Details of the Drug

General Information of Drug (ID: DMCGX9U)

Drug Name
PHA-665752
Synonyms
PHA-665752; 477575-56-7; PHA 665752; PHA665752; TCMDC-125885; UNII-0VXU5T5R3J; (2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE; 0VXU5T5R3J; CHEMBL450786; CHEBI:90197; (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one; PHA-665752 hydrate
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 641.6
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C32H34Cl2N4O4S
IUPAC Name
(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
Canonical SMILES
CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
InChI
InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1
InChIKey
OYONTEXKYJZFHA-SSHUPFPWSA-N
Cross-matching ID
PubChem CID
10461815
ChEBI ID
CHEBI:90197
CAS Number
477575-56-7
TTD ID
D00TBD

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [4]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Gene/Protein Processing [4]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Met (MET) DTT MET 1.08E-03 -0.24 -0.4
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.069 5.0045 0.3483 1.0042
ALL-PO GDSC1 -0.3493 10.2526 -4.7939 37.2726
MV4-11 GDSC1 0.3729 2.5207 -0.3302 13.0006
Mono-Mac-1 CCLE 0.7433 4.0222 0.1983 21.9101
Namalwa GDSC1 1.0649 2.3222 0.3922 4.5637
MOLT-16 GDSC1; CCLE 1.1661 2.5421 1.1024 16.0305
Karpas-45 GDSC1 1.1959 2.454 0.4291 3.8406
DEL GDSC1; CCLE 1.2915 1.826 1.291 14.675
SU-DHL-4 GDSC1; CCLE 1.3367 2.552 1.2846 14.5135
MY-M12 GDSC1 1.3833 3.1778 0.2117 4.9587
L-363 GDSC1; CCLE 1.4091 3.2824 1.1792 14.7168
MOLT-13 GDSC1 1.4155 3.513 0.0707 5.953
KMM-1 CCLE 1.4615 4.0135 0.9662 15.5635
ALL-SIL GDSC1; CCLE 1.4865 4.203 0.9147 15.7322
697 GDSC1; CCLE 1.6035 3.311 1.381 13.0172
NK-92MI GDSC1 1.628 3.4879 0.2325 4.1208
NCO2 CCLE 1.6324 3.7294 1.26 13.4991
NALM-6 GDSC1 1.6703 3.2789 0.359 3.081
SUP-B15 GDSC1 1.6819 3.577 0.2259 4.032
BC-1 GDSC1 1.7279 3.4791 0.3018 3.3607
CTV-1 GDSC1 1.7851 3.6494 0.2585 3.541
KE-37 GDSC1 1.8033 3.5494 0.3163 3.0828
A3/Kawakami GDSC1 1.8239 3.6137 0.2993 3.1582
P32/ISH GDSC1 1.8366 3.2887 0.4548 2.052
Karpas-299 GDSC1; CCLE 1.9126 3.2345 1.7419 10.1234
SU-DHL-6 GDSC1; CCLE 1.9462 2.8054 1.8966 9.2701
DoHH2 GDSC1; CCLE 2.0711 4.7828 1.2519 12.0669
AMO1 GDSC1; CCLE 2.0963 2.7522 2.0687 7.8821
Karpas-231 GDSC1 2.098 3.712 0.4128 1.8578
HuT 78 CCLE 2.1011 5.0168 1.1708 12.3977
SKM-1 GDSC1 2.1094 6.5644 -0.9206 11.2882
MEC-1 CCLE 2.1638 4.3212 1.5579 10.1782
KHM-1B CCLE 2.2131 3.5637 1.9413 8.053
YT GDSC1 2.2453 3.7709 0.4633 1.3356
SU-DHL-1 GDSC1 2.2612 4.5725 0.1232 3.4629
Karpas-422 GDSC1; CCLE 2.3307 3.3478 2.1521 6.5885
GDM-1 GDSC1 2.3402 5.5189 -0.2641 6.0044
MOLP-8 GDSC1; CCLE 2.3444 3.979 1.8954 7.8454
KCL-22 GDSC1; CCLE 2.4333 4.2807 1.8424 7.8409
NB4 GDSC1 2.4468 3.7545 0.5619 0.627
Mono-Mac-6 GDSC1 2.4579 6.7547 -0.7718 9.2991
GA-10 GDSC1 2.4772 3.9044 0.5172 0.7953
MOLT-4 GDSC1 2.4891 4.8244 0.1398 2.9239
DB GDSC1 2.5268 4.1088 0.459 1.0197
HL-60 GDSC1 2.5291 3.6199 0.6446 0.2788
IM-9 GDSC1 2.5458 3.879 0.5562 0.5714
P31/FUJ GDSC1; CCLE 2.5592 3.8908 2.1494 5.8378
BALL-1 GDSC1 2.563 4.1224 0.4699 0.9303
SCC-3 GDSC1 2.5738 3.9437 0.5434 0.6005
Pfeiffer CCLE 2.5788 5.4164 1.425 9.6418
SUP-HD1 GDSC1 2.5928 6.9126 -0.7576 8.8567
THP-1 GDSC1 2.6227 4.7169 0.2562 1.9941
HAL-01 GDSC1 2.628 6.9779 -0.7654 8.8229
OCI-AML-3 GDSC1 2.6433 4.0884 0.5176 0.6495
SU-DHL-16 GDSC1 2.6496 3.8993 0.5903 0.3807
CESS GDSC1 2.6633 4.6071 0.3218 1.57
H9 GDSC1 2.677 6.879 -0.687 8.1649
CMK-86 CCLE 2.6974 4.9215 1.7768 7.4213
VAL GDSC1 2.7165 9.6641 -1.9982 16.3184
KOPN-8 GDSC1 2.735 5.1952 0.1109 2.6928
OCI-M1 GDSC1 2.7633 3.8801 0.6398 0.1949
CCRF-CEM GDSC1 2.7947 5.4441 0.0353 3.0635
KG-1 GDSC1; CCLE 2.8178 3.947 2.3673 3.9104
WSU-DLCL2 GDSC1 2.8212 3.9504 0.6364 0.1831
ST486 GDSC1 2.8264 5.0606 0.2142 1.9504
ME1 GDSC1 2.838 9.3624 -1.7662 14.6634
SIG-M5 GDSC1; CCLE 2.8424 4.9548 1.8883 6.4277
SR GDSC1 2.8593 4.8972 0.2966 1.465
JURL-MK1 GDSC1 2.8702 4.578 0.427 0.8385
MN-60 GDSC1 2.8735 5.5957 0.0117 3.0794
HD-MY-Z CCLE 2.8928 4.5795 2.1193 5.046
JSC-1 GDSC1 2.8933 4.3957 0.5049 0.5201
U-937 CCLE 2.9172 4.5714 2.1443 4.847
SU-DHL-8 GDSC1; CCLE 2.9192 4.5217 2.1708 4.6983
K-562 GDSC1 2.9217 4.4085 0.5115 0.4803
EJM GDSC1 2.9275 4.627 0.4325 0.7685
P12-Ichikawa CCLE 2.9312 6.5032 1.1908 9.9648
Loucy GDSC1 2.9358 5.0028 0.2897 1.4134
NU-DUL-1 GDSC1 2.9384 4.376 0.5298 0.4121
Reh GDSC1; CCLE 2.9704 5.0697 1.9404 5.8158
CA46 GDSC1 3.0225 5.5551 0.1055 2.296
Ci-1 CCLE 3.0443 4.8666 2.1034 4.7494
Farage GDSC1 3.0491 4.3342 0.5859 0.2168
F-36P CCLE 3.0882 5.2714 1.9369 5.5446
A4/Fukuda GDSC1 3.0948 4.5125 0.5404 0.3078
BE-13 GDSC1 3.1009 18.6111 -6.1219 30.0886
OPM-2 GDSC1; CCLE 3.107 4.9752 2.1001 4.6164
BC-3 GDSC1 3.1094 4.61 0.5112 0.3804
MOLM-13 GDSC1 3.1363 12.4636 -3.0636 20.4291
SUP-M2 GDSC1; CCLE 3.1502 4.9923 2.1261 4.3746
PF-382 GDSC1 3.1523 4.8014 0.4588 0.5184
KE-97 CCLE 3.1548 5.4898 1.8816 5.6858
KY821 GDSC1 3.1607 4.8168 0.4564 0.5213
HC-1 GDSC1 3.1643 5.0551 0.3694 0.8365
KMS-11 CCLE 3.1665 5.856 1.7082 6.5956
Kasumi-2 CCLE 3.1701 5.8655 1.7064 6.597
KMS-26 CCLE 3.1756 5.4426 1.9218 5.4199
EM-2 GDSC1; CCLE 3.1783 4.9754 2.1567 4.1448
MJ CCLE 3.1941 5.2731 2.0208 4.8421
RPMI-8226 GDSC1 3.213 4.8398 0.4684 0.4545
SK-MM-2 GDSC1; CCLE 3.2144 5.4676 1.94 5.2322
HEL GDSC1 3.2145 4.5489 0.5712 0.1954
KMOE-2 GDSC1 3.2224 5.1621 0.3532 0.8559
MC116 GDSC1; CCLE 3.2258 4.6458 2.3569 2.9617
P3HR-1 CCLE 3.2406 5.9806 1.7051 6.4394
P30/OHK GDSC1 3.2496 5.0082 0.4215 0.5844
ROS-50 GDSC1 3.2534 6.7022 -0.2645 4.16
EB1 CCLE 3.2588 6.1878 1.6164 6.8762
BV-173 GDSC1 3.2681 4.9315 0.4566 0.4615
ML-2 GDSC1 3.2753 4.7435 0.5258 0.2729
BL-70 CCLE 3.3079 5.1853 2.1521 3.8828
L-428 GDSC1; CCLE 3.3088 5.897 1.8002 5.772
DND-41 GDSC1 3.3142 7.1341 -0.4208 5.0369
CRO-AP2 GDSC1 3.3154 4.9242 0.4772 0.3794
L-540 GDSC1 3.3209 5.0192 0.4453 0.4681
Karpas-620 GDSC1; CCLE 3.3502 5.5208 2.0182 4.5097
Jurkat CCLE 3.3509 6.5755 1.4956 7.3157
LP-1 GDSC1; CCLE 3.3586 5.1482 2.2081 3.4767
U266B1 GDSC1 3.3697 5.138 0.4213 0.5159
RPMI-8402 GDSC1; CCLE 3.3853 5.8183 1.8977 5.0801
Kasumi-1 GDSC1 3.3933 5.4005 0.3342 0.8023
KO52 CCLE 3.3982 6.6931 1.4739 7.3258
L-1236 GDSC1 3.3997 5.8588 0.1606 1.5486
LC4-1 GDSC1 3.4106 5.3494 0.3601 0.6954
EoL-1 GDSC1 3.4238 12.9233 -3.0823 19.7629
JVM-2 GDSC1 3.4323 6.662 -0.153 3.1988
KMS-12-BM GDSC1; CCLE 3.4357 4.8281 2.4186 2.2168
ARH-77 GDSC1 3.4426 4.8951 0.5336 0.2028
Mino CCLE 3.4435 6.0868 1.8089 5.4308
JJN-3 GDSC1 3.4437 5.1873 0.4319 0.446
MHH-PREB-1 GDSC1 3.4629 5.0402 0.4909 0.2858
RPMI-6666 GDSC1 3.466 5.0079 0.5032 0.2574
Ku812 GDSC1; CCLE 3.4666 5.7877 1.9733 4.5044
WSU-NHL GDSC1 3.472 4.9229 0.5345 0.1931
TUR GDSC1 3.4773 5.1329 0.4638 0.3453
WIL2 NS GDSC1 3.4855 4.7527 0.5964 0.0963
MLMA GDSC1 3.5262 5.6763 0.2854 0.8918
ATN-1 GDSC1 3.5517 5.211 0.4638 0.3164
Granta-519 GDSC1; CCLE 3.5553 5.6801 2.0898 3.7098
KM-H2 GDSC1 3.5598 4.8306 0.5956 0.086
EHEB GDSC1 3.5702 5.5872 0.3362 0.6773
CTB-1 GDSC1 3.5785 5.655 0.3146 0.7473
PL-21 GDSC1 3.5987 6.0738 0.1645 1.3354
Hs 445 GDSC1 3.6091 5.0871 0.5268 0.1721
Jiyoye GDSC1 3.6173 5.665 0.3263 0.682
QIMR-WIL GDSC1 3.6609 5.8774 0.2653 0.8709
BDCM CCLE 3.6732 6.4232 1.8119 4.943
Daudi GDSC1 3.7216 5.2667 0.5053 0.1814
HEL 92.1.7 CCLE 3.7285 6.0955 2.0093 3.8036
KMS-34 CCLE 3.7289 6.0361 2.0381 3.6534
Raji GDSC1; CCLE 3.7333 5.6121 2.2428 2.5967
LAMA-84 GDSC1 3.7922 5.4987 0.4511 0.2629
JVM-3 GDSC1; CCLE 3.795 5.7659 2.2102 2.6587
RPMI-8866 GDSC1 3.8562 5.5587 0.4533 0.2398
OCI-Ly19 GDSC1 3.8728 5.5633 0.4575 0.2272
VL51 GDSC1 3.886 5.7344 0.4034 0.335
MEG-01 GDSC1; CCLE 3.8929 5.8744 2.2213 2.4468
Toledo CCLE 3.9087 6.7167 1.8336 4.3844
NOMO-1 GDSC1 3.9356 14.1009 -3.2947 19.401
OCI-AML-2 GDSC1; CCLE 3.9706 6.8919 1.7914 4.49
SU-DHL-10 CCLE 4.0266 5.3527 2.5289 0.869
GR-ST GDSC1 4.1049 6.1624 0.3341 0.4174
DG-75 GDSC1 4.1245 5.8051 0.4634 0.1595
HT GDSC1; CCLE 4.1339 5.8577 2.3689 1.4256
HDLM-2 GDSC1 4.1354 6.0585 0.3812 0.3001
SUP-T1 GDSC1; CCLE 4.1944 8.9133 0.97 8.3133
EB2 GDSC1; CCLE 4.2425 12.8103 -0.9121 17.0932
U-698-M GDSC1 4.4456 15.6416 -3.6864 19.7819
RS4;11 GDSC1 4.5261 16.3471 -3.9709 20.6609
Ramos.2G6.4C10 GDSC1 4.678 13.9704 -2.7359 15.2628
OCI-AML-5 GDSC1; CCLE 4.7857 10.8483 0.4459 9.7952
BL-41 GDSC1; CCLE 4.7931 6.1262 2.5638 0.2645
NKM-1 GDSC1 5.0416 17.469 -4.1584 20.2184
RL GDSC1 5.2138 14.1563 -2.4862 12.9897
OCI-Ly10 CCLE 5.5339 7.4223 2.3821 0.3771
HH [Human lymphoma] GDSC1; CCLE 5.5411 7.4179 2.3864 0.3653
JM-1 CCLE 6.0075 7.5017 2.5246 0.0697
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 1.6301 3.262 0.3411 3.3081
TE-12 GDSC1 3.477 6.7257 -0.1572 3.1569
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.4748 6.6851 0.2869 0.3912
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-13 GDSC1 1.9396 3.8452 0.2633 3.1597
SJNB-14 GDSC1 1.9907 6.5724 -1.0098 12.2562
SK-N-BE(2)-M17 GDSC1 2.0606 3.9729 0.2768 2.8173
NB1 GDSC1 2.0623 3.8196 0.3461 2.3498
CHP-126 GDSC1 2.3673 4.0076 0.4251 1.3862
NB(TU)1 GDSC1 2.6853 4.5288 0.364 1.3202
GOTO GDSC1 2.7165 5.2057 0.0966 2.8107
SJNB-17 GDSC1 2.891 9.1991 -1.6507 13.8412
LA-N-6 GDSC1 2.9219 4.7302 0.3907 0.9503
IMR-5 GDSC1 3.0133 11.91 -2.8817 19.9499
SJNB-6 GDSC1 3.031 4.435 0.5439 0.326
IMR-32 CCLE 3.0778 4.4484 2.3396 3.3895
SK-N-DZ GDSC1; CCLE 3.1682 4.6044 2.3333 3.2149
KP-N-YS GDSC1 3.2227 7.9642 -0.8502 7.9993
SiMa GDSC1; CCLE 3.2234 6.3804 1.4921 7.6283
SJNB-5 GDSC1 3.2543 4.9382 0.4488 0.4927
CHP-212 CCLE 3.2609 5.3495 2.0349 4.6151
KP-N-SI9s CCLE 3.3246 7.059 1.2342 8.7776
Kelly GDSC1; CCLE 3.3439 4.707 2.4133 2.4186
NB69 GDSC1 3.3742 5.295 0.3656 0.6998
SK-N-SH CCLE 3.4018 5.4307 2.1011 3.9575
NH-12 GDSC1 3.4082 5.1967 0.415 0.5147
TGW GDSC1 3.529 4.9635 0.5407 0.1678
MHH-NB-11 GDSC1 3.5619 5.1661 0.4831 0.2691
SK-N-BE(2) CCLE 3.7113 5.8513 2.1147 3.2891
GI-ME-N GDSC1 3.7203 6.3609 0.1061 1.484
SJNB-7 GDSC1 3.7693 9.0053 -0.9981 7.7849
SJNB-10 GDSC1 3.8215 13.8634 -3.2591 19.5275
SK-N-AS CCLE 3.9362 6.8694 1.7789 4.6167
KP-N-RT-BM-1 GDSC1 4.215 6.7417 0.1683 0.8512
KP-N-YN GDSC1 4.4467 16.6586 -4.1762 21.5632
SK-N-FI GDSC1; CCLE 5.0902 6.6268 2.4979 0.2951
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CCLE 4.1691 7.0107 1.8651 3.776
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES6 GDSC1 0.8844 2.349 0.2269 6.5292
ES1 GDSC1 1.003 10.6702 -3.8326 29.8357
EW-22 GDSC1 1.0595 18.1121 -7.5065 37.472
EW-16 GDSC1 1.2798 2.8313 0.3058 4.5416
NOS-1 [Human HNSCC] GDSC1 1.297 6.8083 -1.6605 18.8046
MHH-ES-1 CCLE 1.3095 5.3532 0.2297 19.7553
EW-18 GDSC1 1.6523 3.5012 0.2424 3.9843
HOS CCLE 2.2325 4.1473 1.7063 9.187
ES5 GDSC1 2.2467 4.7967 0.0126 4.2574
ES8 GDSC1 2.3276 4.18 0.3326 1.9827
SK-PN-DW GDSC1 2.9683 8.6931 -1.3557 11.8405
ES7 GDSC1 2.9892 5.7131 0.022 2.8331
EW-24 GDSC1 3.0704 4.2273 0.6299 0.1277
H-EMC-SS GDSC1 3.3659 6.6488 -0.1816 3.4689
EW-13 GDSC1 3.3804 5.3082 0.3632 0.7043
ES4 GDSC1 3.5446 16.8586 -4.9215 26.0087
SJSA-1 GDSC1; CCLE 3.592 5.5719 2.1677 3.2322
CAL-78 CCLE 3.6063 5.8944 2.0217 3.9693
EW-12 GDSC1 3.763 5.4 0.4745 0.2255
A-673 CCLE 3.8471 5.8194 2.2182 2.534
SK-ES-1 GDSC1; CCLE 3.8662 5.9211 2.1828 2.6798
EW-1 GDSC1 4.0388 5.9029 0.4002 0.2911
U2OS CCLE 4.0726 6.6194 1.987 3.3233
MG-63 CCLE 4.5995 7.1235 2.0692 2.1893
SaOS-2 CCLE 4.7164 6.4364 2.4149 0.7115
EW-3 GDSC1 4.8608 17.8641 -4.4717 21.6607
EW-11 GDSC1 4.8717 15.3119 -3.2437 17.0773
TC-71 GDSC1; CCLE 5.3572 7.0837 2.436 0.3279
SW1353 CCLE 5.47 7.4143 2.3599 0.4524
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MRK-nu-1 GDSC1 1.8437 6.019 -0.8458 11.5467
HDQ-P1 CCLE 2.0905 5.9719 0.7015 14.8841
Evsa-T GDSC1 2.5303 4.0709 0.4756 0.9363
CAL-148 GDSC1 2.6464 4.1902 0.48 0.8052
ZR-75-1 CCLE 2.7168 6.8831 0.8177 12.5086
EFM-19 CCLE 2.7247 4.6973 1.9123 6.6166
DU4475 GDSC1 2.7493 4.6397 0.3491 1.3227
HCC1599 GDSC1 2.8212 4.4855 0.4415 0.8188
HCC1500 GDSC1 2.9886 9.4772 -1.7176 13.9787
MDA-MB-468 CCLE 3.0367 4.5395 2.2606 3.9163
BT-474 GDSC1; CCLE 3.1041 5.4175 1.8768 5.8317
CAMA-1 CCLE 3.2913 6.2663 1.6028 6.8745
ZR-75-30 CCLE 3.292 5.2468 2.1097 4.1444
HCC1395 CCLE 3.328 5.0981 2.2101 3.5299
HCC1569 CCLE 3.3789 7.15 1.2317 8.6663
HCC2157 GDSC1 3.3793 4.9749 0.4831 0.3364
MFM-223 GDSC1 3.3802 5.013 0.47 0.37
OCUB-M GDSC1 3.4018 5.2346 0.3987 0.5697
HCC2218 GDSC1 3.4314 5.1791 0.4302 0.457
BT-20 CCLE 3.6705 18.3875 -4.1424 28.5748
SK-BR-3 CCLE 3.6835 6.3805 1.84 4.7745
BT-549 CCLE 3.7066 5.9089 2.084 3.4564
T-47D CCLE 3.7785 5.9874 2.0947 3.2731
MDA-MB-453 CCLE 3.8145 6.1204 2.0552 3.4119
MDA-MB-175-VII CCLE 3.8178 6.0113 2.1092 3.1308
HCC1806 CCLE 3.9292 5.9412 2.2127 2.4326
HCC1954 CCLE 4.0239 6.9517 1.7985 4.3592
HCC1187 GDSC1; CCLE 4.1499 10.439 0.1899 12.3141
HCC70 CCLE 4.1825 7.8426 1.4792 5.7149
HMC-1-8 CCLE 4.3648 5.6923 2.5505 0.5155
MCF-7 CCLE 4.4209 6.7748 2.1239 2.1662
MDA-MB-415 CCLE 4.5269 6.4651 2.3137 1.2353
UACC-812 GDSC1; CCLE 4.9318 10.9802 0.4824 9.348
AU565 CCLE 4.9895 7.5484 2.0918 1.6654
Hs 578T CCLE 5.131 7.3952 2.2225 1.0538
MDA-MB-436 CCLE 5.5527 7.5537 2.3416 0.4604
MDA-MB-157 CCLE 5.5711 7.5107 2.3645 0.4011
Hs 739.T CCLE 6.0215 8.2057 2.2874 0.3991
COLO 824 GDSC1 6.0624 18.5851 -4.0165 17.6878
CAL-85-1 CCLE 6.212 8.2816 2.3317 0.2629
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KINGS-1 GDSC1 -1.263 12.2004 -6.5823 43.1954
LN-18 CCLE 1.5695 2.7455 1.5003 12.592
Becker GDSC1 1.9956 6.5756 -1.0079 12.2283
KNS-81-FD GDSC1 2.3464 6.5586 -0.7531 9.461
D-502MG GDSC1 2.4253 7.82 -1.3076 12.9865
D283 Med GDSC1 2.5338 3.8901 0.5469 0.6176
KNS-60 CCLE 2.6039 7.1062 0.6081 13.9086
42-MG-BA CCLE 2.718 4.3108 2.0969 5.6433
GaMG CCLE 2.751 4.4711 2.0478 5.8145
AM-38 GDSC1 2.7538 4.9958 0.2051 2.1024
NMC-G1 GDSC1 2.7964 4.2185 0.5315 0.4891
8-MG-BA GDSC1; CCLE 3.0429 6.8585 1.1063 10.1369
D-263MG GDSC1 3.094 4.6657 0.4853 0.4664
GI-1 GDSC1; CCLE 3.1625 6.3064 1.4802 7.8365
KS-1 [Human Krukenberg tumour] GDSC1 3.1936 11.0026 -2.3122 16.7118
Onda 11 GDSC1 3.2334 5.118 0.3743 0.7651
DK-MG CCLE 3.2865 5.4114 2.0239 4.6176
D-247MG GDSC1 3.3398 5.5215 0.2658 1.1232
H4 CCLE 3.3573 5.595 1.987 4.6617
KNS-81 CCLE 3.3745 6.0848 1.7576 5.8554
SNB-75 GDSC1 3.5456 16.404 -4.6972 25.3419
Onda 10 GDSC1 3.5575 5.3218 0.427 0.407
KNS-42 GDSC1; CCLE 3.6004 5.0236 2.4341 1.855
SF539 GDSC1 3.6264 12.4047 -2.6897 17.4739
SF295 CCLE 3.6698 7.8819 1.0923 8.7587
SF268 GDSC1 3.6821 5.3913 0.4486 0.3044
KALS-1 GDSC1; CCLE 4.0493 7.4023 1.6001 5.3347
Hs 683 CCLE 4.1453 6.6353 2.025 3.0208
D-336MG GDSC1 4.2038 6.4175 0.2809 0.513
GMS-10 CCLE 4.4226 9.152 1.0137 7.6535
MOG-G-CCM CCLE 4.4832 7.1066 2.0114 2.6006
M059J CCLE 4.6191 7.4349 1.9423 2.7395
DBTRG-05MG CCLE 4.6308 7.0592 2.1143 1.9545
YKG-1 CCLE 4.6482 6.5262 2.3476 0.9964
1321N1 CCLE 4.8746 8.2354 1.7303 3.3795
LN-229 CCLE 5.0129 7.107 2.2834 0.9348
Daoy CCLE 5.0819 7.0906 2.3206 0.7666
CAS-1 GDSC1; CCLE 5.1583 6.7503 2.4796 0.3087
SW1088 CCLE 5.1734 13.1984 -0.4211 13.0718
ONS-76 GDSC1; CCLE 5.2634 6.8353 2.4891 0.2544
A-172 CCLE 5.2683 6.9618 2.4457 0.34
U-118MG CCLE 5.2793 6.8821 2.4785 0.2695
T98G CCLE 5.322 7.0589 2.4314 0.3506
SF126 GDSC1; CCLE 5.3397 6.7576 2.5442 0.1457
GB-1 GDSC1; CCLE 5.4511 7.0804 2.4725 0.2295
U-87MG ATCC GDSC1; CCLE 6.7715 14.3413 0.079 8.2055
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.7354 7.1684 -1.4948 16.2783
TGBC1TKB GDSC1 2.2628 5.1843 -0.1568 5.4201
TGBC24TKB GDSC1 3.2152 5.1594 0.3512 0.8696
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 CCLE 0.4274 5.4193 -0.7027 27.1876
MFE-319 CCLE 2.1063 4.3829 1.4722 10.8084
HEC-6 CCLE 2.559 4.6047 1.8059 7.658
JHUEM-2 CCLE 3.025 4.8704 2.0856 4.893
AN3-CA CCLE 3.0269 5.2586 1.893 5.9314
HEC-151 CCLE 3.486 8.1723 0.8069 10.6664
MFE-296 CCLE 3.5479 7.4116 1.2325 8.2829
HEC-265 CCLE 3.5494 8.8518 0.5184 12.0084
MFE-280 CCLE 3.9137 6.4868 1.9466 3.7944
KLE GDSC1; CCLE 4.1372 6.9223 1.8862 3.7226
EN CCLE 4.2833 6.2755 2.2676 1.6928
HEC-251 CCLE 4.4041 9.086 1.0327 7.5913
HEC-59 CCLE 4.7122 8.6781 1.4294 5.0647
HEC-1-B CCLE 5.1813 6.7495 2.4887 0.2818
TEN CCLE 5.2228 7.3274 2.2902 0.7706
RL95-2 GDSC1; CCLE 5.2353 6.8441 2.4754 0.2901
HEC-1-A CCLE 5.3646 7.2923 2.3627 0.4924
EFE-184 CCLE 5.3952 6.8934 2.5173 0.1721
Ishikawa (Heraklio) 02 ER- CCLE 2.4155 5.2331 1.3655 10.4249
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1 -2.6473 -0.2659 -2.7198 45.8099
A-498 GDSC1 1.7941 9.7322 -2.7232 22.816
RCC10RGB GDSC1 2.4356 4.3815 0.3027 1.9967
VMRC-RCW CCLE 2.4468 5.593 1.2179 11.1218
BB65-RCC GDSC1 2.5619 4.4099 0.3538 1.5251
769-P CCLE 2.727 3.81 2.3499 4.2665
A-704 GDSC1 2.9426 6.8427 -0.505 6.3247
786-O CCLE 3.2477 5.3501 2.0245 4.701
KMRC-1 CCLE 3.4341 6.0785 1.8058 5.4673
LB1047-RCC GDSC1 3.4359 6.0185 0.1135 1.74
KMRC-2 CCLE 3.5904 8.1228 0.9124 9.8783
HA7-RCC GDSC1 3.6385 5.6907 0.3253 0.6726
OS-RC-2 GDSC1 3.6589 5.4618 0.4153 0.3939
ACHN CCLE 3.7435 6.3214 1.9107 4.2886
LB996-RCC GDSC1 3.8043 5.8585 0.329 0.5679
VMRC-RCZ CCLE 4.116 6.0711 2.2646 1.9179
TK-10 GDSC1 4.1444 6.2502 0.3179 0.4419
BFTC-909 CCLE 4.1907 6.1076 2.2905 1.7042
RXF 393L GDSC1 4.7074 7.1657 0.2043 0.4994
Caki-2 CCLE 5.4621 7.1092 2.4665 0.2367
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC1 1.2194 3.1886 0.0828 6.4761
LS513 GDSC1; CCLE 2.3605 3.4463 2.1445 6.5201
NCI-H716 GDSC1 2.5589 4.8965 0.1463 2.7624
SW1417 CCLE 2.9605 8.0189 0.4575 13.7477
MDST8 GDSC1 3.098 4.3916 0.5836 0.2056
COLO205 CCLE 3.1198 5.3361 1.9303 5.5051
LS411N GDSC1; CCLE 3.2457 6.6463 1.3774 8.1936
HT-29 CCLE 3.3473 5.6325 1.9608 4.8238
NCI-H747 GDSC1; CCLE 3.3583 5.0603 2.251 3.249
LS1034 GDSC1 3.401 4.6692 0.5954 0.1117
HCC-56 CCLE 3.4158 5.9616 1.8499 5.2705
SNU-C1 GDSC1 3.4462 5.2604 0.4066 0.5199
CW-2 GDSC1 3.4923 12.3089 -2.7362 18.0283
COLO 320HSR GDSC1 3.5922 5.4436 0.3967 0.4749
RKO GDSC1; CCLE 3.6081 5.8933 2.0235 3.9562
SW403 CCLE 3.6726 5.7161 2.1533 3.1596
COLO 320 CCLE 3.7406 6.3565 1.8917 4.3938
CL-11 GDSC1 3.7485 5.8459 0.3119 0.652
SK-CO-1 CCLE 3.9232 6.4053 1.9916 3.5486
COLO 678 CCLE 3.9257 6.0046 2.1812 2.5929
CCK-81 CCLE 3.9568 9.2078 0.653 10.421
SW620 CCLE 4.1812 6.7145 2.0105 3.0372
HCT 116 CCLE 4.187 6.1585 2.2659 1.8198
SNU-C2B GDSC1; CCLE 4.2667 6.3004 2.2476 1.8021
T84 CCLE 4.281 6.5212 2.1576 2.1934
HCT 15 CCLE 4.3588 7.3083 1.8454 3.5728
LS123 GDSC1; CCLE 4.6199 6.5671 2.3172 1.1346
SNU-C2A CCLE 4.7865 8.4149 1.5968 4.1357
COLO201 CCLE 4.8725 6.2375 2.5543 0.2558
SW48 CCLE 5.3907 7.171 2.4175 0.3548
C2BBe1 GDSC1; CCLE 5.6619 7.7061 2.3289 0.4446
SW480 CCLE 6.4099 8.4194 2.3551 0.1865
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.1506 4.7346 0.4823 0.445
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-7 CCLE 1.9053 4.4416 1.2431 12.6465
SNU-387 CCLE 2.4611 6.3302 0.8669 12.9453
SNU-423 CCLE 2.8215 6.6005 1.049 11.0056
SNU-475 CCLE 2.8652 4.1661 2.3012 4.1358
SNU-182 CCLE 2.9291 5.4242 1.7284 7.0686
JHH-4 CCLE 2.9409 5.126 1.8874 6.1773
Hep-G2 CCLE 3.3563 5.2789 2.1422 3.8333
Hep-G2/C3A CCLE 3.3695 6.743 1.4268 7.6433
HuH-1 CCLE 3.5078 5.0733 2.3499 2.4414
JHH-6 CCLE 3.538 7.2369 1.3115 7.8845
Hep 3B2.1-7 CCLE 3.7631 7.4564 1.3713 7.0894
SNU-398 CCLE 3.8907 7.4042 1.4888 6.2147
HLF CCLE 3.9298 6.0201 2.1766 2.6094
PLC/PRF/5 CCLE 4.0107 7.1908 1.6753 5.0164
SK-HEP-1 CCLE 4.2047 6.2291 2.2445 1.8943
SNU-449 CCLE 4.316 6.9666 1.9766 3.0002
JHH-2 CCLE 4.511 6.2179 2.4079 0.8915
JHH-5 CCLE 4.7547 8.2348 1.6601 3.879
HLE CCLE 5.486 7.9715 2.1548 1.0231
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 139 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MES-1 CCLE 0.3461 2.6705 0.1866 23.5012
EBC-1 CCLE 0.9003 5.7123 -0.3461 23.8973
DV-90 CCLE 0.9244 15.2607 -4.9357 36.8257
CAL-12T CCLE 1.1744 8.3973 -1.3384 27.0931
LXF 289 GDSC1 1.474 3.4423 0.1478 5.1854
Hs 229.T CCLE 1.8581 7.2942 -0.1598 19.8894
NCI-H526 GDSC1 2.0065 3.5527 0.4327 1.8867
NCI-H2172 CCLE 2.0276 3.3002 1.8439 9.2022
NCI-H345 GDSC1 2.0545 3.0601 0.6604 0.5447
MOR/CPR CCLE 2.1393 7.8828 -0.1912 19.2
LC-2/ad GDSC1 2.1563 4.262 0.2021 3.1347
NCI-H720 GDSC1 2.2375 8.77 -1.9081 17.1977
NCI-H510A GDSC1 2.2398 4.5681 0.1126 3.5782
NCI-H1836 GDSC1 2.3533 7.3064 -1.109 11.883
NCI-H2141 GDSC1 2.4175 4.0238 0.4425 1.2281
COR-L95 GDSC1 2.5142 4.6488 0.2294 2.3185
NCI-H2023 CCLE 2.5348 5.0065 1.5868 8.899
PC-14 CCLE 2.5865 5.9948 1.1454 11.1185
NCI-H2196 GDSC1 2.6547 4.8542 0.2146 2.1914
COLO 677 CCLE 2.6807 5.2196 1.614 8.3437
NCI-H1436 GDSC1 2.6908 4.6706 0.309 1.6043
NCI-H2081 GDSC1 2.695 4.1543 0.5142 0.6229
Sq-1 CCLE 2.6974 8.7237 -0.1178 17.2885
VMRC-LCD CCLE 2.7056 5.1187 1.6864 7.8857
HCC33 GDSC1 2.7175 4.1657 0.5192 0.5869
NCI-H82 GDSC1 2.765 4.2737 0.4983 0.6327
SK-LU-1 CCLE 2.7753 6.2685 1.175 10.4522
HCC15 CCLE 2.8059 4.2729 2.1954 4.8682
NCI-H1703 CCLE 2.8386 6.8649 0.9315 11.5865
HCC44 CCLE 2.9148 8.4933 0.182 15.2542
NCI-H748 GDSC1 2.9164 8.8072 -1.4451 12.5283
NCI-H524 GDSC1 2.93 8.752 -1.4095 12.2731
LCLC-103H CCLE 2.9304 5.1835 1.8497 6.4082
NCI-H647 CCLE 2.9595 6.0993 1.4165 8.6779
NCI-H69 GDSC1 3.0082 5.0369 0.309 1.2416
DMS 79 GDSC1 3.0149 4.9315 0.3531 1.0318
GLC-82 CCLE 3.0305 6.5587 1.246 9.4192
NCI-H1581 GDSC1; CCLE 3.0333 4.4692 2.2929 3.7492
NCI-H2009 CCLE 3.0411 5.8503 1.6089 7.4349
NCI-H1944 CCLE 3.045 5.9317 1.5715 7.6274
NCI-H2135 GDSC1 3.0682 4.5392 0.5209 0.3727
NCI-H847 GDSC1 3.0724 4.6673 0.4763 0.5078
DMS 114 GDSC1; CCLE 3.1346 5.0503 2.0848 4.6343
NCI-H1155 GDSC1; CCLE 3.15 5.2896 1.9777 5.1773
SBC-1 GDSC1 3.17 4.8307 0.455 0.5205
Ms-1 GDSC1 3.1738 4.6057 0.5368 0.2849
NCI-H1304 GDSC1 3.1863 4.8198 0.4653 0.4784
NCI-H211 GDSC1; CCLE 3.1947 5.2154 2.0501 4.6827
NCI-H1299 GDSC1; CCLE 3.1972 5.0428 2.1379 4.2033
NCI-H2087 CCLE 3.1996 5.0006 2.1608 4.0742
NCI-H661 CCLE 3.2013 6.5634 1.3832 8.267
Lu-165 GDSC1 3.2662 4.868 0.4786 0.3981
HCC78 CCLE 3.2792 7.3402 1.058 9.8234
Calu-6 GDSC1; CCLE 3.2799 4.6411 2.3994 2.6209
NCI-H2122 CCLE 3.2986 4.9223 2.2749 3.2457
NCI-H1876 GDSC1 3.3204 5.0335 0.44 0.4846
NCI-H1341 CCLE 3.3227 5.6586 1.9291 5.0476
COR-L88 GDSC1 3.3252 8.3811 -0.9798 8.6077
HCC827 CCLE 3.3359 7.072 1.2367 8.738
SW1271 CCLE 3.3376 7.5372 1.0062 9.961
KNS-62 CCLE 3.3525 8.669 0.4537 12.7997
Lu-139 GDSC1 3.3527 5.2797 0.3626 0.725
NCI-H650 CCLE 3.3563 7.9169 0.8318 10.8368
NCI-H2085 CCLE 3.402 5.9974 1.8217 5.4511
T3M-10 CCLE 3.4169 6.5385 1.565 6.7956
COLO 699 CCLE 3.4172 6.0434 1.8104 5.479
NCI-H460 CCLE 3.4631 5.0798 2.3162 2.6992
NCI-H1693 CCLE 3.4669 6.232 1.7547 5.6707
NCI-H209 GDSC1 3.5004 5.4335 0.3649 0.6232
SW1573 CCLE 3.5016 6.4694 1.6635 6.0841
LC-1/sq-SF CCLE 3.507 5.512 2.1373 3.5537
Lu-65 GDSC1 3.5254 5.608 0.3106 0.7974
NCI-H322M GDSC1 3.5306 6.2606 0.0602 1.9013
COR-L105 CCLE 3.5535 6.3813 1.7455 5.5374
NCI-H2444 CCLE 3.5598 7.9829 0.9583 9.706
NCI-H1373 CCLE 3.5801 5.1504 2.3613 2.2558
CPC-N GDSC1 3.5918 5.3142 0.4424 0.3527
NCI-H1963 GDSC1 3.5992 5.4239 0.4064 0.4442
NCI-H1048 CCLE 3.6066 5.5909 2.1686 3.2006
NCI-H2171 GDSC1 3.6073 15.0198 -3.9736 22.8112
LB647-SCLC GDSC1 3.6485 5.3376 0.455 0.3018
SBC-5 CCLE 3.6496 7.3602 1.3347 7.5203
NCI-H1869 GDSC1; CCLE 3.6906 6.7596 1.6601 5.7101
COLO 668 GDSC1 3.7041 5.358 0.4679 0.2556
EKVX GDSC1 3.7174 6.6745 -0.0194 2.0914
NCI-H1915 CCLE 3.7356 7.4708 1.3441 7.2899
NCI-H446 GDSC1 3.7384 5.282 0.5059 0.1764
Calu-3 CCLE 3.7633 6.5634 1.8074 4.7916
Lu-99 CCLE 3.8117 5.7659 2.2208 2.5783
IA-LM GDSC1; CCLE 3.8128 5.641 2.2797 2.2834
NCI-H1568 CCLE 3.838 5.9815 2.1364 2.9588
HOP-62 GDSC1 3.8461 5.5603 0.4491 0.2507
NCI-H64 GDSC1 3.8867 12.0866 -2.3615 15.2411
Calu-1 CCLE 3.8894 7.8832 1.2541 7.448
NCI-H23 GDSC1; CCLE 3.9323 6.9506 1.7373 4.8394
IST-SL1 GDSC1 3.9416 5.6722 0.4447 0.2323
NCI-H2286 CCLE 3.9424 6.7019 1.8633 4.1711
NCI-H1770 GDSC1 3.9573 15.7249 -4.0671 22.3017
NCI-H1838 GDSC1 4.0331 6.2373 0.2806 0.5953
NCI-H1355 GDSC1; CCLE 4.094 6.2762 2.1589 2.4473
HARA [Human squamous cell lung carcinoma] CCLE 4.1257 7.4079 1.6489 4.9457
NCI-H1339 CCLE 4.1492 8.0281 1.3673 6.3528
NCI-H358 CCLE 4.1678 6.4751 2.1122 2.5644
NCI-H1573 CCLE 4.1784 7.4891 1.6452 4.8718
NCI-H1651 CCLE 4.1846 7.9534 1.4275 5.977
NCI-H1092 GDSC1; CCLE 4.3152 6.3517 2.2517 1.7249
NCI-H1650 GDSC1; CCLE 4.324 7.2208 1.8644 3.5335
NCI-H1563 CCLE 4.339 6.4954 2.2017 1.9181
HCC4006 CCLE 4.3567 6.9833 1.9933 2.8612
SW900 CCLE 4.4568 6.7765 2.1431 2.0351
HCC2935 CCLE 4.4635 6.4954 2.2686 1.484
NCI-H226 GDSC1; CCLE 4.4735 5.7184 2.5866 0.3484
LUDLU-1 CCLE 4.5749 6.301 2.4043 0.8524
RERF-LC-A1 CCLE 4.622 6.4948 2.3479 1.0175
NCI-H522 CCLE 4.6252 6.4511 2.3672 0.9442
IST-SL2 GDSC1 4.6398 17.0574 -4.235 21.3408
NCI-H1666 GDSC1; CCLE 4.706 7.4648 1.9779 2.4662
NCI-H2170 CCLE 4.8021 6.7502 2.3292 0.9375
NCI-H727 CCLE 4.8025 8.3134 1.6527 3.8451
NCI-H520 CCLE 4.8686 7.0591 2.2353 1.2224
COR-L23 CCLE 4.9372 6.727 2.3985 0.6203
NCI-H2030 CCLE 4.9461 7.2297 2.2026 1.2766
NCI-H810 CCLE 4.9991 6.7889 2.4011 0.5767
NCI-H1975 GDSC1; CCLE 5.0856 6.7613 2.447 0.412
LOU-NH91 CCLE 5.104 6.8416 2.4247 0.459
NCI-H1694 GDSC1; CCLE 5.1124 6.5466 2.5349 0.2162
NCI-H1792 CCLE 5.2013 7.2045 2.3282 0.6706
SHP-77 GDSC1; CCLE 5.223 6.7809 2.4933 0.2592
NCI-H3255 CCLE 5.2657 7.507 2.2391 0.9022
A-549 CCLE 5.4889 7.3024 2.4079 0.3393
NCI-H1793 CCLE 5.6757 7.3526 2.4596 0.1939
NCI-H322 CCLE 5.7185 7.2025 2.5259 0.1027
NCI-H2228 CCLE 5.7359 8.1084 2.2095 0.7082
NCI-H1184 CCLE 5.9251 7.7687 2.4057 0.2173
Lu-134-A GDSC1 6.0702 20.3065 -4.8251 20.3822
NCI-H441 CCLE 6.072 7.822 2.4396 0.143
NCI-H1648 GDSC1; CCLE 6.3693 8.6355 2.2656 0.3314
NCI-H187 GDSC1 7.3885 22.0406 -4.7925 17.95
NCI-H128 GDSC1 8.1364 24.0684 -5.2682 18.186
⏷ Show the Full List of 139 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.8062 5.563 0.4339 0.2945
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CCLE 0.7131 4.4665 -0.007 22.9949
TE-15 GDSC1; CCLE 2.2571 8.8389 -0.5595 20.5522
KYSE-70 CCLE 2.7633 4.4573 2.0658 5.6839
KYSE-410 CCLE 2.8988 6.7974 1.0163 10.9805
KYSE-180 CCLE 2.9976 5.2222 1.8869 6.0371
KYSE-510 CCLE 3.046 4.6207 2.2277 4.072
TE-1 GDSC1; CCLE 3.1926 5.7701 1.7719 6.19
EC-GI-10 GDSC1 3.1954 5.7323 0.1165 2.0068
OE33 CCLE 3.2942 7.5753 0.9527 10.3467
OE21 CCLE 3.326 5.5528 1.9841 4.7451
TE-5 GDSC1; CCLE 3.3482 5.2432 2.1537 3.7888
KYSE-450 CCLE 3.4421 5.4188 2.1364 3.6878
TE-8 GDSC1 3.6391 5.7679 0.2972 0.7695
TE-6 GDSC1 3.6466 5.3384 0.454 0.3046
TE-10 GDSC1 4.0976 14.6232 -3.4348 19.5913
KYSE-30 CCLE 4.2396 6.4746 2.1547 2.2626
KYSE-520 CCLE 4.9775 7.1097 2.2661 1.021
KYSE-150 CCLE 5.0225 6.3303 2.5776 0.1682
TE-9 GDSC1; CCLE 5.3356 6.6168 2.5906 0.0904
TE-11 GDSC1; CCLE 5.524 7.3352 2.4096 0.3237
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kuramochi GDSC1; CCLE 2.6774 4.2155 2.1062 5.7103
TOV-21G CCLE 3.0264 5.4043 1.8198 6.3294
OVCAR-8 CCLE 3.0521 4.3573 2.3643 3.3172
OC 314 CCLE 3.0951 4.2529 2.4509 2.7471
JHOS-4 CCLE 3.1876 6.1175 1.5947 7.1593
ES-2 GDSC1; CCLE 3.5397 9.7973 0.04 14.4085
TYK-nu CCLE 3.8415 6.8341 1.7309 5.0426
SK-OV-3 CCLE 3.9905 5.866 2.2841 1.9981
ONCO-DG-1 CCLE 4.0655 6.1569 2.1963 2.3094
MCAS CCLE 4.0897 6.4057 2.0969 2.7544
OC 315 CCLE 4.0964 5.7324 2.403 1.3205
A2780 CCLE 4.237 6.2879 2.2366 1.889
JHOS-2 CCLE 4.3094 7.7879 1.5896 4.9285
FU-OV-1 CCLE 4.3355 6.4948 2.2 1.9299
DOV13 CCLE 4.4656 6.3985 2.3108 1.3079
COV318 CCLE 4.4908 5.2493 2.7584 0.0392
TOV-112D CCLE 4.5022 7.4111 1.885 3.1694
OV-90 CCLE 4.8472 6.9131 2.2846 1.0595
HEY A8 CCLE 4.859 6.5286 2.4411 0.542
OVCAR-4 GDSC1; CCLE 4.9371 6.9751 2.3013 0.9304
OVCAR-3 CCLE 5.0207 6.7307 2.4321 0.4804
EFO-21 CCLE 5.0662 6.6469 2.4813 0.34
OVTOKO CCLE 5.1029 7.836 2.0281 1.8079
OVSAHO CCLE 5.2246 6.8345 2.4748 0.2951
OVMANA CCLE 5.2511 6.4289 2.6244 0.0686
OC 316 CCLE 5.421 7.2185 2.412 0.3551
EFO-27 CCLE 5.6807 7.6642 2.3514 0.3881
COV504 CCLE 5.6875 8.5367 2.022 1.32
IGROV-1 CCLE 6.0463 8.3912 2.2299 0.5132
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAF-II CCLE 1.8965 6.0698 0.4705 16.6608
KCI-MOH1 CCLE 2.1857 4.7101 1.3983 10.9421
BxPC-3 CCLE 2.6833 6.7087 0.8755 12.2924
QGP-1 CCLE 2.9035 5.7576 1.54 8.1527
HPAC CCLE 2.9308 7.1645 0.8598 11.7295
PaTu 8902 CCLE 3.0549 5.8806 1.6052 7.421
PSN1 GDSC1; CCLE 3.0952 5.2307 1.963 5.3866
AsPC-1 CCLE 3.1894 4.9127 2.1966 3.9045
SUIT-2 CCLE 3.1924 6.0672 1.6236 6.9916
KP-4 CCLE 3.3228 6.9984 1.263 8.6275
HuP-T4 CCLE 3.4011 7.4724 1.0887 9.3768
Capan-2 CCLE 3.5858 6.0225 1.9448 4.4144
SU.86.86 CCLE 3.7298 6.3838 1.8709 4.5228
Panc 04.03 CCLE 3.7977 7.4193 1.4147 6.7896
L3.3 CCLE 3.9119 5.6919 2.3167 1.955
HuP-T3 CCLE 4.0051 7.4733 1.5355 5.7515
MZ-PC-1 GDSC1 4.1485 6.2959 0.3033 0.4777
Panc 02.03 CCLE 4.5621 7.6336 1.8193 3.3966
PL45 CCLE 4.8846 7.1542 2.2039 1.3266
MIA PaCa-2 CCLE 4.89 6.5257 2.4552 0.4858
SW1990 CCLE 4.9257 7.2947 2.1659 1.435
PK-59 CCLE 4.9468 7.4223 2.1232 1.582
Panc 03.27 CCLE 5.0831 6.6831 2.4747 0.4067
KP-1N CCLE 5.0875 7.2993 2.2409 1.0237
KP-2 CCLE 5.1768 6.8425 2.4534 0.3586
KP-3 CCLE 5.3212 7.8763 2.1175 1.2723
Panc 10.05 CCLE 5.368 7.3272 2.3512 0.5198
Hs 766T CCLE 5.3792 7.0743 2.4478 0.2965
PK-45H CCLE 5.4028 7.6721 2.2349 0.8264
PK-1 CCLE 6.2259 8.476 2.2685 0.369
KP-1NL CCLE 7.2084 9.8321 2.1549 0.2978
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1; CCLE 3.4979 5.6326 2.0721 3.9164
MSTO-211H GDSC1; CCLE 3.5888 5.5466 2.1777 3.1863
NCI-H28 CCLE 4.0257 6.5624 1.9839 3.4155
NCI-H2452 CCLE 4.1536 6.8396 1.9353 3.4507
MPP 89 GDSC1; CCLE 4.7607 6.647 2.3514 0.8921
NCI-H2052 CCLE 5.2416 7.176 2.3559 0.5705
IST-Mes2 CCLE 5.3934 7.5426 2.2806 0.6973
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 2.6557 4.6688 0.2927 1.7402
LNCaP clone FGC GDSC1 3.4453 13.1115 -3.1587 20.0369
22Rv1 CCLE 3.5642 6.7232 1.5852 6.3693
PC-3 CCLE 5.5939 7.6422 2.3254 0.4808
DU145 CCLE 5.7394 8.0097 2.248 0.6051
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; CCLE 3.5368 5.4352 2.1955 3.1907
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A101D GDSC1 1.006 1.8209 0.5946 3.1758
LB2518-MEL GDSC1 1.7486 4.6597 -0.2497 7.4306
IST-MEL1 GDSC1 2.1304 4.2166 0.2075 3.1501
MMAc-SF GDSC1 2.3708 3.8292 0.4992 0.9902
CP67-MEL GDSC1 2.5589 5.2045 0.0108 3.639
WM983B CCLE 2.704 4.9573 1.7649 7.4672
LB373-MEL-D GDSC1 2.7587 3.8888 0.6351 0.2071
G-361 CCLE 2.781 4.3815 2.1192 5.347
SK-MEL-1 GDSC1 2.8124 4.2461 0.5277 0.4922
WM793 CCLE 2.8764 5.5599 1.6156 7.8137
UACC-62 CCLE 2.8808 5.0652 1.8665 6.4452
GAK GDSC1 2.9594 4.2641 0.5776 0.2689
K029AX CCLE 2.9705 4.9614 1.9946 5.5218
Hs 936.T CCLE 3.0368 4.7191 2.171 4.4014
A-375 CCLE 3.0466 4.4422 2.3174 3.5842
MZ-MEL-7 GDSC1 3.074 4.4308 0.5613 0.2639
CP66-MEL GDSC1 3.0922 4.7706 0.4462 0.598
Hs 938.T CCLE 3.1022 7.4368 0.8662 11.2668
COLO 679 CCLE 3.1445 4.8772 2.179 4.1019
SK-MEL-31 CCLE 3.2073 4.7988 2.2669 3.4854
LOX-IMVI GDSC1; CCLE 3.2147 4.9439 2.2007 3.8257
HMCB CCLE 3.227 4.912 2.226 3.6624
MDA-MB-435S CCLE 3.3096 4.6238 2.4294 2.4016
UACC-257 GDSC1; CCLE 3.3233 4.836 2.3355 2.8717
A2058 CCLE 3.3293 4.8326 2.3415 2.8275
Hs 944.T CCLE 3.3708 5.3324 2.1266 3.8865
COLO 800 GDSC1 3.4052 12.714 -2.9937 19.4221
WM115 CCLE 3.4418 6.5073 1.5996 6.5556
COLO 829 GDSC1 3.5068 15.6568 -4.3587 24.3702
HT-144 GDSC1; CCLE 3.5177 5.2102 2.2909 2.7292
WM1799 CCLE 3.541 5.9167 1.9643 4.4008
SK-MEL-5 CCLE 3.552 6.2484 1.8097 5.1986
COLO 741 CCLE 3.5629 7.5336 1.1835 8.5104
SH-4 GDSC1 3.5731 5.7426 0.2798 0.8789
SK-MEL-24 CCLE 3.674 5.1475 2.4224 1.7966
WM88 CCLE 3.6778 5.6456 2.1905 2.959
DJM-1 GDSC1 3.7411 5.7052 0.3598 0.5087
Hs 294T CCLE 3.7549 6.0727 2.0381 3.6061
Hs 852.T CCLE 3.767 7.1922 1.5036 6.3829
MZ-MEL-2 GDSC1 3.7878 5.7429 0.3641 0.4744
MeWo CCLE 3.8861 6.4172 1.9615 3.7667
A-388 GDSC1 3.8913 5.9622 0.325 0.5358
CHL-1 CCLE 3.8949 6.6365 1.8626 4.2595
RVH-421 CCLE 3.9415 6.5464 1.9367 3.7967
Hs 895.T CCLE 3.9958 6.0483 2.2041 2.374
WT2-iPS CCLE 4.0044 5.6987 2.3672 1.5925
Mel Ho CCLE 4.0417 5.6703 2.4005 1.3962
IGR-39 CCLE 4.4499 5.9181 2.4997 0.6206
SK-MEL-2 GDSC1; CCLE 4.5305 5.9233 2.5329 0.4662
IGR-37 CCLE 4.5561 5.672 2.6362 0.1991
RPMI-7951 CCLE 4.6008 11.8023 -0.1488 12.9775
IPC-298 CCLE 4.8731 6.8206 2.3336 0.8685
SK-MEL-30 CCLE 4.9362 6.3631 2.5336 0.2759
WM266-4 CCLE 5.0209 6.1396 2.6423 0.0818
SF8657 CCLE 5.0593 6.6074 2.493 0.3169
Malme-3M CCLE 5.1666 8.8067 1.6416 3.402
Hs 695T CCLE 7.3017 10.7732 1.8538 0.8628
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 3.6157 4.9789 0.5654 0.1136
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-LMS-1 GDSC1; CCLE 0.7459 7.2444 -1.2039 28.0468
KYM-1 GDSC1; CCLE 1.3103 9.5209 -1.7571 28.152
GCT CCLE 1.8282 8.2474 -0.6545 22.2374
G-402 CCLE 2.342 5.0535 1.384 10.5428
SW684 GDSC1 2.5402 3.7817 0.5901 0.448
TE 617.T CCLE 2.5886 4.7516 1.7615 7.81
SW982 GDSC1 2.681 4.2622 0.4672 0.8304
TE 441.T GDSC1 2.9201 23.2854 -8.5857 34.7669
MFH-ino GDSC1 2.9275 4.8865 0.3321 1.214
EW-8 GDSC1 3.1487 4.5133 0.5598 0.2403
A-204 CCLE 3.4857 6.2121 1.7786 5.5028
Hs 729.T CCLE 3.6506 8.4741 0.7845 10.4109
RKN CCLE 3.6873 6.3709 1.8473 4.7286
SK-UT-1 GDSC1 3.7167 5.3631 0.4707 0.2462
RD CCLE 3.7341 7.1844 1.4836 6.5557
Rh30 CCLE 3.7946 5.8062 2.191 2.7561
G-401 CCLE 3.8396 6.5412 1.8709 4.3173
HT-1080 CCLE 4.2138 8.6639 1.1047 7.5839
MES-SA CCLE 4.4383 6.5273 2.2416 1.6256
VA-ES-BJ GDSC1 4.928 15.0272 -3.0725 16.2313
SW872 GDSC1 4.9335 19.5047 -5.2146 23.7805
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-5 GDSC1 -2.5003 4.027 -3.9254 46.3387
MKN45 CCLE -0.1554 2.831 -0.3989 28.1689
NUGC-4 CCLE 1.5621 4.5179 0.8588 15.7538
MKN74 CCLE 1.9823 4.6792 1.2121 12.5563
IM95 CCLE 2.1048 4.1984 1.5545 10.3877
Fu97 CCLE 2.8609 5.045 1.8593 6.5357
SNU-16 GDSC1; CCLE 3.0779 5.2792 1.9246 5.6362
Hs 746.T CCLE 3.1317 9.3554 -0.0686 15.9251
RF-48 GDSC1 3.3391 5.1877 0.3911 0.6329
HSC-39 GDSC1 3.432 4.9895 0.4973 0.2821
OCUM-1 CCLE 3.5328 6.2155 1.8118 5.2276
GCIY GDSC1; CCLE 3.899 5.7001 2.3053 2.0283
AZ-521 CCLE 4.162 6.6913 2.0094 3.0721
HGC-27 CCLE 4.2157 6.6884 2.0435 2.8251
RERF-GC-1B CCLE 4.2185 6.8781 1.9579 3.2377
NUGC-3 CCLE 4.2859 6.8251 2.0232 2.8201
SNU-1 GDSC1; CCLE 4.3118 7.0201 1.9495 3.1373
SH-10-TC CCLE 4.649 6.1437 2.499 0.4957
NCI-N87 CCLE 4.8666 6.9381 2.2836 1.0472
BGC-823 CCLE 5.0374 7.5586 2.1114 1.5419
KE-39 CCLE 5.123 9.9739 1.0836 6.1009
MKN7 CCLE 5.5576 7.3202 2.4276 0.2785
SNG-M CCLE 2.978 5.1145 1.9243 5.8835
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 2.8958 4.7642 0.366 1.086
B-CPAP CCLE 3.1106 5.106 2.0377 4.9457
K5 GDSC1 3.431 4.9459 0.512 0.2499
8305C CCLE 3.5105 5.967 1.9174 4.7114
SW579 CCLE 3.7079 5.2131 2.413 1.791
8505C CCLE 4.954 8.7486 1.5447 4.1412
TT2609-C02 CCLE 5.5876 7.8642 2.2401 0.7037
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 CCLE 1.9395 7.9851 -0.4235 20.8699
SCC-15 GDSC1 2.0204 3.8183 0.323 2.5832
Hs 840.T CCLE 2.4705 7.0225 0.5321 14.6679
BB49-HNC GDSC1 2.4771 11.8747 -3.2608 23.0848
BB30-HNC GDSC1 2.7216 4.7701 0.283 1.707
Detroit 562 CCLE 2.9098 7.2224 0.8132 12.0292
CAL-27 CCLE 2.9201 5.2533 1.8061 6.6703
SCC-25 CCLE 3.0089 9.8683 -0.4267 17.9116
LB771-HNC GDSC1 3.402 5.3174 0.3685 0.6716
HSC-2 CCLE 3.679 5.5282 2.2471 2.6671
FaDu CCLE 3.8641 6.6851 1.8184 4.5445
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CCLE 2.7868 5.3972 1.6194 8.0281
TCCSUP CCLE 2.996 5.0876 1.9529 5.6837
639V CCLE 3.1731 5.7813 1.7509 6.3493
KMBC-2 CCLE 3.2212 8.3554 0.5044 12.8577
SCaBER CCLE 3.6155 5.2678 2.3288 2.3602
RT-4 CCLE 3.6319 9.3477 0.3362 12.738
SW780 CCLE 3.7904 7.7587 1.2429 7.7097
J82 CCLE 3.924 8.3794 1.0361 8.5159
RT-112 CCLE 4.0225 7.2796 1.6407 5.1737
UM-UC-3 CCLE 4.5294 7.8893 1.6819 4.1111
5637 CCLE 4.5501 7.2751 1.9743 2.6835
HT-1376 CCLE 5.0795 7.5609 2.131 1.4277
T24 CCLE 5.2167 9.6645 1.2838 4.9982
HT-1197 CCLE 5.3545 6.7378 2.5562 0.1269
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW962 GDSC1 2.2367 4.682 0.059 3.9548
NCC-IT GDSC1 2.2831 4.111 0.3388 2.0153
JAR GDSC1 3.2927 4.8322 0.5012 0.3259
DSH1 GDSC1 3.3989 5.1208 0.4387 0.4483
NT2-D1 GDSC1 3.5699 14.9535 -3.9682 22.8836
LB831-BLC GDSC1 3.7609 5.8013 0.3329 0.5788
OMC-1 [Human cervical carcinoma] GDSC1 3.8922 5.6986 0.418 0.3004
SW954 GDSC1 4.0993 5.8258 0.4478 0.1884
KGN GDSC1 4.5132 6.4924 0.3666 0.2256
NEC8 GDSC1 4.9 18.7838 -4.8888 22.8933
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5700).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815).
3 HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma. Lab Invest. 2011 Jan;91(1):124-37. doi: 10.1038/labinvest.2010.136. Epub 2010 Jul 26.
4 Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res. 2011 Feb 1;71(3):1081-91. doi: 10.1158/0008-5472.CAN-10-1623. Epub 2011 Jan 25.