Details of the Drug

General Information of Drug (ID: DMDIPW8)

Drug Name
JNJ-38877605
Synonyms C-met inhibitor, Ortho Biotech Oncology Research & Development; C-met inhibitor (solid tumors), ORD/J&J PRD
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 377.3
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C19H13F2N7
IUPAC Name
6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
Canonical SMILES
CN1C=C(C=N1)C2=NN3C(=NN=C3C(C4=CC5=C(C=C4)N=CC=C5)(F)F)C=C2
InChI
InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3
InChIKey
JRWCBEOAFGHNNU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46911863
ChEBI ID
CHEBI:91417
CAS Number
943540-75-8
UNII
15UDG410PN
DrugBank ID
DB13113
TTD ID
D0YT8P
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Met (MET) DTT MET 1.08E-03 -0.24 -0.4
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 6.1632 11.686 2.0383 11.7122
CAL-78 GDSC1 3.4682 9.3681 1.0563 26.7569
CHSA8926 GDSC1 4.248 14.5027 -0.8302 31.0972
ES7 GDSC1 4.4109 7.7917 2.6606 12.6837
HuO-3N1 GDSC1 4.5443 11.5843 0.8744 23.4306
H-EMC-SS GDSC1 4.5845 7.177 3.1069 8.6597
HuO9 GDSC1 4.6849 9.832 1.8632 17.3028
ES1 GDSC1 5.0275 8.9166 2.5828 11.2016
MHH-ES-1 GDSC1 5.1658 7.6365 3.3042 5.43
HOS GDSC1 5.3014 7.367 3.5176 3.5501
CADO-ES1 GDSC1 5.3447 7.2991 3.5746 3.0586
ES8 GDSC1 5.3583 8.3695 3.0831 6.5697
EW-18 GDSC1 5.3664 8.0262 3.2511 5.3185
ES5 GDSC1 5.3934 10.9202 1.8675 14.9632
NOS-1 [Human HNSCC] GDSC1 5.4055 9.9146 2.3692 11.5868
EW-7 GDSC1 5.4585 11.6915 1.5362 16.7933
EW-24 GDSC1 5.4737 7.0681 3.7483 1.6875
G-292 clone A141B1 GDSC1 5.4861 7.8611 3.4028 3.9573
SK-ES-1 GDSC1 5.612 11.139 1.9196 13.9814
EW-16 GDSC1 5.8248 10.9118 2.1798 11.6916
ES6 GDSC1 5.8761 8.4354 3.3705 3.3994
SK-PN-DW GDSC1 6.0666 9.1175 3.1747 4.3319
CAL-72 GDSC1 6.1323 7.6621 3.8139 0.6235
EW-22 GDSC1 6.213 12.8109 1.5314 14.6617
EW-13 GDSC1 6.2232 12.8051 1.5413 14.5772
NY GDSC1 6.296 15.2134 0.4209 20.1434
EW-3 GDSC1 6.4636 11.6073 2.2719 9.4758
TC-71 GDSC1 6.6329 7.9681 3.894 0.1676
SaOS-2 GDSC1 6.648 14.4376 1.0468 16.1775
SJSA-1 GDSC1 6.7416 14.5079 1.0771 15.7825
EW-1 GDSC1 6.7771 8.5574 3.741 0.4777
ES4 GDSC1 6.8948 8.7266 3.7252 0.4654
MG-63 GDSC1 7.1877 16.5653 0.3926 17.993
U2OS GDSC1 7.5504 20.006 -1.0196 22.6153
A-673 GDSC1 10.1585 24.3398 -1.3415 18.4815
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 5.9451 8.3013 3.4667 2.6651
KMS-11 GDSC1 -7.8518 7.3777 -9.908 75.9627
SU-DHL-16 GDSC1 1.9221 6.6416 0.8409 35.6868
SU-DHL-6 GDSC1 3.3772 8.8658 1.2216 26.3022
SR GDSC1 4.4029 10.832 1.1341 22.6085
GDM-1 GDSC1 4.439 7.206 2.9763 10.1712
MV4-11 GDSC1 4.6322 10.9964 1.2396 21.2106
SU-DHL-8 GDSC1 4.7236 11.6669 0.9786 22.2752
DoHH2 GDSC1 4.726 7.0582 3.2742 6.9048
RCH-ACV GDSC1 4.7833 8.2151 2.7452 10.7746
SU-DHL-5 GDSC1 4.8063 6.9424 3.3901 5.7676
A3/Kawakami GDSC1 4.8121 8.4958 2.6281 11.5538
SUP-B15 GDSC1 4.8216 7.9508 2.9052 9.4436
NK-92MI GDSC1 4.8629 13.0258 0.4122 24.4895
SIG-M5 GDSC1 4.9338 6.1794 3.84 2.0731
A4/Fukuda GDSC1 4.9752 6.5748 3.6822 3.1117
MOLT-16 GDSC1 4.9785 7.6051 3.1902 6.7994
RPMI-8226 GDSC1 4.9978 10.0308 2.0093 15.292
QIMR-WIL GDSC1 5.0024 8.5316 2.7538 10.0208
Ramos.2G6.4C10 GDSC1 5.0289 7.36 3.3441 5.4925
Hs 445 GDSC1 5.0328 6.9846 3.5262 4.1188
OCI-M1 GDSC1 5.0537 7.9303 3.0853 7.3797
RPMI-8402 GDSC1 5.0606 7.1036 3.4881 4.3319
OCI-AML-5 GDSC1 5.0625 6.4428 3.7966 2.1061
RPMI-6666 GDSC1 5.1162 8.8367 2.6874 10.1667
Karpas-231 GDSC1 5.1745 9.4213 2.4432 11.7543
ML-2 GDSC1 5.21 7.8741 3.2203 5.9392
ATN-1 GDSC1 5.2194 10.8909 1.7521 16.2289
TUR GDSC1 5.2284 7.7279 3.3022 5.2851
ALL-PO GDSC1 5.2295 7.364 3.4743 4.0227
Farage GDSC1 5.2388 9.5478 2.4281 11.6668
SUP-T1 GDSC1 5.24 8.7998 2.7943 9.0191
KMS-12-BM GDSC1 5.2402 7.0104 3.644 2.7947
Karpas-45 GDSC1 5.2846 7.0635 3.646 2.6902
DB GDSC1 5.2847 8.0694 3.177 6.0668
Karpas-422 GDSC1 5.299 8.8559 2.8086 8.7482
SK-MM-2 GDSC1 5.3249 8.0072 3.2332 5.5514
Daudi GDSC1 5.3269 7.3631 3.5349 3.3728
SUP-M2 GDSC1 5.3361 6.801 3.7907 1.6464
Raji GDSC1 5.349 7.9094 3.2949 5.042
HDLM-2 GDSC1 5.3658 12.0343 1.2974 18.4501
P32/ISH GDSC1 5.395 12.0306 1.3213 18.2255
HEL GDSC1 5.4002 6.9798 3.7476 1.8099
HC-1 GDSC1 5.4241 10.2773 2.2053 12.6553
CESS GDSC1 5.4626 7.7877 3.4222 3.8719
VAL GDSC1 5.4819 7.5609 3.5365 3.0432
Karpas-299 GDSC1 5.4821 7.3906 3.6126 2.5346
DEL GDSC1 5.4954 13.2652 0.7866 20.7258
KOPN-8 GDSC1 5.5177 13.3107 0.781 20.6848
OCI-AML-2 GDSC1 5.5212 8.6778 3.044 6.4429
CTB-1 GDSC1 5.531 10.2736 2.2836 11.8136
MEG-01 GDSC1 5.5332 12.8204 1.0351 19.3512
BALL-1 GDSC1 5.5496 7.6301 3.5442 2.8607
MOLP-8 GDSC1 5.5596 7.2903 3.6981 1.8584
BC-1 GDSC1 5.5648 9.8394 2.5177 10.0992
ME1 GDSC1 5.5817 6.8487 3.8907 0.7686
DND-41 GDSC1 5.5875 8.1665 3.3239 4.291
L-1236 GDSC1 5.601 8.8058 3.0353 6.3109
LAMA-84 GDSC1 5.6011 8.8357 3.0213 6.4111
THP-1 GDSC1 5.6278 8.8252 3.0433 6.1892
TK [Human B-cell lymphoma] GDSC1 5.6304 12.5385 1.2465 17.9238
Jurkat GDSC1 5.6318 7.7205 3.5502 2.6708
K-562 GDSC1 5.6451 7.395 3.6977 1.7305
MOLT-13 GDSC1 5.6659 8.4272 3.2518 4.6259
HH [Human lymphoma] GDSC1 5.7434 11.7462 1.7174 14.8609
ALL-SIL GDSC1 5.792 14.8468 0.2288 22.402
SU-DHL-1 GDSC1 5.8099 6.8718 3.9759 0.2718
BL-41 GDSC1 5.8354 7.1403 3.8875 0.559
P30/OHK GDSC1 5.8374 12.0935 1.6153 15.2065
CA46 GDSC1 5.8375 9.9119 2.6666 8.342
SU-DHL-10 GDSC1 5.8532 6.9473 3.9654 0.2811
MC116 GDSC1 5.8605 6.6737 4.0625 0.0718
U-698-M GDSC1 5.8636 11.9247 1.7162 14.526
JURL-MK1 GDSC1 5.8944 7.691 3.6975 1.394
HT GDSC1 5.9289 11.0601 2.1797 11.4119
SKM-1 GDSC1 5.9334 7.0427 3.9617 0.2542
L-363 GDSC1 5.9402 7.5561 3.7725 0.9657
U266B1 GDSC1 5.9497 9.8465 2.7697 7.3523
OPM-2 GDSC1 5.9553 7.8648 3.6556 1.5432
NKM-1 GDSC1 5.9815 9.4758 2.9616 5.9525
HAL-01 GDSC1 6.0121 11.9066 1.829 13.4243
SU-DHL-4 GDSC1 6.0125 7.471 3.8363 0.6256
Sc-1 GDSC1 6.0226 8.6315 3.365 3.1735
IM-9 GDSC1 6.0416 7.1983 3.9471 0.2463
Loucy GDSC1 6.0424 7.6703 3.7729 0.8663
MY-M12 GDSC1 6.0426 13.1487 1.2474 16.728
HL-60 GDSC1 6.0532 7.2769 3.9236 0.3042
P31/FUJ GDSC1 6.0604 7.1656 3.9654 0.1954
ST486 GDSC1 6.0726 15.0053 0.3598 21.032
GA-10 GDSC1 6.0995 7.5329 3.8487 0.5178
BE-13 GDSC1 6.1014 8.0033 3.6683 1.3029
WSU-DLCL2 GDSC1 6.107 7.2395 3.9566 0.1988
SCC-3 GDSC1 6.1279 7.4261 3.8987 0.3395
RL GDSC1 6.1347 7.6126 3.8334 0.5494
BV-173 GDSC1 6.1559 16.0301 -0.083 22.6674
BC-3 GDSC1 6.1836 7.7073 3.818 0.5722
RC-K8 GDSC1 6.2174 7.7979 3.798 0.6227
WSU-NHL GDSC1 6.2258 7.7642 3.8139 0.5588
MHH-PREB-1 GDSC1 6.2267 7.6556 3.854 0.4233
697 GDSC1 6.2277 13.3563 1.2775 16.0535
NOMO-1 GDSC1 6.2346 14.8107 0.5735 19.6095
CTV-1 GDSC1 6.2569 8.3052 3.619 1.3774
Mono-Mac-6 GDSC1 6.2837 9.324 3.2047 3.7387
KE-37 GDSC1 6.2877 7.6411 3.8824 0.3103
KG-1 GDSC1 6.3047 8.3325 3.6299 1.2728
MOLM-13 GDSC1 6.3057 8.4163 3.597 1.4331
YT GDSC1 6.3221 7.9753 3.7745 0.637
Granta-519 GDSC1 6.3249 8.231 3.6785 1.0273
AMO1 GDSC1 6.4279 17.8011 -0.7532 24.428
JVM-2 GDSC1 6.4288 8.7163 3.5337 1.6146
Karpas-620 GDSC1 6.4325 14.9999 0.6233 18.8405
EJM GDSC1 6.4617 8.4847 3.6398 1.0745
Reh GDSC1 6.5066 13.5993 1.3534 14.8977
WIL2 NS GDSC1 6.5367 12.7307 1.7892 12.3058
EM-2 GDSC1 6.549 8.1526 3.799 0.4216
KCL-22 GDSC1 6.5543 8.491 3.6767 0.8421
RS4;11 GDSC1 6.5581 17.1893 -0.3567 22.6623
KY821 GDSC1 6.6027 12.6462 1.8726 11.6415
NU-DUL-1 GDSC1 6.6244 16.5797 -0.0101 21.1273
LC4-1 GDSC1 6.6245 8.6844 3.6328 0.964
H9 GDSC1 6.6429 14.7157 0.9091 16.8944
OCI-AML-3 GDSC1 6.6557 7.9181 3.9188 0.1226
KMOE-2 GDSC1 6.6676 8.304 3.7899 0.3908
PF-382 GDSC1 6.6753 9.121 3.4852 1.5845
RPMI-8866 GDSC1 6.7051 12.455 2.0285 10.4455
KM-H2 GDSC1 6.7066 8.4993 3.7347 0.5343
JVM-3 GDSC1 6.775 8.4802 3.7677 0.4027
P12-Ichikawa GDSC1 6.7795 8.1335 3.8891 0.1415
LP-1 GDSC1 6.7805 18.6336 -0.9027 24.0449
L-428 GDSC1 6.7998 8.2141 3.8689 0.1695
EB2 GDSC1 6.7999 8.4107 3.8014 0.3067
PL-21 GDSC1 6.8198 8.9326 3.6203 0.8629
ARH-77 GDSC1 6.8579 8.437 3.8133 0.2598
Jiyoye GDSC1 6.8947 8.868 3.6742 0.6221
MOLT-4 GDSC1 6.903 15.1343 0.8862 16.3527
MN-60 GDSC1 7.082 8.981 3.7053 0.4344
EHEB GDSC1 7.1487 9.2734 3.626 0.6328
L-540 GDSC1 7.2058 21.8037 -2.1475 26.7329
ROS-50 GDSC1 7.2065 16.4553 0.4584 17.6505
MLMA GDSC1 7.2382 8.7404 3.8433 0.1192
OCI-Ly19 GDSC1 7.2836 15.7142 0.8647 15.542
JJN-3 GDSC1 7.2921 16.7917 0.355 17.9112
Ku812 GDSC1 7.46 19.0011 -0.5955 21.3449
DG-75 GDSC1 7.4883 9.2437 3.7606 0.1879
GR-ST GDSC1 7.541 9.8789 3.5589 0.6301
CCRF-CEM GDSC1 7.6088 17.0259 0.4562 16.7213
VL51 GDSC1 7.8095 16.7133 0.7358 14.9742
JSC-1 GDSC1 7.9033 18.326 0.0327 17.8963
SUP-HD1 GDSC1 8.0106 19.5799 -0.495 19.7381
NB4 GDSC1 8.065 17.8206 0.379 16.0585
NALM-6 GDSC1 8.4627 20.456 -0.6099 19.2016
EoL-1 GDSC1 8.5301 17.6433 0.7561 13.3766
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 3.9623 8.3014 2.0251 18.9503
ESO-26 GDSC1 4.3748 7.7268 2.6634 12.7928
SK-GT-4 GDSC1 5.2886 9.3233 2.5739 10.4815
FLO-1 GDSC1 5.7063 13.1833 0.9854 19.0898
KYSE-50 GDSC1 5.8998 15.6425 -0.0832 23.3802
OACM5.1 C GDSC1 6.0061 13.0884 1.2507 16.812
HCE-4 GDSC1 6.6363 13.1257 1.6672 12.7825
KYAE-1 GDSC1 6.7487 14.0562 1.2984 14.5864
OACP4 C GDSC1 6.8119 9.0617 3.5681 1.0778
KYSE-220 GDSC1 6.9489 9.5584 3.4354 1.5403
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 6.1193 13.8122 0.9786 17.9401
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-10 GDSC1 2.022 3.9463 1.9037 29.4971
SJNB-12 GDSC1 2.3493 7.6607 0.8176 33.3234
CHP-212 GDSC1 4.6541 7.1453 3.1766 7.8899
GI-ME-N GDSC1 4.678 10.496 1.5264 19.4102
NB(TU)1 GDSC1 4.7812 18.29 -2.2831 33.1432
MHH-NB-11 GDSC1 4.9479 6.8171 3.5496 4.162
LA-N-6 GDSC1 4.9556 7.5788 3.1866 6.8928
SiMa GDSC1 4.9683 8.1308 2.9257 8.8362
IMR-5 GDSC1 5.0403 6.7172 3.6569 3.1425
SK-N-SH GDSC1 5.0834 9.4249 2.3739 12.5253
NB69 GDSC1 5.1305 7.8394 3.1829 6.4305
SJNB-7 GDSC1 5.5243 15.6419 -0.3699 25.555
SJNB-14 GDSC1 5.5983 7.2332 3.7421 1.5385
SK-N-FI GDSC1 5.6938 8.088 3.422 3.4015
Kelly GDSC1 5.984 7.4613 3.8281 0.681
SK-N-MC-IXC GDSC1 6.0161 7.1486 3.9552 0.2363
NB1 GDSC1 6.0264 11.2902 2.1355 11.4433
CHP-134 GDSC1 6.0602 12.9917 1.3364 16.1872
SK-N-DZ GDSC1 6.0783 7.6683 3.7891 0.7651
SJNB-17 GDSC1 6.1344 8.8783 3.318 3.2792
TGW GDSC1 6.1664 7.7098 3.8101 0.6136
KP-N-YN GDSC1 6.3359 8.4271 3.6066 1.3531
SK-N-BE(2)-M17 GDSC1 6.3616 8.0416 3.7659 0.6414
GOTO GDSC1 6.4232 14.8633 0.6832 18.58
KP-N-YS GDSC1 6.5329 8.8289 3.5365 1.4857
NH-12 GDSC1 6.6372 8.3587 3.7587 0.4972
SJNB-5 GDSC1 6.8342 8.319 3.8454 0.2027
SJNB-6 GDSC1 6.8375 8.5205 3.7768 0.3522
SJNB-13 GDSC1 6.8992 8.5286 3.7965 0.2826
SK-N-AS GDSC1 6.9423 8.3252 3.8808 0.1214
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 4.3895 9.6588 1.7096 19.3395
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFM-19 GDSC1 2.992 6.7566 1.8741 24.2992
CAL-148 GDSC1 3.2583 8.7916 1.1488 27.2211
Hs 578T GDSC1 3.7494 11.0556 0.4668 28.3129
HCC202 GDSC1 3.8152 5.9778 3.0413 12.0917
MRK-nu-1 GDSC1 3.9115 10.5414 0.8638 25.8643
COLO 824 GDSC1 4.016 8.6341 1.9059 19.5252
HCC38 GDSC1 4.159 7.9114 2.3896 15.624
HCC1187 GDSC1 4.1668 10.2027 1.2513 22.8646
UACC-812 GDSC1 4.2903 10.7452 1.0839 23.2917
HDQ-P1 GDSC1 4.3202 9.6372 1.6629 19.8873
BT-483 GDSC1 4.4197 7.2653 2.9308 10.591
HCC1428 GDSC1 4.4959 7.2529 2.9988 9.7989
DU4475 GDSC1 4.529 10.3106 1.4984 20.1069
EFM-192A GDSC1 4.5752 9.3605 2.0105 16.7243
BT-474 GDSC1 4.6036 11.0989 1.1653 21.716
MDA-MB-361 GDSC1 4.6369 8.9362 2.2717 14.7177
CAMA-1 GDSC1 4.639 8.1823 2.6492 11.972
AU565 GDSC1 4.7044 9.6147 1.9871 16.4259
MDA-MB-330 GDSC1 4.7282 10.6972 1.4662 19.5885
HCC1395 GDSC1 4.8264 11.0722 1.3574 19.8758
HCC1500 GDSC1 4.9657 9.5616 2.2173 13.9918
MDA-MB-453 GDSC1 5.0369 11.3073 1.4057 18.8922
HCC1419 GDSC1 5.0613 13.4414 0.3628 24.055
UACC-893 GDSC1 5.1856 9.8211 2.2547 13.0382
MDA-MB-415 GDSC1 5.2147 13.0221 0.6916 22.0618
MDA-MB-175-VII GDSC1 5.2205 7.9184 3.2062 6.017
HCC1937 GDSC1 5.2957 8.8556 2.8064 8.7734
HCC1569 GDSC1 5.3393 10.6873 1.9422 14.6504
ZR-75-30 GDSC1 5.4179 8.8614 2.8878 7.8439
CAL-120 GDSC1 5.45 11.4988 1.6248 16.2918
HCC2218 GDSC1 5.4548 13.2354 0.7705 20.9288
MDA-MB-157 GDSC1 5.5454 13.0367 0.9374 19.8184
MCF-7 GDSC1 5.6585 10.4514 2.2869 11.4318
CAL-85-1 GDSC1 5.6716 15.0084 0.0576 23.4688
OCUB-M GDSC1 5.8544 9.5762 2.8358 7.1181
MFM-223 GDSC1 6.1204 14.7856 0.5028 20.2525
MDA-MB-468 GDSC1 6.1712 14.1989 0.827 18.5623
HCC2157 GDSC1 6.2209 11.7447 2.0489 11.4968
BT-549 GDSC1 6.2379 15.1008 0.4339 20.2427
Evsa-T GDSC1 6.4057 8.283 3.6932 0.8935
YMB-1-E GDSC1 6.4472 12.5138 1.833 12.2643
MDA-MB-436 GDSC1 6.5723 15.5494 0.4552 19.2523
MDA-MB-231 GDSC1 6.6453 14.8022 0.869 17.0894
HCC70 GDSC1 6.711 20.2616 -1.755 26.8203
HCC1954 GDSC1 7.5374 17.5083 0.1777 18.1106
BT-20 GDSC1 7.617 16.1336 0.8846 14.6804
HCC1599 GDSC1 7.8505 15.647 1.2602 12.2722
CAL-51 GDSC1 8.1309 18.4033 0.1464 16.9246
T-47D GDSC1 8.2757 18.1491 0.3602 15.6947
HCC1806 GDSC1 8.6515 21.7174 -1.0859 20.4783
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DK-MG GDSC1 1.7779 12.6151 -2.0976 43.0427
YH-13 GDSC1 4.229 15.1421 -1.1658 32.1163
CAS-1 GDSC1 4.4597 12.0364 0.5789 25.1356
SNB-75 GDSC1 4.5854 10.0079 1.6954 18.7141
KINGS-1 GDSC1 4.6523 12.0574 0.726 23.7713
D-247MG GDSC1 4.7043 16.5689 -1.4859 31.4741
MOG-G-CCM GDSC1 4.7311 11.8753 0.8806 22.744
NMC-G1 GDSC1 4.8522 12.4391 0.6964 23.2272
KS-1 [Human Krukenberg tumour] GDSC1 4.8985 16.4579 -1.2725 30.3138
H4 GDSC1 5.3487 15.1043 -0.2393 25.5935
D-542MG GDSC1 5.3942 13.179 0.7522 21.2054
D-263MG GDSC1 5.4916 15.1282 -0.14 24.7868
SF268 GDSC1 5.7137 11.3622 1.8835 13.9162
D-423MG GDSC1 5.7758 8.9705 3.0686 5.6666
KALS-1 GDSC1 5.838 9.6229 2.8033 7.3849
LNZTA3WT4 GDSC1 5.8605 8.063 3.5245 2.4442
D-336MG GDSC1 5.9257 15.7965 -0.1398 23.5305
GI-1 GDSC1 6.0272 17.5383 -0.9245 26.0565
AM-38 GDSC1 6.0634 13.317 1.1802 17.0345
SF539 GDSC1 6.0747 11.2534 2.1857 10.9912
MOG-G-UVW GDSC1 6.1442 19.6164 -1.8648 28.5094
LN-229 GDSC1 6.1642 13.9989 0.9197 18.1164
SF295 GDSC1 6.3442 7.7523 3.8642 0.3343
SK-MG-1 GDSC1 6.3504 12.5021 1.7739 12.8678
PFSK-1 GDSC1 6.3869 12.8228 1.6449 13.542
Onda 10 GDSC1 6.4075 14.818 0.6941 18.5696
42-MG-BA GDSC1 6.4783 12.9672 1.6375 13.3514
T98G GDSC1 6.4847 8.5209 3.6357 1.0713
D-566MG GDSC1 6.5262 13.5598 1.3858 14.6671
D-502MG GDSC1 6.5706 9.8327 3.138 3.6699
U-118MG GDSC1 6.7269 16.3802 0.1606 20.151
M059J GDSC1 6.8492 15.1735 0.8305 16.7629
YKG-1 GDSC1 6.8667 12.9036 1.9211 10.7268
GaMG GDSC1 6.8747 17.8014 -0.4269 22.125
SW1783 GDSC1 6.9974 17.0197 0.0409 19.9755
U-87MG ATCC GDSC1 7.0126 21.5452 -2.1631 27.21
SF126 GDSC1 7.0171 8.6444 3.7989 0.2401
LN-405 GDSC1 7.1719 17.047 0.1495 19.0932
D-392MG GDSC1 7.1904 15.0845 1.1024 14.5593
Becker GDSC1 7.4573 23.6459 -2.8678 27.9503
ONS-76 GDSC1 7.6001 18.9401 -0.4683 20.5539
Hs 683 GDSC1 7.6023 17.4645 0.2425 17.6825
D283 Med GDSC1 7.7506 19.29 -0.5332 20.4549
LN-18 GDSC1 7.8043 17.2659 0.4712 16.2142
SW1088 GDSC1 7.9803 18.9386 -0.2083 18.7027
Onda 11 GDSC1 8.0815 17.7362 0.4295 15.7987
KNS-81-FD GDSC1 8.3773 22.1597 -1.4853 22.3219
U-251MG GDSC1 8.4859 19.988 -0.3719 18.2634
8-MG-BA GDSC1 8.9628 18.1701 0.7767 12.449
DBTRG-05MG GDSC1 9.1524 20.7577 -0.3036 16.6725
A-172 GDSC1 9.2889 19.8819 0.1886 14.4339
GB-1 GDSC1 9.3419 18.5158 0.8434 11.4541
KNS-42 GDSC1 9.831 21.5342 -0.2413 15.1777
Daoy GDSC1 10.8859 21.4614 0.4066 10.8486
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 5.0492 8.9057 2.6043 10.9779
TGBC24TKB GDSC1 6.7902 8.7294 3.6837 0.6532
TGBC1TKB GDSC1 7.6004 18.0249 -0.0273 18.8249
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 4.9235 8.7082 2.6077 11.3454
KLE GDSC1 5.3407 11.304 1.6393 16.5404
MFE-296 GDSC1 5.9352 9.3135 3.0081 5.7336
MFE-319 GDSC1 6.047 12.5314 1.5508 14.9998
AN3-CA GDSC1 6.4128 16.5855 -0.1666 22.3085
EN GDSC1 6.4934 8.4966 3.6488 1.007
MFE-280 GDSC1 7.5418 16.0887 0.8569 14.9854
ESS-1 GDSC1 7.6714 18.2248 -0.075 18.8573
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-13 GDSC1 4.1613 11.1167 0.7898 25.2509
VMRC-RCZ GDSC1 4.3032 8.4055 2.2645 15.9713
KTCTL-26A GDSC1 4.7574 14.8256 -0.5715 28.6091
UO-31 GDSC1 4.7622 11.1301 1.2774 20.5458
LB2241-RCC GDSC1 5.0179 12.3906 0.852 21.9184
SW13 GDSC1 5.1415 7.6851 3.2646 5.7888
KTCTL-195 GDSC1 5.2626 8.3507 3.0274 7.2333
LB996-RCC GDSC1 5.3194 11.7708 1.3926 18.0581
TK-10 GDSC1 5.5094 13.8217 0.5217 21.9407
SW156 GDSC1 5.5346 10.5804 2.1367 12.7923
KTCTL-21 GDSC1 5.5544 12.7524 1.0846 19.0263
LB1047-RCC GDSC1 5.5825 17.0402 -1.0196 27.581
BFTC-909 GDSC1 5.586 8.2599 3.2801 4.6018
VMRC-RCW GDSC1 5.5908 16.3706 -0.6804 26.4547
RXF 393L GDSC1 5.6109 11.5752 1.7054 15.3206
NCC021 GDSC1 5.8486 10.3906 2.4462 9.8357
KTCTL-1M GDSC1 5.8661 15.2932 0.064 22.8804
ACHN GDSC1 5.9178 15.7037 -0.0999 23.3955
A-498 GDSC1 5.9246 7.1642 3.9146 0.4002
A-704 GDSC1 6.0217 7.8555 3.6907 1.2793
HA7-RCC GDSC1 6.1402 16.8619 -0.5048 24.3128
BB65-RCC GDSC1 6.2113 17.5195 -0.776 25.0722
KTCTL-140 GDSC1 6.5529 15.4836 0.4734 19.22
OS-RC-2 GDSC1 6.8964 16.646 0.1513 19.7622
CAL-54 GDSC1 7.1982 17.3025 0.0442 19.4729
RCC10RGB GDSC1 7.6404 14.9545 1.4509 11.7038
Caki-1 GDSC1 7.7388 21.2417 -1.4872 23.6846
786-O GDSC1 7.8092 19.0929 -0.3982 19.8175
SN12C GDSC1 8.2231 19.678 -0.3988 18.9177
769-P GDSC1 8.3272 21.5763 -1.2385 21.6461
KMRC-1 GDSC1 8.8617 20.1263 -0.193 16.8075
KMRC-20 GDSC1 9.7856 23.163 -1.0275 18.1091
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1 3.7217 5.9321 2.9747 13.011
SNU-61 GDSC1 4.5486 8.7586 2.2896 14.9013
SW1417 GDSC1 4.7068 9.0921 2.2495 14.6323
NCI-H747 GDSC1 4.778 9.9464 1.8802 16.8711
HT115 GDSC1 4.9477 6.8677 3.5252 4.3455
COLO205 GDSC1 4.999 7.6269 3.1941 6.711
COLO 678 GDSC1 5.0562 8.0189 3.0439 7.6845
SNU-1040 GDSC1 5.1738 10.5796 1.8716 15.6199
LS1034 GDSC1 5.2398 7.5432 3.3969 4.561
SW1463 GDSC1 5.2925 7.4657 3.4665 3.934
T84 GDSC1 5.336 9.8909 2.3307 12.058
KM12 GDSC1 5.3475 11.9693 1.3156 18.4054
LS513 GDSC1 5.3722 8.6948 2.9368 7.6079
COLO 320HSR GDSC1 5.5303 8.3565 3.2007 5.2921
SW837 GDSC1 5.5906 10.9985 1.9728 13.7026
GP5d GDSC1 5.6492 11.3253 1.8553 14.2797
MDST8 GDSC1 5.8113 7.5715 3.7065 1.4501
LS411N GDSC1 5.8522 7.3478 3.8151 0.8541
SNU-407 GDSC1 5.9231 9.7558 2.7953 7.2375
LS180 GDSC1 5.9846 11.7509 1.8852 13.1502
SNU-C5 GDSC1 5.9853 10.3743 2.5444 8.8183
CW-2 GDSC1 6.0367 14.0143 0.8199 18.9724
NCI-H716 GDSC1 6.0503 12.5393 1.5493 14.9997
HT-55 GDSC1 6.0521 7.4287 3.8681 0.48
SW1116 GDSC1 6.1266 8.2929 3.5625 1.8323
SNU-175 GDSC1 6.136 15.2028 0.3093 21.0785
SNU-81 GDSC1 6.1765 7.6016 3.854 0.4517
CaR-1 GDSC1 6.2065 13.3921 1.2453 16.2872
HCT 116 GDSC1 6.2106 7.7721 3.8048 0.602
SW48 GDSC1 6.3014 13.0347 1.4845 14.6959
SW948 GDSC1 6.366 8.096 3.7473 0.7078
CL-11 GDSC1 6.4766 8.6223 3.5927 1.2746
HCT 15 GDSC1 6.4996 7.8024 3.9035 0.1859
C2BBe1 GDSC1 6.5964 8.8765 3.5462 1.3731
LoVo GDSC1 6.6057 18.4089 -0.9207 24.5411
SW626 GDSC1 6.611 13.6677 1.3916 14.419
RCM-1 [Human ESC] GDSC1 6.814 12.7451 1.9618 10.6017
LS123 GDSC1 6.8354 13.6794 1.5355 13.056
SNU-C1 GDSC1 6.8743 8.8483 3.6734 0.6369
HT-29 GDSC1 6.9082 15.3403 0.7907 16.8114
SNU-C2B GDSC1 7.0314 16.398 0.3656 18.4934
HCC2998 GDSC1 7.8452 16.7178 0.7567 14.797
RKO GDSC1 8.5054 17.253 0.9209 12.6425
SW620 GDSC1 9.0514 19.7002 0.1259 15.1442
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 7.0483 14.1388 1.4572 12.9901
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-475 GDSC1 3.9839 7.1477 2.6183 14.6248
JHH-4 GDSC1 4.4038 7.4772 2.8119 11.5616
JHH-2 GDSC1 4.4651 6.1529 3.5229 5.8019
SNU-423 GDSC1 4.6843 7.3963 3.0753 8.5773
JHH-6 GDSC1 4.8605 6.7936 3.5011 4.7634
Huh-7 GDSC1 4.9206 8.3248 2.7949 9.9663
Hep 3B2.1-7 GDSC1 4.9209 7.6474 3.1281 7.4404
HLE GDSC1 5.0426 7.4246 3.3223 5.6198
JHH-1 GDSC1 5.255 6.8445 3.7272 2.1991
HuH-1 GDSC1 5.3376 6.9139 3.7425 1.949
SNU-398 GDSC1 5.6498 7.3209 3.7311 1.5289
Hep-G2/C3A GDSC1 6.0351 7.5095 3.8312 0.6289
SNU-387 GDSC1 6.0641 8.1721 3.5819 1.8072
JHH-7 GDSC1 6.1197 7.9222 3.7087 1.0864
SK-HEP-1 GDSC1 6.1693 7.2802 3.965 0.1615
SNU-449 GDSC1 10.4382 26.6386 -2.2435 20.6937
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EBC-1 GDSC1 3.0258 18.6852 -3.9665 40.858
NCI-H2347 GDSC1 3.7123 9.8403 1.0395 25.8028
NCI-H211 GDSC1 3.7158 8.5506 1.6834 22.1742
COR-L88 GDSC1 3.8272 7.7838 2.1632 18.5601
NCI-H2291 GDSC1 3.928 12.9286 -0.3139 30.583
NCI-H1781 GDSC1 3.9377 8.1404 2.0838 18.652
SBC-5 GDSC1 4.064 11.9221 0.3048 27.7706
Lu-135 GDSC1 4.0641 9.2937 1.6181 21.1482
NCI-H2444 GDSC1 4.2013 10.0755 1.344 22.2166
NCI-H3255 GDSC1 4.288 9.0416 1.9338 18.2853
NCI-H2795 GDSC1 4.327 9.6785 1.6478 19.9543
NCI-H2810 GDSC1 4.3517 12.2462 0.3846 26.3791
HOP-62 GDSC1 4.4763 9.8717 1.6747 19.2365
NCI-H1915 GDSC1 4.4847 9.7877 1.7235 18.9032
UMC-11 GDSC1 4.5452 6.9715 3.1783 8.2342
NCI-H322M GDSC1 4.5643 7.1774 3.0909 8.8514
NCI-H727 GDSC1 4.5918 9.1623 2.1228 15.9075
NCI-H522 GDSC1 4.7897 12.1722 0.7795 23.0403
NCI-H1734 GDSC1 4.8244 9.0397 2.3676 13.4036
NCI-H513 GDSC1 4.8287 6.8606 3.4462 5.2721
NCI-H1648 GDSC1 4.8751 13.0276 0.421 24.4102
NCI-H2087 GDSC1 4.8891 9.0698 2.4026 12.9417
NCI-H1563 GDSC1 4.9034 11.1118 1.3985 19.3794
EPLC-272H GDSC1 4.9252 12.215 0.8662 22.1557
NCI-H1703 GDSC1 4.9529 6.7963 3.5629 4.0497
BEN GDSC1 4.9757 7.3694 3.3027 5.9522
COR-L95 GDSC1 4.9859 7.043 3.467 4.6819
LC-2/ad GDSC1 5.0068 12.7775 0.6505 22.9292
NCI-H1694 GDSC1 5.0258 7.2578 3.3911 5.1468
NCI-H1770 GDSC1 5.0343 8.2596 2.9106 8.7525
NCI-H2342 GDSC1 5.0934 12.1885 1.0116 20.8596
IST-SL1 GDSC1 5.1204 7.0018 3.5746 3.5519
LB647-SCLC GDSC1 5.1438 9.2879 2.4862 11.5415
PC-14 GDSC1 5.1641 9.1886 2.5498 11.0238
NCI-H520 GDSC1 5.1655 8.3161 2.9767 7.8783
NCI-H1355 GDSC1 5.1883 8.7667 2.7736 9.3201
CAL-12T GDSC1 5.3046 7.7322 3.3496 4.7501
NCI-H1623 GDSC1 5.3147 11.6778 1.435 17.8295
NCI-H2066 GDSC1 5.316 11.3947 1.5759 16.9983
NCI-H810 GDSC1 5.3351 9.7625 2.3929 11.6277
COLO 668 GDSC1 5.3378 10.4582 2.0537 13.9269
NCI-H1666 GDSC1 5.343 7.5822 3.4438 3.9822
NCI-H345 GDSC1 5.3569 6.9006 3.7587 1.8123
NCI-H1993 GDSC1 5.3646 15.7295 -0.5379 26.6245
NCI-H847 GDSC1 5.3725 11.4518 1.5901 16.7377
NCI-H2373 GDSC1 5.451 11.8586 1.4482 17.33
NCI-H1155 GDSC1 5.4522 8.4535 3.1051 6.1707
Lu-134-A GDSC1 5.4602 9.7929 2.4672 10.7456
NCI-H2141 GDSC1 5.4685 9.0673 2.8234 8.1779
NCI-H1651 GDSC1 5.4745 11.5872 1.5994 16.3691
Calu-3 GDSC1 5.4788 9.0944 2.8174 8.1936
NCI-H2135 GDSC1 5.4825 8.159 3.2628 4.958
NCI-H2803 GDSC1 5.4885 13.0267 0.8994 20.1847
SBC-3 GDSC1 5.4983 7.9046 3.3901 4.0197
COR-L23 GDSC1 5.5047 11.5442 1.6428 16.0169
SK-LU-1 GDSC1 5.5104 12.6194 1.1172 18.9868
NCI-H2595 GDSC1 5.5209 11.9334 1.4633 17.0298
NCI-H146 GDSC1 5.565 7.4473 3.6332 2.2539
NCI-H2029 GDSC1 5.5859 10.3678 2.2766 11.7052
NCI-H526 GDSC1 5.6155 7.5343 3.6226 2.2361
SBC-1 GDSC1 5.6253 8.5139 3.1869 5.1722
DMS 273 GDSC1 5.6368 10.7835 2.1105 12.6717
Lu-99A GDSC1 5.6375 12.0563 1.4888 16.5321
NCI-H226 GDSC1 5.6469 7.9099 3.4748 3.1391
NCI-H720 GDSC1 5.6503 10.5105 2.2526 11.6867
Lu-165 GDSC1 5.6671 11.4527 1.806 14.5362
NCI-H524 GDSC1 5.6764 8.1679 3.3761 3.7462
NCI-H1975 GDSC1 5.7059 12.1618 1.487 16.3409
NCI-H1876 GDSC1 5.7465 7.3224 3.7772 1.1526
HCC827 GDSC1 5.7631 8.57 3.2449 4.4673
NCI-H209 GDSC1 5.7953 8.2765 3.3956 3.3846
NCI-H3122 GDSC1 5.7957 11.2119 2.0144 12.8505
RERF-LC-Sq1 GDSC1 5.802 13.5665 0.8676 19.4075
NCI-H647 GDSC1 5.8419 11.1084 2.0967 12.1897
NCI-H661 GDSC1 5.8458 15.2069 0.0914 22.8257
NCI-H23 GDSC1 5.8888 13.0723 1.1739 17.5624
NCI-H2818 GDSC1 5.9012 13.8626 0.7952 19.4801
NCI-H2731 GDSC1 5.9415 13.2859 1.1076 17.7667
COR-L321 GDSC1 5.9442 11.2385 2.1044 11.8628
NCI-H2405 GDSC1 5.9506 12.1486 1.6688 14.5687
NCI-H2196 GDSC1 5.9712 8.8838 3.2247 4.1842
COR-L311 GDSC1 5.9761 8.292 3.487 2.4903
DMS 53 GDSC1 6.0014 8.2114 3.5343 2.1681
NCI-H1869 GDSC1 6.0149 12.2257 1.6766 14.3443
NCI-H1573 GDSC1 6.0258 7.8525 3.6938 1.2591
CPC-N GDSC1 6.0311 9.785 2.8493 6.6152
ABC-1 GDSC1 6.0334 12.8383 1.392 15.9495
SHP-77 GDSC1 6.0518 10.2634 2.6394 8.0077
NCI-H187 GDSC1 6.0519 12.6719 1.4861 15.3615
NCI-H1304 GDSC1 6.0561 7.708 3.7643 0.8921
NCI-H1836 GDSC1 6.0573 12.7088 1.4719 15.4283
NCI-H69 GDSC1 6.0607 11.8445 1.8926 12.899
COR-L303 GDSC1 6.0622 11.8788 1.8771 12.9915
EMC-BAC-1 GDSC1 6.0823 14.8954 0.4209 20.7313
NCI-H290 GDSC1 6.0932 8.5279 3.4472 2.5486
NCI-H1568 GDSC1 6.1083 10.8219 2.4129 9.4041
NCI-H196 GDSC1 6.1511 13.6449 1.083 17.309
NCI-H510A GDSC1 6.163 14.4048 0.7203 19.1078
IA-LM GDSC1 6.1639 7.5222 3.8779 0.3829
NCI-H1688 GDSC1 6.1904 17.6337 -0.8482 25.3705
NCI-H64 GDSC1 6.1936 7.4744 3.9062 0.2881
NCI-H841 GDSC1 6.1982 8.1443 3.6563 1.2569
HCC78 GDSC1 6.2084 15.9723 -0.0156 22.2524
NCI-H1755 GDSC1 6.2413 8.4232 3.5642 1.6774
NCI-H2869 GDSC1 6.2417 9.8247 2.958 5.4284
KNS-62 GDSC1 6.2452 8.1143 3.6891 1.0543
Lu-65 GDSC1 6.2594 12.9576 1.4927 14.7609
NCI-H2110 GDSC1 6.2624 11.6783 2.1081 11.0149
NCI-H838 GDSC1 6.2675 7.7077 3.851 0.4106
NCI-H2228 GDSC1 6.2757 12.1401 1.8968 12.3092
HCC44 GDSC1 6.2764 11.7517 2.0824 11.1433
EMC-BAC-2 GDSC1 6.2819 14.7628 0.6312 19.2087
NCI-H2023 GDSC1 6.3026 12.7724 1.6117 13.9563
NCI-H82 GDSC1 6.3428 12.6773 1.6848 13.42
NCI-H460 GDSC1 6.3472 7.7024 3.8829 0.2838
LXF 289 GDSC1 6.3879 14.3615 0.9023 17.5971
NCI-H441 GDSC1 6.4165 8.4327 3.6403 1.1138
NCI-H2171 GDSC1 6.4378 13.6991 1.2581 15.5996
NCI-H2122 GDSC1 6.4404 7.8838 3.8537 0.3202
NCI-H835 GDSC1 6.475 14.469 0.9114 17.3195
NCI-H2009 GDSC1 6.4751 13.7288 1.2695 15.4404
NCI-H2030 GDSC1 6.4825 13.3195 1.4715 14.298
IST-SL2 GDSC1 6.5309 8.8201 3.5391 1.4752
SW1271 GDSC1 6.5342 13.0482 1.6363 13.2175
LOU-NH91 GDSC1 6.5388 12.7572 1.7779 12.3684
NCI-H2804 GDSC1 6.5962 14.1203 1.1641 15.6944
A-427 GDSC1 6.6238 9.0003 3.5097 1.5195
NCI-H2722 GDSC1 6.6344 12.762 1.8385 11.7709
NCI-H2461 GDSC1 6.648 15.1955 0.6805 18.0039
NCI-H1436 GDSC1 6.6626 8.0472 3.8775 0.1896
RERF-LC-MS GDSC1 6.6721 30.3896 -6.8088 35.8511
NCI-H1092 GDSC1 6.7136 8.324 3.8 0.3441
HCC15 GDSC1 6.7739 11.214 2.6413 6.4295
NCI-H1581 GDSC1 6.7822 16.3889 0.1955 19.8605
NCI-H1793 GDSC1 6.7849 8.3149 3.8292 0.2496
NCI-H596 GDSC1 6.7964 8.2792 3.8456 0.2129
SK-MES-1 GDSC1 6.8328 8.8811 3.6447 0.7628
LK-2 GDSC1 6.8454 13.6957 1.5344 13.0383
SW1573 GDSC1 6.8679 14.0366 1.3874 13.806
NCI-H2081 GDSC1 6.9428 15.6729 0.6543 17.383
NCI-H2172 GDSC1 7.0004 8.3976 3.8765 0.1169
NCI-H1105 GDSC1 7.0101 17.5434 -0.2045 20.9371
NCI-H1048 GDSC1 7.0295 13.1638 1.9021 10.4731
EKVX GDSC1 7.0573 12.5494 2.2025 8.5988
NCI-H1944 GDSC1 7.1335 15.5497 0.843 16.0049
NCI-H1437 GDSC1 7.1589 8.8237 3.7878 0.2215
NCI-H446 GDSC1 7.2177 9.1638 3.6913 0.4132
NCI-H1792 GDSC1 7.2529 15.572 0.912 15.3794
LCLC-97TM1 GDSC1 7.2572 9.5328 3.5741 0.739
NCI-H358 GDSC1 7.2918 15.9643 0.751 16.0771
NCI-H1341 GDSC1 7.3386 16.8878 0.3406 17.865
COR-L105 GDSC1 7.354 16.3476 0.6096 16.6032
NCI-H1650 GDSC1 7.3586 15.7019 0.9201 15.0925
NCI-H1299 GDSC1 7.3855 9.3529 3.6868 0.3598
NCI-H2369 GDSC1 7.4484 16.3854 0.6546 16.172
DMS 114 GDSC1 7.6429 17.5835 0.2129 17.718
Calu-6 GDSC1 7.7109 16.7668 0.6465 15.614
NCI-H1838 GDSC1 7.7311 17.362 0.3774 16.7985
A-549 GDSC1 7.7692 13.7453 2.0785 7.9322
PaCa-3 GDSC1 7.8648 15.442 1.3638 11.6991
NCI-H1435 GDSC1 7.9301 18.2546 0.0845 17.6212
Lu-139 GDSC1 7.9715 19.4267 -0.448 19.6474
Ms-1 GDSC1 8.0302 21.2899 -1.3056 22.4887
NCI-H292 GDSC1 8.1896 18.0155 0.3677 15.8428
ChaGo-K-1 GDSC1 8.1984 16.874 0.9071 13.3251
HARA [Human squamous cell lung carcinoma] GDSC1 8.4271 18.1295 0.4659 14.9131
RERF-LC-KJ GDSC1 8.4718 17.5211 0.7767 13.3957
NCI-H2170 GDSC1 8.7529 19.0584 0.2377 15.2545
NCI-H650 GDSC1 8.921 22.4572 -1.2586 20.5094
NCI-H2591 GDSC1 9.1269 22.4528 -1.1197 19.6517
LCLC-103H GDSC1 9.3351 19.2305 0.5153 12.9453
HCC33 GDSC1 9.526 22.0454 -0.6692 17.3315
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 6.4616 12.9233 1.6472 13.337
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 4.0082 7.2425 2.5926 14.7201
TE-8 GDSC1 4.3047 11.8084 0.5643 25.7623
KYSE-520 GDSC1 4.7157 9.7518 1.9278 16.7767
OE19 GDSC1 4.8933 8.5381 2.6691 10.9891
OE33 GDSC1 5.0266 23.2177 -4.5453 36.4073
TE-5 GDSC1 5.0472 7.7981 3.1449 6.9478
KYSE-70 GDSC1 5.1252 10.4239 1.9118 15.5171
TE-4 GDSC1 5.1898 10.9027 1.7239 16.4984
KYSE-140 GDSC1 5.4425 9.4706 2.6111 9.7764
KYSE-510 GDSC1 5.464 9.9497 2.3937 11.2481
TE-10 GDSC1 5.4696 13.711 0.5462 21.9492
COLO 680N GDSC1 5.5346 11.7974 1.5404 16.5379
KYSE-410 GDSC1 5.566 9.0066 2.9176 7.2439
TE-11 GDSC1 5.6545 9.4522 2.7643 8.1164
TE-6 GDSC1 5.6801 16.3403 -0.5963 25.9117
KYSE-270 GDSC1 5.7036 11.8051 1.66 15.324
T.T GDSC1 5.7454 10.2584 2.4398 10.1513
OE21 GDSC1 5.7862 11.2149 2.0063 12.929
EC-GI-10 GDSC1 5.9467 9.59 2.8874 6.5436
KYSE-150 GDSC1 6.0298 10.7593 2.3911 9.7456
TE-1 GDSC1 6.133 9.4658 3.0565 4.9893
TE-9 GDSC1 6.3049 11.6255 2.161 10.5703
KYSE-450 GDSC1 6.6657 11.4184 2.4845 7.6552
KYSE-180 GDSC1 10.3317 22.9401 -0.5832 15.5871
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-3 GDSC1 3.999 11.7109 0.355 27.8087
Caov-4 GDSC1 4.7397 8.4326 2.6036 11.9728
EFO-21 GDSC1 4.8075 9.8886 1.9322 16.4327
Caov-3 GDSC1 4.933 7.557 3.1811 7.0005
FU-OV-1 GDSC1 5.2489 10.4473 1.9933 14.5971
OVCAR-5 GDSC1 5.2671 11.9432 1.2675 18.9268
JHOS-2 GDSC1 5.2825 11.263 1.6158 16.8642
A2780 GDSC1 5.4124 10.8568 1.9128 14.6169
RMG-I GDSC1 5.421 8.3234 3.1462 5.9488
DOV13 GDSC1 5.4911 11.862 1.4764 17.0441
ES-2 GDSC1 5.527 7.4401 3.6156 2.4332
SK-OV-3 GDSC1 5.5431 14.3722 0.2747 22.9382
OAW28 GDSC1 5.5815 13.5373 0.7172 20.8023
OC 314 GDSC1 5.6002 8.4871 3.1838 5.2516
OVK18 GDSC1 5.7664 7.673 3.642 1.8799
OVCAR-4 GDSC1 5.9005 10.8434 2.2645 10.9263
OAW42 GDSC1 5.9125 6.9004 4.0038 0.1611
JHOS-4 GDSC1 5.9827 10.1098 2.6674 7.981
OV56 GDSC1 6.0703 16.8541 -0.5534 24.6766
OVKATE GDSC1 6.2775 11.4217 2.2395 10.1307
TOV-21G GDSC1 6.3437 7.4488 3.9688 0.1119
OV-90 GDSC1 6.5002 17.319 -0.4627 23.2072
EFO-27 GDSC1 6.549 13.8321 1.2705 15.2433
IGROV-1 GDSC1 6.9802 14.9171 1.0424 15.3715
Kuramochi GDSC1 7.0261 17.5708 -0.2065 20.9057
TOV-112D GDSC1 7.4306 21.4509 -1.8103 25.3133
OVTOKO GDSC1 7.439 17.7867 -0.0231 19.1807
OVISE GDSC1 7.9908 15.9967 1.1851 12.3676
OVCAR-8 GDSC1 10.0013 19.848 0.6253 11.3122
TYK-nu GDSC1 10.2289 25.9627 -2.0604 20.5369
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 0.8204 9.1542 -1.3974 46.9916
SU.86.86 GDSC1 3.2353 6.0437 2.4458 19.1961
HuP-T3 GDSC1 4.2178 10.97 0.9107 24.4476
Capan-1 GDSC1 4.5261 7.4043 2.9474 10.092
Capan-2 GDSC1 4.768 7.6198 3.0284 8.6715
CFPAC-1 GDSC1 5.0127 6.8854 3.5601 3.9186
BxPC-3 GDSC1 5.228 8.9672 2.7043 9.7139
Hs 766T GDSC1 5.2626 9.7966 2.3235 12.3272
Panc 08.13 GDSC1 5.3981 10.8162 1.9222 14.6001
Panc 03.27 GDSC1 5.6146 9.7263 2.6064 9.3402
Panc 02.03 GDSC1 5.6406 10.4272 2.2862 11.4868
HuP-T4 GDSC1 5.6549 12.6817 1.1942 18.1366
PL4 GDSC1 5.732 10.9422 2.1006 12.4684
Panc 04.03 GDSC1 5.8071 12.0415 1.6189 15.2717
YAPC GDSC1 5.8617 10.6139 2.3482 10.4673
MIA PaCa-2 GDSC1 5.9529 10.3329 2.5428 8.9092
PaTu 8988t GDSC1 6.0273 11.0737 2.2397 10.759
Panc 10.05 GDSC1 6.1405 12.3447 1.7064 13.8244
HPAC GDSC1 6.2314 13.5878 1.1677 16.6389
DAN-G GDSC1 6.3212 10.7222 2.5948 7.6863
QGP-1 GDSC1 6.3281 7.7433 3.8614 0.3496
SUIT-2 GDSC1 6.7186 14.9425 0.852 16.986
KP-3 GDSC1 6.912 14.4751 1.2078 14.6718
HPAF-II GDSC1 6.9295 13.7964 1.5417 12.796
AsPC-1 GDSC1 7.0285 17.2363 -0.0423 20.2418
KP-1N GDSC1 7.1597 9.4556 3.5636 0.8363
MZ-PC-1 GDSC1 7.1742 15.8652 0.7195 16.508
SW1990 GDSC1 7.2067 14.0611 1.5952 11.8542
PSN1 GDSC1 7.2203 9.1047 3.713 0.3591
PaTu 8902 GDSC1 9.5016 21.8467 -0.5917 17.0952
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 4.4555 8.996 2.0952 16.584
NCI-H28 GDSC1 4.9717 10.6793 1.6672 17.5567
MSTO-211H GDSC1 6.079 14.5133 0.6061 19.8872
IST-Mes1 GDSC1 6.9902 18.0366 -0.4589 21.9599
NCI-H2452 GDSC1 7.0684 18.079 -0.4238 21.6383
MPP 89 GDSC1 7.3445 17.6982 -0.0456 19.4944
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 5.5879 11.1668 1.8886 14.2487
PC-3 GDSC1 6.083 13.3413 1.1824 16.968
VCaP GDSC1 6.2339 7.9192 3.7592 0.7616
22Rv1 GDSC1 6.4649 13.9109 1.1746 15.979
LNCaP clone FGC GDSC1 6.6605 14.5549 0.9989 16.3929
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.6568 8.4067 3.749 0.517
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MMAc-SF GDSC1 4.2752 8.9858 1.9509 18.2212
WM115 GDSC1 4.5091 7.2034 3.0341 9.4799
SK-MEL-28 GDSC1 4.5781 7.5157 2.9332 10.0247
COLO 792 GDSC1 4.6371 7.4494 3.0124 9.217
Hs 940.T GDSC1 4.6425 6.105 3.6814 4.0019
Hs 938.T GDSC1 4.692 5.8607 3.8348 2.69
SK-MEL-2 GDSC1 4.7457 10.6027 1.5273 19.1682
SK-MEL-30 GDSC1 4.893 6.3052 3.7562 2.7677
CP50-MEL-B GDSC1 4.929 7.7294 3.0938 7.678
RPMI-7951 GDSC1 4.962 9.686 2.1529 14.4455
SK-MEL-5 GDSC1 4.9906 7.2722 3.36 5.4766
Mel Ho GDSC1 5.0099 9.1709 2.4442 12.2569
HMV-II GDSC1 5.023 7.1796 3.4267 4.8874
A-375 GDSC1 5.0263 7.2704 3.3854 5.1891
Mel JuSo GDSC1 5.0787 11.0639 1.5589 17.8586
COLO 800 GDSC1 5.0792 8.1282 3.007 7.8965
IGR-1 GDSC1 5.1596 8.7916 2.7409 9.6444
IPC-298 GDSC1 5.1928 7.9596 3.1677 6.3764
CP66-MEL GDSC1 5.2245 8.1555 3.0952 6.8319
GAK GDSC1 5.3055 6.8926 3.7342 2.0594
RVH-421 GDSC1 5.3772 8.8828 2.8498 8.2308
M14 GDSC1 5.4551 7.3513 3.6149 2.5696
A101D GDSC1 5.4929 8.9775 2.8828 7.6828
LB2518-MEL GDSC1 5.5329 9.5944 2.6139 9.5074
IST-MEL1 GDSC1 5.5477 7.6353 3.5409 2.8866
451Lu GDSC1 5.5922 8.1454 3.3364 4.1935
COLO 829 GDSC1 5.6084 10.5276 2.2148 12.0586
SK-MEL-1 GDSC1 5.6334 7.1834 3.78 1.2768
WM278 GDSC1 5.648 10.4603 2.2753 11.5395
A2058 GDSC1 5.7064 6.7291 3.9875 0.2899
COLO 783 GDSC1 5.7094 13.4542 0.8542 19.7469
MeWo GDSC1 5.8087 7.2085 3.8502 0.7368
HT-144 GDSC1 5.8476 13.4201 0.9732 18.7384
UACC-257 GDSC1 5.8975 9.165 3.0534 5.5027
SK-MEL-24 GDSC1 5.9073 10.1759 2.5873 8.7174
WM793 GDSC1 5.9546 7.8806 3.6488 1.5814
DJM-1 GDSC1 5.997 8.6125 3.3594 3.2542
SK-MEL-3 GDSC1 6.0692 13.7394 0.978 18.0828
WT2-iPS GDSC1 6.0889 7.3189 3.9221 0.2917
MZ-MEL-2 GDSC1 6.1361 12.6459 1.5577 14.716
COLO 679 GDSC1 6.2076 13.542 1.1732 16.6741
WM1552C GDSC1 6.2914 12.7556 1.6121 13.9832
UACC-62 GDSC1 6.2994 7.4519 3.9524 0.1494
MZ-MEL-7 GDSC1 6.3022 7.6727 3.8767 0.3192
VMRC-MELG GDSC1 6.3445 14.715 0.6993 18.7135
G-mel GDSC1 6.4611 8.0116 3.816 0.4156
IGR-37 GDSC1 6.4857 7.5709 3.9765 0.0768
A-431 GDSC1 6.6498 18.3718 -0.87 24.2606
SH-4 GDSC1 6.7059 8.2953 3.8073 0.3289
CHL-1 GDSC1 6.8612 8.5784 3.7652 0.372
WM35 GDSC1 6.9468 8.861 3.6969 0.5224
G-361 GDSC1 6.9837 14.2162 1.3784 13.5773
A-388 GDSC1 7.0054 16.3378 0.3767 18.5076
LOX-IMVI GDSC1 7.4772 15.9669 0.8724 15.0563
LB373-MEL-D GDSC1 7.9016 19.8174 -0.6836 20.6673
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 5.7108 7.3886 3.7331 1.4348
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-402 GDSC1 4.1187 7.8316 2.3949 15.7415
Hs 633.T GDSC1 4.5777 9.6333 1.8763 17.5972
SW982 GDSC1 4.9034 12.7274 0.5934 23.5378
A-204 GDSC1 4.9392 12.5855 0.6926 22.9541
SW684 GDSC1 5.2449 11.8146 1.3143 18.7371
EW-8 GDSC1 5.2461 7.2283 3.5477 3.4583
Rh41 GDSC1 5.4451 14.4222 0.1746 23.6594
MES-SA GDSC1 5.5021 10.9051 1.9546 14.08
KYM-1 GDSC1 5.7585 19.0992 -1.9063 29.6058
VA-ES-BJ GDSC1 5.7585 7.492 3.7137 1.4797
RKN GDSC1 6.1377 7.4029 3.9106 0.3011
G-401 GDSC1 6.1901 18.5966 -1.3246 26.8751
SK-UT-1 GDSC1 6.2909 8.4952 3.5584 1.6479
MFH-ino GDSC1 6.6039 14.4975 0.9875 16.5967
Rh30 GDSC1 6.7091 15.1916 0.7251 17.6322
HT-1080 GDSC1 7.1934 14.519 1.3718 13.1218
SW872 GDSC1 7.5587 15.98 0.9193 14.6401
GCT GDSC1 7.9413 18.8988 -0.2155 18.8168
Rh18 GDSC1 8.2261 18.8351 0.0042 17.3152
SK-LMS-1 GDSC1 8.7156 22.2598 -1.3023 21.058
RD GDSC1 10.2776 24.7642 -1.4645 18.6655
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-5 GDSC1 -2.0572 38.3258 -18.2506 53.2191
Hs 746.T GDSC1 -1.7312 72.1787 -34.7741 51.5236
MKN45 GDSC1 -0.1328 14.2581 -4.7153 51.683
IM95 GDSC1 2.9699 17.8793 -3.614 40.6259
HSC-39 GDSC1 3.3638 7.5836 1.837 22.7623
GCIY GDSC1 3.8549 8.4455 1.8591 20.4839
TGBC11TKB GDSC1 4.4025 9.5406 1.7794 18.8537
AGS GDSC1 4.7781 6.5327 3.5697 4.4697
NUGC-4 GDSC1 5.2848 9.0335 2.7124 9.4913
KATO III GDSC1 5.3819 11.6665 1.4913 17.2929
SNU-1 GDSC1 5.3957 7.5374 3.4964 3.495
MKN7 GDSC1 5.987 11.7351 1.8945 13.0855
HGC-27 GDSC1 6.0223 7.7893 3.7174 1.1455
MKN1 GDSC1 6.0444 13.2474 1.2005 16.9779
MKN28 GDSC1 6.3008 10.2141 2.816 6.2537
SCH GDSC1 6.3604 7.6561 3.904 0.2288
ECC10 GDSC1 6.4902 8.1527 3.7762 0.5238
SNU-16 GDSC1 6.5485 7.9275 3.878 0.2226
Fu97 GDSC1 6.6059 12.5794 1.9062 11.4295
OCUM-1 GDSC1 6.6502 8.4595 3.7272 0.5915
NCI-N87 GDSC1 6.7299 8.6024 3.7063 0.6134
23132/87 GDSC1 6.8727 8.4553 3.8123 0.2571
NUGC-3 GDSC1 7.0374 8.4492 3.8719 0.1165
RERF-GC-1B GDSC1 7.1014 9.7869 3.4134 1.4939
RF-48 GDSC1 7.5986 9.2191 3.8064 0.1078
SNG-M GDSC1 5.5203 8.0713 3.3269 4.4169
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 4.2684 16.0613 -1.5924 33.0861
TT2609-C02 GDSC1 4.5298 7.494 2.9056 10.4016
IHH-4 GDSC1 4.7682 7.3479 3.1628 7.6363
FTC-133 GDSC1 5.0465 6.6303 3.7012 2.8096
K5 GDSC1 5.0504 6.732 3.6563 3.1232
CAL-62 GDSC1 5.1979 6.8174 3.7066 2.45
CGTH-W-1 GDSC1 5.351 8.341 3.0918 6.5246
8505C GDSC1 5.6326 7.9484 3.4494 3.3362
KMH-2 GDSC1 5.6765 8.3205 3.3069 4.2203
WRO GDSC1 5.9744 7.7918 3.6944 1.3147
ML-1 [Human leukemia] GDSC1 5.9792 14.8913 0.3468 21.3521
ASH-3 GDSC1 6.1679 7.4498 3.9053 0.3018
8305C GDSC1 6.3154 14.9026 0.5869 19.3269
B-CPAP GDSC1 6.3234 13.8096 1.1249 16.6188
BHT-101 GDSC1 6.3324 15.1325 0.4868 19.7449
TT GDSC1 6.5567 8.0465 3.8395 0.3081
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 GDSC1 4.2739 8.0235 2.4309 14.8875
OSC-20 GDSC1 4.8294 7.106 3.3268 6.1866
SCC-25 GDSC1 4.842 10.2456 1.7816 17.2819
SCC-15 GDSC1 4.9167 6.566 3.6484 3.5043
PE/CA-PJ15 GDSC1 4.9998 8.0201 3.0029 8.159
BHY GDSC1 5.1412 7.6175 3.2968 5.5496
CAL-27 GDSC1 5.1727 8.1969 3.0395 7.3891
JHU-011 GDSC1 5.3163 8.0973 3.1848 5.9288
JHU-022 GDSC1 5.34 10.8363 1.8694 15.115
SAT [Human HNSCC] GDSC1 5.352 10.1389 2.2208 12.7642
DOK GDSC1 5.3952 13.1504 0.7672 21.1295
BB30-HNC GDSC1 5.4874 7.3955 3.6133 2.52
NCI-H3118 GDSC1 5.5677 9.8285 2.525 10.0403
LB771-HNC GDSC1 5.7942 8.6943 3.2067 4.6651
HO-1-N-1 GDSC1 5.9119 7.354 3.8385 0.6972
HSC-3 GDSC1 6.0767 7.5869 3.8192 0.6442
OSC-19 GDSC1 6.0986 7.7811 3.7544 0.897
HSC-2 GDSC1 6.138 7.4368 3.8987 0.3345
PCI-06A GDSC1 6.2188 14.954 0.4919 20.0306
BICR 10 GDSC1 6.2845 7.8343 3.8115 0.5294
SAS GDSC1 6.2855 8.2559 3.6515 1.1893
BICR 22 GDSC1 6.2916 7.6355 3.8859 0.2994
FaDu GDSC1 6.3303 7.5608 3.9261 0.1913
PCI-15A GDSC1 6.3422 13.511 1.2827 15.718
Detroit 562 GDSC1 6.396 8.2237 3.7117 0.8254
HO-1-u-1 GDSC1 6.514 8.1717 3.7786 0.5024
KOSC-2 GDSC1 6.6809 16.1347 0.2473 19.8956
SKN-3 GDSC1 6.7274 8.756 3.6485 0.8225
SCC-4 GDSC1 6.8028 8.489 3.775 0.3712
KON GDSC1 6.8234 8.3694 3.8242 0.2478
PCI-38 GDSC1 6.8295 8.4405 3.8018 0.295
PCI-30 GDSC1 6.8626 8.902 3.649 0.7278
BICR 78 GDSC1 6.8633 8.8633 3.6635 0.6767
BB49-HNC GDSC1 6.9403 9.2138 3.5643 0.9905
Ca9-22 GDSC1 6.9702 8.7879 3.7318 0.4127
HSC-4 GDSC1 7.0818 8.4322 3.8925 0.0857
PCI-04B GDSC1 7.2582 19.0577 -0.7654 22.422
CAL-33 GDSC1 7.7394 9.4999 3.7609 0.1397
BICR 31 GDSC1 8.2256 18.7074 0.0644 17.067
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1 4.2017 8.5619 2.101 17.4926
CAL-29 GDSC1 5.0658 9.1178 2.5122 11.5943
SW780 GDSC1 5.6783 8.5271 3.2134 4.8676
HT-1376 GDSC1 5.7411 11.3584 1.9048 13.7036
5637 GDSC1 5.8451 11.5905 1.8655 13.6578
HT-1197 GDSC1 5.9436 10.146 2.625 8.3676
RT-112 GDSC1 5.9604 13.5723 0.981 18.3744
BFTC-905 GDSC1 6.0091 7.4743 3.8337 0.6388
UM-UC-3 GDSC1 6.0946 10.128 2.7297 7.2909
SW1710 GDSC1 6.1356 10.9068 2.3905 9.4858
KU-19-19 GDSC1 6.1462 7.5947 3.8446 0.5022
647V GDSC1 6.3521 10.4159 2.7546 6.5544
J82 GDSC1 6.5718 12.8492 1.756 12.4172
T24 GDSC1 6.7932 13.4527 1.6153 12.7014
639V GDSC1 7.0606 15.3668 0.8814 15.9905
TCCSUP GDSC1 7.3336 15.3866 1.0532 14.479
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ME-180 GDSC1 3.537 9.6096 0.9985 26.7494
SKN GDSC1 4.5871 9.0005 2.1998 15.394
HT-3 GDSC1 4.8128 10.6344 1.5649 18.7132
JHOS-3 GDSC1 4.8697 9.4378 2.205 14.3922
OV17R GDSC1 4.9015 8.4362 2.7256 10.5438
OVCA433 GDSC1 4.9633 8.6169 2.6827 10.6684
OVMIU GDSC1 5.0119 7.8872 3.0765 7.5661
SiHa GDSC1 5.0746 6.6267 3.72 2.6139
OVCA420 GDSC1 5.1392 8.9662 2.6406 10.4399
ACC-OV7 GDSC1 5.1573 9.1287 2.5742 10.8675
HEC-1 GDSC1 5.221 8.2726 3.0364 7.2798
SW962 GDSC1 5.3499 11.4551 1.5717 16.9179
Ca Ski GDSC1 5.4024 11.5028 1.5874 16.6619
NEC8 GDSC1 5.4139 11.4495 1.6222 16.4177
HEY GDSC1 5.5017 15.4383 -0.2863 25.3124
SiSo GDSC1 5.6601 8.1125 3.3915 3.6737
PEO1 GDSC1 5.6996 13.7821 0.6852 20.6036
LB831-BLC GDSC1 5.7533 10.3953 2.3795 10.5436
SKG-IIIa GDSC1 5.9058 7.8516 3.637 1.7111
NCC-IT GDSC1 5.9749 7.9772 3.6189 1.7197
MS751 GDSC1 6.0053 8.0118 3.6194 1.6769
SW756 GDSC1 6.0188 7.591 3.7933 0.7981
HeLa GDSC1 6.0551 7.2323 3.9401 0.2586
DSH1 GDSC1 6.135 13.4751 1.1542 16.9754
TC-YIK GDSC1 6.1395 12.075 1.8356 13.0415
DoTc2 4510 GDSC1 6.1948 8.0373 3.6969 1.0669
OMC-1 [Human cervical carcinoma] GDSC1 6.2779 8.2237 3.6608 1.1534
KGN GDSC1 6.2862 13.7825 1.1119 16.7876
PA-1 GDSC1 6.3173 7.8829 3.8067 0.5255
SW954 GDSC1 6.4126 13.6777 1.251 15.7046
C-33 A GDSC1 6.4291 8.3346 3.6834 0.9148
NT2-D1 GDSC1 6.468 11.9365 2.1201 10.4342
PWR-1E GDSC1 6.6682 12.8764 1.8064 11.8818
UWB1.289 GDSC1 6.7044 14.1746 1.2119 15.1646
CAL-39 GDSC1 6.7109 13.9111 1.3424 14.4402
JAR GDSC1 6.7193 8.1944 3.8472 0.2329
JEG-3 GDSC1 6.9607 8.528 3.8187 0.2179
BPH-1 GDSC1 7.1477 20.233 -1.4192 24.8129
C-4-I GDSC1 7.1726 16.8997 0.2211 18.7845
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT00651365) A Safety and Dose-finding Study of JNJ-38877605 in Patients With Advanced or Refractory Solid Tumors.. U.S. National Institutes of Health.
2 The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation. Clin Cancer Res. 2015 May 15;21(10):2297-304.