Details of the Drug

General Information of Drug (ID: DMBRVXB)

Drug Name
MW150
Synonyms
MW-150; 1628502-91-9; 6-(4-Methylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)pyridazine; MW150; 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-pyridazine; EPZ68T461K; CHEMBL4129018; 6-(4-methylpiperazin-1-yl)-3-naphthalen-2-yl-4-pyridin-4-ylpyridazine; MW01-18-150SRM; MW 150; 6-(4-Methyl-piperazin-1-yl)-(2-naphthalen-2-yl)-4-pyridin-4-ylpyridazine; Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-; UNII-EPZ68T461K; SCHEMBL16061104; EX-A3206A; GTPL10524; CIIVUDIZZJLXCN-UHFFFAOYSA-N; BDBM50537600; NSC785340; AKOS040758765; compound 8 [PMID: 25676389]; NSC-785340; compound 11 [PMID: 30978288]; compound 27 [WO2014145485A2]; MS-26255; HY-120111; CS-0069509; Q27453797; 3GF
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C24H23N5
Canonical SMILES
CN1CCN(CC1)C2=NN=C(C(=C2)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4
InChI
InChI=1S/C24H23N5/c1-28-12-14-29(15-13-28)23-17-22(19-8-10-25-11-9-19)24(27-26-23)21-7-6-18-4-2-3-5-20(18)16-21/h2-11,16-17H,12-15H2,1H3
InChIKey
CIIVUDIZZJLXCN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
86270361
ChEBI ID
CHEMBL4129018
TTD ID
D38LQO
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Stress-activated protein kinase (p38) TTWELHI NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT05194163) A Phase 2a Study of MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
2 p38alpha MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10245-E10254.