Details of the Drug

General Information of Drug (ID: DMBR8NF)

Drug Name
MLN2480
Synonyms
VWMJHAFYPMOMGF-ZCFIWIBFSA-N; 1096708-71-2; MLN 2480; BIIB-024; Tak-580; MLN-2480; BIIB024; UNII-ZN90E4027M; BIIB 024; 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-; ZN90E4027M; (r)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-n-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide; 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl]-; AMG 2112819
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Melanoma 2C30 Phase 1 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 506.3
Logarithm of the Partition Coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 11
Chemical Identifiers
Formula
C17H12Cl2F3N7O2S
IUPAC Name
2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide
Canonical SMILES
C[C@H](C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl
InChI
InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
InChIKey
VWMJHAFYPMOMGF-ZCFIWIBFSA-N
Cross-matching ID
PubChem CID
25161177
CAS Number
1096708-71-2
UNII
ZN90E4027M
DrugBank ID
DB15266
TTD ID
D07IEU
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B-Raf messenger RNA (BRAF mRNA) TT0EOB8 BRAF_HUMAN Inhibitor [3]
Raf messenger RNA (Raf mRNA) TTAN5W2 RAF1_HUMAN Inhibitor [4]
Serine/threonine-protein kinase Raf (RAF) TTQ9K3Y ARAF_HUMAN ; BRAF_HUMAN ; RAF1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Raf messenger RNA (Raf mRNA) DTT RAF1 2.12E-04 0.49 2.78
B-Raf messenger RNA (BRAF mRNA) DTT BRAF 1.56E-01 -0.23 -0.43
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 65 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.7354 7.4968 5.047 4.8295
JM1 CTRP2 5.5397 7.5798 4.8241 6.1943
EoL-1 CTRP2 -9.8881 -6.1285 -9.8884 94.7627
OCI-AML-3 CTRP2 1.11 3.0925 1.1025 32.8985
KO52 CTRP2 2.5572 8.3234 1.4419 27.1236
K-562 CTRP2 3.8423 7.3756 3.1812 17.0941
AML-193 CTRP2 3.9666 6.733 3.5575 15.3153
SUP-M2 CTRP2 4.2965 7.0207 3.8034 13.4492
HuT 78 CTRP2 4.4796 7.1126 3.9607 12.3387
OPM-2 CTRP2 4.5416 7.8379 3.7155 13.1365
M-07e CTRP2 4.5743 7.0429 4.0889 11.5841
SIG-M5 CTRP2 4.6798 7.7941 3.8756 12.1445
GA-10 CTRP2 4.796 7.2962 4.214 10.501
Kasumi-1 CTRP2 4.923 10.4382 2.8549 15.6742
EB1 CTRP2 4.954 9.1269 3.5212 12.9084
Granta-519 CTRP2 4.9775 9.3223 3.4491 13.1477
OCI-Ly10 CTRP2 5.0552 10.3627 3.0141 14.736
SUP-HD1 CTRP2 5.0862 7.0959 4.6 8.2158
A4/Fukuda CTRP2 5.1859 7.04 4.7268 7.4544
DND-41 CTRP2 5.2077 8.924 3.8592 10.9362
NU-DHL-1 CTRP2 5.2127 7.0696 4.741 7.3285
Pfeiffer CTRP2 5.2229 9.329 3.6756 11.6585
Kasumi-2 CTRP2 5.2598 8.5314 4.0988 9.8292
KMS-20 CTRP2 5.2884 9.0433 3.8762 10.6833
MOLT-3 CTRP2 5.3327 8.5559 4.1554 9.4288
Hs 611.T CTRP2 5.34 7.6443 4.6018 7.576
Mino CTRP2 5.4602 6.8516 5.0897 5.3042
697 CTRP2 5.4865 7.5262 4.7993 6.4204
ST486 CTRP2 5.5336 6.3819 5.3687 4.0105
TF-1 CTRP2 5.5713 6.8262 5.2127 4.5308
CA46 CTRP2 5.5769 7.5532 4.8721 5.9109
BL-70 CTRP2 5.6043 6.029 5.5682 3.058
SEM CTRP2 5.8281 7.1486 5.303 3.5605
DB CTRP2 5.8403 7.4172 5.1812 4.0424
MOLP-8 CTRP2 5.9126 8.39 4.0281 3.3065
U266B1 CTRP2 5.9201 7.0167 5.4511 2.7444
JeKo-1 CTRP2 6.0106 7.8737 5.1014 4.0292
Daudi CTRP2 6.02 7.8907 5.1008 4.0136
EJM CTRP2 6.0202 9.786 4.1534 7.9932
OCI-Ly19 CTRP2 6.086 9.0332 4.5845 6.0565
HD-MY-Z CTRP2 6.0941 7.7814 5.217 3.383
OCI-Ly3 CTRP2 6.1028 8.8917 4.6692 5.6687
A3/Kawakami CTRP2 6.1561 7.478 5.4184 2.4234
Ci-1 CTRP2 6.1985 7.4081 5.4863 2.0648
Namalwa CTRP2 6.2306 8.1243 5.1553 3.393
MOTN-1 CTRP2 6.2634 7.4514 5.514 1.8406
L-428 CTRP2 6.4015 8.8736 4.9152 4.1002
F-36P CTRP2 6.4112 7.8947 5.4043 2.0599
HL-60 CTRP2 6.4272 7.6596 5.5293 1.5284
JJN-3 CTRP2 6.447 7.9371 5.4089 1.987
Toledo CTRP2 6.5167 8.4829 5.1928 2.7645
Karpas-422 CTRP2 6.5361 8.9414 4.9824 3.5998
SET-2 CTRP2 6.5378 7.8175 5.5276 1.384
HH [Human lymphoma] CTRP2 6.6026 8.7265 5.1353 2.8692
HEL 92.1.7 CTRP2 6.6488 8.1411 5.4468 1.557
RL CTRP2 6.6701 8.478 5.3013 2.1023
SUP-B15 CTRP2 6.7294 9.7827 4.7108 4.4135
OCI-AML-5 CTRP2 6.7882 9.1992 5.0356 3.0015
LP-1 CTRP2 7.0508 8.7081 5.4282 1.1748
HuNS1 CTRP2 7.174 9.9067 4.9539 2.8071
MJ CTRP2 7.1858 9.2907 5.2449 1.693
BL-41 CTRP2 7.2304 10.7196 4.606 4.1031
CMK CTRP2 7.6166 9.6525 5.3209 1.0387
OCI-M1 CTRP2 7.6524 8.6971 5.7068 0.1058
RPMI-6666 CTRP2 7.91 9.4574 5.5318 0.3206
⏷ Show the Full List of 65 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.258 7.629 5.4223 2.2305
TE-5 CTRP2 5.3191 8.7061 4.0694 9.8154
OE21 CTRP2 6.0003 7.7733 5.1429 3.875
EC-GI-10 CTRP2 6.4477 9.6015 4.5897 5.379
TE-11 CTRP2 6.5213 7.9367 5.4601 1.6737
TE-14 CTRP2 6.5925 8.3536 5.3085 2.1816
KYSE-30 CTRP2 6.9519 8.9737 5.2493 1.943
KYSE-510 CTRP2 7.0831 9.1808 5.234 1.8467
KYSE-520 CTRP2 7.6877 12.1189 4.2432 4.9211
KYSE-450 CTRP2 7.908 9.312 5.5844 0.2244
KYSE-150 CTRP2 7.9385 10.1814 5.26 0.9881
OE19 CTRP2 8.1341 9.3913 5.6404 0.0976
OE33 CTRP2 8.8937 19.7713 1.3862 13.8345
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.489 12.3006 4.642 2.5259
Hs 766T CTRP2 4.002 8.3183 2.9514 17.5513
PSN1 CTRP2 4.5313 7.2731 3.4781 8.8453
PaTu 8988s CTRP2 4.8058 12.4858 1.741 20.182
HuP-T3 CTRP2 5.2764 7.9655 4.3872 8.6049
MIA PaCa-2 CTRP2 5.5827 7.1565 5.0686 5.0891
AsPC-1 CTRP2 6.3904 8.7636 4.9613 3.9272
PaTu 8988t CTRP2 6.4601 8.3349 4.3754 1.1455
Panc 08.13 CTRP2 6.5141 10.9631 3.9647 7.8699
SW1990 CTRP2 6.523 8.6787 5.1017 3.1289
DAN-G CTRP2 6.542 8.393 5.2545 2.4741
Capan-1 CTRP2 6.5637 11.3152 3.8283 8.3488
Panc 04.03 CTRP2 6.5645 7.9703 5.4728 1.5646
Panc 03.27 CTRP2 6.5928 8.5341 4.3585 1.0886
Panc 10.05 CTRP2 6.7212 9.178 4.9995 3.2452
KP-2 CTRP2 6.8329 9.5541 4.8953 3.5037
Capan-2 CTRP2 7.1128 10.2475 4.7527 3.6804
PK-45H CTRP2 7.4325 16.1608 2.0913 13.6989
Panc 02.03 CTRP2 8.8914 17.3274 1.7361 8.8861
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.926 10.6986 0.7916 28.1382
Malme-3M CTRP2 1.1102 7.5298 0.1916 35.5627
WM88 CTRP2 2.3881 4.9319 2.2936 24.6796
WM983B CTRP2 3.1486 9.4509 1.5786 24.9511
COLO 800 CTRP2 3.4217 7.6369 2.6315 20.3539
COLO 829 CTRP2 3.6256 9.6596 1.9676 22.2726
HT-144 CTRP2 3.8532 8.7187 2.1398 16.9473
LOX-IMVI CTRP2 4.0281 8.1232 3.0635 17.0454
WM115 CTRP2 4.0719 10.2589 2.1305 20.5193
IGR-1 CTRP2 4.4067 11.7871 1.7154 21.2112
UACC-257 CTRP2 4.8898 10.8608 2.6172 16.6906
WM266-4 CTRP2 4.9096 9.9379 3.0865 14.7763
UACC-62 CTRP2 5.3487 11.0766 2.9273 14.4382
Hs 934.T CTRP2 5.3584 12.7297 2.1142 17.5834
A101D CTRP2 5.3614 9.6615 2.9944 9.2659
COLO 792 CTRP2 5.5174 8.5206 3.683 5.6356
K029AX CTRP2 5.7375 13.2689 2.1733 16.5627
Hs 294T CTRP2 5.84 11.8761 2.2668 11.6912
WT2-iPS CTRP2 5.8645 10.9831 2.7277 9.5138
IGR-37 CTRP2 5.8914 10.2847 3.7955 9.7445
MeWo CTRP2 6.0374 7.7481 5.1867 3.6188
SK-MEL-3 CTRP2 6.0825 13.1586 2.519 14.5455
A2058 CTRP2 6.0951 7.3357 4.6107 0.6293
RVH-421 CTRP2 6.4983 10.7845 4.0412 7.5793
Hs 688(A).T CTRP2 6.5626 8.5018 5.2162 2.5994
HMCB CTRP2 6.6177 7.6852 4.6982 0.1441
Hs 940.T CTRP2 6.6365 11.7115 3.6879 8.8018
Hs 895.T CTRP2 7.1708 11.2737 4.2986 5.4262
SK-MEL-2 CTRP2 7.2206 18.1384 0.2106 17.2967
CJM [Human melanoma] CTRP2 7.2378 8.8325 5.4744 0.854
Hs 839.T CTRP2 7.4279 11.973 4.1388 5.6956
SK-MEL-24 CTRP2 7.469 14.3989 2.9867 10.2361
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 6.1277 12.7663 2.0449 12.1176
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-BE(2) CTRP2 5.2907 8.0673 4.3522 8.7148
SK-N-AS CTRP2 5.4098 6.9848 4.9785 5.8773
CHP-212 CTRP2 5.4908 7.1915 4.9627 5.7416
SK-N-DZ CTRP2 5.8692 9.9214 3.958 9.1099
IMR-32 CTRP2 6.0501 12.1558 2.9934 12.7302
NH-6 CTRP2 6.3557 10.5888 4.0261 7.8971
SK-N-SH CTRP2 6.5536 11.2361 3.098 6.5597
KP-N-YN CTRP2 6.9 13.4284 3.0389 10.9805
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 6.9633 10.4352 4.5597 4.674
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 4.9468 9.6848 3.2445 14.0517
SK-ES-1 CTRP2 6.1764 7.503 5.4219 2.3726
G-292 clone A141B1 CTRP2 6.254 7.5354 5.4655 2.0575
Hs 888.T CTRP2 6.5502 9.5301 4.703 4.7343
SK-N-MC CTRP2 6.568 8.947 5.003 3.4646
Hs 822.T CTRP2 6.6485 8.0713 5.4793 1.4311
HOS CTRP2 6.7467 8.5911 4.409 0.8
SaOS-2 CTRP2 7.0582 9.2058 5.2074 1.9756
TC71 CTRP2 7.7173 8.7925 5.6973 0.1051
MG-63 CTRP2 8.3165 14.9337 3.3209 7.6688
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 0.9603 4.1432 0.8761 34.1455
UACC-812 CTRP2 4.9981 15.9911 0.1743 24.7859
MDA-MB-157 CTRP2 5.2856 12.2775 2.2749 17.1334
AU565 CTRP2 5.327 9.5856 3.6454 11.5518
Hs 578T CTRP2 5.6466 15.4294 1.0164 20.8214
HCC2218 CTRP2 5.6792 8.8027 4.3502 7.8586
MDA-MB-453 CTRP2 5.8217 7.401 5.1726 4.1184
SK-BR-3 CTRP2 5.955 7.7963 5.0929 4.1756
HCC38 CTRP2 5.961 7.5459 5.223 3.617
CAL-85-1 CTRP2 6.0074 8.5629 4.0084 3.2496
HCC1500 CTRP2 6.3628 8.063 5.2866 2.6211
MDA-MB-468 CTRP2 6.5838 8.0642 5.4409 1.665
MDA-MB-415 CTRP2 6.7268 13.3789 2.9292 11.7225
BT-474 CTRP2 6.7301 8.2486 5.4479 1.4519
T-47D CTRP2 6.8593 9.3507 5.0112 2.9989
BT-20 CTRP2 6.8605 8.3837 5.4645 1.2406
ZR-75-30 CTRP2 7.1016 9.0135 5.3209 1.5062
HCC1428 CTRP2 7.1227 8.8305 5.4142 1.1545
HCC1419 CTRP2 7.3861 9.4005 5.3086 1.2714
EFM-192A CTRP2 7.4672 9.006 5.5145 0.5748
BT-549 CTRP2 8.5233 10.4251 5.4201 0.3198
HCC202 CTRP2 8.6348 11.0733 5.2226 0.6838
Hs 578Bst CTRP2 11.1432 34.8457 -4.3596 24.4608
MDA-MB-361 CTRP2 11.9647 29.8177 -1.3438 17.3466
BT 286 CTRP2 0.8867 4.6675 0.723 34.8823
BT 239 CTRP2 1.9917 6.6503 1.4424 28.8673
BT 145 CTRP2 2.2005 7.3873 1.4189 28.2885
BT 440 CTRP2 2.2076 8.4191 1.0336 29.5168
BT 428 CTRP2 2.8506 8.9712 1.4803 26.1331
BT 482 CTRP2 3.0127 7.2441 2.3451 22.5879
BT147 CTRP2 3.0926 9.701 1.4103 25.6823
BT164 CTRP2 3.4983 9.0071 2.1322 22.0099
BT 271 CTRP2 3.5564 8.3581 2.4746 20.5733
BT 172 CTRP2 3.7031 8.195 2.6964 19.3327
BT 179 CTRP2 3.8423 7.5023 3.1304 17.2884
BT 504 CTRP2 3.9429 8.2108 2.9377 17.7606
BT 416 CTRP2 4.217 6.8958 3.7668 13.8116
BT 231 CTRP2 4.2364 9.0573 2.8545 17.3261
BT 330 CTRP2 4.4089 9.2428 2.9385 16.5639
BT 139 CTRP2 4.7271 8.3 3.6922 12.7604
BT 159 CTRP2 4.9751 7.0882 4.4889 8.9458
BT 444 CTRP2 5.0052 9.5419 3.3688 13.4114
BT 228 CTRP2 5.0509 7.493 4.3865 9.1581
BT 131 CTRP2 5.2445 10.2618 3.2369 13.4114
BT 232 CTRP2 5.2822 9.2871 3.751 11.2147
BT 248 CTRP2 5.5313 7.9628 4.63 7.016
BT 359 CTRP2 5.5952 10.6701 3.3473 12.2065
BT 112 CTRP2 5.6093 11.5608 2.9157 13.9327
BT 498 CTRP2 5.71 7.7176 4.915 5.4348
BT 245 CTRP2 5.7293 9.5222 4.0364 9.0667
BT 340 CTRP2 5.7784 10.8235 3.4297 11.49
BT 422 CTRP2 5.9275 9.5762 4.1802 8.0631
BT 216 CTRP2 5.9445 14.0649 1.9506 16.9694
BT 333 CTRP2 6.2595 10.5927 3.9469 8.4042
BT 224 CTRP2 6.4391 10.962 3.9063 8.2459
BT 320 CTRP2 7.0746 12.606 3.5776 8.5134
BT 328 CTRP2 7.2439 12.2142 3.893 6.9622
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KG-1-C CTRP2 4.3715 13.1953 0.9943 23.7443
D283 Med CTRP2 6.0679 7.3484 5.4119 2.6136
U-118MG CTRP2 6.2068 8.2009 5.0983 3.674
SW1783 CTRP2 6.226 8.0749 5.1762 3.3136
GMS-10 CTRP2 6.3818 8.6896 4.1788 1.9978
GOS-3 CTRP2 6.4159 8.7724 4.1612 2.0302
KNS-42 CTRP2 6.5153 7.7501 5.5448 1.3459
TM-31 CTRP2 6.6044 8.8604 4.2261 1.5662
Hs 683 CTRP2 6.6517 8.8812 5.0947 2.9609
YKG-1 CTRP2 6.6768 8.2299 5.423 1.6137
U-251MG CTRP2 6.7612 7.952 5.6009 0.8529
SF268 CTRP2 6.843 13.9951 2.7134 12.3657
CCF-STTG1 CTRP2 6.8986 8.3255 5.5125 1.0286
M059K CTRP2 6.9165 8.4007 4.5554 0.3159
42-MG-BA CTRP2 6.9334 21.237 -0.8243 23.5848
SNB-75 CTRP2 6.9777 10.9169 4.3354 5.5684
A-172 CTRP2 7.0205 11.3112 4.1735 6.1647
Becker CTRP2 7.1639 8.9836 5.3696 1.2699
8-MG-BA CTRP2 7.2315 8.9723 4.4706 0.3746
T98G CTRP2 7.2334 10.1629 4.8716 3.0515
YH-13 CTRP2 7.3512 8.6796 4.6187 0.1015
DK-MG CTRP2 7.8733 9.9085 5.3402 0.8023
SF539 CTRP2 8.5198 15.7173 3.0828 8.2984
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-1 CTRP2 5.7017 6.5124 5.4869 3.1011
HEC-1-A CTRP2 5.8509 7.8922 4.9547 4.9682
EN CTRP2 5.9319 7.3321 5.3046 3.3339
JHUEM-3 CTRP2 6.4737 8.9809 4.9168 3.9729
AN3-CA CTRP2 6.845 10.3355 4.524 5.0008
ESS-1 CTRP2 7.0873 8.9639 4.4142 0.5761
JHUEM-7 CTRP2 7.1109 10.9421 4.4173 5.0334
MFE-296 CTRP2 7.1789 10.5097 4.6718 3.912
MFE-319 CTRP2 7.3177 8.58 4.6407 0.0838
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 4.0936 8.4414 2.9905 17.1586
CAL-54 CTRP2 5.5792 7.7769 4.7653 6.3471
TUHR14TKB CTRP2 5.6388 11.4806 2.9813 26.3133
Caki-1 CTRP2 6.4903 9.3656 3.9368 2.8857
KMRC-2 CTRP2 6.4949 7.7951 5.51 1.5109
KMRC-3 CTRP2 6.5759 11.4714 3.7601 8.6096
RCC10RGB CTRP2 6.6656 9.7603 4.6753 4.661
ACHN CTRP2 6.8155 9.5835 4.869 3.6358
A-498 CTRP2 6.8306 8.1983 4.5955 0.2647
KMRC-1 CTRP2 7.2339 10.033 4.9328 2.8137
VMRC-RCZ CTRP2 7.2719 8.7705 4.5588 0.1968
Caki-2 CTRP2 7.5429 11.886 3.4132 3.7845
786-O CTRP2 7.6866 9.6747 5.3464 0.9094
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C2BBe1 CTRP2 4.2964 7.2969 3.6926 13.8767
COLO 678 CTRP2 4.3543 8.7424 3.117 15.9927
NCI-H747 CTRP2 4.5269 8.4951 3.4031 14.4196
COLO 320 CTRP2 5.3495 8.7161 4.093 9.6493
SW948 CTRP2 5.7144 7.8585 4.8495 5.6981
SW1417 CTRP2 5.7434 10.4814 3.5703 10.9795
T84 CTRP2 6.2638 8.7419 4.8739 4.5127
HCT 15 CTRP2 6.2916 7.4118 5.5541 1.6299
LS1034 CTRP2 6.3752 8.2755 5.1911 2.9967
SNU-503 CTRP2 6.4753 8.3063 5.2493 2.5965
HCT 8 CTRP2 6.645 7.7294 5.6341 0.8531
HCC-56 CTRP2 6.6915 8.0209 5.5292 1.1892
SNU-1033 CTRP2 7.229 34.2938 -7.1056 33.5102
SNU-C1 CTRP2 7.4351 10.7903 4.7061 3.439
GP2d CTRP2 7.8143 12.3561 4.2135 4.8709
NCI-H716 CTRP2 7.9597 12.4962 4.2408 4.5799
SNU-C4 CTRP2 8.0228 8.9489 5.7503 0.0256
RCM-1 [Human ESC] CTRP2 8.1395 10.9158 5.0536 1.4677
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 5.647 8.4522 4.4952 7.3217
HuH-1 CTRP2 5.7595 7.7875 4.2132 2.6962
SNU-475 CTRP2 6.1947 7.8432 4.4474 1.1302
JHH-1 CTRP2 6.5445 7.7146 4.6596 0.2384
HLF CTRP2 6.5977 10.5252 3.4652 4.8206
PLC/PRF/5 CTRP2 6.7015 8.153 4.5601 0.3984
SNU-387 CTRP2 6.7797 8.8432 5.2001 2.3553
JHH-6 CTRP2 6.7855 7.7143 4.748 0.0526
JHH-2 CTRP2 6.7877 8.9403 4.286 1.1773
SNU-449 CTRP2 6.9996 8.8087 5.3538 1.4955
SNU-423 CTRP2 7.5231 9.9977 5.1216 1.7876
JHH-4 CTRP2 7.5948 9.3493 5.4356 0.7133
SK-HEP-1 CTRP2 8.1377 11.3251 4.8769 2.0494
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DV-90 CTRP2 2.8748 6.3909 2.4848 22.4879
DMS 53 CTRP2 3.0773 7.5669 2.2926 22.5931
NCI-H1703 CTRP2 4.0197 7.9381 3.1346 16.7911
NCI-H146 CTRP2 4.3098 31.0091 -7.9113 38.6845
DMS 454 CTRP2 4.4775 10.1571 2.5709 17.8407
NCI-H1341 CTRP2 4.9532 8.6913 3.7293 12.0613
COLO 668 CTRP2 5.0265 8.6242 3.832 11.4682
NCI-H23 CTRP2 5.0989 8.0235 4.1877 9.8437
NCI-H810 CTRP2 5.5708 9.6483 3.834 10.2428
NCI-H1563 CTRP2 5.6975 7.6365 4.9435 5.3435
NCI-H1092 CTRP2 5.7021 8.1725 4.6832 6.4184
NCI-H1693 CTRP2 5.7744 10.5544 3.5606 10.957
EKVX CTRP2 5.9165 10.775 3.5717 10.6254
NCI-H841 CTRP2 5.9585 7.5259 5.2309 3.589
NCI-H1944 CTRP2 5.9745 9.275 4.3705 7.1715
SK-MES-1 CTRP2 6.0589 7.6226 5.2674 3.2382
NCI-H1694 CTRP2 6.1171 7.2415 5.5053 2.1296
NCI-H1568 CTRP2 6.2118 8.1105 5.1473 3.4599
NCI-H1105 CTRP2 6.2273 12.4468 2.2768 10.8903
NCI-H2196 CTRP2 6.3222 8.1364 5.22 2.9648
LUDLU-1 CTRP2 6.3232 7.9523 5.3116 2.5821
NCI-H2342 CTRP2 6.338 8.8983 4.8541 4.4644
ChaGo-K-1 CTRP2 6.3401 12.156 3.2314 11.2114
HOP-62 CTRP2 6.3568 10.3803 4.131 7.4569
NCI-H1793 CTRP2 6.3711 8.7503 4.9531 3.9939
NCI-H1915 CTRP2 6.3853 7.8056 5.4292 1.9975
COR-L95 CTRP2 6.4582 8.4658 5.1588 2.9957
NCI-H520 CTRP2 6.523 10.4321 4.2356 6.7261
NCI-H2081 CTRP2 6.5349 15.9348 1.5017 17.4178
RERF-LC-MS CTRP2 6.543 7.919 5.483 1.5532
DMS 114 CTRP2 6.5698 17.4342 0.7812 19.7366
NCI-H838 CTRP2 6.5843 8.4402 5.2611 2.3848
NCI-H322 CTRP2 6.5904 10.5785 3.4353 4.9662
NCI-H2029 CTRP2 6.6653 12.7742 3.1819 10.8191
HOP-92 CTRP2 6.7795 51.0522 -15.8499 40.0267
HCC2935 CTRP2 6.7824 8.9516 5.1503 2.5495
NCI-H2170 CTRP2 6.7857 8.834 5.2085 2.314
HCC1438 CTRP2 6.8763 8.7256 5.3174 1.7741
NCI-H647 CTRP2 6.9608 11.9784 3.8022 7.7828
DMS 273 CTRP2 6.9691 9.1548 4.2855 1.0343
NCI-H2110 CTRP2 7.0313 9.2988 5.1477 2.2357
NCI-H1339 CTRP2 7.072 8.9676 4.4062 0.6056
T3M-10 CTRP2 7.2767 9.3685 5.2623 1.5361
LK2 CTRP2 7.2806 8.3948 5.6712 0.283
HCC4006 CTRP2 7.2884 13.9603 3.0693 10.204
NCI-H1395 CTRP2 7.3783 9.678 5.182 1.7189
NCI-H1623 CTRP2 7.4872 13.0445 3.6617 7.5247
Calu-1 CTRP2 7.4897 10.973 4.6553 3.5672
COR-L51 CTRP2 7.495 10.8082 4.7355 3.2509
NCI-H1869 CTRP2 7.5135 10.3339 4.965 2.3639
Lu-65 CTRP2 7.7042 14.299 3.2052 9.009
NCI-H522 CTRP2 7.7119 18.16 1.3139 15.9528
IA-LM CTRP2 7.8142 10.379 5.1137 1.5435
KNS-62 CTRP2 7.8146 9.2513 5.5697 0.2814
VMRC-LCD CTRP2 8.156 9.7909 5.5072 0.282
LC-1/sq-SF CTRP2 8.2149 9.4264 5.6568 0.071
COR-L105 CTRP2 8.3973 16.3161 1.8976 8.9376
NCI-H2141 CTRP2 8.6233 21.7691 0.2141 17.9026
RERF-LC-Ad2 CTRP2 9.1538 16.1844 3.272 6.7675
NCI-H1651 CTRP2 10.8362 30.1899 -2.3054 20.9672
Hs 888.Lu CTRP2 6.6515 9.0241 5.0252 3.2446
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.1579 10.5382 3.8913 8.8266
Aska-SS CTRP2 6.3698 8.301 5.1745 3.0745
A-204 CTRP2 2.9497 8.6838 1.7053 25.0722
G-401 CTRP2 3.5553 6.4466 3.2083 17.8139
G-402 CTRP2 3.9581 7.2802 2.9291 12.9956
TE 617.T CTRP2 4.5767 7.2416 4.0095 11.8863
TE 441.T CTRP2 5.2813 7.3235 4.0957 4.1107
KYM-1 CTRP2 6.3228 8.6275 4.9769 3.9778
RD CTRP2 6.4054 11.1462 3.7878 8.7995
Tm87-16 CTRP2 6.436 11.9844 3.3941 10.369
GCT CTRP2 6.5787 9.886 4.5486 5.328
MES-SA CTRP2 6.8843 8.0152 4.6805 0.1096
SW982 CTRP2 6.9178 8.7366 5.3378 1.6473
Hs 729.T CTRP2 7.0042 9.5742 5.001 2.8422
TTC-709 CTRP2 7.008 11.5601 4.0426 6.721
BT-12 CTRP2 7.1306 7.83 5.8186 0.0688
SK-LMS-1 CTRP2 7.4433 9.3857 4.4028 0.4374
SK-UT-1 CTRP2 7.4498 9.0738 5.4788 0.6855
BT-16 CTRP2 7.7274 11.1879 4.7031 3.0977
HT-1080 CTRP2 7.7903 8.9683 5.6625 0.135
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.0341 8.1531 5.6561 0.4542
P-STS CTRP2 7.3154 13.6374 3.248 9.4502
SYO-1 CTRP2 8.1585 15.2358 3.069 8.8621
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 7.2859 20.8706 -0.3612 21.7517
TOV-21G CTRP2 4.8534 5.5405 4.6235 2.5175
OVCAR-5 CTRP2 5.238 9.1146 3.7946 11.1337
COV434 CTRP2 5.2515 7.3265 4.6635 7.541
COV644 CTRP2 5.4134 9.1843 3.9219 10.2166
OC 314 CTRP2 5.5712 6.1918 5.4814 3.4753
OV-90 CTRP2 5.905 8.9455 4.4761 6.8658
OV56 CTRP2 6.1328 8.7492 4.0014 3.0941
EFO-27 CTRP2 6.2068 10.4451 3.9779 8.373
OAW42 CTRP2 6.3513 7.6233 4.6136 0.4438
JHOS-2 CTRP2 6.4551 9.6053 4.5936 5.3499
EFO-21 CTRP2 6.5184 12.1807 3.3618 10.3517
OV7 CTRP2 6.5356 9.7425 3.7911 3.4584
OAW28 CTRP2 6.6628 10.5797 3.4812 4.6526
COV362 CTRP2 6.95 12.9379 3.3202 9.7649
TOV-112D CTRP2 7.0751 9.6625 5.0053 2.7328
JHOM-1 CTRP2 7.3223 9.2137 5.3553 1.1714
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 8.1987 9.8475 5.5033 0.2754
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 CTRP2 6.2873 9.7464 3.631 4.5413
MPP 89 CTRP2 7.3261 9.035 5.4338 0.912
JL-1 CTRP2 7.8562 9.7926 5.3788 0.7072
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 CTRP2 5.7152 10.0781 3.747 10.3035
VCaP CTRP2 6.4537 8.7389 5.0211 3.5729
LNCaP clone FGC CTRP2 6.7495 9.0485 5.0816 2.8715
DU145 CTRP2 7.017 8.8455 5.3474 1.5004
PaCa-3 CTRP2 7.5813 10.0182 5.1449 1.6496
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 6.8063 10.7981 3.4697 4.4973
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1 CTRP2 4.2922 7.2864 3.6925 13.8884
SNU-16 CTRP2 5.3397 6.4182 5.1486 5.3929
HGC-27 CTRP2 5.3802 9.6764 3.649 11.4203
KE-39 CTRP2 5.4439 11.1054 2.9976 13.9513
Hs 746.T CTRP2 5.7428 7.3201 4.4226 1.7738
NCC-StC-K140 CTRP2 5.7578 7.4213 5.1046 4.5405
IM95 CTRP2 5.8817 8.2628 4.7968 5.5666
HuG1-N CTRP2 6.059 9.0046 4.5765 6.1418
SNU-216 CTRP2 6.0795 9.9707 4.1104 8.0592
SNU-601 CTRP2 6.2099 8.2303 5.0861 3.7197
KATO III CTRP2 7.1562 9.1711 5.2816 1.5911
MKN7 CTRP2 7.1942 13.2604 3.3441 9.262
SH-10-TC CTRP2 7.4864 9.0688 5.4982 0.6077
LMSU CTRP2 7.7073 11.2156 4.6781 3.2153
MKN74 CTRP2 7.9028 18.6439 1.2184 15.9514
SNU-685 CTRP2 8.2301 9.4587 5.6512 0.074
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 4.8523 10.5194 2.7495 16.2556
TT2609-C02 CTRP2 6.1238 9.5595 3.6107 4.8964
FTC-238 CTRP2 7.0207 8.3518 4.613 0.1755
FTC-133 CTRP2 7.543 9.1128 5.5066 0.5511
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-4 CTRP2 5.3831 7.8352 4.5521 7.6776
BICR 6 CTRP2 5.6635 7.6729 4.8944 5.6229
BICR 56 CTRP2 5.7822 9.5789 4.0541 8.8837
BICR 31 CTRP2 5.9415 7.8942 5.0324 4.4567
CAL-27 CTRP2 5.9645 8.0028 4.2436 2.2554
BICR 18 CTRP2 6.1112 9.7247 4.2596 7.3732
CAL-33 CTRP2 6.1204 7.6771 5.2905 3.0252
PE/CA-PJ49 CTRP2 6.3392 7.331 5.6271 1.2602
BICR 22 CTRP2 6.4006 8.4652 5.1165 3.2645
HSC-2 CTRP2 6.6864 12.8413 2.4152 9.4348
SCC-9 CTRP2 6.7022 9.8582 3.8385 3.0339
PE/CA-PJ34 (clone C12) CTRP2 6.8048 8.4912 5.3817 1.6147
PE/CA-PJ41 (clone D2) CTRP2 6.8971 8.4467 5.4574 1.2272
BICR 16 CTRP2 6.9354 8.8103 5.3146 1.7143
FaDu CTRP2 7.1093 9.065 5.3022 1.5661
PE/CA-PJ15 CTRP2 7.1831 10.0122 4.9103 2.9652
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 5.6328 8.8498 4.2855 8.2277
SCaBER CTRP2 6.0641 9.1975 3.7439 4.3762
UM-UC-1 CTRP2 6.234 8.4393 5.0011 4.0328
HT-1197 CTRP2 6.582 8.4952 5.233 2.5021
BC-3C CTRP2 6.7797 8.2202 4.5671 0.346
647V CTRP2 7.1158 8.5051 4.5943 0.1808
J82 CTRP2 7.3775 9.6177 5.2084 1.6259
KMBC-2 CTRP2 7.6028 9.5002 5.3776 0.8762
T24 CTRP2 11.3998 22.5807 0.8353 9.0212
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4892 8.4262 5.7417 0.0944

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01425008) Study of MLN2480 in Patients With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Patients With Metastatic Melanoma. U.S. National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2184).