General Information of Drug (ID: DMCU5LD)

Drug Name
Lonidamine
Synonyms
DICA; Doridamina; Lonidamin; Lonidamina; Lonidaminum; Dichlondazolic acid; Diclondazolic acid; AF 1890; L 4900; AF-1890; Doridamina (TN); KN-228; Lonidamina [INN-Spanish]; Lonidamine (INN); Lonidamine [BAN:INN]; Lonidaminum [INN-Latin]; TH-070; 1-(2,4-Dichlorbenzyl)-indazole-3-carboxylic acid; 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid; 1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid; 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid; 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 1-((2,4-dichlorophenyl)methyl)-(9CI)
Indication
Disease Entry ICD 11 Status REF
Benign prostatic hyperplasia GA90 Discontinued in Phase 3 [1]
Affected Organisms
Humans and other mammals
ATC Code
L01XX07: Lonidamine
L01XX: Other antineoplastic agents
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C15H10Cl2N2O2
Canonical SMILES
C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
InChI
1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
InChIKey
WDRYRZXSPDWGEB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
39562
ChEBI ID
CHEBI:50138
CAS Number
50264-69-2
UNII
U78804BIDR
DrugBank ID
DB06266
TTD ID
D09SIR

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 9.4752 12.6807 7.69 12.4912
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.9676 8.2557 4.7887 0.4073
GaMG CTRP1 7.4534 8.9867 4.7119 0.3922
LN-229 CTRP1 8.6359 14.5543 6.0452 27.5996
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 CTRP1 6.5603 8.5367 4.491 2.5826
HEC-265 CTRP1 6.6276 7.5774 4.9018 0.2279
HEC-108 CTRP1 6.9719 8.1741 4.8194 0.3058
HEC-251 CTRP1 7.4451 8.7514 4.7905 0.1954
HEC-6 CTRP1 7.5111 8.8592 4.777 0.2034
HEC-59 CTRP1 7.5855 8.7124 4.8515 0.0709
KLE CTRP1 7.9 9.7818 4.5975 0.5176
JHUEM-2 CTRP1 8.3642 11.7638 7.174 21.7622
HEC-151 CTRP1 9.3235 13.8275 6.9947 18.5981
Ishikawa (Heraklio) 02 ER- CTRP1 6.1249 8.1028 4.4359 3.9679
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BL-70 CTRP1 6.1368 7.4044 4.7544 1.5056
MC116 CTRP1 6.6087 7.5438 4.9066 0.2228
SKM-1 CTRP1 6.6702 9.7457 6.2752 38.4857
Ku812 CTRP1 7.1638 9.0053 4.5888 1.1093
KE-97 CTRP1 7.2444 8.7492 4.7174 0.4889
HT CTRP1 7.2839 8.4302 4.843 0.1385
WSU-DLCL2 CTRP1 7.8008 8.7182 7.7732 20.3239
P3HR-1 CTRP1 7.9359 9.4482 4.7259 0.1854
RPMI-8226 CTRP1 8.2535 9.7299 7.9891 15.7279
GDM-1 CTRP1 8.3447 13.6234 6.246 27.9479
NOMO-1 CTRP1 8.3925 9.1777 8.3263 12.1653
PL21 CTRP1 8.413 9.2302 8.3346 11.9674
OCI-AML-3 CTRP1 8.4521 9.1471 8.3991 11.2144
KMS-11 CTRP1 8.4854 12.5007 6.9273 22.9475
THP-1 CTRP1 8.4979 9.2654 8.417 10.7763
NU-DUL-1 CTRP1 8.5268 9.4101 8.4014 10.7176
LP-1 CTRP1 8.5333 9.211 8.4711 10.126
SU-DHL-5 CTRP1 8.5579 9.0535 8.5341 9.4822
MOLM-16 CTRP1 8.6473 9.345 8.5542 8.7443
SU-DHL-4 CTRP1 8.6836 9.2177 8.6333 7.8895
U-937 CTRP1 8.6996 9.2433 8.6434 7.7082
AMO1 CTRP1 8.9254 9.5798 8.7552 5.4445
EJM CTRP1 8.9594 9.8615 8.6571 6.1199
OCI-Ly10 CTRP1 9.6619 15.8583 6.2541 22.053
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.7703 9.4672 4.6602 0.3934
RCC10RGB CTRP1 9.1622 10.2791 8.6348 5.3783
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 CTRP1 6.1426 7.9863 4.5001 3.4074
GP2d CTRP1 6.5113 8.086 4.6567 1.5422
DLD-1 CTRP1 6.7178 7.674 4.9011 0.1912
LS411N CTRP1 7.3093 8.6057 4.7921 0.2367
LS513 CTRP1 7.3447 8.7527 4.754 0.3212
COLO205 CTRP1 7.4381 8.8884 4.7408 0.3167
SNU-C2A CTRP1 7.721 10.1647 4.3819 1.5765
C2BBe1 CTRP1 7.7219 9.3021 4.7001 0.3076
SK-CO-1 CTRP1 7.7808 9.5683 4.6285 0.4824
SW403 CTRP1 8.1026 9.5715 4.7417 0.1252
SNU-81 CTRP1 8.3551 9.3625 8.2312 13.1493
COLO 678 CTRP1 8.3697 9.8783 8.0519 14.5255
SW620 CTRP1 8.4003 10.6972 7.7171 17.183
SNU-175 CTRP1 8.5318 9.3371 8.4314 10.4469
SW480 CTRP1 8.534 14.5655 5.9496 28.5698
SNU-C4 CTRP1 8.5498 9.7936 8.2754 11.6188
CW-2 CTRP1 8.5636 9.606 8.3672 10.7732
HCT 116 CTRP1 8.5711 9.8095 8.2907 11.3684
HCT 8 CTRP1 8.6283 9.0833 8.6047 8.4758
LS180 CTRP1 8.6563 9.5794 8.476 9.3273
LoVo CTRP1 8.7244 9.6455 8.5199 8.5664
LS123 CTRP1 8.728 10.3833 8.1851 11.4379
HT-55 CTRP1 8.7492 9.5173 8.5992 7.7606
SNU-C5 CTRP1 8.7515 9.6751 8.5352 8.2837
COLO 320 CTRP1 8.8049 11.7759 7.5752 16.348
SNU-1040 CTRP1 8.834 9.5254 8.6849 6.5537
RCM-1 [Human ESC] CTRP1 8.8363 9.616 8.6483 6.8498
SNU-61 CTRP1 8.8487 9.8976 8.5326 7.7789
KM12 CTRP1 8.8518 9.8193 8.5721 7.4196
SW948 CTRP1 8.9158 9.6773 8.7013 5.9601
RKO CTRP1 8.9257 9.63 8.7328 5.6361
MDST8 CTRP1 8.9776 9.5698 8.8124 4.6708
NCI-H508 CTRP1 9.0083 9.6858 8.7882 4.7208
HT115 CTRP1 9.077 9.7887 8.8032 4.2497
HT-29 CTRP1 9.2282 10.3972 8.6311 5.1362
CL-34 CTRP1 9.3491 10.419 8.7168 3.8954
CL-40 CTRP1 9.4495 10.9656 8.5225 5.2659
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.396 7.1543 4.9647 0.1559
SNU-449 CTRP1 7.0309 9.7811 4.2037 3.7347
SNU-398 CTRP1 8.6699 9.3631 8.5725 8.4567
Hep-G2 CTRP1 11.1947 12.5633 8.765 0.3599
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L51 CTRP1 0.4452 115.65 -51.4801 52.507
NCI-H1930 CTRP1 5.1184 6.477 4.4983 6.7966
BEN CTRP1 6.1394 7.7526 4.6038 2.6034
NCI-H1573 CTRP1 6.6392 8.4912 4.5513 2.0269
NCI-H1435 CTRP1 6.6579 8.4079 4.5953 1.7105
NCI-H1944 CTRP1 6.6711 9.0406 4.3312 3.5278
EPLC-272H CTRP1 6.7761 8.7571 4.5085 2.0863
SHP-77 CTRP1 6.7827 11.0456 3.4753 9.8598
NCI-H1048 CTRP1 6.842 8.5413 4.6279 1.2631
NCI-H1568 CTRP1 6.8531 9.189 4.365 2.9289
RERF-LC-KJ CTRP1 6.8914 8.7437 4.5697 1.5352
NCI-H1793 CTRP1 7.0257 8.7056 4.6447 0.9709
A-549 CTRP1 7.0422 9.3606 4.389 2.441
NCI-H82 CTRP1 7.0456 8.5773 4.7017 0.6904
NCI-H661 CTRP1 7.0684 9.3392 4.4109 2.2584
NCI-H2009 CTRP1 7.073 9.3787 4.3968 2.3419
LCLC-103H CTRP1 7.136 8.3011 4.8349 0.1976
NCI-H2029 CTRP1 7.137 8.6707 4.7039 0.611
HCC33 CTRP1 7.1429 8.4184 4.7968 0.2915
COLO 668 CTRP1 7.1855 9.4154 4.4361 1.9314
COR-L279 CTRP1 7.1962 8.3748 4.8311 0.1864
DV-90 CTRP1 7.1991 8.9871 4.6109 0.9666
NCI-H2405 CTRP1 7.2218 9.3992 4.4596 1.744
Lu-65 CTRP1 7.2334 8.9283 4.6473 0.7715
Calu-6 CTRP1 7.2713 8.5451 4.7994 0.233
NCI-H2286 CTRP1 7.2785 8.7493 4.7304 0.425
COR-L88 CTRP1 7.3012 9.4119 4.4907 1.4718
NCI-H522 CTRP1 7.3527 8.9259 4.6954 0.5002
DMS 273 CTRP1 7.4025 8.9407 4.7091 0.4269
KNS-62 CTRP1 7.4244 9.0734 4.6699 0.5461
NCI-H1915 CTRP1 7.4358 8.9406 4.7216 0.3719
NCI-H810 CTRP1 7.4407 9.0982 4.6672 0.5457
HCC78 CTRP1 7.4468 9.0737 4.6784 0.5031
NCI-H2126 CTRP1 7.4569 8.5545 4.8604 0.0789
LCLC-97TM1 CTRP1 7.467 9.782 4.4191 1.6676
NCI-H1299 CTRP1 7.4738 9.0789 4.6868 0.46
VMRC-LCD CTRP1 7.4837 8.9492 4.7362 0.3098
NCI-H23 CTRP1 7.4928 9.3344 4.6014 0.7606
NCI-H650 CTRP1 7.5087 9.1511 4.6743 0.4816
NCI-H1355 CTRP1 7.5278 9.6165 4.51 1.1352
NCI-H1975 CTRP1 7.5372 9.087 4.7077 0.3648
NCI-H727 CTRP1 7.5494 9.4005 4.5997 0.7259
LC-1/sq-SF CTRP1 7.6007 8.7098 4.8574 0.0629
HCC44 CTRP1 7.6269 9.8061 4.4796 1.1858
NCI-H1792 CTRP1 7.64 9.1868 4.7105 0.3134
Lu-99 CTRP1 7.6532 9.0889 4.7488 0.2191
NCI-H1963 CTRP1 7.7111 16.5581 4.2222 38.4968
ChaGo-K-1 CTRP1 7.7215 9.6092 4.5912 0.6421
NCI-H358 CTRP1 7.7569 9.8518 4.5162 0.9097
Calu-3 CTRP1 7.7692 9.3151 4.7126 0.2609
EBC-1 CTRP1 7.7923 9.3128 4.7215 0.2338
NCI-H1437 CTRP1 7.9042 9.6279 4.6531 0.3554
HARA [Human squamous cell lung carcinoma] CTRP1 7.9473 9.4938 4.7144 0.2035
NCI-H2342 CTRP1 7.9838 10.5284 7.3734 22.3248
NCI-H2141 CTRP1 8.1458 9.6762 7.8946 17.1487
NCI-H1666 CTRP1 8.196 9.8627 4.6763 0.2093
NCI-H2081 CTRP1 8.2317 9.7791 7.9467 16.2059
NCI-H1876 CTRP1 8.3057 13.907 6.0707 29.0792
NCI-H1105 CTRP1 8.3246 20.8042 2.6591 39.0163
NCI-H1373 CTRP1 8.3434 10.1233 4.6395 0.2392
LXF 289 CTRP1 8.3616 10.2757 4.594 0.3294
NCI-H1694 CTRP1 8.3672 9.5406 8.1826 13.4643
NCI-H1836 CTRP1 8.3726 9.4172 8.232 13.0332
SK-LU-1 CTRP1 8.4086 12.8231 6.6984 24.8984
NCI-H841 CTRP1 8.4266 9.6837 8.1912 13.0363
NCI-H2122 CTRP1 8.4272 9.6865 8.1907 13.0372
NCI-H2023 CTRP1 8.5113 13.4341 6.4904 25.6933
HCC4006 CTRP1 8.5242 9.877 8.2132 12.2879
NCI-H596 CTRP1 8.5347 9.3726 8.4228 10.4971
NCI-H441 CTRP1 8.5492 9.7679 8.2857 11.5362
SCLC-21H CTRP1 8.5911 9.2191 8.532 9.2779
HCC2108 CTRP1 8.5995 9.9198 8.2719 11.3681
NCI-H1755 CTRP1 8.6215 9.5945 8.4332 9.8864
T3M-10 CTRP1 8.637 9.8485 8.3418 10.5659
HCC15 CTRP1 8.6421 9.3351 8.5519 8.7955
NCI-H2172 CTRP1 8.7175 13.4851 6.6489 23.6921
NCI-H460 CTRP1 8.7766 9.133 8.7555 6.3394
NCI-H1781 CTRP1 8.7845 9.3114 8.7144 6.6082
NCI-H2073 CTRP1 8.7872 9.5034 8.6448 7.1592
NCI-H2030 CTRP1 8.7993 9.7305 8.5598 7.8082
HCC1833 CTRP1 8.8094 9.5868 8.6332 7.1291
HCC1359 CTRP1 8.8774 9.3543 8.7993 5.351
CAL-12T CTRP1 8.892 10.2917 8.3854 8.8549
HCC827 CTRP1 8.9591 9.7933 8.6895 5.8366
Sq-1 CTRP1 8.962 9.698 8.7374 5.4033
HCC1195 CTRP1 9.024 14.755 6.2807 24.5384
COR-L23 CTRP1 9.0774 9.7507 8.8223 4.0777
HCC2935 CTRP1 9.0831 10.5355 8.4384 7.4903
COLO 699 CTRP1 9.0926 9.9554 8.7351 4.7848
NCI-H2110 CTRP1 9.6536 13.0267 7.6571 12.0868
NCI-H3255 CTRP1 9.6856 11.2249 8.5656 4.1028
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 7.5973 8.8467 4.811 0.121
KYSE-410 CTRP1 7.8206 9.5951 4.6339 0.4461
KYSE-140 CTRP1 8.1557 10.1082 4.5775 0.4526
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COV318 CTRP1 7.0096 7.8008 4.9586 0.0346
OVMANA CTRP1 7.0188 8.5619 4.6964 0.7354
HEY A8 CTRP1 7.1606 8.3689 4.8204 0.223
SK-OV-3 CTRP1 7.274 8.7797 4.7178 0.4696
EFO-21 CTRP1 7.4185 8.7552 4.7798 0.2272
JHOS-4 CTRP1 7.8434 9.5318 4.6644 0.3507
RMUG-S CTRP1 8.0987 11.4214 7.0814 23.8985
OV-90 CTRP1 8.4185 11.1479 7.5219 18.7156
JHOM-1 CTRP1 8.4629 9.803 8.1809 12.91
COV434 CTRP1 8.4955 11.4005 7.474 18.7094
OVKATE CTRP1 8.5252 9.9468 8.1839 12.5304
SNU-840 CTRP1 8.545 12.9864 6.7422 23.9199
TYK-nu CTRP1 8.5625 9.3412 8.4635 9.999
OVK18 CTRP1 8.578 12.2455 7.1377 20.9427
RMG-I CTRP1 8.6289 10.874 7.8548 14.8187
A2780 CTRP1 8.678 12.1364 7.2825 19.3344
Caov-3 CTRP1 8.723 9.1726 8.6881 7.2094
IGROV-1 CTRP1 8.794 10.1988 8.3368 9.772
OAW42 CTRP1 8.9166 9.5072 8.7783 5.2971
COV644 CTRP1 9.0463 9.8538 8.7429 4.9332
EFO-27 CTRP1 9.1533 10.0549 8.739 4.4786
OVCAR-4 CTRP1 9.2934 14.405 6.6813 20.8968
OV7 CTRP1 9.6263 13.0216 7.6387 12.3431
OVCAR-8 CTRP1 10.2417 16.2815 6.4925 18.4756
JHOC-5 CTRP1 10.2948 16.063 6.6398 17.353
COV362 CTRP1 10.4511 15.805 6.8805 15.214
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC CTRP1 6.7857 11.3052 3.354 10.7634
HuP-T4 CTRP1 7.0108 9.1832 4.4473 2.1149
CFPAC-1 CTRP1 7.1335 9.3049 4.4563 1.8817
PaTu 8902 CTRP1 7.162 8.5907 4.7428 0.4501
KP-3 CTRP1 7.3035 11.8992 3.4069 8.9666
QGP-1 CTRP1 7.3039 8.9503 4.6675 0.6349
Capan-2 CTRP1 7.3413 9.883 4.3195 2.423
SUIT-2 CTRP1 7.4184 8.8144 4.7593 0.2763
Panc 03.27 CTRP1 7.6253 9.0883 4.7391 0.2493
Panc 10.05 CTRP1 7.6905 9.1885 4.728 0.2526
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP1 7.0806 9.2221 4.4649 1.9036
MSTO-211H CTRP1 7.3532 9.3398 4.5415 1.1524
NCI-H2052 CTRP1 7.6621 9.6098 4.5676 0.7717
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 7.2155 8.2437 4.8819 0.0913
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 936.T CTRP1 6.35 7.7629 4.7114 1.4399
G-361 CTRP1 6.8955 9.8529 4.0968 4.8021
Hs 852.T CTRP1 6.9868 8.7118 4.6255 1.1088
COLO 741 CTRP1 7.7298 9.7552 4.541 0.8283
Hs 944.T CTRP1 7.8554 9.2427 4.7671 0.1354
SK-MEL-5 CTRP1 8.6286 9.2044 8.5769 8.6848
A-375 CTRP1 8.8266 9.4905 8.6916 6.5405
SK-MEL-1 CTRP1 9.3281 10.4904 8.665 4.4381
SK-MEL-28 CTRP1 10.0208 10.9753 8.876 0.8914
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 6.7357 9.6651 4.0885 5.231
HT-1080 CTRP1 8.5391 9.5354 8.3687 10.9072
RKN CTRP1 8.6872 9.1206 8.661 7.6541
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-10-TC CTRP1 6.9981 8.1219 4.8473 0.218
NUGC-4 CTRP1 7.143 8.7724 4.6686 0.7535
Fu97 CTRP1 7.4525 9.4787 4.5306 1.1083
MKN7 CTRP1 7.7328 9.5371 4.6215 0.5307
MKN74 CTRP1 7.8857 10.0435 4.4971 0.8899
AGS CTRP1 8.7683 9.6195 8.5766 7.8391
SNG-M CTRP1 7.4064 8.8964 4.7263 0.3722
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 7.1917 8.3173 4.8491 0.1511
SCC-9 CTRP1 9.2592 10.2449 8.7326 4.0968
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 CTRP1 6.8844 8.9663 4.4751 2.1318
RT-4 CTRP1 6.9719 9.6045 4.2487 3.5276
UM-UC-3 CTRP1 7.2295 9.1624 4.5565 1.2046
KMBC-2 CTRP1 7.8299 9.5972 4.6366 0.4337
5637 CTRP1 8.0349 9.8222 4.6331 0.3549

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022059)