Details of the Drug

General Information of Drug (ID: DMC48D9)

Drug Name
NG-25
Synonyms NG25
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 537.6
Logarithm of the Partition Coefficient (xlogp) 4.9
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C29H30F3N5O2
IUPAC Name
N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
Canonical SMILES
CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
InChI
InChI=1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
InChIKey
SMPGEBOIKULBCT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
53340664
CAS Number
1315355-93-1
TTD ID
D0X7IC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MEK kinase kinase 2 (MAP4K2) TTQFRP0 M4K2_HUMAN Inhibitor [1]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
TGF-beta-activated kinase 1 (MAP3K7) TTJQT60 M3K7_HUMAN Inhibitor [1]
Tyrosine-protein kinase CSK (CSK) TTX6F0Q CSK_HUMAN Inhibitor [1]
Tyrosine-protein kinase Lyn (JTK8) TT1RWNJ LYN_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Src (SRC) DTT SRC 8.62E-01 -0.17 -0.45
Tyrosine-protein kinase Lyn (JTK8) DTT LYN 1.70E-02 -0.22 -0.22
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.3061 5.7391 1.2065 20.9556
EW-13 GDSC1 -1.4764 5.6007 -2.6645 55.72
EW-7 GDSC1 1.003 3.7679 0.6649 31.4927
H-EMC-SS GDSC1 1.0397 6.2729 -0.3016 35.8841
ES8 GDSC1 1.5994 6.4714 0.1696 30.6998
SK-PN-DW GDSC1 1.6021 3.5928 1.3724 23.4403
NOS-1 [Human HNSCC] GDSC1 1.9067 12.4766 -2.462 37.7023
TC-71 GDSC1 1.9148 5.2977 1.0234 24.1136
ES7 GDSC1 1.9337 9.6162 -1.0262 33.8832
MHH-ES-1 GDSC1 2.0278 11.1369 -1.69 35.3547
CADO-ES1 GDSC1 2.2428 3.8662 1.9717 15.7648
ES4 GDSC1 2.2501 8.1717 -0.0259 28.4549
EW-1 GDSC1 2.277 8.4264 -0.1262 28.8067
EW-3 GDSC1 2.6182 10.4722 -0.8342 30.3156
ES6 GDSC1 2.6276 4.6289 2.0436 13.3282
ES1 GDSC1 2.6932 3.9903 2.3973 10.3654
CHSA0108 GDSC1 2.7317 4.871 2.0313 12.948
ES5 GDSC1 2.7904 10.4394 -0.6674 28.9813
EW-11 GDSC1 2.7966 10.2478 -0.5664 28.5439
SJSA-1 GDSC1 3.1105 4.5869 2.5258 7.4962
A-673 GDSC1 3.1943 4.2301 2.7779 5.1827
EW-16 GDSC1 3.3987 7.4306 1.3543 15.3499
SK-ES-1 GDSC1 3.4151 9.411 0.3777 21.5424
CHSA8926 GDSC1 3.6435 5.0947 2.7132 4.1205
HOS GDSC1 3.6444 4.845 2.8361 3.1676
EW-18 GDSC1 3.8692 18.7584 -3.9218 34.3458
CAL-78 GDSC1 4.1012 7.7887 1.726 10.283
EW-24 GDSC1 4.4178 6.2504 2.6687 2.5627
NY GDSC1 4.5006 6.803 2.4673 3.7869
HuO9 GDSC1 4.5332 6.8608 2.4604 3.766
CHSA0011 GDSC1 4.8069 10.1271 1.0902 12.6456
G-292 clone A141B1 GDSC1 5.0598 8.5455 2.0063 5.785
MG-63 GDSC1 5.4266 7.2147 2.7607 0.7691
CAL-72 GDSC1 5.6002 7.068 2.8816 0.2854
U2OS GDSC1 5.6196 7.4435 2.754 0.6576
SaOS-2 GDSC1 6.1185 7.5726 2.8924 0.1263
HuO-3N1 GDSC1 6.2604 9.1732 2.3651 1.7522
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 145 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.3375 10.1023 -0.8994 31.7055
K-562 GDSC1 -7.7416 7.0959 -9.949 73.5694
MY-M12 GDSC1 -7.5738 1.9573 -8.2212 81.8901
EM-2 GDSC1 -7.186 0.7652 -7.5591 84.1916
KCL-22 GDSC1 -6.8317 -2.0569 -6.8714 91.789
JURL-MK1 GDSC1 -6.8013 -5.078 -6.8013 99.3929
ALL-SIL GDSC1 -6.7757 5.0684 -8.2119 74.8828
EoL-1 GDSC1 -6.6489 -5.0792 -6.6489 99.4536
LAMA-84 GDSC1 -6.637 -3.6777 -6.6387 96.5567
MEG-01 GDSC1 -6.4817 -3.1926 -6.4859 95.2186
BV-173 GDSC1 -6.4503 -2.7196 -6.4609 93.7735
GDM-1 GDSC1 -5.8125 0.9754 -6.1149 81.7867
SUP-B15 GDSC1 -5.4024 7.0257 -7.4063 69.2019
MOLM-13 GDSC1 -5.096 -1.6454 -5.1104 89.1066
Ku812 GDSC1 -4.5342 -2.3835 -4.5349 90.8184
RL GDSC1 -4.4962 7.1154 -6.4693 66.7589
NKM-1 GDSC1 -4.4474 -2.4427 -4.4477 90.8033
Mono-Mac-6 GDSC1 -3.9114 0.872 -4.0607 77.1256
NU-DUL-1 GDSC1 -3.0536 -1.0612 -3.0552 78.3218
CTV-1 GDSC1 -3.0188 -1.5887 -3.0189 79.0438
RPMI-6666 GDSC1 -2.8457 5.4688 -4.0874 63.0466
Karpas-620 GDSC1 -2.784 0.9745 -2.876 71.1221
ALL-PO GDSC1 -2.6991 1.7605 -2.8948 68.7058
SU-DHL-5 GDSC1 -2.6607 1.1367 -2.7639 69.9096
SU-DHL-16 GDSC1 -2.5792 -1.4217 -2.5792 74.0625
BE-13 GDSC1 -2.4046 5.9853 -3.8033 60.33
MLMA GDSC1 -2.1228 2.6985 -2.4573 63.1047
EB2 GDSC1 -1.6975 5.0853 -2.7121 57.4616
P30/OHK GDSC1 -1.2872 2.647 -1.5367 56.4611
MV4-11 GDSC1 -1.2361 2.7032 -1.4935 55.9478
CA46 GDSC1 -0.9133 4.739 -1.7426 52.1925
KG-1 GDSC1 -0.9099 2.4269 -1.0827 52.8785
Karpas-45 GDSC1 -0.7513 4.7804 -1.5827 50.8876
SU-DHL-6 GDSC1 -0.6833 0.3259 -0.6834 50.4925
SIG-M5 GDSC1 -0.6581 1.6258 -0.7009 50.1703
Farage GDSC1 -0.5255 1.6969 -0.5682 48.5765
NALM-6 GDSC1 -0.4697 3.9967 -1.0101 48.3571
697 GDSC1 -0.4305 3.8185 -0.9113 47.9324
VL51 GDSC1 -0.4102 1.9804 -0.4764 47.2246
Daudi GDSC1 -0.405 7.0919 -2.1429 48.4269
MHH-PREB-1 GDSC1 -0.3233 3.7807 -0.7828 46.8382
Loucy GDSC1 -0.306 1.191 -0.3123 45.8012
VAL GDSC1 -0.2267 3.8855 -0.7103 45.7336
P32/ISH GDSC1 -0.2252 2.7267 -0.4002 45.2811
Namalwa GDSC1 -0.0736 7.418 -1.9452 46.2467
SU-DHL-4 GDSC1 0.0012 1.1572 -0.0005 41.9465
RPMI-8866 GDSC1 0.007 2.7691 -0.157 42.5388
HAL-01 GDSC1 0.0963 4.7259 -0.651 43.1905
YT GDSC1 0.1034 2.5933 -0.0183 41.2276
ST486 GDSC1 0.252 2.6362 0.1345 39.408
BL-41 GDSC1 0.2809 3.1115 0.0635 39.5081
DND-41 GDSC1 0.3104 4.3016 -0.2667 40.5254
HC-1 GDSC1 0.3731 4.2717 -0.1884 39.7991
MOLP-8 GDSC1 0.5972 5.8637 -0.5777 39.5327
HH [Human lymphoma] GDSC1 0.7389 5.1795 -0.1439 37.1284
Jiyoye GDSC1 0.7828 7.1617 -0.9625 39.4849
ROS-50 GDSC1 0.8173 12.3814 -3.4146 43.4122
RPMI-8402 GDSC1 0.8596 4.586 0.2191 34.7754
PF-382 GDSC1 0.9075 5.4381 -0.0745 35.7801
ARH-77 GDSC1 0.919 5.7866 -0.2113 36.2591
QIMR-WIL GDSC1 1.021 8.2498 -1.2322 38.8746
OCI-Ly19 GDSC1 1.0475 4.1534 0.5814 31.6975
OCI-Ly7 GDSC1 1.0659 3.1801 0.8971 29.2706
U-698-M GDSC1 1.3184 5.6604 0.2545 31.8249
NB4 GDSC1 1.3323 2.4288 1.3153 25.405
OPM-2 GDSC1 1.3526 6.2246 0.0367 32.676
A3/Kawakami GDSC1 1.3748 3.1062 1.2566 25.5282
DB GDSC1 1.4018 3.6808 1.1266 26.2248
AMO1 GDSC1 1.7204 2.6925 1.699 20.5825
SUP-T1 GDSC1 1.7231 5.5273 0.726 26.9893
MC116 GDSC1 1.7833 2.5589 1.7752 19.7116
KMS-11 GDSC1 1.9759 11.6704 -2.0007 36.4223
Ramos.2G6.4C10 GDSC1 2.0188 6.1386 0.7379 25.4022
KOPN-8 GDSC1 2.0342 9.1763 -0.7177 32.3602
Sc-1 GDSC1 2.0379 4.3256 1.5723 19.6892
OCI-AML-5 GDSC1 2.0542 8.7688 -0.4994 31.4299
SU-DHL-8 GDSC1 2.1735 7.605 0.1804 27.7855
WIL2 NS GDSC1 2.1977 3.2659 2.1153 14.9532
JSC-1 GDSC1 2.2759 8.6407 -0.2328 29.2976
JVM-2 GDSC1 2.331 7.3437 0.4546 25.5777
BC-1 GDSC1 2.3353 6.0454 1.0885 21.6247
OCI-AML-3 GDSC1 2.3842 3.6249 2.2116 13.3103
LC4-1 GDSC1 2.3941 9.5486 -0.5743 30.2308
OCI-AML-2 GDSC1 2.4326 3.4465 2.3222 12.2756
CTB-1 GDSC1 2.4449 10.7143 -1.1075 31.9892
TK [Human B-cell lymphoma] GDSC1 2.5088 3.9456 2.2234 12.5686
Hs 445 GDSC1 2.5524 7.5235 0.5699 23.9179
THP-1 GDSC1 2.5888 5.9063 1.3962 18.3247
GR-ST GDSC1 2.5911 6.9124 0.9061 21.6711
SUP-HD1 GDSC1 2.6165 5.38 1.6769 16.1412
MN-60 GDSC1 2.6185 6.8865 0.944 21.3044
HT GDSC1 2.6324 9.5973 -0.3863 28.4431
BALL-1 GDSC1 2.6413 8.7603 0.0374 26.427
Reh GDSC1 2.6482 9.3432 -0.246 27.7522
CCRF-CEM GDSC1 2.6542 3.7822 2.4428 10.2303
KM-H2 GDSC1 2.6628 7.3025 0.7791 22.1666
SR GDSC1 2.6635 3.8859 2.4104 10.418
H9 GDSC1 2.6661 3.486 2.564 9.3075
CESS GDSC1 2.6723 3.9608 2.3883 10.5359
BC-3 GDSC1 2.6874 5.3735 1.7474 15.2989
DEL GDSC1 2.6888 3.107 2.6777 8.4116
KE-37 GDSC1 2.7235 3.3581 2.6652 8.2909
JJN-3 GDSC1 2.7249 3.3179 2.6773 8.2008
DG-75 GDSC1 2.7309 3.5384 2.6166 8.5856
WSU-NHL GDSC1 2.7311 3.7694 2.5293 9.2077
KMS-12-BM GDSC1 2.7336 3.3566 2.6766 8.1564
Karpas-299 GDSC1 2.7456 3.3471 2.6923 7.9815
LP-1 GDSC1 2.758 9.5653 -0.2599 27.3634
TUR GDSC1 2.7672 4.2236 2.3693 10.2161
L-363 GDSC1 2.7773 3.252 2.7495 7.4145
RS4;11 GDSC1 2.7777 3.8551 2.5427 8.8734
MOLT-4 GDSC1 2.7804 8.138 0.4699 23.5198
EJM GDSC1 2.7857 3.4391 2.7091 7.6396
MOLT-13 GDSC1 2.8143 3.5993 2.6843 7.6589
Granta-519 GDSC1 2.8176 4.9824 2.0599 12.2978
KMOE-2 GDSC1 2.8316 3.5227 2.7309 7.2365
PL-21 GDSC1 2.8327 4.4529 2.3277 10.2295
SCC-3 GDSC1 2.8427 3.2601 2.8188 6.5722
SU-DHL-1 GDSC1 2.8666 3.215 2.8528 6.2073
ATN-1 GDSC1 2.9025 3.9477 2.6307 7.6085
SUP-M2 GDSC1 2.9363 3.3815 2.8908 5.548
L-540 GDSC1 3.0595 7.633 0.9657 19.32
Karpas-422 GDSC1 3.0894 4.0348 2.7751 5.6494
A4/Fukuda GDSC1 3.1151 7.589 1.0356 18.6362
ME1 GDSC1 3.2208 4.3393 2.7477 5.3123
U266B1 GDSC1 3.252 4.1701 2.8594 4.3114
P12-Ichikawa GDSC1 3.2783 4.6955 2.6205 6.09
L-1236 GDSC1 3.2954 4.9754 2.4953 7.0121
WSU-DLCL2 GDSC1 3.3065 4.3086 2.8379 4.2704
JVM-3 GDSC1 3.3538 5.873 2.0957 9.9355
RC-K8 GDSC1 3.3598 5.564 2.2553 8.6642
HL-60 GDSC1 3.5595 4.7665 2.8125 3.6053
RPMI-8226 GDSC1 3.568 5.8946 2.2588 7.9112
SK-MM-2 GDSC1 3.582 9.131 0.6547 19.2422
MOLT-16 GDSC1 3.5906 6.9996 1.7259 11.9373
KY821 GDSC1 3.7136 5.7229 2.4559 5.9046
ML-2 GDSC1 3.7671 5.7232 2.4952 5.4379
Raji GDSC1 3.8693 11.7709 -0.4316 24.038
SU-DHL-10 GDSC1 3.8741 14.7469 -1.9136 29.5461
HEL GDSC1 4.2319 11.6185 -0.0698 21.1135
OCI-M1 GDSC1 4.3245 15.771 -2.0639 28.6545
NOMO-1 GDSC1 4.4849 10.3959 0.727 15.8771
P31/FUJ GDSC1 4.4936 6.029 2.8063 1.5659
L-428 GDSC1 4.5979 6.3745 2.713 1.9708
HDLM-2 GDSC1 6.2784 8.0494 2.7868 0.2649
⏷ Show the Full List of 145 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 -1.6052 10.7789 -5.0093 54.0851
ESO-26 GDSC1 1.518 6.5482 0.0534 31.6935
FLO-1 GDSC1 2.4703 9.5227 -0.4933 29.4926
OACP4 C GDSC1 2.6467 8.6507 0.0966 26.1055
KYAE-1 GDSC1 2.6751 7.7758 0.5559 23.4671
KYSE-50 GDSC1 2.8027 4.0261 2.4942 9.1095
ESO-51 GDSC1 2.836 4.05 2.5173 8.7769
TE-12 GDSC1 3.1436 4.9363 2.3826 8.4835
SK-GT-4 GDSC1 3.2784 4.5601 2.6883 5.5558
KYSE-220 GDSC1 4.007 6.3302 2.3704 5.706
HCE-4 GDSC1 5.6479 7.4575 2.7602 0.6181
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.3273 9.1882 0.416 21.5821
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-YS GDSC1 1.498 5.8905 0.3346 30.4103
IMR-5 GDSC1 1.592 9.0073 -1.0471 35.5179
SiMa GDSC1 1.7414 4.8384 1.0475 24.8607
NB1 GDSC1 1.7599 4.2736 1.2994 23.0659
Kelly GDSC1 1.9184 3.0753 1.8539 18.3876
GI-ME-N GDSC1 1.9424 4.6332 1.3437 21.7959
SJNB-13 GDSC1 1.9456 3.5598 1.7567 18.887
TGW GDSC1 2.0476 4.3299 1.5807 19.497
SJNB-14 GDSC1 2.1049 3.0824 2.0545 15.8963
NB(TU)1 GDSC1 2.2577 4.0262 1.9255 16.0173
GOTO GDSC1 2.279 3.854 2.0151 15.2642
NB69 GDSC1 2.3122 4.9507 1.581 18.1821
SJNB-5 GDSC1 2.5699 3.9628 2.2805 11.8411
SK-N-MC-IXC GDSC1 2.5907 3.2111 2.5554 9.7953
SJNB-10 GDSC1 2.6095 3.7366 2.4131 10.677
CHP-134 GDSC1 2.6138 3.5091 2.4996 10.0427
SJNB-17 GDSC1 2.6364 4.6693 2.0335 13.3643
SJNB-7 GDSC1 2.6603 3.7873 2.4472 10.1669
NH-12 GDSC1 2.6923 3.5397 2.5744 9.0914
MHH-NB-11 GDSC1 2.7746 12.2446 -1.5815 32.2356
LA-N-6 GDSC1 2.8795 9.7349 -0.2387 26.7757
SJNB-12 GDSC1 2.8946 4.0847 2.5605 8.1744
SJNB-6 GDSC1 2.8954 4.0598 2.5727 8.0784
CHP-126 GDSC1 2.8978 3.7237 2.7233 6.9451
SK-N-DZ GDSC1 3.2263 4.7505 2.548 6.8595
SK-N-BE(2)-M17 GDSC1 3.6893 6.2658 2.1688 8.2133
SK-N-AS GDSC1 3.8633 5.5212 2.6615 3.8744
CHP-212 GDSC1 4.0057 6.8865 2.0987 7.7432
SK-N-FI GDSC1 4.0905 6.643 2.2772 6.1814
SK-N-SH GDSC1 4.3556 12.1141 -0.2203 21.4655
KP-N-YN GDSC1 5.9636 7.516 2.8577 0.2177
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.6348 5.1134 1.8222 14.9689
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC1 1.0664 3.2917 0.8746 29.8325
MFM-223 GDSC1 1.685 5.2161 0.8256 26.4778
EFM-19 GDSC1 2.2177 6.9848 0.5234 25.7126
HCC70 GDSC1 2.2423 6.4898 0.786 24.0238
HCC202 GDSC1 2.5015 5.6984 1.414 18.5876
MRK-nu-1 GDSC1 2.5229 4.8011 1.8599 15.1974
OCUB-M GDSC1 2.5397 4.8585 1.8499 15.1945
HCC1395 GDSC1 2.698 7.3294 0.7975 21.8996
T-47D GDSC1 2.7218 3.7149 2.5412 9.1702
HCC1599 GDSC1 2.8191 3.3723 2.7655 7.0658
HCC38 GDSC1 2.8589 5.0438 2.069 12.1013
DU4475 GDSC1 2.8667 3.3326 2.8282 6.37
CAL-120 GDSC1 2.8763 6.6696 1.2843 17.8898
UACC-812 GDSC1 2.9508 5.2974 2.0299 12.0154
UACC-893 GDSC1 2.9619 7.6612 0.8668 20.281
COLO 824 GDSC1 3.0166 4.9153 2.2782 9.8152
BT-20 GDSC1 3.0555 3.6962 2.8985 4.8704
JIMT-1 GDSC1 3.077 4.3281 2.6216 6.8897
MDA-MB-453 GDSC1 3.1281 6.3162 1.682 13.9678
BT-474 GDSC1 3.2464 6.3017 1.791 12.6349
BT-549 GDSC1 3.2991 5.7532 2.1098 10.0267
HCC1187 GDSC1 3.3456 5.4553 2.2977 8.3829
CAL-51 GDSC1 3.3593 4.2495 2.9121 3.491
MDA-MB-436 GDSC1 3.3989 4.6124 2.7633 4.5231
AU565 GDSC1 3.4378 5.4423 2.3803 7.3723
HCC1500 GDSC1 3.5265 5.1772 2.5834 5.5042
HCC1806 GDSC1 3.5648 5.0928 2.655 4.8186
YMB-1-E GDSC1 3.5667 5.7488 2.3305 7.3548
MDA-MB-468 GDSC1 3.6142 5.2112 2.6339 4.8272
CAMA-1 GDSC1 3.6689 5.8602 2.3542 6.8361
CAL-148 GDSC1 3.9078 5.8983 2.5103 4.9172
HCC1937 GDSC1 4.0679 5.7253 2.6992 3.0995
ZR-75-30 GDSC1 4.1656 8.6459 1.3518 12.7216
MDA-MB-157 GDSC1 4.1761 6.5957 2.3582 5.3444
MDA-MB-231 GDSC1 4.1857 6.6816 2.3236 5.5781
MDA-MB-330 GDSC1 4.1934 7.4409 1.9625 8.2577
HCC2157 GDSC1 4.2755 6.0922 2.6572 2.9261
HCC1419 GDSC1 4.4236 7.4912 2.0963 6.6439
BT-483 GDSC1 4.4357 7.3221 2.1846 5.9669
MCF-7 GDSC1 4.7163 6.5961 2.6801 1.9848
MDA-MB-175-VII GDSC1 4.8082 6.4717 2.7777 1.2974
MDA-MB-361 GDSC1 5.0574 9.1257 1.736 7.6482
HCC2218 GDSC1 5.0699 12.8022 -0.0259 18.3192
HCC1428 GDSC1 5.1829 6.778 2.8242 0.7047
CAL-85-1 GDSC1 5.1901 14.7974 -0.9173 22.1337
Hs 578T GDSC1 5.3008 7.377 2.6427 1.4192
HDQ-P1 GDSC1 5.3196 7.2558 2.6991 1.127
MDA-MB-415 GDSC1 5.3377 7.2076 2.7258 0.9892
HCC1569 GDSC1 5.364 11.4262 0.8469 12.6857
HCC1954 GDSC1 5.7094 7.6283 2.7218 0.7137
EFM-192A GDSC1 7.4555 17.2913 -0.5632 15.2066
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC1 1.7935 5.1582 0.9622 25.1417
KS-1 [Human Krukenberg tumour] GDSC1 1.9521 4.3785 1.4604 20.9281
MOG-G-CCM GDSC1 1.9626 4.2503 1.5236 20.4271
SF268 GDSC1 2.0879 6.0544 0.8451 24.3962
GB-1 GDSC1 2.4076 7.7063 0.3476 25.8245
U-251MG GDSC1 2.5288 5.4796 1.5452 17.5107
M059J GDSC1 2.5626 6.6775 0.9952 21.1327
NMC-G1 GDSC1 2.6136 4.7294 1.9829 13.8511
D-423MG GDSC1 2.6412 4.9346 1.9135 14.1899
GI-1 GDSC1 2.7286 10.5178 -0.7602 29.5923
SF539 GDSC1 2.7893 7.8585 0.6168 22.6213
T98G GDSC1 2.8362 4.0751 2.5062 8.8594
D-392MG GDSC1 2.8467 4.7331 2.2077 11.0868
KINGS-1 GDSC1 2.8523 13.7992 -2.291 33.9046
D-336MG GDSC1 2.8648 5.1533 2.0211 12.4448
8-MG-BA GDSC1 2.9167 4.1028 2.5742 7.9674
42-MG-BA GDSC1 2.9344 4.5075 2.3999 9.2218
GaMG GDSC1 2.9518 7.3656 1.0052 19.4931
D-502MG GDSC1 2.964 4.4919 2.4357 8.8163
Daoy GDSC1 3.0011 3.6987 2.8414 5.5601
D-566MG GDSC1 3.0396 6.2762 1.6246 14.6875
CAS-1 GDSC1 3.0442 4.6496 2.434 8.4866
U-87MG ATCC GDSC1 3.0626 3.9219 2.8026 5.5593
KNS-81-FD GDSC1 3.1409 4.9446 2.3762 8.5445
DK-MG GDSC1 3.2329 3.9883 2.9323 3.8181
A-172 GDSC1 3.24 4.562 2.6539 5.9736
Onda 11 GDSC1 3.3829 6.7853 1.6638 13.1423
LN-18 GDSC1 3.425 4.3358 2.9224 3.1793
SF295 GDSC1 3.44 4.519 2.8431 3.7528
YKG-1 GDSC1 3.4457 6.15 2.0332 10.0926
YH-13 GDSC1 3.5387 6.6343 1.8666 11.0503
DBTRG-05MG GDSC1 3.6748 7.4471 1.5698 12.7566
SK-MG-1 GDSC1 3.6883 5.5308 2.5317 5.3928
Hs 683 GDSC1 3.7099 4.9403 2.836 2.9844
SF126 GDSC1 3.7944 5.1545 2.7908 3.0989
KALS-1 GDSC1 3.9077 9.8522 0.5555 18.7654
KNS-42 GDSC1 4.0064 11.6635 -0.2688 22.8234
LNZTA3WT4 GDSC1 4.0084 6.6758 2.2035 6.9707
U-118MG GDSC1 4.0303 6.1445 2.4759 4.8451
MOG-G-UVW GDSC1 4.0622 5.8344 2.6444 3.5116
H4 GDSC1 4.1084 6.5518 2.3335 5.7084
D-542MG GDSC1 4.1148 6.1569 2.5264 4.2516
Becker GDSC1 4.2267 6.5825 2.398 4.9209
D-247MG GDSC1 4.2907 6.3963 2.5264 3.8156
Onda 10 GDSC1 4.4431 7.4651 2.1216 6.4087
SW1783 GDSC1 4.4856 6.7542 2.4806 3.7103
LN-405 GDSC1 4.724 6.7745 2.6073 2.4229
SW1088 GDSC1 4.744 7.1919 2.4342 3.5186
PFSK-1 GDSC1 4.9363 10.3743 1.0607 12.4352
LN-229 GDSC1 5.1152 6.7309 2.8136 0.8042
D-263MG GDSC1 5.1717 6.6245 2.8769 0.5142
D283 Med GDSC1 5.5072 6.7939 2.9428 0.1836
ONS-76 GDSC1 6.0257 15.9825 -0.8943 19.8627
SNB-75 GDSC1 6.5435 8.5194 2.7199 0.3201
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.6125 7.195 -0.1573 32.1478
TGBC1TKB GDSC1 2.8216 3.3364 2.7781 6.966
TGBC24TKB GDSC1 3.4135 5.6251 2.2691 8.3639
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 1.0701 9.6851 -1.8694 40.0532
AN3-CA GDSC1 1.744 2.7708 1.7153 20.3339
KLE GDSC1 2.5978 7.7442 0.502 24.115
EN GDSC1 2.7426 3.1917 2.7233 7.7929
RL95-2 GDSC1 2.7823 3.2878 2.7471 7.4014
MFE-319 GDSC1 3.1552 3.9554 2.8761 4.5826
MFE-296 GDSC1 4.4425 6.7741 2.4453 4.0688
ESS-1 GDSC1 5.4437 6.8989 2.883 0.3453
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1 1.2346 4.893 0.4949 31.0506
A-704 GDSC1 1.44 4.3039 0.9469 27.1708
KTCTL-1M GDSC1 1.5331 3.4086 1.352 23.972
LB1047-RCC GDSC1 1.7248 3.5882 1.5075 21.8309
KTCTL-21 GDSC1 2.2335 5.8021 1.1061 21.9862
HA7-RCC GDSC1 2.3913 5.3151 1.49 18.5461
OS-RC-2 GDSC1 2.4984 4.8195 1.827 15.5586
Caki-1 GDSC1 2.5278 5.1289 1.7112 16.2869
TK-10 GDSC1 2.6919 5.0094 1.9268 13.921
CAL-54 GDSC1 2.7449 12.9643 -1.9663 33.4405
VMRC-RCZ GDSC1 2.7597 5.0347 1.9796 13.2187
769-P GDSC1 2.7693 6.8118 1.1178 19.4949
786-O GDSC1 2.7952 8.425 0.3403 24.1876
KTCTL-26A GDSC1 2.8146 4.1264 2.4612 9.3003
BB65-RCC GDSC1 2.8221 3.9221 2.5599 8.5269
NCC021 GDSC1 2.8465 5.0991 2.0305 12.4515
KTCTL-140 GDSC1 2.8478 4.3475 2.3921 9.6686
RCC10RGB GDSC1 3.097 11.6919 -1.0296 29.208
VMRC-RCW GDSC1 3.2739 4.9067 2.5113 6.9662
KTCTL-195 GDSC1 3.4422 6.0178 2.0963 9.6135
KMRC-1 GDSC1 3.615 4.8158 2.8292 3.307
ACHN GDSC1 3.9964 9.6554 0.7229 17.4571
KMRC-20 GDSC1 4.0329 5.7779 2.6522 3.526
SW156 GDSC1 4.7468 10.4837 0.8743 14.1919
A-498 GDSC1 4.8623 6.5566 2.7689 1.278
BFTC-909 GDSC1 4.8788 7.4543 2.3938 3.53
LB2241-RCC GDSC1 4.9221 8.2604 2.0537 5.7591
LB996-RCC GDSC1 4.9442 8.3565 2.0229 5.9237
SN12C GDSC1 5.1356 7.2027 2.6356 1.652
SW13 GDSC1 5.537 7.0212 2.8747 0.3281
UO-31 GDSC1 6.0477 8.35 2.5904 0.9666
KTCTL-13 GDSC1 6.0899 7.8905 2.7737 0.3581
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1 -1.1124 1.978 -1.2251 54.9991
LS513 GDSC1 2.144 4.0768 1.7849 17.6191
HCT 116 GDSC1 2.484 4.2778 2.057 13.8543
SNU-175 GDSC1 2.51 10.3345 -0.8611 30.8533
LS1034 GDSC1 2.5968 6.7005 1.0155 20.9285
GP5d GDSC1 2.5987 3.5284 2.4768 10.2404
HT-29 GDSC1 2.7027 3.776 2.4966 9.5503
COLO 320HSR GDSC1 2.7093 3.8509 2.473 9.7291
SNU-1040 GDSC1 2.7162 3.9783 2.4263 10.0373
NCI-H747 GDSC1 2.7293 5.7187 1.619 16.0778
SW48 GDSC1 2.7771 4.7437 2.1358 11.896
RKO GDSC1 2.8793 9.6909 -0.2169 26.6751
CCK-81 GDSC1 2.9618 4.8663 2.2516 10.2508
LS411N GDSC1 3.014 3.5677 2.9094 4.9981
COLO205 GDSC1 3.0366 3.8146 2.8263 5.5012
KM12 GDSC1 3.3668 4.6375 2.7243 4.945
LoVo GDSC1 3.4602 4.8171 2.7105 4.7074
COLO 678 GDSC1 3.5022 6.1815 2.0632 9.661
HCC2998 GDSC1 3.5341 5.1282 2.6137 5.2415
SNU-407 GDSC1 3.547 7.6902 1.3461 14.8707
SNU-C2B GDSC1 3.6363 5.3949 2.5598 5.3129
SNU-61 GDSC1 3.7927 5.3833 2.6793 3.9487
SW1417 GDSC1 3.824 5.8374 2.4805 5.3837
SW837 GDSC1 3.9347 5.6647 2.6412 3.8554
SNU-C5 GDSC1 3.969 6.1049 2.4529 5.1843
LS180 GDSC1 3.9771 6.379 2.3257 6.1037
T84 GDSC1 4.009 6.3155 2.3789 5.6363
RCM-1 [Human ESC] GDSC1 4.0413 5.5814 2.7495 2.7982
HCT 15 GDSC1 4.0597 8.3345 1.4262 12.5305
CW-2 GDSC1 4.1234 6.9359 2.1584 6.9569
CL-11 GDSC1 4.1556 6.4982 2.391 5.1532
SW948 GDSC1 4.1976 5.8675 2.7131 2.7011
LS123 GDSC1 4.2654 6.6173 2.4068 4.7605
SNU-C1 GDSC1 4.334 6.3445 2.5769 3.3623
HT115 GDSC1 4.3352 7.1769 2.1872 6.1761
CaR-1 GDSC1 4.357 6.5848 2.4801 3.9954
SNU-81 GDSC1 4.5101 6.5359 2.5939 2.8985
SW626 GDSC1 4.5841 8.381 1.7788 8.5299
C2BBe1 GDSC1 4.7123 6.676 2.6437 2.2052
MDST8 GDSC1 4.9952 15.9212 -1.6182 25.268
HT-55 GDSC1 5.1559 7.064 2.7012 1.2814
SW1116 GDSC1 5.2088 6.739 2.8495 0.5886
SW620 GDSC1 5.4214 7.3069 2.7235 0.9214
SW1463 GDSC1 5.6233 7.3996 2.7717 0.5941
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.6114 7.2103 1.6374 12.5263
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-449 GDSC1 2.0595 4.1411 1.6698 18.882
JHH-4 GDSC1 2.2863 3.1573 2.2363 13.6952
SNU-387 GDSC1 2.3315 3.1292 2.2907 13.0148
Hep 3B2.1-7 GDSC1 2.4021 3.7242 2.1955 13.3273
SNU-475 GDSC1 2.4023 3.5468 2.2575 12.891
SNU-423 GDSC1 2.4477 3.8251 2.2064 13.0078
JHH-2 GDSC1 2.6441 3.473 2.5443 9.5653
JHH-7 GDSC1 2.6622 3.5035 2.554 9.3985
JHH-6 GDSC1 2.702 3.2223 2.6739 8.3578
HLE GDSC1 2.737 4.0053 2.4361 9.8621
SK-HEP-1 GDSC1 2.8042 3.3872 2.745 7.2897
Hep-G2/C3A GDSC1 3.2652 4.011 2.9502 3.5472
Huh-7 GDSC1 3.8782 6.3835 2.2524 6.9786
JHH-1 GDSC1 4.771 7.1204 2.4814 3.1533
SNU-398 GDSC1 5.1444 9.0238 1.8377 6.7519
HuH-1 GDSC1 5.3055 6.5822 2.9433 0.2492
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2731 GDSC1 -0.0082 5.5627 -1.0874 44.7897
NCI-H2110 GDSC1 0.4967 3.9269 0.063 37.9296
NCI-H520 GDSC1 0.8398 4.5495 0.2118 34.938
IST-SL1 GDSC1 1.7112 5.1718 0.872 26.1523
NCI-H292 GDSC1 1.7405 8.8395 -0.8259 34.0978
COR-L105 GDSC1 1.8994 4.8693 1.1976 23.0257
SW1271 GDSC1 1.9586 5.0384 1.1839 22.8149
SBC-3 GDSC1 2.1639 9.269 -0.6445 31.506
NCI-H647 GDSC1 2.1764 4.9463 1.4463 19.8909
EPLC-272H GDSC1 2.1799 4.7795 1.5246 19.3125
NCI-H1688 GDSC1 2.211 6.0039 0.9886 22.8767
NCI-H2196 GDSC1 2.3958 5.893 1.2195 20.4478
NCI-H847 GDSC1 2.4209 3.7392 2.2102 13.1227
Lu-135 GDSC1 2.4539 4.9809 1.7081 16.6519
LCLC-97TM1 GDSC1 2.5553 3.8338 2.3174 11.6482
NCI-H1048 GDSC1 2.5789 7.0816 0.8117 22.3274
LC-2/ad GDSC1 2.5986 9.2902 -0.2636 28.0392
NCI-H2030 GDSC1 2.617 4.7123 1.9943 13.7502
NCI-H2135 GDSC1 2.6291 10.1227 -0.6506 29.5595
HCC44 GDSC1 2.6387 4.1786 2.2592 11.6573
NCI-H510A GDSC1 2.6714 4.5655 2.1164 12.5751
NCI-H211 GDSC1 2.691 3.7763 2.4841 9.7423
NCI-H810 GDSC1 2.6963 3.376 2.6305 8.6813
NCI-H64 GDSC1 2.6989 9.0171 -0.0391 26.5633
Ms-1 GDSC1 2.7111 10.0748 -0.5548 28.8381
NCI-H1876 GDSC1 2.7264 5.835 1.5595 16.5318
SHP-77 GDSC1 2.7333 3.3105 2.6883 8.0786
NCI-H838 GDSC1 2.7591 3.2315 2.7339 7.6253
NCI-H1944 GDSC1 2.7878 4.4291 2.2949 10.6836
CAL-12T GDSC1 2.7885 4.237 2.3846 10.0005
NCI-H1581 GDSC1 2.7908 8.4571 0.3205 24.315
NCI-H3122 GDSC1 2.8051 4.5848 2.2384 11.0358
NCI-H522 GDSC1 2.8101 3.6905 2.6444 7.9675
UMC-11 GDSC1 2.8286 3.5789 2.7072 7.42
NCI-H358 GDSC1 2.845 4.5087 2.3133 10.2832
NCI-H1755 GDSC1 2.8602 3.9405 2.5909 8.1098
NCI-H2869 GDSC1 2.8821 8.3704 0.4438 23.2469
EMC-BAC-1 GDSC1 2.8884 4.1888 2.5063 8.6141
NCI-H2172 GDSC1 2.8927 3.3909 2.8404 6.1385
PaCa-3 GDSC1 2.9305 4.9207 2.196 10.815
HCC78 GDSC1 2.9376 3.6335 2.8022 6.168
NCI-H748 GDSC1 2.9574 4.4118 2.4679 8.5967
LXF 289 GDSC1 2.9726 4.0396 2.6589 7.0661
PC-14 GDSC1 2.9869 5.964 1.733 14.085
NCI-H2591 GDSC1 3.0083 5.7453 1.8606 13.085
A-427 GDSC1 3.0123 5.1405 2.1634 10.7263
COR-L23 GDSC1 3.0151 4.051 2.6954 6.5932
Lu-99A GDSC1 3.0157 4.6115 2.4263 8.6667
NCI-H1436 GDSC1 3.0338 9.8793 -0.1778 25.8811
COR-L303 GDSC1 3.0803 3.7845 2.8839 4.8609
DMS 273 GDSC1 3.0942 9.6966 -0.035 24.876
NCI-H2803 GDSC1 3.1014 7.5186 1.059 18.4629
NCI-H661 GDSC1 3.1075 3.9604 2.8281 5.1618
HARA [Human squamous cell lung carcinoma] GDSC1 3.1091 5.7624 1.9414 12.061
NCI-H322M GDSC1 3.117 4.7479 2.4522 8.0452
NCI-H2795 GDSC1 3.1203 4.0968 2.7747 5.4939
SBC-5 GDSC1 3.1221 3.7218 2.9545 4.1315
NCI-H446 GDSC1 3.135 10.1969 -0.2502 25.8314
NCI-H2171 GDSC1 3.1361 4.0472 2.8136 5.1485
NCI-H196 GDSC1 3.1631 4.2425 2.7433 5.5809
EMC-BAC-2 GDSC1 3.1634 4.0994 2.8138 5.0304
NCI-H1781 GDSC1 3.1993 4.0241 2.8839 4.3345
LCLC-103H GDSC1 3.2488 5.4261 2.2304 9.2702
SK-MES-1 GDSC1 3.2501 4.4346 2.7262 5.3659
Lu-134-A GDSC1 3.2534 9.1969 0.3498 22.3078
NCI-H1915 GDSC1 3.2621 4.9378 2.4856 7.2139
NCI-H650 GDSC1 3.2679 4.1098 2.9034 3.9034
NCI-H2085 GDSC1 3.289 6.8588 1.5485 14.3477
COR-L311 GDSC1 3.3076 8.2705 0.8584 19.0517
NCI-H460 GDSC1 3.3095 4.4437 2.773 4.7708
NCI-H1299 GDSC1 3.3293 4.9594 2.5321 6.5966
NCI-H1623 GDSC1 3.3332 4.4545 2.7877 4.5665
NCI-H226 GDSC1 3.3348 4.1353 2.9486 3.2924
BEN GDSC1 3.3461 4.4319 2.8099 4.3445
LK-2 GDSC1 3.378 4.8038 2.6505 5.4867
NCI-H82 GDSC1 3.3788 4.632 2.737 4.8018
NCI-H2810 GDSC1 3.3863 5.6938 2.1892 8.697
NCI-H2087 GDSC1 3.3959 5.0327 2.5508 6.2092
NCI-H1792 GDSC1 3.4009 4.8009 2.6707 5.2459
NCI-H1092 GDSC1 3.4067 5.3445 2.4038 7.3286
NCI-H2227 GDSC1 3.4083 7.8885 1.1333 16.8564
NCI-H23 GDSC1 3.4243 4.7389 2.7207 4.7701
NCI-H1869 GDSC1 3.4435 5.1788 2.5166 6.3112
CPC-N GDSC1 3.4445 6.9362 1.6392 13.1026
NCI-H1734 GDSC1 3.4445 7.7272 1.2438 15.9607
COR-L88 GDSC1 3.4647 5.5407 2.353 7.5251
RERF-LC-KJ GDSC1 3.478 7.0768 1.5963 13.3009
NCI-H2141 GDSC1 3.4841 7.4586 1.4105 14.6357
NCI-H209 GDSC1 3.5545 14.9492 -2.2759 31.5736
NCI-H2029 GDSC1 3.5643 4.9407 2.7299 4.2343
NCI-H1770 GDSC1 3.5695 4.6706 2.8672 3.1492
Calu-6 GDSC1 3.5741 5.6552 2.3828 6.9206
HCC15 GDSC1 3.5916 5.914 2.2678 7.7624
COR-L321 GDSC1 3.5952 5.0099 2.7191 4.2221
NCI-H2081 GDSC1 3.6457 5.2146 2.6558 4.5586
SBC-1 GDSC1 3.6771 5.6601 2.4595 5.9642
NCI-H1703 GDSC1 3.6812 7.5678 1.5147 13.1887
NCI-H1155 GDSC1 3.7185 5.6093 2.5154 5.4272
Lu-139 GDSC1 3.7687 12.6955 -0.9743 26.6566
ChaGo-K-1 GDSC1 3.8029 6.9583 1.9125 9.8167
NCI-H2373 GDSC1 3.8147 7.4313 1.687 11.4743
IA-LM GDSC1 3.8612 5.8704 2.491 5.1958
NCI-H2228 GDSC1 3.8881 5.8092 2.5396 4.7486
DMS 79 GDSC1 3.9053 7.5994 1.673 11.2836
NCI-H841 GDSC1 3.9065 7.1582 1.892 9.6434
COLO 668 GDSC1 3.9635 10.043 0.5045 18.8769
Lu-165 GDSC1 3.989 5.7667 2.6287 3.8087
NCI-H1694 GDSC1 4.07 6.0735 2.5365 4.2895
NCI-H1648 GDSC1 4.0721 6.2831 2.4377 5.0005
COR-L95 GDSC1 4.0737 7.3278 1.9319 8.8342
NCI-H345 GDSC1 4.0934 5.2227 2.9421 1.3727
NCI-H2009 GDSC1 4.1264 5.9576 2.6276 3.4814
NCI-H1563 GDSC1 4.1557 11.2919 0.0334 20.8328
HCC827 GDSC1 4.1747 6.1212 2.5817 3.7011
SK-LU-1 GDSC1 4.1885 9.1321 1.1292 14.2203
NCI-H1975 GDSC1 4.2195 10.049 0.6992 16.8742
NCI-H1963 GDSC1 4.2451 6.5737 2.4142 4.756
NCI-H596 GDSC1 4.29 9.8121 0.8696 15.5923
NCI-H1793 GDSC1 4.3112 6.5012 2.4904 4.0431
NCI-H2170 GDSC1 4.3523 6.1113 2.6934 2.534
LOU-NH91 GDSC1 4.361 7.3977 2.099 6.7861
NCI-H1650 GDSC1 4.3702 9.9422 0.8653 15.3702
NCI-H2369 GDSC1 4.4151 7.3525 2.1566 6.2236
NCI-H2722 GDSC1 4.4302 11.0258 0.3755 18.11
NCI-H2595 GDSC1 4.4452 8.3885 1.6797 9.6187
EBC-1 GDSC1 4.4506 7.7035 2.013 7.1838
NCI-H1304 GDSC1 4.4625 6.046 2.7829 1.7574
NCI-H2342 GDSC1 4.483 6.6316 2.535 3.354
NCI-H2804 GDSC1 4.4971 7.9382 1.9321 7.6208
LB647-SCLC GDSC1 4.5274 6.3566 2.6524 2.1965
NCI-H1838 GDSC1 4.5283 7.2321 2.2862 5.0092
NCI-H2347 GDSC1 4.6182 9.6221 1.2025 12.4395
NCI-H1993 GDSC1 4.6475 7.4035 2.2806 4.7786
ABC-1 GDSC1 4.6593 11.0274 0.5449 16.4414
NCI-H720 GDSC1 4.8402 6.4438 2.804 1.1221
NCI-H1573 GDSC1 4.8422 6.7419 2.6826 1.782
HCC33 GDSC1 4.8573 12.0021 0.2114 17.7343
NCI-H1836 GDSC1 4.8846 6.2779 2.8888 0.6815
NCI-H187 GDSC1 4.8885 13.7746 -0.6377 21.7909
LC-1/sq GDSC1 4.9017 9.377 1.5159 9.5444
NCI-H2405 GDSC1 4.9656 8.8229 1.8194 7.2883
NCI-H2023 GDSC1 4.9961 6.9242 2.6827 1.5738
NCI-H2444 GDSC1 5.0446 6.5228 2.863 0.6574
HOP-62 GDSC1 5.0612 17.8042 -2.5008 27.9086
NCI-H1435 GDSC1 5.0681 6.4415 2.903 0.4894
NCI-H2818 GDSC1 5.0969 6.9799 2.7077 1.32
NCI-H2122 GDSC1 5.1434 6.7196 2.8298 0.7131
NCI-H1437 GDSC1 5.1974 7.2647 2.6398 1.5471
RERF-LC-MS GDSC1 5.2071 6.9832 2.7559 0.9747
Calu-3 GDSC1 5.2121 6.8608 2.8051 0.7591
NCI-H1666 GDSC1 5.2371 7.5087 2.559 1.9408
DMS 114 GDSC1 5.2598 10.9385 1.0101 11.9456
NCI-H3255 GDSC1 5.2796 7.3231 2.6545 1.3835
Lu-65 GDSC1 5.3856 7.2487 2.7305 0.9223
NCI-H524 GDSC1 5.4082 7.0252 2.8237 0.5492
NCI-H1355 GDSC1 5.4708 7.777 2.5609 1.6415
NCI-H69 GDSC1 5.4924 7.3904 2.7217 0.874
SW1573 GDSC1 5.5288 8.0283 2.4864 1.962
NCI-H2291 GDSC1 5.6112 7.5909 2.6955 0.886
NCI-H727 GDSC1 5.6484 7.3571 2.797 0.4969
NCI-H2461 GDSC1 5.6543 7.9247 2.5855 1.3259
EKVX GDSC1 5.658 8.3632 2.4113 2.2032
NCI-H1693 GDSC1 5.7057 13.164 0.2452 15.2523
NCI-H1651 GDSC1 5.7143 7.3535 2.8234 0.3871
RERF-LC-Sq1 GDSC1 5.7708 12.5715 0.5721 13.2825
NCI-H1568 GDSC1 5.8576 7.8027 2.7167 0.6369
NCI-H526 GDSC1 5.9758 14.3108 -0.1217 16.4665
DMS 53 GDSC1 5.9931 7.8279 2.7598 0.4346
NCI-H513 GDSC1 6.0104 8.0897 2.672 0.6949
HOP-92 GDSC1 6.1462 8.4094 2.6085 0.8299
NCI-H441 GDSC1 6.1919 8.0427 2.7579 0.3572
A-549 GDSC1 6.2338 8.0711 2.7633 0.328
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 1.3087 5.9341 0.1233 32.5194
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 2.2085 6.2696 0.8594 23.7226
KYSE-270 GDSC1 2.5249 3.7567 2.315 11.8244
T.T GDSC1 2.5486 3.4446 2.4492 10.7534
KYSE-140 GDSC1 2.6878 7.7304 0.5898 23.1303
TE-8 GDSC1 2.7661 7.3699 0.8386 21.3487
OE33 GDSC1 2.9745 4.3155 2.5304 8.0402
KYSE-450 GDSC1 3.0673 3.6406 2.9349 4.5416
TE-10 GDSC1 3.3184 4.4624 2.7712 4.7517
TE-6 GDSC1 3.4631 6.8324 1.7063 12.533
KYSE-410 GDSC1 3.6528 5.1379 2.6987 4.1864
KYSE-510 GDSC1 3.8597 5.231 2.7978 2.8787
KYSE-150 GDSC1 3.9258 5.4071 2.7577 3.0114
OE21 GDSC1 4.2671 7.433 2.0179 7.6385
KYSE-70 GDSC1 4.5653 6.8771 2.4721 3.6182
OE19 GDSC1 4.6494 5.9723 2.9047 0.8307
EC-GI-10 GDSC1 4.9382 7.9709 2.1959 4.7448
TE-1 GDSC1 5.1072 6.7389 2.8071 0.8393
TE-11 GDSC1 5.2302 7.3932 2.6031 1.7085
TE-9 GDSC1 5.3355 6.7438 2.8974 0.3572
KYSE-520 GDSC1 5.4489 13.5597 -0.1242 17.8294
TE-4 GDSC1 5.5551 7.4298 2.7329 0.781
COLO 680N GDSC1 5.5735 7.1577 2.8399 0.4068
TE-5 GDSC1 5.7215 7.5439 2.7576 0.582
KYSE-180 GDSC1 6.3808 17.1191 -1.1967 20.2317
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES-2 GDSC1 0.1165 2.8803 -0.0617 41.2952
OVKATE GDSC1 1.8181 12.8508 -2.7269 38.4759
IGROV-1 GDSC1 2.3039 3.2822 2.2272 13.6532
A2780 GDSC1 2.4054 3.2092 2.3547 12.2125
Caov-4 GDSC1 2.4163 7.9647 0.2283 26.4259
RMG-I GDSC1 2.5309 3.9321 2.2521 12.2469
JHOS-2 GDSC1 2.7129 7.4561 0.7482 22.1437
OAW28 GDSC1 2.8242 4.164 2.4537 9.3109
TOV-112D GDSC1 2.8757 3.7681 2.6816 7.3623
OC 314 GDSC1 2.8888 7.2494 1.0076 19.7359
SK-OV-3 GDSC1 2.994 4.1667 2.6202 7.2645
Caov-3 GDSC1 3.0934 3.7996 2.8899 4.7541
OVTOKO GDSC1 3.0972 5.1801 2.2203 9.9382
OVISE GDSC1 3.3739 9.6105 0.2437 22.4376
OVCAR-5 GDSC1 3.3769 4.4512 2.8258 4.1083
OV56 GDSC1 3.406 4.2009 2.9746 2.8336
DOV13 GDSC1 3.4667 6.5999 1.8255 11.569
FU-OV-1 GDSC1 3.7463 6.0151 2.3362 6.7331
OV-90 GDSC1 3.8244 5.1842 2.7968 2.976
TYK-nu GDSC1 3.9738 5.4234 2.7807 2.7286
OAW42 GDSC1 4.6448 6.8389 2.5353 3.0327
OVK18 GDSC1 4.6683 6.6144 2.6469 2.2673
TOV-21G GDSC1 4.699 6.4404 2.7371 1.6708
OVCAR-4 GDSC1 4.9164 15.4616 -1.4506 24.9485
EFO-27 GDSC1 5.0498 12.9261 -0.1013 18.8099
Kuramochi GDSC1 5.2624 13.9658 -0.4561 19.9233
OVCAR-3 GDSC1 5.6439 7.3384 2.802 0.4838
OVCAR-8 GDSC1 6.0233 15.3166 -0.5736 18.4789
EFO-21 GDSC1 7.5914 20.8547 -2.1648 21.0438
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 0.619 4.5963 -0.0422 37.5185
SUIT-2 GDSC1 1.1587 3.8918 0.793 29.7754
HPAC GDSC1 2.6768 7.3068 0.7896 22.04
PSN1 GDSC1 2.8658 3.6938 2.7021 7.2628
BxPC-3 GDSC1 2.9125 4.4087 2.4261 9.1171
Panc 03.27 GDSC1 3.0212 4.2648 2.5995 7.3021
Panc 08.13 GDSC1 3.0765 6.7523 1.4197 16.1097
Panc 02.03 GDSC1 3.1351 3.9181 2.8749 4.6798
HuP-T4 GDSC1 3.2178 5.945 1.9447 11.5664
DAN-G GDSC1 3.3311 4.3499 2.8382 4.1764
HPAF-II GDSC1 3.3648 4.4729 2.805 4.3154
PaTu 8988t GDSC1 3.4071 5.0867 2.5329 6.3101
PaTu 8902 GDSC1 3.5353 4.4732 2.939 2.6951
PL4 GDSC1 3.6203 6.2669 2.1147 8.8595
HuP-T3 GDSC1 3.7069 5.4017 2.6089 4.7176
Capan-2 GDSC1 3.7258 5.1069 2.7664 3.4707
Panc 10.05 GDSC1 3.9241 5.6521 2.64 3.8919
SU.86.86 GDSC1 3.9854 6.38 2.3311 6.065
CFPAC-1 GDSC1 4.0491 6.9718 2.0882 7.7278
KP-4 GDSC1 4.1261 5.7658 2.7165 2.8434
KP-3 GDSC1 4.3927 9.74 0.9815 14.559
KP-2 GDSC1 4.5321 6.5262 2.6107 2.7438
SW1990 GDSC1 4.7157 7.1935 2.4171 3.6893
MIA PaCa-2 GDSC1 4.783 7.4741 2.3297 4.1494
Panc 04.03 GDSC1 4.8139 8.1792 2.0242 6.2102
Capan-1 GDSC1 4.8609 6.3968 2.8322 0.9562
YAPC GDSC1 4.923 6.3745 2.8681 0.7365
AsPC-1 GDSC1 5.7634 12.5832 0.5616 13.3604
Hs 766T GDSC1 6.1445 7.9388 2.7768 0.3304
QGP-1 GDSC1 6.7288 16.9978 -0.8999 18.2244
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 1.968 7.0417 0.2588 28.2672
MPP 89 GDSC1 2.4809 4.3867 2.0059 14.308
NCI-H28 GDSC1 3.0927 5.6454 1.9852 11.7375
NCI-H2052 GDSC1 4.5058 10.0295 0.9224 14.5958
MSTO-211H GDSC1 5.3672 7.448 2.6447 1.3315
NCI-H2452 GDSC1 5.611 7.9322 2.5632 1.4759
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 2.7795 3.854 2.5451 8.8473
LNCaP clone FGC GDSC1 2.949 4.1372 2.5901 7.6979
22Rv1 GDSC1 2.9529 3.774 2.759 6.4079
PC-3 GDSC1 3.4194 5.5896 2.2917 8.1653
VCaP GDSC1 5.493 6.8292 2.9256 0.2231
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.1234 5.9913 2.6099 3.6171
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Mel Ho GDSC1 -0.1166 2.5511 -0.2482 43.8934
UACC-257 GDSC1 1.537 3.4884 1.3333 24.0747
IGR-1 GDSC1 1.7435 2.8504 1.704 20.3227
WM35 GDSC1 1.7759 3.5019 1.5897 20.9828
SK-MEL-3 GDSC1 1.8716 3.2601 1.7612 19.2766
CHL-1 GDSC1 1.9618 4.236 1.5284 20.3973
MZ-MEL-7 GDSC1 1.9946 3.8368 1.716 18.901
WM278 GDSC1 2.1844 5.9553 0.9858 23.0223
IGR-37 GDSC1 2.2131 3.6764 2.0086 15.6636
G-361 GDSC1 2.3285 3.3386 2.2394 13.4295
HMV-II GDSC1 2.3768 4.7017 1.7592 16.6397
SK-MEL-24 GDSC1 2.4467 4.8835 1.7461 16.4037
Mel JuSo GDSC1 2.5312 6.7761 0.918 21.8591
SK-MEL-30 GDSC1 2.5374 3.634 2.3738 11.3402
IST-MEL1 GDSC1 2.5467 7.196 0.7259 23.004
M14 GDSC1 2.5688 9.533 -0.4107 28.8133
SH-4 GDSC1 2.6041 6.7003 1.0223 20.8513
WM793 GDSC1 2.6974 9.0113 -0.0375 26.5618
G-mel GDSC1 2.7428 3.569 2.6186 8.5064
A-431 GDSC1 2.7972 3.5176 2.6956 7.671
MZ-MEL-2 GDSC1 2.7995 3.8006 2.5883 8.4296
IPC-298 GDSC1 2.834 3.2807 2.805 6.7144
GAK GDSC1 2.9434 3.8386 2.721 6.7369
WT2-iPS GDSC1 3.0778 3.6925 2.9229 4.5599
RVH-421 GDSC1 3.1303 10.0421 -0.1768 25.5035
A2058 GDSC1 3.1662 3.7926 2.9647 3.835
A-375 GDSC1 3.1879 4.9295 2.4252 7.94
SK-MEL-28 GDSC1 3.201 5.0788 2.3624 8.4169
VMRC-MELG GDSC1 3.2741 4.4492 2.7399 5.144
WM115 GDSC1 3.2898 4.0247 2.965 3.3336
SK-MEL-1 GDSC1 3.2908 4.0807 2.938 3.5422
Hs 938.T GDSC1 3.3009 5.3869 2.2943 8.5736
LB373-MEL-D GDSC1 3.3157 4.2454 2.8774 3.9252
SK-MEL-5 GDSC1 3.3634 6.8269 1.6268 13.4901
COLO 679 GDSC1 3.42 4.7715 2.7009 4.9411
RPMI-7951 GDSC1 3.4481 5.0181 2.6005 5.6107
COLO 792 GDSC1 3.4713 4.7253 2.765 4.2614
A101D GDSC1 3.4726 4.5838 2.8365 3.6951
MMAc-SF GDSC1 3.5823 5.2741 2.5785 5.3611
LOX-IMVI GDSC1 3.6024 4.8455 2.8054 3.5145
CP50-MEL-B GDSC1 3.6183 6.4727 2.0106 9.6307
DJM-1 GDSC1 3.7125 5.7636 2.4349 6.071
LB2518-MEL GDSC1 3.9975 6.37 2.3444 5.9295
COLO 829 GDSC1 4.3163 8.4897 1.5389 10.9524
CP66-MEL GDSC1 4.3361 6.4435 2.5326 3.6854
UACC-62 GDSC1 4.4112 7.4436 2.1107 6.5698
SK-MEL-2 GDSC1 4.4599 5.7604 2.9017 1.061
COLO 783 GDSC1 4.5172 6.7841 2.4859 3.6226
A-388 GDSC1 5.0478 7.162 2.6096 1.9041
COLO 800 GDSC1 5.1129 11.3646 0.7047 14.2064
MeWo GDSC1 5.1173 6.9095 2.745 1.1135
451Lu GDSC1 5.2493 7.0636 2.7431 0.9932
WM1552C GDSC1 5.5166 7.0717 2.849 0.4084
Hs 940.T GDSC1 6.0039 7.7646 2.7861 0.3613
HT-144 GDSC1 8.5307 18.0648 -0.2645 11.8306
EquiPSC Line K2 GDSC1 4.4325 6.8401 2.4086 4.353
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 2.2328 8.0276 0.0289 28.2685
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-204 GDSC1 0.1559 4.0821 -0.3586 41.9766
G-401 GDSC1 1.0483 3.3793 0.8311 30.2128
EW-8 GDSC1 2.363 3.8932 2.0897 14.2887
Hs 633.T GDSC1 2.3819 3.4302 2.2718 12.9057
RD GDSC1 2.6471 3.4544 2.5535 9.4852
SW982 GDSC1 2.6758 3.345 2.6166 8.8924
TE 441.T GDSC1 2.7227 11.1763 -1.0936 30.845
SK-LMS-1 GDSC1 2.7493 7.723 0.6485 22.5994
VA-ES-BJ GDSC1 2.8253 3.321 2.7861 6.8912
HT-1080 GDSC1 2.8794 3.2931 2.8517 6.1387
MFH-ino GDSC1 3.0327 3.943 2.7633 5.9957
SW872 GDSC1 3.1273 4.1804 2.7406 5.7518
SK-UT-1 GDSC1 3.2265 4.0852 2.8786 4.2636
RKN GDSC1 3.2521 4.0565 2.9158 3.8687
Rh41 GDSC1 3.4122 5.1395 2.5107 6.467
G-402 GDSC1 4.3251 12.3966 -0.3841 22.3389
KYM-1 GDSC1 4.9077 6.2703 2.9014 0.6105
SW684 GDSC1 4.9414 6.3567 2.8827 0.6594
MES-SA GDSC1 5.4656 6.4793 3.034 0.0593
Rh30 GDSC1 5.5171 6.8165 2.9386 0.1889
GCT GDSC1 5.6102 7.4342 2.7537 0.665
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KATO III GDSC1 -0.3486 3.272 -0.6703 46.5532
RF-48 GDSC1 -0.2549 5.6291 -1.3749 46.924
RERF-GC-1B GDSC1 0.9756 4.2335 0.4751 32.7336
SNU-1 GDSC1 1.3118 2.9759 1.2162 26.1669
NUGC-4 GDSC1 1.8074 3.3359 1.6715 20.2492
23132/87 GDSC1 2.4556 4.2876 2.0235 14.3014
MKN28 GDSC1 2.7104 4.5757 2.1501 12.0877
HGC-27 GDSC1 2.7322 3.3426 2.6789 8.1484
IM95 GDSC1 2.7549 4.3168 2.3143 10.689
ECC10 GDSC1 2.786 5.0655 1.9898 13.0252
NCI-N87 GDSC1 3.0156 5.4452 2.0158 11.8083
SCH GDSC1 3.2148 3.8617 2.9776 3.5399
AGS GDSC1 3.2527 4.0154 2.9368 3.6864
Hs 746.T GDSC1 3.2806 5.5728 2.1842 9.5135
GCIY GDSC1 3.2898 5.3805 2.2882 8.6633
MKN45 GDSC1 3.3405 4.0849 2.9786 3.0349
TMK-1 GDSC1 3.6426 6.0791 2.2254 7.8913
NUGC-3 GDSC1 3.6877 5.5193 2.5369 5.3543
MKN1 GDSC1 3.6881 5.3897 2.601 4.8554
TGBC11TKB GDSC1 4.0428 5.9784 2.5636 4.1566
SNU-16 GDSC1 4.4937 6.0236 2.8087 1.5453
MKN7 GDSC1 4.5792 9.885 1.0464 13.5811
OCUM-1 GDSC1 4.6325 6.6965 2.5915 2.6848
Fu97 GDSC1 5.3178 11.2153 0.9167 12.3769
HSC-39 GDSC1 5.4893 7.0415 2.8494 0.4209
SNU-5 GDSC1 5.5186 6.8808 2.917 0.2333
SNG-M GDSC1 2.0021 3.9335 1.6886 19.0527
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 2.0377 2.5571 2.0359 16.4917
CGTH-W-1 GDSC1 2.3985 3.5722 2.245 12.9432
BHT-101 GDSC1 2.4573 3.5628 2.3119 12.2098
TT2609-C02 GDSC1 2.5694 5.0092 1.8082 15.3708
8505C GDSC1 2.6595 6.991 0.9298 21.1382
IHH-4 GDSC1 2.7237 3.44 2.6413 8.4529
HTC-C3 GDSC1 2.8701 6.4438 1.3906 17.1572
K5 GDSC1 2.9115 3.93 2.6478 7.4377
CAL-62 GDSC1 2.9575 3.7475 2.7753 6.2383
ML-1 [Human leukemia] GDSC1 3.2682 6.5217 1.6995 13.2988
WRO GDSC1 3.4077 4.7588 2.6973 5.0129
8305C GDSC1 3.7253 4.8872 2.8721 2.6693
KMH-2 GDSC1 4.3187 6.0652 2.6948 2.5908
TT GDSC1 4.45 6.7426 2.4644 3.9173
FTC-133 GDSC1 4.6677 6.6645 2.6248 2.4078
ASH-3 GDSC1 5.3903 6.8068 2.8957 0.3364
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHY GDSC1 2.1183 3.2286 2.0378 15.9963
SCC-25 GDSC1 2.2334 3.3081 2.1437 14.6205
PCI-06A GDSC1 2.5043 6.7319 0.9146 22.0011
PCI-38 GDSC1 2.5759 4.0947 2.231 12.1745
SCC-9 GDSC1 2.7593 3.8118 2.5417 8.9737
SKN-3 GDSC1 2.8181 3.9403 2.5479 8.6352
BB30-HNC GDSC1 2.8683 3.3985 2.8116 6.4733
NCI-H3118 GDSC1 2.8866 3.8715 2.6484 7.5537
KOSC-2 GDSC1 2.9004 4.2067 2.5098 8.5321
PCI-04B GDSC1 2.9604 3.9267 2.6987 6.8224
LB771-HNC GDSC1 2.9779 4.1 2.6359 7.2167
BB49-HNC GDSC1 3.0015 4.0291 2.6924 6.6787
Ca9-22 GDSC1 3.0822 4.3395 2.6209 6.8734
HSC-3 GDSC1 3.1115 3.749 2.9314 4.3559
SCC-15 GDSC1 3.1426 3.9805 2.8521 4.8228
OSC-19 GDSC1 3.1865 3.9533 2.9066 4.2121
JHU-011 GDSC1 3.2058 5.2192 2.2965 8.9157
HSC-2 GDSC1 3.4431 4.3418 2.9338 3.0293
JHU-022 GDSC1 3.4722 4.9135 2.672 4.9898
HO-1-u-1 GDSC1 3.4856 5.0698 2.6047 5.4738
CAL-33 GDSC1 3.4863 5.2642 2.5083 6.2027
HSC-4 GDSC1 3.5072 4.8098 2.7511 4.252
DOK GDSC1 3.5111 4.9607 2.6791 4.7837
SAS GDSC1 3.5134 6.2628 2.0317 9.8668
CAL-27 GDSC1 3.6689 4.8378 2.8571 2.9373
PE/CA-PJ15 GDSC1 3.7013 5.3863 2.6124 4.7277
FaDu GDSC1 3.9477 5.977 2.4999 4.8656
OSC-20 GDSC1 4.0166 6.9311 2.0847 7.8495
BICR 22 GDSC1 4.0345 12.0387 -0.4335 23.4984
SAT [Human HNSCC] GDSC1 4.0773 6.6904 2.2451 6.4603
BICR 78 GDSC1 4.3485 6.5874 2.4736 4.0783
Detroit 562 GDSC1 4.3505 6.125 2.6863 2.5858
HO-1-N-1 GDSC1 4.4083 6.5033 2.5489 3.4132
SCC-4 GDSC1 4.5392 7.2194 2.2989 4.893
BICR 31 GDSC1 4.5474 6.3753 2.6857 2.2271
BICR 10 GDSC1 4.8959 6.807 2.6822 1.7096
PCI-15A GDSC1 5.4572 7.9994 2.4637 2.1776
PCI-30 GDSC1 5.6495 7.4552 2.7617 0.6119
KON GDSC1 5.7818 7.4747 2.8057 0.4048
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1 1.8022 7.5965 -0.1662 31.2282
SW1710 GDSC1 2.2443 4.0368 1.907 16.2203
UM-UC-3 GDSC1 2.6129 3.8229 2.3828 10.8777
5637 GDSC1 2.6304 3.7666 2.4237 10.4917
BFTC-905 GDSC1 2.72 3.4372 2.6382 8.4948
CAL-29 GDSC1 2.9608 3.6409 2.8236 5.8938
TCCSUP GDSC1 2.9689 3.5136 2.882 5.431
647V GDSC1 3.1889 3.9353 2.9176 4.1157
639V GDSC1 3.8427 5.7257 2.5483 4.81
RT-112 GDSC1 4.3584 10.8826 0.392 18.241
J82 GDSC1 4.3894 6.008 2.7601 2.0244
SW780 GDSC1 4.498 6.6068 2.555 3.1861
KU-19-19 GDSC1 4.9883 6.2538 2.9402 0.4095
HT-1197 GDSC1 5.2591 6.7289 2.8733 0.4727
T24 GDSC1 5.4976 10.1149 1.5509 7.8851
HT-1376 GDSC1 6.1703 7.7462 2.852 0.1755
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB831-BLC GDSC1 1.1206 4.2167 0.6372 30.9315
C-33 A GDSC1 1.1415 4.0813 0.7085 30.3875
Ca Ski GDSC1 2.1416 8.2914 -0.1846 29.6904
HEY GDSC1 2.3291 4.2069 1.9267 15.5772
SW954 GDSC1 2.4661 3.7117 2.2688 12.4656
SW962 GDSC1 2.4749 3.6102 2.3147 12.0943
PA-1 GDSC1 2.4843 3.9294 2.2041 12.8342
BPH-1 GDSC1 2.7896 4.9348 2.0562 12.5012
KGN GDSC1 2.7951 3.6937 2.6273 8.1688
PEO1 GDSC1 2.8392 5.0818 2.032 12.4707
NEC8 GDSC1 2.8974 3.3853 2.8473 6.0651
OV17R GDSC1 2.993 10.269 -0.4074 27.092
OVMIU GDSC1 3.0644 7.1472 1.2123 17.6311
NCC-IT GDSC1 3.0734 3.8052 2.8675 5.0175
OVCA420 GDSC1 3.1306 3.9605 2.8502 4.8899
OMC-1 [Human cervical carcinoma] GDSC1 3.5483 5.3159 2.5314 5.8407
ACC-OV7 GDSC1 3.6892 5.5843 2.506 5.5902
UWB1.289 GDSC1 3.838 12.308 -0.7248 25.4202
JHOS-3 GDSC1 3.86 6.3886 2.2366 7.1546
OVCA433 GDSC1 3.9424 7.1428 1.9264 9.2723
DoTc2 4510 GDSC1 3.9922 6.8359 2.1137 7.6693
ME-180 GDSC1 4.0359 10.6768 0.2457 20.0975
DSH1 GDSC1 4.228 6.3029 2.5305 3.9471
HT-3 GDSC1 4.2624 7.0098 2.2182 6.1619
HeLa GDSC1 4.2704 6.1682 2.6193 3.2156
SiSo GDSC1 4.2773 6.8302 2.3138 5.4154
JAR GDSC1 4.4202 6.3866 2.609 2.9737
MS751 GDSC1 4.4529 6.602 2.5305 3.4474
SW756 GDSC1 4.5534 7.0147 2.4022 4.13
CAL-39 GDSC1 4.5593 8.1025 1.8953 7.7565
NT2-D1 GDSC1 4.9137 14.5328 -0.9932 23.2148
JEG-3 GDSC1 4.9806 6.5091 2.8411 0.8033
C-4-I GDSC1 5.0445 7.1102 2.6295 1.7969
HEC-1 GDSC1 5.0818 6.4863 2.8919 0.5199
SiHa GDSC1 5.0989 6.6233 2.8477 0.6763
SKG-IIIa GDSC1 5.557 7.1197 2.8472 0.3939
SKN GDSC1 6.1155 7.85 2.7971 0.2948
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.