Details of the Drug

General Information of Drug (ID: DMD1HLC)

Drug Name

Floctafenine

Synonyms

floctafenine; 23779-99-9; Idarac; Novodolan; Diralgan; Idalon; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate; RU 15750; R 4318; Floctafeninum [INN-Latin]; Floctafenina [INN-Spanish]; 8-Trifluoromethyl-7-deschloroglafenine; C20H17F3N2O4; EINECS 245-881-4; BRN 0457808; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)-quinolin-4-yl)amino)benzoate; 2,3-Dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate; 4-(o-(2',3'-Dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline

Indication

Disease Entry	ICD 11	Status	REF
Acute pain	MG31	Approved	[1]
Arthritis	FA20	Withdrawn from market	[2]
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ATC Code

N02BG04: Floctafenine

N02BG: Other analgesics and antipyretics

N02B: OTHER ANALGESICS AND ANTIPYRETICS

N02: ANALGESICS

N: NERVOUS SYSTEM

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C20H17F3N2O4
Canonical SMILES: C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F
InChI: 1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
InChIKey: APQPGQGAWABJLN-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 3360
ChEBI ID: CHEBI:31612
CAS Number: 23779-99-9
UNII: O04HVX6A9Q
DrugBank ID: DB08976
TTD ID: D0AK5R

Repurposed Drugs (RPD)

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References

1	Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial). Trials. 2020 Oct 13;21(1):846.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015