Details of the Drug

General Information of Drug (ID: DMDB3OK)

Drug Name
MLN-3126
Synonyms CCR9 antagonist (oral, Crohn's disease), Millennium
Indication
Disease Entry ICD 11 Status REF
Sjogren syndrome 4A43.20 Phase 1 [1]
Cross-matching ID
TTD ID
D0Q4CX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 9 (CCR9) TTIPS8B CCR9_HUMAN Antagonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Sjogren syndrome
ICD Disease Classification 4A43.20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-C chemokine receptor type 9 (CCR9) DTT CCR9 7.74E-01 0.02 0.22
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT02209506) Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants. U.S. National Institutes of Health.
2 Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29.