General Information of Drug (ID: DMBOV5P)

Drug Name
Sodium oxybate
Synonyms
Sodium oxybate; Oxybate sodium; Sodium Oxybutyrate; Anetamin; Sodium 4-hydroxybutyrate; 4-Hydroxybutyric acid sodium salt; Somsanit; 502-85-2; Catabate; Sodium gamma-hydroxybutyrate; Sodium oxybat; Gamma OH; 4-Hydroxybutyrate sodium; Natrium 4-hydroxybutyrat; Sodium Oxybate [USAN]; Sodium-4-hydroxybutyrate; gamma-Hydroxybutyrate sodium; LUMRYZ; gamma-Hydroxy sodium butyrate; Butanoic acid, 4-hydroxy-, monosodium salt; 4-Hydroxybuttersaeure natriumsalz; gamma-Hydroxybutyrate sodium salt; sodium 4-hydroxybutanoate; WY-3478; Oxybate (sodium); EINECS 207-953-3; JZP-6; NSC 84223; gamma-Hydroxybutyric acid, sodium salt; Butanoic acid, 4-hydroxy-, sodium salt; DTXSID3048940; EB 27; Hydroxybutyric acid monosodium salt; 4-Hydroxybutyric acid monosodium salt; NSC-84223; Sodium gammahydroxybutyrate; UNII-7G33012534; WY 3478; Butyric acid, 4-hydroxy-, monosodium salt; DTXCID6028866; GHB.sodium salt; BUTYRIC ACID, 4-HYDROXY-, SODIUM SALT; .gamma.-hydroxybutyrate sodium salt; XYWAV COMPONENT SODIUM OXYBATE; 7G33012534; SODIUM OXYBATE COMPONENT OF XYWAV; Sodium oxybate (USAN); SODIUM OXYBATE (MART.); SODIUM OXYBATE [MART.]; Oxybate, Sodium; Oxybutyrate, Sodium; NSC84223; GHB Sodium Salt (Sodium Gammahydroxybutyrate); 4 Hydroxybutyrate Sodium; NCGC00247714-01; Sodium gamma Hydroxybutyrate; Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,rel-; Xyrem (TN); SCHEMBL61823; SODIUM OXYBATE [HSDB]; SODIUM OXYBATE [VANDF]; DEA No. 2012; CHEMBL1200682; OXYBATE SODIUM [WHO-DD]; SODIUM OXYBATE [EMA EPAR]; XYGBKMMCQDZQOZ-UHFFFAOYSA-M; HMS2091E15; ; A-Hydroxybutyric acid sodium salt; HY-B1187; Tox21_112871; gamma-Hydroxybutyric acid sodium salt; SODIUM OXYBATE [ORANGE BOOK]; Gamma Hydroxybutyric Acid preparations; GHB.sodium salt, 1mg/ml in Methanol; AKOS006221428; CCG-212465; CS-4796; DB09072; CAS-502-85-2; FT-0626615; D05866; H-4040; SODIUM SALT OF GAMMA-HYDROXYBUTYRIC ACID; .GAMMA.-HYDROXYBUTYRATE SODIUM SALT [MI]; Butanoic acid, 4-hydroxy-, sodium salt (1:1); Q7553347; ?-Hydroxybutyric Acid Sodium Salt (1.0 mg/mL in Methanol)
Indication
Disease Entry ICD 11 Status REF
Narcolepsy 7A20 Approved [1]
Narcolepsy type 1 7A20.0 Approved [2]
Affected Organisms
Humans and other mammals
ATC Code
N01AX11: Sodium oxybate
N01AX: Other general anesthetics
N01A: ANESTHETICS, GENERAL
N01: ANESTHETICS
N: NERVOUS SYSTEM
N07XX04: Sodium oxybate
N07XX: Other nervous system drugs
N07X: OTHER NERVOUS SYSTEM DRUGS
N07: OTHER NERVOUS SYSTEM DRUGS
N: NERVOUS SYSTEM
Drug Type
Small molecule
Structure
3D MOL is unavailable 2D MOL
Chemical Identifiers
Formula
C4H7NaO3
Canonical SMILES
C(CC(=O)[O-])CO.[Na+]
InChI
InChI=1S/C4H8O3.Na/c5-3-1-2-4(6)7;/h5H,1-3H2,(H,6,7);/q;+1/p-1
InChIKey
XYGBKMMCQDZQOZ-UHFFFAOYSA-M
Cross-matching ID
PubChem CID
23663870
UNII
7G33012534
DrugBank ID
DB09072
TTD ID
D40IXR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DE8RJ3F HOT_HUMAN Substrate [3]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DE5KEWZ SSDH_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website.
2 Sodium oxybate FDA Label
3 Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005;28(6):921-30.
4 Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.
5 Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.