Details of the Drug

General Information of Drug (ID: DMBQ2TF)

Drug Name
AZD-5438
Synonyms
602306-29-6; AZD5438; AZD-5438; AZD 5438; 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine; CHEMBL488436; UNII-276Z913G29; MMV676604; 4-[2-METHYL-1-ISOPROPYL-1H-IMIDAZOL-5-YL]-N-[4-(METHYLSULFONYL)PHENYL]-2-PYRIMIDINAMINE; 2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-; 276Z913G29; 4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 371.5
Logarithm of the Partition Coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H21N5O2S
IUPAC Name
4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
Canonical SMILES
CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C
InChI
InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)
InChIKey
WJRRGYBTGDJBFX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
16747683
ChEBI ID
CHEBI:91419
CAS Number
602306-29-6
TTD ID
D06WHY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cyclin-dependent kinase 2 (CDK2) DTT CDK2 2.28E-06 0.12 0.19
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.1323 4.057 0.6978 30.0966
ES7 GDSC1; GDSC2 -0.3429 4.3514 -0.9995 39.2286
CHSA0108 GDSC1 -0.0792 1.9672 -0.1263 42.7295
EW-1 GDSC1; GDSC2 0.1344 3.3402 -0.1618 33.4086
ES1 GDSC1 0.2732 2.8992 0.0999 38.9959
A-673 GDSC1; GDSC2 0.3028 2.9802 0.1137 31.2417
HuO9 GDSC1; GDSC2 0.6658 3.1305 0.4732 27.6454
TC-71 GDSC1; GDSC2 0.7149 2.6312 0.6312 26.5899
EW-7 GDSC1; GDSC2 0.7677 2.3263 0.73 25.8231
ES4 GDSC1; GDSC2 1.2064 3.8129 0.8627 23.0628
CHSA8926 GDSC1; GDSC2 1.2882 3.7838 0.9611 22.1571
CAL-72 GDSC1; GDSC2 1.3188 4.486 0.736 23.2617
SK-PN-DW GDSC1; GDSC2 1.3725 3.4657 1.1535 20.7226
EW-13 GDSC1; GDSC2 1.3791 3.0141 1.2771 20.0254
CHSA0011 GDSC1 1.5925 7.3144 -0.2506 32.3291
EW-18 GDSC1; GDSC2 1.608 4.4892 1.0408 20.3264
EW-3 GDSC1; GDSC2 1.7507 3.9199 1.4135 17.6012
SK-ES-1 GDSC1; GDSC2 1.84 4.3731 1.3325 17.6881
ES8 GDSC1; GDSC2 1.8856 4.9437 1.1368 18.6398
SJSA-1 GDSC1 1.8948 4.6506 1.2736 22.1146
NOS-1 [Human HNSCC] GDSC1; GDSC2 1.9663 4.0235 1.6055 15.5866
ES5 GDSC1; GDSC2 2.0297 4.2285 1.5913 15.4046
MG-63 GDSC1; GDSC2 2.1375 9.548 -0.826 27.5049
NY GDSC1; GDSC2 2.2592 4.8358 1.5647 14.6522
HOS GDSC1; GDSC2 2.2663 5.9065 1.071 17.5735
SaOS-2 GDSC1; GDSC2 2.3041 5.9394 1.0915 17.3146
CADO-ES1 GDSC1; GDSC2 2.3669 6.0022 1.1214 16.9108
EW-22 GDSC1; GDSC2 2.4302 4.3984 1.9345 11.7753
HuO-3N1 GDSC1; GDSC2 2.6019 4.8304 1.9074 11.2945
MHH-ES-1 GDSC1; GDSC2 2.7157 4.4675 2.1894 9.1521
EW-16 GDSC2 2.9568 8.2652 0.5398 18.2546
G-292 clone A141B1 GDSC1; GDSC2 3.1325 9.4495 0.0989 20.0169
EW-11 GDSC1; GDSC2 3.2074 7.1077 1.3328 12.8619
CAL-78 GDSC1; GDSC2 3.2736 4.5293 2.6775 4.2231
ES6 GDSC1; GDSC2 3.4648 6.7537 1.7236 9.6944
U2OS GDSC1; GDSC2 3.6418 7.249 1.6182 9.8609
EW-24 GDSC1; GDSC2 3.6741 7.987 1.276 11.8632
H-EMC-SS GDSC1; GDSC2 4.199 7.2839 2.0157 6.0352
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 160 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 0.9229 2.2138 0.9034 30.1099
MOLM-16 GDSC1 -1.985 1.2474 -2.0627 64.0947
RS4;11 GDSC1; GDSC2 -1.5481 0.9349 -1.578 48.8979
SR GDSC1; GDSC2 -0.9527 1.0966 -0.9716 42.9706
SUP-M2 GDSC1; GDSC2 -0.8825 1.513 -0.9276 42.3651
MV4-11 GDSC1; GDSC2 -0.831 0.3739 -0.8316 41.6779
A3/Kawakami GDSC1; GDSC2 -0.7056 1.2415 -0.7242 40.4994
ST486 GDSC1; GDSC2 -0.6795 1.2556 -0.698 40.2379
BC-1 GDSC1; GDSC2 -0.5167 0.9594 -0.5211 38.5428
RPMI-8866 GDSC1; GDSC2 -0.4391 2.6451 -0.6196 38.5087
BL-41 GDSC1; GDSC2 -0.406 0.2114 -0.406 37.4098
697 GDSC1; GDSC2 -0.392 2.1723 -0.485 37.6902
DEL GDSC1; GDSC2 -0.3462 1.3034 -0.3575 36.8655
MOLM-13 GDSC1; GDSC2 -0.3453 0.697 -0.3457 36.8033
MC116 GDSC1 -0.3317 0.8704 -0.3331 45.6769
SU-DHL-6 GDSC1; GDSC2 -0.321 0.8038 -0.3218 36.5611
DoHH2 GDSC2 -0.2838 1.0012 -0.2862 36.1957
ML-2 GDSC1; GDSC2 -0.2591 1.7254 -0.2927 36.0985
A4/Fukuda GDSC1; GDSC2 -0.2522 1.0911 -0.2557 35.8845
SU-DHL-4 GDSC1 -0.236 1.3925 -0.248 44.5263
AMO1 GDSC1; GDSC2 -0.2355 1.1447 -0.2398 35.7206
Kasumi-1 GDSC1; GDSC2 -0.2172 1.5845 -0.2389 35.6218
P32/ISH GDSC1; GDSC2 -0.1997 0.9422 -0.2009 35.346
RCH-ACV GDSC1 -0.1061 1.5949 -0.1244 42.9395
CRO-AP2 GDSC1 -0.088 1.415 -0.0973 42.6724
SCC-3 GDSC2 -0.0756 5.8249 -1.2773 38.5528
JeKo-1 GDSC1 -0.0736 1.1274 -0.0758 42.4562
GA-10 GDSC1; GDSC2 -0.0244 1.1682 -0.0267 33.5921
JVM-3 GDSC1; GDSC2 -0.0179 2.2383 -0.0944 33.8904
Karpas-299 GDSC1 0.0125 2.0887 -0.0428 41.6366
NKM-1 GDSC1 0.0251 1.7695 0.0005 41.3392
L-363 GDSC1; GDSC2 0.0287 1.4433 0.021 33.0866
JVM-2 GDSC1; GDSC2 0.0393 2.1953 -0.0276 33.2721
MOLT-13 GDSC1; GDSC2 0.1026 1.9155 0.0699 32.4696
NALM-6 GDSC1; GDSC2 0.1489 2.2911 0.0764 32.2025
KMS-11 GDSC1 0.151 1.4749 0.1448 39.6726
U-698-M GDSC1; GDSC2 0.195 1.791 0.1757 31.476
SUP-B8 GDSC1 0.2135 1.755 0.197 38.9503
MEG-01 GDSC1; GDSC2 0.2182 3.2692 -0.051 32.4634
KY821 GDSC1; GDSC2 0.2281 1.7588 0.2119 31.1285
WSU-NHL GDSC1; GDSC2 0.255 1.919 0.2291 30.907
KE-37 GDSC1; GDSC2 0.2607 1.015 0.2606 30.7203
OCI-AML-2 GDSC1; GDSC2 0.3368 1.6776 0.3277 30.0017
MOLP-8 GDSC1; GDSC2 0.3852 1.2872 0.3846 29.4731
NB4 GDSC1 0.4098 1.4009 0.4084 36.4103
OCI-Ly7 GDSC1 0.4236 1.4859 0.4212 36.2443
MOLT-16 GDSC1; GDSC2 0.4263 1.6576 0.4199 29.0902
Mono-Mac-6 GDSC1 0.4509 3.947 -0.0019 38.1421
BE-13 GDSC1; GDSC2 0.4843 1.6949 0.4779 28.508
SU-DHL-16 GDSC1 0.4903 1.9734 0.4703 35.5172
NOMO-1 GDSC1; GDSC2 0.4919 4.7658 -0.2532 32.0022
KCL-22 GDSC1; GDSC2 0.4944 1.9816 0.4739 28.4782
CESS GDSC1; GDSC2 0.5068 2.3155 0.4547 28.5143
ALL-PO GDSC1; GDSC2 0.5195 2.6014 0.4258 28.5992
SU-DHL-5 GDSC1; GDSC2 0.5789 1.2784 0.5788 27.5267
P31/FUJ GDSC1 0.591 1.1523 0.591 34.1371
JSC-1 GDSC1; GDSC2 0.6366 2.2752 0.597 27.1483
THP-1 GDSC1 0.64 2.4341 0.581 33.8842
MM1.S GDSC2 0.6487 3.7538 0.2761 28.7375
KOPN-8 GDSC1; GDSC2 0.6511 1.4992 0.6503 26.806
YT GDSC1 0.6566 2.0338 0.639 33.4261
ATN-1 GDSC1; GDSC2 0.6999 2.5171 0.6332 26.6524
L-540 GDSC1; GDSC2 0.7375 2.6033 0.6602 26.33
NCI-H929 GDSC1; GDSC2 0.7583 1.6496 0.7568 25.7339
EoL-1 GDSC1; GDSC2 0.7797 2.19 0.7558 25.6325
QIMR-WIL GDSC1 0.7901 4.6607 0.1053 35.3747
CCRF-CEM GDSC1; GDSC2 0.8007 1.943 0.7926 25.3417
BALL-1 GDSC1; GDSC2 0.8167 2.1585 0.7968 25.2408
HDLM-2 GDSC1; GDSC2 0.8188 2.8137 0.7103 25.6774
TUR GDSC1; GDSC2 0.8308 3.0155 0.6804 25.7768
P30/OHK GDSC1; GDSC2 0.8477 2.0354 0.8367 24.8842
Loucy GDSC1; GDSC2 0.8652 1.6095 0.8648 24.6555
L-1236 GDSC1; GDSC2 0.8803 2.2401 0.8568 24.6209
CTV-1 GDSC1; GDSC2 0.8858 3.6968 0.5523 26.1933
BV-173 GDSC1; GDSC2 0.887 2.5698 0.8258 24.7476
Raji GDSC1; GDSC2 0.9487 2.7124 0.8693 24.223
EM-2 GDSC1; GDSC2 0.9668 5.1353 0.1014 28.1255
Reh GDSC1; GDSC2 0.9864 3.0468 0.8426 24.1835
Karpas-1106P GDSC1; GDSC2 0.992 2.0358 0.985 23.4159
Daudi GDSC1; GDSC2 1.0315 2.333 1.0072 23.1078
MHH-PREB-1 GDSC1; GDSC2 1.051 4.2262 0.5489 25.4554
KMOE-2 GDSC1; GDSC2 1.0755 3.8952 0.6929 24.5737
RPMI-8402 GDSC1 1.0874 4.0355 0.6569 30.6102
DND-41 GDSC1; GDSC2 1.0899 3.5132 0.8312 23.7625
Ramos.2G6.4C10 GDSC1; GDSC2 1.1008 3.2196 0.9251 23.2074
Karpas-231 GDSC1; GDSC2 1.1016 2.4735 1.0669 22.458
H9 GDSC1; GDSC2 1.1374 3.1695 0.9777 22.7561
Karpas-422 GDSC1; GDSC2 1.1425 3.0938 1.0016 22.6045
DB GDSC1; GDSC2 1.1636 5.4625 0.1677 26.9256
Jurkat GDSC1; GDSC2 1.1924 3.0349 1.0695 22.0085
OPM-2 GDSC1; GDSC2 1.2005 3.1958 1.0399 22.1285
EHEB GDSC1 1.2007 4.0546 0.7724 29.2369
HAL-01 GDSC1; GDSC2 1.2122 2.505 1.1804 21.3332
ALL-SIL GDSC1; GDSC2 1.2202 3.7071 0.9125 22.7286
IM-9 GDSC1; GDSC2 1.2363 2.8083 1.1627 21.3081
GDM-1 GDSC1; GDSC2 1.249 2.7872 1.1801 21.1563
OCI-AML-5 GDSC1; GDSC2 1.2709 2.5914 1.2325 20.7783
ARH-77 GDSC1; GDSC2 1.3235 4.2012 0.8506 22.6099
RPMI-6666 GDSC1; GDSC2 1.3767 3.0817 1.2595 20.1308
JURL-MK1 GDSC1; GDSC2 1.3926 3.8851 1.0396 21.2598
SKM-1 GDSC1; GDSC2 1.3972 2.0809 1.396 19.3209
Namalwa GDSC1; GDSC2 1.4199 2.8495 1.3535 19.429
PL-21 GDSC1 1.4239 3.41 1.2259 25.0174
CML-T1 GDSC1; GDSC2 1.4352 3.3541 1.254 19.8886
SK-MM-2 GDSC1; GDSC2 1.4458 3.577 1.1995 20.1393
HEL GDSC1; GDSC2 1.4556 3.4078 1.261 19.7577
U266B1 GDSC1; GDSC2 1.4602 3.8168 1.1363 20.4247
MLMA GDSC1; GDSC2 1.4653 2.8824 1.3965 18.9858
SU-DHL-10 GDSC1; GDSC2 1.4764 3.7229 1.1856 20.0791
RPMI-8226 GDSC1; GDSC2 1.4825 3.7588 1.1802 20.0816
MHH-CALL-2 GDSC1; GDSC2 1.4837 2.8095 1.4289 18.7276
LP-1 GDSC1; GDSC2 1.486 3.1373 1.3656 19.0516
HT GDSC1 1.4879 3.3933 1.3004 24.1518
VAL GDSC1; GDSC2 1.5102 3.5048 1.2919 19.3409
Karpas-620 GDSC1; GDSC2 1.5181 2.678 1.4846 18.2724
Farage GDSC1; GDSC2 1.5287 3.0209 1.4381 18.4652
SUP-HD1 GDSC1; GDSC2 1.541 3.7183 1.2573 19.3939
SUP-T1 GDSC1; GDSC2 1.5484 3.4177 1.3595 18.7971
Ku812 GDSC1; GDSC2 1.5559 2.9263 1.4864 18.0804
LC4-1 GDSC1; GDSC2 1.5752 2.9483 1.5031 17.9008
Jiyoye GDSC1; GDSC2 1.6046 3.4535 1.4102 18.265
P12-Ichikawa GDSC1; GDSC2 1.6137 3.3704 1.4443 18.037
HC-1 GDSC1; GDSC2 1.6502 4.884 0.92 20.8368
OCI-AML-3 GDSC1; GDSC2 1.6503 2.7062 1.6215 16.9214
OCI-Ly19 GDSC1 1.6798 3.2422 1.551 21.3672
NU-DUL-1 GDSC1 1.6979 3.0701 1.6114 20.8594
KG-1 GDSC1; GDSC2 1.7028 3.3569 1.5453 17.0795
DG-75 GDSC1; GDSC2 1.7339 4.7587 1.0604 19.6929
ME1 GDSC1; GDSC2 1.7458 3.2363 1.6244 16.4527
OCI-M1 GDSC1; GDSC2 1.8445 4.0454 1.4671 16.8947
Sc-1 GDSC1 1.9108 3.9282 1.5823 19.8659
JJN-3 GDSC1; GDSC2 1.9565 3.3747 1.817 14.4397
VL51 GDSC1; GDSC2 1.9894 4.7264 1.3386 17.0473
Karpas-45 GDSC1; GDSC2 2.0592 3.2193 1.9705 13.1353
WIL2 NS GDSC1; GDSC2 2.1003 3.6391 1.8903 13.3915
HH [Human lymphoma] GDSC1; GDSC2 2.1696 3.8468 1.8903 13.0927
KMS-12-BM GDSC2 2.1828 3.1877 2.1127 11.7963
EJM GDSC1; GDSC2 2.2283 3.7707 1.9816 12.3207
TK [Human B-cell lymphoma] GDSC1; GDSC2 2.2942 3.508 2.1445 11.1155
CMK GDSC1 2.2968 5.5273 1.2807 20.0812
CA46 GDSC1; GDSC2 2.3098 4.9346 1.5703 14.426
SUP-B15 GDSC2 2.3216 4.1925 1.912 12.3382
HL-60 GDSC1; GDSC2 2.3559 3.2645 2.2828 10.0771
RC-K8 GDSC1; GDSC2 2.4713 4.6706 1.8528 12.11
EB2 GDSC1; GDSC2 2.4879 5 1.716 12.8803
LAMA-84 GDSC1; GDSC2 2.5129 5.3544 1.5721 13.6684
KM-H2 GDSC1; GDSC2 2.5529 3.8827 2.2833 9.2191
L-428 GDSC1; GDSC2 2.7099 4.5608 2.14 9.4757
Hs 445 GDSC1; GDSC2 2.8157 4.2614 2.3843 7.5936
CTB-1 GDSC1 2.8558 5.1125 2.0137 12.131
PF-382 GDSC1; GDSC2 2.8772 4.4851 2.3381 7.6552
MN-60 GDSC1; GDSC2 2.9317 4.372 2.4445 6.8046
K-562 GDSC1; GDSC2 3.007 4.9123 2.2511 7.7546
GR-ST GDSC1; GDSC2 3.0831 5.0282 2.2624 7.4366
WSU-DLCL2 GDSC1 3.1689 5.5618 2.072 10.4162
SU-DHL-8 GDSC1; GDSC2 3.4965 5.4174 2.4159 5.2485
RL GDSC1 3.5223 7.8164 1.2394 15.3477
Granta-519 GDSC1; GDSC2 3.5386 5.5773 2.3693 5.4298
MOLT-4 GDSC1; GDSC2 3.9631 6.2006 2.3756 4.3642
ROS-50 GDSC1 4.6927 10.5277 0.7877 14.5756
⏷ Show the Full List of 160 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -0.7452 4.9128 -1.634 50.5464
KYSE-220 GDSC1; GDSC2 0.8883 3.1838 0.7025 25.3878
ESO-26 GDSC1; GDSC2 1.0772 3.2134 0.9009 23.4473
OACM5.1 C GDSC1; GDSC2 1.3461 3.7407 1.0383 21.4735
FLO-1 GDSC1; GDSC2 1.3678 3.7433 1.061 21.2513
TE-12 GDSC1; GDSC2 2.2243 5.7886 1.0865 17.6363
KYSE-50 GDSC1; GDSC2 2.9067 5.6879 1.7772 11.0517
KYAE-1 GDSC1; GDSC2 3.0221 7.8554 0.8007 16.5859
ESO-51 GDSC1; GDSC2 3.2939 8.7599 0.5796 16.9891
OACP4 C GDSC1; GDSC2 3.3683 5.5561 2.2433 6.6955
SK-GT-4 GDSC1; GDSC2 3.4456 7.4457 1.3622 11.9819
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 2.2755 5.8708 1.0968 17.3875
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC1 0.0636 8.4349 -2.281 45.5471
SJNB-5 GDSC1 0.5013 2.335 0.4463 35.5865
SJNB-7 GDSC1; GDSC2 0.5143 4.0416 0.035 30.5731
CHP-126 GDSC1 0.9199 3.7637 0.5678 32.1624
SJNB-14 GDSC1; GDSC2 1.1206 3.64 0.8257 23.652
NB1 GDSC1 1.249 3.0004 1.1386 26.6194
SK-N-MC-IXC GDSC1 1.2682 2.7083 1.2134 26.02
SJNB-10 GDSC1; GDSC2 1.2694 3.3053 1.0865 21.5583
SK-N-SH GDSC1 1.3994 3.6797 1.1163 25.8842
TGW GDSC1; GDSC2 1.4562 3.923 1.095 20.672
SJNB-13 GDSC1; GDSC2 1.5273 3.3838 1.3461 18.9668
Kelly GDSC1; GDSC2 1.5959 3.4375 1.4054 18.3305
IMR-5 GDSC1; GDSC2 1.6069 4.5165 1.0285 20.4006
CHP-212 GDSC1; GDSC2 1.6165 4.0567 1.2187 19.2811
NB69 GDSC1; GDSC2 1.6239 3.9772 1.2561 19.0379
SJNB-17 GDSC1 1.6627 3.4007 1.489 21.882
GOTO GDSC1; GDSC2 1.8322 4.7475 1.1672 18.678
NH-12 GDSC1; GDSC2 2.0515 6.1511 0.7468 20.2407
SK-N-DZ GDSC1; GDSC2 2.0717 4.3037 1.6044 15.1565
SK-N-BE(2)-M17 GDSC1; GDSC2 2.2519 4.5005 1.707 13.8297
SJNB-6 GDSC1 2.5885 4.0223 2.2617 11.4629
SK-N-FI GDSC1 2.7026 5.0534 1.8981 13.6804
SK-N-AS GDSC1; GDSC2 2.8199 3.9637 2.5248 6.7256
GI-ME-N GDSC1; GDSC2 2.8721 6.351 1.4179 13.3913
KP-N-YN GDSC1; GDSC2 2.9857 7.5917 0.9008 16.1241
NB(TU)1 GDSC1; GDSC2 3.3506 5.5292 2.2421 6.7532
SiMa GDSC1; GDSC2 3.4729 8.3362 0.9394 14.4228
LA-N-6 GDSC1 3.5035 5.7455 2.2579 7.7522
CHP-134 GDSC2 4.3794 12.9519 -0.6427 19.9354
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 1.4177 3.7908 1.0992 20.8181
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1; GDSC2 0.0671 2.6685 -0.0755 33.3586
HCC1187 GDSC1; GDSC2 0.1078 1.7394 0.0885 32.3504
DU4475 GDSC1; GDSC2 0.292 2.576 0.185 30.9431
Hs 578T GDSC1; GDSC2 0.4827 5.0403 -0.3704 32.5496
MRK-nu-1 GDSC1; GDSC2 0.7697 1.5769 0.769 25.6158
HCC70 GDSC1; GDSC2 0.928 3.173 0.7484 24.9577
MDA-MB-468 GDSC1; GDSC2 1.1012 2.458 1.0683 22.4524
MDA-MB-231 GDSC1; GDSC2 1.1207 3.6645 0.8181 23.6929
HCC1395 GDSC1 1.2498 3.8884 0.8839 28.2542
HCC2157 GDSC1; GDSC2 1.2785 3.1688 1.1317 21.2729
HCC1599 GDSC1 1.3304 8.012 -0.8361 35.8618
MDA-MB-157 GDSC1; GDSC2 1.3754 3.4592 1.1586 20.6818
HCC1954 GDSC1; GDSC2 1.4151 4.0176 1.0167 21.2883
HCC202 GDSC1 1.6726 5.4954 0.6742 27.1814
MCF-7 GDSC1; GDSC2 1.6895 5.2484 0.8017 21.3443
HDQ-P1 GDSC1; GDSC2 1.8116 5.6553 0.7416 21.1945
HCC1569 GDSC1; GDSC2 1.8451 6.0642 0.5857 21.9268
HCC1806 GDSC1; GDSC2 1.9259 3.9063 1.6067 15.7512
COLO 824 GDSC1; GDSC2 2.0421 3.8276 1.7605 14.3777
AU565 GDSC1; GDSC2 2.2185 3.9944 1.8851 12.9168
CAL-85-1 GDSC1; GDSC2 2.274 5.0858 1.4648 15.1955
MDA-MB-361 GDSC1; GDSC2 2.3014 4.1878 1.8929 12.5322
BT-20 GDSC1; GDSC2 2.3211 4.2038 1.9067 12.3715
OCUB-M GDSC1; GDSC2 2.4532 5.2017 1.587 13.7934
HCC2218 GDSC1 2.5485 5.9124 1.3367 18.5334
JIMT-1 GDSC1; GDSC2 2.5975 6.0998 1.2911 15.0834
CAL-120 GDSC1; GDSC2 2.7324 5.7402 1.5921 12.7812
MDA-MB-330 GDSC1; GDSC2 2.9014 4.3175 2.4414 6.9313
Evsa-T GDSC1; GDSC2 2.9436 4.6328 2.3296 7.4769
BT-549 GDSC1; GDSC2 2.9688 8.1106 0.6273 17.733
MFM-223 GDSC1; GDSC2 3.0984 5.7554 1.9142 9.5807
HCC1143 GDSC1; GDSC2 3.1165 7.2003 1.2089 13.8904
MDA-MB-453 GDSC1; GDSC2 3.1358 6.3125 1.6689 11.0033
BT-474 GDSC1; GDSC2 3.1611 4.545 2.5716 5.2398
MDA-MB-415 GDSC1; GDSC2 3.1698 4.8818 2.4118 6.2205
HCC1937 GDSC1; GDSC2 3.2169 8.5331 0.6284 16.953
EFM-192A GDSC1; GDSC2 3.2262 6.8323 1.4864 11.8628
CAMA-1 GDSC1; GDSC2 3.3146 4.8475 2.553 4.8899
EFM-19 GDSC1; GDSC2 3.3654 7.8581 1.09 13.8527
HCC1419 GDSC1; GDSC2 3.4215 5.2135 2.4578 5.1889
HCC38 GDSC1; GDSC2 3.507 6.3262 1.9711 8.0246
ZR-75-30 GDSC1; GDSC2 3.5684 5.2509 2.5543 4.1888
MDA-MB-436 GDSC1; GDSC2 3.5959 12.0424 -0.8121 22.7896
BT-483 GDSC1 3.6185 5.3041 2.5658 4.9714
UACC-893 GDSC1 3.6321 14.3794 -1.9505 30.2039
MDA-MB-175-VII GDSC1 3.6531 5.8467 2.3238 6.7483
HCC1500 GDSC1; GDSC2 3.8905 6.0431 2.4012 4.3694
HCC1428 GDSC1; GDSC2 3.9532 6.1998 2.3691 4.4254
T-47D GDSC1; GDSC2 4.0589 14.2288 -1.5302 24.2577
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 -0.895 3.8965 -1.449 51.9642
MOG-G-UVW GDSC1 -0.4234 2.0646 -0.5035 46.9994
LNZTA3WT4 GDSC1 -0.2038 3.5639 -0.5945 45.1303
SF126 GDSC1 0.3249 3.4251 0.0224 38.9533
SF539 GDSC1; GDSC2 0.4319 3.8596 0.0063 31.1155
YKG-1 GDSC1 0.6486 4.6465 -0.0402 36.941
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 0.6859 3.5171 0.3895 27.9815
D-423MG GDSC1 0.7014 4.9746 -0.1127 36.8901
YH-13 GDSC1; GDSC2 0.7024 5.5895 -0.365 31.4732
MOG-G-CCM GDSC1 0.9354 5.6619 -0.1541 35.5858
SW1783 GDSC1 1.0848 6.019 -0.1572 34.709
SK-MG-1 GDSC1; GDSC2 1.1157 3.59 0.836 23.6182
T98G GDSC1; GDSC2 1.1483 4.2103 0.6593 24.428
NMC-G1 GDSC1 1.2148 4.2442 0.718 29.4838
Onda 10 GDSC1 1.217 4.8107 0.4978 30.7478
A-172 GDSC1; GDSC2 1.225 2.7605 1.1587 21.3831
SNB-75 GDSC1 1.3506 5.4383 0.3709 30.6687
D283 Med GDSC1; GDSC2 1.3864 4.5084 0.7988 22.6241
PFSK-1 GDSC1; GDSC2 1.4207 3.3652 1.2351 20.0582
GI-1 GDSC1; GDSC2 1.6121 4.2882 1.1254 19.8289
H4 GDSC1; GDSC2 1.6459 3.4265 1.4633 17.7866
Hs 683 GDSC1 1.6593 5.6899 0.5729 27.8502
SF295 GDSC1 1.6695 7.119 -0.0832 31.1958
D-336MG GDSC1 1.6874 4.7963 0.9961 25.0792
D-392MG GDSC1; GDSC2 1.7313 4.0727 1.3357 18.1263
Onda 11 GDSC1 1.7336 6.6519 0.2003 29.4953
KNS-81-FD GDSC1 1.7341 7.5709 -0.237 31.5565
D-247MG GDSC1 1.8067 4.8601 1.0923 23.8105
D-502MG GDSC1 1.8171 7.4958 -0.1216 30.6317
LN-18 GDSC1; GDSC2 1.8741 6.9587 0.1907 23.9011
KNS-42 GDSC1 1.9653 4.774 1.293 21.6177
ONS-76 GDSC1; GDSC2 2.0883 4.7567 1.4267 16.1363
DK-MG GDSC1; GDSC2 2.1042 4.4007 1.5976 15.0646
GaMG GDSC1; GDSC2 2.1396 5.9436 0.9307 18.8603
D-542MG GDSC1 2.1727 5.2226 1.301 20.5311
Daoy GDSC1; GDSC2 2.2388 4.4858 1.7001 13.9224
42-MG-BA GDSC1; GDSC2 2.2957 4.8511 1.5944 14.3344
8-MG-BA GDSC1; GDSC2 2.4166 4.9203 1.6831 13.3438
Becker GDSC1; GDSC2 2.573 6.0299 1.3025 15.099
M059J GDSC1; GDSC2 2.6393 5.3297 1.7047 12.4069
U-251MG GDSC1; GDSC2 2.6594 5.014 1.8758 11.2818
CAS-1 GDSC1; GDSC2 2.7671 6.1299 1.4324 13.6479
U-87MG ATCC GDSC1; GDSC2 2.772 4.5523 2.2046 8.8541
D-263MG GDSC1; GDSC2 2.7965 3.9803 2.4937 7.0026
SF268 GDSC1; GDSC2 2.8791 7.6324 0.7874 17.1185
U-118MG GDSC1; GDSC2 2.9485 6.7503 1.2874 13.9425
SW1088 GDSC1; GDSC2 3.0336 4.5631 2.4472 6.4375
AM-38 GDSC1; GDSC2 3.047 6.5067 1.495 12.3586
LN-405 GDSC1; GDSC2 3.0508 6.8073 1.3485 13.247
LN-229 GDSC1; GDSC2 3.1496 4.2604 2.7023 4.4547
DBTRG-05MG GDSC1; GDSC2 3.2346 4.4404 2.6883 4.2729
GB-1 GDSC1; GDSC2 3.2924 9.1566 0.3799 18.0738
KINGS-1 GDSC1; GDSC2 3.6022 6.2086 2.1051 6.9252
KALS-1 GDSC1; GDSC2 3.6701 8.4508 1.0416 13.2672
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 1.2456 3.4934 1.0069 27.4942
ETK-1 GDSC1; GDSC2 3.0161 5.8613 1.7892 10.6243
TGBC24TKB GDSC1; GDSC2 3.2776 5.7666 2.0624 8.1026
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2 1.0845 3.6707 0.7767 24.0812
ESS-1 GDSC1; GDSC2 1.387 4.4468 0.8238 22.483
RL95-2 GDSC1; GDSC2 1.507 3.4489 1.3051 19.2827
MFE-280 GDSC1; GDSC2 2.1213 5.059 1.3245 16.6144
MFE-296 GDSC1; GDSC2 2.4149 4.9539 1.6657 13.4555
EN GDSC1; GDSC2 2.8045 4.7524 2.1401 9.1363
MFE-319 GDSC1; GDSC2 3.1336 4.5163 2.5613 5.3931
KLE GDSC1; GDSC2 3.5121 9.9555 0.1623 18.5512
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1 -2.0583 2.8251 -2.4218 62.1653
UO-31 GDSC1 -1.4657 2.2807 -1.66 58.079
LB1047-RCC GDSC1 -1.4388 4.1612 -2.1248 56.2057
KTCTL-26A GDSC1 -1.3089 4.9173 -2.2425 54.7823
KTCTL-13 GDSC1 -0.4198 2.9189 -0.659 47.2066
KTCTL-140 GDSC1 -0.2195 3.8013 -0.6838 45.4349
KMRC-1 GDSC1 -0.1839 3.6978 -0.613 44.997
LB996-RCC GDSC1; GDSC2 -0.0333 3.0125 -0.2602 34.7373
Caki-1 GDSC1 0.0188 7.8515 -2.0602 45.5786
KTCTL-195 GDSC1; GDSC2 0.0668 2.1896 0.0024 32.9846
BB65-RCC GDSC1 0.1001 3.9849 -0.3952 42.1501
KTCTL-1M GDSC1 0.3945 5.2144 -0.5335 40.4128
NCC010 GDSC1; GDSC2 0.5798 3.1796 0.367 28.6067
769-P GDSC1; GDSC2 1.0065 4.6887 0.3244 26.8295
ACHN GDSC1; GDSC2 1.0373 6.1224 -0.2516 29.4568
NCC021 GDSC1 1.0852 13.1142 -3.5438 42.346
SW156 GDSC1 1.125 5.3515 0.1754 32.9722
KTCTL-21 GDSC1 1.2004 5.8083 0.0542 33.107
RXF 393L GDSC1; GDSC2 1.2851 6.565 -0.2021 28.1642
CAL-54 GDSC1; GDSC2 1.2928 7.0277 -0.4087 29.0438
A-704 GDSC1; GDSC2 1.5275 3.3732 1.3493 18.9482
786-O GDSC1; GDSC2 1.5291 3.9211 1.1743 19.9102
A-498 GDSC1; GDSC2 1.6033 4.726 0.9382 20.9277
BFTC-909 GDSC1; GDSC2 1.731 4.0349 1.3497 18.0476
HA7-RCC GDSC1; GDSC2 1.8107 6.0044 0.5795 22.095
SW13 GDSC1; GDSC2 2.2299 3.6139 2.0394 11.9865
OS-RC-2 GDSC1; GDSC2 2.9353 5.9186 1.6888 11.5099
TK-10 GDSC1; GDSC2 2.9443 7.8353 0.7433 17.1598
KMRC-20 GDSC1; GDSC2 3.0176 4.8116 2.3104 7.3477
SN12C GDSC1; GDSC2 3.0416 7.2937 1.0979 14.7885
RCC10RGB GDSC1; GDSC2 3.3481 8.3188 0.8452 15.3326
VMRC-RCZ GDSC1; GDSC2 3.4767 6.7088 1.7557 9.4601
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1; GDSC2 0.0347 1.7222 0.0138 33.0919
SW620 GDSC1; GDSC2 0.4374 2.9124 0.2756 29.7664
SNU-C5 GDSC1; GDSC2 0.5112 2.2369 0.4685 28.422
LS513 GDSC1; GDSC2 0.5701 4.534 -0.0816 30.8496
HT115 GDSC1; GDSC2 0.7942 3.8561 0.401 27.4109
MDST8 GDSC1; GDSC2 0.9763 4.0242 0.5409 25.8369
SNU-C1 GDSC1; GDSC2 0.9915 6.0921 -0.2848 29.8064
SW48 GDSC1; GDSC2 1.2356 5.9806 0.0134 27.3683
GP5d GDSC1; GDSC2 1.3357 2.5969 1.3007 20.1106
HCT 15 GDSC1; GDSC2 1.3634 4.056 0.9471 21.9017
RKO GDSC1; GDSC2 1.4674 3.8253 1.1412 20.3654
LS1034 GDSC1; GDSC2 1.4867 5.1471 0.6377 23.0872
HT-55 GDSC1; GDSC2 1.5822 3.4624 1.3832 18.5143
CCK-81 GDSC1; GDSC2 1.585 3.2816 1.4372 18.2069
RCM-1 [Human ESC] GDSC1; GDSC2 1.6048 5.1707 0.7491 21.984
DiFi GDSC1; GDSC2 1.6559 3.7887 1.3578 18.3272
LS411N GDSC1; GDSC2 1.7004 4.2886 1.219 18.9229
HCC2998 GDSC1; GDSC2 1.8465 4.8755 1.1265 18.8557
SNU-407 GDSC1; GDSC2 1.9013 4.4347 1.3714 17.2107
COLO 320HSR GDSC1; GDSC2 1.9176 3.3825 1.7723 14.8612
CW-2 GDSC1; GDSC2 1.9766 4.2003 1.5466 15.8837
NCI-H716 GDSC1; GDSC2 2.0187 5.2721 1.1243 18.1905
NCI-H508 GDSC1 2.2025 6.2692 0.8361 23.5195
SW626 GDSC1; GDSC2 2.222 5.6538 1.148 17.2819
SW1463 GDSC1; GDSC2 2.3026 5.9304 1.0944 17.3029
T84 GDSC1; GDSC2 2.3133 5.285 1.4109 15.3732
LS180 GDSC1; GDSC2 2.5538 5.1332 1.717 12.6351
SNU-C2B GDSC1; GDSC2 2.6718 7.7388 0.5507 19.128
HT-29 GDSC1; GDSC2 2.7188 5.0211 1.9291 10.743
SNU-175 GDSC2 2.7936 7.5501 0.7529 17.5937
C2BBe1 GDSC1; GDSC2 2.8522 5.4879 1.8263 10.9254
LoVo GDSC1; GDSC2 2.8739 5.7913 1.6965 11.662
SW948 GDSC1; GDSC2 3.0046 10.8473 -0.7084 24.1323
SNU-81 GDSC1; GDSC2 3.0304 4.6708 2.3914 6.798
COLO205 GDSC1; GDSC2 3.0619 6.7377 1.3928 12.941
LS123 GDSC1; GDSC2 3.111 7.5206 1.0443 14.8905
SK-CO-1 GDSC1; GDSC2 3.1335 8.5811 0.5337 17.7314
NCI-H747 GDSC1; GDSC2 3.1746 6.6758 1.5207 11.8067
SNU-1040 GDSC1; GDSC2 3.2066 5.8146 1.9782 8.8458
CL-11 GDSC1; GDSC2 3.2556 7.4208 1.217 13.4189
SW1116 GDSC1; GDSC2 3.2683 6.9746 1.4507 11.957
COLO 678 GDSC1; GDSC2 3.3311 5.227 2.3771 5.9556
CaR-1 GDSC1; GDSC2 3.4591 6.8159 1.6879 9.9331
SW1417 GDSC1; GDSC2 3.537 5.5421 2.3856 5.3313
SW837 GDSC1; GDSC2 3.5479 6.4177 1.958 7.9952
SNU-61 GDSC1; GDSC2 3.9926 7.9275 1.5514 9.3573
KM12 GDSC1; GDSC2 5.7486 7.2709 2.8313 0.2064
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.6916 6.3408 2.1085 6.6708
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1; GDSC2 -0.3387 2.5431 -0.4905 37.4111
HLE GDSC1; GDSC2 0.9525 3.8818 0.5641 25.8229
SNU-449 GDSC1; GDSC2 1.0863 4.7297 0.3927 26.1197
JHH-1 GDSC1; GDSC2 1.0919 2.9161 0.9858 22.9276
SK-HEP-1 GDSC1; GDSC2 1.68 3.7915 1.3829 18.0806
JHH-6 GDSC1; GDSC2 1.7489 7.8297 -0.3474 26.9419
SNU-387 GDSC1; GDSC2 1.8083 4.6007 1.2048 18.5576
Hep 3B2.1-7 GDSC1; GDSC2 2.109 7.2772 0.2606 22.6588
SNU-423 GDSC1; GDSC2 2.2143 4.3894 1.7166 13.9218
JHH-2 GDSC1; GDSC2 2.2164 9.1593 -0.5625 26.1442
JHH-4 GDSC1; GDSC2 2.2651 6.4843 0.7921 19.1951
HuH-1 GDSC1; GDSC2 2.7166 5.7229 1.5859 12.8732
JHH-7 GDSC1; GDSC2 3.1808 5.6731 2.0268 8.6178
Hep-G2/C3A GDSC1; GDSC2 3.1998 6.5394 1.6104 11.1735
Huh-7 GDSC1; GDSC2 3.2746 6.2215 1.8325 9.5602
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H647 GDSC1 -0.9364 2.0491 -1.0498 52.9042
NCI-H2030 GDSC1 -0.7272 2.6821 -0.9402 50.5279
NCI-H1648 GDSC1 -0.3224 3.3768 -0.6704 46.3147
CAL-12T GDSC1 -0.2746 3.336 -0.6069 45.7754
SBC-3 GDSC1; GDSC2 -0.2594 1.9464 -0.3145 36.202
NCI-H358 GDSC1; GDSC2 -0.2118 2.7552 -0.3958 36.3007
NCI-H290 GDSC1 -0.1815 1.4737 -0.1958 43.8588
NCI-H524 GDSC1; GDSC2 -0.1491 3.9131 -0.6426 36.9283
NCI-H1341 GDSC1 -0.0378 3.4705 -0.3862 43.2302
NCI-H2009 GDSC1 -0.0285 5.7581 -1.2004 44.8132
NCI-H2122 GDSC1; GDSC2 0.1256 2.7679 -0.0321 32.8494
RERF-LC-MS GDSC1 0.2964 3.6856 -0.086 39.6054
NCI-H460 GDSC1 0.3652 2.886 0.2029 37.8332
NCI-H847 GDSC1 0.4436 3.1786 0.2187 37.1957
SBC-1 GDSC1 0.4659 3.5143 0.1504 37.3636
EMC-BAC-2 GDSC1; GDSC2 0.4765 4.1425 -0.0407 31.1163
LCLC-97TM1 GDSC1; GDSC2 0.522 4.8899 -0.2695 31.9262
NCI-H838 GDSC1 0.5876 3.456 0.3002 35.7877
NCI-H2170 GDSC1; GDSC2 0.6597 4.0901 0.1757 29.1865
LC-2/ad GDSC1 0.7126 5.3959 -0.2731 37.4393
NCI-H1435 GDSC1; GDSC2 0.8211 2.551 0.7579 25.4188
A-549 GDSC1; GDSC2 0.8357 5.0905 -0.0178 29.296
NCI-H146 GDSC1 0.9292 5.7511 -0.1991 35.8052
EPLC-272H GDSC1; GDSC2 0.9509 2.8496 0.8464 24.3324
NCI-H211 GDSC1; GDSC2 0.9554 3.0094 0.8174 24.4635
NCI-H2804 GDSC1; GDSC2 0.9808 3.0587 0.8337 24.2573
NCI-H1703 GDSC1 1.0058 3.6961 0.683 30.9545
NCI-H2347 GDSC1 1.061 4.2235 0.5606 31.329
NCI-H1838 GDSC1 1.0765 5.4168 0.0972 33.6333
NCI-H1573 GDSC1 1.0827 3.3857 0.8604 29.3997
NCI-H2795 GDSC1; GDSC2 1.0842 2.0683 1.0782 22.4863
NCI-H1944 GDSC1; GDSC2 1.0912 3.0625 0.9531 23.1035
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 1.124 4.104 0.6719 24.4686
NCI-H292 GDSC1 1.1253 2.7376 1.0552 27.9028
NCI-H2023 GDSC1; GDSC2 1.1462 4.2512 0.6418 24.532
NCI-H1975 GDSC1; GDSC2 1.1633 5.7554 0.0396 27.5546
EBC-1 GDSC1; GDSC2 1.1695 6.9572 -0.4981 29.9419
IST-SL1 GDSC1 1.1814 3.4021 0.9636 28.153
NCI-H23 GDSC1; GDSC2 1.2001 3.9296 0.8158 23.3469
NCI-H1915 GDSC1; GDSC2 1.2079 4.1524 0.7446 23.7008
DMS 273 GDSC1; GDSC2 1.2178 7.7433 -0.818 31.0066
NCI-H209 GDSC1; GDSC2 1.2244 3.4372 1.0004 22.2309
NCI-H526 GDSC1; GDSC2 1.2357 4.1273 0.7837 23.3637
NCI-H2342 GDSC1 1.2371 6.6171 -0.274 34.3212
NCI-H3122 GDSC1; GDSC2 1.2528 5.1417 0.3975 25.3647
NCI-H82 GDSC1; GDSC2 1.2545 3.9353 0.8728 22.7923
A-427 GDSC1; GDSC2 1.2722 4.0685 0.8444 22.8701
NCI-H1437 GDSC1 1.2732 3.2172 1.1138 26.6364
COR-L311 GDSC2 1.2969 3.6303 1.0207 21.7909
COR-L279 GDSC1 1.3279 3.4925 1.0969 26.4258
NCI-H1792 GDSC1; GDSC2 1.3481 2.8155 1.2819 20.1478
NCI-H2444 GDSC1 1.412 5.9506 0.2055 31.1809
EMC-BAC-1 GDSC1 1.4438 4.4662 0.8764 27.1863
Lu-134-A GDSC1 1.4479 5.0929 0.621 28.721
SHP-77 GDSC1; GDSC2 1.4563 3.5898 1.2069 20.0508
HOP-62 GDSC1; GDSC2 1.4741 4.8357 0.7572 22.4815
LK-2 GDSC1; GDSC2 1.5123 7.125 -0.2389 27.3925
NCI-H2110 GDSC1 1.515 4.7603 0.8315 27.0714
NCI-H1105 GDSC1 1.5277 3.0694 1.4266 23.0811
NCI-H446 GDSC1; GDSC2 1.6213 3.6434 1.3692 18.4162
LXF 289 GDSC1; GDSC2 1.625 4.4216 1.0861 19.9976
KNS-62 GDSC1; GDSC2 1.628 6.2614 0.2792 24.4158
RERF-LC-Sq1 GDSC1; GDSC2 1.6327 5.5709 0.5999 22.6934
NCI-H1155 GDSC1; GDSC2 1.6636 4.4469 1.1166 19.6621
NCI-H226 GDSC1; GDSC2 1.694 6.8531 0.0667 25.2219
ChaGo-K-1 GDSC1 1.7061 3.4951 1.5084 21.5041
PaCa-3 GDSC1 1.7371 4.9525 0.9804 24.9175
NCI-H1568 GDSC1; GDSC2 1.8147 5.8673 0.6471 21.7083
HCC44 GDSC1; GDSC2 1.8201 6.0201 0.5815 22.0475
RERF-LC-KJ GDSC1; GDSC2 1.8236 3.9533 1.4795 16.9136
NCI-H2085 GDSC1; GDSC2 1.8358 6.7866 0.2358 23.8189
NCI-H2461 GDSC1; GDSC2 1.8407 4.6946 1.1987 18.4608
NCI-H1299 GDSC1; GDSC2 1.9159 4.3944 1.4035 16.9642
UMC-11 GDSC1; GDSC2 1.9171 3.8821 1.6061 15.7923
SBC-5 GDSC1; GDSC2 1.9751 3.7523 1.7156 14.9217
NCI-H810 GDSC1; GDSC2 1.9866 3.4534 1.8267 14.2505
COR-L32 GDSC1 2.0354 7.6073 0.0311 28.8522
NCI-H1563 GDSC1; GDSC2 2.0669 3.6892 1.8369 13.8381
NCI-H661 GDSC1; GDSC2 2.0853 5.5005 1.0856 18.1622
NCI-H1963 GDSC2 2.0998 4.6389 1.4903 15.7153
Ms-1 GDSC1; GDSC2 2.1261 3.5611 1.9445 12.9748
LB647-SCLC GDSC1 2.1749 5.1887 1.3188 20.3944
CPC-N GDSC1; GDSC2 2.1897 4.9051 1.4632 15.5257
Lu-139 GDSC1; GDSC2 2.2264 5.5434 1.2044 16.9313
COR-L321 GDSC1 2.293 3.6873 2.0817 14.2918
NCI-H2172 GDSC1 2.2959 5.5889 1.2506 20.2975
NCI-H1581 GDSC1; GDSC2 2.3738 3.602 2.1991 10.4593
VMRC-LCD GDSC1; GDSC2 2.3812 5.7361 1.2629 16.0153
Lu-135 GDSC1; GDSC2 2.3936 7.0735 0.6257 19.6716
NCI-H3255 GDSC1; GDSC2 2.4093 8.3333 0.0202 22.7926
NCI-H69 GDSC1 2.4393 4.2763 1.9977 14.151
HCC78 GDSC1; GDSC2 2.4601 7.9565 0.2524 21.4436
Calu-3 GDSC1; GDSC2 2.4626 5.9989 1.2138 16.0192
NCI-H1869 GDSC1; GDSC2 2.5004 5.0781 1.6914 12.9851
NCI-H1876 GDSC1; GDSC2 2.5143 4.7984 1.8364 12.0491
LCLC-103H GDSC1; GDSC2 2.5268 4.5596 1.9592 11.2568
HCC827 GDSC1; GDSC2 2.527 4.0229 2.1976 9.8278
SW1271 GDSC1; GDSC2 2.5381 6.2155 1.1793 15.9612
NCI-H2291 GDSC1 2.5551 7.1187 0.7519 22.442
NCI-H596 GDSC1; GDSC2 2.5596 3.8847 2.2895 9.1558
NCI-H1770 GDSC1 2.582 6.499 1.0813 20.1704
NCI-H1993 GDSC1; GDSC2 2.5825 4.615 1.9892 10.8661
SK-MES-1 GDSC1; GDSC2 2.5836 5.734 1.4563 14.1267
NCI-H1048 GDSC1; GDSC2 2.5935 3.9224 2.3094 8.9014
NCI-H1651 GDSC1; GDSC2 2.6014 5.3054 1.6804 12.6902
Lu-99A GDSC1; GDSC2 2.6383 6.9477 0.9119 17.1975
HCC366 GDSC1; GDSC2 2.6446 5.8527 1.4557 13.9195
EKVX GDSC1; GDSC2 2.6799 6.6634 1.0901 16.0095
PC-14 GDSC1; GDSC2 2.6814 4.4222 2.1766 9.3578
COR-L23 GDSC1; GDSC2 2.6997 7.1823 0.8515 17.3405
NCI-H1755 GDSC1; GDSC2 2.7067 6.0658 1.4087 13.9953
LC-1/sq GDSC1; GDSC2 2.7181 5.2233 1.8308 11.3538
NCI-H1666 GDSC1; GDSC2 2.7445 5.7138 1.6163 12.5911
LOU-NH91 GDSC1; GDSC2 2.7721 6.1645 1.42 13.7074
DMS 114 GDSC1; GDSC2 2.8388 7.513 0.8113 17.1129
COLO 668 GDSC1; GDSC2 2.8391 4.961 2.072 9.4388
NCI-H835 GDSC1 2.8566 5.8974 1.6284 15.0682
NCI-H2803 GDSC1; GDSC2 2.8691 5.1864 1.9898 9.8489
SK-LU-1 GDSC1; GDSC2 2.8779 6.3944 1.4016 13.4727
NCI-H2810 GDSC1; GDSC2 2.8946 4.6088 2.2951 7.8608
NCI-H2818 GDSC1; GDSC2 2.8983 5.1347 2.0421 9.4242
NCI-H520 GDSC1; GDSC2 2.9197 5.5845 1.8402 10.6158
NCI-H1688 GDSC1 2.9324 4.9307 2.1736 10.5711
NCI-H650 GDSC1; GDSC2 2.9414 5.1385 2.0798 9.045
NCI-H2731 GDSC1; GDSC2 2.9426 7.1779 1.0694 15.2713
COR-L105 GDSC1; GDSC2 2.948 11.6635 -1.1644 26.1139
NCI-H1694 GDSC1; GDSC2 2.9613 5.1846 2.0753 9.007
NCI-H841 GDSC1; GDSC2 2.9759 5.3695 1.9972 9.4494
NCI-H1436 GDSC1 2.9844 4.1702 2.5918 7.1098
COR-L88 GDSC1 3.0238 5.023 2.2117 9.8965
NCI-H1650 GDSC1; GDSC2 3.052 4.2449 2.6199 5.2971
NCI-H2373 GDSC1; GDSC2 3.0521 7.8581 0.8252 16.351
NCI-H1092 GDSC1; GDSC2 3.1154 7.5608 1.028 14.9735
NCI-H1623 GDSC1; GDSC2 3.1292 6.3294 1.6547 11.1121
NCI-H2869 GDSC1; GDSC2 3.1361 7.6449 1.0037 15.0523
NCI-H522 GDSC1; GDSC2 3.1565 6.4295 1.6282 11.1936
NCI-H1355 GDSC1; GDSC2 3.1575 5.7864 1.9501 9.1724
NCI-H2029 GDSC1; GDSC2 3.1631 4.3781 2.6562 4.7006
Calu-6 GDSC1; GDSC2 3.1792 10.1626 -0.2181 21.4134
NCI-H2228 GDSC1; GDSC2 3.1794 7.2175 1.2542 13.4244
COR-L95 GDSC1 3.1912 7.4462 1.1499 17.197
DMS 53 GDSC1; GDSC2 3.2361 6.0672 1.8772 9.3939
NCI-H2087 GDSC1; GDSC2 3.2437 5.4666 2.1837 7.4369
HCC15 GDSC1; GDSC2 3.25 5.5606 2.1421 7.6814
BEN GDSC1 3.2752 5.2195 2.3339 7.9615
DMS 79 GDSC1; GDSC2 3.2848 6.2438 1.8299 9.5464
IST-SL2 GDSC1; GDSC2 3.3074 4.8476 2.547 4.9489
NCI-H1793 GDSC1; GDSC2 3.332 5.2454 2.3686 6.0066
NCI-H1836 GDSC1 3.3788 7.6365 1.2119 16.0604
NCI-H322M GDSC1; GDSC2 3.3841 8.1337 0.9676 14.5176
NCI-H187 GDSC1 3.3874 7.4446 1.3149 15.3021
NCI-H2081 GDSC1 3.408 7.387 1.3607 14.9002
NCI-H1304 GDSC1 3.4119 5.4365 2.3386 7.4336
NCI-H1781 GDSC1; GDSC2 3.4665 7.9609 1.1218 13.3698
NCI-H2066 GDSC1 3.4746 11.0099 -0.3956 24.9657
NCI-H720 GDSC1; GDSC2 3.4917 5.1985 2.5211 4.5975
ABC-1 GDSC1; GDSC2 3.5125 7.1245 1.577 10.4721
NCI-H2369 GDSC1; GDSC2 3.5198 5.2204 2.5321 4.4541
NCI-H513 GDSC1; GDSC2 3.5264 6.1525 2.0732 7.3289
Lu-65 GDSC1; GDSC2 3.5341 7.5178 1.3981 11.5111
NCI-H2141 GDSC1; GDSC2 3.5544 6.0011 2.1708 6.6385
NCI-H2405 GDSC1; GDSC2 3.5627 6.4871 1.9352 8.0982
NCI-H345 GDSC1; GDSC2 3.5748 5.4294 2.4708 4.6968
NCI-H2722 GDSC1; GDSC2 3.5882 6.7707 1.8141 8.7877
NCI-H2591 GDSC1; GDSC2 3.6511 9.9363 0.2849 17.5185
NCI-H441 GDSC1; GDSC2 3.6973 12.3341 -0.8753 22.7594
SW1573 GDSC1; GDSC2 3.7266 9.1146 0.7556 14.7541
IA-LM GDSC1; GDSC2 3.7338 13.0388 -1.1977 23.9243
Lu-165 GDSC1; GDSC2 3.7719 5.2858 2.685 2.8968
NCI-H2227 GDSC1; GDSC2 3.8121 9.0848 0.8381 14.0509
HOP-92 GDSC1; GDSC2 4.0332 6.6696 2.1974 5.2971
NCI-H2595 GDSC1; GDSC2 4.1186 9.9824 0.6301 14.3921
NCI-H1693 GDSC2 4.1645 9.848 0.7317 13.7125
NCI-H727 GDSC1; GDSC2 4.195 8.5187 1.4103 9.7093
NCI-H2135 GDSC1; GDSC2 4.228 7.2441 2.0549 5.7341
NCI-H250 GDSC2 4.3712 6.4746 2.5105 2.7695
NCI-H196 GDSC1; GDSC2 4.4516 7.9652 1.8609 6.4201
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 2.2725 4.6737 1.6512 14.0825
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-510 GDSC1 -1.3492 2.8105 -1.6458 56.5532
T.T GDSC1 -0.4224 1.9894 -0.4925 46.9679
OE33 GDSC1; GDSC2 -0.0088 2.0299 -0.0587 33.6709
TE-11 GDSC1 0.1538 3.4025 -0.1579 40.9617
KYSE-270 GDSC1; GDSC2 0.5564 3.3912 0.2846 29.1388
TE-9 GDSC1; GDSC2 0.9006 3.7038 0.5661 26.0514
EC-GI-10 GDSC1; GDSC2 0.9346 3.5733 0.6439 25.482
TE-4 GDSC1; GDSC2 1.0464 4.3909 0.4824 25.8284
KYSE-450 GDSC1; GDSC2 1.121 4.3102 0.5927 24.908
OE21 GDSC1; GDSC2 1.2267 5.3661 0.2745 26.1129
KYSE-140 GDSC1; GDSC2 1.2624 4.1115 0.8182 23.0574
KYSE-180 GDSC1; GDSC2 1.3063 3.3508 1.1143 21.2381
TE-10 GDSC1 1.3969 3.6346 1.1281 25.8203
TE-6 GDSC1; GDSC2 1.6625 3.7071 1.3928 18.1022
TE-8 GDSC1; GDSC2 1.9793 4.2521 1.5286 15.9767
TE-15 GDSC1; GDSC2 2.1979 5.2521 1.3123 16.3951
KYSE-150 GDSC1 2.4126 4.4457 1.8956 15.0383
OE19 GDSC1; GDSC2 2.4763 7.1848 0.6473 19.2619
COLO 680N GDSC1; GDSC2 2.4913 6.173 1.1562 16.2626
TE-5 GDSC1; GDSC2 2.8433 5.1438 1.9867 9.9553
KYSE-70 GDSC1; GDSC2 3.1216 5.6403 1.9918 9.0205
TE-1 GDSC1; GDSC2 3.1715 6.0282 1.8415 9.8131
KYSE-520 GDSC1; GDSC2 3.2176 6.3716 1.7093 10.503
KYSE-410 GDSC1; GDSC2 3.584 5.961 2.2139 6.2887
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 -1.1089 0.6205 -1.1145 55.3156
JHOS-4 GDSC1 -0.0165 5.0049 -0.8877 44.1986
JHOS-2 GDSC1 0.1865 4.226 -0.3833 41.454
DOV13 GDSC1; GDSC2 0.41 3.7392 0.021 31.1543
TOV-21G GDSC1; GDSC2 0.4811 3.2457 0.2421 29.72
A2780 GDSC1; GDSC2 0.8282 3.297 0.6072 26.1739
RMG-I GDSC1 0.9188 3.9536 0.5032 32.5338
OVTOKO GDSC1; GDSC2 0.9409 3.8442 0.5641 25.8761
OVCAR-5 GDSC1; GDSC2 1.3206 6.4969 -0.1354 27.7089
TOV-112D GDSC1; GDSC2 1.3257 3.578 1.0684 21.3997
TYK-nu GDSC1; GDSC2 1.4456 6.1652 0.1418 25.8555
FU-OV-1 GDSC1 1.7235 9.2275 -1.0498 34.6452
OVCAR-8 GDSC1; GDSC2 2.0431 4.6431 1.4301 16.2952
OVISE GDSC1; GDSC2 2.0605 5.3859 1.114 18.0902
OVK18 GDSC1; GDSC2 2.1137 3.8609 1.825 13.7042
Caov-4 GDSC1 2.3395 7.061 0.5816 24.4481
OAW42 GDSC1; GDSC2 2.636 5.288 1.7217 12.3143
ES-2 GDSC1; GDSC2 2.823 5.5836 1.7524 11.4831
OVCAR-3 GDSC1; GDSC2 2.907 7.1114 1.0712 15.374
IGROV-1 GDSC1; GDSC2 3.0089 6.1861 1.6213 11.6956
EFO-27 GDSC1; GDSC2 3.0286 7.3911 1.038 15.1845
SK-OV-3 GDSC1; GDSC2 3.3898 10.7669 -0.3442 21.3592
OV-90 GDSC1; GDSC2 3.4054 5.1963 2.4534 5.261
OVCAR-4 GDSC1; GDSC2 3.4659 5.8266 2.1875 6.7744
OAW28 GDSC1; GDSC2 3.4916 5.0083 2.6156 4.0024
EFO-21 GDSC1; GDSC2 3.6007 8.6244 0.8993 14.289
OV56 GDSC1; GDSC2 3.6087 5.9842 2.2216 6.1756
OVKATE GDSC1 3.9789 6.7957 2.0975 7.503
Kuramochi GDSC1; GDSC2 4.0787 10.0532 0.5643 14.8559
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1; GDSC2 -0.8384 6.8797 -2.5153 44.9799
MZ-PC-1 GDSC1 -0.3092 3.5165 -0.6956 46.236
Panc 03.27 GDSC1 -0.0429 3.1349 -0.3009 43.0259
SW1990 GDSC1 0.2265 8.3384 -2.0741 44.4321
Panc 04.03 GDSC1 0.2402 1.6771 0.2285 38.5908
PaTu 8988t GDSC1; GDSC2 0.6769 5.7902 -0.4769 32.0586
KP-4 GDSC1; GDSC2 0.777 7.1807 -0.9925 33.5372
BxPC-3 GDSC1; GDSC2 0.8663 3.1567 0.6853 25.5824
PL4 GDSC1; GDSC2 0.9775 3.0253 0.8378 24.2509
PSN1 GDSC1; GDSC2 1.2761 3.9226 0.9005 22.5444
YAPC GDSC1; GDSC2 1.5103 4.6013 0.8922 21.5761
KP-3 GDSC1; GDSC2 1.6554 5.1333 0.8175 21.3945
Capan-1 GDSC1; GDSC2 1.6899 5.3791 0.744 21.6661
Panc 08.13 GDSC1; GDSC2 1.853 6.7759 0.2576 23.6405
HuP-T4 GDSC1; GDSC2 1.8538 4.981 1.0878 19.0508
CFPAC-1 GDSC1; GDSC2 1.8926 5.7541 0.7768 20.6796
DAN-G GDSC1; GDSC2 2.1581 3.7762 1.9041 13.0631
Hs 766T GDSC1 2.8115 5.8408 1.6154 15.3539
KP-2 GDSC1; GDSC2 2.9466 9.4413 -0.0559 21.3686
Panc 02.03 GDSC1; GDSC2 2.9564 6.5087 1.4145 13.1403
KP-1N GDSC1; GDSC2 3.0061 6.9839 1.2215 14.1588
HPAC GDSC1; GDSC2 3.0801 6.6995 1.4276 12.6713
HPAF-II GDSC1; GDSC2 3.0889 5.4286 2.0686 8.6385
SU.86.86 GDSC1; GDSC2 3.1213 7.1865 1.22 13.8087
PaTu 8902 GDSC1; GDSC2 3.2002 7.1342 1.3134 13.002
SUIT-2 GDSC1; GDSC2 3.2495 5.4171 2.2134 7.2319
HuP-T3 GDSC1; GDSC2 3.7177 6.7783 1.9115 7.8353
Panc 10.05 GDSC1; GDSC2 3.9813 10.4974 0.2678 16.6874
QGP-1 GDSC1; GDSC2 4.1739 11.2882 0.0247 17.3967
Capan-2 GDSC2 4.925 11.3224 0.5662 12.7576
AsPC-1 GDSC2 4.9798 8.3666 2.0108 4.5315
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1 -0.1975 3.8807 -0.6848 45.2503
MSTO-211H GDSC1; GDSC2 1.2257 3.1827 1.0707 21.8462
MPP 89 GDSC1; GDSC2 2.6153 6.0632 1.3256 14.8131
IST-Mes1 GDSC1; GDSC2 3.2155 5.0541 2.3656 6.3715
NCI-H28 GDSC1; GDSC2 3.4019 7.1537 1.4723 11.4328
NCI-H2052 GDSC2 5.9105 8.2033 2.5559 0.8416
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 1.0296 5.103 0.1806 27.4529
PC-3 GDSC1; GDSC2 1.7246 6.049 0.4735 23.0089
DU145 GDSC1; GDSC2 1.8132 5.7496 0.6999 21.4209
VCaP GDSC1; GDSC2 2.5939 4.2465 2.1688 9.7362
22Rv1 GDSC1; GDSC2 3.2714 6.4658 1.7077 10.3521
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 1.245 4.7042 0.5707 24.4803
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-MEL1 GDSC1 0.09 3.0385 -0.132 41.3707
MZ-MEL-2 GDSC1 0.2081 3.6917 -0.184 40.6355
RPMI-7951 GDSC1; GDSC2 0.2444 2.5483 0.1385 31.4134
SK-MEL-3 GDSC1 0.4462 13.4608 -4.3063 45.4396
LOX-IMVI GDSC1; GDSC2 0.6396 3.2557 0.4125 28.085
UACC-62 GDSC1; GDSC2 0.646 2.7123 0.5426 27.3818
A-375 GDSC1; GDSC2 0.6551 2.5852 0.5746 27.1728
A101D GDSC1; GDSC2 0.7033 2.1722 0.6772 26.41
RVH-421 GDSC1 0.8473 3.1984 0.654 32.1192
A-431 GDSC1 0.8713 3.6159 0.5618 32.5045
DJM-1 GDSC1 0.9365 3.1091 0.7735 30.8364
Mel Ho GDSC1 0.9372 2.5785 0.8782 30.1799
Hs 938.T GDSC1 0.9921 3.2398 0.8013 30.321
COLO 783 GDSC1 1.0414 2.9775 0.918 29.2881
WM793 GDSC1; GDSC2 1.0584 2.4839 1.02 22.9101
IGR-1 GDSC1; GDSC2 1.0586 2.7735 0.9771 23.1318
SK-MEL-2 GDSC1; GDSC2 1.1238 3.2249 0.9489 22.9732
Hs 940.T GDSC1 1.1262 5.9329 -0.0768 34.1251
G-361 GDSC1; GDSC2 1.1522 3.8002 0.8081 23.6037
CP50-MEL-B GDSC1 1.1608 2.9613 1.0513 27.7131
MeWo GDSC1 1.2044 3.3827 0.9941 27.8203
LB2518-MEL GDSC1 1.2274 3.3059 1.0404 27.385
IPC-298 GDSC1 1.2832 3.5137 1.0418 27.0469
SH-4 GDSC1; GDSC2 1.3177 6.247 -0.024 27.1981
LB373-MEL-D GDSC1 1.335 3.0189 1.2281 25.5242
WM115 GDSC1; GDSC2 1.3733 4.3586 0.8438 22.4312
HMV-II GDSC1; GDSC2 1.3838 4.1864 0.9208 21.9585
WM35 GDSC1 1.4211 2.9538 1.3352 24.3124
CHL-1 GDSC1; GDSC2 1.4339 5.6963 0.342 24.8857
COLO 800 GDSC1 1.4642 3.8631 1.1246 25.4595
SK-MEL-31 GDSC1 1.5149 4.9236 0.7626 27.4991
HT-144 GDSC1; GDSC2 1.5312 4.3885 0.9999 20.8824
MMAc-SF GDSC1 1.5957 4.247 1.124 24.7298
A-388 GDSC1 1.6358 4.0734 1.2332 23.7735
SK-MEL-28 GDSC1 1.6541 5.0428 0.8556 26.1626
COLO 679 GDSC1; GDSC2 1.6928 3.6867 1.4325 17.7469
SK-MEL-30 GDSC1 1.7016 3.4346 1.5216 21.4406
451Lu GDSC1 1.7905 3.9832 1.4328 21.5584
WM1552C GDSC1; GDSC2 1.8956 4.0261 1.5291 16.3234
MZ-MEL-7 GDSC1 1.9028 3.87 1.5953 19.8179
A2058 GDSC2 2.0192 3.5249 1.84 14.0305
SK-MEL-5 GDSC1; GDSC2 2.0545 5.3264 1.1353 17.9884
COLO 792 GDSC1; GDSC2 2.1369 3.6173 1.9374 12.9668
G-mel GDSC1; GDSC2 2.1417 4.0666 1.7749 13.8747
IGR-37 GDSC1; GDSC2 2.2119 3.0626 2.1701 11.3546
WM278 GDSC1; GDSC2 2.2125 4.96 1.4612 15.4503
GAK GDSC1; GDSC2 2.2212 4.3919 1.7227 13.8578
M14 GDSC1; GDSC2 2.3555 3.8005 2.1066 11.0649
SK-MEL-24 GDSC1; GDSC2 2.5166 9.7825 -0.6018 25.2713
CP66-MEL GDSC1; GDSC2 2.5351 4.0077 2.2125 9.7078
SK-MEL-1 GDSC1 2.7834 4.6967 2.1467 11.4205
UACC-257 GDSC1; GDSC2 2.9315 6.5266 1.3836 13.4096
Mel JuSo GDSC1; GDSC2 3.0492 9.293 0.1062 20.2413
COLO 829 GDSC1; GDSC2 3.2917 4.9042 2.5055 5.2576
WT2-iPS GDSC1; GDSC2 3.3775 6.2085 1.9247 8.6808
VMRC-MELG GDSC1 3.4076 5.1097 2.4984 6.1913
EquiPSC Line K2 GDSC1 0.9215 3.2973 0.709 31.323
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 2.0062 6.4893 0.542 21.5476
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 -0.6984 2.1517 -0.8103 50.2315
G-402 GDSC1; GDSC2 -0.283 4.3265 -0.9261 38.657
STS-0421 GDSC1 0.4339 2.1364 0.3975 36.3176
SW982 GDSC1; GDSC2 0.5033 2.1282 0.4713 28.4473
KYM-1 GDSC1; GDSC2 0.6072 1.742 0.6019 27.2693
MES-SA GDSC1; GDSC2 0.8169 2.8706 0.6968 25.757
Rh41 GDSC1; GDSC2 0.8312 3.1683 0.6441 25.965
VA-ES-BJ GDSC1; GDSC2 0.9579 2.6293 0.8928 24.0567
SK-UT-1 GDSC1; GDSC2 1.1958 4.9332 0.4253 25.467
RD GDSC1; GDSC2 1.2805 5.6291 0.2153 26.1824
A-204 GDSC1; GDSC2 1.4771 6.2354 0.1411 25.7293
MFH-ino GDSC1 1.5064 4.9502 0.7426 27.6689
HT-1080 GDSC1; GDSC2 1.6591 4.6636 1.0225 20.2174
G-401 GDSC1; GDSC2 1.8704 3.8381 1.572 16.1866
EW-8 GDSC1; GDSC2 1.9525 4.2655 1.4949 16.2828
GCT GDSC1; GDSC2 2.5089 6.7624 0.8846 17.7991
Rh18 GDSC1 2.5996 6.0366 1.324 18.3982
SW872 GDSC1; GDSC2 2.6111 7.2375 0.7443 18.2526
SK-LMS-1 GDSC1; GDSC2 2.8316 3.9298 2.5519 6.5178
Rh30 GDSC1; GDSC2 2.8514 3.9856 2.5468 6.4724
RKN GDSC1; GDSC2 3.3757 5.0734 2.4906 5.1096
SW684 GDSC1; GDSC2 3.661 10.9698 -0.2232 20.0052
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 GDSC1 -0.316 5.154 -1.2646 46.9887
HSC-39 GDSC1 0.2384 2.4547 0.1477 39.028
HGC-27 GDSC2 0.591 4.5906 -0.0805 30.743
ECC10 GDSC1; GDSC2 0.6232 2.1931 0.5912 27.2437
SNU-16 GDSC1 0.7629 3.2777 0.5411 33.3185
AGS GDSC1; GDSC2 0.9 2.7029 0.8184 24.7228
SNU-5 GDSC1; GDSC2 0.9291 2.2538 0.9067 24.1257
OCUM-1 GDSC1; GDSC2 0.9371 2.6621 0.8653 24.3
TMK-1 GDSC1 1.3645 3.3676 1.1731 25.7113
SCH GDSC1 1.4179 4.1511 0.9706 26.7311
TGBC11TKB GDSC1; GDSC2 1.4901 2.9902 1.4027 18.835
MKN45 GDSC1; GDSC2 1.4947 3.5468 1.2621 19.5743
MKN1 GDSC1; GDSC2 1.5291 5.3625 0.5873 23.1854
23132/87 GDSC1; GDSC2 1.5557 3.2639 1.4099 18.4899
MKN28 GDSC1; GDSC2 1.7231 4.3337 1.225 18.7934
IM95 GDSC1; GDSC2 1.7789 4.377 1.2665 18.322
RERF-GC-1B GDSC1; GDSC2 1.973 4.9932 1.2041 17.9011
RF-48 GDSC1; GDSC2 2.0085 3.8789 1.7055 14.8354
SK-GT-2 GDSC1; GDSC2 2.1055 5.3418 1.1791 17.5353
GCIY GDSC2 2.3948 6.6604 0.8286 18.5218
NUGC-3 GDSC1; GDSC2 2.4977 4.4103 1.9978 11.1346
SNU-1 GDSC1; GDSC2 2.5336 4.0296 2.2017 9.7771
MKN7 GDSC1 2.8455 5.8851 1.6245 15.1435
Hs 746.T GDSC1; GDSC2 3.0517 6.6816 1.412 12.8552
NUGC-4 GDSC1; GDSC2 3.1497 4.9679 2.3513 6.6649
NCI-N87 GDSC1; GDSC2 3.1573 8.7175 0.4857 17.919
ECC12 GDSC2 3.2547 4.2808 2.7854 3.5977
KATO III GDSC1; GDSC2 3.2823 6.4251 1.7372 10.1357
SNG-M GDSC1; GDSC2 0.54 4.8864 -0.2489 31.7487
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1 -1.6501 2.8281 -1.9777 59.0821
K5 GDSC1; GDSC2 0.1159 1.7831 0.094 32.2828
IHH-4 GDSC1; GDSC2 0.853 3.1113 0.682 25.6627
HTC-C3 GDSC1; GDSC2 1.0614 4.1194 0.599 25.1418
TT GDSC1 1.4089 10.5612 -1.9938 38.5472
B-CPAP GDSC1; GDSC2 1.59 5.518 0.5803 22.9736
8305C GDSC1; GDSC2 2.6485 5.4855 1.638 12.7861
BHT-101 GDSC1; GDSC2 2.7414 3.9819 2.4368 7.558
ASH-3 GDSC1; GDSC2 2.8157 4.9977 2.0321 9.7674
CAL-62 GDSC1; GDSC2 2.8809 5.9605 1.6192 12.1201
8505C GDSC1; GDSC2 2.9663 4.7729 2.2823 7.695
FTC-133 GDSC1; GDSC2 3.0852 9.7317 -0.0823 21.058
TT2609-C02 GDSC1; GDSC2 3.4751 6.8796 1.6691 10.0053
WRO GDSC1; GDSC2 3.6189 6.1405 2.1518 6.5873
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FaDu GDSC1; GDSC2 -0.7279 1.6073 -0.7739 40.8329
PCI-38 GDSC1 -0.7041 2.2946 -0.84 50.2926
Detroit 562 GDSC1; GDSC2 -0.5782 2.2629 -0.699 39.64
KOSC-2 GDSC1 -0.3265 3.8649 -0.8202 46.5706
KON GDSC1 -0.1439 1.4695 -0.1569 43.3855
HO-1-u-1 GDSC1 -0.1205 2.1163 -0.1875 43.312
JHU-011 GDSC1 -0.1102 1.4012 -0.1195 42.9492
CAL-27 GDSC1; GDSC2 0.0492 4.2647 -0.5453 35.4758
JHU-029 GDSC1 0.0733 3.4576 -0.2613 41.9514
BICR 22 GDSC1; GDSC2 0.275 3.9916 -0.2075 32.8876
HSC-2 GDSC1; GDSC2 0.2888 3.6 -0.0681 32.1831
HSC-3 GDSC1; GDSC2 0.4809 3.6688 0.1202 30.3249
PE/CA-PJ15 GDSC1 0.4928 4.728 -0.2379 38.7673
BB30-HNC GDSC1 0.5479 3.0598 0.3619 35.7385
PCI-15A GDSC1 0.6058 4.0593 0.128 36.4942
HO-1-N-1 GDSC1; GDSC2 0.732 4.0393 0.2714 28.3652
SAS GDSC1; GDSC2 0.9398 4.5927 0.2911 27.3019
OSC-19 GDSC1 1.099 3.2888 0.9049 29.021
SAT [Human HNSCC] GDSC1; GDSC2 1.1185 4.0671 0.6792 24.4541
BHY GDSC1 1.2357 4.8191 0.5141 30.5468
PCI-04B GDSC1; GDSC2 1.4399 3.7519 1.1364 20.5134
NCI-H3118 GDSC1; GDSC2 1.4941 4.7917 0.7965 22.1795
PCI-06A GDSC1 1.5131 4.4909 0.9398 26.3948
BB49-HNC GDSC1; GDSC2 1.518 4.8007 0.8177 21.9608
PCI-30 GDSC1 1.5311 6.6441 0.0053 31.5066
SCC-9 GDSC1; GDSC2 1.5535 3.4997 1.3406 18.8777
JHU-022 GDSC1; GDSC2 1.7013 4.9597 0.9403 20.5127
SKN-3 GDSC1; GDSC2 1.7178 5.1797 0.8611 20.8954
DOK GDSC1; GDSC2 1.7261 3.9051 1.3923 17.8271
CAL-33 GDSC1; GDSC2 2.0638 4.3096 1.5936 15.2516
SCC-25 GDSC1 2.1429 3.6012 1.9494 16.0344
UPCI-SCC-090 GDSC1; GDSC2 2.245 4.2222 1.8196 13.1907
LB771-HNC GDSC1; GDSC2 2.2708 3.8801 1.9855 12.1182
SCC-15 GDSC1; GDSC2 2.4413 4.5764 1.8658 12.1457
SCC-4 GDSC1; GDSC2 2.5306 6.8986 0.8378 17.9941
Ca9-22 GDSC1; GDSC2 3.0201 6.614 1.418 12.9174
OSC-20 GDSC1; GDSC2 3.1012 5.7068 1.9409 9.4044
BICR 78 GDSC1; GDSC2 3.2224 5.0371 2.3801 6.2592
HSC-4 GDSC1; GDSC2 3.2989 8.2195 0.8539 15.4294
BICR 10 GDSC1; GDSC2 3.3695 5.4812 2.2817 6.4492
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T24 GDSC1 -2.8559 1.9211 -3.0958 68.9956
UM-UC-3 GDSC1 -0.9493 4.0853 -1.5682 52.3814
KU-19-19 GDSC1; GDSC2 0.2744 3.9369 -0.1902 32.8137
BFTC-905 GDSC1; GDSC2 1.4506 5.277 0.5442 23.7456
SW780 GDSC1; GDSC2 1.5217 4.7028 0.8624 21.6953
RT-112 GDSC1; GDSC2 1.825 4.9356 1.0782 19.2216
639V GDSC1; GDSC2 1.8492 4.3012 1.3714 17.4251
CAL-29 GDSC1; GDSC2 2.0374 6.4544 0.5888 21.1736
RT-4 GDSC1; GDSC2 2.2281 4.9486 1.482 15.2662
SW1710 GDSC1; GDSC2 2.6185 5.3332 1.6833 12.6118
647V GDSC1; GDSC2 2.9509 4.108 2.5888 5.8462
5637 GDSC1; GDSC2 3.158 7.1249 1.2822 13.3196
TCCSUP GDSC1; GDSC2 3.2394 4.3277 2.7488 3.8761
HT-1197 GDSC1; GDSC2 3.275 4.8109 2.5379 5.1021
HT-1376 GDSC1; GDSC2 3.7575 8.4436 1.1144 12.5985
J82 GDSC1; GDSC2 3.79 7.5748 1.5719 9.7515
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JAR GDSC1 -3.1046 4.3285 -3.9902 65.6176
ACC-OV7 GDSC1 -0.7319 7.0159 -2.4623 50.3454
SW954 GDSC1 -0.5976 2.7575 -0.8157 49.1309
NT2-D1 GDSC1 -0.3811 3.7383 -0.8402 47.076
OVCA433 GDSC1 -0.1421 3.0464 -0.3869 44.1152
PA-1 GDSC2 -0.1383 2.8772 -0.3429 35.6686
KGN GDSC1 0.0465 3.3086 -0.249 42.1274
MS751 GDSC1; GDSC2 0.1569 3.1189 -0.0789 32.9096
OVCA420 GDSC1 0.3105 6.5212 -1.1713 42.5203
HEY GDSC1; GDSC2 0.6774 2.4752 0.6153 26.8546
DoTc2 4510 GDSC1; GDSC2 0.7317 2.5428 0.6635 26.3413
SiSo GDSC1; GDSC2 0.7689 5.0872 -0.0868 29.9279
HeLa GDSC1; GDSC2 1.024 3.9315 0.6247 25.1735
JEG-3 GDSC1 1.0301 3.938 0.6291 31.1235
NEC8 GDSC1; GDSC2 1.0371 2.573 0.9858 23.1901
OVMIU GDSC1; GDSC2 1.1104 5.9019 -0.0791 28.3489
CAL-39 GDSC1; GDSC2 1.1771 3.7504 0.8516 23.2552
SW962 GDSC1 1.3429 4.4673 0.769 28.4286
C-33 A GDSC1; GDSC2 1.3432 5.3015 0.4228 24.8453
BPH-1 GDSC1; GDSC2 1.4429 8.4945 -0.959 30.6187
HT-3 GDSC1; GDSC2 1.53 5.9028 0.3461 24.4673
OMC-1 [Human cervical carcinoma] GDSC1 1.6545 4.0855 1.2487 23.565
C-4-I GDSC1; GDSC2 1.8282 8.8581 -0.7719 28.4196
Ca Ski GDSC1; GDSC2 1.8346 5.8497 0.675 21.4752
TC-YIK GDSC1; GDSC2 1.8611 4.2594 1.4008 17.2065
LB831-BLC GDSC1; GDSC2 1.8806 4.3582 1.3813 17.2381
JHOS-3 GDSC1 2.1781 9.724 -0.8761 32.0303
ME-180 GDSC1; GDSC2 2.3216 5.342 1.3923 15.4545
OV17R GDSC1 2.3288 6.4215 0.8828 22.6282
DSH1 GDSC1; GDSC2 2.4402 3.3782 2.3437 9.3598
UWB1.289 GDSC1 2.7308 5.915 1.5049 16.516
SiHa GDSC1; GDSC2 2.9933 3.9125 2.7223 4.8742
PEO1 GDSC1; GDSC2 3.202 6.544 1.6099 11.17
PWR-1E GDSC1; GDSC2 3.2667 7.7583 1.0576 14.3375
SKG-IIIa GDSC1; GDSC2 3.2777 8.9419 0.475 17.6084
SKN GDSC1; GDSC2 3.2843 5.9961 1.9534 8.7705
HEC-1 GDSC1; GDSC2 3.4304 5.1551 2.4941 4.9346
SW756 GDSC1; GDSC2 3.4834 5.4027 2.4129 5.3028
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8473).
2 AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.Int J Radiat Oncol Biol Phys.2012 Nov 15;84(4):e507-14.