Details of the Drug

General Information of Drug (ID: DMCJLD1)

Drug Name
SCH 727965
Synonyms Dinaciclib; SCH-727965
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 396.5
Logarithm of the Partition Coefficient (xlogp) 1.9
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C21H28N6O2
IUPAC Name
2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
Canonical SMILES
CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
InChI
InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
InChIKey
PIMQWRZWLQKKBJ-SFHVURJKSA-N
Cross-matching ID
PubChem CID
46926350
ChEBI ID
CHEBI:95060
CAS Number
779353-01-4
UNII
4V8ECV0NBQ
DrugBank ID
DB12021
TTD ID
D0D3PX
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 1 (CDK1) TTH6V3D CDK1_HUMAN Inhibitor [2]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [2]
Cyclin-dependent kinase 9 (CDK9) TT1LVF2 CDK9_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Gene/Protein Processing [3]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 12 (CDK12) OTZUDGNU CDK12_HUMAN Gene/Protein Processing [3]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Gene/Protein Processing [3]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Gene/Protein Processing [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute lymphoblastic leukaemia
ICD Disease Classification 2A85
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cyclin-dependent kinase 1 (CDK1) DTT CDK1 5.27E-108 1.97 3.12
Cyclin-dependent kinase 2 (CDK2) DTT CDK2 2.28E-06 0.12 0.19
Cyclin-dependent kinase 9 (CDK9) DTT CDK9 4.38E-01 -0.04 -0.1
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 -0.762 6.7735 -4.041 25.6158
HOS GDSC2; CTRP2 -9.7652 40.1754 -25.4922 58.4171
SaOS-2 GDSC2; CTRP2 -8.6177 16.3432 -13.5977 63.7265
TC71 CTRP2 -8.5347 -6.711 -8.5347 94.5468
A-673 GDSC2; CTRP2 -7.4444 -3.3949 -7.4469 81.6511
SK-N-MC CTRP2 -6.5026 -5.9782 -6.5026 83.5899
SK-ES-1 GDSC2; CTRP2 -6.214 -5.2532 -6.214 76.5691
EW-12 GDSC2 -6.0205 -4.3297 -6.0211 60.3735
ES5 GDSC2 -6.0037 -3.5732 -6.0133 59.9912
SK-PN-DW GDSC2 -5.9113 -4.7839 -5.9113 59.3188
TC-71 GDSC2 -5.9028 -3.5675 -5.911 59.0452
NY GDSC2 -5.7782 -4.0421 -5.7793 57.9506
EW-7 GDSC2 -5.7038 -4.6607 -5.7038 57.2375
CHSA8926 GDSC2 -5.6787 -3.4938 -5.6853 56.8865
MHH-ES-1 GDSC2 -5.6002 -2.3724 -5.6638 55.7845
HuO9 GDSC2 -5.5875 -3.5664 -5.5917 56.0131
U2OS GDSC2 -5.5147 -2.5545 -5.559 55.0764
ES7 GDSC2 -5.488 -3.3127 -5.4957 55.0043
CHSA0108 GDSC2 -5.4383 -2.148 -5.5155 54.2523
EW-22 GDSC2 -5.4169 -3.9456 -5.4174 54.3541
EW-1 GDSC2 -5.0701 0.6637 -5.7276 50.6518
ES8 GDSC2 -4.9303 -0.6856 -5.2101 49.5503
EW-3 GDSC2 -4.7549 -1.2552 -4.9083 47.9085
EW-11 GDSC2 -4.664 -1.2766 -4.8069 47.0481
HuO-3N1 GDSC2 -4.5404 4.2785 -6.5388 47.5544
EW-18 GDSC2 -4.3991 -1.8399 -4.4513 44.3126
NOS-1 [Human HNSCC] GDSC2 -4.1855 -1.5612 -4.2552 42.2623
CHSA0011 GDSC2 -3.7736 4.8546 -6.0048 43.2299
EW-13 GDSC2 -3.548 3.6347 -5.2353 40.8401
EW-16 GDSC2 -2.7512 4.2924 -4.7196 35.7551
CADO-ES1 GDSC2 -2.7374 1.6471 -3.5562 31.469
ES6 GDSC2 -2.2309 17.8556 -10.8489 42.7071
CAL-78 GDSC2 -1.6438 2.9897 -3.0165 24.0795
CAL-72 GDSC2 -1.6214 5.3293 -4.1127 28.9776
EW-24 GDSC2 -0.8746 8.9762 -5.2363 30.2228
ES4 GDSC2 0.1429 12.1201 -5.9414 29.2476
U-CH2 GDSC2 0.4353 9.9816 -4.6329 24.2831
H-EMC-SS GDSC2 0.4846 10.2592 -4.7316 24.5081
G-292 clone A141B1 GDSC2; CTRP2 3.122 27.1018 -7.009 39.0267
Hs 822.T CTRP2 6.1391 7.0754 5.6056 1.6696
Hs 888.T CTRP2 9.0612 29.0129 -3.0328 24.928
MG-63 GDSC2; CTRP2 13.1394 37.5894 -4.2782 21.2826
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 184 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 -6.4477 -5.6707 -6.4477 83.2221
JM1 GDSC2; CTRP2 -8.172 -6.4761 -8.172 88.3496
HD-MY-Z CTRP2 -12.8237 9.6593 -15.6365 74.4064
HuT 78 CTRP2 -9.8026 9.8323 -12.4149 70.7913
EoL-1 GDSC2; CTRP2 -9.5013 -8.2771 -9.5013 95.8465
EB1 CTRP2 -9.4308 4.061 -10.3468 76.3294
GA-10 GDSC2; CTRP2 -9.2057 -8.3184 -9.2057 94.8988
SUP-M2 GDSC2; CTRP2 -9.1657 -5.0798 -9.1668 89.1894
697 GDSC2; CTRP2 -8.927 -6.0239 -8.927 90.4167
Pfeiffer CTRP2 -8.8343 -6.1184 -8.8343 93.8425
OCI-AML-3 GDSC2; CTRP2 -8.8125 -7.3478 -8.8125 92.1208
A4/Fukuda GDSC2; CTRP2 -8.7528 -5.6934 -8.7528 89.3864
Mino CTRP2 -8.6811 -8.0806 -8.6811 97.5532
HH [Human lymphoma] GDSC2; CTRP2 -8.3767 -5.5461 -8.3767 88.0206
BL-70 CTRP2 -8.1415 -6.32 -8.1415 92.77
ST486 GDSC2; CTRP2 -7.7927 -6.043 -7.7927 86.116
Hs 611.T CTRP2 -7.7427 -5.607 -7.7427 90.2323
L-540 GDSC2 -7.6275 -3.999 -7.6597 73.1029
DB GDSC2; CTRP2 -7.6174 -5.4105 -7.6175 84.7577
OCI-Ly3 CTRP2 -7.6161 -5.195 -7.6161 89.1173
CRO-AP2 GDSC2 -7.3128 -5.8779 -7.3128 73.2724
MOLP-8 GDSC2; CTRP2 -7.2078 -5.0523 -7.2078 82.4197
OCI-Ly10 CTRP2 -7.1507 -4.0597 -7.1509 85.6298
OPM-2 GDSC2; CTRP2 -7.1133 -4.977 -7.1133 81.872
Daudi GDSC2; CTRP2 -7.1032 -5.048 -7.1032 81.8565
JeKo-1 GDSC2; CTRP2 -7.0091 -5.9485 -7.0091 81.5295
OCI-Ly7 GDSC2 -6.9365 -5.6236 -6.9366 69.5714
SIG-M5 GDSC2; CTRP2 -6.9231 -5.4159 -6.9231 80.9488
Namalwa GDSC2; CTRP2 -6.918 -5.0263 -6.918 80.8136
BC-3 GDSC2 -6.904 -5.9211 -6.904 69.2773
KMS-11 GDSC2 -6.8901 -5.0952 -6.8905 68.9571
NALM-6 GDSC2 -6.8622 2.5026 -8.2955 59.8057
SUP-B8 GDSC2 -6.81 -5.3769 -6.81 68.2874
SET-2 CTRP2 -6.8054 -5.7811 -6.8054 85.577
AML-193 CTRP2 -6.763 -4.6946 -6.763 84.7482
PL-21 GDSC2 -6.759 -4.8423 -6.7597 67.6115
NB4 GDSC2 -6.7566 -5.6288 -6.7566 67.7933
EJM GDSC2; CTRP2 -6.7446 -2.4287 -6.7504 77.7261
CTV-1 GDSC2 -6.7117 -1.395 -6.9964 63.1979
MOTN-1 CTRP2 -6.7116 -5.7983 -6.7116 84.9702
SUP-B15 GDSC2; CTRP2 -6.7113 -4.0856 -6.7114 79.2016
MOLT-3 CTRP2 -6.704 -5.9438 -6.704 84.9286
KY821 GDSC2 -6.689 -5.3803 -6.689 67.1002
OCI-Ly19 GDSC2; CTRP2 -6.6592 -5.3008 -6.6592 79.3322
BE-13 GDSC2 -6.6586 -4.5673 -6.6604 66.5372
RCH-ACV GDSC2 -6.6146 -5.0022 -6.6148 66.3026
SEM CTRP2 -6.6068 -5.6758 -6.6068 84.2734
BC-1 GDSC2 -6.5935 -4.9914 -6.5937 66.0957
CA46 GDSC2; CTRP2 -6.588 -2.9306 -6.5897 77.6269
SUP-HD1 GDSC2; CTRP2 -6.5772 -2.7775 -6.5795 77.421
SR GDSC2 -6.5658 -4.4526 -6.5679 65.6215
RL GDSC2; CTRP2 -6.5619 45.6731 -25.0549 54.7793
JVM-2 GDSC2 -6.5572 -3.7222 -6.5731 64.9905
Kasumi-1 GDSC2; CTRP2 -6.5563 -5.5721 -6.5563 78.7067
KO52 CTRP2 -6.5478 -6.0617 -6.5478 83.8907
AMO1 GDSC2 -6.5415 -5.0881 -6.5416 65.6079
DoHH2 GDSC2 -6.5387 -5.4037 -6.5388 65.6102
HuNS1 CTRP2 -6.4873 -5.7494 -6.4873 83.4863
A3/Kawakami GDSC2; CTRP2 -6.4686 -5.6952 -6.4686 78.1601
SU-DHL-16 GDSC2 -6.4566 -4.8521 -6.4568 64.734
OCI-AML-5 GDSC2; CTRP2 -6.4348 -5.996 -6.4348 77.9492
Kasumi-2 CTRP2 -6.4347 -5.9432 -6.4347 83.1378
SU-DHL-4 GDSC2 -6.4051 -4.0651 -6.4103 63.9306
JJN-3 GDSC2; CTRP2 -6.3848 -5.3897 -6.3848 77.6357
Loucy GDSC2 -6.3821 -4.729 -6.3825 63.9827
Karpas-422 GDSC2; CTRP2 -6.3505 -4.7808 -6.3505 77.3944
NU-DHL-1 CTRP2 -6.3473 -5.1284 -6.3473 82.5225
Farage GDSC2 -6.3322 -4.6178 -6.3327 63.4724
LP-1 GDSC2; CTRP2 -6.2966 -5.2686 -6.2966 77.0847
SKM-1 GDSC2 -6.2929 -5.0309 -6.2929 63.1406
TF-1 CTRP2 -6.2454 -5.7048 -6.2454 81.8767
CMK CTRP2 -6.2358 -4.3872 -6.2358 81.5984
F-36P CTRP2 -6.2078 -4.8527 -6.2078 81.5792
NU-DUL-1 GDSC2 -6.2067 -5.0431 -6.2067 62.2803
RPMI-6666 GDSC2; CTRP2 -6.1977 -5.6414 -6.1977 76.468
KMS-20 CTRP2 -6.197 -5.4359 -6.197 81.5534
U-698-M GDSC2 -6.1922 -4.8338 -6.1923 62.1259
HL-60 GDSC2; CTRP2 -6.1903 -5.8012 -6.1903 76.4221
BCP-1 CTRP2 -6.1883 -4.7434 -6.1883 81.4325
KMS-12-BM GDSC2 -6.1717 -5.1193 -6.1717 61.932
NCI-H929 GDSC2 -6.1472 -3.8907 -6.1524 61.4665
SCC-3 GDSC2 -6.14 -4.9929 -6.14 61.612
HEL 92.1.7 CTRP2 -6.0958 -5.4337 -6.0958 80.8796
M-07e CTRP2 -6.0746 -4.855 -6.0746 80.718
SU-DHL-1 GDSC2 -6.0706 -5.2155 -6.0707 60.9194
MOLM-13 GDSC2 -6.0586 -4.9639 -6.0586 60.797
Karpas-620 GDSC2 -6.0537 -5.0364 -6.0537 60.7488
TK [Human B-cell lymphoma] GDSC2 -6.0443 -2.9222 -6.0841 59.9804
DND-41 GDSC2; CTRP2 -6.0276 -4.7553 -6.0276 75.4015
HT GDSC2 -6.0163 -2.9572 -6.0528 59.7626
KE-37 GDSC2 -6.004 -4.8834 -6.004 60.2485
TUR GDSC2 -5.99 -4.9048 -5.99 60.1086
OCI-AML-2 GDSC2 -5.9785 -4.9814 -5.9785 59.9942
BONNA-12 GDSC2 -5.9615 -3.6189 -5.9694 59.6168
MLMA GDSC2 -5.9538 -4.8994 -5.9538 59.7459
JSC-1 GDSC2 -5.943 -4.7789 -5.943 59.6359
MOLM-16 GDSC2 -5.9358 -4.8376 -5.9358 59.565
DEL GDSC2 -5.9121 -4.7531 -5.9121 59.3264
Jurkat GDSC2 -5.8972 -2.2659 -5.9879 58.2821
ATN-1 GDSC2 -5.8895 -4.8826 -5.8895 59.1008
ML-2 GDSC2 -5.8587 -4.9749 -5.8587 58.7924
Karpas-231 GDSC2 -5.8411 -4.3436 -5.8414 58.6015
Karpas-299 GDSC2 -5.8231 -5.0487 -5.8231 58.4352
SU-DHL-6 GDSC2 -5.8073 -4.8296 -5.8073 58.2764
L-363 GDSC2 -5.7955 -5.1064 -5.7955 58.1585
MY-M12 GDSC2 -5.7848 -1.973 -5.9043 57.163
RS4;11 GDSC2 -5.7803 -4.641 -5.7803 58.0042
Ramos.2G6.4C10 GDSC2 -5.7561 -4.8123 -5.7561 57.7625
P30/OHK GDSC2 -5.7454 -4.8006 -5.7454 57.6558
MHH-CALL-4 GDSC2 -5.7233 -3.598 -5.7285 57.34
EM-2 GDSC2 -5.7166 -4.7967 -5.7166 57.3666
WSU-NHL GDSC2 -5.7113 -4.9601 -5.7113 57.3138
L-1236 GDSC2 -5.7063 -3.678 -5.7101 57.191
CESS GDSC2 -5.6991 -4.8654 -5.6991 57.1914
GDM-1 GDSC2 -5.6987 -2.8598 -5.7297 56.8752
CCRF-CEM GDSC2 -5.6971 -4.5871 -5.6971 57.1695
JVM-3 GDSC2 -5.689 -3.7058 -5.6923 57.0269
MOLT-13 GDSC2 -5.6779 -4.8011 -5.6779 56.9784
CTB-1 GDSC2 -5.6705 0.1472 -6.2292 55.0657
RPMI-8226 GDSC2 -5.6425 -4.8407 -5.6425 56.6229
P32/ISH GDSC2 -5.6323 -4.8431 -5.6323 56.5208
QIMR-WIL GDSC2 -5.6117 -4.6543 -5.6117 56.3141
SU-DHL-5 GDSC2 -5.6115 -5.0337 -5.6115 56.3124
IM-9 GDSC2 -5.6088 -4.9366 -5.6088 56.2851
NOMO-1 GDSC2 -5.5998 -4.864 -5.5998 56.1947
H9 GDSC2 -5.5884 -2.465 -5.6431 55.7159
LAMA-84 GDSC2 -5.5802 -3.7425 -5.5823 55.9638
U266B1 GDSC2; CTRP2 -5.5727 -4.6473 -5.5727 72.5639
MM1.S GDSC2 -5.5713 -4.8362 -5.5713 55.9083
MHH-CALL-2 GDSC2 -5.5631 -4.5702 -5.5631 55.826
CML-T1 GDSC2 -5.5534 -4.6705 -5.5534 55.7288
ALL-PO GDSC2 -5.5483 -2.5259 -5.5961 55.3741
BALL-1 GDSC2 -5.5472 -3.362 -5.5547 55.5872
Hs 445 GDSC2 -5.547 -1.7051 -5.6877 55.0361
MOLT-16 GDSC2 -5.5421 -4.8532 -5.5421 55.6159
LC4-1 GDSC2 -5.5377 -4.453 -5.5377 55.5709
RPMI-8866 GDSC2 -5.5371 -3.1706 -5.5496 55.4527
THP-1 GDSC2 -5.5196 -4.5509 -5.5196 55.3898
MC116 GDSC2 -5.5183 -5.1047 -5.5183 55.3768
Ku812 GDSC2 -5.5112 -3.8871 -5.5121 55.292
Karpas-1106P GDSC2 -5.5001 -2.3895 -5.5571 54.8891
KCL-22 GDSC2 -5.4953 -4.5166 -5.4953 55.1453
TALL-1 [Human adult T-ALL] GDSC2 -5.4744 -3.6869 -5.4764 54.9135
HDLM-2 GDSC2 -5.4704 -4.2729 -5.4705 54.8953
NK-92MI GDSC2 -5.4526 -4.5563 -5.4526 54.7173
SU-DHL-8 GDSC2 -5.429 -1.8158 -5.5459 54.0634
VL51 GDSC2 -5.424 -1.2035 -5.6395 53.8097
Raji GDSC2 -5.3874 -2.5706 -5.4251 53.8968
Reh GDSC2 -5.3701 -3.9738 -5.3704 53.8863
WIL2 NS GDSC2 -5.3635 -4.3546 -5.3635 53.8233
SU-DHL-10 GDSC2 -5.3454 -4.612 -5.3454 53.6419
EB2 GDSC2 -5.3223 -1.5454 -5.4712 53.052
P12-Ichikawa GDSC2 -5.2924 -3.7877 -5.293 53.105
Karpas-45 GDSC2 -5.2757 -3.431 -5.2788 52.9264
RC-K8 GDSC2 -5.2222 -1.8994 -5.315 52.2326
HEL GDSC2 -5.196 -3.2871 -5.2004 52.1284
ARH-77 GDSC2 -5.177 -2.7325 -5.198 51.9081
KOPN-8 GDSC2 -5.0436 -3.4024 -5.0454 50.6119
K-562 GDSC2; CTRP2 -5.0394 -2.4892 -5.0396 69.1302
SK-MM-2 GDSC2 -5.0181 -3.4976 -5.0191 50.3569
VAL GDSC2 -4.9065 2.0705 -6.0346 49.5002
OCI-M1 GDSC2; CTRP2 -4.7809 -0.6461 -4.7928 66.9303
KG-1 GDSC2 -4.7468 -3.1248 -4.7492 47.6405
L-428 GDSC2; CTRP2 -4.7198 -2.3927 -4.7199 67.1905
JURL-MK1 GDSC2 -4.7178 -0.6735 -4.9817 47.6771
ALL-SIL GDSC2 -4.6537 -2.8988 -4.6583 46.7131
KM-H2 GDSC2 -4.6502 -0.0846 -5.052 47.2228
MEG-01 GDSC2 -4.638 -1.6434 -4.7258 46.7188
Jiyoye GDSC2 -4.538 -0.9655 -4.7262 45.9413
HAL-01 GDSC2 -4.3359 -2.8151 -4.3385 43.5224
ME1 GDSC2 -4.2263 -2.6928 -4.2296 42.4261
HC-1 GDSC2 -4.1873 -0.3703 -4.4742 42.9033
SUP-T1 GDSC2 -3.6853 -0.1635 -3.9784 38.2036
ROS-50 GDSC2 -3.4152 2.5806 -4.6498 38.7843
PF-382 GDSC2 -3.1901 2.3167 -4.3047 36.5912
DG-75 GDSC2 -3.0829 3.661 -4.7697 37.44
MHH-PREB-1 GDSC2 -2.2253 3.5999 -3.8762 30.4858
GR-ST GDSC2 -1.9125 7.5118 -5.4486 34.3647
Granta-519 GDSC2; CTRP2 -1.8344 7.4195 -2.9653 49.418
KMOE-2 GDSC2 -1.8013 4.4142 -3.8429 28.588
MN-60 GDSC2 -0.4157 8.1857 -4.4442 26.0857
MOLT-4 GDSC2 2.2679 4.0668 -0.5927 0.4992
Toledo CTRP2 5.8486 21.9554 -2.0748 28.4295
BL-41 GDSC2; CTRP2 7.2669 24.5732 -2.222 25.2018
⏷ Show the Full List of 184 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -8.6479 5.0734 -9.7353 73.8699
KYSE-150 CTRP2 -7.9602 24.8539 -16.5968 60.5015
EC-GI-10 GDSC2; CTRP2 -6.2392 -5.287 -6.2392 76.7271
KYSE-270 GDSC2 -6.2001 -4.2622 -6.2016 62.1032
TE-11 GDSC2; CTRP2 -5.8259 -4.8878 -5.8259 74.1457
KYSE-450 GDSC2; CTRP2 -5.8075 -0.4066 -5.8468 71.5574
OE21 GDSC2; CTRP2 -5.6704 -3.4556 -5.6704 73.0862
KYSE-180 GDSC2 -5.6065 -3.0288 -5.626 56.0769
TE-8 GDSC2 -5.5496 -4.1684 -5.5498 55.6864
KYSE-510 GDSC2; CTRP2 -5.3376 5.3038 -6.183 64.006
TE-5 GDSC2; CTRP2 -5.2818 2.7957 -5.6048 66.1142
TE-15 GDSC2 -5.1168 -0.43 -5.4728 51.1094
TE-4 GDSC2 -5.0021 0.0072 -5.4609 50.1565
TE-6 GDSC2 -4.9318 0.2759 -5.46 49.6019
TE-9 GDSC2 -4.8869 -3.116 -4.8907 49.0447
TE-14 CTRP2 -4.4402 -1.4895 -4.4413 69.5511
TE-10 GDSC2 -3.9416 -0.6311 -4.1472 40.346
OE33 GDSC2; CTRP2 -3.3866 16.1701 -8.0739 53.7497
KYSE-140 GDSC2 -3.028 2.8476 -4.3583 35.9491
TE-1 GDSC2 -2.8308 1.7929 -3.7132 32.5959
KYSE-70 GDSC2 -1.7068 3.3541 -3.2489 25.5046
KYSE-410 GDSC2 -0.9977 9.6391 -5.6743 31.8577
COLO 680N GDSC2 -0.227 8.6242 -4.5026 25.7227
KYSE-520 GDSC2; CTRP2 -0.0962 13.4728 -3.5165 43.3923
OE19 GDSC2; CTRP2 0.1706 143.8882 -67.8315 49.1866
KYSE-30 CTRP2 7.4051 74.4061 -27.0092 42.8176
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 -15.8928 14.4929 -20.638 73.51
Panc 03.27 CTRP2 -12.6098 20.3553 -19.4424 67.4505
Hs 766T CTRP2 -6.918 26.1161 -16.1221 58.8001
MIA PaCa-2 GDSC2; CTRP2 -6.4432 4.2659 -7.1425 68.2155
KP-2 GDSC2; CTRP2 -6.3225 12.8147 -9.7576 61.5124
DAN-G GDSC2; CTRP2 -5.73 -4.6354 -5.73 73.5461
BxPC-3 GDSC2 -5.6348 -4.6199 -5.6348 56.5454
KP-4 GDSC2 -5.2052 0.7003 -5.8862 51.6289
Panc 08.13 GDSC2; CTRP2 -4.9282 0.5425 -4.9882 66.7949
CFPAC-1 GDSC2 -3.9858 -0.0093 -4.3473 41.2469
QGP-1 GDSC2 -3.6064 3.4359 -5.2099 41.0874
HuP-T4 GDSC2 -3.3604 0.448 -3.7987 35.6789
PSN1 GDSC2; CTRP2 -3.2583 3.7479 -3.5858 56.863
PL4 GDSC2 -3.0214 2.4825 -4.1967 35.3775
Capan-1 GDSC2; CTRP2 -2.3749 8.9808 -4.0851 51.6815
HPAC GDSC2 -2.0501 3.9381 -3.8599 29.6753
KP-1N GDSC2 -1.9198 3.4992 -3.5264 27.6864
HuP-T3 GDSC2; CTRP2 -1.5432 7.5657 -2.6965 48.0552
PaTu 8988t GDSC2; CTRP2 -1.3884 58.0229 -26.3723 49.475
PaTu 8902 GDSC2 -1.3636 5.6498 -4.0286 27.6754
HPAF-II GDSC2 -1.054 5.4695 -3.6561 24.9611
Panc 04.03 CTRP2 -0.9415 88.6157 -41.1983 49.6824
KP-3 GDSC2 -0.9089 8.049 -4.805 28.9595
PaTu 8988s CTRP2 -0.2073 1241.569 -616.9353 49.9446
SW1990 CTRP2 0.078 167.0403 -79.478 49.4942
SUIT-2 GDSC2 0.2604 5.9816 -2.7767 16.3283
MZ-PC-1 GDSC2 0.6143 6.6959 -2.8508 15.7399
SU.86.86 GDSC2 0.6184 10.5368 -4.7623 24.2542
YAPC GDSC2 0.8035 11.2321 -4.9613 24.4648
AsPC-1 GDSC2; CTRP2 2.9549 15.7409 -1.5698 32.3628
Panc 10.05 GDSC2; CTRP2 3.497 49.1928 -17.6877 43.5552
PK-45H CTRP2 4.2336 48.0768 -16.4992 42.9945
Capan-2 GDSC2; CTRP2 4.844 67.7452 -25.812 44.1234
Panc 02.03 GDSC2; CTRP2 8.4095 32.2484 -5.1425 28.5514
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -3.5579 21.2146 -10.5144 54.4744
HMCB CTRP2 -8.2176 0.9 -8.4762 79.1084
A-431 GDSC2 -7.1907 -5.9272 -7.1907 72.1134
WM88 CTRP2 -6.3065 -2.2455 -6.3111 79.6779
MZ-MEL-7 GDSC2 -6.293 4.0104 -8.2646 56.3642
K029AX CTRP2 -6.2455 -5.7818 -6.2455 81.8774
RVH-421 GDSC2; CTRP2 -6.2292 -5.2996 -6.2292 76.6645
SK-MEL-30 GDSC2 -6.1989 -2.0117 -6.3408 60.4499
Hs 294T CTRP2 -6.1726 -5.5616 -6.1726 81.3915
IPC-298 GDSC2 -6.1379 -1.8049 -6.306 59.8005
A-375 GDSC2 -6.0951 -4.584 -6.0953 61.1415
MeWo CTRP2 -6.0828 1.2886 -6.2588 73.4956
CP50-MEL-B GDSC2 -6.0254 -2.2287 -6.128 59.2995
CJM [Human melanoma] CTRP2 -6.0176 -5.391 -6.0176 80.3585
Malme-3M CTRP2 -6.0136 11.6664 -8.9863 62.9231
MZ-MEL-2 GDSC2 -6.0088 -4.5101 -6.009 60.2792
A-388 GDSC2 -6.0037 -2.408 -6.0852 59.2636
Hs 938.T GDSC2 -5.9181 -4.8263 -5.9181 59.3869
DJM-1 GDSC2 -5.8027 -4.5258 -5.8028 58.2265
LB373-MEL-D GDSC2 -5.7705 -4.733 -5.7705 57.9069
G-mel GDSC2 -5.7642 -4.6663 -5.7642 57.843
HT-144 GDSC2; CTRP2 -5.7632 -2.3389 -5.7648 73.1233
SK-MEL-28 GDSC2 -5.7472 -1.926 -5.8705 56.824
COLO 800 GDSC2; CTRP2 -5.7155 -0.8859 -5.7363 71.6661
RPMI-7951 GDSC2 -5.701 -3.7402 -5.704 57.1506
Mel Ho GDSC2 -5.6124 -3.487 -5.6182 56.2426
VMRC-MELG GDSC2 -5.5579 -0.4861 -5.94 54.5692
IGR-37 GDSC2; CTRP2 -5.4962 -4.7166 -5.4962 72.0865
UACC-62 GDSC2; CTRP2 -5.4056 -1.6223 -5.4101 70.7989
COLO 783 GDSC2 -5.3952 -4.5348 -5.3952 54.1415
COLO 792 GDSC2; CTRP2 -5.3939 -4.0928 -5.3939 71.4455
LB2518-MEL GDSC2 -5.2567 -1.1825 -5.4626 52.3998
LOX-IMVI GDSC2; CTRP2 -5.2182 8.8317 -7.1069 61.1321
CHL-1 GDSC2 -5.1788 -2.8542 -5.1945 51.9344
WM1552C GDSC2 -5.0845 -1.8901 -5.1699 50.9587
A101D GDSC2; CTRP2 -5.0208 -3.2649 -5.0208 69.1065
WM266-4 CTRP2 -4.7029 2.5902 -4.9538 67.0472
A2058 GDSC2; CTRP2 -4.6981 -2.6314 -4.6982 67.0797
COLO 679 GDSC2 -4.6271 1.2398 -5.4354 47.3913
SK-MEL-31 GDSC2 -4.5844 0.2891 -5.0849 46.772
M14 GDSC2 -4.3883 0.6404 -4.9782 45.2616
G-361 GDSC2 -4.2568 -3.2858 -4.2569 42.7177
COLO 829 GDSC2; CTRP2 -4.2105 -0.6519 -4.2163 63.788
CP66-MEL GDSC2 -4.0266 -1.592 -4.0836 40.645
IGR-1 GDSC2; CTRP2 -3.9354 2.73 -4.1534 60.597
GAK GDSC2 -3.842 -1.3778 -3.9126 38.8669
HMV-II GDSC2 -3.7729 2.3076 -4.9162 41.3705
SK-MEL-3 GDSC2; CTRP2 -3.7536 2.806 -3.9698 59.6948
Mel JuSo GDSC2 -3.7335 1.0311 -4.3963 39.8488
WM793 GDSC2 -3.5768 -0.5945 -3.7587 36.7141
SK-MEL-2 GDSC2; CTRP2 -3.5622 3.2628 -3.832 58.5422
WM278 GDSC2 -3.1814 6.3655 -6.1091 40.7379
WM35 GDSC2 -3.0688 4.3215 -5.0517 38.1044
WM115 GDSC2; CTRP2 -2.736 3.2129 -2.9396 54.3608
MMAc-SF GDSC2 -2.412 7.9834 -6.145 37.778
WM983B CTRP2 -2.2463 51.5972 -23.9632 50.7952
SH-4 GDSC2 -1.974 4.6383 -4.1164 30.3821
SK-MEL-5 GDSC2 -1.9239 4.5495 -4.0258 29.8262
451Lu GDSC2 0.557 6.5448 -2.8206 15.7337
UACC-257 GDSC2; CTRP2 0.5638 10.6741 -1.6212 39.0832
Hs 839.T CTRP2 2.0334 15.9294 -2.5394 37.8311
Hs 940.T GDSC2; CTRP2 2.8548 16.4829 -2.0239 33.465
Hs 895.T CTRP2 3.1552 30.3596 -8.5976 41.0494
Hs 934.T CTRP2 7.1772 10.8814 4.4925 4.6329
Hs 688(A).T CTRP2 7.1914 9.7721 5.0276 2.5009
SK-MEL-24 GDSC2; CTRP2 7.8121 35.1764 -7.0759 31.8668
WT2-iPS GDSC2; CTRP2 12.1557 35.8784 -4.1373 22.1488
IGR-39 CTRP2 12.4323 35.7468 -3.8789 22.0425
EquiPSC Line K2 GDSC2 -4.2359 -0.002 -4.6222 43.5786
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC2 -6.4606 -2.7764 -6.5303 63.2241
KYSE-220 GDSC2 -5.4881 -0.621 -5.8319 54.0994
ESO-26 GDSC2 -5.3468 -1.2833 -5.5415 53.1903
HCE-4 GDSC2 -4.7514 -1.6434 -4.8465 47.8142
TE-12 GDSC2 -3.948 0.5672 -4.4759 41.3622
OACP4 C GDSC2 -3.4468 2.1836 -4.5215 38.5976
OACM5.1 C GDSC2 -2.8935 2.1802 -3.9369 33.7994
ESO-51 GDSC2 -2.0291 4.6189 -4.1606 30.7752
KYSE-50 GDSC2 -0.7468 9.0216 -5.1473 29.5439
SK-GT-4 GDSC2 -0.5138 15.3697 -8.1171 35.5382
KYAE-1 GDSC2 1.5129 9.6071 -3.6084 17.2028
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2; CTRP2 -4.5146 12.6224 -7.7623 57.4853
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 -7.5757 3.9801 -8.3111 73.3132
SK-N-MC-IXC GDSC2 -6.4773 -4.9223 -6.4775 64.95
SK-N-FI CTRP2 -6.4226 -3.5315 -6.4228 81.8724
Kelly GDSC2 -6.1961 -3.3496 -6.2176 61.597
KP-N-YS GDSC2 -6.1756 -4.5699 -6.1759 61.9331
SK-N-BE(2) CTRP2 -6.1546 8.743 -8.0926 65.2772
SK-N-SH CTRP2 -5.95 25.2754 -14.769 57.6595
SJNB-13 GDSC2 -5.5539 -2.3311 -5.6189 55.3537
SJNB-5 GDSC2 -5.5123 -3.0771 -5.5275 55.1947
SK-N-AS GDSC2; CTRP2 -5.4416 -0.6366 -5.4644 70.1911
SJNB-7 GDSC2 -5.1386 -1.7615 -5.2435 51.4485
TGW GDSC2 -4.7338 -0.4611 -5.0479 47.8621
SK-N-DZ GDSC2; CTRP2 -4.4783 1.0996 -4.5575 64.249
SJNB-10 GDSC2 -4.0698 2.4521 -5.2884 43.748
NB(TU)1 GDSC2 -3.5604 0.7927 -4.1277 38.0096
IMR-5 GDSC2 -3.0509 5.5891 -5.6172 39.2832
SJNB-14 GDSC2 -2.9096 12.803 -8.963 43.076
NH-6 CTRP2 -2.8066 24.1847 -11.1545 52.6546
LA-N-6 GDSC2 -2.3257 3.8884 -4.1092 31.8316
GOTO GDSC2 -2.0789 5.8609 -4.8028 33.1714
NB69 GDSC2 -1.4204 8.4967 -5.4832 32.726
GI-ME-N GDSC2 -0.6898 8.2562 -4.7162 27.942
SiMa GDSC2 -0.6861 7.349 -4.2609 26.2481
SK-N-BE(2)-M17 GDSC2 -0.433 7.4145 -4.0739 24.6786
CHP-212 GDSC2; CTRP2 -0.4235 11.7761 -3.1154 44.0961
KP-N-RT-BM-1 GDSC2 -0.2367 6.7035 -3.551 21.7563
SJNB-6 GDSC2 -0.0989 7.8699 -4.0176 23.4055
NH-12 GDSC2 0.1786 7.239 -3.4718 20.1237
MHH-NB-11 GDSC2 0.3222 12.2845 -5.8758 28.5867
SJNB-17 GDSC2 0.3654 4.9238 -2.1644 12.5353
CHP-126 GDSC2 0.7009 13.7709 -6.3104 28.7722
CHP-134 GDSC2 1.583 3.1234 -0.5217 0.6997
KP-N-YN GDSC2; CTRP2 6.8872 19.6224 -0.0557 20.633
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 -2.4273 2.8941 -3.7605 30.8991
SNU-869 CTRP2 -2.1845 31.3256 -13.9718 51.1629
Cancer Drug Sensitivity Data Curated from 82 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 GDSC2; CTRP2 -8.0319 11.4776 -11.0812 65.5284
DU4475 GDSC2; CTRP2 -7.0838 6.0476 -8.2837 67.987
HCC1954 GDSC2 -6.7015 -5.0947 -6.7017 67.167
MDA-MB-468 GDSC2; CTRP2 -6.3189 -4.8268 -6.3189 77.2053
Hs 578T GDSC2; CTRP2 -6.2403 -4.5056 -6.2403 76.69
EFM-192A GDSC2; CTRP2 -6.1909 -1.8836 -6.1985 74.7824
CAL-85-1 GDSC2; CTRP2 -6.1747 27.3503 -15.9512 56.7113
HCC1187 GDSC2 -6.1271 -3.823 -6.1332 61.2492
HCC2157 GDSC2 -6.0679 -4.9192 -6.068 60.8894
SK-BR-3 CTRP2 -5.9546 -4.711 -5.9546 79.9209
Evsa-T GDSC2 -5.9461 -4.2609 -5.9468 59.6324
MDA-MB-157 GDSC2; CTRP2 -5.8109 -2.9095 -5.8112 73.7056
MDA-MB-330 GDSC2 -5.7425 -4.5153 -5.7425 57.6236
HCC70 GDSC2 -5.7211 -4.4049 -5.7212 57.4077
MRK-nu-1 GDSC2 -5.5517 -4.7422 -5.5517 55.7118
AU565 GDSC2; CTRP2 -5.5437 -1.4876 -5.5506 71.3985
OCUB-M GDSC2 -5.4937 -3.853 -5.4947 55.1162
BT-20 GDSC2; CTRP2 -5.3531 -3.4267 -5.3531 71.1638
MDA-MB-415 GDSC2; CTRP2 -5.1858 -3.6514 -5.1858 70.1425
CAL-51 GDSC2 -5.1841 -1.6562 -5.3065 51.8483
MDA-MB-453 GDSC2; CTRP2 -5.1497 42.2978 -22.087 53.6443
MFM-223 GDSC2 -4.8437 -1.168 -5.0192 48.7423
HCC38 GDSC2; CTRP2 -4.816 0.2893 -4.859 66.4703
HCC1806 GDSC2 -3.9496 -0.9031 -4.1016 40.2381
EFM-19 GDSC2 -3.8067 2.8133 -5.1568 42.0454
CAL-120 GDSC2 -3.7034 1.8215 -4.6524 40.363
HCC1569 GDSC2 -3.3985 3.4824 -5.015 39.6094
MDA-MB-231 GDSC2 -3.1421 3.0739 -4.5736 37.1756
UACC-893 GDSC2 -3.0697 3.7052 -4.7759 37.3936
HCC1143 GDSC2 -3.0082 6.9648 -6.2238 40.2162
BT-549 GDSC2; CTRP2 -3.0057 9.572 -4.9788 53.9361
COLO 824 GDSC2 -2.4653 2.6515 -3.6926 30.7845
UACC-812 CTRP2 -2.1847 14.757 -6.221 52.1769
CAMA-1 GDSC2 -1.8688 5.2034 -4.2861 30.5974
BT-474 GDSC2; CTRP2 -1.7691 5.9955 -2.4694 49.0304
HCC1599 GDSC2 -1.7469 3.8845 -3.5383 27.0374
HCC1500 GDSC2; CTRP2 -1.2743 9.3155 -3.0253 47.0858
HCC202 CTRP2 -1.2397 25.042 -10.0447 49.5528
YMB-1-E GDSC2 -1.2255 5.6641 -3.9085 26.6755
HCC1428 GDSC2; CTRP2 -0.8278 8.0074 -2.0703 44.6413
JIMT-1 GDSC2 -0.6743 6.1977 -3.6773 23.7507
MCF-7 GDSC2 -0.2451 15.4707 -7.9405 34.5786
ZR-75-30 GDSC2; CTRP2 0.1936 18.6434 -5.6114 44.0584
HCC1419 GDSC2; CTRP2 0.2013 13.3655 -3.1658 42.1749
MDA-MB-436 GDSC2 0.3953 14.7563 -7.0514 31.2826
HDQ-P1 GDSC2 0.8835 8.2222 -3.4 17.8142
HCC1937 GDSC2 1.3602 5.5974 -1.7623 7.7137
Hs 578Bst CTRP2 7.4196 8.7119 5.609 0.361
MDA-MB-361 GDSC2; CTRP2 10.3471 37.9864 -6.4979 27.9123
T-47D GDSC2; CTRP2 11.207 31.9073 -2.878 20.936
BT 422 CTRP2 -8.5147 38.2472 -23.363 58.1294
BT 131 CTRP2 -7.6681 23.7584 -15.8086 60.4548
BT 440 CTRP2 -6.8222 11.2521 -9.6982 64.8228
BT 145 CTRP2 -6.5862 3.5655 -7.1507 71.6661
BT 416 CTRP2 -6.462 -4.7323 -6.462 83.1058
BT164 CTRP2 -6.4234 -4.3872 -6.4234 82.6774
BT 428 CTRP2 -6.3131 -5.2149 -6.3131 82.3109
BT 482 CTRP2 -5.9686 -4.8171 -5.9686 80.0206
BT 179 CTRP2 -5.8724 -1.0477 -5.8916 76.2564
BT 228 CTRP2 -5.492 -4.7857 -5.492 76.8571
BT 159 CTRP2 -5.4751 -4.8175 -5.4751 76.7444
BT 231 CTRP2 -5.2951 -2.853 -5.2952 75.2779
BT 112 CTRP2 -4.8279 36.5135 -18.9857 54.4044
BT 359 CTRP2 -4.7257 21.6457 -11.882 56.5509
BT 245 CTRP2 -4.0664 6.2594 -5.0492 61.3492
BT 224 CTRP2 -1.5842 49.1647 -22.1622 50.1325
BT 498 CTRP2 -0.6404 44.183 -18.8471 49.0061
BT 328 CTRP2 0.4168 1121.441 -556.3505 49.908
BT 330 CTRP2 0.4828 674.1206 -332.6396 49.8415
BT 286 CTRP2 0.5135 1186.3143 -588.706 49.9086
BT 271 CTRP2 0.6274 101.4123 -46.2257 48.8646
BT 333 CTRP2 1.1227 49.9152 -20.1164 47.1221
BT 504 CTRP2 4.0082 82.527 -33.9067 46.1954
BT 320 CTRP2 7.0921 8.6915 5.4583 1.0318
BT 340 CTRP2 7.6265 8.9179 5.6174 0.2567
BT 248 CTRP2 7.8472 22.3074 -0.6378 21.5138
BT 232 CTRP2 7.9714 9.6107 5.4996 0.3621
BT 239 CTRP2 8.2982 42.0202 -10.1015 34.8902
BT147 CTRP2 8.3554 42.7138 -10.4018 35.0619
BT 172 CTRP2 9.1908 47.6723 -12.2091 35.4503
BT 444 CTRP2 9.6465 32.1969 -4.1647 26.1127
BT 216 CTRP2 10.1009 37.175 -6.283 28.6571
⏷ Show the Full List of 82 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 683 GDSC2; CTRP2 -9.5401 13.7186 -13.5375 66.4845
SF268 GDSC2; CTRP2 -8.1594 9.6816 -10.583 67.0242
D283 Med GDSC2; CTRP2 -7.6036 -3.9056 -7.6046 82.9419
TM-31 CTRP2 -7.4973 72.6678 -39.1311 54.1126
CCF-STTG1 CTRP2 -6.5271 43.1211 -23.7875 55.5319
SF539 GDSC2; CTRP2 -6.284 -5.2379 -6.284 77.0056
D-336MG GDSC2 -6.2421 -3.1106 -6.2773 61.8052
D-423MG GDSC2 -6.2233 -3.9415 -6.2285 62.1976
M059K CTRP2 -6.1214 -5.2235 -6.1214 81.048
D-566MG GDSC2 -5.6873 -4.6936 -5.6873 57.0726
D-392MG GDSC2 -5.6286 -1.4424 -5.8175 55.5861
PFSK-1 GDSC2 -5.4578 -4.0145 -5.4581 54.7639
Daoy GDSC2 -5.4256 -2.3987 -5.4783 54.2103
SNB-75 GDSC2; CTRP2 -5.3964 -2.9465 -5.3965 71.3483
YH-13 GDSC2; CTRP2 -5.3145 -2.9488 -5.3146 70.8625
SF126 GDSC2 -5.2967 -4.444 -5.2967 53.1529
Onda 10 GDSC2 -5.2587 -1.5874 -5.3965 52.5033
SF295 GDSC2 -5.1481 -0.5387 -5.4809 51.379
H4 GDSC2 -5.0539 1.0702 -5.8409 50.5113
KS-1 [Human Krukenberg tumour] GDSC2 -4.7114 -1.229 -4.8658 47.5051
ONS-76 GDSC2 -4.2336 0.9524 -4.9115 44.1275
DK-MG GDSC2; CTRP2 -4.1933 -1.1898 -4.1948 63.8282
D-542MG GDSC2 -4.1208 2.1114 -5.2094 43.9225
AM-38 GDSC2 -4.036 0.598 -4.5814 42.1788
D-263MG GDSC2 -3.8878 1.8721 -4.8688 41.9248
SK-MG-1 GDSC2 -3.7873 -0.0258 -4.1262 39.3315
GI-1 GDSC2 -3.6718 0.5184 -4.1599 38.7589
GaMG GDSC2 -3.5365 3.0753 -4.9836 40.2438
8-MG-BA GDSC2; CTRP2 -3.4693 72.0746 -35.1996 51.0921
GMS-10 CTRP2 -3.331 63.3786 -30.7673 51.5318
LN-18 GDSC2 -3.318 2.7439 -4.616 38.1857
M059J GDSC2 -3.2107 1.8829 -4.1517 36.1874
U-87MG ATCC GDSC2 -3.0763 1.3261 -3.794 34.157
LN-405 GDSC2 -2.6791 3.2056 -4.1556 33.5882
D-502MG GDSC2 -2.2148 3.043 -3.6115 29.3183
SW1088 GDSC2 -2.2041 4.6264 -4.3343 32.1339
D-247MG GDSC2 -2.0409 4.266 -4.0049 30.2224
GB-1 GDSC2 -1.6322 5.0698 -3.997 28.5585
DBTRG-05MG GDSC2 -1.1784 4.7668 -3.4249 24.3367
KALS-1 GDSC2 -1.128 9.1036 -5.523 31.8651
42-MG-BA GDSC2; CTRP2 -0.9111 39.9641 -17.0115 48.6118
Onda 11 GDSC2 -0.9059 8.8306 -5.1912 30.1866
CAS-1 GDSC2 -0.6789 10.7999 -5.9756 31.6669
Becker GDSC2; CTRP2 -0.3852 212.5485 -102.6134 49.5939
D-245MG GDSC2 -0.273 7.1354 -3.7977 22.9924
LN-229 GDSC2 -0.1539 9.8342 -5.0459 27.411
KNS-81-FD GDSC2 0.1339 6.1747 -2.9765 17.7678
A-172 GDSC2; CTRP2 0.5422 17.0732 -4.5305 42.4423
YKG-1 GDSC2; CTRP2 0.8029 101.3598 -46.0488 48.4949
KINGS-1 GDSC2 0.9335 11.0106 -4.748 23.3672
NMC-G1 GDSC2 1.2088 4.089 -1.1463 4.4015
KNS-42 GDSC2; CTRP2 2.6144 17.9487 -2.9622 35.5786
GOS-3 CTRP2 2.7348 152.6843 -70.0515 48.4651
U-118MG GDSC2; CTRP2 3.6553 19.9059 -2.9658 33.2838
SW1783 CTRP2 5.7504 25.1997 -3.7794 31.622
KG-1-C CTRP2 7.3082 8.5644 5.6176 0.3962
T98G GDSC2; CTRP2 8.1948 48.2162 -13.2773 36.611
U-251MG GDSC2; CTRP2 8.2294 53.6858 -15.9809 38.0695
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 -3.9272 0.7743 -4.5198 41.3471
TGBC24TKB GDSC2 -1.8263 4.6064 -3.9588 29.1654
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-1 CTRP2 -6.5853 -6.1428 -6.5853 84.1406
JHUEM-7 CTRP2 -6.4974 -4.9927 -6.4974 83.4326
AN3-CA GDSC2; CTRP2 -6.4614 -4.4779 -6.4614 78.0004
EN GDSC2; CTRP2 -6.236 -3.2527 -6.2363 76.1809
ESS-1 GDSC2; CTRP2 -5.3154 5.9089 -6.3162 63.4432
RL95-2 GDSC2 -5.2453 -2.9545 -5.2588 52.5927
JHUEM-3 CTRP2 -5.0583 28.9888 -15.619 55.6694
MFE-319 GDSC2; CTRP2 -3.8568 5.0133 -4.4979 58.9089
KLE GDSC2 -1.9329 6.2952 -4.8746 32.8237
MFE-280 GDSC2 -1.7655 5.5251 -4.3434 30.4028
HEC-1-A CTRP2 -1.4425 105.9041 -50.2541 49.9907
MFE-296 GDSC2; CTRP2 -0.6249 6.9766 -1.5084 43.1879
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-1 CTRP2 -5.9894 -5.0234 -5.9894 80.1676
KTCTL-140 GDSC2 -5.7324 -2.3515 -5.8049 56.9369
SW13 GDSC2 -5.632 -4.5537 -5.632 56.5169
RXF 393L GDSC2 -5.5207 -2.1497 -5.6025 54.9896
KMRC-3 CTRP2 -5.4727 -3.2283 -5.4727 76.5096
KTCTL-13 GDSC2 -5.1867 -3.7984 -5.1871 52.048
KTCTL-195 GDSC2 -5.0367 -1.0166 -5.2562 50.4766
NCC010 GDSC2 -4.5459 -1.6505 -4.627 45.8168
UO-31 GDSC2; CTRP2 -4.5418 -1.516 -4.5431 65.9629
KTCTL-26A GDSC2 -4.3874 0.1486 -4.8295 45.0197
KTCTL-1M GDSC2 -4.3241 -1.2761 -4.4418 43.7594
A-704 GDSC2 -4.1994 0.3991 -4.6979 43.4958
786-O GDSC2; CTRP2 -3.9233 -1.3311 -3.9238 62.219
769-P GDSC2 -3.591 1.7323 -4.4983 39.3218
HA7-RCC GDSC2 -3.2932 4.0389 -5.152 39.4039
KTCTL-21 GDSC2 -3.121 0.9801 -3.7163 34.0712
SW156 GDSC2 -2.9633 2.9462 -4.3337 35.5522
BFTC-909 GDSC2 -2.9011 3.9202 -4.7009 36.387
LB996-RCC GDSC2 -2.8539 3.8639 -4.6278 35.9532
BB65-RCC GDSC2 -2.529 3.1804 -3.9916 32.2868
LB2241-RCC GDSC2 -2.4667 3.1318 -3.9066 31.6719
VMRC-RCW GDSC2 -1.93 5.0074 -4.2504 30.7093
KMRC-20 GDSC2 -1.8566 6.7776 -5.0378 33.0236
TK-10 GDSC2 -1.3275 10.2008 -6.245 34.2952
LB1047-RCC GDSC2 -1.2124 4.8424 -3.4934 24.7841
SN12C GDSC2 -0.9379 9.1439 -5.3753 30.8363
OS-RC-2 GDSC2 -0.0884 12.4722 -6.3099 30.8261
CAL-54 GDSC2; CTRP2 0.4874 16.6053 -4.3648 42.4504
NCC021 GDSC2 0.5962 8.4104 -3.7192 20.0849
VMRC-RCZ GDSC2; CTRP2 2.7075 17.1159 -2.4699 34.5867
A-498 GDSC2; CTRP2 4.2961 25.2563 -5.0548 34.9557
ACHN GDSC2; CTRP2 6.2142 22.4316 -2.0081 26.5476
RCC10RGB GDSC2; CTRP2 6.3777 29.1223 -5.218 31.6622
Caki-2 CTRP2 6.7259 46.5033 -13.62 39.0325
TUHR14TKB CTRP2 7.9751 11.1596 4.8602 2.2614
Caki-1 GDSC2; CTRP2 8.6854 10.2944 5.5269 0.1225
KMRC-2 CTRP2 9.3347 58.9921 -17.7399 38.381
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-C1 GDSC2; CTRP2 -7.0664 -2.8175 -7.0708 79.4729
GP2d CTRP2 -6.378 -5.0959 -6.378 82.7137
KM12 GDSC2 -5.8603 -2.0682 -5.9723 57.8443
SW620 GDSC2 -5.6643 -4.1492 -5.6646 56.8297
DiFi GDSC2 -5.6003 -2.0161 -5.7024 55.6299
SNU-175 GDSC2 -5.5944 -2.4697 -5.649 55.7712
HT-29 GDSC2 -5.5812 -0.254 -6.0235 54.634
NCI-H508 GDSC2 -5.5376 -0.8299 -5.8386 54.5701
HCC2998 GDSC2 -5.5269 -1.9741 -5.6296 54.9759
GP5d GDSC2 -5.5178 -4.5521 -5.5178 55.3717
HT-55 GDSC2 -5.453 -3.0487 -5.4679 54.6197
RKO GDSC2 -5.4466 -0.806 -5.7449 53.8479
SNU-283 GDSC2 -5.4074 -3.3723 -5.4128 54.2232
COLO 320 CTRP2 -5.2459 -2.9436 -5.246 75.0202
HCT 116 GDSC2 -5.1652 -2.1746 -5.2251 51.7413
SNU-C4 CTRP2 -5.1573 -3.7037 -5.1573 74.6135
SNU-1033 CTRP2 -4.977 26.3338 -14.2939 56.0017
SNU-503 CTRP2 -4.8977 20.2788 -11.438 57.1934
CCK-81 GDSC2 -4.8276 -2.9514 -4.8336 48.4548
COLO 320HSR GDSC2 -4.7619 -3.5261 -4.7621 47.7868
HCT 15 GDSC2; CTRP2 -4.611 -1.7772 -4.6117 66.4335
MDST8 GDSC2 -4.3525 0.657 -4.9444 44.9671
SNU-1040 GDSC2 -4.2991 -1.5198 -4.3809 43.4161
LS411N GDSC2 -4.1618 1.7578 -5.1192 44.025
SNU-C2B GDSC2 -4.1496 1.0266 -4.8454 43.4673
T84 GDSC2; CTRP2 -3.9454 -0.1227 -3.9566 62.0982
SNU-C5 GDSC2 -3.8741 1.105 -4.574 41.1622
NCI-H716 GDSC2; CTRP2 -3.7136 2.4317 -3.8793 59.7013
C2BBe1 GDSC2; CTRP2 -3.6952 27.7363 -13.699 52.9519
SW1463 GDSC2 -3.6238 1.5881 -4.479 39.4519
CW-2 GDSC2 -2.992 -0.853 -3.0782 30.4596
LS180 GDSC2 -2.722 1.0302 -3.3042 30.2396
LS513 GDSC2 -2.6861 1.8069 -3.566 31.266
NCI-H747 GDSC2; CTRP2 -2.6545 11.4309 -5.317 52.401
HT115 GDSC2 -2.6071 2.2424 -3.6633 31.3142
COLO205 GDSC2 -2.5916 2.7289 -3.8562 32.0415
SNU-81 GDSC2 -2.5692 1.8765 -3.4713 30.2905
SNU-407 GDSC2 -2.5676 0.6989 -3.0199 28.1049
LoVo GDSC2 -2.4341 4.0195 -4.2776 32.9184
HCC-56 CTRP2 -2.4153 13.7318 -6.0173 52.9886
SW48 GDSC2 -2.3417 8.4193 -6.2912 37.804
SW626 GDSC2 -2.274 4.0307 -4.1239 31.6635
SW837 GDSC2 -1.8471 5.1856 -4.2568 30.4034
CaR-1 GDSC2 -1.5216 6.0492 -4.3705 29.5771
LS1034 GDSC2; CTRP2 -1.351 6.2103 -2.0724 46.8743
SW948 GDSC2; CTRP2 -1.0534 10.6081 -3.2934 46.3934
SNU-61 GDSC2 -0.7028 7.3101 -4.2561 26.284
CL-11 GDSC2 -0.4926 5.4503 -3.1459 20.5922
RCM-1 [Human ESC] GDSC2; CTRP2 -0.1659 25.7238 -9.3523 46.3391
HCT 8 CTRP2 0.0906 8.7577 -1.3535 42.3924
SW1417 GDSC2; CTRP2 0.1003 10.7254 -2.127 41.3282
SW1116 GDSC2 0.4464 6.6406 -2.956 16.7625
COLO 678 GDSC2; CTRP2 0.6218 15.9608 -3.9314 41.718
SK-CO-1 GDSC2 1.5535 3.6212 -0.7385 1.6577
LS123 GDSC2 1.6679 15.3828 -6.3494 26.5745
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 0.5602 5.8132 -2.4539 13.6906
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLF CTRP2 -11.2278 23.3393 -19.2688 64.7865
PLC/PRF/5 CTRP2 -10.3032 10.7328 -13.2655 70.7167
SNU-398 GDSC2 -6.7547 -4.8739 -6.7553 67.5876
JHH-1 GDSC2; CTRP2 -5.9516 -5.2939 -5.9516 74.9311
SK-HEP-1 GDSC2; CTRP2 -5.8825 17.6236 -11.2782 58.676
HLE GDSC2 -5.5292 -2.7877 -5.5585 55.2812
Hep 3B2.1-7 GDSC2 -5.4898 -2.1419 -5.5706 54.7115
JHH-2 GDSC2; CTRP2 -5.1968 21.6031 -12.3372 56.3717
SNU-423 GDSC2; CTRP2 -5.1187 -3.5921 -5.1187 69.724
JHH-6 GDSC2; CTRP2 -4.2241 -1.2451 -4.2255 64.0229
SNU-475 CTRP2 -4.1604 14.5907 -8.1978 57.3846
SNU-387 GDSC2; CTRP2 -3.9764 7.4611 -5.3089 58.0797
JHH-7 GDSC2 -3.0908 2.4881 -4.2715 35.9777
JHH-4 GDSC2; CTRP2 -2.8658 0.9532 -2.8863 55.5391
HuH-1 GDSC2; CTRP2 -1.7678 18.7447 -7.5922 49.514
Hep-G2/C3A GDSC2 0.2352 9.6164 -4.6136 24.7744
SNU-449 GDSC2; CTRP2 1.0407 12.7662 -2.0457 38.279
Huh-7 GDSC2 1.3277 11.8345 -4.8505 22.738
JHH-5 CTRP2 8.6432 82.3286 -29.9542 42.5546
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 189 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2170 GDSC2; CTRP2 -11.6838 26.1656 -20.9719 63.5241
NCI-H1341 CTRP2 -11.1993 6.5895 -12.9258 75.5994
NCI-H146 GDSC2; CTRP2 -11.0053 14.9965 -15.5926 67.6479
LUDLU-1 CTRP2 -10.8567 8.8951 -13.2507 72.9604
NCI-H322 CTRP2 -10.8347 11.5394 -14.1233 70.7522
HCC4006 CTRP2 -8.1861 18.6984 -14.1272 63.0282
NCI-H810 GDSC2; CTRP2 -8.0065 -4.2226 -8.0075 84.7775
DV-90 CTRP2 -7.7261 -4.6303 -7.7262 88.4841
COR-L88 CTRP2 -7.1423 0.2848 -7.2763 77.9578
NCI-H520 GDSC2; CTRP2 -7.098 -3.7221 -7.0986 80.7126
COR-L279 CTRP2 -7.0602 -5.7941 -7.0602 87.1667
NCI-H1915 GDSC2; CTRP2 -6.9803 22.2952 -14.4553 59.048
NCI-H82 GDSC2 -6.9522 -4.3691 -6.9585 68.9218
NCI-H1568 GDSC2; CTRP2 -6.8466 -4.7992 -6.8466 80.3197
KNS-62 GDSC2; CTRP2 -6.5847 25.95 -15.7127 57.5658
NCI-H1105 GDSC2; CTRP2 -6.5635 -4.2578 -6.5635 78.5015
SCLC-21H CTRP2 -6.3556 -5.1046 -6.3556 82.5718
DMS 273 GDSC2; CTRP2 -6.3047 -5.3832 -6.3047 77.1358
NCI-H23 GDSC2; CTRP2 -6.2756 -2.5741 -6.2778 75.8454
LK2 CTRP2 -6.2433 1.7885 -6.4885 73.2306
HCC1438 CTRP2 -6.241 5.3603 -7.1826 68.6593
NCI-H2171 GDSC2; CTRP2 -6.1894 -3.4519 -6.1896 76.0497
NCI-H522 GDSC2; CTRP2 -6.1755 -4.0034 -6.1755 76.1974
Ms-1 GDSC2 -6.1391 -3.2165 -6.1652 61.0066
COR-L321 GDSC2 -6.0494 -4.3209 -6.0501 60.6558
RERF-LC-MS GDSC2; CTRP2 -6.0481 -5.1403 -6.0481 75.5332
SBC-3 GDSC2 -6.044 -1.7768 -6.2096 59.0711
SK-MES-1 GDSC2; CTRP2 -6.0357 -4.8538 -6.0357 75.4542
NCI-H1703 CTRP2 -6.0078 -5.1519 -6.0078 80.2923
NCI-H1339 CTRP2 -5.9979 -5.0543 -5.9979 80.2247
NCI-H290 GDSC2 -5.9369 -4.7504 -5.937 59.5748
NCI-H2110 GDSC2; CTRP2 -5.9263 -4.442 -5.9263 74.7622
NCI-H748 GDSC2 -5.8883 -2.6607 -5.9407 58.4633
DMS 114 GDSC2; CTRP2 -5.8691 -4.8878 -5.8691 74.415
NCI-H1437 GDSC2 -5.8178 -2.4028 -5.8897 57.7008
NCI-H460 GDSC2 -5.8125 -4.6895 -5.8125 58.3276
EMC-BAC-2 GDSC2 -5.8029 -3.2316 -5.8193 57.9848
HARA [Human squamous cell lung carcinoma] GDSC2 -5.7857 -4.7156 -5.7857 58.0588
NCI-H1581 GDSC2 -5.7623 -2.8147 -5.7983 57.4327
EPLC-272H GDSC2 -5.759 -3.6235 -5.7642 57.6903
NCI-H1734 GDSC2 -5.7139 -4.2493 -5.7141 57.3292
COR-L51 CTRP2 -5.6956 0.806 -5.8055 72.9439
Lu-134-A GDSC2 -5.6551 -0.6118 -6.0159 55.3527
HCC78 GDSC2 -5.645 -1.5473 -5.8175 55.7732
LC-1/sq-SF CTRP2 -5.6439 22.7593 -13.3119 57.8077
NCI-H838 GDSC2; CTRP2 -5.6226 -4.5274 -5.6226 72.8755
NCI-H209 GDSC2 -5.5975 -2.3528 -5.6627 55.7518
NCI-H524 GDSC2 -5.5139 -2.6932 -5.5484 55.1108
NCI-H1792 GDSC2 -5.5132 -3.6541 -5.5157 55.2941
NCI-H526 GDSC2 -5.4885 -3.814 -5.4896 55.0617
NCI-H2795 GDSC2 -5.4792 -3.6689 -5.4813 54.9592
NCI-H1770 GDSC2 -5.4675 -2.7135 -5.4991 54.6831
NCI-H292 GDSC2 -5.4355 -3.457 -5.4398 54.5086
LB647-SCLC GDSC2 -5.4333 -2.5292 -5.476 54.3164
NCI-H446 GDSC2 -5.4295 -2.2953 -5.4915 54.2166
SBC-5 GDSC2 -5.4205 -3.8263 -5.4213 54.3856
NCI-H1869 GDSC2; CTRP2 -5.3972 13.2453 -8.9456 59.3342
NCI-H2122 GDSC2 -5.3929 -4.3978 -5.3929 54.1182
A-549 GDSC2 -5.358 -1.3708 -5.5382 53.3105
LXF 289 GDSC2 -5.3409 -1.4351 -5.5089 53.1829
PC-14 GDSC2 -5.3261 -2.6537 -5.3562 53.3338
HCC33 GDSC2 -5.2392 -3.4524 -5.2418 52.5643
NCI-H211 GDSC2 -5.1907 -3.5428 -5.1921 52.0833
ChaGo-K-1 GDSC2; CTRP2 -5.1571 -3.0172 -5.1571 69.9247
A-427 GDSC2 -5.1542 -2.9577 -5.1657 51.6995
COR-L311 GDSC2 -5.1403 -2.6938 -5.1621 51.5472
NCI-H2081 GDSC2; CTRP2 -5.1268 1.2407 -5.2471 67.0349
SHP-77 GDSC2 -5.1243 -1.2872 -5.3008 51.2675
IST-SL1 GDSC2 -5.0133 -0.2532 -5.4042 50.2526
NCI-H1623 GDSC2; CTRP2 -5.013 -0.969 -5.022 68.3416
NCI-H1694 GDSC2; CTRP2 -4.9951 -2.9137 -4.9951 68.9251
NCI-H2810 GDSC2 -4.9607 -0.7788 -5.2228 49.8112
COR-L303 GDSC2 -4.9562 -0.991 -5.1741 49.7674
NCI-H596 GDSC2 -4.9062 -2.8824 -4.9151 49.2411
EMC-BAC-1 GDSC2 -4.821 -1.8949 -4.8905 48.4547
NCI-H1944 GDSC2; CTRP2 -4.7943 26.2857 -14.0914 54.8642
NCI-H2029 GDSC2; CTRP2 -4.7662 -1.4257 -4.7687 67.2287
LCLC-103H GDSC2 -4.7524 -1.0819 -4.9362 47.914
HCC827 GDSC2 -4.7425 -3.0723 -4.7455 47.5989
COLO 668 GDSC2; CTRP2 -4.7265 -0.9551 -4.7329 66.8034
NCI-H1651 GDSC2; CTRP2 -4.7213 -0.8896 -4.7285 66.7429
NCI-H322M GDSC2 -4.6056 0.4811 -5.1654 47.0078
NCI-H841 GDSC2; CTRP2 -4.5643 -3.0982 -4.5643 66.2638
NCI-H1563 GDSC2; CTRP2 -4.5247 1.0686 -4.6036 64.4929
LOU-NH91 GDSC2 -4.506 -1.8999 -4.5579 45.3626
RERF-LC-Ad2 CTRP2 -4.4843 82.3393 -41.1972 51.9063
DMS 79 GDSC2 -4.46 -0.7115 -4.6931 45.2998
NCI-H1963 GDSC2 -4.388 0.237 -4.8555 45.067
RERF-LC-KJ GDSC2 -4.3638 -1.8909 -4.4095 43.9453
UMC-11 GDSC2 -4.2723 0.0413 -4.6738 43.9349
NCI-H2818 GDSC2 -4.2564 0.3499 -4.7452 43.9701
NCI-H647 GDSC2; CTRP2 -4.1791 16.0852 -8.8538 55.6406
NCI-H1436 GDSC2 -4.1574 -0.5272 -4.4048 42.5221
NCI-H510A GDSC2 -4.1465 0.3048 -4.612 42.9613
CPC-N GDSC2 -4.0886 -0.0433 -4.4503 42.1889
NCI-H1048 GDSC2 -4.077 -0.53 -4.3166 41.743
HCC366 GDSC2 -4.042 0.9351 -4.6978 42.4846
NCI-H2869 GDSC2 -3.9725 1.1922 -4.7108 42.0839
DMS 53 GDSC2; CTRP2 -3.9507 -1.4931 -3.9509 62.401
LCLC-97TM1 GDSC2 -3.915 1.2733 -4.6774 41.6593
NCI-H1781 GDSC2 -3.8943 1.1556 -4.6135 41.3819
NCI-H1299 GDSC2 -3.8701 -0.1584 -4.1813 40.0168
NCI-H1975 GDSC2 -3.858 -0.1466 -4.1712 39.9099
NCI-H661 GDSC2 -3.8399 -0.3193 -4.1079 39.5871
NCI-H650 GDSC2 -3.8005 1.2246 -4.5365 40.6276
NCI-H1993 GDSC2 -3.776 -0.0048 -4.1196 39.241
NCI-H2023 GDSC2 -3.6632 -0.2318 -3.9369 37.9195
Lu-65 GDSC2; CTRP2 -3.6619 6.4419 -4.6595 57.4135
NCI-H2803 GDSC2 -3.6495 -0.6514 -3.8257 37.4025
NCI-H358 GDSC2 -3.6431 3.0335 -5.0771 41.007
NCI-H1155 GDSC2 -3.6156 0.8765 -4.2157 38.6152
LC-1/sq GDSC2 -3.601 0.9342 -4.2196 38.5441
LK-2 GDSC2 -3.5839 3.5219 -5.2235 40.9992
ABC-1 GDSC2 -3.4134 1.6961 -4.2948 37.7381
NCI-H2227 GDSC2 -3.2816 4.2751 -5.2458 39.5553
NCI-H1355 GDSC2 -3.2341 3.2663 -4.7517 38.1309
NCI-H1876 GDSC2 -3.163 1.0273 -3.7784 34.5437
Lu-139 GDSC2 -3.1029 1.4815 -3.881 34.6373
NCI-H1395 CTRP2 -2.9959 6.2813 -3.8872 57.2301
RERF-LC-Sq1 GDSC2 -2.9465 1.8106 -3.8428 33.6944
NCI-H3255 GDSC2 -2.8857 4.6648 -5.0249 37.2
EKVX GDSC2; CTRP2 -2.8065 9.9199 -4.8939 53.1606
NCI-H2804 GDSC2 -2.7626 5.6506 -5.3628 37.4915
NCI-H3122 GDSC2 -2.705 4.5457 -4.7901 35.7533
BEN GDSC2 -2.6481 2.8472 -3.966 32.7362
NCI-H1092 GDSC2; CTRP2 -2.6313 6.8999 -3.6704 53.045
EBC-1 GDSC2 -2.5054 4.4449 -4.5454 34.1315
Calu-6 GDSC2 -2.4786 6.0512 -5.2771 36.1043
SK-LU-1 GDSC2 -2.4109 5.3497 -4.8777 34.7426
VMRC-LCD GDSC2; CTRP2 -2.2568 5.043 -2.7624 51.5461
NCI-H1666 GDSC2 -2.1661 4.1378 -4.0674 30.9892
COR-L95 CTRP2 -2.1565 20.6941 -8.8807 51.6031
NCI-H2030 GDSC2 -2.1026 3.7379 -3.8181 29.7226
NCI-H2172 GDSC2 -2.0696 4.8459 -4.3077 31.483
LC-2/ad GDSC2 -2.0404 5.0518 -4.3777 31.6133
Lu-99A GDSC2 -2.0351 8.854 -6.2195 36.5791
NCI-H2196 GDSC2; CTRP2 -2.0234 3.4045 -2.2051 50.3646
COR-L105 GDSC2; CTRP2 -1.9028 26.2413 -11.2554 49.8913
SBC-1 GDSC2 -1.7885 4.2267 -3.7412 28.1042
NCI-H2087 GDSC2 -1.7575 3.4943 -3.3644 26.2684
CAL-12T GDSC2 -1.7559 4.0912 -3.6452 27.5543
NCI-H2342 CTRP2 -1.7382 49.8078 -22.6192 50.2932
NCI-H2373 GDSC2 -1.597 5.3389 -4.0944 28.8125
NCI-H2228 GDSC2 -1.4967 7.3897 -5.0059 31.6166
NCI-H2141 GDSC2; CTRP2 -1.4723 7.1755 -2.4935 47.6585
NCI-H740 GDSC2 -1.4663 8.9467 -5.7473 33.5682
HCC44 GDSC2 -1.4089 6.2253 -4.3528 29.0975
SW1271 GDSC2 -1.2709 5.4836 -3.8617 26.6424
NCI-H2461 GDSC2 -0.9545 6.9537 -4.3012 27.3015
NCI-H1836 GDSC2 -0.6801 5.9257 -3.5471 23.1726
NCI-H196 GDSC2 -0.6581 6.0072 -3.5682 23.197
NCI-H2369 GDSC2 -0.5148 6.2473 -3.5624 22.6975
NCI-H1755 GDSC2 -0.4445 16.1627 -8.4547 35.8904
COR-L23 GDSC2 -0.3395 11.073 -5.8219 30.2707
NCI-H2731 GDSC2 -0.3114 7.1592 -3.8423 23.3092
NCI-H513 GDSC2 -0.2577 10.6156 -5.5241 29.1976
Calu-3 GDSC2 -0.2518 11.1682 -5.7953 29.9471
T3M-10 CTRP2 -0.0908 180.9633 -86.5789 49.5847
NCI-H250 GDSC2 0.2055 12.1656 -5.9124 28.9996
NCI-H1650 GDSC2 0.2988 12.0495 -5.7776 28.3735
NCI-H2085 GDSC2 0.3169 13.8609 -6.6681 30.6183
COR-L32 GDSC2 0.3313 6.3081 -2.8824 16.6966
IST-SL2 GDSC2 0.3853 9.068 -4.217 22.8119
NCI-H1693 GDSC2; CTRP2 0.4171 20.2388 -6.1543 43.8418
NCI-H441 GDSC2 0.6605 11.8458 -5.3819 26.2302
Lu-135 GDSC2 0.6771 6.755 -2.8312 15.465
NCI-H1435 GDSC2 0.7169 7.6343 -3.2374 17.4615
NCI-H2595 GDSC2 0.74 9.0362 -3.9172 20.5705
Lu-165 GDSC2 0.9334 13.5958 -6.0365 27.4637
HOP-62 GDSC2; CTRP2 0.939 60.8807 -25.7365 47.3644
NCI-H2135 GDSC2 1.001 9.0336 -3.7121 18.9659
DMS 454 CTRP2 1.2091 24.1136 -7.28 43.8896
NCI-H2291 GDSC2 1.297 8.3869 -3.1677 15.6139
NCI-H720 GDSC2 1.3103 13.2674 -5.5759 25.1956
NCI-H2405 GDSC2 1.3601 11.2829 -4.5519 21.5514
NCI-H727 GDSC2 1.383 11.3878 -4.5864 21.6262
NCI-H2591 GDSC2 1.4303 10.0061 -3.8668 18.5673
SW1573 GDSC2 1.4357 7.9103 -2.8318 13.5511
NCI-H2444 GDSC2 1.5317 4.0724 -0.9458 2.7354
NCI-H345 GDSC2 1.6059 10.291 -3.8762 18.1806
HCC15 GDSC2 1.9904 15.6921 -6.2553 25.5987
NCI-H2722 GDSC2 2.1821 17.8921 -7.1989 27.5659
NCI-H226 GDSC2 3.2691 18.8153 -6.8417 24.5167
IA-LM GDSC2; CTRP2 7.7022 21.0166 -0.109 19.4146
HCC2935 CTRP2 10.3808 39.9845 -7.4611 29.7737
Calu-1 CTRP2 11.0011 54.9848 -14.4276 35.0791
HOP-92 GDSC2; CTRP2 11.1931 35.9882 -4.8834 24.5394
NCI-H1793 GDSC2; CTRP2 11.3332 29.9982 -1.8626 18.6348
Hs 888.Lu CTRP2 5.8138 52.9073 -17.5794 41.6779
⏷ Show the Full List of 189 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 -2.3652 4.0275 -4.2129 32.386
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 -10.6227 11.5243 -13.8891 70.5053
Yamato-SS CTRP2 -5.6973 -2.8196 -5.6977 77.535
Tm87-16 CTRP2 -12.1931 7.2209 -14.1921 76.0068
TTC-709 CTRP2 -12.1306 7.2424 -14.1302 75.9232
TE 617.T CTRP2 -7.8401 -6.33 -7.8401 91.6869
BT-16 CTRP2 -7.8301 14.614 -12.0681 64.5127
G-402 GDSC2; CTRP2 -7.4666 -4.508 -7.4667 83.1723
TE 441.T GDSC2; CTRP2 -7.3485 -5.5243 -7.3485 83.4391
MES-SA GDSC2; CTRP2 -6.3958 -6.0617 -6.3958 77.7055
G-401 GDSC2; CTRP2 -6.2407 -3.6554 -6.2408 76.4332
BT-12 CTRP2 -6.0542 -5.6064 -6.0542 80.6027
STS-0421 GDSC2 -5.9467 -4.1852 -5.9477 59.6272
Rh41 GDSC2 -5.4575 -3.3032 -5.4649 54.7052
RD GDSC2; CTRP2 -5.2168 -0.3649 -5.2436 68.9055
Rh30 GDSC2 -5.113 -2.1912 -5.1687 51.2488
Hs 729.T CTRP2 -4.6054 20.2021 -11.1075 56.679
SW982 GDSC2; CTRP2 -4.201 3.6314 -4.5824 61.1874
GCT GDSC2; CTRP2 -4.0126 1.8253 -4.1306 61.5135
EW-8 GDSC2 -3.9681 -0.6782 -4.166 40.5745
SK-UT-1 GDSC2; CTRP2 -3.6258 42.977 -20.9918 51.9392
VA-ES-BJ GDSC2 -1.8439 5.8195 -4.5601 31.4667
KYM-1 GDSC2; CTRP2 -1.513 168.8443 -81.736 49.8559
A-204 GDSC2; CTRP2 -0.8649 9.5282 -2.6683 45.2963
HT-1080 GDSC2; CTRP2 -0.6097 5.6377 -1.1106 42.5474
SW872 GDSC2 -0.3532 6.6246 -3.611 22.4025
RKN GDSC2 0.1865 8.8602 -4.2757 23.617
SK-LMS-1 GDSC2; CTRP2 0.3486 173.367 -82.4095 49.2676
SW684 GDSC2 1.2909 14.326 -6.1177 26.821
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -7.6063 8.5474 -9.6048 68.4205
OC 314 CTRP2 -16.3441 4.2117 -17.9139 82.0988
JHOM-1 CTRP2 -8.2143 19.1769 -14.3602 62.8622
COV644 CTRP2 -6.8815 -4.8267 -6.8815 85.4774
COV434 CTRP2 -6.3493 -5.2267 -6.3493 82.5481
JHOS-4 GDSC2 -6.2767 -2.4708 -6.3668 61.4921
TOV-112D GDSC2; CTRP2 -6.0279 -3.526 -6.028 75.1873
OVK18 GDSC2 -5.8243 -4.8663 -5.8243 58.4468
A2780 GDSC2 -5.6736 -3.2948 -5.685 56.7879
COV362 CTRP2 -5.0991 23.4737 -13.0915 56.7663
Caov-3 GDSC2 -4.3748 0.6716 -4.9733 45.1623
OVCAR-8 GDSC2 -4.1695 0.1442 -4.5905 43.0638
TOV-21G GDSC2; CTRP2 -4.0758 8.534 -5.7679 57.9073
DOV13 GDSC2 -3.7168 0.8573 -4.319 39.5244
IGROV-1 GDSC2 -2.9843 3.0701 -4.4092 35.8987
OAW42 GDSC2; CTRP2 -2.5386 2.2551 -2.6223 53.4303
OVISE GDSC2 -2.042 5.0786 -4.392 31.6702
TYK-nu GDSC2 -1.2796 4.4774 -3.3777 24.4832
OVCAR-3 GDSC2 -1.1647 6.6895 -4.3589 28.2469
OVTOKO GDSC2 -1.047 9.0546 -5.427 31.3348
ES-2 GDSC2 -0.9025 9.4077 -5.4756 31.0107
OVCAR-4 GDSC2 -0.9024 5.7258 -3.6458 24.3837
OAW28 GDSC2; CTRP2 -0.8919 6.8585 -1.7624 44.5909
OVCAR-5 GDSC2; CTRP2 -0.63 572.4099 -282.7194 49.8725
SK-OV-3 GDSC2 -0.443 9.5391 -5.1435 28.5907
EFO-27 GDSC2; CTRP2 -0.1545 230.036 -111.1582 49.5693
EFO-21 GDSC2; CTRP2 -0.0964 24.5582 -8.7223 46.0229
OV7 CTRP2 -0.0447 75.5954 -33.9273 48.9759
Kuramochi GDSC2 0.1713 8.8829 -4.2995 23.7557
OV56 GDSC2; CTRP2 0.4519 18.8408 -5.4541 43.3346
JHOS-2 GDSC2; CTRP2 2.0301 47.7819 -18.2574 45.2811
OV-90 GDSC2; CTRP2 6.758 43.0544 -11.8694 37.3345
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 -6.3211 -1.1366 -6.346 78.0281
H-STS CTRP2 -6.2915 -5.8704 -6.2915 82.1835
SYO-1 CTRP2 -1.1249 205.4659 -99.702 49.9108
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 4.9167 41.4272 -12.5953 40.6736
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JL-1 CTRP2 -5.1376 -1.6833 -5.1401 73.625
MSTO-211H GDSC2 -4.7231 -0.1217 -5.1218 47.8393
MPP 89 GDSC2; CTRP2 -4.6394 3.8494 -5.0976 62.7849
NCI-H28 GDSC2 -0.9441 9.2075 -5.4124 30.9629
NCI-H2052 GDSC2 1.2553 11.0841 -4.5339 21.7443
IST-Mes1 GDSC2; CTRP2 2.8736 19.7807 -3.6171 35.9297
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2; CTRP2 -6.2246 -4.9131 -6.2246 76.629
LNCaP clone FGC GDSC2; CTRP2 -5.6173 9.0238 -7.6047 62.0627
22Rv1 GDSC2 -3.485 1.843 -4.4278 38.5338
PC-3 GDSC2 -2.1584 5.9569 -4.9248 33.8539
NCI-H660 GDSC2; CTRP2 0.0892 11.8555 -2.6176 41.9478
DU145 GDSC2; CTRP2 4.5558 29.5032 -6.9474 36.5445
PaCa-3 CTRP2 7.8142 48.0035 -13.4792 37.7489
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2; CTRP2 -8.8278 27.502 -18.6706 60.0494
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 -5.1386 -3.4172 -5.1408 51.561
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LMSU CTRP2 -11.7995 16.1739 -16.897 68.7929
MKN74 CTRP2 -10.4811 7.3187 -12.3539 74.0006
SNU-16 CTRP2 -8.8722 -7.3719 -8.8722 96.5244
NCC-StC-K140 CTRP2 -8.6625 9.1229 -10.9407 69.7224
SNU-601 CTRP2 -8.4515 45.9204 -26.9678 56.9638
SNU-1 GDSC2; CTRP2 -7.7537 0.4542 -7.9351 76.4859
AGS GDSC2 -7.4171 -1.4141 -7.7569 67.0915
SNU-216 CTRP2 -7.2799 26.445 -16.635 59.1903
IM95 GDSC2; CTRP2 -6.56 -3.1019 -6.561 77.6649
HGC-27 GDSC2; CTRP2 -6.515 -4.0599 -6.515 78.1387
SH-10-TC CTRP2 -6.3501 -5.1448 -6.3501 82.5432
RF-48 GDSC2 -6.0887 -1.3406 -6.3326 59.0225
HuG1-N CTRP2 -5.7557 6.0406 -6.8324 66.7057
TMK-1 GDSC2 -5.7009 -4.2021 -5.7012 57.1974
SNU-5 GDSC2 -5.6244 -0.4708 -6.0162 55.0542
ECC10 GDSC2 -5.5358 -3.2837 -5.545 55.463
SK-GT-2 GDSC2 -5.466 -1.9542 -5.5673 54.4351
SCH GDSC2 -5.3044 -3.7417 -5.3052 53.2244
MKN45 GDSC2 -5.1556 1.9559 -6.26 51.1233
GCIY GDSC2 -4.7811 0.6326 -5.4033 48.4514
Hs 746.T GDSC2; CTRP2 -4.7691 17.9875 -10.2893 56.4274
NCI-N87 GDSC2 -4.7181 0.5492 -5.3089 47.938
23132/87 GDSC2 -4.537 -0.8533 -4.7472 45.9688
RERF-GC-1B GDSC2 -4.5091 0.8271 -5.1693 46.3362
ECC12 GDSC2 -4.4191 -0.0349 -4.8133 45.2156
MKN28 GDSC2 -4.3047 -0.0109 -4.6949 44.1994
NUGC-3 GDSC2 -4.239 2.1279 -5.3418 44.8211
MKN1 GDSC2 -3.779 1.4703 -4.6019 40.6699
OCUM-1 GDSC2 -2.6155 7.1495 -5.9346 38.1323
MKN7 GDSC2; CTRP2 -2.5391 13.5473 -6.0676 51.7997
KATO III GDSC2; CTRP2 -0.7408 19.1914 -6.7835 46.8454
NUGC-4 GDSC2 0.0654 8.9283 -4.4098 24.4961
KE-39 CTRP2 9.0856 19.7089 1.5506 13.0029
SNU-685 CTRP2 -5.8687 19.3902 -12.033 59.1587
SNG-M GDSC2 -4.1742 -0.8352 -4.3576 42.5027
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 -7.8072 -5.1057 -7.8073 89.5859
KMH-2 GDSC2 -6.0969 -4.8594 -6.0969 61.177
FTC-238 CTRP2 -5.9736 -4.8864 -5.9736 80.0581
K5 GDSC2 -5.3548 -3.2597 -5.3617 53.695
ASH-3 GDSC2 -4.9164 -0.7331 -5.1845 49.4269
HTC-C3 GDSC2 -4.8422 -1.2593 -5.0015 48.7187
BHT-101 GDSC2 -4.5775 -0.6327 -4.8381 46.4158
IHH-4 GDSC2 -4.2177 0.7564 -4.8297 43.8759
CAL-62 GDSC2 -3.5309 0.1109 -3.8842 36.9606
8505C GDSC2 -3.1747 3.4685 -4.7787 37.9097
B-CPAP GDSC2 -2.8917 5.0402 -5.2045 37.6741
8305C GDSC2 -2.4654 4.7255 -4.6369 34.2483
FTC-133 GDSC2; CTRP2 -1.3822 12.2024 -4.2945 47.943
ML-1 [Human leukemia] GDSC2 -0.2063 7.0812 -3.7139 22.4105
WRO GDSC2 0.2418 12.3505 -5.9749 29.0727
TT2609-C02 GDSC2; CTRP2 2.0708 18.1531 -3.5732 37.6912
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 6 CTRP2 -11.6253 12.8554 -15.4497 70.7083
PE/CA-PJ15 GDSC2; CTRP2 -10.485 9.912 -13.1816 70.4405
BICR 16 CTRP2 -8.4503 8.5969 -10.5382 69.848
PE/CA-PJ49 CTRP2 -7.1576 -4.9866 -7.1576 86.9745
HSC-2 GDSC2; CTRP2 -7.0274 -6.0268 -7.0274 81.6465
PCI-15A GDSC2 -7.0157 -5.3599 -7.0158 70.254
BICR 22 GDSC2; CTRP2 -6.9222 -3.5745 -6.9229 79.7844
PE/CA-PJ34 (clone C12) CTRP2 -6.7134 -5.9701 -6.7134 84.9915
CAL-27 GDSC2; CTRP2 -6.2549 -5.0736 -6.2549 76.8221
UPCI-SCC-090 GDSC2 -6.1422 -3.9239 -6.1468 61.4338
BB30-HNC GDSC2 -5.961 -4.9521 -5.961 59.818
JHU-011 GDSC2 -5.9429 -4.5397 -5.943 59.626
KON GDSC2 -5.9295 -2.1521 -6.0355 58.4676
SAS GDSC2 -5.9077 -3.3501 -5.9221 59.0044
SCC-9 GDSC2; CTRP2 -5.7971 -4.079 -5.7971 73.9421
BICR 56 CTRP2 -5.5685 -4.4289 -5.5685 77.3616
JHU-029 GDSC2 -5.5678 -4.2438 -5.5679 55.8698
PCI-06A GDSC2 -5.4676 -3.3392 -5.4744 54.8087
Detroit 562 GDSC2 -5.4526 -3.9054 -5.4532 54.7086
SCC-4 GDSC2; CTRP2 -5.4164 -1.9868 -5.4184 71.0788
SAT [Human HNSCC] GDSC2 -5.4123 -3.7126 -5.4137 54.2984
HO-1-N-1 GDSC2 -5.3769 -4.2147 -5.3769 53.9566
HSC-3 GDSC2 -5.3654 -4.5446 -5.3654 53.8418
DOK GDSC2 -5.364 -3.5403 -5.3665 53.8083
OSC-19 GDSC2 -5.307 -3.7526 -5.3078 53.2502
PCI-04B GDSC2 -5.2777 -3.811 -5.2782 52.959
CAL-33 GDSC2; CTRP2 -5.2452 -3.1349 -5.2452 70.4745
KOSC-2 GDSC2 -5.1665 -3.3685 -5.1695 51.838
SCC-25 GDSC2 -5.1599 -2.457 -5.1965 51.7194
NCI-H3118 GDSC2 -4.9995 -2.6352 -5.02 50.1675
BICR 18 CTRP2 -4.8583 -1.6429 -4.86 72.0692
LB771-HNC GDSC2 -4.8024 -1.8893 -4.8715 48.2756
SCC-15 GDSC2 -4.729 -0.0241 -5.1543 47.9088
Ca9-22 GDSC2 -4.6132 -2.0593 -4.6563 46.3962
HSC-4 GDSC2 -4.3516 0.0782 -4.7706 44.6675
BHY GDSC2 -3.7973 0.2143 -4.2045 39.6486
BICR 31 GDSC2; CTRP2 -3.698 0.8748 -3.7363 60.3495
SKN-3 GDSC2 -3.6338 0.712 -4.1807 38.6065
BB49-HNC GDSC2 -3.5507 -0.8177 -3.6863 36.2588
BICR 10 GDSC2 -3.2243 6.7249 -6.3203 41.249
JHU-022 GDSC2 -1.565 7.78 -5.2605 32.6085
PE/CA-PJ41 (clone D2) CTRP2 -1.3503 66.5219 -30.5582 49.9111
OSC-20 GDSC2 -1.0484 6.9435 -4.38 27.9215
BICR 78 GDSC2 -0.7425 8.9788 -5.1223 29.4523
FaDu GDSC2; CTRP2 0.1301 45.1593 -18.6369 47.484
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-1 CTRP2 -11.2672 7.1004 -13.1469 75.1501
KMBC-2 CTRP2 -8.6187 35.2554 -22.0525 58.7673
U-BLC1 CTRP2 -8.1407 26.3027 -17.4344 60.3073
KU-19-19 GDSC2 -6.2847 -4.0778 -6.2885 62.8318
SCaBER CTRP2 -6.1679 -4.8409 -6.1679 81.3209
RT-112 GDSC2 -5.6968 -2.9434 -5.7231 56.8905
BFTC-905 GDSC2 -5.3947 -3.6452 -5.3965 54.1197
BC-3C CTRP2 -5.3452 13.0381 -8.8078 60.7284
CAL-29 GDSC2 -5.194 -1.3811 -5.3598 51.894
647V GDSC2; CTRP2 -4.6003 -0.1478 -4.6214 65.6901
HT-1197 GDSC2; CTRP2 -4.5459 1.1682 -4.633 64.5194
RT-4 GDSC2 -4.3585 4.1237 -6.284 46.4454
639V GDSC2 -4.0907 1.521 -4.9557 43.308
SW1710 GDSC2 -3.334 2.7264 -4.6254 38.2942
5637 GDSC2 -2.5341 3.4094 -4.0995 32.7185
SW780 GDSC2 -2.5264 5.141 -4.8918 35.269
TCCSUP GDSC2 -1.9084 3.0521 -3.308 26.6148
J82 GDSC2; CTRP2 0.3829 8.6349 -0.9942 38.6104
T24 GDSC2; CTRP2 5.7543 83.7631 -33.0569 44.6115
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JAR GDSC2 -6.1598 -4.8886 -6.1598 61.8063
NEC8 GDSC2 -5.9037 -4.496 -5.9038 59.2332
DSH1 GDSC2 -5.9003 -4.8005 -5.9003 59.2091
DoTc2 4510 GDSC2 -5.8802 -3.6582 -5.8862 58.861
PA-1 GDSC2 -5.853 -4.6064 -5.853 58.7311
MS751 GDSC2 -5.6099 -2.4181 -5.6697 55.8894
SW954 GDSC2 -5.5788 -4.5125 -5.5789 55.9837
C-33 A GDSC2 -5.5269 -4.0283 -5.5273 55.4549
LB831-BLC GDSC2 -5.2728 -1.1157 -5.4926 52.5211
ACC-OV7 GDSC2 -5.2507 -2.2797 -5.3053 52.5588
CAL-39 GDSC2 -5.0477 -2.8453 -5.0607 50.6453
BPH-1 GDSC2 -4.7637 -1.212 -4.9251 47.9976
ME-180 GDSC2 -4.7206 -1.3863 -4.8502 47.5628
Ca Ski GDSC2 -4.5497 -0.1361 -4.9287 46.3317
JEG-3 GDSC2 -4.5106 -0.0306 -4.9142 46.0259
OVCA433 GDSC2 -4.4881 1.2714 -5.2959 46.3333
OMC-1 [Human cervical carcinoma] GDSC2 -4.4629 -0.4246 -4.7614 45.4426
OVMIU GDSC2 -4.2635 3.2785 -5.8283 45.5329
SKG-IIIa GDSC2 -4.1534 0.4972 -4.6776 43.1508
SiHa GDSC2 -4.085 -1.534 -4.1518 41.26
C-4-I GDSC2 -3.8783 -1.8155 -3.908 39.0546
HT-3 GDSC2 -3.8353 -0.5208 -4.0557 39.3761
JHOS-3 GDSC2 -3.7621 0.149 -4.1473 39.2506
HeLa GDSC2; CTRP2 -2.9758 3.5847 -3.2535 55.5168
TC-YIK GDSC2 -2.9043 1.9063 -3.8365 33.4601
OV17R GDSC2 -2.7266 3.3146 -4.2525 34.1512
SKN GDSC2 -2.6817 3.6766 -4.3693 34.3421
UWB1.289 GDSC2 -2.5045 1.45 -3.2311 28.8603
PEO1 GDSC2 -2.3057 3.2861 -3.8132 30.5768
SiSo GDSC2 -1.5327 6.4336 -4.569 30.324
HEC-1 GDSC2 -1.1766 5.2533 -3.6618 25.4258
HEY GDSC2 -1.0791 7.348 -4.608 28.8535
PWR-1E GDSC2 -1.0352 4.9544 -3.3853 23.6316
OVCA420 GDSC2 -0.8083 3.1851 -2.3078 17.0267
SW962 GDSC2 -0.4782 6.6387 -3.7258 23.3251
SW756 GDSC2 1.124 10.2067 -4.1996 20.7519
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7379).
2 Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
3 CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. Cell Rep. 2016 Nov 22;17(9):2367-2381. doi: 10.1016/j.celrep.2016.10.077.
4 Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol Cancer Ther. 2010 Aug;9(8):2344-53. doi: 10.1158/1535-7163.MCT-10-0324. Epub 2010 Jul 27.