS GDSC1; GDSC2 5.7204 10.5505 1.457 6.3084
G-292 clone A141B1 GDSC1; GDSC2 5.7215 7.4297 2.7655 0.3483
CADO-ES1 GDSC1; GDSC2 5.8562 7.4071 2.823 0.1928
EW-16 GDSC1; GDSC2 5.9436 8.8019 2.3363 1.6324
MG-63 GDSC1; GDSC2 5.9449 12.0566 0.899 8.8805
EW-1 GDSC1; GDSC2 6.1074 8.366 2.5758 0.6645
NY GDSC1; GDSC2 6.2473 8.4588 2.5971 0.5375
SaOS-2 GDSC1; GDSC2 6.349 15.1819 -0.3146 14.0058
NOS-1 [Human HNSCC] GDSC1; GDSC2 6.3586 16.3879 -0.8862 16.4221
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 160 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.9357 9.6696 -0.1792 25.9756
MOLM-16 GDSC1 -4.713 -0.1512 -4.7979 82.7645
JeKo-1 GDSC1 1.5326 13.1004 -3.1283 40.1058
Ku812 GDSC1; GDSC2 1.9782 11.1323 -1.7528 31.2916
NB4 GDSC1 2.0707 4.9286 1.3322 20.812
WSU-DLCL2 GDSC1 2.7416 3.8841 2.4796 9.0953
EoL-1 GDSC1; GDSC2 2.9387 10.3882 -0.5355 23.6023
CTV-1 GDSC1; GDSC2 3.0082 5.4255 1.9985 9.3365
MV4-11 GDSC1; GDSC2 3.0472 9.4655 0.0183 20.6856
SUP-M2 GDSC1; GDSC2 3.1245 4.9525 2.3368 6.8361
CTB-1 GDSC1 3.1831 7.7957 0.9683 18.4581
Reh GDSC1; GDSC2 3.2064 4.6625 2.5531 5.2147
RL GDSC1 3.2211 6.018 1.889 11.6394
RPMI-8226 GDSC1; GDSC2 3.2662 6.6864 1.593 11.0829
HH [Human lymphoma] GDSC1; GDSC2 3.3018 7.5869 1.1726 13.5479
U-698-M GDSC1; GDSC2 3.334 7.3736 1.3061 12.6471
EM-2 GDSC1; GDSC2 3.3629 8.4955 0.7692 15.7223
ALL-SIL GDSC1; GDSC2 3.3686 9.0982 0.4726 17.3482
EHEB GDSC1 3.3749 6.3573 1.8481 11.388
A3/Kawakami GDSC1; GDSC2 3.399 6.8403 1.6266 10.4862
NCI-H929 GDSC1; GDSC2 3.4473 7.0444 1.5641 10.7357
L-363 GDSC1; GDSC2 3.4799 7.2062 1.5098 10.9792
AMO1 GDSC1; GDSC2 3.481 6.0789 2.0736 7.451
L-540 GDSC1; GDSC2 3.5227 7.5094 1.3931 11.5742
VL51 GDSC1; GDSC2 3.5657 6.2243 2.0686 7.2521
SU-DHL-5 GDSC1; GDSC2 3.5992 5.0128 2.6949 3.2327
OCI-AML-5 GDSC1; GDSC2 3.6046 6.8998 1.7627 9.0643
SUP-HD1 GDSC1; GDSC2 3.6119 7.4473 1.4957 10.6978
PL-21 GDSC1 3.6555 9.7136 0.3996 20.2294
A4/Fukuda GDSC1; GDSC2 3.6589 6.9597 1.7756 8.8377
Karpas-620 GDSC1; GDSC2 3.6636 6.8292 1.8442 8.3976
CML-T1 GDSC1; GDSC2 3.6702 7.3595 1.5855 9.986
MOLT-16 GDSC1; GDSC2 3.6839 5.4874 2.5241 4.0914
BV-173 GDSC1; GDSC2 3.687 6.5743 1.989 7.4305
ALL-PO GDSC1; GDSC2 3.7109 6.1826 2.2014 6.0401
ML-2 GDSC1; GDSC2 3.7117 5.4121 2.5812 3.671
Loucy GDSC1; GDSC2 3.7128 6.1218 2.2329 5.8382
JURL-MK1 GDSC1; GDSC2 3.7182 11.147 -0.2654 20.0394
DND-41 GDSC1; GDSC2 3.753 5.3309 2.6501 3.1522
MC116 GDSC1 3.7767 6.6386 2.0257 8.6651
CRO-AP2 GDSC1 3.7837 7.8015 1.4544 12.9167
CCRF-CEM GDSC1; GDSC2 3.7854 5.7079 2.4897 4.0649
Daudi GDSC1; GDSC2 3.7951 6.5662 2.0753 6.6164
SCC-3 GDSC2 3.7999 6.0553 2.3302 5.0183
Jurkat GDSC1; GDSC2 3.8339 6.8338 1.9723 7.1611
GA-10 GDSC1; GDSC2 3.8443 7.6442 1.5792 9.5656
OCI-Ly19 GDSC1 3.8557 6.1159 2.3409 6.0014
MN-60 GDSC1; GDSC2 3.8672 6.1612 2.3271 4.8788
MOLT-13 GDSC1; GDSC2 3.8723 6.7185 2.0576 6.5361
RCH-ACV GDSC1 3.8732 6.3517 2.2383 6.738
OCI-AML-2 GDSC1; GDSC2 3.8889 9.352 0.7654 14.2531
KMS-11 GDSC1 3.9515 7.6229 1.671 10.7918
JVM-3 GDSC1; GDSC2 3.9601 7.5353 1.7206 8.4037
RPMI-8402 GDSC1 3.9835 7.519 1.746 10.136
SR GDSC1; GDSC2 4.0172 7.5814 1.7402 8.1432
MOLP-8 GDSC1; GDSC2 4.0489 11.5229 -0.1896 18.7657
Jiyoye GDSC1; GDSC2 4.0654 6.7663 2.1731 5.3733
SU-DHL-16 GDSC1 4.0689 6.5829 2.2641 5.9872
MOLM-13 GDSC1; GDSC2 4.0783 9.2616 0.9565 12.6664
NOMO-1 GDSC1; GDSC2 4.0889 5.5918 2.7446 1.9359
Karpas-299 GDSC1 4.0969 8.7217 1.2376 13.4327
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.0995 9.8292 0.6915 14.1048
ATN-1 GDSC1; GDSC2 4.1233 6.6668 2.261 4.7127
BC-1 GDSC1; GDSC2 4.1261 6.7889 2.2042 5.0505
P30/OHK GDSC1; GDSC2 4.1276 9.7125 0.7708 13.5908
HC-1 GDSC1; GDSC2 4.1295 7.5534 1.8357 7.2906
MHH-PREB-1 GDSC1; GDSC2 4.1444 6.4528 2.3775 3.9682
697 GDSC1; GDSC2 4.1677 10.3866 0.4673 15.1431
RPMI-6666 GDSC1; GDSC2 4.1967 6.5808 2.3512 4.0192
EJM GDSC1; GDSC2 4.2106 8.195 1.5804 8.6501
Mono-Mac-6 GDSC1 4.2174 15.9821 -2.2782 29.3929
ST486 GDSC1; GDSC2 4.2284 6.7938 2.2709 4.4337
P32/ISH GDSC1; GDSC2 4.236 6.5404 2.3957 3.6779
HDLM-2 GDSC1; GDSC2 4.2387 11.3016 0.068 17.0119
HAL-01 GDSC1; GDSC2 4.2602 12.9525 -0.7355 20.6424
HT GDSC1 4.3109 8.772 1.3707 11.8543
Karpas-422 GDSC1; GDSC2 4.344 7.5333 1.9951 5.8456
U266B1 GDSC1; GDSC2 4.3566 7.6932 1.9269 6.2282
VAL GDSC1; GDSC2 4.3699 8.7716 1.4134 9.2741
H9 GDSC1; GDSC2 4.3832 7.3521 2.1078 5.0898
K-562 GDSC1; GDSC2 4.4093 7.2366 2.1797 4.612
GDM-1 GDSC1; GDSC2 4.4281 11.1221 0.301 15.345
DB GDSC1; GDSC2 4.4298 11.4211 0.1545 16.0863
SUP-B8 GDSC1 4.4338 10.3147 0.7033 15.8642
LAMA-84 GDSC1; GDSC2 4.4423 6.7072 2.4468 3.0059
YT GDSC1 4.4667 8.2606 1.7293 8.8623
JVM-2 GDSC1; GDSC2 4.4975 8.1999 1.7794 6.8083
KG-1 GDSC2 4.4979 6.5916 2.532 2.4428
L-428 GDSC1; GDSC2 4.5045 6.6301 2.5185 2.5057
PF-382 GDSC1; GDSC2 4.5065 6.7914 2.4468 2.8976
HL-60 GDSC1; GDSC2 4.5641 6.1727 2.7503 1.2364
MLMA GDSC1; GDSC2 4.601 10.2485 0.8581 11.9285
SKM-1 GDSC1; GDSC2 4.6167 13.007 -0.4884 18.6554
DoHH2 GDSC2 4.6431 6.2993 2.7368 1.2087
BL-41 GDSC1; GDSC2 4.6707 6.104 2.8298 0.7797
CMK GDSC1 4.7005 9.9824 1.0589 12.8292
HEL GDSC1; GDSC2 4.7354 13.0818 -0.4359 18.1256
QIMR-WIL GDSC1 4.7445 9.0335 1.547 9.4127
IM-9 GDSC1; GDSC2 4.7607 6.3942 2.7548 1.0061
JSC-1 GDSC1; GDSC2 4.7686 7.6679 2.2035 3.8145
KOPN-8 GDSC1; GDSC2 4.7722 6.8197 2.5826 1.7895
JJN-3 GDSC1; GDSC2 4.7833 6.5014 2.7218 1.1259
Namalwa GDSC1; GDSC2 4.8211 6.4668 2.7538 0.9526
Sc-1 GDSC1 4.8288 13.8829 -0.7614 22.2535
SK-MM-2 GDSC1; GDSC2 4.8347 7.4392 2.3454 2.9275
LC4-1 GDSC1; GDSC2 4.8451 7.2759 2.4236 2.4981
WSU-NHL GDSC1; GDSC2 4.8547 6.5473 2.737 0.9908
TUR GDSC1; GDSC2 4.8593 7.2655 2.436 2.4134
MEG-01 GDSC1; GDSC2 4.863 7.675 2.256 3.3676
ME1 GDSC1; GDSC2 4.8668 8.3296 1.9585 5.0284
SU-DHL-10 GDSC1; GDSC2 4.8779 5.8534 3.0075 0.132
NKM-1 GDSC1 4.8843 7.6185 2.2936 3.8926
KMS-12-BM GDSC2 4.8952 6.5946 2.7368 0.9539
OCI-AML-3 GDSC1; GDSC2 4.908 6.2972 2.8585 0.4963
Karpas-1106P GDSC1; GDSC2 4.9257 6.8009 2.6675 1.2173
SU-DHL-6 GDSC1; GDSC2 4.9476 6.8 2.6784 1.1484
KY821 GDSC1; GDSC2 4.9675 11.5875 0.4673 13.1799
Hs 445 GDSC1; GDSC2 4.9777 7.1873 2.5323 1.7786
OCI-M1 GDSC1; GDSC2 4.988 6.2132 2.9215 0.2752
Ramos.2G6.4C10 GDSC1; GDSC2 4.995 7.0535 2.5971 1.4572
DEL GDSC1; GDSC2 5.0032 6.0359 2.9896 0.13
KE-37 GDSC1; GDSC2 5.009 6.0145 2.999 0.1137
SU-DHL-4 GDSC1 5.0118 6.1617 2.9489 0.254
P31/FUJ GDSC1 5.0209 6.3383 2.889 0.4282
Karpas-231 GDSC1; GDSC2 5.1102 6.5216 2.8571 0.3865
SU-DHL-8 GDSC1; GDSC2 5.112 6.3577 2.917 0.237
THP-1 GDSC1 5.1347 13.486 -0.3399 19.4757
NU-DUL-1 GDSC1 5.1642 6.4698 2.8968 0.3272
CESS GDSC1; GDSC2 5.1711 7.025 2.6912 0.897
OPM-2 GDSC1; GDSC2 5.1748 6.7187 2.8102 0.4874
KM-H2 GDSC1; GDSC2 5.1788 9.6682 1.5306 6.8801
CA46 GDSC1; GDSC2 5.1831 7.6883 2.4253 2.0425
ROS-50 GDSC1 5.2011 8.9339 1.8843 6.006
Karpas-45 GDSC1; GDSC2 5.2077 7.6415 2.4576 1.8605
MOLT-4 GDSC1; GDSC2 5.2133 6.9754 2.729 0.7273
DG-75 GDSC1; GDSC2 5.2194 11.0003 0.9257 10.1717
KCL-22 GDSC1; GDSC2 5.3072 6.9157 2.7906 0.4724
RS4;11 GDSC1; GDSC2 5.3104 11.2334 0.8755 10.2538
OCI-Ly7 GDSC1 5.3203 6.6705 2.8842 0.2916
SUP-T1 GDSC1; GDSC2 5.3241 7.618 2.5242 1.4363
P12-Ichikawa GDSC1; GDSC2 5.3554 6.6819 2.8932 0.2051
Raji GDSC1; GDSC2 5.3573 12.1277 0.4782 12.2543
LP-1 GDSC1; GDSC2 5.3936 7.067 2.7694 0.4875
NALM-6 GDSC1; GDSC2 5.4367 7.1993 2.7376 0.557
SUP-B15 GDSC2 5.4731 6.9651 2.8371 0.2809
BE-13 GDSC1; GDSC2 5.4792 7.3462 2.7 0.6481
Granta-519 GDSC1; GDSC2 5.5475 7.3826 2.7144 0.5641
Kasumi-1 GDSC1; GDSC2 5.5673 12.6757 0.3582 12.4169
MM1.S GDSC2 5.58 7.1356 2.8168 0.2867
RPMI-8866 GDSC2 5.5881 7.2734 2.7705 0.391
ARH-77 GDSC1; GDSC2 5.6137 7.6856 2.6277 0.798
MHH-CALL-2 GDSC1; GDSC2 5.616 7.1367 2.8297 0.248
EB2 GDSC1; GDSC2 5.6361 7.1608 2.8287 0.2437
BALL-1 GDSC1; GDSC2 5.6796 7.3746 2.7693 0.356
GR-ST GDSC1; GDSC2 5.9028 8.1195 2.5843 0.7552
WIL2 NS GDSC1; GDSC2 5.9081 7.3472 2.8617 0.1255
Farage GDSC1; GDSC2 5.9693 7.3335 2.8872 0.087
KMOE-2 GDSC1; GDSC2 6.0713 8.2605 2.6003 0.6139
L-1236 GDSC1; GDSC2 6.1421 8.4785 2.548 0.7268
RC-K8 GDSC1; GDSC2 6.2461 7.3561 2.971 0.0155
⏷ Show the Full List of 160 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC1; GDSC2 3.6011 5.7498 2.3321 5.5006
ESO-26 GDSC1; GDSC2 4.0013 5.5651 2.7033 2.326
HCE-4 GDSC1 4.1499 8.0133 1.6253 10.5193
KYAE-1 GDSC1; GDSC2 4.2072 6.4093 2.4389 3.4798
KYSE-50 GDSC1; GDSC2 4.2503 6.3983 2.4714 3.2083
OACP4 C GDSC1; GDSC2 4.8463 7.5207 2.3157 3.0697
ESO-51 GDSC1; GDSC2 5.4202 7.3725 2.6651 0.8033
KYSE-220 GDSC1; GDSC2 5.5131 7.812 2.5341 1.2196
OACM5.1 C GDSC1; GDSC2 6.2498 8.2282 2.6806 0.3431
TE-12 GDSC1; GDSC2 6.2839 9.4068 2.251 1.671
SK-GT-4 GDSC1; GDSC2 6.5671 8.6963 2.6334 0.3357
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.7029 8.4719 1.7869 6.3379
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-17 GDSC1 2.4329 11.244 -1.4024 32.7485
Kelly GDSC1; GDSC2 3.5505 13.8204 -1.738 26.3596
KP-N-YN GDSC1; GDSC2 3.7727 7.9071 1.3933 10.8873
CHP-134 GDSC2 3.8222 9.2749 0.7514 14.5135
SK-N-SH GDSC1 3.9675 15.7127 -2.344 30.3076
SK-N-MC-IXC GDSC1 4.0482 6.7505 2.1687 6.7647
SK-N-BE(2)-M17 GDSC1; GDSC2 4.1366 6.7623 2.2242 4.9067
SJNB-14 GDSC1; GDSC2 4.1993 7.1669 2.0724 5.6903
SJNB-5 GDSC1 4.2195 8.3499 1.5111 11.1352
SJNB-10 GDSC1; GDSC2 4.3959 11.0833 0.2958 15.4533
SJNB-13 GDSC1; GDSC2 4.5062 11.5487 0.149 15.9206
IMR-5 GDSC1; GDSC2 4.6447 8.87 1.5578 7.8043
SJNB-12 GDSC1 4.7582 7.9701 2.0579 5.7819
SK-N-DZ GDSC1; GDSC2 4.7921 16.566 -2.1183 24.3851
SiMa GDSC1; GDSC2 4.798 9.3449 1.4341 8.1991
CHP-126 GDSC1 4.8824 16.3238 -1.9287 26.462
GOTO GDSC1; GDSC2 4.9167 7.5587 2.3386 2.8403
NH-12 GDSC1; GDSC2 4.9503 15.5301 -1.4839 21.8446
NB69 GDSC1; GDSC2 5.0633 12.3108 0.1831 14.408
CHP-212 GDSC2 5.2683 13.3392 -0.1718 15.6507
NB(TU)1 GDSC1; GDSC2 5.3055 7.1291 2.7095 0.7301
SK-N-FI GDSC1 5.326 17.6696 -2.2579 26.325
TGW GDSC1; GDSC2 5.3702 7.152 2.7281 0.6261
LA-N-6 GDSC1 5.3743 7.4219 2.6259 1.221
SJNB-7 GDSC1; GDSC2 5.5078 7.048 2.8207 0.3045
SK-N-AS GDSC1; GDSC2 5.5973 7.0119 2.8663 0.1858
SJNB-6 GDSC1 5.8668 7.497 2.7957 0.2956
GI-ME-N GDSC1; GDSC2 6.01 15.7443 -0.8167 16.8583
NB1 GDSC1 6.7228 17.6776 -1.2575 19.4687
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.1769 6.89 2.7462 0.693
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1; GDSC2 3.0862 5.8441 1.8594 9.9639
EFM-192A GDSC1; GDSC2 3.8194 5.6954 2.5199 3.801
HCC70 GDSC1; GDSC2 3.9723 6.9779 2.0035 6.6301
MDA-MB-415 GDSC1; GDSC2 4.1317 9.3831 0.9369 12.6411
UACC-893 GDSC1 4.1618 8.5811 1.3553 12.4131
MCF-7 GDSC1; GDSC2 4.3065 7.2492 2.1058 5.26
BT-483 GDSC1 4.3241 8.8803 1.3273 12.1172
Evsa-T GDSC1; GDSC2 4.3369 8.1178 1.7082 7.5874
HCC1419 GDSC1; GDSC2 4.3726 8.4067 1.5931 8.1974
HCC1187 GDSC1; GDSC2 4.4746 6.7588 2.4426 2.9746
Hs 578T GDSC1; GDSC2 4.5857 7.9997 1.9338 5.7108
T-47D GDSC1; GDSC2 4.5883 9.5785 1.1759 10.1567
CAL-120 GDSC1; GDSC2 4.5937 9.1958 1.3654 9.0442
CAMA-1 GDSC1; GDSC2 4.5946 6.5676 2.5968 1.9554
BT-474 GDSC1; GDSC2 4.5959 6.4766 2.6371 1.7483
HCC1937 GDSC1; GDSC2 4.6603 7.6635 2.1393 4.3707
HCC2157 GDSC1; GDSC2 4.6954 7.2694 2.3413 3.1701
MDA-MB-361 GDSC1; GDSC2 4.7181 6.5107 2.6859 1.3594
HCC1954 GDSC1; GDSC2 4.7924 7.6152 2.2417 3.5615
BT-20 GDSC1; GDSC2 4.8236 6.8111 2.6128 1.58
HCC1806 GDSC1; GDSC2 4.825 8.7073 1.7552 6.2795
CAL-51 GDSC1; GDSC2 4.8585 6.7858 2.641 1.4078
AU565 GDSC1; GDSC2 4.9771 8.07 2.1443 3.795
HCC2218 GDSC1 4.9911 7.3883 2.4535 2.6714
HCC1500 GDSC1; GDSC2 4.9979 6.7032 2.7404 0.8506
HCC38 GDSC1; GDSC2 5.042 10.4108 1.0883 9.6495
HDQ-P1 GDSC1; GDSC2 5.0759 9.8023 1.401 7.8157
EFM-19 GDSC1; GDSC2 5.1498 11.3963 0.6879 11.6056
HCC202 GDSC1 5.1695 7.8107 2.3659 2.9226
JIMT-1 GDSC1; GDSC2 5.1717 9.9125 1.4113 7.5675
HCC1569 GDSC1; GDSC2 5.2545 10.0849 1.3834 7.5626
MDA-MB-231 GDSC1; GDSC2 5.2565 11.3297 0.793 10.8122
MDA-MB-157 GDSC1; GDSC2 5.2579 7.3549 2.5996 1.1834
MDA-MB-175-VII GDSC1 5.2615 8.0769 2.3 3.1792
MRK-nu-1 GDSC1; GDSC2 5.2927 6.7933 2.8298 0.3722
HCC1395 GDSC1 5.41 8.9255 2.0095 4.7622
HCC1428 GDSC1; GDSC2 5.4258 6.847 2.8612 0.2462
MDA-MB-330 GDSC1; GDSC2 5.4436 7.5132 2.6208 0.9448
ZR-75-30 GDSC1; GDSC2 5.4525 7.192 2.7468 0.5211
MDA-MB-453 GDSC1; GDSC2 5.4722 7.3917 2.6799 0.7177
MFM-223 GDSC1; GDSC2 5.4879 7.0692 2.8056 0.3476
COLO 824 GDSC1; GDSC2 5.5148 12.6523 0.3336 12.652
HCC1599 GDSC1 5.5372 24.7873 -5.6251 33.2298
DU4475 GDSC1; GDSC2 5.659 14.1433 -0.2865 15.3106
BT-549 GDSC1; GDSC2 6.1218 14.7219 -0.2473 14.1601
MDA-MB-436 GDSC1; GDSC2 6.1851 17.9222 -1.7514 20.0442
MDA-MB-468 GDSC1; GDSC2 6.6752 19.7907 -2.3128 20.9167
HCC1143 GDSC1; GDSC2 6.6999 9.2968 2.4693 0.6615
CAL-85-1 GDSC1; GDSC2 6.7463 15.2174 -0.0716 12.1492
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Onda 10 GDSC1 3.4979 5.172 2.5392 5.5646
SK-MG-1 GDSC1; GDSC2 3.5016 5.6508 2.3036 5.9434
8-MG-BA GDSC1; GDSC2 3.7088 5.5961 2.4889 4.2503
M059J GDSC1; GDSC2 3.785 6.4103 2.1446 6.2097
NMC-G1 GDSC1 3.9152 6.5058 2.1933 6.9587
YKG-1 GDSC1 3.9325 9.9648 0.4946 18.7236
GI-1 GDSC1; GDSC2 4.0605 10.2268 0.4641 15.4432
PFSK-1 GDSC1; GDSC2 4.0725 9.3207 0.9228 12.8746
LNZTA3WT4 GDSC1 4.245 7.169 2.1027 6.7217
GaMG GDSC1; GDSC2 4.2601 7.034 2.1775 4.927
D-336MG GDSC1 4.2728 6.9189 2.2408 5.6262
SF126 GDSC1 4.3077 8.0016 1.744 9.196
MOG-G-UVW GDSC1 4.3137 6.5428 2.4439 4.048
SF295 GDSC1 4.4043 5.9778 2.7506 1.7847
YH-13 GDSC1; GDSC2 4.5435 7.7047 2.0458 5.136
Onda 11 GDSC1 4.5987 8.6981 1.6091 9.3638
D-502MG GDSC1 4.6195 11.5225 0.2464 17.9573
D283 Med GDSC1; GDSC2 4.6558 12.561 -0.2385 17.4203
LN-405 GDSC1; GDSC2 4.7126 6.4072 2.7263 1.1806
KNS-42 GDSC1 4.7276 11.5438 0.3156 17.2531
Hs 683 GDSC1 4.7596 11.0749 0.5685 15.7074
KNS-81-FD GDSC1 4.7697 12.0718 0.0871 18.3713
LN-18 GDSC1; GDSC2 4.9001 6.2302 2.8804 0.4322
D-542MG GDSC1 4.9094 6.8253 2.6496 1.6358
U-87MG ATCC GDSC1; GDSC2 4.9798 7.5069 2.3961 2.4505
KINGS-1 GDSC1; GDSC2 4.9958 7.7454 2.3002 2.9257
D-566MG GDSC1 5.0317 7.6977 2.3411 3.3103
A-172 GDSC1; GDSC2 5.0862 10.0512 1.2896 8.4252
MOG-G-CCM GDSC1 5.134 7.6871 2.4004 2.7684
CAS-1 GDSC1; GDSC2 5.1415 6.5018 2.8767 0.3203
KALS-1 GDSC1; GDSC2 5.1472 8.3348 2.1236 3.6372
D-423MG GDSC1 5.1797 24.5835 -5.8031 34.2409
SW1783 GDSC1 5.2286 9.4099 1.6822 7.309
DK-MG GDSC1; GDSC2 5.231 7.423 2.5594 1.3778
H4 GDSC1; GDSC2 5.2453 11.9617 0.4809 12.4843
U-118MG GDSC1; GDSC2 5.2635 7.2118 2.659 0.9444
42-MG-BA GDSC1; GDSC2 5.4291 7.4358 2.6445 0.8697
D-247MG GDSC1 5.4882 8.5242 2.2272 3.2601
D-263MG GDSC1; GDSC2 5.5539 6.927 2.88 0.1738
SF539 GDSC1; GDSC2 5.5791 7.4709 2.6944 0.6062
GB-1 GDSC1; GDSC2 5.58 7.1955 2.7954 0.3345
AM-38 GDSC1; GDSC2 5.6094 7.2806 2.7762 0.3681
T98G GDSC1; GDSC2 5.6419 9.8257 1.7395 4.9201
SF268 GDSC1; GDSC2 5.8018 8.4052 2.4298 1.3823
Daoy GDSC1; GDSC2 5.8777 7.5323 2.7874 0.2495
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 5.9074 8.5789 2.4087 1.3743
U-251MG GDSC1; GDSC2 5.9502 14.051 -0.0419 13.5637
LN-229 GDSC1; GDSC2 5.9837 7.7521 2.7495 0.2905
DBTRG-05MG GDSC1; GDSC2 6.0485 14.3859 -0.1359 13.7999
SW1088 GDSC1; GDSC2 6.0741 8.3419 2.5713 0.6957
SNB-75 GDSC1 6.084 8.4578 2.532 1.0082
Becker GDSC1; GDSC2 6.1248 7.9095 2.7461 0.2545
D-392MG GDSC1; GDSC2 6.3691 8.5255 2.6199 0.4319
ONS-76 GDSC1; GDSC2 6.3971 8.2752 2.7178 0.2318
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 4.8937 6.8925 2.6139 1.8596
ETK-1 GDSC1; GDSC2 5.4145 8.1824 2.3344 2.1975
TGBC24TKB GDSC1; GDSC2 5.6944 7.7495 2.6373 0.7148
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1; GDSC2 3.4921 7.2083 1.5187 10.8897
MFE-319 GDSC1; GDSC2 4.3388 6.3144 2.5642 2.5236
EN GDSC1; GDSC2 5.1368 6.3893 2.9151 0.2322
KLE GDSC1; GDSC2 5.4145 7.6855 2.5394 1.2863
RL95-2 GDSC1; GDSC2 5.4329 7.0795 2.7804 0.4367
MFE-296 GDSC1; GDSC2 5.5543 7.4417 2.6952 0.6183
MFE-280 GDSC1; GDSC2 5.7759 8.1946 2.5013 1.1287
AN3-CA GDSC1; GDSC2 5.8918 13.4511 0.2058 12.4986
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-909 GDSC1; GDSC2 3.8613 7.4375 1.6946 8.8122
KTCTL-13 GDSC1 4.285 7.9907 1.7333 9.3379
LB1047-RCC GDSC1 4.3556 7.7595 1.8943 7.9641
LB2241-RCC GDSC1 4.4674 6.5685 2.5247 3.1521
A-498 GDSC1; GDSC2 4.475 12.6852 -0.4369 18.7843
KTCTL-140 GDSC1 4.596 7.208 2.3101 4.3696
KTCTL-195 GDSC1; GDSC2 4.6323 13.4162 -0.6791 19.4474
786-O GDSC1; GDSC2 4.7211 7.4421 2.2781 3.4779
SN12C GDSC1; GDSC2 4.7982 6.932 2.548 1.9271
A-704 GDSC1; GDSC2 4.83 7.825 2.1685 3.9054
SW13 GDSC1; GDSC2 4.8393 7.1258 2.4861 2.1844
SW156 GDSC1 4.8671 9.1962 1.5512 9.0675
KTCTL-21 GDSC1 4.8794 12.6542 -0.1184 19.113
KTCTL-1M GDSC1 5.0346 7.3757 2.4817 2.4311
Caki-1 GDSC1 5.0426 13.7829 -0.553 20.7247
UO-31 GDSC1 5.1698 8.9121 1.8754 6.1325
HA7-RCC GDSC1; GDSC2 5.2299 8.8687 1.9311 4.5505
OS-RC-2 GDSC1; GDSC2 5.259 7.187 2.6668 0.9186
VMRC-RCZ GDSC1; GDSC2 5.3021 7.0381 2.7427 0.6218
769-P GDSC1; GDSC2 5.3489 7.1346 2.7257 0.647
NCC010 GDSC1; GDSC2 5.5012 7.9217 2.4847 1.432
KMRC-20 GDSC1; GDSC2 5.5117 12.1735 0.5613 11.4967
KTCTL-26A GDSC1 5.5444 7.5925 2.6338 1.0269
KMRC-1 GDSC1 5.5462 11.0837 1.1012 10.3666
BB65-RCC GDSC1 5.5603 7.6051 2.6358 1.0048
RCC10RGB GDSC1; GDSC2 5.5749 13.4962 -0.032 14.3101
TK-10 GDSC1; GDSC2 5.7846 8.2975 2.4647 1.2604
NCC021 GDSC1 6.0095 17.4797 -1.6613 22.6495
RXF 393L GDSC1; GDSC2 6.2296 9.2974 2.2697 1.6441
LB996-RCC GDSC1; GDSC2 7.106 15.6596 -0.0508 11.408
CAL-54 GDSC1; GDSC2 7.1971 18.3579 -1.2634 16.2727
ACHN GDSC1; GDSC2 7.4391 16.2031 -0.0966 11.0407
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO205 GDSC1; GDSC2 4.2605 7.1602 2.1174 5.2869
CaR-1 GDSC1; GDSC2 4.2777 6.6871 2.3536 3.8448
RCM-1 [Human ESC] GDSC1; GDSC2 4.3626 6.5486 2.4713 3.006
RKO GDSC1; GDSC2 4.4356 10.6577 0.5358 14.0926
SNU-1040 GDSC1; GDSC2 4.5933 5.8267 2.9044 0.5566
HT-29 GDSC1; GDSC2 4.612 9.6463 1.1597 10.1949
SW948 GDSC1; GDSC2 4.6984 6.4524 2.7004 1.3145
HT115 GDSC1; GDSC2 4.7024 5.915 2.9172 0.4364
SK-CO-1 GDSC1; GDSC2 4.7287 6.5771 2.6633 1.4532
SW48 GDSC1; GDSC2 4.7378 9.0052 1.5561 7.6167
HCT 116 GDSC1; GDSC2 4.8343 6.8997 2.5807 1.7208
LS123 GDSC1; GDSC2 4.858 15.0633 -1.3229 21.472
NCI-H747 GDSC1; GDSC2 4.9407 8.2342 2.0478 4.3917
KM12 GDSC1; GDSC2 4.958 7.7499 2.277 3.1058
SW1463 GDSC1; GDSC2 4.9622 7.3273 2.4646 2.1286
T84 GDSC1; GDSC2 4.9653 7.5434 2.3723 2.5933
SW1116 GDSC1; GDSC2 5.025 7.6024 2.379 2.4758
LoVo GDSC1; GDSC2 5.0286 14.818 -1.0732 20.0994
LS513 GDSC1; GDSC2 5.067 11.5314 0.5649 12.4416
GP5d GDSC1; GDSC2 5.1822 7.9829 2.2983 2.6714
DiFi GDSC1; GDSC2 5.2009 9.8723 1.449 7.2978
SW1417 GDSC1; GDSC2 5.2517 7.2081 2.6552 0.9684
SNU-407 GDSC1; GDSC2 5.2787 8.7508 2.0127 4.0283
SNU-81 GDSC1; GDSC2 5.3128 7.0918 2.7268 0.6668
SW626 GDSC1; GDSC2 5.316 8.7836 2.0194 3.9345
CW-2 GDSC1; GDSC2 5.3213 7.3194 2.6425 0.9601
C2BBe1 GDSC1; GDSC2 5.3335 7.1435 2.7159 0.6894
SNU-C5 GDSC1; GDSC2 5.3336 7.5373 2.5614 1.2705
LS411N GDSC1; GDSC2 5.339 13.8302 -0.3608 16.358
HCT 15 GDSC1; GDSC2 5.4263 11.4437 0.8525 10.1381
CL-11 GDSC1; GDSC2 5.4352 7.4079 2.6579 0.8177
HCC2998 GDSC1; GDSC2 5.4874 12.1023 0.579 11.4559
NCI-H508 GDSC1 5.4887 7.0943 2.7968 0.4591
MDST8 GDSC1; GDSC2 5.4941 10.7378 1.2302 7.9522
SNU-175 GDSC2 5.5283 11.9933 0.6585 10.9566
NCI-H716 GDSC1; GDSC2 5.6071 8.4602 2.3147 2.0677
SNU-61 GDSC1; GDSC2 5.6126 7.2563 2.7861 0.3432
LS1034 GDSC1; GDSC2 5.6325 7.1773 2.8216 0.2589
CCK-81 GDSC1; GDSC2 5.6361 8.9012 2.143 2.8476
SNU-C1 GDSC1; GDSC2 5.6715 13.7221 -0.0742 14.3012
HT-55 GDSC1; GDSC2 5.7741 12.3632 0.6452 10.5285
COLO 320HSR GDSC1; GDSC2 5.7933 7.6476 2.7147 0.4411
SW620 GDSC1; GDSC2 5.9983 8.0324 2.6549 0.5019
SW837 GDSC1; GDSC2 6.175 7.8374 2.7888 0.1729
LS180 GDSC1; GDSC2 6.8512 18.1212 -1.3831 17.3778
COLO 678 GDSC1; GDSC2 6.9485 18.1885 -1.3493 17.0645
SNU-C2B GDSC1; GDSC2 7.1644 9.8742 2.44 0.5369
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 4.6742 6.7556 2.558 2.044
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 GDSC1; GDSC2 3.7175 5.8667 2.3623 5.0176
Huh-7 GDSC1; GDSC2 4.068 6.9498 2.0858 5.9015
Hep 3B2.1-7 GDSC1; GDSC2 4.7205 6.5766 2.6594 1.4815
HLE GDSC1; GDSC2 4.737 11.8734 0.1605 15.293
Hep-G2/C3A GDSC1; GDSC2 4.7376 6.5131 2.6946 1.297
SNU-423 GDSC1; GDSC2 4.88 12.5372 -0.0605 16.0312
JHH-1 GDSC1; GDSC2 4.9745 16.1079 -1.7515 22.7345
JHH-4 GDSC1; GDSC2 5.0937 7.9001 2.2863 2.8566
JHH-7 GDSC1; GDSC2 5.2155 12.8949 0.0071 14.9216
SNU-398 GDSC1; GDSC2 5.4353 7.3909 2.6645 0.7948
JHH-2 GDSC1; GDSC2 5.5072 7.2201 2.7583 0.4604
SK-HEP-1 GDSC1; GDSC2 5.6507 11.0271 1.1939 7.8559
HuH-1 GDSC1; GDSC2 5.8918 15.8197 -0.9363 17.5989
SNU-449 GDSC1; GDSC2 6.0145 8.8563 2.3472 1.5244
SNU-387 GDSC1; GDSC2 6.957 20.1269 -2.2778 20.2577
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L32 GDSC1 0.8687 10.7609 -2.598 41.9994
LB647-SCLC GDSC1 1.7481 17.7331 -5.2338 41.9358
NCI-H1876 GDSC1; GDSC2 2.1452 9.598 -0.8437 27.5476
NCI-H1703 GDSC1 2.3285 10.9285 -1.338 32.9608
NCI-H69 GDSC1 3.2956 9.0787 0.4215 21.4169
RERF-LC-KJ GDSC1; GDSC2 3.3357 6.7994 1.5947 10.8678
SBC-1 GDSC1 3.3689 13.3568 -1.6564 30.157
NCI-H1341 GDSC1 3.4563 8.8928 0.6476 19.4758
DMS 273 GDSC1; GDSC2 3.5309 11.1169 -0.4028 21.2095
CAL-12T GDSC1 3.5547 7.6024 1.3724 14.2904
NCI-H647 GDSC1 3.6606 8.9372 0.7913 17.8469
NCI-H1568 GDSC1; GDSC2 3.665 8.9446 0.7911 14.7258
IST-SL1 GDSC1 3.7374 18.327 -3.8373 34.3845
RERF-LC-MS GDSC1 3.8048 6.9724 1.8818 9.6743
NCI-H2030 GDSC1 3.8203 6.3392 2.2058 7.1456
NCI-H1869 GDSC1; GDSC2 3.8301 7.422 1.6785 8.9912
LCLC-97TM1 GDSC1; GDSC2 3.862 9.1982 0.8209 14.013
HCC44 GDSC1; GDSC2 3.8708 6.5265 2.1509 5.9613
NCI-H345 GDSC1; GDSC2 3.8913 8.1882 1.3455 10.8637
UMC-11 GDSC1; GDSC2 3.9514 7.7088 1.6285 8.9905
NCI-H82 GDSC1; GDSC2 3.9884 6.4595 2.2679 4.966
NCI-H596 GDSC1; GDSC2 3.9972 9.444 0.8039 13.7467
COR-L311 GDSC2 4.0172 9.7151 0.6847 14.3595
NCI-H1688 GDSC1 4.0311 12.0077 -0.445 23.2935
NCI-H1694 GDSC1; GDSC2 4.0342 12.2536 -0.5651 20.5141
NCI-H1437 GDSC1 4.0692 6.3144 2.3933 5.0161
NCI-H661 GDSC1; GDSC2 4.0949 6.5426 2.3013 4.5293
NCI-H1650 GDSC1; GDSC2 4.1106 6.8445 2.1667 5.3121
EPLC-272H GDSC1; GDSC2 4.1808 12.5876 -0.6161 20.3419
DMS 114 GDSC1; GDSC2 4.1926 6.2559 2.5015 3.1415
NCI-H524 GDSC1; GDSC2 4.2071 7.5316 1.9014 6.7119
NCI-H196 GDSC1; GDSC2 4.2277 7.521 1.921 6.5463
Lu-135 GDSC1; GDSC2 4.2401 8.2379 1.5808 8.5781
NCI-H2369 GDSC1; GDSC2 4.2565 8.4168 1.5051 8.994
EBC-1 GDSC1; GDSC2 4.2947 7.5746 1.9415 6.2743
NCI-H146 GDSC1 4.2954 11.9904 -0.2301 21.4282
NCI-H2066 GDSC1 4.2992 7.6849 1.8914 8.1387
NCI-H2029 GDSC1; GDSC2 4.3004 11.3769 0.078 16.8008
NCI-H2444 GDSC1 4.3101 5.8948 2.7357 2.0413
NCI-H1975 GDSC1; GDSC2 4.3179 7.518 1.9847 5.9639
NCI-H2347 GDSC1 4.3443 6.7524 2.3654 4.5417
NCI-H847 GDSC1 4.3538 9.9769 0.8103 15.4458
LK-2 GDSC1; GDSC2 4.3544 7.2154 2.1538 4.8753
NCI-H720 GDSC1; GDSC2 4.3574 8.0896 1.7362 7.3732
NCI-H1836 GDSC1 4.3775 15.01 -1.6674 27.0294
NCI-H2009 GDSC1 4.4019 11.3216 0.1826 18.9692
CPC-N GDSC1; GDSC2 4.4023 15.7769 -2.0297 25.0567
NCI-H1755 GDSC1; GDSC2 4.4047 9.9933 0.8399 12.5039
NCI-H446 GDSC1; GDSC2 4.4139 8.2949 1.6762 7.6068
COR-L279 GDSC1 4.4256 6.4486 2.5544 3.0332
NCI-H835 GDSC1 4.4368 20.1284 -4.1712 33.2087
NCI-H838 GDSC1 4.4464 7.472 2.0926 6.2766
NCI-H526 GDSC1; GDSC2 4.4571 6.6055 2.5019 2.6732
NCI-H1581 GDSC1; GDSC2 4.4628 8.5189 1.6019 7.9414
NCI-H2081 GDSC1 4.5268 7.3845 2.1855 5.4097
SBC-5 GDSC1; GDSC2 4.535 12.5822 -0.3402 18.1932
NCI-H1435 GDSC1; GDSC2 4.5527 8.7276 1.5633 7.9718
NCI-H187 GDSC1 4.5658 12.2952 -0.1749 20.3216
Ms-1 GDSC1; GDSC2 4.5719 9.8379 1.0378 10.9851
NCI-H1304 GDSC1 4.5822 6.3619 2.6793 1.938
NCI-H292 GDSC1 4.5842 11.3016 0.3289 17.6046
NCI-H2110 GDSC1 4.6039 12.1935 -0.0961 19.8119
LC-1/sq GDSC1; GDSC2 4.6408 7.6617 2.128 4.4714
NCI-H2595 GDSC1; GDSC2 4.6469 6.5214 2.6448 1.6431
Lu-65 GDSC1; GDSC2 4.65 7.9064 2.0194 5.0835
NCI-H2087 GDSC1; GDSC2 4.6589 7.8057 2.0722 4.76
LC-2/ad GDSC1 4.6642 11.8769 0.105 18.5882
NCI-H1770 GDSC1 4.673 15.767 -1.8136 26.6663
NCI-H23 GDSC1; GDSC2 4.6766 6.5243 2.659 1.5363
DMS 53 GDSC1; GDSC2 4.6848 7.6168 2.1761 4.1158
NCI-H1105 GDSC1 4.6927 18.408 -3.1113 30.2874
LXF 289 GDSC1; GDSC2 4.6963 7.2136 2.3671 3.0273
HCC366 GDSC1; GDSC2 4.704 7.9965 2.0116 5.0259
NCI-H1092 GDSC1; GDSC2 4.7255 8.4398 1.8169 6.1173
BEN GDSC1 4.7488 15.1784 -1.4632 25.246
COR-L88 GDSC1 4.7531 11.8241 0.1966 17.8334
NCI-H290 GDSC1 4.766 7.2685 2.3825 3.5267
NCI-H209 GDSC1; GDSC2 4.785 13.3141 -0.5134 18.3485
NCI-H2228 GDSC1; GDSC2 4.845 8.5842 1.826 5.8311
COR-L321 GDSC1 4.8521 24.6279 -6.0842 35.3243
EKVX GDSC1; GDSC2 4.8583 11.6071 0.3796 13.8893
SHP-77 GDSC1; GDSC2 4.875 13.1916 -0.386 17.5596
NCI-H441 GDSC1; GDSC2 4.8867 13.0239 -0.2948 17.1157
NCI-H2795 GDSC1; GDSC2 4.9042 13.127 -0.3326 17.2466
NCI-H2373 GDSC1; GDSC2 4.9064 8.1357 2.0723 4.3136
ChaGo-K-1 GDSC1 4.9144 12.1283 0.165 17.5369
NCI-H1155 GDSC1; GDSC2 4.9218 7.4107 2.4066 2.4775
NCI-H1573 GDSC1 4.929 6.7413 2.6934 1.3736
NCI-H1792 GDSC1; GDSC2 4.9317 10.1693 1.1291 9.6569
NCI-H2461 GDSC1; GDSC2 4.9389 11.9251 0.2821 14.1991
NCI-H1993 GDSC1; GDSC2 4.9625 7.7847 2.264 3.1682
HCC15 GDSC1; GDSC2 4.9975 7.3377 2.4786 2.0139
COLO 668 GDSC1; GDSC2 5.0131 10.0726 1.2307 8.9101
EMC-BAC-2 GDSC1; GDSC2 5.0153 10.5162 1.0195 10.0906
NCI-H1838 GDSC1 5.0232 7.5429 2.4038 2.9276
LOU-NH91 GDSC1; GDSC2 5.026 7.4921 2.4273 2.231
SK-MES-1 GDSC1; GDSC2 5.066 7.1355 2.5979 1.3778
NCI-H1963 GDSC2 5.091 6.9308 2.6924 0.9589
NCI-H1693 GDSC1; GDSC2 5.0932 7.662 2.3897 2.3303
NCI-H1781 GDSC1; GDSC2 5.0935 6.8635 2.7201 0.8502
NCI-H810 GDSC1; GDSC2 5.1213 12.3504 0.2052 14.1644
HOP-62 GDSC1; GDSC2 5.1348 7.0824 2.652 1.082
NCI-H1355 GDSC1; GDSC2 5.1369 9.2785 1.6861 6.0806
PaCa-3 GDSC1 5.141 9.2411 1.706 7.346
NCI-H1944 GDSC1; GDSC2 5.1496 8.4013 2.0952 3.7862
COR-L95 GDSC1 5.1541 12.0004 0.3986 15.58
NCI-H2023 GDSC1; GDSC2 5.1575 9.1176 1.7735 5.5504
NCI-H2810 GDSC1; GDSC2 5.1628 10.8641 0.9527 10.1434
PC-14 GDSC1; GDSC2 5.1752 7.2712 2.5947 1.2821
COR-L23 GDSC1; GDSC2 5.1915 6.8922 2.7516 0.6645
SBC-3 GDSC1; GDSC2 5.2047 11.7175 0.5708 12.1052
DMS 79 GDSC1; GDSC2 5.2153 7.7463 2.4172 2.042
NCI-H2722 GDSC1; GDSC2 5.2153 7.4586 2.5373 1.49
SW1573 GDSC1; GDSC2 5.2514 11.9837 0.4746 12.5036
HCC78 GDSC1; GDSC2 5.2864 7.5417 2.5374 1.4171
NCI-H1915 GDSC1; GDSC2 5.2873 10.4463 1.2343 8.3307
VMRC-LCD GDSC1; GDSC2 5.3117 7.6233 2.5162 1.4834
NCI-H841 GDSC1; GDSC2 5.32 7.1596 2.704 0.7391
NCI-H522 GDSC1; GDSC2 5.3213 7.0005 2.7648 0.5409
NCI-H650 GDSC1; GDSC2 5.3377 6.9204 2.801 0.4274
NCI-H1299 GDSC1; GDSC2 5.3663 7.2857 2.6754 0.8059
NCI-H2804 GDSC1; GDSC2 5.3747 13.2181 -0.0374 14.7759
Lu-165 GDSC1; GDSC2 5.3759 6.9938 2.7892 0.4407
NCI-H2135 GDSC1; GDSC2 5.3959 6.9144 2.8259 0.3366
A-427 GDSC1; GDSC2 5.3989 9.7423 1.6332 5.9039
Calu-6 GDSC1; GDSC2 5.3991 6.9929 2.7987 0.404
NCI-H1623 GDSC1; GDSC2 5.4214 10.3613 1.3602 7.3735
NCI-H3255 GDSC1; GDSC2 5.4221 8.6916 2.1193 3.2535
NCI-H1436 GDSC1 5.4249 7.1438 2.7535 0.6434
HCC827 GDSC1; GDSC2 5.4303 7.7282 2.5296 1.3122
IA-LM GDSC1; GDSC2 5.4441 7.5942 2.5892 1.0631
NCI-H1793 GDSC1; GDSC2 5.4614 7.707 2.5524 1.1921
NCI-H211 GDSC1; GDSC2 5.508 7.7026 2.5751 1.0647
NCI-H2291 GDSC1 5.5082 7.3687 2.7036 0.7716
NCI-H226 GDSC1; GDSC2 5.5093 16.279 -1.4364 20.3747
SW1271 GDSC1; GDSC2 5.5155 7.437 2.6809 0.6867
NCI-H1648 GDSC1 5.5226 9.1615 1.9681 4.8192
NCI-H2122 GDSC1; GDSC2 5.5273 9.271 1.9221 4.1277
LCLC-103H GDSC1; GDSC2 5.5442 6.7399 2.9402 0.0912
NCI-H2227 GDSC1; GDSC2 5.587 7.2897 2.7642 0.4073
NCI-H2172 GDSC1 5.5997 7.3315 2.754 0.533
NCI-H1048 GDSC1; GDSC2 5.6142 13.211 0.1328 13.4331
NCI-H3122 GDSC1; GDSC2 5.7006 7.9288 2.5716 0.9309
NCI-H358 GDSC1; GDSC2 5.7204 11.5123 1.0114 8.7073
HOP-92 GDSC1; GDSC2 5.7249 9.7416 1.8244 4.3436
NCI-H460 GDSC1 5.7314 7.0887 2.8875 0.1547
Lu-99A GDSC1; GDSC2 5.7686 8.6312 2.3229 1.8591
NCI-H1666 GDSC1; GDSC2 5.8128 11.8972 0.8899 9.1764
NCI-H1651 GDSC1; GDSC2 5.8295 7.5161 2.7754 0.2882
NCI-H2141 GDSC1; GDSC2 5.842 17.1536 -1.6227 20.3179
NCI-H2085 GDSC1; GDSC2 5.8575 7.8373 2.6707 0.5267
NCI-H513 GDSC1; GDSC2 5.8676 12.8888 0.4574 11.3002
Calu-3 GDSC1; GDSC2 5.8733 7.985 2.6226 0.6554
COR-L105 GDSC1; GDSC2 5.8806 12.1408 0.8189 9.4197
SK-LU-1 GDSC1; GDSC2 5.8927 8.7155 2.3474 1.6339
Lu-134-A GDSC1 5.9136 12.765 0.5462 12.8084
RERF-LC-Sq1 GDSC1; GDSC2 5.925 9.8445 1.8894 3.7251
NCI-H1563 GDSC1; GDSC2 5.9368 7.5905 2.7887 0.2304
NCI-H2818 GDSC1; GDSC2 5.977 9.1026 2.2299 2.0512
ABC-1 GDSC1; GDSC2 5.9783 7.8351 2.7181 0.3582
NCI-H2342 GDSC1 5.9884 16.5752 -1.2354 21.1114
EMC-BAC-1 GDSC1 6.0097 8.8979 2.3284 1.9947
NCI-H727 GDSC1; GDSC2 6.0272 7.8504 2.731 0.3136
NCI-H250 GDSC2 6.0488 8.0539 2.6667 0.4501
NCI-H2803 GDSC1; GDSC2 6.088 13.7888 0.1753 12.2516
Lu-139 GDSC1; GDSC2 6.1022 16.2075 -0.9767 17.316
IST-SL2 GDSC1; GDSC2 6.1202 8.2471 2.6245 0.525
NCI-H520 GDSC1; GDSC2 6.2201 7.9726 2.7586 0.2087
KNS-62 GDSC1; GDSC2 6.2372 14.1306 0.1113 12.2646
NCI-H2869 GDSC1; GDSC2 6.2711 14.2984 0.054 12.4695
NCI-H322M GDSC1; GDSC2 6.312 8.2607 2.6921 0.3005
NCI-H2731 GDSC1; GDSC2 6.357 13.4935 0.4882 10.2088
NCI-H2591 GDSC1; GDSC2 6.3729 14.6783 -0.0593 12.7999
NCI-H2405 GDSC1; GDSC2 6.4164 8.9011 2.502 0.7124
NCI-H2170 GDSC1; GDSC2 6.4629 14.3905 0.1352 11.7184
A-549 GDSC1; GDSC2 6.4663 13.8024 0.4129 10.3781
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 9.4724 24.737 -2.7964 17.5442
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.157 7.5022 2.4905 1.7655
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T.T GDSC1 3.5071 5.1935 2.5356 5.5624
KYSE-150 GDSC1 3.8611 11.2473 -0.2009 22.7022
OE21 GDSC1; GDSC2 4.2542 9.1498 1.1437 11.139
TE-1 GDSC1; GDSC2 4.348 6.1048 2.664 1.9623
TE-9 GDSC1; GDSC2 4.4687 6.8978 2.3752 3.3654
TE-5 GDSC1; GDSC2 4.5252 6.6672 2.5137 2.4992
KYSE-140 GDSC1; GDSC2 4.548 9.3898 1.2392 9.8833
KYSE-70 GDSC1; GDSC2 4.5843 7.167 2.3218 3.4657
TE-10 GDSC1 4.6828 10.9011 0.598 15.7564
KYSE-270 GDSC1; GDSC2 4.718 7.7468 2.1364 4.2825
OE33 GDSC1; GDSC2 4.8424 10.3982 0.9569 10.8202
KYSE-180 GDSC1; GDSC2 4.9095 7.0509 2.5552 1.7513
COLO 680N GDSC1; GDSC2 5.0271 7.1319 2.5804 1.4978
KYSE-450 GDSC1; GDSC2 5.2306 6.7249 2.8303 0.4002
KYSE-510 GDSC1 5.3803 7.6231 2.5486 1.5938
TE-6 GDSC1; GDSC2 5.6298 7.7691 2.6026 0.8728
EC-GI-10 GDSC1; GDSC2 5.7329 9.3424 2.0041 3.4101
KYSE-520 GDSC1; GDSC2 5.7791 12.4954 0.5859 10.8239
TE-8 GDSC1; GDSC2 5.835 7.8408 2.6605 0.566
TE-4 GDSC1; GDSC2 5.9346 7.6551 2.7654 0.2746
TE-15 GDSC1; GDSC2 6.0331 8.5094 2.4911 0.9765
OE19 GDSC1; GDSC2 6.2496 14.2531 0.0614 12.4765
KYSE-410 GDSC1; GDSC2 6.379 8.2389 2.7238 0.2264
TE-11 GDSC1 6.3891 14.7661 -0.0902 15.0732
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 2.0761 5.7363 0.9664 23.2844
JHOS-4 GDSC1 3.266 6.4848 1.6937 12.9644
OVCAR-8 GDSC1; GDSC2 3.6961 8.06 1.257 11.9167
OV56 GDSC1; GDSC2 4.2648 5.7559 2.7718 1.5158
TYK-nu GDSC1; GDSC2 4.2665 7.3721 2.0197 5.8633
SK-OV-3 GDSC1; GDSC2 4.4035 10.5638 0.5581 14.0529
TOV-21G GDSC1; GDSC2 4.4036 6.5805 2.4815 2.8772
TOV-112D GDSC1; GDSC2 4.471 7.0707 2.2966 3.8118
FU-OV-1 GDSC1 4.4915 11.6436 0.0911 19.1835
OVTOKO GDSC1; GDSC2 4.778 9.4813 1.355 8.6994
JHOS-2 GDSC1 4.8046 7.9338 2.1033 5.3601
OAW42 GDSC1; GDSC2 4.8054 5.6624 3.0472 0.0863
Caov-4 GDSC1 4.8648 14.7725 -1.1739 23.8352
IGROV-1 GDSC2 4.8961 9.1182 1.6073 6.9942
OVCAR-4 GDSC1; GDSC2 4.8974 8.9692 1.6785 6.5804
OAW28 GDSC1; GDSC2 4.9855 8.7917 1.8178 5.6129
OVK18 GDSC1; GDSC2 5.0251 7.4256 2.4554 2.0928
EFO-21 GDSC1; GDSC2 5.111 12.3666 0.1899 14.2644
Kuramochi GDSC1; GDSC2 5.1237 7.3387 2.5422 1.5657
OVCAR-5 GDSC1; GDSC2 5.175 7.1141 2.6578 1.0233
OVKATE GDSC1 5.3063 8.6356 2.0798 4.5
A2780 GDSC1; GDSC2 5.3282 11.0837 0.9588 9.7653
OVISE GDSC1; GDSC2 5.3817 9.8411 1.5771 6.2449
RMG-I GDSC1 5.4226 12.1598 0.5074 14.2478
ES-2 GDSC1; GDSC2 5.4866 6.9861 2.8347 0.2813
DOV13 GDSC1; GDSC2 5.5317 7.3503 2.72 0.5563
OV-90 GDSC1; GDSC2 5.5491 7.3464 2.7285 0.5223
EFO-27 GDSC1; GDSC2 5.9742 12.3176 0.7956 9.3642
OVCAR-3 GDSC1; GDSC2 6.4957 16.8036 -0.9924 16.5736
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1; GDSC2 3.5661 10.3111 0.0287 19.0638
Panc 03.27 GDSC1 3.6021 11.2161 -0.3942 24.5092
BxPC-3 GDSC1; GDSC2 4.0573 7.8382 1.6435 8.6367
SW1990 GDSC1 4.2774 10.3386 0.5745 17.1278
PaTu 8988t GDSC1; GDSC2 4.4518 12.4134 -0.32 18.3124
KP-1N GDSC1; GDSC2 4.4532 7.7119 1.983 5.6889
HPAC GDSC1; GDSC2 4.4556 8.3203 1.6928 7.4154
Panc 04.03 GDSC1 4.7043 11.1197 0.5065 16.2319
MZ-PC-1 GDSC1 4.7094 9.1987 1.444 10.219
KP-3 GDSC1; GDSC2 4.8096 8.0401 2.0572 4.5694
Panc 08.13 GDSC1; GDSC2 4.8114 13.0485 -0.3628 17.6091
DAN-G GDSC1; GDSC2 4.8431 7.1084 2.4956 2.1307
YAPC GDSC1; GDSC2 4.8667 9.7505 1.2861 8.9048
HuP-T4 GDSC1; GDSC2 4.9053 7.2163 2.4822 2.1153
PL4 GDSC1; GDSC2 4.9229 7.5332 2.3533 2.7533
Hs 766T GDSC1 4.993 6.8953 2.6612 1.4665
CFPAC-1 GDSC1; GDSC2 5.0221 7.3492 2.4864 1.9451
KP-4 GDSC1; GDSC2 5.1056 12.5031 0.1196 14.625
PaTu 8902 GDSC1; GDSC2 5.15 6.5856 2.8495 0.3878
AsPC-1 GDSC1; GDSC2 5.2223 9.1514 1.7975 5.3022
SU.86.86 GDSC1; GDSC2 5.244 6.6134 2.8758 0.28
HuP-T3 GDSC1; GDSC2 5.2508 7.3662 2.5917 1.2224
Panc 10.05 GDSC1; GDSC2 5.3844 8.1527 2.3317 2.2468
QGP-1 GDSC1; GDSC2 5.4013 15.864 -1.3118 20.1539
SUIT-2 GDSC1; GDSC2 5.4966 7.2718 2.735 0.5315
Capan-1 GDSC1; GDSC2 5.523 8.0067 2.4605 1.5127
KP-2 GDSC1; GDSC2 5.6709 7.14 2.8486 0.1971
Panc 02.03 GDSC1; GDSC2 5.6955 7.3122 2.7974 0.2877
Capan-2 GDSC1; GDSC2 5.7978 7.5368 2.7562 0.3404
HPAF-II GDSC1; GDSC2 5.9353 16.0194 -1.0027 17.773
PSN1 GDSC1; GDSC2 7.1427 20.0308 -2.1025 19.3371
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1; GDSC2 4.305 8.4692 1.5145 8.8238
MSTO-211H GDSC1; GDSC2 4.4108 6.8533 2.3602 3.5556
NCI-H2452 GDSC1 4.6925 10.9395 0.5862 15.798
MPP 89 GDSC1; GDSC2 4.7123 6.8294 2.5465 2.0501
IST-Mes1 GDSC1; GDSC2 5.8235 18.8811 -2.484 23.1925
NCI-H2052 GDSC2 5.8956 13.2969 0.2819 12.1181
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 4.439 9.403 1.1547 10.628
VCaP GDSC1; GDSC2 4.5244 7.9053 1.9383 5.8085
DU145 GDSC1; GDSC2 5.0162 7.3166 2.4973 1.8999
PC-3 GDSC1; GDSC2 5.2472 14.3242 -0.6688 17.9225
22Rv1 GDSC1; GDSC2 6.143 13.4795 0.3578 11.2554
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 4.4503 7.8095 1.9346 5.9834
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MeWo GDSC1 2.2232 11.9011 -1.9145 35.0211
LB2518-MEL GDSC1 3.1275 12.5854 -1.4728 30.3945
Mel Ho GDSC1 3.4863 20.0534 -4.9072 36.8187
SK-MEL-30 GDSC1 3.4886 5.8966 2.1707 8.4858
SH-4 GDSC1; GDSC2 3.5152 6.4963 1.8928 8.4947
A-388 GDSC1 3.6619 9.3447 0.5889 19.0934
SK-MEL-2 GDSC1; GDSC2 3.7556 6.3589 2.148 6.2614
COLO 800 GDSC1 3.874 8.517 1.1689 14.6256
G-mel GDSC1; GDSC2 3.9865 7.1831 1.9133 7.1529
RVH-421 GDSC1 4.0231 9.8364 0.629 17.6196
SK-MEL-28 GDSC1 4.089 5.2907 2.8794 1.5032
A2058 GDSC1; GDSC2 4.2486 7.0137 2.1795 4.9394
GAK GDSC1; GDSC2 4.2701 6.2036 2.5736 2.5874
VMRC-MELG GDSC1 4.2734 6.927 2.2373 5.6503
WM35 GDSC1 4.274 18.1295 -3.3042 31.8402
Hs 938.T GDSC1 4.28 7.081 2.1684 6.1425
UACC-62 GDSC1; GDSC2 4.323 6.3785 2.5255 2.768
A101D GDSC1; GDSC2 4.3249 10.5047 0.5283 14.4114
MZ-MEL-2 GDSC1 4.392 6.477 2.5218 3.3261
Mel JuSo GDSC1; GDSC2 4.4303 6.6868 2.4489 3.0148
DJM-1 GDSC1 4.4396 8.9328 1.3846 11.3812
SK-MEL-1 GDSC1 4.4858 6.3326 2.6402 2.3477
A-375 GDSC1; GDSC2 4.518 6.83 2.436 2.9382
MZ-MEL-7 GDSC1 4.5194 13.6086 -0.8607 23.5828
MMAc-SF GDSC1 4.5477 10.6765 0.6095 16.0878
LB373-MEL-D GDSC1 4.6302 10.2105 0.8977 14.0672
COLO 783 GDSC1 4.6485 6.8837 2.4873 3.0526
COLO 679 GDSC1; GDSC2 4.7612 12.5277 -0.1435 16.7142
451Lu GDSC1 4.8179 7.9292 2.1135 5.2596
IGR-1 GDSC1; GDSC2 4.8271 6.9684 2.5476 1.892
WM278 GDSC1; GDSC2 4.8559 10.0565 1.1314 9.8093
SK-MEL-5 GDSC1; GDSC2 4.8576 10.9939 0.6782 12.3143
HMV-II GDSC1; GDSC2 4.8648 12.0217 0.1812 14.8826
M14 GDSC1; GDSC2 4.8664 13.8357 -0.7099 19.0006
WT2-iPS GDSC1; GDSC2 4.8839 6.4313 2.7965 0.7301
RPMI-7951 GDSC1; GDSC2 4.911 6.3066 2.8562 0.5019
G-361 GDSC1; GDSC2 4.9482 14.8929 -1.1704 20.6725
A-431 GDSC1 5.0329 14.6863 -1.005 22.6928
WM115 GDSC1; GDSC2 5.156 13.6437 -0.4017 16.9636
Hs 940.T GDSC1 5.2525 7.3856 2.5848 1.5563
LOX-IMVI GDSC1; GDSC2 5.3138 10.4253 1.2614 8.1281
WM793 GDSC1; GDSC2 5.3436 10.2938 1.3424 7.6201
CP66-MEL GDSC1; GDSC2 5.3727 8.3176 2.2551 2.6345
UACC-257 GDSC1; GDSC2 5.3764 14.6805 -0.7495 17.9677
WM1552C GDSC1; GDSC2 5.4223 7.021 2.7976 0.3962
CP50-MEL-B GDSC1 5.4585 7.3678 2.6832 0.8914
SK-MEL-31 GDSC1 5.4672 6.7013 2.9265 0.1523
COLO 792 GDSC1; GDSC2 5.4864 8.6268 2.1821 2.8483
SK-MEL-24 GDSC1; GDSC2 5.6744 7.7542 2.6272 0.7601
CHL-1 GDSC1; GDSC2 5.7134 9.2874 2.0175 3.3694
HT-144 GDSC1; GDSC2 5.7218 7.6749 2.6764 0.5802
IST-MEL1 GDSC1 5.8961 8.7808 2.3226 2.156
COLO 829 GDSC1; GDSC2 5.9515 8.4622 2.474 1.0942
IGR-37 GDSC1; GDSC2 6.0298 14.5315 -0.2183 14.2162
IPC-298 GDSC1 6.3904 16.3128 -0.8283 18.4782
SK-MEL-3 GDSC1 6.7253 24.9496 -4.8032 29.3865
EquiPSC Line K2 GDSC1 5.2549 13.8228 -0.4177 19.5131
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 6.4494 18.9121 -2.0455 20.5016
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC1; GDSC2 3.1659 6.9233 1.3896 12.6405
EW-8 GDSC1; GDSC2 3.4309 5.8151 2.1649 7.0139
SW684 GDSC1; GDSC2 4.0851 9.2015 0.9914 12.4485
STS-0421 GDSC1 4.1972 8.6011 1.3715 12.1907
Rh30 GDSC1; GDSC2 4.2461 6.952 2.2073 4.7774
Hs 633.T GDSC1 4.3049 6.4573 2.478 3.8232
G-402 GDSC1; GDSC2 4.6074 8.362 1.7759 6.5978
Rh41 GDSC1; GDSC2 4.6159 6.4271 2.6689 1.5639
MES-SA GDSC1; GDSC2 4.6726 6.2176 2.7848 0.9645
RKN GDSC1; GDSC2 4.8456 6.1384 2.8924 0.4273
Rh18 GDSC1 4.8642 8.1745 2.0287 5.7471
SW872 GDSC1; GDSC2 4.8985 6.9953 2.5731 1.679
VA-ES-BJ GDSC1; GDSC2 4.964 7.0581 2.5798 1.5712
SW982 GDSC1; GDSC2 4.9712 6.4427 2.8298 0.5494
SK-UT-1 GDSC1; GDSC2 5.1275 7.5121 2.4715 1.8892
G-401 GDSC1; GDSC2 5.3418 12.7567 0.1634 13.8757
GCT GDSC1; GDSC2 5.4364 11.0752 1.0341 9.1364
HT-1080 GDSC1; GDSC2 5.66 6.8136 2.955 0.061
MFH-ino GDSC1 5.722 8.2912 2.4387 1.7637
SK-LMS-1 GDSC1; GDSC2 5.988 7.8215 2.7266 0.3363
RD GDSC1; GDSC2 6.1889 9.2541 2.2684 1.6857
A-204 GDSC1; GDSC2 6.8207 16.4306 -0.5961 14.3128
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 GDSC1; GDSC2 3.4049 12.4378 -1.167 24.7471
TMK-1 GDSC1 3.6114 6.6998 1.8678 10.414
SNU-5 GDSC1; GDSC2 3.7155 7.9435 1.3304 11.4221
MKN45 GDSC1; GDSC2 3.8395 6.9533 1.9175 7.4871
SCH GDSC1 4.2901 10.8742 0.3191 18.5664
HSC-39 GDSC1 4.3468 6.2743 2.5871 2.968
ECC12 GDSC2 4.6336 6.1354 2.7998 0.9391
SNU-16 GDSC1 4.7411 6.254 2.8022 1.0314
MKN1 GDSC1; GDSC2 4.793 6.9983 2.5165 2.0927
IM95 GDSC1; GDSC2 4.8124 8.817 1.6951 6.6532
RERF-GC-1B GDSC1; GDSC2 4.914 7.9911 2.1429 3.9068
Fu97 GDSC1 4.9956 17.8795 -2.6134 28.2096
Hs 746.T GDSC1; GDSC2 5.0123 10.2077 1.1655 9.2792
AGS GDSC1; GDSC2 5.0713 13.2948 -0.2923 16.6649
HGC-27 GDSC1; GDSC2 5.0955 7.686 2.3805 2.3731
MKN28 GDSC1; GDSC2 5.2853 7.4437 2.5766 1.2529
OCUM-1 GDSC1; GDSC2 5.2859 8.4048 2.1704 3.1832
NUGC-4 GDSC1; GDSC2 5.5369 7.2359 2.7642 0.4303
TGBC11TKB GDSC1; GDSC2 5.5522 7.1579 2.7983 0.3387
RF-48 GDSC1; GDSC2 5.5546 7.3125 2.7432 0.4783
NUGC-3 GDSC1; GDSC2 5.5623 7.3157 2.7451 0.4693
KATO III GDSC1; GDSC2 5.6172 7.2756 2.781 0.3535
GCIY GDSC2 5.9427 8.8304 2.3244 1.6824
NCI-N87 GDSC1; GDSC2 6.0426 8.4861 2.5039 0.9267
SK-GT-2 GDSC1; GDSC2 6.0884 8.1831 2.6353 0.5115
MKN7 GDSC1 6.154 7.9971 2.7263 0.3524
SNU-1 GDSC1; GDSC2 6.5881 8.3761 2.7505 0.1462
23132/87 GDSC1; GDSC2 6.8913 19.9713 -2.2484 20.2902
SNG-M GDSC1; GDSC2 4.6159 7.0555 2.3915 3.0233
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 4.4218 6.2153 2.6564 2.3573
B-CPAP GDSC1; GDSC2 4.4441 6.8932 2.3623 3.4833
K5 GDSC1; GDSC2 4.6782 7.274 2.3291 3.2661
CAL-62 GDSC1; GDSC2 4.6861 6.1958 2.8 0.8873
FTC-133 GDSC1; GDSC2 4.7902 7.0924 2.474 2.3144
IHH-4 GDSC1; GDSC2 4.8681 6.7903 2.6439 1.384
KMH-2 GDSC1 4.8875 10.7035 0.8405 13.6958
ML-1 [Human leukemia] GDSC1 4.9693 9.3297 1.555 8.7852
TT2609-C02 GDSC1; GDSC2 4.9705 7.1123 2.5603 1.6546
BHT-101 GDSC1; GDSC2 5.1295 11.1399 0.7975 11.0611
HTC-C3 GDSC1; GDSC2 5.1367 7.1657 2.6193 1.2153
8505C GDSC1; GDSC2 5.2779 7.6156 2.5031 1.5758
WRO GDSC1; GDSC2 5.2967 6.9508 2.7733 0.5293
8305C GDSC1; GDSC2 5.648 10.8784 1.2615 7.4948
ASH-3 GDSC1; GDSC2 5.758 7.8769 2.6157 0.7445
TT GDSC1 6.1811 15.4473 -0.5552 17.7734
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 3.2502 7.176 1.3348 15.6707
HSC-3 GDSC1; GDSC2 3.3184 4.8378 2.561 4.8279
KOSC-2 GDSC1 3.4215 8.6783 0.7263 19.1176
JHU-011 GDSC1 3.6663 9.1728 0.6783 18.5335
PCI-04B GDSC1; GDSC2 3.7309 8.2666 1.1816 12.2726
JHU-029 GDSC1 3.9454 9.1879 0.891 16.2368
SKN-3 GDSC1; GDSC2 4.0109 10.7875 0.1466 17.2256
KON GDSC1 4.0117 8.7155 1.1762 14.1251
HSC-4 GDSC1; GDSC2 4.0391 5.9849 2.5302 3.2711
PCI-30 GDSC1 4.0644 6.9911 2.0633 7.5151
HO-1-u-1 GDSC1 4.1423 7.5068 1.8675 8.7583
HO-1-N-1 GDSC1; GDSC2 4.1863 10.2595 0.5445 14.6807
PCI-06A GDSC1 4.3629 10.9884 0.3179 18.3443
OSC-19 GDSC1 4.3696 11.5558 0.0421 19.8185
SCC-25 GDSC1 4.4017 7.1223 2.2286 5.3965
BB49-HNC GDSC1; GDSC2 4.432 11.231 0.2501 15.5964
Detroit 562 GDSC1; GDSC2 4.534 8.2785 1.7665 6.8079
BICR 22 GDSC1; GDSC2 4.6318 6.499 2.6465 1.6543
BHY GDSC1 4.7189 11.3423 0.408 16.7572
PE/CA-PJ15 GDSC1 4.7295 9.6238 1.2529 11.4649
PCI-38 GDSC1 4.7967 6.6552 2.6647 1.7041
UPCI-SCC-090 GDSC1; GDSC2 4.8598 11.7814 0.2953 14.318
SCC-15 GDSC1; GDSC2 4.9818 8.0315 2.1644 3.677
CAL-33 GDSC1; GDSC2 5.0165 9.7055 1.4079 7.896
HSC-2 GDSC1; GDSC2 5.2345 6.517 2.9064 0.2171
LB771-HNC GDSC1; GDSC2 5.242 10.915 0.9817 9.8181
CAL-27 GDSC1; GDSC2 5.2965 6.8478 2.8113 0.4196
PCI-15A GDSC1 5.3967 7.0228 2.7869 0.5442
SCC-4 GDSC1; GDSC2 5.4131 7.7681 2.5054 1.4293
FaDu GDSC1; GDSC2 5.4419 6.9393 2.8345 0.2982
BICR 10 GDSC1; GDSC2 5.4677 7.687 2.5632 1.1441
DOK GDSC1; GDSC2 5.6219 9.4077 1.9146 4.0258
SAT [Human HNSCC] GDSC1; GDSC2 5.6772 11.5001 0.9895 8.9063
SAS GDSC1; GDSC2 5.7337 15.0947 -0.6957 16.9449
Ca9-22 GDSC1; GDSC2 5.7641 8.659 2.3093 1.9233
NCI-H3118 GDSC1; GDSC2 5.7999 8.8513 2.2474 2.1611
OSC-20 GDSC1; GDSC2 5.8219 7.5 2.7782 0.2849
JHU-022 GDSC1; GDSC2 5.9588 8.2679 2.5516 0.8246
SCC-9 GDSC1; GDSC2 7.0103 17.4205 -0.9412 15.3711
BICR 78 GDSC1; GDSC2 7.1337 19.8922 -2.0418 19.1534
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 3.9799 11.5779 -0.2713 19.3368
UM-UC-3 GDSC1 4.3621 6.4568 2.5132 3.4495
639V GDSC1; GDSC2 4.4328 5.9906 2.7601 1.3484
647V GDSC1; GDSC2 4.6397 13.4215 -0.6761 19.4161
5637 GDSC1; GDSC2 4.7332 7.4671 2.2739 3.4808
T24 GDSC1 4.7363 6.8992 2.5291 2.623
SW780 GDSC1; GDSC2 4.8472 6.8412 2.6121 1.5555
HT-1376 GDSC1; GDSC2 4.8773 7.749 2.231 3.4813
SW1710 GDSC1; GDSC2 4.9152 7.4066 2.4048 2.4961
TCCSUP GDSC1; GDSC2 4.9371 9.0585 1.6621 6.5972
J82 GDSC1; GDSC2 5.019 7.6464 2.3565 2.599
CAL-29 GDSC1; GDSC2 5.1159 12.2511 0.2497 13.954
HT-1197 GDSC1; GDSC2 5.2026 7.9904 2.306 2.6048
BFTC-905 GDSC2 5.2034 6.4304 2.9253 0.1897
RT-4 GDSC1; GDSC2 5.815 13.901 -0.0618 13.9382
RT-112 GDSC1; GDSC2 9.4547 23.4094 -2.187 15.6988
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JEG-3 GDSC1 1.0952 6.5004 -0.363 35.4693
NT2-D1 GDSC1 3.4456 6.0974 2.0358 9.6861
C-4-I GDSC1; GDSC2 3.7633 16.9099 -3.1079 29.7285
LB831-BLC GDSC1; GDSC2 3.9371 5.9486 2.4792 3.7904
JAR GDSC1 4.0338 9.228 0.9392 15.6341
HeLa GDSC1; GDSC2 4.05 7.144 1.9784 6.6016
CAL-39 GDSC1; GDSC2 4.0881 8.6413 1.2706 10.8062
TC-YIK GDSC1; GDSC2 4.1857 9.0182 1.1577 11.2271
UWB1.289 GDSC1 4.4397 6.7454 2.4277 3.8825
SW756 GDSC1; GDSC2 4.4517 6.4192 2.5827 2.2405
SW954 GDSC1 4.502 7.6378 2.0504 6.4444
DoTc2 4510 GDSC1; GDSC2 4.5117 9.5091 1.1551 10.4541
SiSo GDSC1; GDSC2 4.5169 6.5225 2.5736 2.1895
OVCA433 GDSC1 4.5592 9.7838 1.0551 13.2593
OMC-1 [Human cervical carcinoma] GDSC1 4.5923 10.9689 0.4986 16.6096
HT-3 GDSC1; GDSC2 4.629 8.3166 1.8119 6.3412
NEC8 GDSC1; GDSC2 4.7225 8.2975 1.8821 5.7426
SiHa GDSC1; GDSC2 4.7593 6.3544 2.7703 0.9423
SKN GDSC1; GDSC2 4.7669 7.1295 2.4448 2.5009
OVCA420 GDSC1 4.7829 9.888 1.1623 11.9213
SKG-IIIa GDSC1; GDSC2 4.9123 7.837 2.2116 3.5309
OV17R GDSC1 4.9453 10.9284 0.772 13.9582
PA-1 GDSC2 4.9752 11.6226 0.4557 13.2227
JHOS-3 GDSC1 4.9914 8.6106 1.9055 6.3177
SW962 GDSC1 5.029 6.598 2.795 0.7821
KGN GDSC1 5.0912 9.004 1.7851 6.9199
ACC-OV7 GDSC1 5.1446 8.5892 2.0076 5.2939
DSH1 GDSC1; GDSC2 5.2287 7.4887 2.5314 1.5019
PWR-1E GDSC1; GDSC2 5.2464 7.3669 2.5894 1.236
C-33 A GDSC1; GDSC2 5.2731 9.6735 1.5875 6.3837
BPH-1 GDSC1; GDSC2 5.3421 8.997 1.9387 4.3268
Ca Ski GDSC1; GDSC2 5.4736 8.5781 2.1963 2.7947
PEO1 GDSC1; GDSC2 5.5143 7.6793 2.5871 1.0146
ME-180 GDSC1; GDSC2 5.6478 12.8579 0.3253 12.4124
HEC-1 GDSC1; GDSC2 5.7034 7.1778 2.8472 0.1909
HEY GDSC1; GDSC2 5.9226 7.824 2.7009 0.4197
MS751 GDSC1; GDSC2 5.9258 13.8064 0.0588 13.1374
OVMIU GDSC1; GDSC2 6.5874 14.7078 0.066 11.8096
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7698).
2 AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014 Feb 6;123(6):905-13.