Details of the Drug

General Information of Drug (ID: DMCWIBU)

Drug Name
BMS-3870032
Synonyms
SNS-032; BMS-387032; SNS 032; BMS 387032; N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide; SNS-032 (BMS-387032); N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)piperidine-4-carboxamide; N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide; UNII-9979I93686; N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide; CHEMBL296468; SNS032; C17H24N4O2S2; BMS387032
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 380.5
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 6
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 7
Chemical Identifiers
Formula
C17H24N4O2S2
IUPAC Name
N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
Canonical SMILES
CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
InChI
InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
InChIKey
OUSFTKFNBAZUKL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3025986
ChEBI ID
CHEBI:91399
CAS Number
345627-80-7
UNII
9979I93686
DrugBank ID
DB05969
VARIDT ID
DR01721

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 7 (CDK7) OTAO19PQ CDK7_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 9 (CDK9) OT2B7OGB CDK9_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 127 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -4.1385 -1.0868 -4.1403 67.5639
MEC1 CTRP2 -2.0581 -0.789 -2.0581 53.9797
OCI-AML-3 CTRP2 -6.4154 -5.9482 -6.4154 83.0091
Hs 611.T CTRP2 -5.0067 -1.2614 -5.0119 72.5795
ST486 CTRP2 -4.0688 -1.4696 -4.0693 67.2527
GA-10 CTRP2 -3.9099 -0.4903 -3.9151 65.9395
EoL-1 CTRP2 -3.8703 -0.9426 -3.8718 65.8663
MOLP-8 CTRP2 -3.7295 -1.3478 -3.7297 65.0585
KMS-11 CTRP2 -3.5999 -0.5724 -3.6024 64.0748
PL21 CTRP2 -3.5459 -2.5545 -3.5459 63.892
WSU-DLCL2 CTRP2 -3.5356 -2.2585 -3.5356 63.8232
SU-DHL-8 CTRP2 -3.4513 -0.632 -3.4528 63.1511
NALM-6 CTRP2 -3.3973 -2.038 -3.3973 62.9015
Ki-JK CTRP2 -3.3928 -2.5276 -3.3928 60.2217
RS4;11 CTRP2 -3.3899 -1.9983 -3.3899 62.8521
EM-2 CTRP2 -3.3811 -2.3566 -3.3811 60.138
SU-DHL-4 CTRP2 -3.3659 -1.1382 -3.366 62.6662
DEL CTRP2 -3.36 -2.9733 -3.36 59.9878
KE-97 CTRP2 -3.3586 -2.2399 -3.3586 62.644
OCI-AML-2 CTRP2 -3.3582 -2.1657 -3.3582 62.6411
L-363 CTRP2 -3.3516 -1.3518 -3.3516 62.5849
MOLM-13 CTRP2 -3.3314 -1.9858 -3.3314 59.7832
P31/FUJ CTRP2 -3.3276 -2.9475 -3.3276 59.7566
U-937 CTRP2 -3.3196 -2.5994 -3.3196 62.3844
OCI-AML-5 CTRP2 -3.2549 -2.8258 -3.2549 61.9531
SR CTRP2 -3.2394 -1.0562 -3.2396 61.8299
THP-1 CTRP2 -3.2204 -0.843 -3.2208 61.689
SKM-1 CTRP2 -3.2177 -1.5486 -3.2177 61.7029
BV-173 CTRP2 -3.2115 -1.117 -3.2116 61.6495
KMS-21-BM CTRP2 -3.1685 -1.4628 -3.1686 58.6182
SU-DHL-6 CTRP2 -3.1486 -0.5049 -3.1498 61.1857
SUP-HD1 CTRP2 -3.1411 1.0644 -3.1723 60.7056
JJN-3 CTRP2 -3.1258 -1.809 -3.1258 61.0927
Kasumi-2 CTRP2 -3.1255 -2.1818 -3.1255 61.0911
Karpas-299 CTRP2 -3.1155 -1.5199 -3.1155 61.0231
SU-DHL-10 CTRP2 -3.1133 -1.2867 -3.1133 61.0049
AML-193 CTRP2 -3.036 -2.3404 -3.036 60.495
DND-41 CTRP2 -3.0058 -1.2861 -3.0059 60.2914
OCI-Ly19 CTRP2 -2.7967 1.4601 -2.8367 58.5108
SIG-M5 CTRP2 -2.791 -1.2747 -2.791 58.8622
SEM CTRP2 -2.7526 -1.8666 -2.7526 58.607
NCI-H929 CTRP2 -2.7026 -1.0226 -2.7026 58.2724
RCH-ACV CTRP2 -2.6774 0.2486 -2.6812 58.04
MOLP-2 CTRP2 -2.6385 -0.1358 -2.6396 57.8209
SUP-B15 CTRP2 -2.5556 -1.0826 -2.5556 57.2943
Karpas-422 CTRP2 -2.5488 -1.9426 -2.5488 57.2491
Daudi CTRP2 -2.5345 -1.7729 -2.5345 57.1536
LP-1 CTRP2 -2.5274 -1.7737 -2.5274 57.1063
HL-60 CTRP2 -2.4343 -1.9173 -2.4343 56.4862
MOTN-1 CTRP2 -2.374 -1.7224 -2.374 56.0844
KCL-22 CTRP2 -2.3449 -0.1743 -2.3453 55.8838
Peer CTRP2 -2.3152 -0.6943 -2.3153 52.5302
U266B1 CTRP2 -2.3015 -0.8118 -2.3015 55.6011
M-07e CTRP2 -2.2379 -0.7638 -2.2379 55.1775
MHH-CALL-4 CTRP2 -2.205 1.6377 -2.236 54.8206
MV4-11 CTRP2 -2.1664 -0.8201 -2.1664 54.7015
HDLM-2 CTRP2 -2.0891 -0.5888 -2.0891 54.1865
MOLT-16 CTRP2 -2.0705 -0.4909 -2.0705 54.0621
Jurkat CTRP2 -2.032 -0.4809 -2.032 53.806
MM1.S CTRP2 -1.9378 -0.4235 -1.9378 53.1782
SUP-T1 CTRP2 -1.9331 0.0952 -1.9334 53.1451
KMS-27 CTRP2 -1.9273 -0.9911 -1.9273 53.1086
KE-37 CTRP2 -1.9179 -0.6853 -1.9179 49.6946
MOLT-13 CTRP2 -1.9078 0.5034 -1.9093 52.9718
CML-T1 CTRP2 -1.9059 -0.2662 -1.9061 49.6092
MC116 CTRP2 -1.8608 -0.386 -1.8608 52.6655
HT CTRP2 -1.8302 -0.5827 -1.8302 49.0687
NCO2 CTRP2 -1.774 0.27 -1.7752 48.6688
RPMI-8402 CTRP2 -1.7692 -0.6443 -1.7692 48.6331
SU-DHL-1 CTRP2 -1.7624 -1.0259 -1.7624 48.5843
MOLM-16 CTRP2 -1.7605 0.8325 -1.7637 51.9903
NOMO-1 CTRP2 -1.7543 0.6442 -1.756 51.9516
NB4 CTRP2 -1.7469 -1.0914 -1.7469 51.907
K-562 CTRP2 -1.7212 1.9289 -1.752 51.6982
KMS-28BM CTRP2 -1.7187 1.459 -1.7321 51.6997
RPMI-8226 CTRP2 -1.6885 -0.124 -1.6886 51.5178
KMS-12-BM CTRP2 -1.6767 -0.4481 -1.6767 51.4393
PF-382 CTRP2 -1.6297 -0.2981 -1.6297 51.1259
F-36P CTRP2 -1.5727 0.6331 -1.5737 50.7454
KO52 CTRP2 -1.509 0.2453 -1.5091 50.3215
P12-Ichikawa CTRP2 -1.5078 -0.72 -1.5078 46.7671
ALL-SIL CTRP2 -1.4836 -0.1657 -1.4836 50.1525
KMS-20 CTRP2 -1.4441 0.4427 -1.4443 49.8892
Ri-1 CTRP2 -1.3439 3.2401 -1.4615 49.2637
NU-DHL-1 CTRP2 -1.3318 1.4848 -1.3399 49.1459
KMS-26 CTRP2 -1.323 0.3566 -1.3231 49.0831
Granta-519 CTRP2 -1.2977 9.0201 -2.9404 49.2796
SUP-T11 CTRP2 -1.2861 -0.4022 -1.2861 48.8368
EHEB CTRP2 -1.2382 0.5414 -1.2404 40.8076
JVM-2 CTRP2 -1.2225 3.0558 -1.3136 48.4792
Kasumi-1 CTRP2 -1.1966 2.049 -1.2184 48.2622
KMS-34 CTRP2 -1.1557 -0.2844 -1.1557 47.9678
JURL-MK1 CTRP2 -1.0719 0.4937 -1.0722 43.6573
Mono-Mac-1 CTRP2 -1.0659 4.0567 -1.2769 47.5729
Ku812 CTRP2 -0.9986 1.0618 -0.9997 46.9238
NU-DUL-1 CTRP2 -0.9719 0.8741 -0.9723 46.7446
HPB-ALL CTRP2 -0.8704 0.1408 -0.8704 46.0676
KMS-18 CTRP2 -0.771 0.1401 -0.771 45.4051
HuT 78 CTRP2 -0.6202 12.1082 -3.4611 46.811
MOLM-6 CTRP2 -0.5836 1.1116 -0.5839 44.1577
GDM-1 CTRP2 -0.4621 1.9252 -0.4675 43.3624
AMO1 CTRP2 -0.4131 1.1317 -0.4133 43.0215
L-540 CTRP2 -0.3802 0.4374 -0.3802 42.8016
KM-H2 CTRP2 -0.3402 1.0709 -0.3403 42.5355
KYO-1 CTRP2 -0.0691 2.1073 -0.0732 40.7419
LAMA-84 CTRP2 0.1336 2.8687 0.1122 39.4448
TF-1 CTRP2 0.7465 2.76 0.7409 35.3138
HD-MY-Z CTRP2 0.964 6.826 0.2685 35.8889
RL CTRP2 0.9858 5.9156 0.5584 35.0163
L-428 CTRP2 1.2264 2.8161 1.2246 32.1041
CMK CTRP2 1.2454 3.3273 1.2335 32.0114
MHH-CALL-3 CTRP2 1.4963 11.2012 -0.8842 36.6526
SET-2 CTRP2 1.5446 2.1942 1.5446 29.9782
ME1 CTRP2 1.6279 3.1232 1.6259 29.4301
HEL 92.1.7 CTRP2 1.7287 2.3226 1.7287 28.7518
L-1236 CTRP2 1.8534 7.5347 0.9918 30.7685
HEL CTRP2 2.0088 3.4137 2.0064 26.8937
SK-MM-2 CTRP2 2.2735 4.2302 2.2481 25.2074
Mono-Mac-6 CTRP2 2.7876 17.1354 -2.4041 35.6863
TALL-1 [Human adult T-ALL] CTRP2 3.2317 10.8311 1.0358 26.5275
P3HR-1 CTRP2 3.5977 13.0849 0.3231 27.7024
OCI-M1 CTRP2 4.7766 8.5653 3.6173 12.941
KMM-1 CTRP2 6.4612 12.1402 2.5967 8.3681
REC-1 CTRP2 7.4081 10.9833 4.5979 3.8962
Karpas-620 CTRP2 7.8342 9.1497 5.6145 0.1958
Raji CTRP2 7.9171 9.3228 5.5841 0.2223
Reh CTRP2 8.3129 9.5862 5.637 0.0762
⏷ Show the Full List of 127 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 -1.4897 -0.3425 -1.4897 50.1929
TE15 CTRP2 -1.1025 3.3232 -1.2152 47.7265
OE21 CTRP2 -2.3511 -0.8926 -2.3511 55.9321
TE-11 CTRP2 -2.2893 -1.3595 -2.2893 55.5205
KYSE-180 CTRP2 -1.8003 -0.6029 -1.8003 52.2628
TE-5 CTRP2 -1.741 4.8135 -2.1503 51.5877
EC-GI-10 CTRP2 -1.2048 0.3959 -1.2049 48.2956
TE-4 CTRP2 -1.0041 0.0883 -1.0041 46.958
KYSE-140 CTRP2 -0.6595 4.1676 -0.8581 45.0089
TE-9 CTRP2 -0.6183 0.3647 -0.6183 44.3878
TE-10 CTRP2 -0.551 2.8787 -0.596 44.0431
TE-14 CTRP2 -0.461 2.4714 -0.4812 43.3921
KYSE-70 CTRP2 -0.4212 0.3408 -0.4212 43.0745
KYSE-510 CTRP2 0.3711 2.6613 0.3622 37.8251
KYSE-410 CTRP2 2.5383 9.4852 0.9363 28.8169
KYSE-520 CTRP2 3.1799 11.6236 0.6153 27.9628
KYSE-450 CTRP2 3.6892 9.5656 2.0744 21.7134
COLO 680N CTRP2 3.7784 10.3833 1.7846 22.5331
TE-1 CTRP2 4.1405 9.5666 2.5229 18.858
KYSE-150 CTRP2 4.2244 13.3624 0.7765 24.7872
KYSE-30 CTRP2 4.936 12.1966 2.0019 18.9342
OE19 CTRP2 7.2462 18.5697 0.753 18.5811
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.0946 10.7631 1.9131 21.2638
Panc 08.13 CTRP2 -2.0464 1.5844 -2.0709 53.8178
SU.86.86 CTRP2 -1.8569 1.6259 -1.8785 52.5934
DAN-G CTRP2 -1.671 0.1602 -1.6712 51.4009
BxPC-3 CTRP2 -1.522 0.3928 -1.5229 46.8708
HuP-T4 CTRP2 -1.1817 0.0988 -1.1818 48.1416
SNU-213 CTRP2 -0.6715 1.6056 -0.6923 36.5358
L3.3 CTRP2 -0.2626 0.9997 -0.2626 42.0179
Hs 766T CTRP2 -0.2371 6.8893 -1.0588 43.3409
Panc 03.27 CTRP2 -0.0085 6.1699 -0.596 41.6253
KP-2 CTRP2 0.1103 4.9295 -0.1649 40.2478
KP-4 CTRP2 0.152 1.3383 0.1518 34.9209
KP-3 CTRP2 0.3146 4.9136 0.0598 38.8826
HPAC CTRP2 1.0149 5.9206 0.5889 34.8244
YAPC CTRP2 1.9089 6.6431 1.3546 29.4241
HuP-T3 CTRP2 2.0739 9.6017 0.405 31.7894
Panc 10.05 CTRP2 2.7379 16.9167 -2.3445 35.7151
PK-59 CTRP2 3.1592 8.3172 2.0777 23.1462
Panc 04.03 CTRP2 3.3664 11.1892 1.0022 26.2694
SNU-410 CTRP2 3.4701 14.1234 -0.2997 29.6958
PK-45H CTRP2 3.8348 14.7168 -0.2475 28.6459
SW1990 CTRP2 3.916 13.2854 0.5266 26.3043
Capan-2 CTRP2 4.426 13.4492 0.9197 23.8531
QGP-1 CTRP2 4.7761 10.2442 2.2176 13.225
TCC-Pan2 CTRP2 5.0684 11.4128 2.509 16.7099
Panc 05.04 CTRP2 5.0756 16.1892 0.1436 24.7026
PSN1 CTRP2 5.1702 13.6595 1.4859 20.2632
AsPC-1 CTRP2 5.3176 17.0988 -0.0996 24.857
CFPAC-1 CTRP2 5.7562 11.1265 2.5742 9.6942
PaTu 8988s CTRP2 6.3547 38.7726 -10.0618 37.3128
SUIT-2 CTRP2 7.1565 11.676 4.093 6.2833
PaTu 8988t CTRP2 8.2334 19.7602 0.9143 16.3961
Panc 02.03 CTRP2 8.4063 18.8245 1.4999 14.198
PaTu 8902 CTRP2 8.8035 20.4652 0.984 15.278
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -3.9017 6.4287 -4.9174 60.6476
RPMI-7951 CTRP2 -3.5232 -2.5702 -3.5232 63.7405
WM88 CTRP2 -2.1759 -1.2277 -2.1759 54.7645
Hs 294T CTRP2 -2.058 -0.8939 -2.058 53.9795
WM266-4 CTRP2 -2.0202 -0.8068 -2.0202 53.7274
A101D CTRP2 -1.7441 0.0385 -1.7442 51.8878
WM115 CTRP2 -1.6799 1.3618 -1.6903 51.4472
IGR-37 CTRP2 -1.2861 -0.1231 -1.2861 48.8367
RVH-421 CTRP2 -1.0834 0.8541 -1.0839 47.4871
CJM [Human melanoma] CTRP2 -1.0312 3.1331 -1.1197 47.2464
Mel Ho CTRP2 -0.8194 1.6056 -0.8238 45.7378
K029AX CTRP2 -0.7671 1.2659 -0.7682 45.382
MeWo CTRP2 -0.7571 3.4214 -0.8606 45.4938
Mel JuSo CTRP2 -0.7416 0.167 -0.7416 45.209
Hs 852.T CTRP2 -0.7018 7.7702 -1.8523 46.213
COLO 829 CTRP2 -0.5846 2.1381 -0.5963 44.1931
Hs 936.T CTRP2 -0.5637 2.2348 -0.5779 44.0599
Hs 944.T CTRP2 -0.4984 1.2063 -0.4988 43.5903
MDA-MB-435S CTRP2 -0.4757 3.1681 -0.5395 43.5866
COLO 741 CTRP2 -0.4608 10.9409 -3.1907 43.731
A-375 CTRP2 -0.3288 0.4003 -0.3288 42.4591
G-361 CTRP2 -0.2956 0.4518 -0.2956 42.2382
SK-MEL-30 CTRP2 -0.116 1.4898 -0.1163 41.0425
LOX-IMVI CTRP2 -0.1043 5.7095 -0.5775 42.0016
UACC-257 CTRP2 -0.0751 2.5686 -0.0899 40.8132
HMCB CTRP2 0.2071 3.2049 0.1698 39.003
HT-144 CTRP2 0.2105 3.5198 0.1491 39.0503
COLO 800 CTRP2 0.4258 9.5319 -1.2972 41.039
SK-MEL-2 CTRP2 0.4922 2.7642 0.4826 37.0211
COLO 792 CTRP2 0.6029 2.8039 0.5942 36.2805
SK-MEL-3 CTRP2 0.679 2.4116 0.6772 35.751
WM793 CTRP2 0.8857 3.8296 0.8299 34.5501
UACC-62 CTRP2 0.8978 2.5553 0.8961 34.293
Hs 839.T CTRP2 1.0037 6.244 0.4876 35.1525
WM1799 CTRP2 1.168 5.3569 0.8933 33.3729
SK-MEL-5 CTRP2 1.5572 2.0871 1.5572 29.8943
SK-MEL-28 CTRP2 1.5641 3.0463 1.5623 29.8544
IPC-298 CTRP2 1.9227 5.3512 1.7148 28.1652
Hs 940.T CTRP2 1.9408 10.5195 -0.129 33.5914
SK-MEL-1 CTRP2 2.1861 4.6177 2.1203 25.9266
Hs 895.T CTRP2 3.0439 8.7874 1.7594 24.6139
SK-MEL-31 CTRP2 3.0836 7.8202 2.2003 22.9135
WM983B CTRP2 4.2972 28.5915 -6.7163 37.7063
Hs 934.T CTRP2 6.1385 16.8959 0.6969 20.8381
IGR-39 CTRP2 7.5889 22.4266 -0.8979 22.6143
Hs 688(A).T CTRP2 9.2534 20.9885 1.0483 14.4007
WT2-iPS CTRP2 9.8454 19.0381 2.3762 9.1314
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 1.4893 10.1419 -0.4324 35.7387
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-SI9s CTRP2 -1.2166 0.4062 -1.2167 48.3738
NB1 CTRP2 -1.1729 -0.5305 -1.1729 48.0825
CHP-126 CTRP2 -0.7188 2.069 -0.731 45.0854
MHH-NB-11 CTRP2 -0.698 2.0482 -0.723 41.0648
Kelly CTRP2 0.1271 2.5105 0.1178 39.4512
SK-N-DZ CTRP2 0.1272 4.4577 -0.0595 39.9282
SK-N-BE(2) CTRP2 1.0489 6.3107 0.5176 34.9067
NH-6 CTRP2 1.2744 9.4824 -0.3815 36.3454
SK-N-SH CTRP2 1.4912 6.9121 0.814 32.5088
KP-N-YN CTRP2 7.1463 17.5087 1.2027 17.3067
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 -1.041 27.1115 -10.8514 49.2037
SNU-1079 CTRP2 -0.3677 8.0136 -1.5752 44.5208
SNU-308 CTRP2 -0.2599 1.0811 -0.26 42.0005
SNU-478 CTRP2 -0.239 3.5943 -0.3317 42.096
HuH-28 CTRP2 0.8129 4.2675 0.7039 35.2014
HuCC-T1 CTRP2 1.08 7.5732 0.1437 35.7916
SNU-1196 CTRP2 5.06 14.5909 0.9254 22.3785
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 -4.5968 -0.7278 -4.6051 69.9786
SK-N-MC CTRP2 -2.3074 -1.7589 -2.3074 55.6409
SK-ES-1 CTRP2 -2.2489 -1.0707 -2.2489 55.2514
MHH-ES-1 CTRP2 -1.8873 0.2093 -1.8878 52.8398
SW1353 CTRP2 -0.6069 0.2136 -0.6069 40.3372
CAL-78 CTRP2 -0.5407 1.658 -0.5435 43.8787
SaOS-2 CTRP2 0.378 6.9915 -0.4219 39.7114
SJSA-1 CTRP2 1.8415 7.9847 0.8126 31.3549
CADO-ES1 CTRP2 1.858 4.0051 1.8314 27.9795
G-292 clone A141B1 CTRP2 3.0577 9.9594 1.2592 26.2846
HOS CTRP2 5.2879 15.2484 0.7977 22.2843
Hs 822.T CTRP2 6.7322 10.4638 4.3784 5.7808
MG-63 CTRP2 7.9272 20.4712 0.3337 18.683
Hs 888.T CTRP2 8.1801 19.1324 1.1837 15.6121
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 65 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 -2.7255 2.8418 -2.8797 57.5677
MDA-MB-468 CTRP2 -2.3232 -1.0882 -2.3232 55.7462
MCF-7 CTRP2 -1.9262 3.9253 -2.4319 46.6974
SK-BR-3 CTRP2 -1.7968 -0.4311 -1.7968 52.239
EFM-192A CTRP2 -1.6745 1.5944 -1.691 51.406
HCC1143 CTRP2 -1.6069 0.6198 -1.608 50.973
HMC-1-8 CTRP2 -1.2622 -0.4227 -1.2622 48.6773
HCC38 CTRP2 -1.2369 5.986 -1.886 48.7851
CAL-51 CTRP2 -1.1914 1.6428 -1.2008 48.2163
BT-20 CTRP2 -0.8715 1.4597 -0.8747 46.082
HCC2218 CTRP2 0.0088 7.7152 -1.064 42.3139
ZR-75-1 CTRP2 0.146 5.3021 -0.2062 40.1946
BT-549 CTRP2 0.1638 7.7789 -0.9185 41.4624
HCC1419 CTRP2 0.4804 11.0848 -1.882 41.6428
CAL-85-1 CTRP2 0.7737 11.3728 -1.702 40.4006
CAL-148 CTRP2 1.1798 9.5387 -0.5041 36.9313
HCC1395 CTRP2 1.1969 7.5908 0.2638 35.07
CAMA-1 CTRP2 1.2446 7.6821 -0.4082 28.3135
MDA-MB-231 CTRP2 1.5038 6.8071 0.8616 32.3226
HCC202 CTRP2 1.8973 11.7016 -0.6996 35.0228
HCC1500 CTRP2 2.0299 8.7565 0.7102 31.0571
ZR-75-30 CTRP2 2.1002 10.8804 -0.1255 33.0908
HDQ-P1 CTRP2 3.4591 12.3531 0.5416 27.4321
MDA-MB-453 CTRP2 4.7954 13.0574 1.4494 21.2318
HCC1937 CTRP2 5.8635 14.8184 1.5057 18.7251
MDA-MB-361 CTRP2 6.5776 20.1159 -0.5521 23.5467
KPL-1 CTRP2 7.0584 7.9501 5.7468 0.2135
CAL-120 CTRP2 7.5829 14.479 3.0304 9.8832
JIMT-1 CTRP2 8.2197 16.5728 2.4644 11.0581
T-47D CTRP2 8.6117 18.6572 1.7284 13.1006
BT-474 CTRP2 8.6283 19.8463 1.1604 14.9798
BT 145 CTRP2 -2.2104 -1.6104 -2.2104 54.9948
BT164 CTRP2 -2.1403 -1.4575 -2.1403 54.5275
BT 482 CTRP2 -1.1677 0.8907 -1.1686 48.0495
BT 428 CTRP2 -1.0065 1.5243 -1.0116 46.9834
BT 228 CTRP2 -0.6112 0.0403 -0.6112 44.3403
BT 231 CTRP2 -0.5917 1.0549 -0.5919 44.2111
BT 245 CTRP2 -0.4841 4.4582 -0.7184 43.9535
BT 239 CTRP2 -0.231 4.4011 -0.4356 42.2847
BT 131 CTRP2 -0.0413 6.0884 -0.6092 41.7885
BT 159 CTRP2 0.1051 0.8604 0.1051 39.5686
BT 440 CTRP2 0.129 2.7883 0.1109 39.4652
BT 416 CTRP2 0.3243 1.411 0.3243 38.108
BT 422 CTRP2 0.5964 4.5897 0.4235 36.8221
BT 498 CTRP2 1.0828 10.2481 -0.9005 38.0469
BT 139 CTRP2 1.4217 4.7108 1.2911 31.2321
BT 179 CTRP2 1.5579 2.7877 1.5575 29.8909
BT 359 CTRP2 1.9708 7.9302 0.9716 30.4546
BT 286 CTRP2 2.7741 10.3344 0.8034 28.5353
BT 333 CTRP2 2.9308 9.0706 1.5208 25.7645
BT 328 CTRP2 2.9693 9.0779 1.5574 25.5292
BT 112 CTRP2 3.5066 12.3769 0.576 27.2058
BT 504 CTRP2 3.5663 11.1386 1.2218 25.0252
BT 224 CTRP2 3.9364 8.4906 2.8083 18.2792
BT 271 CTRP2 4.1025 12.6151 1.0275 24.2917
BT 248 CTRP2 4.2233 10.7008 2.0667 20.3791
BT 330 CTRP2 4.3573 13.436 0.8631 24.1962
BT 187 CTRP2 4.4799 10.5193 2.3991 18.499
BT147 CTRP2 4.7257 19.6728 -1.8977 30.3347
BT 172 CTRP2 5.6918 16.2678 0.636 21.9325
BT 216 CTRP2 6.4516 14.387 2.2074 15.0248
BT 320 CTRP2 6.8976 10.369 4.5453 4.8325
BT 340 CTRP2 7.6128 8.7501 5.6733 0.1627
BT 444 CTRP2 7.8094 17.4407 1.7419 14.3213
BT 232 CTRP2 9.0245 22.5498 0.1243 17.5398
⏷ Show the Full List of 65 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -1.3109 -0.7887 -1.3109 49.0019
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
M059K CTRP2 -2.2885 -1.7188 -2.2885 55.5151
KNS-60 CTRP2 -1.98 -0.2813 -1.98 53.4592
SF268 CTRP2 -1.8683 3.3814 -2.0364 52.4895
YH-13 CTRP2 -1.578 3.8972 -1.8016 50.7083
SF539 CTRP2 -1.5479 -0.3968 -1.5479 50.5807
SNB-75 CTRP2 -0.9394 1.9245 -0.9517 46.5497
LN-229 CTRP2 -0.9263 4.1443 -1.1411 46.7071
SNU-466 CTRP2 -0.7909 -0.0514 -0.7909 45.538
CAS-1 CTRP2 -0.4763 4.9874 -0.8136 44.0672
SNU-489 CTRP2 -0.2163 0.3564 -0.2163 41.7094
SNU-1105 CTRP2 -0.0167 2.7027 -0.4067 20.8091
LN-18 CTRP2 0.5321 1.3879 0.5321 36.724
ONS-76 CTRP2 0.6713 4.5935 0.387 32.2113
DK-MG CTRP2 1.324 8.9068 -0.0967 35.5265
Hs 683 CTRP2 1.347 8.0833 0.2459 34.5952
Daoy CTRP2 1.8296 5.3438 1.6152 28.8052
SW1088 CTRP2 1.9573 7.6423 1.0644 30.2074
U-118MG CTRP2 2.5081 12.5067 -0.4591 32.6836
DBTRG-05MG CTRP2 2.6067 8.0425 1.6063 26.4168
SNU-626 CTRP2 2.6956 8.304 1.5958 26.19
42-MG-BA CTRP2 2.9533 9.666 1.2838 26.4977
SNU-738 CTRP2 2.9932 8.5328 1.8141 24.5647
KALS-1 CTRP2 3.1988 11.7916 0.5549 28.0895
GaMG CTRP2 4.2492 11.9121 1.5068 22.3266
8-MG-BA CTRP2 4.3492 10.4075 2.3279 19.0879
SF126 CTRP2 4.4954 8.387 3.4211 14.4268
Becker CTRP2 4.8458 14.2777 0.8906 22.9703
GB-1 CTRP2 4.9779 8.5219 3.8339 11.5759
U-87MG ATCC CTRP2 5.1336 11.9897 0.9707 12.6375
TM-31 CTRP2 5.6345 9.0158 4.2047 8.5614
GOS-3 CTRP2 6.0226 16.8822 0.6073 21.3463
CCF-STTG1 CTRP2 6.0838 15.1078 1.5455 18.1425
GMS-10 CTRP2 6.656 19.0569 0.0406 21.7905
SNU-201 CTRP2 6.7717 9.7777 4.7437 4.5253
SF295 CTRP2 6.806 17.7575 0.8098 19.2023
NMC-G1 CTRP2 7.1406 9.3614 5.186 1.9609
KNS-81 CTRP2 7.2809 13.5317 3.2746 9.3998
KG-1-C CTRP2 7.8315 15.0791 2.9159 9.9412
T98G CTRP2 8.0648 20.3807 0.4825 18.0093
U-251MG CTRP2 8.1651 19.8145 0.8369 16.7521
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 -2.806 -1.142 -2.806 58.9613
JHUEM-7 CTRP2 -2.4731 2.0141 -2.5353 56.3988
AN3-CA CTRP2 -2.3709 -1.2122 -2.3709 56.0637
HEC-151 CTRP2 -2.3614 -1.0957 -2.3614 56.0009
EN CTRP2 -2.2467 0.4962 -2.2499 55.209
HEC-6 CTRP2 -1.9534 0.4012 -1.9547 53.2765
RL95-2 CTRP2 -1.5217 -0.0429 -1.5218 46.8669
HEC-265 CTRP2 -1.135 0.9043 -1.1359 47.8318
ESS-1 CTRP2 -0.7517 1.7149 -0.757 45.2894
HEC-1-B CTRP2 -0.733 3.0432 -0.8483 41.554
HEC-59 CTRP2 -0.669 2.9926 -0.7273 44.8453
MFE-319 CTRP2 -0.6297 2.028 -0.6394 44.488
MFE-296 CTRP2 0.4806 6.7165 -0.2236 38.8918
HEC-108 CTRP2 0.8179 4.8492 0.6168 35.449
HEC-251 CTRP2 1.0119 7.1525 0.2141 35.8568
KLE CTRP2 1.2524 11.3125 -1.1831 37.994
HEC-1-A CTRP2 2.7383 11.4796 0.2456 30.2462
HEC-50B CTRP2 3.9695 10.4972 1.9181 21.5608
JHUEM-3 CTRP2 4.3168 9.6769 2.6441 17.9482
EFE-184 CTRP2 5.5505 8.7933 4.2393 8.5972
Ishikawa (Heraklio) 02 ER- CTRP2 0.9933 5.2195 0.7334 34.474
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-3 CTRP2 0.283 4.3814 0.1203 38.85
KMRC-1 CTRP2 0.5461 2.7863 0.5368 36.661
TUHR4TKB CTRP2 1.1939 5.1962 0.956 33.0874
BFTC-909 CTRP2 1.6271 10.4804 -0.435 35.2968
TUHR10TKB CTRP2 1.7197 5.9552 1.3488 30.0566
SNU-1272 CTRP2 3.2858 7.9758 2.3514 21.7831
UO-31 CTRP2 3.3672 11.4177 0.8957 26.6031
786-O CTRP2 3.4001 6.3201 3.0788 18.7507
VMRC-RCW CTRP2 3.5002 6.7227 3.057 18.5353
RCC10RGB CTRP2 4.0464 8.7831 2.7894 18.0659
KMRC-2 CTRP2 4.3242 11.8427 1.6111 21.78
OS-RC-2 CTRP2 4.5584 13.0146 0.6474 20.0236
A-498 CTRP2 5.4964 9.4734 3.8542 10.3173
Caki-2 CTRP2 6.3698 11.2241 3.7205 9.1439
VMRC-RCZ CTRP2 6.7459 17.498 0.8912 19.0555
ACHN CTRP2 6.9174 11.9134 3.8019 7.8553
KMRC-20 CTRP2 7.0913 12.9037 3.4434 9.0303
Caki-1 CTRP2 7.3002 9.8056 5.0787 2.1802
TUHR14TKB CTRP2 10.2276 26.9103 -1.1412 19.1378
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CL-34 CTRP2 -4.4014 -1.2982 -4.4032 69.2329
MDST8 CTRP2 -2.6622 -0.6586 -2.6623 57.9987
SNU-C1 CTRP2 -2.1211 -0.3542 -2.1212 54.399
SNU-175 CTRP2 -2.0746 4.8321 -2.517 53.3987
SW48 CTRP2 -2.0043 0.1889 -2.006 50.3106
OUMS-23 CTRP2 -1.8489 -0.7535 -1.8489 52.5862
SNU-C5 CTRP2 -1.773 4.1209 -2.0493 51.8413
KM12 CTRP2 -0.9584 3.1484 -1.0446 46.7736
LS123 CTRP2 -0.8262 0.8707 -0.8264 45.7732
RKO CTRP2 -0.7689 1.5319 -0.7721 45.399
SNU-503 CTRP2 -0.1752 29.101 -11.004 47.6516
LS180 CTRP2 -0.0234 3.4303 -0.0883 40.6077
NCI-H508 CTRP2 0.0047 3.5778 -0.0727 40.4545
SNU-61 CTRP2 0.0466 3.1036 0.0098 40.0673
GP2d CTRP2 0.1484 4.1138 0.0158 39.653
COLO201 CTRP2 0.2133 5.3234 -0.1378 39.7648
SNU-407 CTRP2 0.3433 3.768 0.2649 38.2196
LS513 CTRP2 0.4473 1.3156 0.4473 32.8125
NCI-H747 CTRP2 0.614 7.7152 -0.4097 38.7734
COLO205 CTRP2 0.6278 5.5493 0.0776 33.3888
LoVo CTRP2 0.7875 4.5291 0.6388 35.4914
SNU-1033 CTRP2 0.866 9.3077 -0.7417 38.5029
T84 CTRP2 0.8819 3.795 0.8289 34.5664
LS411N CTRP2 1.3137 6.5955 0.4646 29.6883
SW1463 CTRP2 1.6722 5.6396 1.377 30.1184
SK-CO-1 CTRP2 1.7632 7.7149 0.4975 28.0951
SW948 CTRP2 1.8673 10.0577 -0.0043 33.5152
CCK-81 CTRP2 1.8812 3.9829 1.8569 27.8169
COLO 320 CTRP2 2.3722 4.365 2.3411 24.5694
SW620 CTRP2 2.4088 5.9648 2.0982 25.2955
SNU-C4 CTRP2 2.4471 4.5659 2.4019 24.1182
HT-55 CTRP2 2.7747 7.9414 1.8246 25.1596
NCI-H716 CTRP2 2.8802 6.7408 2.3787 22.8556
SW1417 CTRP2 2.9923 10.411 0.9891 27.3394
COLO 678 CTRP2 3.0821 15.585 -1.3742 33.1059
CW-2 CTRP2 3.1795 7.6317 2.3764 21.9913
LS1034 CTRP2 3.4658 6.9212 2.9501 19.0333
DLD-1 CTRP2 3.4694 7.4 2.3891 15.6581
CL-11 CTRP2 3.4933 8.3202 2.4251 20.932
C2BBe1 CTRP2 3.5989 17.2375 -1.7013 32.4763
HCT 15 CTRP2 3.783 6.2194 3.5266 15.9692
HCC-56 CTRP2 3.8953 8.0325 2.9652 17.7809
HCT 8 CTRP2 6.0292 8.7144 4.6967 5.6941
RCM-1 [Human ESC] CTRP2 6.1123 15.27 1.4881 18.2854
HCT 116 CTRP2 7.9176 17.2811 1.9004 13.5844
HT-29 CTRP2 10.1504 20.9409 1.6771 11.1194
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-6 CTRP2 -2.8381 0.6516 -2.8499 58.9951
SNU-182 CTRP2 -2.2517 0.5814 -2.2558 55.2365
JHH-1 CTRP2 -2.238 -1.7766 -2.238 55.1788
SNU-398 CTRP2 -1.6772 0.6608 -1.6787 51.4396
SNU-387 CTRP2 -0.7145 5.581 -1.2106 45.7103
SNU-886 CTRP2 0.0457 4.506 -0.1554 40.4921
SK-HEP-1 CTRP2 0.1641 3.545 0.0982 39.3699
SNU-423 CTRP2 0.248 4.1142 0.1221 38.9809
HLF CTRP2 0.6648 8.7533 -0.738 39.2248
PLC/PRF/5 CTRP2 0.6988 6.9315 -0.0538 37.6697
SNU-475 CTRP2 0.8676 4.7577 0.687 35.0598
Hep-G2 CTRP2 1.1499 8.8938 -0.2763 36.5413
JHH-2 CTRP2 1.6259 7.1538 0.8795 31.8597
JHH-6 CTRP2 1.8909 5.1949 1.7121 28.2772
Hep 3B2.1-7 CTRP2 2.1084 8.3251 0.1562 23.4761
SNU-878 CTRP2 2.2725 4.3662 2.2368 25.249
JHH-4 CTRP2 2.2798 5.1249 2.1456 25.5373
HuH-1 CTRP2 2.8065 7.4035 2.0648 24.2098
Li-7 CTRP2 3.5447 7.3546 2.4853 15.0447
JHH-5 CTRP2 5.6819 17.472 0.0258 23.7475
SNU-449 CTRP2 6.0493 9.7087 4.2163 7.6734
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 133 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1573 CTRP2 -3.4132 3.6847 -3.7417 60.5812
LCLC-97TM1 CTRP2 -3.3518 0.012 -3.3584 62.3637
EPLC-272H CTRP2 -3.02 0.3495 -3.0283 60.2064
COR-L279 CTRP2 -3.0081 4.5242 -3.4652 58.1819
NCI-H1975 CTRP2 -2.861 -1.1604 -2.861 56.4239
NCI-H1341 CTRP2 -2.7614 2.6438 -2.8949 57.8505
DV-90 CTRP2 -2.5875 -0.4281 -2.5878 57.4977
NCI-H1694 CTRP2 -2.429 -0.9936 -2.429 56.4505
DMS 273 CTRP2 -2.3822 -1.6472 -2.3822 56.139
HCC44 CTRP2 -2.3199 0.382 -2.3227 55.6967
NCI-H810 CTRP2 -2.3043 1.0091 -2.3162 55.5394
HCC827 CTRP2 -2.2695 0.9171 -2.2788 55.3243
NCI-H2029 CTRP2 -2.2257 -1.2227 -2.2257 55.0969
NCI-H838 CTRP2 -2.188 -1.1357 -2.188 54.8457
DMS 114 CTRP2 -1.9925 -0.4274 -1.9925 53.5427
NCI-H1105 CTRP2 -1.9802 -0.1562 -1.9803 53.4603
NCI-H2087 CTRP2 -1.796 5.636 -2.404 51.795
NCI-H1623 CTRP2 -1.7155 1.884 -1.744 51.6632
MOR/CPR CTRP2 -1.6005 -0.8492 -1.6005 50.9313
NCI-H211 CTRP2 -1.533 -0.0412 -1.533 50.4814
NCI-H526 CTRP2 -1.4781 0.3725 -1.4783 50.1161
NCI-H520 CTRP2 -1.455 0.2836 -1.4552 49.9623
NCI-H2110 CTRP2 -1.3772 0.1865 -1.3773 49.4441
LUDLU-1 CTRP2 -1.3429 3.9597 -1.559 49.2821
NCI-H1703 CTRP2 -1.2917 0.706 -1.2922 48.8745
NCI-H841 CTRP2 -1.2833 0.9778 -1.285 48.8201
NCI-H522 CTRP2 -1.2382 1.9513 -1.2573 48.5347
HARA [Human squamous cell lung carcinoma] CTRP2 -1.2304 0.7379 -1.2321 44.7923
NCI-H292 CTRP2 -1.1888 1.2999 -1.1926 48.1933
LK2 CTRP2 -1.1831 1.9176 -1.1999 48.169
NCI-H661 CTRP2 -1.134 2.1942 -1.1603 47.8541
NCI-H1184 CTRP2 -1.1305 1.0772 -1.1321 47.8029
NCI-H1092 CTRP2 -1.1052 6.7736 -1.9689 48.1525
SK-MES-1 CTRP2 -1.0761 2.9226 -1.1474 47.5199
PC-14 CTRP2 -1.0307 0.1209 -1.0307 47.1355
NCI-H2009 CTRP2 -1.0061 0.1242 -1.0061 50.4527
NCI-H446 CTRP2 -0.9981 0.2692 -0.9981 46.9183
ChaGo-K-1 CTRP2 -0.888 2.3423 -0.9141 46.232
HCC2279 CTRP2 -0.8685 0.3573 -0.8685 46.0549
NCI-H1339 CTRP2 -0.7311 1.613 -0.7348 45.1483
NCI-H1734 CTRP2 -0.6194 1.3047 -0.6203 44.3977
RERF-LC-MS CTRP2 -0.604 1.0789 -0.6043 44.2934
SK-LU-1 CTRP2 -0.5942 1.1086 -0.5945 44.2283
NCI-H1581 CTRP2 -0.583 0.3954 -0.583 40.1668
NCI-H2126 CTRP2 -0.5558 0.0332 -0.5558 43.9714
NCI-H650 CTRP2 -0.4655 3.1151 -0.6536 35.5534
NCI-H1666 CTRP2 -0.4565 4.0783 -0.6262 43.666
NCI-H524 CTRP2 -0.4266 2.0865 -0.4346 43.1332
NCI-H1563 CTRP2 -0.3706 3.4232 -0.4527 42.9356
NCI-H1651 CTRP2 -0.3486 5.6767 -0.8356 43.5132
NCI-H2141 CTRP2 -0.2901 20.5052 -8.0044 44.5589
LCLC-103H CTRP2 -0.197 1.3392 -0.2 32.8343
VMRC-LCD CTRP2 -0.1709 4.6794 -0.4206 41.9914
LXF 289 CTRP2 -0.1408 2.0871 -0.1453 41.2207
COLO 668 CTRP2 -0.1179 5.4994 -0.5401 41.9919
HCC95 CTRP2 -0.0764 2.6386 -0.0937 40.8294
NCI-H1838 CTRP2 -0.075 5.6346 -0.5266 41.7816
NCI-H2196 CTRP2 -0.0562 6.6816 -0.7977 42.1735
Lu-99 CTRP2 -0.0026 4.2006 -0.2583 36.8413
HCC4006 CTRP2 0.0038 8.1768 -1.2325 42.5735
NCI-H2170 CTRP2 0.0217 6.6291 -0.6969 41.6763
CAL-12T CTRP2 0.0437 6.3731 -0.597 41.4071
HCC1438 CTRP2 0.0943 3.7205 0.0069 39.8901
NCI-H647 CTRP2 0.2395 9.4293 -1.4541 41.9562
NCI-H358 CTRP2 0.4362 7.106 -0.667 36.2273
NCI-H1915 CTRP2 0.6286 10.1847 -1.3491 40.3839
SBC-5 CTRP2 0.6508 1.0707 0.6508 35.9327
HCC2108 CTRP2 0.7833 6.1604 0.2707 36.5465
Sq-1 CTRP2 0.8073 5.9835 0.3456 36.2576
NCI-H1755 CTRP2 0.8395 5.9542 0.3886 36.0224
NCI-H2030 CTRP2 0.8399 3.5474 0.8044 34.7893
RERF-LC-Ad2 CTRP2 0.85 9.7296 -0.9292 38.9055
NCI-H2122 CTRP2 0.8838 5.6845 0.5065 35.5321
NCI-H1869 CTRP2 0.9416 7.8167 -0.0923 36.8621
HCC1833 CTRP2 0.9826 6.5976 0.3599 35.579
HCC1588 CTRP2 1.0358 3.872 0.9836 33.5398
HCC78 CTRP2 1.0834 5.8158 0.4889 30.3959
RERF-LC-A1 CTRP2 1.1005 3.6573 1.0677 33.0456
NCI-H889 CTRP2 1.2434 3.9203 1.1969 32.1396
NCI-H2342 CTRP2 1.2784 9.7756 -0.4984 36.5837
Calu-3 CTRP2 1.3078 12.3724 -1.598 38.5123
NCI-H1299 CTRP2 1.3174 4.2132 1.2463 31.7283
NCI-H2228 CTRP2 1.3281 6.5078 0.7638 33.2145
NCI-H1395 CTRP2 1.3698 5.6186 1.0525 32.182
NCI-H2106 CTRP2 1.4035 8.3371 -0.14 31.3358
NCI-H1155 CTRP2 1.5794 3.8 1.5159 24.9617
NCI-H1792 CTRP2 1.6563 7.3484 0.8453 31.8625
NCI-H441 CTRP2 1.9304 7.8104 0.9733 30.5784
DMS 53 CTRP2 1.9535 4.3356 1.9048 27.4181
NCI-H1793 CTRP2 1.9536 8.6914 0.6559 31.4577
EKVX CTRP2 1.9717 7.9574 0.9623 30.4806
NCI-H69 CTRP2 1.9981 8.7531 0.678 31.2519
NCI-H2023 CTRP2 2.061 6.518 1.5592 28.2536
COR-L95 CTRP2 2.0762 10.116 0.1864 32.3717
NCI-H727 CTRP2 2.0793 7.0993 1.0835 24.9727
NCI-H2405 CTRP2 2.1266 9.1872 0.226 27.8823
NCI-H1373 CTRP2 2.1661 8.4544 0.9757 29.8266
EBC-1 CTRP2 2.3847 8.8738 1.0352 28.9687
NCI-H322 CTRP2 2.4379 10.2644 0.4925 30.4345
NCI-H196 CTRP2 2.4511 9.9937 0.6252 30.013
SHP-77 CTRP2 2.5295 3.9024 2.5076 18.0291
HCC366 CTRP2 2.5964 8.8903 0.8328 24.3629
NCI-H1355 CTRP2 2.6971 9.8641 0.9343 28.3557
A-549 CTRP2 2.6985 9.2155 1.2181 27.4479
Lu-65 CTRP2 2.9926 12.8893 -0.1648 30.6168
LC-1/sq-SF CTRP2 3.1606 12.4438 0.2096 29.1729
NCI-H2085 CTRP2 3.1616 11.6207 0.5987 28.0618
SW1271 CTRP2 3.3313 12.1348 0.5219 27.8291
NCI-H1944 CTRP2 3.3908 11.7807 0.7475 26.9968
HCC2935 CTRP2 3.3995 11.0074 1.1197 25.8031
NCI-H460 CTRP2 3.5457 8.1027 2.5716 20.2359
LOU-NH91 CTRP2 3.5682 10.3399 1.5973 23.7456
COR-L105 CTRP2 3.7855 11.513 1.2572 24.3373
KNS-62 CTRP2 3.8413 10.736 1.6803 22.7412
NCI-H1385 CTRP2 3.8529 11.2884 1.4294 23.5838
HOP-62 CTRP2 3.9258 12.8456 0.7494 25.6076
HCC1195 CTRP2 3.9514 10.6112 1.8464 21.8667
NCI-H1650 CTRP2 3.9906 9.0733 2.6015 18.9377
HCC15 CTRP2 3.9953 11.4592 0.9256 20.3103
T3M-10 CTRP2 4.222 14.1343 0.3957 25.9383
SW1573 CTRP2 4.2571 9.5249 2.6572 18.0453
Calu-6 CTRP2 4.3526 12.5789 1.2787 22.8545
NCI-H226 CTRP2 4.6874 11.5371 2.0988 19.1454
NCI-H2172 CTRP2 4.8818 8.916 3.5533 12.9481
DMS 454 CTRP2 5.3167 12.0508 2.4151 16.5281
Calu-1 CTRP2 5.7781 13.6599 2.0125 17.0795
RERF-LC-Ad1 CTRP2 5.8013 13.2728 2.2257 16.2341
BEN CTRP2 6.384 10.3497 3.4079 5.0137
NCI-H2286 CTRP2 7.5927 11.8348 4.3155 4.7632
HCC1171 CTRP2 7.8114 18.0763 1.4301 15.3944
NCI-H2291 CTRP2 8.1906 21.1974 0.1737 18.7152
HOP-92 CTRP2 8.5229 24.0762 -0.9984 21.3239
Hs 888.Lu CTRP2 2.6693 16.6488 -2.2792 35.7834
⏷ Show the Full List of 133 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 -2.1302 2.1726 -2.1895 54.2678
Aska-SS CTRP2 -1.1814 3.9328 -1.3814 48.282
TE 617.T CTRP2 -3.4454 -0.8457 -3.4461 63.1508
BT-12 CTRP2 -2.9372 -1.385 -2.9372 59.8359
Tm87-16 CTRP2 -2.2988 8.2758 -3.7549 53.6382
G-402 CTRP2 -2.1552 -1.2098 -2.1552 54.6271
GCT CTRP2 -1.9998 0.9836 -2.007 53.5622
Rh41 CTRP2 -1.5636 -0.6527 -1.5636 50.6855
SW982 CTRP2 -1.4225 6.255 -2.1629 49.7986
TTC-709 CTRP2 -0.4705 12.4782 -3.4647 46.294
A-204 CTRP2 -0.071 7.3876 -1.0393 42.6074
RD CTRP2 0.0576 7.9635 -1.0982 42.1657
BT-16 CTRP2 0.1936 12.3874 -2.7411 43.5396
MES-SA CTRP2 0.21 2.5956 0.1999 38.9018
RKN CTRP2 2.4812 6.7105 1.9554 25.5755
HT-1080 CTRP2 2.8278 11.1106 0.5046 29.2659
TE 441.T CTRP2 3.762 4.3352 3.762 15.2056
KYM-1 CTRP2 4.0016 15.2409 -0.3504 28.5018
SK-LMS-1 CTRP2 5.9235 12.9542 2.4882 14.9806
SK-UT-1 CTRP2 6.6304 19.4917 -0.1973 22.5017
Rh18 CTRP2 8.0374 15.6669 2.7759 10.1633
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -1.9473 3.7299 -2.1717 52.9037
COV434 CTRP2 -3.5148 -2.1363 -3.5148 63.6843
A2780 CTRP2 -3.0742 0.0206 -3.0786 60.6221
COV644 CTRP2 -2.8676 -1.6153 -2.8676 59.3728
COV362 CTRP2 -2.1655 6.0822 -2.9256 53.5709
OC 314 CTRP2 -2.057 -1.0699 -2.057 53.9724
OVK18 CTRP2 -1.3709 -0.5902 -1.3709 49.4016
SNU-119 CTRP2 -1.2099 1.646 -1.2196 48.3395
OVCAR-4 CTRP2 -0.792 1.8201 -0.7995 45.5619
TOV-112D CTRP2 -0.6068 2.5491 -0.6345 44.3757
SNU-8 CTRP2 -0.5522 3.2583 -0.6279 44.1124
JHOM-1 CTRP2 -0.4939 6.5059 -1.2223 44.6877
JHOC-5 CTRP2 -0.3063 2.5239 -0.3248 42.361
MCAS CTRP2 0.2469 4.3481 0.0868 39.0795
OAW28 CTRP2 0.2975 5.8031 -0.1632 39.4827
ONCO-DG-1 CTRP2 0.3114 4.6393 -0.0162 34.8741
IGROV-1 CTRP2 0.3169 6.0878 -0.2181 39.5269
Caov-3 CTRP2 0.7268 8.1609 -0.4487 38.4311
OVSAHO CTRP2 1.1576 4.4344 0.9522 28.4888
OV7 CTRP2 1.2301 11.1767 -1.1466 38.0025
TYK-nu CTRP2 1.9099 10.7631 -0.2677 34.0193
Kuramochi CTRP2 2.0533 8.5114 0.4544 27.3341
SNU-840 CTRP2 3.7642 10.8389 1.5565 23.3741
OVTOKO CTRP2 3.9144 7.439 2.8115 12.6615
TOV-21G CTRP2 3.9331 11.7033 1.3078 23.7918
FU-OV-1 CTRP2 4.4927 20.6262 -2.5769 32.0907
OV56 CTRP2 4.5277 6.8149 4.1296 11.5566
RMG-I CTRP2 4.6503 12.941 1.375 21.8229
OV-90 CTRP2 4.9841 12.4472 1.9214 19.1222
OVCAR-8 CTRP2 5.1167 10.6333 2.9374 14.9071
JHOS-2 CTRP2 5.1668 15.4758 0.5788 23.225
EFO-27 CTRP2 5.5779 16.4483 0.4488 22.738
EFO-21 CTRP2 5.6096 15.3895 1.0047 20.9369
SK-OV-3 CTRP2 5.8148 11.9651 2.8906 13.6117
OAW42 CTRP2 6.5413 11.7805 3.5792 9.418
OVCAR-5 CTRP2 6.869 20.295 -0.4059 22.6219
HEY A8 CTRP2 7.7805 16.1581 2.3513 12.1641
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 0.952 17.7842 -4.4675 42.7485
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JL-1 CTRP2 -1.5484 1.0664 -1.5524 50.5821
NCI-H28 CTRP2 -1.0716 0.3648 -1.0717 43.6541
MSTO-211H CTRP2 -0.9666 3.4555 -1.0865 46.864
NCI-H2452 CTRP2 -0.661 1.4262 -0.6626 44.6768
NCI-H2052 CTRP2 3.9207 8.5938 2.7466 18.5592
ACC-MESO-1 CTRP2 6.441 13.4608 2.6613 13.3026
IST-Mes1 CTRP2 8.0511 16.5755 2.3431 11.766
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 CTRP2 5.5662 12.6869 2.3167 16.3744
PaCa-3 CTRP2 8.9211 20.3685 1.1152 14.6797
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -1.4519 -0.8783 -1.4519 49.9416
A-253 CTRP2 4.0661 12.5586 1.0207 24.4034
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 CTRP2 -3.3379 -1.711 -3.3379 62.5036
OCUM-1 CTRP2 -3.2225 9.6568 -5.243 56.5982
SNU-16 CTRP2 -2.721 -1.4668 -2.721 58.3962
IM95 CTRP2 -2.6894 2.1872 -2.7744 57.6222
HGC-27 CTRP2 -2.6706 -0.6017 -2.6708 58.0532
SNU-5 CTRP2 -1.9608 0.2157 -1.9614 53.3282
SNU-719 CTRP2 -1.9075 1.1141 -1.916 52.9512
SNU-1 CTRP2 -1.7033 0.349 -1.7038 51.6153
23132/87 CTRP2 -1.5523 1.0778 -1.5565 54.3342
ECC10 CTRP2 -1.5425 0.2266 -1.5427 50.5451
SNU-620 CTRP2 -1.3698 0.7765 -1.3725 45.7893
GSS CTRP2 -1.1426 2.5697 -1.2273 44.3498
SH-10-TC CTRP2 -1.1038 1.337 -1.1074 47.628
GSU CTRP2 -0.9011 -0.2016 -0.9011 46.2721
HuG1-N CTRP2 -0.7751 5.3619 -1.2232 46.0193
AGS CTRP2 -0.7002 0.1059 -0.7002 44.9335
LMSU CTRP2 -0.6262 4.2913 -0.8426 44.8239
SNU-668 CTRP2 -0.5296 0.0917 -0.5296 43.7971
NUGC-3 CTRP2 -0.4707 1.29 -0.4712 43.4062
NUGC-4 CTRP2 -0.3887 3.9344 -0.5329 43.1807
ECC12 CTRP2 -0.0253 0.7791 -0.0253 40.4371
NCI-N87 CTRP2 0.0834 8.781 -1.37 42.4427
MKN74 CTRP2 0.3042 8.0552 -0.8649 40.8184
SNU-216 CTRP2 0.7863 8.4189 -0.4809 38.2775
SNU-601 CTRP2 2.5276 10.4463 0.503 30.1391
MKN7 CTRP2 3.4241 12.1225 0.6177 27.2992
Hs 746.T CTRP2 5.6513 8.4731 4.4887 7.3395
MKN45 CTRP2 6.6999 7.8807 4.6597 0.1723
MKN1 CTRP2 7.5365 12.6342 3.8949 6.5164
KE-39 CTRP2 9.2771 22.4397 0.3598 16.4752
SNG-M CTRP2 1.7344 7.4249 0.9027 31.4312
SNU-685 CTRP2 3.4491 12.7485 0.3429 28.0326
SNU-1077 CTRP2 4.521 11.0883 1.576 16.5039
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 -2.3507 1.3701 -2.3744 55.784
TT CTRP2 -2.0499 -0.7183 -2.0499 53.9255
FTC-238 CTRP2 -1.3735 1.7966 -1.3903 49.4254
8305C CTRP2 -1.1779 0.3856 -1.1779 48.1159
B-CPAP CTRP2 -0.5183 1.1736 -0.5186 43.7226
CAL-62 CTRP2 -0.2008 6.9182 -1.0284 43.1417
ML-1 [Human leukemia] CTRP2 0.3702 8.1326 -0.8219 40.4885
BHT-101 CTRP2 0.4268 1.1329 0.4268 37.4252
8505C CTRP2 0.8581 6.6055 0.2218 36.3974
CGTH-W-1 CTRP2 1.4625 7.9173 0.4315 33.7048
FTC-133 CTRP2 4.4727 9.6834 2.7925 16.9843
TT2609-C02 CTRP2 9.3252 20.0096 1.5707 12.5913
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-4 CTRP2 -3.6805 6.0485 -4.5697 60.0892
YD-10B CTRP2 -3.3652 -2.8867 -3.3652 62.688
SCC-25 CTRP2 -3.1208 -1.3202 -3.1209 61.0559
PE/CA-PJ34 (clone C12) CTRP2 -2.3372 -1.8995 -2.3372 55.8394
PE/CA-PJ49 CTRP2 -2.323 -1.7757 -2.323 55.7446
BHY CTRP2 -2.2716 -0.1072 -2.2721 55.3967
CAL-33 CTRP2 -2.23 0.3325 -2.2319 55.1073
Detroit 562 CTRP2 -2.2144 0.1449 -2.2204 48.286
BICR 22 CTRP2 -2.1353 2.3996 -2.2123 54.2598
BICR 16 CTRP2 -1.8246 1.9235 -1.8581 52.3651
BICR 56 CTRP2 -1.5196 -0.1817 -1.5196 50.3925
SNU-899 CTRP2 -1.4951 3.1882 -1.6156 50.2159
BICR 6 CTRP2 -0.9138 4.4203 -1.1755 46.6757
PE/CA-PJ15 CTRP2 -0.8572 3.7243 -1.0042 46.1963
BICR 31 CTRP2 -0.8189 6.7417 -1.6472 46.5955
SNU-1214 CTRP2 -0.7105 0.3431 -0.7105 45.0021
HSC-3 CTRP2 -0.5636 0.0143 -0.5636 35.6314
HSC-2 CTRP2 -0.3529 1.695 -0.3549 42.6256
SNU-1076 CTRP2 0.0811 1.9165 0.0798 39.7326
YD-8 CTRP2 1.1398 5.9197 0.7254 33.9826
BICR 18 CTRP2 1.2899 6.0799 0.846 33.098
SNU-1066 CTRP2 1.8215 4.5726 1.6438 23.659
SCC-9 CTRP2 2.2073 10.1311 0.3147 31.6252
SNU-1041 CTRP2 2.7102 7.9847 1.3581 22.0252
HSC-4 CTRP2 2.8681 10.9017 0.6407 28.7546
PE/CA-PJ41 (clone D2) CTRP2 3.1371 27.2076 -7.0481 40.0298
FaDu CTRP2 3.8237 15.6437 -0.7118 29.8169
SNU-46 CTRP2 5.6698 16.8846 0.3091 22.9604
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V CTRP2 -1.6602 3.4151 -1.819 51.2294
BFTC-905 CTRP2 -1.4455 2.7373 -1.5185 49.9024
RT-112 CTRP2 -1.3163 0.3212 -1.3164 49.0383
CAL-29 CTRP2 -1.3074 6.1588 -2.0103 49.1807
JMSU-1 CTRP2 -0.9159 0.2024 -0.9159 46.3708
RT-4 CTRP2 -0.8701 0.1847 -0.8701 46.0655
5637 CTRP2 -0.8529 2.1822 -0.8716 45.9875
UM-UC-1 CTRP2 -0.8475 4.6502 -1.1473 46.3061
SCaBER CTRP2 -0.7556 0.93 -0.7558 45.303
KU-19-19 CTRP2 -0.3081 1.7962 -0.3152 38.2289
BC-3C CTRP2 -0.2145 6.9186 -1.0435 43.2222
U-BLC1 CTRP2 0.0401 7.3994 -0.9227 41.9713
253J CTRP2 0.2877 1.5608 0.2876 38.3524
SW1710 CTRP2 1.3519 7.0954 0.6021 33.6052
VM-CUB-1 CTRP2 1.5197 6.4691 0.7326 28.059
TCCSUP CTRP2 1.6084 8.6999 0.2869 33.6056
UM-UC-3 CTRP2 1.8985 7.797 0.9441 30.7708
HT-1197 CTRP2 2.7134 10.8831 0.4939 29.6237
639V CTRP2 3.0152 12.4435 -0.4577 27.4981
KMBC-2 CTRP2 3.3454 8.5717 2.1643 22.3094
J82 CTRP2 4.4003 13.9304 0.6595 24.7252
253J-BV CTRP2 5.402 15.2867 0.8776 21.7856
HT-1376 CTRP2 5.896 13.0775 2.4034 15.3635
T24 CTRP2 6.5144 14.214 2.3443 14.3891
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 0.3069 4.1053 0.1861 38.5797

References

1 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
2 Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br J Pharmacol. 2014 Jan;171(1):55-68. doi: 10.1111/bph.12408.