Details of the Drug

General Information of Drug (ID: DMD1HLC)

Drug Name
Floctafenine
Synonyms
floctafenine; 23779-99-9; Idarac; Novodolan; Diralgan; Idalon; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate; RU 15750; R 4318; Floctafeninum [INN-Latin]; Floctafenina [INN-Spanish]; 8-Trifluoromethyl-7-deschloroglafenine; C20H17F3N2O4; EINECS 245-881-4; BRN 0457808; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)-quinolin-4-yl)amino)benzoate; 2,3-Dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate; 4-(o-(2',3'-Dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline
Indication
Disease Entry ICD 11 Status REF
Acute pain MG31 Approved [1]
Arthritis FA20 Withdrawn from market [2]
ATC Code
N02BG04: Floctafenine
N02BG: Other analgesics and antipyretics
N02B: OTHER ANALGESICS AND ANTIPYRETICS
N02: ANALGESICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C20H17F3N2O4
Canonical SMILES
C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F
InChI
InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
InChIKey
APQPGQGAWABJLN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3360
ChEBI ID
CHEMBL31612
CAS Number
23779-99-9
UNII
O04HVX6A9Q
DrugBank ID
DB08976
TTD ID
D0AK5R
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

References

1 Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial). Trials. 2020 Oct 13;21(1):846.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015