Details of the Drug

General Information of Drug (ID: DMC28Y4)

Drug Name
EAA-090
Synonyms Perzinfotel; EAA 090; Way 126090; WAY-126090; Perzinfotel (USAN/INN); 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-6-yl)ethylphosphonic acid
Indication
Disease Entry ICD 11 Status REF
Diabetic neuropathy 8C0Z Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 260.18
Logarithm of the Partition Coefficient (xlogp) -1.6
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C9H13N2O5P
IUPAC Name
2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethylphosphonic acid
Canonical SMILES
C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
InChI
InChI=1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
InChIKey
BDABGOLMYNHHTR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
6918236
CAS Number
144912-63-0
UNII
FX5AUU7Z8T
DrugBank ID
DB12365
TTD ID
D0N4YX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.