Details of the Drug

General Information of Drug (ID: DMC84Y9)

Drug Name
Tepoditamab
Synonyms MCLA-117
Indication
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Phase 1 [1]
Drug Type
Antibody
Cross-matching ID
TTD ID
D2Q3VY
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Myeloid inhibitory C-type lectin-like receptor (CD371) TT70N8V CL12A_HUMAN Not Available [2]
T-cell surface glycoprotein CD3 (CD3) TTUN7MC NOUNIPROTAC Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03038230) MCLA-117 in Acute Myelogenous Leukemia. U.S. National Institutes of Health.
2 MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis. Expert Opin Biol Ther. 2019 Jul;19(7):721-733.