Details of the Drug

General Information of Drug (ID: DMC1BXV)

Drug Name
AZD-3514
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 519.6
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C25H32F3N7O2
IUPAC Name
1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone
Canonical SMILES
CC(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5C(F)(F)F)CC4
InChI
InChI=1S/C25H32F3N7O2/c1-18(36)33-14-12-32(13-15-33)16-17-37-21-4-2-19(3-5-21)20-8-10-34(11-9-20)23-7-6-22-29-30-24(25(26,27)28)35(22)31-23/h2-5,20H,6-17H2,1H3
InChIKey
JMEYDSHPKCSIJC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46893585
CAS Number
1240299-33-5
TTD ID
D08AAV

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Androgen receptor (AR) TTS64P2 ANDR_HUMAN Antagonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Prostate cancer
ICD Disease Classification 2C82.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Androgen receptor (AR) DTT AR 2.13E-01 -0.07 -0.11
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 5.0098 7.1367 2.5699 1.9493
NOS-1 [Human HNSCC] GDSC1 1.2394 19.6849 -6.6539 44.4184
EW-11 GDSC1 2.2001 9.6785 -0.8337 31.7813
TC-71 GDSC1 3.1205 6.4805 1.5718 14.4332
EW-22 GDSC1 3.1792 6.3334 1.6956 13.2772
CHSA0108 GDSC1 3.3962 6.1401 1.9742 10.3385
MG-63 GDSC1 3.4606 10.7901 -0.2973 24.5595
HOS GDSC1 3.5806 6.6411 1.8727 10.4808
HuO9 GDSC1 3.7509 8.3081 1.1767 14.9856
EW-3 GDSC1 3.7725 6.7618 1.9615 9.1701
ES8 GDSC1 3.8508 7.995 1.4102 13.0127
A-673 GDSC1 3.8797 6.8751 1.986 8.6481
ES5 GDSC1 3.9175 8.0403 1.4389 12.5899
ES7 GDSC1 3.9302 8.3567 1.2917 13.5909
CADO-ES1 GDSC1 3.9833 7.6454 1.6836 10.5997
CHSA0011 GDSC1 3.9949 10.5412 0.2567 19.8712
MHH-ES-1 GDSC1 4.0147 6.3545 2.337 5.5848
EW-24 GDSC1 4.113 9.5356 0.8472 15.9699
CHSA8926 GDSC1 4.1496 6.245 2.4792 4.1775
SJSA-1 GDSC1 4.2668 7.412 2.0007 7.4196
ES1 GDSC1 4.2801 6.5369 2.4256 4.257
EW-16 GDSC1 4.3996 12.2208 -0.2644 21.2696
ES4 GDSC1 4.4319 10.7947 0.4654 17.2891
CAL-72 GDSC1 4.5083 14.1902 -1.1579 24.8062
SaOS-2 GDSC1 4.5431 10.425 0.7295 15.374
NY GDSC1 4.5919 9.3495 1.2897 11.5993
SK-ES-1 GDSC1 4.6312 8.1399 1.8972 7.2265
SK-PN-DW GDSC1 4.7078 7.9975 2.0135 6.2115
EW-13 GDSC1 4.8349 7.7233 2.2177 4.5046
HuO-3N1 GDSC1 5.0936 10.6098 1.0278 11.9595
U2OS GDSC1 5.3696 8.5216 2.165 3.8403
EW-1 GDSC1 5.4575 7.7871 2.5186 1.6588
EW-7 GDSC1 5.4837 7.762 2.5407 1.5182
G-292 clone A141B1 GDSC1 5.6695 7.517 2.7137 0.6252
EW-18 GDSC1 5.7197 8.1985 2.4745 1.589
H-EMC-SS GDSC1 6.319 8.7748 2.5096 0.9244
ES6 GDSC1 6.4687 8.4542 2.6818 0.3419
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 153 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.8165 6.8734 1.1092 18.9771
WSU-DLCL2 GDSC1 -2.099 -1.2821 -2.099 67.7569
EHEB GDSC1 -1.5013 14.3173 -6.5755 52.7847
A3/Kawakami GDSC1 0.6095 4.8201 -0.1491 37.6413
MOLM-16 GDSC1 1.2037 6.08 -0.0635 33.6203
MV4-11 GDSC1 1.4277 3.4574 1.2161 25.0605
DG-75 GDSC1 1.6153 5.3618 0.6757 27.4794
HH [Human lymphoma] GDSC1 1.6369 6.2409 0.2976 29.4934
MOLT-16 GDSC1 1.6372 4.709 0.9808 25.4492
SU-DHL-5 GDSC1 1.6421 7.2374 -0.166 31.7083
Kasumi-1 GDSC1 1.8289 5.8696 0.6601 26.4506
BC-1 GDSC1 1.8519 4.7722 1.1769 23.0022
RPMI-8402 GDSC1 2.071 7.753 -0.0064 28.867
CTB-1 GDSC1 2.0948 11.7627 -1.9602 35.6361
P30/OHK GDSC1 2.1248 4.4859 1.5825 18.7527
NCI-H929 GDSC1 2.1258 5.3941 1.175 21.6373
MOLM-13 GDSC1 2.1514 4.4117 1.6418 18.1901
DB GDSC1 2.2146 7.7933 0.1075 27.6329
MOLT-4 GDSC1 2.2249 7.6345 0.1948 27.1353
L-363 GDSC1 2.5384 5.713 1.4238 17.9497
MOLT-13 GDSC1 2.5961 5.7158 1.4769 17.3064
Mono-Mac-6 GDSC1 2.6126 8.0557 0.3407 24.623
MLMA GDSC1 2.6406 7.716 0.5342 23.3946
Ku812 GDSC1 2.6967 6.2747 1.2968 18.1717
ALL-SIL GDSC1 2.7187 5.225 1.8305 14.1241
LC4-1 GDSC1 2.7423 6.0578 1.4452 16.9055
MHH-PREB-1 GDSC1 2.7575 5.1839 1.8869 13.5257
TUR GDSC1 2.811 13.5272 -2.2125 33.6449
697 GDSC1 2.8182 5.3523 1.8615 13.4608
MOLP-8 GDSC1 2.8923 5.0215 2.0921 11.3712
Karpas-620 GDSC1 2.9024 11.6215 -1.1824 30.2254
H9 GDSC1 2.9561 4.3085 2.4983 7.9537
MC116 GDSC1 2.9753 7.8395 0.7682 20.5731
SU-DHL-10 GDSC1 3.0109 3.9399 2.7267 5.957
NALM-6 GDSC1 3.0296 5.6317 1.9152 12.178
HAL-01 GDSC1 3.0341 6.0777 1.6974 13.8278
NB4 GDSC1 3.0405 5.9598 1.7616 13.3145
SR GDSC1 3.049 5.3677 2.0635 10.9505
OCI-AML-2 GDSC1 3.0519 4.7967 2.3489 8.7105
GA-10 GDSC1 3.1071 5.7218 1.9386 11.6927
NOMO-1 GDSC1 3.1088 4.8106 2.3933 8.1341
EoL-1 GDSC1 3.1504 5.0369 2.3176 8.563
MEG-01 GDSC1 3.1954 6.9359 1.4084 15.3484
Karpas-45 GDSC1 3.1971 5.5603 2.097 10.1134
BV-173 GDSC1 3.2018 6.1868 1.7882 12.4867
GR-ST GDSC1 3.207 5.8686 1.9516 11.2081
Reh GDSC1 3.2216 9.2741 0.2618 22.5965
CMK GDSC1 3.2872 5.6863 2.1107 9.6698
A4/Fukuda GDSC1 3.2964 6.5896 1.6667 13.0554
CRO-AP2 GDSC1 3.3154 5.199 2.3779 7.4677
JSC-1 GDSC1 3.3403 6.1207 1.9378 10.8216
CA46 GDSC1 3.342 5.4805 2.2594 8.3044
SKM-1 GDSC1 3.344 6.6588 1.6719 12.8413
KCL-22 GDSC1 3.3666 5.6512 2.1943 8.7268
Loucy GDSC1 3.3801 8.2243 0.9191 18.037
HEL GDSC1 3.3931 5.5259 2.2786 7.9712
AMO1 GDSC1 3.3985 5.5543 2.2689 8.0286
JVM-2 GDSC1 3.4035 7.616 1.2425 15.7556
SUP-M2 GDSC1 3.424 5.3661 2.3836 7.0373
WSU-NHL GDSC1 3.4327 6.3764 1.886 10.8902
HC-1 GDSC1 3.4351 7.1499 1.5014 13.7802
BL-41 GDSC1 3.4607 5.9372 2.128 8.9152
P32/ISH GDSC1 3.4691 5.9405 2.1332 8.8453
NKM-1 GDSC1 3.4692 6.5719 1.818 11.2833
JJN-3 GDSC1 3.4697 7.9302 1.1397 16.2282
JVM-3 GDSC1 3.4712 7.2725 1.4696 13.883
Daudi GDSC1 3.5182 6.6187 1.8342 10.9888
SU-DHL-8 GDSC1 3.5317 6.3069 2.0005 9.663
RPMI-8226 GDSC1 3.5524 6.3071 2.0168 9.4667
WIL2 NS GDSC1 3.5564 5.9931 2.1763 8.2126
OCI-AML-3 GDSC1 3.5634 6.1822 2.0877 8.879
Raji GDSC1 3.5733 6.727 1.824 10.877
Sc-1 GDSC1 3.5976 7.8549 1.2808 14.7906
Jiyoye GDSC1 3.6122 7.3701 1.5344 12.9144
KMS-11 GDSC1 3.6506 7.1631 1.6679 11.7929
SU-DHL-16 GDSC1 3.7138 7.0772 1.7601 10.8903
RL GDSC1 3.7239 6.6921 1.959 9.345
EM-2 GDSC1 3.7492 8.632 1.014 16.093
OCI-AML-5 GDSC1 3.8164 6.0331 2.3531 6.0225
L-540 GDSC1 3.8221 6.7792 1.9904 8.7931
HDLM-2 GDSC1 3.8318 12.2026 -0.701 25.082
ST486 GDSC1 3.834 6.3086 2.2309 6.911
EJM GDSC1 3.8366 9.1688 0.8156 17.0849
P31/FUJ GDSC1 3.8429 8.2374 1.2837 13.9335
RS4;11 GDSC1 3.8608 8.3773 1.2281 14.2615
CESS GDSC1 3.8693 6.2065 2.3065 6.2264
KMOE-2 GDSC1 3.8805 6.4961 2.1729 7.2172
MN-60 GDSC1 3.912 7.9329 1.4879 12.2551
THP-1 GDSC1 3.9128 8.1702 1.3709 13.0903
Karpas-231 GDSC1 3.9258 6.7247 2.0938 7.6873
Namalwa GDSC1 3.9461 6.635 2.1524 7.1811
CCRF-CEM GDSC1 3.9491 9.2085 0.8836 16.2721
Karpas-299 GDSC1 4.0054 9.1622 0.95 15.6563
ALL-PO GDSC1 4.0161 12.0373 -0.4716 23.4643
RPMI-6666 GDSC1 4.0169 7.825 1.6201 10.9621
IM-9 GDSC1 4.0331 7.6464 1.72 10.1777
L-1236 GDSC1 4.0684 8.1113 1.5173 11.5495
PL-21 GDSC1 4.0758 8.6116 1.2761 13.2328
ML-2 GDSC1 4.1087 6.5297 2.3169 5.4844
OCI-M1 GDSC1 4.1088 9.0362 1.0911 14.3901
ARH-77 GDSC1 4.1127 6.7888 2.1951 6.3876
SU-DHL-6 GDSC1 4.1182 6.0641 2.5441 3.7785
Ramos.2G6.4C10 GDSC1 4.1309 8.3841 1.4293 11.9856
JeKo-1 GDSC1 4.1453 11.8123 -0.258 22.0422
ME1 GDSC1 4.1996 8.4809 1.4324 11.7547
BALL-1 GDSC1 4.2135 7.5395 1.902 8.2992
KOPN-8 GDSC1 4.2251 9.0052 1.1934 13.3357
Hs 445 GDSC1 4.2272 6.4007 2.4557 4.1634
KE-37 GDSC1 4.2337 9.8716 0.7725 16.0569
HL-60 GDSC1 4.241 8.2844 1.5587 10.7303
GDM-1 GDSC1 4.2436 10.3996 0.5188 17.5651
K-562 GDSC1 4.2469 12.9057 -0.7226 23.8344
Jurkat GDSC1 4.2488 9.3046 1.0635 14.1347
U-698-M GDSC1 4.2543 11.123 0.1685 19.5096
YT GDSC1 4.2583 6.2019 2.5673 3.2926
KY821 GDSC1 4.2637 6.8594 2.263 5.4851
DND-41 GDSC1 4.2922 6.3567 2.5167 3.5763
OPM-2 GDSC1 4.3022 6.1983 2.5953 3.0036
P12-Ichikawa GDSC1 4.3173 8.3803 1.5667 10.4499
QIMR-WIL GDSC1 4.3312 8.987 1.2802 12.4208
CML-T1 GDSC1 4.3609 16.7832 -2.5637 29.7785
ATN-1 GDSC1 4.3738 9.0442 1.2831 12.2744
OCI-Ly7 GDSC1 4.3885 5.9659 2.7473 1.8311
RCH-ACV GDSC1 4.3972 10.9571 0.3592 18.0048
OCI-Ly19 GDSC1 4.446 10.3544 0.6928 15.8913
LP-1 GDSC1 4.4811 6.6842 2.4803 3.4285
SK-MM-2 GDSC1 4.4946 7.0773 2.3082 4.6065
SUP-T1 GDSC1 4.5053 9.2998 1.2526 12.0987
SUP-B8 GDSC1 4.5402 9.5496 1.1558 12.6491
TK [Human B-cell lymphoma] GDSC1 4.5512 6.8207 2.4597 3.4272
NU-DUL-1 GDSC1 4.5534 6.3198 2.6822 1.9665
HT GDSC1 4.5696 10.3311 0.7949 14.8908
JURL-MK1 GDSC1 4.6832 11.9551 0.0806 18.6608
LAMA-84 GDSC1 4.7249 10.0591 1.0388 12.8912
SUP-HD1 GDSC1 4.7407 7.8035 2.1242 5.3551
RC-K8 GDSC1 4.7553 9.5931 1.2856 11.1747
Karpas-422 GDSC1 4.9093 13.4778 -0.5015 20.8679
L-428 GDSC1 4.9495 6.993 2.5998 1.8624
BE-13 GDSC1 4.972 7.2093 2.5201 2.2961
VAL GDSC1 4.9774 7.3736 2.4527 2.699
MHH-CALL-2 GDSC1 4.9785 7.4843 2.4053 2.9941
SU-DHL-4 GDSC1 4.9958 6.4384 2.8417 0.6173
Karpas-1106P GDSC1 5.0626 6.9904 2.6554 1.4129
Farage GDSC1 5.0713 7.0466 2.6368 1.5003
VL51 GDSC1 5.102 11.917 0.4024 15.7011
Granta-519 GDSC1 5.1144 7.9033 2.2963 3.4519
CTV-1 GDSC1 5.1868 16.8138 -1.9399 25.6824
EB2 GDSC1 5.5507 7.2913 2.7494 0.5769
PF-382 GDSC1 5.609 7.7632 2.5959 1.1346
KM-H2 GDSC1 5.7381 14.0984 -0.2098 17.2412
ROS-50 GDSC1 6.377 14.2389 0.1512 13.8747
DEL GDSC1 6.5513 14.3302 0.22 13.1251
U266B1 GDSC1 6.8804 19.4841 -2.0201 21.8817
⏷ Show the Full List of 153 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 4.021 7.0281 2.0143 8.0106
ESO-51 GDSC1 4.0627 13.4079 -1.1178 26.0154
SK-GT-4 GDSC1 4.1485 8.9459 1.1656 13.7626
FLO-1 GDSC1 4.2807 7.3094 2.0596 6.9462
KYSE-50 GDSC1 4.3703 23.755 -6.0346 36.2886
HCE-4 GDSC1 4.4109 8.3989 1.6238 9.7742
KYAE-1 GDSC1 4.4884 10.0361 0.8804 14.5952
OACM5.1 C GDSC1 4.6793 8.7269 1.6498 8.8636
TE-12 GDSC1 4.6978 7.998 2.0069 6.2821
OACP4 C GDSC1 4.8141 9.8713 1.192 11.6399
KYSE-220 GDSC1 6.0954 8.0368 2.6906 0.4684
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.4841 8.4669 1.6418 9.4423
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC1 2.4598 9.3234 -0.4245 29.0401
GI-ME-N GDSC1 2.5207 6.7404 0.9063 21.6072
SJNB-10 GDSC1 2.7499 6.7639 1.1037 19.2945
SK-N-DZ GDSC1 3.2839 8.9962 0.453 21.2788
GOTO GDSC1 3.3764 6.0338 2.0111 10.1235
NB69 GDSC1 3.4027 5.7649 2.1671 8.8122
NB1 GDSC1 3.4368 6.9081 1.6237 12.8676
IMR-5 GDSC1 3.5926 7.6855 1.3615 14.2357
SK-N-BE(2)-M17 GDSC1 3.6259 6.3487 2.0538 8.9343
SJNB-17 GDSC1 3.7939 8.0351 1.3462 13.6566
KP-N-YN GDSC1 3.92 6.8715 2.0175 8.2859
SK-N-SH GDSC1 3.9638 5.8624 2.5386 4.2029
SK-N-FI GDSC1 3.9711 8.7841 1.1112 14.6985
SJNB-6 GDSC1 4.0871 6.6112 2.2631 5.9457
Kelly GDSC1 4.0874 6.3781 2.3751 5.1051
SK-N-MC-IXC GDSC1 4.2642 5.7386 2.7791 1.8417
NH-12 GDSC1 4.3138 8.1346 1.6838 9.6162
SJNB-7 GDSC1 4.4073 11.4523 0.1221 19.2782
SJNB-13 GDSC1 4.4275 6.3247 2.6111 2.6466
SJNB-5 GDSC1 4.554 9.8797 1.0045 13.6047
TGW GDSC1 4.6334 6.4481 2.6691 1.9197
SJNB-14 GDSC1 4.756 6.456 2.7273 1.4076
SK-N-AS GDSC1 4.8949 6.7751 2.6633 1.5793
SiMa GDSC1 4.8955 7.6807 2.2722 4.0142
CHP-126 GDSC1 5.4547 7.3276 2.6969 0.8387
LA-N-6 GDSC1 5.4582 7.3107 2.7047 0.8047
NB(TU)1 GDSC1 5.9122 7.9113 2.6653 0.6412
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 3.3711 5.7841 2.1316 9.2022
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BT-20 GDSC1 0.2656 192.0232 -93.5875 49.7297
HCC1599 GDSC1 0.4886 17.4058 -6.2012 46.3012
OCUB-M GDSC1 2.5654 6.6265 1.0034 20.7692
HCC1500 GDSC1 3.2953 6.4049 1.7582 12.3659
HCC2157 GDSC1 3.3517 7.1267 1.4443 14.5014
MCF-7 GDSC1 3.3734 5.952 2.0495 9.8346
CAL-120 GDSC1 3.4374 7.0312 1.5626 13.3195
EFM-192A GDSC1 3.4952 5.3238 2.4615 6.1836
MDA-MB-436 GDSC1 3.498 6.081 2.0863 9.1117
Evsa-T GDSC1 3.559 5.6851 2.3317 6.9899
MDA-MB-468 GDSC1 3.5832 5.7291 2.3286 6.9349
HCC2218 GDSC1 3.6176 8.0146 1.2172 15.1661
EFM-19 GDSC1 3.6809 11.1035 -0.2739 23.6715
MDA-MB-231 GDSC1 3.6866 6.1035 2.2221 7.4327
JIMT-1 GDSC1 3.7329 6.0117 2.3023 6.6663
MDA-MB-453 GDSC1 3.7412 6.41 2.1119 8.1136
HCC1187 GDSC1 3.9234 6.0659 2.4132 5.2578
BT-474 GDSC1 3.9287 6.5144 2.1988 6.8776
CAL-85-1 GDSC1 3.9367 7.6829 1.6302 11.1388
HDQ-P1 GDSC1 3.9371 8.8351 1.0597 15.1557
Hs 578T GDSC1 3.9763 6.9957 1.9977 8.2677
DU4475 GDSC1 3.9939 9.2678 0.8887 16.0917
MDA-MB-157 GDSC1 4.0002 6.5243 2.2447 6.3233
MDA-MB-361 GDSC1 4.0162 6.2599 2.3836 5.2295
MDA-MB-415 GDSC1 4.0498 8.758 1.1841 13.9486
HCC1419 GDSC1 4.1602 6.316 2.4526 4.3466
CAMA-1 GDSC1 4.1734 6.2078 2.5118 3.8828
MRK-nu-1 GDSC1 4.1917 7.1072 2.096 6.9152
HCC1806 GDSC1 4.2156 7.6485 1.8506 8.6735
COLO 824 GDSC1 4.2944 6.9593 2.2358 5.6084
CAL-51 GDSC1 4.3085 6.3607 2.5248 3.4836
T-47D GDSC1 4.3375 9.1206 1.2192 12.8188
HCC202 GDSC1 4.4769 12.376 -0.2823 21.1175
UACC-893 GDSC1 4.6333 18.5181 -3.2129 30.6847
HCC70 GDSC1 4.6664 6.9529 2.4667 3.1556
MDA-MB-175-VII GDSC1 4.6789 6.5753 2.6385 2.0346
MFM-223 GDSC1 4.679 6.7564 2.5603 2.5227
HCC1143 GDSC1 4.6811 7.6109 2.1765 5.1205
HCC1937 GDSC1 4.6853 8.2729 1.8696 7.2895
AU565 GDSC1 4.7 7.0517 2.4417 3.2582
HCC1428 GDSC1 4.8398 9.6981 1.293 10.8969
HCC38 GDSC1 4.9545 10.8848 0.7996 13.7633
MDA-MB-330 GDSC1 5.0181 7.3373 2.4895 2.4096
HCC1569 GDSC1 5.0777 9.0572 1.752 7.1768
HCC1395 GDSC1 5.1162 7.258 2.5718 1.7944
BT-483 GDSC1 5.2156 7.5964 2.4804 2.1734
BT-549 GDSC1 5.6501 15.2216 -0.8169 20.2518
HCC1954 GDSC1 5.6583 7.637 2.6647 0.8108
ZR-75-30 GDSC1 5.807 7.4243 2.7992 0.3093
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H4 GDSC1 3.1492 6.1819 1.7456 13.0125
GI-1 GDSC1 3.4623 5.2632 2.4657 6.2608
D-263MG GDSC1 3.5446 7.0065 1.6617 12.2026
8-MG-BA GDSC1 3.5763 5.4218 2.4757 5.8065
MOG-G-UVW GDSC1 3.6358 6.1602 2.1551 8.1159
Becker GDSC1 3.6867 5.7029 2.4201 5.8941
NMC-G1 GDSC1 3.7562 6.4251 2.1157 8.0368
D-566MG GDSC1 3.7853 8.2568 1.2292 14.5067
LN-18 GDSC1 3.8201 5.7928 2.473 5.0909
PFSK-1 GDSC1 3.856 6.0635 2.3667 5.8028
KS-1 [Human Krukenberg tumour] GDSC1 3.899 7.6372 1.6243 11.3014
M059J GDSC1 3.9118 5.9737 2.4496 5.0128
D-542MG GDSC1 3.912 7.7794 1.5638 11.7033
D283 Med GDSC1 3.9369 7.2926 1.8229 9.706
SK-MG-1 GDSC1 3.9402 5.993 2.4599 4.8576
SF539 GDSC1 3.9608 15.8634 -2.4247 30.5477
SF268 GDSC1 3.9631 6.9291 2.0208 8.1322
YKG-1 GDSC1 3.9661 6.2737 2.3423 5.6781
DK-MG GDSC1 3.9702 8.8369 1.0843 14.8822
CAS-1 GDSC1 4 7.4163 1.8087 9.619
KNS-42 GDSC1 4.0092 8.0525 1.5021 11.8434
MOG-G-CCM GDSC1 4.0208 7.1788 1.9404 8.5687
Onda 10 GDSC1 4.0587 7.1296 1.9917 8.0712
YH-13 GDSC1 4.0725 7.7788 1.6838 10.3246
SF126 GDSC1 4.1898 6.4158 2.4247 4.4796
U-118MG GDSC1 4.2067 8.1168 1.6159 10.4192
U-251MG GDSC1 4.2202 6.8985 2.2155 5.9482
ONS-76 GDSC1 4.2523 7.4886 1.9538 7.8072
GaMG GDSC1 4.2837 9.8552 0.8181 15.6141
SNB-75 GDSC1 4.3092 7.6798 1.9008 8.0423
Daoy GDSC1 4.3391 7.3775 2.0664 6.7424
KNS-81-FD GDSC1 4.3415 10.3372 0.6235 16.6333
SF295 GDSC1 4.4243 15.3317 -1.7908 27.3019
LNZTA3WT4 GDSC1 4.4601 7.1494 2.2532 5.0795
U-87MG ATCC GDSC1 4.5752 9.8965 1.0116 13.4966
LN-229 GDSC1 4.7394 8.6929 1.7061 8.3121
D-336MG GDSC1 4.755 10.9785 0.6123 15.4609
D-423MG GDSC1 4.7697 9.233 1.4685 9.8892
A-172 GDSC1 4.7735 7.0593 2.4793 2.8769
KALS-1 GDSC1 4.9543 9.0748 1.6655 8.0621
D-502MG GDSC1 5.0252 10.172 1.1913 11.0823
SW1088 GDSC1 5.137 11.7944 0.4864 15.1264
AM-38 GDSC1 5.1448 10.6467 1.0447 11.7186
42-MG-BA GDSC1 5.1577 12.1271 0.3396 15.9005
D-247MG GDSC1 5.1685 7.6086 2.4516 2.4084
Hs 683 GDSC1 5.2344 6.6787 2.8486 0.4361
GB-1 GDSC1 5.4255 13.164 0.0246 16.8716
SW1783 GDSC1 5.4292 12.0092 0.5842 13.7876
D-392MG GDSC1 5.4445 8.1937 2.3449 2.628
DBTRG-05MG GDSC1 5.581 7.3543 2.7383 0.596
Onda 11 GDSC1 5.6923 7.9674 2.553 1.2488
T98G GDSC1 6.1606 14.3082 -0.0237 15.2748
LN-405 GDSC1 6.2662 21.3434 -3.3683 27.1643
KINGS-1 GDSC1 6.4284 8.235 2.7427 0.2323
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 3.3483 6.497 1.7563 12.1863
TGBC24TKB GDSC1 3.6876 6.2873 2.1319 8.1295
TGBC1TKB GDSC1 4.0335 6.3838 2.3358 5.5432
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1 3.8558 7.5012 1.6588 11.1851
MFE-280 GDSC1 3.9055 8.6221 1.1411 14.7109
MFE-319 GDSC1 4.2425 12.8456 -0.6962 23.7346
AN3-CA GDSC1 4.6024 8.3979 1.7555 8.3139
RL95-2 GDSC1 5.0707 10.6312 1.002 12.1842
MFE-296 GDSC1 5.4532 11.9865 0.6113 13.5684
ESS-1 GDSC1 5.5136 7.3563 2.7104 0.7413
EN GDSC1 5.6003 7.0163 2.8659 0.2314
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 GDSC1 0.7254 4.3017 0.1711 35.4923
LB2241-RCC GDSC1 2.6803 6.9049 0.9712 20.4841
SW13 GDSC1 3.0097 6.552 1.4398 15.844
Caki-1 GDSC1 3.2635 9.9747 -0.0533 24.0964
LB996-RCC GDSC1 3.4629 6.4805 1.8585 10.9954
769-P GDSC1 3.4916 7.2533 1.4958 13.6191
CAL-54 GDSC1 3.5206 6.0384 2.1255 8.7299
KTCTL-195 GDSC1 3.7495 5.8467 2.3957 5.8929
TK-10 GDSC1 3.7941 6.2161 2.2471 6.9065
BFTC-909 GDSC1 3.9368 7.4626 1.739 10.3333
HA7-RCC GDSC1 4.0068 11.144 -0.034 21.3799
ACHN GDSC1 4.011 8.3969 1.3333 13.0392
RCC10RGB GDSC1 4.0535 6.9879 2.0571 7.5929
A-498 GDSC1 4.1847 6.0392 2.5973 3.2418
SN12C GDSC1 4.2148 10.2782 0.557 17.4309
SW156 GDSC1 4.2194 7.0111 2.161 6.3558
KMRC-1 GDSC1 4.2929 6.9815 2.2243 5.6974
LB1047-RCC GDSC1 4.4209 7.1903 2.209 5.4922
KTCTL-1M GDSC1 4.4571 8.7054 1.5075 10.4707
KTCTL-26A GDSC1 4.4853 10.8033 0.501 16.9182
A-704 GDSC1 4.5373 7.0929 2.3273 4.3763
OS-RC-2 GDSC1 4.5664 7.7994 2.016 6.5339
VMRC-RCZ GDSC1 4.6259 6.7622 2.5285 2.8226
NCC010 GDSC1 4.8316 10.8666 0.7217 14.5829
BB65-RCC GDSC1 4.9637 7.4028 2.4327 2.8464
KTCTL-140 GDSC1 5.012 7.3978 2.4604 2.5953
786-O GDSC1 5.0243 6.8581 2.6908 1.2756
KTCTL-21 GDSC1 5.1865 17.498 -2.2785 26.7462
KMRC-20 GDSC1 5.3514 7.8647 2.436 2.238
KTCTL-13 GDSC1 5.6089 8.2548 2.4003 2.0968
RXF 393L GDSC1 6.3536 9.0141 2.4341 1.188
NCC021 GDSC1 6.4951 12.5418 1.0111 8.8491
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CaR-1 GDSC1 -0.5215 41.8027 -19.2083 49.7975
HCT 116 GDSC1 2.6081 6.0273 1.3364 18.2721
SW48 GDSC1 3.3693 6.0686 1.9878 10.3296
RKO GDSC1 3.398 5.1872 2.4519 6.5907
NCI-H508 GDSC1 3.5496 6.8928 1.7225 11.7279
SW626 GDSC1 3.5668 6.3568 2.0034 9.5214
HT-29 GDSC1 3.6204 5.914 2.2655 7.3072
SNU-407 GDSC1 3.6329 6.2706 2.098 8.5686
NCI-H747 GDSC1 3.6383 6.6339 1.9217 9.9111
LS411N GDSC1 3.7193 17.821 -3.5992 33.9716
RCM-1 [Human ESC] GDSC1 3.8768 6.2188 2.3059 6.2091
LS180 GDSC1 3.8843 10.1753 0.3518 19.7102
LoVo GDSC1 3.8967 8.6488 1.121 14.8769
CL-11 GDSC1 3.926 6.9446 1.986 8.5073
SNU-C5 GDSC1 3.9282 6.8799 2.0194 8.2466
CCK-81 GDSC1 3.9538 7.411 1.7771 9.9961
SW837 GDSC1 3.9829 6.8921 2.0533 7.8269
COLO205 GDSC1 3.9921 9.3138 0.8645 16.2527
MDST8 GDSC1 4.0545 6.1547 2.4597 4.5584
SNU-C1 GDSC1 4.0817 10.3352 0.4266 18.6248
SW1463 GDSC1 4.1967 7.2469 2.032 7.3791
GP5d GDSC1 4.2559 6.6547 2.3548 4.83
SNU-1040 GDSC1 4.2608 7.2517 2.0737 6.8948
LS123 GDSC1 4.3341 11.0137 0.2835 18.6268
HT-55 GDSC1 4.375 8.5199 1.5397 10.4762
LS513 GDSC1 4.386 6.7469 2.3941 4.2399
LS1034 GDSC1 4.3946 6.8139 2.3683 4.4045
SW1417 GDSC1 4.5367 7.6193 2.0817 6.1331
HT115 GDSC1 4.6046 6.3639 2.6901 1.8371
SW1116 GDSC1 4.6407 8.6877 1.6426 9.0152
SW620 GDSC1 4.753 6.5456 2.6887 1.6278
NCI-H716 GDSC1 4.7858 13.4173 -0.5638 21.5082
CW-2 GDSC1 4.7941 7.9935 2.0693 5.6208
SK-CO-1 GDSC1 4.9037 6.4447 2.7999 0.8742
SNU-81 GDSC1 4.9084 7.3444 2.4282 2.9686
COLO 320HSR GDSC1 5.1166 7.5843 2.4352 2.5843
SNU-C2B GDSC1 5.1207 19.744 -3.4424 29.9985
SW948 GDSC1 5.1903 22.2229 -4.6202 32.2703
T84 GDSC1 5.3321 7.2838 2.6612 1.0987
HCT 15 GDSC1 5.4811 6.9603 2.8418 0.3339
SNU-61 GDSC1 5.4888 7.6348 2.5932 1.2602
C2BBe1 GDSC1 5.6143 8.01 2.5015 1.5696
HCC2998 GDSC1 5.6487 14.8219 -0.6232 19.4076
KM12 GDSC1 5.7434 7.3459 2.8033 0.3237
COLO 678 GDSC1 5.997 19.7182 -2.7677 26.1808
DiFi GDSC1 6.1469 8.4656 2.5548 0.877
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.9045 6.411 2.2319 6.6946
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1 3.3006 5.9965 1.9668 10.742
JHH-6 GDSC1 3.3216 8.868 0.5486 20.5742
JHH-1 GDSC1 3.3657 5.2309 2.4036 7.0845
Hep-G2/C3A GDSC1 3.5643 5.5412 2.4073 6.3811
JHH-7 GDSC1 3.6265 5.356 2.5462 5.0993
JHH-4 GDSC1 3.7076 7.4425 1.5735 12.3016
SNU-423 GDSC1 3.9372 13.0867 -1.0577 26.184
HuH-1 GDSC1 3.9804 6.2631 2.3573 5.5246
JHH-2 GDSC1 4.0028 14.6493 -1.7848 28.5379
SNU-398 GDSC1 4.0634 8.3515 1.3951 12.4378
Huh-7 GDSC1 4.3046 7.48 1.9939 7.3685
SK-HEP-1 GDSC1 4.3899 8.2655 1.6737 9.4744
SNU-387 GDSC1 4.4824 6.3688 2.6224 2.4696
HLE GDSC1 4.8198 12.9856 -0.3255 20.3017
SNU-449 GDSC1 5.1993 10.1519 1.3161 9.822
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 174 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L32 GDSC1 1.2888 11.5567 -2.5922 40.1972
DMS 273 GDSC1 1.3518 24.6016 -9.0012 45.2745
EBC-1 GDSC1 1.757 6.4919 0.2986 28.8634
KNS-62 GDSC1 1.7637 11.9441 -2.3479 37.8216
NCI-H3255 GDSC1 2.4792 10.1702 -0.8276 30.5867
NCI-H446 GDSC1 2.5296 6.9276 0.8226 22.1078
CPC-N GDSC1 2.8448 5.3147 1.9045 13.0186
NCI-H661 GDSC1 2.8504 6.044 1.5504 15.6758
HCC827 GDSC1 2.8705 4.6584 2.2482 10.2572
SBC-3 GDSC1 3.108 4.8358 2.3801 8.2402
HCC44 GDSC1 3.1493 4.8804 2.3946 7.9633
RERF-LC-KJ GDSC1 3.1732 4.8095 2.4508 7.4284
SBC-1 GDSC1 3.2961 6.2731 1.8247 11.8548
PC-14 GDSC1 3.3237 6.6452 1.6618 12.9922
BEN GDSC1 3.3325 6.5273 1.7281 12.4585
NCI-H1581 GDSC1 3.4436 9.6043 0.2815 21.6582
NCI-H1299 GDSC1 3.4459 5.1809 2.4936 6.0968
HOP-62 GDSC1 3.457 5.5423 2.3222 7.4069
NCI-H522 GDSC1 3.4897 10.5818 -0.1692 23.8407
COR-L105 GDSC1 3.5175 13.1496 -1.4298 28.9153
LCLC-97TM1 GDSC1 3.5205 6.4461 1.9221 10.3068
LC-1/sq GDSC1 3.5341 5.8804 2.2149 7.9858
NCI-H1666 GDSC1 3.5514 8.333 1.005 16.8462
LK-2 GDSC1 3.5525 12.8144 -1.2336 28.1093
NCI-H1693 GDSC1 3.5929 6.9435 1.7317 11.5104
NCI-H292 GDSC1 3.6132 10.2854 0.0799 22.1364
NCI-H2347 GDSC1 3.6144 9.8774 0.2846 21.0244
NCI-H2595 GDSC1 3.6223 6.9917 1.731 11.4157
LOU-NH91 GDSC1 3.6465 6.9814 1.7552 11.1513
NCI-H647 GDSC1 3.6532 6.5653 1.9673 9.5115
NCI-H1944 GDSC1 3.6617 6.5762 1.9685 9.4742
NCI-H2722 GDSC1 3.6989 8.1625 1.2082 14.947
NCI-H526 GDSC1 3.7282 6.9322 1.8432 10.2148
NCI-H810 GDSC1 3.7335 6.4014 2.1103 8.1504
NCI-H1703 GDSC1 3.7337 7.6015 1.5149 12.6445
VMRC-LCD GDSC1 3.7447 5.8801 2.3758 6.0612
IA-LM GDSC1 3.7503 7.2365 1.7092 11.152
NCI-H1355 GDSC1 3.7522 7.3454 1.6566 11.5387
DMS 114 GDSC1 3.7534 6.0293 2.3088 6.5529
HOP-92 GDSC1 3.7671 7.8214 1.4316 13.1362
COR-L279 GDSC1 3.7716 7.644 1.5233 12.4569
Calu-3 GDSC1 3.774 6.3911 2.1459 7.7488
EMC-BAC-2 GDSC1 3.7764 9.8901 0.4085 19.7557
NCI-H290 GDSC1 3.7797 6.1836 2.2524 6.9092
NCI-H847 GDSC1 3.7837 6.6971 2.002 8.8245
UMC-11 GDSC1 3.7952 6.6488 2.0345 8.539
NCI-H2444 GDSC1 3.8169 6.0827 2.3292 6.2056
NCI-H2803 GDSC1 3.8597 6.139 2.3325 6.0545
NCI-H2591 GDSC1 3.8757 9.3596 0.7513 17.3579
NCI-H23 GDSC1 3.8826 6.3529 2.2445 6.6627
IST-SL1 GDSC1 3.8982 8.7498 1.072 15.2022
NCI-H1436 GDSC1 3.9233 6.1164 2.3886 5.4446
LXF 289 GDSC1 3.9269 7.5604 1.6834 10.7773
NCI-H2172 GDSC1 3.9315 5.6313 2.6272 3.6243
NCI-H838 GDSC1 3.978 6.9776 2.0079 8.1856
NCI-H1869 GDSC1 3.9898 6.129 2.4284 4.9621
DMS 79 GDSC1 3.9898 9.2263 0.9062 15.9924
A-549 GDSC1 3.9928 6.9804 2.0172 8.0716
COR-L23 GDSC1 4.0036 8.4309 1.3109 13.2196
SBC-5 GDSC1 4.0084 5.2381 2.8574 1.7991
NCI-H2029 GDSC1 4.0464 6.3258 2.3724 5.2326
NCI-H69 GDSC1 4.0658 8.3652 1.3902 12.4651
NCI-H720 GDSC1 4.0744 6.6354 2.2426 6.1343
HARA [Human squamous cell lung carcinoma] GDSC1 4.0775 6.3413 2.386 5.0487
NCI-H460 GDSC1 4.0906 7.7073 1.7322 9.9135
SK-MES-1 GDSC1 4.0918 7.5654 1.8026 9.3887
NCI-H1341 GDSC1 4.1021 7.7566 1.7164 9.9957
COR-L88 GDSC1 4.1183 10.7804 0.2338 19.5912
NCI-H2369 GDSC1 4.1199 6.7609 2.2135 6.23
NCI-H226 GDSC1 4.1516 6.1948 2.5041 3.9907
NCI-H727 GDSC1 4.1644 6.3421 2.443 4.4069
NCI-H1435 GDSC1 4.165 7.2601 2.0036 7.6792
NCI-H1650 GDSC1 4.1704 11.5873 -0.1267 21.3149
NCI-H2795 GDSC1 4.1719 6.4175 2.4123 4.6143
RERF-LC-MS GDSC1 4.2 9.4542 0.9533 15.0108
NCI-H441 GDSC1 4.2082 7.7958 1.7737 9.2619
NCI-H82 GDSC1 4.2107 7.2873 2.0222 7.4135
NCI-H1836 GDSC1 4.2164 9.6828 0.8527 15.6063
NCI-H211 GDSC1 4.2419 8.1873 1.6068 10.3811
Lu-139 GDSC1 4.2431 6.4616 2.4373 4.2589
NCI-H2731 GDSC1 4.2451 6.3646 2.4839 3.9175
LC-2/ad GDSC1 4.2578 7.0236 2.1809 6.1074
NCI-H596 GDSC1 4.2617 6.2783 2.5342 3.5201
LCLC-103H GDSC1 4.2987 6.2049 2.5902 3.046
EKVX GDSC1 4.31 11.8449 -0.1467 20.9709
Ms-1 GDSC1 4.3357 6.6708 2.3981 4.3263
NCI-H1092 GDSC1 4.3428 7.0667 2.2167 5.6282
NCI-H146 GDSC1 4.3448 7.9381 1.8007 8.6784
NCI-H1975 GDSC1 4.3482 10.1304 0.7305 15.9599
NCI-H1993 GDSC1 4.3566 7.1989 2.1631 5.9863
NCI-H2461 GDSC1 4.3577 7.8304 1.8616 8.1977
NCI-H1648 GDSC1 4.3622 7.6178 1.9669 7.4136
NCI-H2009 GDSC1 4.3638 10.3889 0.6147 16.6171
NCI-H841 GDSC1 4.3682 7.5761 1.9909 7.221
NCI-H187 GDSC1 4.3768 9.0951 1.2603 12.4215
NCI-H2081 GDSC1 4.3876 9.5214 1.0592 13.7399
NCI-H1781 GDSC1 4.3911 6.881 2.3349 4.6525
NCI-H209 GDSC1 4.394 8.4459 1.5891 10.0697
NCI-H1155 GDSC1 4.42 7.6109 2.0091 6.9529
CAL-12T GDSC1 4.4466 11.7919 -0.0161 19.8823
HCC15 GDSC1 4.4546 10.2798 0.7359 15.6009
NCI-H2135 GDSC1 4.4629 7.8345 1.931 7.411
NCI-H345 GDSC1 4.4874 5.8594 2.8426 1.1223
NCI-H2030 GDSC1 4.4993 7.6306 2.052 6.4396
NCI-H2085 GDSC1 4.517 7.6384 2.0599 6.3385
NCI-H1304 GDSC1 4.5206 6.4622 2.6023 2.5314
NCI-H2227 GDSC1 4.5454 9.9527 0.9627 13.8999
NCI-H1048 GDSC1 4.5719 7.452 2.1824 5.3267
ABC-1 GDSC1 4.5882 7.7812 2.0386 6.3178
SW1573 GDSC1 4.5884 7.3673 2.232 4.9363
NCI-H1563 GDSC1 4.593 12.6929 -0.351 21.0942
Calu-6 GDSC1 4.603 7.8457 2.0178 6.4316
NCI-H2023 GDSC1 4.6077 6.6999 2.5459 2.7422
RERF-LC-Sq1 GDSC1 4.6119 10.3366 0.8229 14.5915
NCI-H1755 GDSC1 4.6123 8.4513 1.7366 8.4228
NCI-H1838 GDSC1 4.6228 7.6097 2.1409 5.5048
HCC366 GDSC1 4.632 10.7827 0.619 15.7798
NCI-H358 GDSC1 4.6454 7.0262 2.4219 3.497
EPLC-272H GDSC1 4.6524 22.395 -5.1298 34.3579
NCI-H1105 GDSC1 4.66 8.9969 1.5073 9.9134
Lu-99A GDSC1 4.6607 7.3279 2.2941 4.3424
NCI-H2122 GDSC1 4.6615 6.5199 2.6531 1.9727
NCI-H1793 GDSC1 4.6869 6.9299 2.4884 2.9739
Lu-65 GDSC1 4.7024 9.8945 1.1029 12.5365
COR-L321 GDSC1 4.713 8.0907 1.9732 6.4854
NCI-H513 GDSC1 4.724 9.6921 1.2161 11.7267
NCI-H650 GDSC1 4.7262 6.5489 2.6739 1.7514
NCI-H1792 GDSC1 4.7354 7.1104 2.4356 3.2318
NCI-H196 GDSC1 4.7754 6.6074 2.6741 1.6802
COLO 668 GDSC1 4.7791 7.1717 2.4329 3.1689
NCI-H2373 GDSC1 4.7805 10.6488 0.7914 14.3008
SK-LU-1 GDSC1 4.7852 7.3019 2.3785 3.5168
Lu-135 GDSC1 4.7871 9.0786 1.5541 9.2525
NCI-H1651 GDSC1 4.7945 8.7757 1.703 8.1952
NCI-H2066 GDSC1 4.8117 7.1973 2.4397 3.0649
PaCa-3 GDSC1 4.8635 10.6458 0.8516 13.6931
HCC78 GDSC1 4.8682 12.9549 -0.2745 19.9161
Lu-134-A GDSC1 4.8758 9.9123 1.2145 11.3242
IST-SL2 GDSC1 4.9083 8.3148 1.9911 5.9105
COR-L95 GDSC1 4.9089 7.2474 2.4707 2.6995
NCI-H1694 GDSC1 4.9388 6.9998 2.5916 1.9244
NCI-H2110 GDSC1 4.986 9.7375 1.3725 9.9817
SHP-77 GDSC1 4.9911 12.6679 -0.0435 18.413
ChaGo-K-1 GDSC1 5.0088 7.376 2.4681 2.5536
EMC-BAC-1 GDSC1 5.0149 8.5522 1.9469 5.9809
NCI-H2228 GDSC1 5.0242 10.2536 1.1516 11.3448
LB647-SCLC GDSC1 5.0679 7.2546 2.5495 1.9844
NCI-H1623 GDSC1 5.0819 7.6188 2.4023 2.8403
NCI-H322M GDSC1 5.0847 7.9826 2.2449 3.8363
NCI-H835 GDSC1 5.0987 7.8327 2.3185 3.3373
NCI-H2342 GDSC1 5.1217 10.6396 1.0326 11.856
NCI-H2291 GDSC1 5.1298 7.6585 2.4104 2.714
NCI-H2810 GDSC1 5.1356 7.3932 2.5253 2.0284
NCI-H2818 GDSC1 5.1379 6.8499 2.7449 0.9036
NCI-H2170 GDSC1 5.1534 11.1146 0.8261 13.0631
Lu-165 GDSC1 5.1649 12.1853 0.3164 16.0097
NCI-H524 GDSC1 5.2277 7.2677 2.6206 1.4017
NCI-H520 GDSC1 5.2348 7.5261 2.5189 1.9308
SW1271 GDSC1 5.4248 7.3461 2.6773 0.9444
NCI-H1573 GDSC1 5.4344 7.2258 2.7268 0.7364
NCI-H2405 GDSC1 5.4368 8.3555 2.2725 3.0674
NCI-H2141 GDSC1 5.4557 7.4194 2.6623 0.9816
NCI-H3122 GDSC1 5.4657 7.6236 2.5873 1.3108
NCI-H1770 GDSC1 5.6704 15.3374 -0.8589 20.3783
A-427 GDSC1 5.6881 8.0784 2.5078 1.4621
NCI-H1915 GDSC1 5.7854 7.5611 2.7428 0.4682
NCI-H1568 GDSC1 5.8152 19.7282 -2.9074 26.9906
NCI-H1688 GDSC1 5.8827 15.6879 -0.8788 19.9239
NCI-H2087 GDSC1 5.9034 8.0703 2.603 0.8681
NCI-H1437 GDSC1 5.94 8.0079 2.6409 0.7067
DMS 53 GDSC1 6.1555 8.4469 2.5652 0.8336
NCI-H2869 GDSC1 6.1772 8.4052 2.5891 0.7366
NCI-H1876 GDSC1 6.2761 8.0813 2.7413 0.278
NCI-H2804 GDSC1 6.3555 8.7951 2.5168 0.8744
⏷ Show the Full List of 174 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.4962 6.7875 1.7321 11.8414
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE21 GDSC1 2.3117 15.5911 -3.6736 38.2791
KYSE-270 GDSC1 3.1125 5.5359 2.0359 10.9156
KYSE-410 GDSC1 3.3764 6.136 1.96 10.5193
TE-11 GDSC1 3.6604 5.8352 2.335 6.6375
T.T GDSC1 3.7238 5.5806 2.5075 5.1057
TE-9 GDSC1 3.8643 13.1292 -1.1373 26.7238
TE-5 GDSC1 4.0203 9.4171 0.835 16.3486
TE-10 GDSC1 4.0562 8.0487 1.5391 11.4301
KYSE-70 GDSC1 4.3701 6.3222 2.5791 2.9759
OE19 GDSC1 4.396 6.2095 2.6445 2.4832
KYSE-520 GDSC1 4.4515 7.1452 2.2497 5.1248
EC-GI-10 GDSC1 4.465 6.8146 2.4113 3.9427
TE-6 GDSC1 4.475 6.7894 2.4289 3.7984
KYSE-510 GDSC1 4.5376 11.1147 0.3865 17.42
TE-15 GDSC1 4.5639 7.3658 2.2175 5.0948
TE-4 GDSC1 4.5843 11.019 0.468 16.8112
OE33 GDSC1 4.6409 9.2917 1.352 11.0375
TE-1 GDSC1 4.6661 6.9138 2.4839 3.0423
KYSE-180 GDSC1 4.9117 10.9369 0.7442 14.2208
KYSE-140 GDSC1 5.1039 18.171 -2.6749 28.1003
KYSE-150 GDSC1 5.1521 8.5136 2.0461 5.0206
KYSE-450 GDSC1 5.5322 29.169 -7.809 36.103
TE-8 GDSC1 5.8336 8.685 2.332 2.1825
COLO 680N GDSC1 5.8772 7.464 2.8109 0.2587
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RMG-I GDSC1 2.6406 5.0799 1.8261 14.5016
OVTOKO GDSC1 3.1385 6.7073 1.4741 15.0872
SK-OV-3 GDSC1 3.2511 5.9045 1.9711 10.8916
OC 314 GDSC1 3.3046 5.0809 2.428 7.113
TYK-nu GDSC1 3.4117 5.0965 2.5083 6.0988
OAW42 GDSC1 3.4984 6.172 2.0411 9.4617
FU-OV-1 GDSC1 3.5078 9.6956 0.2887 21.3841
OVCAR-8 GDSC1 3.6099 5.159 2.631 4.491
DOV13 GDSC1 3.6466 7.0913 1.7005 11.5625
TOV-112D GDSC1 3.709 14.6431 -2.0194 30.1661
JHOS-4 GDSC1 3.7148 12.5184 -0.9532 26.5056
OVCAR-5 GDSC1 3.7653 5.5251 2.5644 4.5469
OV56 GDSC1 3.8246 5.5641 2.587 4.2085
TOV-21G GDSC1 3.8505 7.0171 1.8942 9.4364
EFO-21 GDSC1 3.8866 7.7946 1.537 11.9811
OVCAR-4 GDSC1 3.9461 8.6422 1.1624 14.4327
ES-2 GDSC1 4.0081 7.4094 1.8181 9.5243
JHOS-2 GDSC1 4.0847 7.5799 1.7903 9.5011
OVK18 GDSC1 4.1414 9.4639 0.9043 15.5135
OVCAR-3 GDSC1 4.3209 6.4262 2.5022 3.6161
Kuramochi GDSC1 4.4746 8.4136 1.6609 9.3314
Caov-4 GDSC1 4.7118 7.1453 2.4066 3.4701
OVISE GDSC1 4.7717 10.541 0.8377 14.0386
OAW28 GDSC1 4.8345 11.1664 0.5776 15.4383
A2780 GDSC1 5.3794 7.0962 2.7528 0.6777
OVKATE GDSC1 5.481 7.3266 2.7082 0.774
OV-90 GDSC1 5.8015 15.6584 -0.9219 20.3096
EFO-27 GDSC1 5.8369 7.6625 2.7261 0.4915
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1 1.5954 37.1027 -15.0279 46.5064
PaTu 8988t GDSC1 3.1575 7.915 0.887 19.0911
BxPC-3 GDSC1 3.312 11.0827 -0.5667 26.3133
HuP-T4 GDSC1 3.3387 5.696 2.1488 9.1839
HPAF-II GDSC1 3.484 8.2152 1.009 17.0613
SU.86.86 GDSC1 3.6416 6.463 2.0092 9.2268
MZ-PC-1 GDSC1 3.6943 8.0992 1.2361 14.7687
DAN-G GDSC1 3.7008 6.562 2.0058 9.06
Panc 04.03 GDSC1 3.77 7.2444 1.7204 11.0039
CFPAC-1 GDSC1 3.8124 6.3664 2.1866 7.3168
KP-4 GDSC1 3.8281 5.6479 2.549 4.488
SUIT-2 GDSC1 3.8745 10.2875 0.2882 20.1011
KP-1N GDSC1 3.9147 7.5254 1.6915 10.7555
Panc 02.03 GDSC1 3.9942 6.9925 2.0123 8.1043
Panc 08.13 GDSC1 4.0066 9.9145 0.5775 17.9847
PL4 GDSC1 4.0186 6.6092 2.2165 6.4857
Panc 10.05 GDSC1 4.1388 9.8714 0.7005 16.8057
QGP-1 GDSC1 4.4395 6.7011 2.448 3.7407
YAPC GDSC1 4.6485 6.5093 2.6508 2.0071
KP-3 GDSC1 4.8581 7.2104 2.4594 2.8569
PaTu 8902 GDSC1 4.9677 6.6151 2.7616 0.9895
HuP-T3 GDSC1 4.9709 6.8627 2.6639 1.4789
SW1990 GDSC1 4.9723 10.0545 1.2118 11.086
Hs 766T GDSC1 5.0374 6.8349 2.7061 1.1847
HPAC GDSC1 5.2897 6.9525 2.7698 0.6777
Capan-2 GDSC1 5.4191 12.642 0.2727 15.5692
Capan-1 GDSC1 5.4275 7.1401 2.7559 0.6328
AsPC-1 GDSC1 5.4907 12.395 0.4408 14.4503
PSN1 GDSC1 5.5548 14.2982 -0.435 18.7922
Panc 03.27 GDSC1 5.5807 13.2826 0.0752 16.2031
KP-2 GDSC1 6.5945 16.0743 -0.5764 16.9008
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 3.0129 4.9171 2.2541 9.6103
NCI-H28 GDSC1 3.683 6.4049 2.07 8.6224
NCI-H2452 GDSC1 4.2793 9.1105 1.1816 13.2501
MPP 89 GDSC1 4.8103 8.06 2.0485 5.73
MSTO-211H GDSC1 5.8501 7.8038 2.6801 0.629
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 2.6619 6.6154 1.0973 19.7142
VCaP GDSC1 3.7915 7.6292 1.546 12.2245
DU145 GDSC1 4.0264 11.0299 0.0382 20.9415
PC-3 GDSC1 4.0844 9.2654 0.9592 15.3403
22Rv1 GDSC1 4.3986 9.2249 1.2125 12.6819
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.4735 6.5161 2.5518 2.9559
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-4 GDSC1 1.8451 8.9313 -0.7919 33.2114
UACC-62 GDSC1 2.8973 9.4478 -0.1016 25.7524
CHL-1 GDSC1 3.2331 7.8715 0.9727 18.2371
G-mel GDSC1 3.2666 7.0033 1.4349 14.8854
IPC-298 GDSC1 3.3774 5.7156 2.171 8.8707
G-361 GDSC1 3.4075 6.1558 1.9756 10.2879
A-375 GDSC1 3.6287 6.4443 2.0084 9.2759
GAK GDSC1 3.6586 6.597 1.9558 9.582
SK-MEL-5 GDSC1 3.7036 11.5189 -0.463 24.4718
IGR-37 GDSC1 3.7043 6.2254 2.1752 7.7401
A2058 GDSC1 3.7138 6.7996 1.8979 9.8444
LOX-IMVI GDSC1 3.7442 5.8354 2.3974 5.8959
COLO 800 GDSC1 3.7445 5.9414 2.3455 6.2962
A101D GDSC1 3.7684 7.4298 1.6272 11.7032
COLO 792 GDSC1 3.8343 6.7761 2.001 8.6737
SK-MEL-28 GDSC1 3.8419 6.0363 2.3699 5.8195
CP66-MEL GDSC1 3.907 7.3815 1.7567 10.2939
451Lu GDSC1 3.9176 6.1313 2.3774 5.5467
SK-MEL-30 GDSC1 3.9278 7.7426 1.594 11.4323
SK-MEL-2 GDSC1 3.9555 5.8354 2.5459 4.1696
Hs 938.T GDSC1 4.0305 5.8276 2.5989 3.5886
Mel Ho GDSC1 4.0406 8.3808 1.3636 12.7324
COLO 783 GDSC1 4.0406 6.0447 2.5028 4.2732
LB373-MEL-D GDSC1 4.1163 7.3259 1.9372 8.3137
WM793 GDSC1 4.1343 6.605 2.2981 5.5572
HMV-II GDSC1 4.1588 7.3536 1.9538 8.0681
UACC-257 GDSC1 4.1597 11.4039 -0.0439 20.9303
DJM-1 GDSC1 4.1722 7.8735 1.71 9.8345
WT2-iPS GDSC1 4.1889 6.9601 2.1649 6.4083
MeWo GDSC1 4.2021 7.3262 1.9974 7.6216
SK-MEL-31 GDSC1 4.2435 7.0412 2.1629 6.2783
SK-MEL-1 GDSC1 4.245 6.456 2.4412 4.2264
IST-MEL1 GDSC1 4.2482 7.5258 1.9329 7.9732
HT-144 GDSC1 4.3105 6.2689 2.5681 3.1756
IGR-1 GDSC1 4.3155 6.6551 2.3927 4.4118
COLO 679 GDSC1 4.3519 14.1065 -1.2378 25.5782
MMAc-SF GDSC1 4.3594 10.4162 0.5979 16.7317
RPMI-7951 GDSC1 4.4003 6.4616 2.5337 3.2268
WM1552C GDSC1 4.4234 6.4156 2.568 2.9447
M14 GDSC1 4.4472 6.4187 2.5803 2.8151
CP50-MEL-B GDSC1 4.4783 8.7529 1.4994 10.4684
RVH-421 GDSC1 4.5066 10.6413 0.5965 16.2893
WM115 GDSC1 4.5319 7.763 2.0107 6.6571
MZ-MEL-7 GDSC1 4.5416 6.2711 2.6969 1.8948
A-431 GDSC1 4.6478 7.6513 2.1372 5.4736
Hs 940.T GDSC1 4.6579 7.2142 2.3442 4.002
COLO 829 GDSC1 4.7235 8.3949 1.8368 7.4281
MZ-MEL-2 GDSC1 4.7654 9.6937 1.244 11.4261
A-388 GDSC1 4.7715 7.0315 2.4904 2.8092
LB2518-MEL GDSC1 4.7979 6.127 2.8768 0.632
WM278 GDSC1 4.8019 7.3298 2.3756 3.5045
VMRC-MELG GDSC1 5.1743 6.802 2.7787 0.7302
SK-MEL-3 GDSC1 5.3206 7.2365 2.6745 1.0492
WM35 GDSC1 5.653 19.5189 -2.9254 27.4233
SK-MEL-24 GDSC1 5.9792 15.5494 -0.7439 19.1046
Mel JuSo GDSC1 6.356 17.2037 -1.2819 20.4088
EquiPSC Line K2 GDSC1 4.0789 6.6533 2.2371 6.1637
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 5.8897 7.588 2.7724 0.3424
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC1 2.2824 3.77 2.0398 14.6452
VA-ES-BJ GDSC1 2.3453 8.2331 0.0115 27.5226
G-401 GDSC1 2.776 6.3126 1.3504 17.451
SW872 GDSC1 3.0695 6.2844 1.6254 14.2315
A-204 GDSC1 3.2568 6.8537 1.5015 14.4346
SW982 GDSC1 3.3977 5.9205 2.0852 9.4701
HT-1080 GDSC1 3.5842 5.2832 2.5504 5.1982
GCT GDSC1 3.6081 5.5608 2.4311 6.0543
MFH-ino GDSC1 3.6089 6.7136 1.859 10.4896
SK-UT-1 GDSC1 3.6496 6.4951 1.9995 9.2756
Hs 633.T GDSC1 3.7082 7.4705 1.5601 12.3982
Rh41 GDSC1 3.8787 5.6855 2.5658 4.2222
SK-LMS-1 GDSC1 3.9633 8.3675 1.3117 13.3438
G-402 GDSC1 3.984 7.7862 1.6147 11.1044
MES-SA GDSC1 4.035 7.3564 1.8637 9.1024
RKN GDSC1 4.1728 6.1356 2.5452 3.6424
EW-8 GDSC1 4.2064 6.9647 2.1745 6.2897
Rh30 GDSC1 4.2506 8.9937 1.2179 13.0911
STS-0421 GDSC1 4.3346 8.8186 1.365 11.8239
SW684 GDSC1 4.7115 6.058 2.8662 0.755
Rh18 GDSC1 5.1627 12.1754 0.3197 15.9977
RD GDSC1 5.4212 12.6804 0.2557 15.6564
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 GDSC1 3.0552 7.7137 0.9 19.408
HGC-27 GDSC1 3.3134 7.1411 1.4052 14.9264
Hs 746.T GDSC1 3.4731 6.1909 2.0114 9.7794
MKN28 GDSC1 3.4806 7.1991 1.5139 13.5253
MKN45 GDSC1 3.7006 8.9876 0.7981 17.6643
AGS GDSC1 3.8259 6.9418 1.9129 9.3714
SNU-16 GDSC1 3.8743 7.7684 1.5406 11.9943
MKN1 GDSC1 3.8784 6.3689 2.2336 6.7579
SK-GT-2 GDSC1 3.9679 6.6338 2.1686 6.9943
OCUM-1 GDSC1 3.9729 9.2877 0.8627 16.3278
HSC-39 GDSC1 3.976 6.6342 2.1742 6.9281
23132/87 GDSC1 4.0421 6.6072 2.2339 6.289
SCH GDSC1 4.0815 7.7922 1.6839 10.2972
RERF-GC-1B GDSC1 4.1057 7.3482 1.9187 8.4826
ECC10 GDSC1 4.2279 8.9593 1.218 13.1595
NCI-N87 GDSC1 4.282 9.077 1.2 13.1169
NUGC-4 GDSC1 4.4824 6.9635 2.3534 4.3134
TGBC11TKB GDSC1 4.6003 9.6685 1.1407 12.5766
NUGC-3 GDSC1 4.6029 13.9949 -0.9882 23.8572
SNU-1 GDSC1 4.8934 12.813 -0.1861 19.4103
SNU-5 GDSC1 5.0751 6.8839 2.7038 1.1557
MKN7 GDSC1 5.113 8.276 2.1304 4.5363
RF-48 GDSC1 5.1275 8.3299 2.1145 4.6134
KATO III GDSC1 5.6854 8.0485 2.5183 1.4151
IM95 GDSC1 6.0424 8.0266 2.6741 0.5416
TMK-1 GDSC1 6.1882 7.9656 2.7496 0.2882
SNG-M GDSC1 3.1039 7.3867 1.105 17.8442
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC1 2.4214 5.6082 1.3628 18.9192
HTC-C3 GDSC1 2.7405 6.473 1.239 18.3936
CAL-62 GDSC1 3.1617 6.73 1.4826 14.9354
KMH-2 GDSC1 3.8977 6.0922 2.3823 5.5646
IHH-4 GDSC1 3.9604 6.8798 2.043 7.9712
WRO GDSC1 4.1 6.5387 2.3066 5.5843
8305C GDSC1 4.3199 9.1616 1.1863 13.0952
B-CPAP GDSC1 4.3446 9.8628 0.8597 15.1622
K5 GDSC1 4.3837 8.6672 1.4742 10.9153
TT GDSC1 4.5539 9.7393 1.073 13.1574
ML-1 [Human leukemia] GDSC1 4.7089 6.9506 2.4915 2.9139
CGTH-W-1 GDSC1 4.9338 6.655 2.7305 1.177
ASH-3 GDSC1 5.2139 7.7609 2.4103 2.5846
8505C GDSC1 5.2556 7.5592 2.5154 1.923
TT2609-C02 GDSC1 5.625 8.2964 2.391 2.1264
FTC-133 GDSC1 6.3316 16.8838 -1.1441 19.9231
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-3 GDSC1 1.5446 6.5693 0.0536 31.2063
BICR 78 GDSC1 2.1115 9.4084 -0.7808 31.9717
CAL-27 GDSC1 2.3367 10.9756 -1.3541 32.9786
JHU-029 GDSC1 2.7265 6.1884 1.3666 17.544
HO-1-N-1 GDSC1 2.7686 6.6522 1.1759 18.717
SAT [Human HNSCC] GDSC1 3.0692 6.8283 1.3539 16.2316
HSC-4 GDSC1 3.0921 7.7529 0.9121 19.1831
BB49-HNC GDSC1 3.1455 10.0709 -0.2007 25.2658
Ca9-22 GDSC1 3.1502 5.8597 1.9073 11.7677
JHU-011 GDSC1 3.1957 18.3444 -4.2948 36.6565
SAS GDSC1 3.2324 6.0691 1.8731 11.7199
SCC-15 GDSC1 3.244 14.4825 -2.3234 32.4866
PCI-04B GDSC1 3.2567 7.7269 1.0648 17.529
PCI-38 GDSC1 3.2609 5.2574 2.3028 8.2592
BB30-HNC GDSC1 3.2828 9.2132 0.3436 21.9089
DOK GDSC1 3.3558 5.3187 2.3516 7.5294
KOSC-2 GDSC1 3.3736 5.2408 2.4052 7.044
KON GDSC1 3.4117 5.2042 2.4545 6.5218
NCI-H3118 GDSC1 3.476 5.3184 2.449 6.3458
SKN-3 GDSC1 3.5112 9.7753 0.2516 21.577
Detroit 562 GDSC1 3.5135 8.3394 0.971 17.2075
JHU-022 GDSC1 3.5503 7.3962 1.4718 13.5867
OSC-19 GDSC1 3.7341 12.2748 -0.8158 25.8882
OSC-20 GDSC1 3.8019 5.9577 2.3795 5.8627
FaDu GDSC1 3.8086 6.6754 2.0315 8.5206
LB771-HNC GDSC1 3.8802 6.4052 2.2172 6.8789
BICR 10 GDSC1 3.9173 7.5349 1.6887 10.7683
BHY GDSC1 3.9869 6.8932 2.0556 7.7974
HO-1-u-1 GDSC1 4.0637 7.9561 1.5903 11.0356
HSC-2 GDSC1 4.086 12.471 -0.6324 23.9548
SCC-4 GDSC1 4.1696 8.5463 1.3781 12.2284
BICR 22 GDSC1 4.3996 14.5739 -1.4331 26.1514
SCC-25 GDSC1 4.4116 10.3537 0.6677 16.1496
PE/CA-PJ15 GDSC1 4.5839 9.5769 1.1736 12.4045
PCI-06A GDSC1 4.585 10.3256 0.8089 14.7584
PCI-30 GDSC1 4.5943 7.6718 2.0939 5.9068
UPCI-SCC-090 GDSC1 4.8345 7.5309 2.3043 3.9182
SCC-9 GDSC1 5.0524 7.1264 2.595 1.7497
CAL-33 GDSC1 5.4193 7.1335 2.7551 0.6416
PCI-15A GDSC1 5.8851 7.497 2.8024 0.2744
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1 2.1036 9.4191 -0.7933 32.0523
KU-19-19 GDSC1 2.7041 6.1692 1.3555 17.7193
CAL-29 GDSC1 2.8704 11.9846 -1.3912 31.051
SW780 GDSC1 3.5471 6.1909 2.0705 9.0675
SW1710 GDSC1 3.656 6.77 1.8678 10.2651
639V GDSC1 3.8206 14.5913 -1.9028 29.4687
5637 GDSC1 4.2991 6.2926 2.5504 3.3237
RT-112 GDSC1 4.5468 15.1641 -1.6119 26.3473
J82 GDSC1 4.5689 8.7183 1.5789 9.6572
RT-4 GDSC1 4.5866 10.6819 0.6354 15.8164
HT-1197 GDSC1 4.6685 9.4536 1.2929 11.3637
UM-UC-3 GDSC1 5.3787 7.0669 2.7634 0.6387
HT-1376 GDSC1 5.3893 16.2272 -1.4992 23.63
T24 GDSC1 6.3944 8.4709 2.6487 0.4488
TCCSUP GDSC1 7.4465 23.0062 -3.3307 24.5927
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -0.0014 5.6056 -1.1095 44.4795
BPH-1 GDSC1 1.4894 9.6787 -1.4884 36.9915
TC-YIK GDSC1 2.0356 5.16 1.1923 21.9623
HT-3 GDSC1 2.2897 5.3148 1.3738 19.4534
OVCA420 GDSC1 2.4971 8.2575 0.137 26.2172
C-33 A GDSC1 2.6342 8.0721 0.3519 24.4677
Ca Ski GDSC1 2.7119 5.7644 1.5613 16.1805
SW962 GDSC1 3.0264 6.6732 1.394 16.111
OVMIU GDSC1 3.1853 5.9723 1.8812 11.8353
SiSo GDSC1 3.1967 10.0777 -0.1608 24.8788
CAL-39 GDSC1 3.3665 5.7101 2.1648 8.9587
OV17R GDSC1 3.377 22.1769 -6.0598 38.5652
HEC-1 GDSC1 3.4552 5.8011 2.1916 8.4368
SiHa GDSC1 3.5022 8.4934 0.8848 17.813
NEC8 GDSC1 3.5422 5.1643 2.5773 5.1214
MS751 GDSC1 3.576 6.642 1.8686 10.5271
SW954 GDSC1 3.5936 8.5098 0.9508 17.0546
HeLa GDSC1 3.7548 6.0128 2.318 6.4775
ME-180 GDSC1 3.8907 11.9923 -0.5488 24.2249
DSH1 GDSC1 3.9078 6.377 2.2509 6.5398
KGN GDSC1 4.1605 9.3821 0.9591 15.0977
SW756 GDSC1 4.1713 6.2979 2.4683 4.205
PEO1 GDSC1 4.172 7.3219 1.9784 7.8473
JHOS-3 GDSC1 4.1838 6.6026 2.3323 5.176
OVCA433 GDSC1 4.1979 7.252 2.0304 7.3878
JAR GDSC1 4.2562 7.7917 1.8097 8.8607
OMC-1 [Human cervical carcinoma] GDSC1 4.2716 6.6286 2.3772 4.6289
DoTc2 4510 GDSC1 4.5183 6.5669 2.5547 2.8506
HEY GDSC1 4.525 7.432 2.1621 5.5819
LB831-BLC GDSC1 4.5764 6.9693 2.4073 3.7355
SKN GDSC1 4.6572 11.6969 0.1884 18.1612
UWB1.289 GDSC1 4.6618 9.0316 1.4918 10.0163
PWR-1E GDSC1 5.0054 6.9313 2.6524 1.4979
C-4-I GDSC1 5.1569 7.1479 2.6359 1.4041
SKG-IIIa GDSC1 5.2989 13.7175 -0.3345 18.9993
JEG-3 GDSC1 5.3672 16.8357 -1.8154 24.7973
ACC-OV7 GDSC1 6.3231 19.0803 -2.2177 23.7803
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT01351688) An Open Label Prostate Cancer Study in Japanese Patients. U.S. National Institutes of Health.
2 AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27.