Details of the Drug

General Information of Drug (ID: DMBZMYT)

Drug Name
Pyridine derivative 18
Synonyms PMID27646564-Compound-5
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
D0AK1F

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fms-like tyrosine kinase 3 (FLT-3) TTGJCWZ FLT3_HUMAN Inhibitor [1]
Macrophage colony-stimulating factor 1 receptor (CSF1R) TT7MRDV CSF1R_HUMAN Inhibitor [1]
Platelet-derived growth factor receptor alpha (PDGFRA) TT8FYO9 PGFRA_HUMAN Inhibitor [1]
Platelet-derived growth factor receptor beta (PDGFRB) TTI7421 PGFRB_HUMAN Inhibitor [1]
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Inhibitor [1]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Inhibitor [1]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 6.79E-01 0.05 0.19
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 7.67E-01 0.61 0.61
Fms-like tyrosine kinase 3 (FLT-3) DTT FLT3 4.98E-01 -0.49 -0.75
Fms-like tyrosine kinase 3 (FLT-3) DTT FLT3 1.15E-01 -0.35 -0.75
Platelet-derived growth factor receptor alpha (PDGFRA) DTT PDGFRA 4.48E-02 1.37 3.31
Platelet-derived growth factor receptor alpha (PDGFRA) DTT PDGFRA 9.98E-03 2.15 1.46
Proto-oncogene c-Src (SRC) DTT SRC 6.45E-01 -0.08 -0.58
Proto-oncogene c-Src (SRC) DTT SRC 2.08E-03 -0.52 -1.62
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99.