Details of the Drug

General Information of Drug (ID: DMELUAK)

Drug Name
MP470
Synonyms
Amuvatinib; 850879-09-3; MP-470; MP470; MP 470; Amuvatinib (MP-470); HPK56; UNII-SO9S6QZB4R; Amuvatinib(MP470); N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; SO9S6QZB4R; HPK-56; HPK 56; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro-[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide; Amuvatinib [USAN:INN]; Amuvatinib (MP-470, HPK 56); PubChem22479; Amuvatinib (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 447.5
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption
The drug is orally available []
Chemical Identifiers
Formula
C23H21N5O3S
IUPAC Name
N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide
Canonical SMILES
C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6
InChI
InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)
InChIKey
FOFDIMHVKGYHRU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11282283
ChEBI ID
CHEBI:91389
CAS Number
850879-09-3
UNII
SO9S6QZB4R
DrugBank ID
DB12742
TTD ID
D0T1GF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet-derived growth factor receptor alpha (PDGFRA) TT8FYO9 PGFRA_HUMAN Modulator [2]
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase Kit (KIT) DTT KIT 2.06E-01 -0.1 -0.14
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 0.6602 8.547 -1.2887 47.8619
EW-7 GDSC1 0.5534 3.6621 0.3688 47.431
CAL-72 GDSC1 1.2142 6.131 0.3087 42.0964
SK-ES-1 GDSC1 1.321 5.8123 0.5464 40.6851
HuO9 GDSC1 1.3786 6.0458 0.5169 40.3712
NOS-1 [Human HNSCC] GDSC1 1.714 7.6362 0.1903 39.176
EW-24 GDSC1 3.081 8.169 1.2866 27.3245
TC-71 GDSC1 3.2336 12.0142 -0.465 33.7322
CHSA0108 GDSC1 3.7609 5.475 3.2302 10.8823
ES7 GDSC1 3.8683 10.7425 0.7262 26.6881
CADO-ES1 GDSC1 3.9141 4.8844 3.656 6.9432
EW-3 GDSC1 3.9934 4.9214 3.7182 6.1024
EW-1 GDSC1 4.1607 8.4538 2.1201 17.5195
MHH-ES-1 GDSC1 4.3633 6.2473 3.3935 7.1726
ES8 GDSC1 4.8719 6.7107 3.549 4.3682
EW-18 GDSC1 5.107 7.2365 3.4555 4.4565
ES1 GDSC1 5.4642 11.751 1.511 16.9241
ES5 GDSC1 5.5751 12.7864 1.0833 18.9704
ES4 GDSC1 5.647 11.528 1.7546 14.9124
EW-13 GDSC1 5.6506 13.3197 0.8766 19.8096
H-EMC-SS GDSC1 5.7051 12.7249 1.21 17.9016
EW-11 GDSC1 5.7929 8.5418 3.2752 4.1978
U2OS GDSC1 5.815 10.6521 2.2982 10.9288
CAL-78 GDSC1 5.8694 11.7434 1.8084 13.9448
CHSA8926 GDSC1 5.8723 8.9261 3.1476 4.9072
SK-PN-DW GDSC1 6.0235 20.7838 -2.5376 30.4538
ES6 GDSC1 6.2006 16.0499 -0.0595 22.4513
MG-63 GDSC1 6.3053 7.7079 3.8653 0.3492
SaOS-2 GDSC1 6.6775 8.2035 3.8289 0.2873
HuO-3N1 GDSC1 6.6894 8.9541 3.5569 1.234
HOS GDSC1 6.8052 8.0872 3.9134 0.1027
G-292 clone A141B1 GDSC1 6.9268 8.7047 3.745 0.3966
EW-16 GDSC1 7.073 13.6793 1.689 11.6224
A-673 GDSC1 7.236 18.1277 -0.329 20.875
SJSA-1 GDSC1 7.3121 17.4705 0.042 19.2103
CHSA0011 GDSC1 7.5326 11.2434 3.0297 2.9117
NY GDSC1 7.8974 20.6015 -1.0651 21.9947
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 0.5487 1.5129 0.5485 47.1662
A3/Kawakami GDSC1 -3.6891 1.2905 -3.8176 81.2471
BL-41 GDSC1 -2.932 4.5219 -3.65 70.4127
Ku812 GDSC1 -2.3494 -1.3376 -2.3494 83.079
SU-DHL-16 GDSC1 -1.8993 -0.3765 -1.8995 77.1259
BC-1 GDSC1 -1.7818 1.002 -1.8022 73.2252
L-363 GDSC1 -0.3506 3.2302 -0.5262 57.0474
MY-M12 GDSC1 -0.2376 120.6238 -57.6709 50.2542
CTB-1 GDSC1 -0.1233 3.1553 -0.2678 54.8431
EoL-1 GDSC1 0.0934 7.5671 -1.4559 51.5094
WIL2 NS GDSC1 0.27 17.8713 -6.068 50.1587
MOLP-8 GDSC1 0.3188 6.6206 -0.8351 50.0233
Kasumi-1 GDSC1 0.3358 11.0776 -2.7633 49.933
SU-DHL-5 GDSC1 0.6676 3.205 0.5739 45.9454
QIMR-WIL GDSC1 0.7239 6.8746 -0.5086 46.9211
697 GDSC1 0.7595 4.6637 0.3357 45.5803
OCI-Ly19 GDSC1 0.7603 4.1572 0.4787 45.2958
VAL GDSC1 1.0079 6.7541 -0.1604 44.4974
DEL GDSC1 1.0644 7.3368 -0.3459 44.4071
OCI-AML-2 GDSC1 1.0953 7.6019 -0.4281 44.3321
SU-DHL-10 GDSC1 1.4116 3.8041 1.2707 37.1615
GR-ST GDSC1 1.4829 7.8044 -0.1198 41.3487
NALM-6 GDSC1 1.5575 6.0202 0.7167 38.4917
MOLM-13 GDSC1 1.7353 7.2127 0.3999 38.4193
Daudi GDSC1 1.7745 4.777 1.4054 33.9922
LP-1 GDSC1 1.8392 8.1959 0.0627 38.8077
KG-1 GDSC1 2.1287 8.026 0.4295 36.0389
SUP-B15 GDSC1 2.2155 9.3782 -0.1215 37.3122
MOLT-13 GDSC1 2.2585 4.4162 2.0436 27.1807
SU-DHL-4 GDSC1 2.6281 6.901 1.4454 28.7405
P30/OHK GDSC1 2.6864 11.1836 -0.5518 36.2762
ALL-PO GDSC1 2.9146 8.818 0.8152 30.4435
MV4-11 GDSC1 2.931 10.1507 0.1803 32.918
SUP-M2 GDSC1 2.9368 9.1891 0.6557 31.0354
EJM GDSC1 2.9597 6.7372 1.8512 24.6065
HAL-01 GDSC1 2.9683 6.1002 2.1514 22.5803
THP-1 GDSC1 3.0312 8.8221 0.9227 29.393
SK-MM-2 GDSC1 3.0413 7.5202 1.5611 25.9763
Sc-1 GDSC1 3.2134 8.6512 1.176 27.2866
MOLT-16 GDSC1 3.3154 11.631 -0.2019 32.5765
JSC-1 GDSC1 3.5318 9.4412 1.0773 26.3742
DND-41 GDSC1 3.5449 6.5732 2.4975 17.383
NU-DUL-1 GDSC1 3.5518 4.4516 3.4428 10.3534
AMO1 GDSC1 3.6561 9.1212 1.3471 24.4017
Farage GDSC1 3.6576 9.0867 1.3656 24.2917
Karpas-620 GDSC1 3.6828 8.1143 1.8699 21.137
RPMI-8402 GDSC1 3.686 10.3494 0.7631 27.2545
Mono-Mac-6 GDSC1 3.7441 10.4861 0.746 27.0964
BV-173 GDSC1 3.7578 8.2659 1.8621 20.8689
SU-DHL-6 GDSC1 3.762 4.5675 3.6298 7.8997
OCI-M1 GDSC1 3.786 7.738 2.149 18.8304
MC116 GDSC1 3.7935 4.1322 3.7839 6.6662
GDM-1 GDSC1 3.7976 4.8497 3.5523 8.2813
SIG-M5 GDSC1 3.8118 4.1639 3.799 6.4583
Hs 445 GDSC1 3.8155 4.4462 3.7309 6.8984
P31/FUJ GDSC1 3.8616 14.7077 -1.2594 33.5907
RS4;11 GDSC1 3.8627 10.1616 1.0111 25.3306
BALL-1 GDSC1 3.9578 4.8043 3.7362 6.1332
KMS-12-BM GDSC1 3.9807 13.8201 -0.7144 31.6694
Karpas-231 GDSC1 3.9924 20.5575 -4.0721 38.3209
MHH-PREB-1 GDSC1 4.0367 4.7582 3.8366 5.0031
MOLT-4 GDSC1 4.1194 4.9389 3.8319 4.6668
HC-1 GDSC1 4.134 5.0043 3.8138 4.7447
OCI-AML-5 GDSC1 4.1365 6.9385 2.8561 12.215
Reh GDSC1 4.1846 5.8972 3.4171 7.649
KE-37 GDSC1 4.199 4.9211 3.9146 3.6873
HL-60 GDSC1 4.2448 10.7262 1.0553 23.6124
JVM-3 GDSC1 4.2458 16.0654 -1.6134 33.2078
ML-2 GDSC1 4.2528 9.8457 1.5022 21.1092
ST486 GDSC1 4.2883 5.5929 3.6582 5.3579
CA46 GDSC1 4.3187 6.47 3.2452 8.5
NKM-1 GDSC1 4.3455 5.7244 3.6402 5.2916
SU-DHL-8 GDSC1 4.3477 12.2159 0.3964 26.3427
CESS GDSC1 4.363 7.4148 2.8096 11.726
P32/ISH GDSC1 4.374 9.1608 1.9457 17.8846
Jiyoye GDSC1 4.3754 10.9045 1.0751 23.0215
TUR GDSC1 4.4309 14.87 -0.8616 30.585
KOPN-8 GDSC1 4.4317 11.7153 0.7163 24.5998
JJN-3 GDSC1 4.4382 10.6703 1.2442 21.8839
YT GDSC1 4.4546 6.8185 3.1824 8.5113
WSU-DLCL2 GDSC1 4.4916 15.3106 -1.0316 30.8891
KM-H2 GDSC1 4.5007 5.7569 3.7474 3.9231
EB2 GDSC1 4.5191 9.4404 1.9251 17.4892
OCI-AML-3 GDSC1 4.5863 14.6274 -0.6122 29.2961
RPMI-8226 GDSC1 4.6316 6.186 3.6337 4.4036
ALL-SIL GDSC1 4.6819 11.0281 1.2639 20.901
KMOE-2 GDSC1 4.7701 10.3878 1.6539 18.3214
LC4-1 GDSC1 4.7932 12.6817 0.528 24.2074
Loucy GDSC1 4.8085 6.2012 3.7503 3.0202
U-698-M GDSC1 4.8558 9.9242 1.9523 16.1379
PF-382 GDSC1 4.8654 6.9063 3.4499 5.1398
MN-60 GDSC1 4.8897 12.286 0.8026 22.5885
NB4 GDSC1 4.9111 7.831 3.0309 8.2105
PL-21 GDSC1 4.9145 10.0741 1.9235 16.1291
KCL-22 GDSC1 5.0609 11.1038 1.5254 18.116
LAMA-84 GDSC1 5.0902 17.2208 -1.499 30.3713
SUP-HD1 GDSC1 5.0939 7.7979 3.1776 6.5704
TK [Human B-cell lymphoma] GDSC1 5.2006 6.6264 3.7933 1.8629
OPM-2 GDSC1 5.2246 12.9056 0.7572 21.7143
Namalwa GDSC1 5.279 9.1135 2.6693 9.8207
ATN-1 GDSC1 5.2791 9.6272 2.4185 11.6138
EM-2 GDSC1 5.311 12.8743 0.8395 21.0363
K-562 GDSC1 5.3249 12.7363 0.9186 20.5951
BC-3 GDSC1 5.3353 18.1748 -1.7791 30.4148
ARH-77 GDSC1 5.389 7.0664 3.7038 2.1075
SR GDSC1 5.3929 22.0747 -3.6785 34.2226
NOMO-1 GDSC1 5.3937 10.7369 1.9579 14.3828
HEL GDSC1 5.412 14.6817 0.0201 24.3944
A4/Fukuda GDSC1 5.6524 8.3918 3.2599 4.5988
HH [Human lymphoma] GDSC1 5.6887 9.8727 2.5864 9.2842
KY821 GDSC1 5.7566 15.2454 0.0049 23.4361
Raji GDSC1 6.0655 14.1844 0.7575 19.1987
CCRF-CEM GDSC1 6.09 14.2933 0.722 19.303
SU-DHL-1 GDSC1 6.0921 13.0545 1.3285 16.1427
ME1 GDSC1 6.1153 7.1945 3.9751 0.1574
JVM-2 GDSC1 6.1334 14.2524 0.7735 18.9305
RPMI-6666 GDSC1 6.1953 7.5579 3.8771 0.369
RL GDSC1 6.2105 17.9397 -0.9842 25.7641
MLMA GDSC1 6.379 8.1475 3.7334 0.7521
Karpas-45 GDSC1 6.3894 16.7147 -0.2473 22.6851
MEG-01 GDSC1 6.4551 15.6615 0.3166 20.1819
RC-K8 GDSC1 6.5003 16.0526 0.1581 20.7491
SUP-T1 GDSC1 6.5838 19.81 -1.6274 26.7692
CTV-1 GDSC1 6.5862 14.1421 1.1468 15.8125
L-1236 GDSC1 6.587 15.7938 0.3466 19.7025
BE-13 GDSC1 6.595 15.5821 0.4553 19.1927
JURL-MK1 GDSC1 6.6248 18.6464 -1.0235 24.8313
Ramos.2G6.4C10 GDSC1 6.6423 24.9313 -4.1186 32.1766
VL51 GDSC1 6.6634 15.3401 0.6212 18.2463
Granta-519 GDSC1 6.7744 17.8986 -0.5468 22.817
P12-Ichikawa GDSC1 6.7862 17.6101 -0.3972 22.2343
L-540 GDSC1 6.8125 8.3547 3.8254 0.2489
WSU-NHL GDSC1 6.9362 17.7273 -0.3467 21.6697
H9 GDSC1 7.0855 20.9549 -1.8189 26.1189
U266B1 GDSC1 7.1417 18.7537 -0.7003 22.4697
Karpas-422 GDSC1 7.2031 14.9802 1.1602 14.2283
ROS-50 GDSC1 7.2689 13.8644 1.7259 10.9736
SCC-3 GDSC1 7.6895 16.1304 0.9328 14.2817
HDLM-2 GDSC1 7.7298 17.6433 0.2425 17.3937
L-428 GDSC1 7.7864 20.8139 -1.2456 22.8264
RPMI-8866 GDSC1 7.7935 31.349 -6.4187 33.4197
DG-75 GDSC1 8.014 19.596 -0.5004 19.7509
DB GDSC1 8.0862 20.7113 -0.9874 21.3253
KMS-11 GDSC1 8.2963 20.1981 -0.5981 19.5065
HT GDSC1 8.4482 23.6219 -2.1431 24.0865
Karpas-299 GDSC1 9.2262 22.3761 -1.0181 19.1188
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 4.2997 5.9272 3.5007 6.5571
KYAE-1 GDSC1 4.4047 13.2244 -0.0605 27.9765
OACP4 C GDSC1 4.4182 5.9011 3.611 5.2676
ESO-26 GDSC1 4.4956 5.9749 3.6354 4.8176
KYSE-50 GDSC1 4.5596 6.3123 3.5172 5.5359
TE-12 GDSC1 4.981 12.1195 0.9579 21.507
KYSE-220 GDSC1 6.01 8.115 3.579 1.8971
FLO-1 GDSC1 6.0287 12.1134 1.7406 13.9204
SK-GT-4 GDSC1 6.2954 8.6569 3.4945 1.986
ESO-51 GDSC1 6.3793 16.6844 -0.2398 22.6829
HCE-4 GDSC1 8.105 17.6755 0.4733 15.5519
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 5.2917 12.1722 1.1728 19.368
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-7 GDSC1 -5.1152 -1.3861 -5.1282 92.5113
SK-N-BE(2)-M17 GDSC1 -1.3952 0.7028 -1.4 70.4481
SJNB-5 GDSC1 -1.2821 0.3324 -1.2828 69.7093
SK-N-DZ GDSC1 -1.281 2.1119 -1.3609 66.8351
GI-ME-N GDSC1 0.1194 47.8882 -21.0554 50.2322
GOTO GDSC1 0.6673 6.194 -0.2979 47.1473
Kelly GDSC1 2.0598 8.133 0.3116 36.8193
SJNB-17 GDSC1 2.079 5.4883 1.4799 31.6708
SJNB-10 GDSC1 2.6725 7.6892 1.123 30.199
SiMa GDSC1 2.869 6.4547 1.8908 24.8117
CHP-134 GDSC1 3.2075 4.7764 2.9572 15.6306
CHP-212 GDSC1 3.2992 5.1355 2.9126 15.4745
SK-N-MC-IXC GDSC1 3.5369 10.8349 0.3901 29.4946
NB1 GDSC1 3.8833 15.9889 -1.881 34.9723
CHP-126 GDSC1 3.9117 5.1937 3.5102 8.0606
KP-N-YS GDSC1 3.9762 6.9412 2.7141 13.9327
SJNB-12 GDSC1 4.0836 5.2535 3.6451 6.2685
LA-N-6 GDSC1 4.28 6.1804 3.3575 7.758
NB69 GDSC1 4.5884 6 3.6933 4.0727
SJNB-13 GDSC1 4.6195 6.6875 3.377 6.4397
NH-12 GDSC1 4.9168 9.1776 2.3703 13.0815
IMR-5 GDSC1 5.3863 10.2677 2.1827 12.9202
MHH-NB-11 GDSC1 5.4931 7.0973 3.7459 1.6719
SK-N-FI GDSC1 5.5162 8.4879 3.1303 5.8321
KP-N-YN GDSC1 6.0926 17.1533 -0.6845 25.076
SK-N-SH GDSC1 6.3108 13.1187 1.4505 14.8651
NB(TU)1 GDSC1 6.5803 18.2224 -0.8478 24.3605
TGW GDSC1 7.266 14.8749 1.251 13.6043
SK-N-AS GDSC1 7.5343 16.2897 0.7568 15.4881
SJNB-14 GDSC1 7.6744 16.7246 0.6426 15.7138
SJNB-6 GDSC1 7.8428 24.0747 -2.796 26.9788
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 6.4701 8.2027 3.7499 0.6262
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 -1.1266 4.0952 -1.5639 62.2317
HCC2218 GDSC1 -0.0881 6.0971 -1.0702 53.1278
MCF-7 GDSC1 0.0577 3.4278 -0.1216 52.8475
MDA-MB-468 GDSC1 0.4569 6.374 -0.5918 48.9358
MDA-MB-453 GDSC1 1.047 8.3536 -0.8082 45.1369
MDA-MB-415 GDSC1 1.0557 4.7173 0.6421 42.3905
HCC1500 GDSC1 1.1915 9.5979 -1.2286 44.8017
UACC-893 GDSC1 2.1969 6.3697 1.2422 32.2191
BT-474 GDSC1 3.0973 9.5928 0.6074 30.4963
MRK-nu-1 GDSC1 3.4178 8.0462 1.6614 23.6127
BT-549 GDSC1 3.5047 8.6894 1.4246 24.6195
MDA-MB-175-VII GDSC1 4.4999 7.7191 2.7692 11.5473
DU4475 GDSC1 4.5893 5.834 3.7755 3.4328
T-47D GDSC1 4.6891 6.6986 3.424 5.8566
CAL-148 GDSC1 4.7015 12.044 0.7725 23.3773
HCC1569 GDSC1 4.7933 8.4612 2.6308 11.5951
HCC1419 GDSC1 4.8106 13.5248 0.1211 25.8904
HCC2157 GDSC1 4.889 14.4058 -0.2555 27.0834
HCC1806 GDSC1 4.8908 6.9315 3.4555 5.0263
CAL-120 GDSC1 5.0431 7.7972 3.1425 6.9776
COLO 824 GDSC1 5.0544 10.053 2.0416 14.894
HCC1937 GDSC1 5.3603 7.9288 3.293 5.0285
MDA-MB-330 GDSC1 5.422 10.0196 2.3297 11.8122
EFM-192A GDSC1 5.4328 9.1093 2.7789 8.5959
ZR-75-30 GDSC1 5.5089 13.5196 0.6709 21.2442
UACC-812 GDSC1 5.6303 8.7224 3.093 5.8285
HDQ-P1 GDSC1 5.727 8.0327 3.4653 3.0519
HCC1395 GDSC1 5.7836 8.2361 3.4069 3.3315
HCC70 GDSC1 5.8193 10.8951 2.1841 11.678
BT-20 GDSC1 5.8482 12.964 1.1974 17.5522
Evsa-T GDSC1 5.8851 16.3323 -0.4355 24.7621
HCC38 GDSC1 5.8961 8.9416 3.1548 4.8082
HCC1428 GDSC1 5.9732 11.3569 2.0673 12.0252
CAL-85-1 GDSC1 6.3028 12.8454 1.5767 14.1604
CAMA-1 GDSC1 6.3683 14.5795 0.7823 18.246
HCC1954 GDSC1 6.5677 13.8812 1.2596 15.2547
Hs 578T GDSC1 6.6098 8.4142 3.7278 0.6142
MFM-223 GDSC1 6.6444 15.0493 0.7488 17.6835
MDA-MB-157 GDSC1 6.765 9.061 3.5484 1.2031
JIMT-1 GDSC1 6.8383 15.5821 0.626 17.7781
MDA-MB-361 GDSC1 6.933 17.9978 -0.4809 22.1818
EFM-19 GDSC1 6.9597 8.768 3.735 0.4089
MDA-MB-231 GDSC1 7.0192 19.758 -1.2799 24.6864
HCC1187 GDSC1 7.4337 20.2492 -1.2209 23.5367
MDA-MB-436 GDSC1 7.6035 17.7289 0.1167 18.2181
YMB-1-E GDSC1 8.0743 23.0892 -2.1481 24.8627
HCC1599 GDSC1 8.2392 22.2892 -1.6436 23.088
AU565 GDSC1 8.4344 19.6417 -0.2414 17.8647
BT-483 GDSC1 8.7173 23.1543 -1.7307 22.3764
CAL-51 GDSC1 10.1633 25.8439 -2.047 20.6123
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-247MG GDSC1 -2.2972 9.0944 -4.5957 61.8212
KS-1 [Human Krukenberg tumour] GDSC1 -0.2989 1.1111 -0.2998 57.7247
Daoy GDSC1 0.4117 7.3613 -1.037 49.3722
AM-38 GDSC1 1.084 5.1176 0.543 42.4502
SK-MG-1 GDSC1 3.1061 15.0685 -2.0955 37.99
GaMG GDSC1 3.4378 8.4445 1.4842 24.5747
GB-1 GDSC1 3.8717 4.3528 3.8218 5.9574
Hs 683 GDSC1 4.0559 7.301 2.6053 14.436
D-423MG GDSC1 4.0613 18.5222 -2.9965 36.5467
SF268 GDSC1 4.0947 5.1526 3.7048 5.758
U-251MG GDSC1 4.297 12.172 0.3761 26.6127
NMC-G1 GDSC1 4.715 7.6129 2.9915 9.1243
YH-13 GDSC1 4.7622 6.012 3.8096 2.6966
LN-405 GDSC1 5.0705 6.6035 3.7282 2.5655
MOG-G-CCM GDSC1 5.301 10.8473 1.8349 15.4544
SF539 GDSC1 5.3071 7.134 3.6273 2.7727
DK-MG GDSC1 5.3423 7.3784 3.5371 3.3242
SW1088 GDSC1 5.5288 7.7444 3.4811 3.3265
KNS-42 GDSC1 5.5311 8.0114 3.361 4.1529
H4 GDSC1 5.5806 9.665 2.6127 9.387
ONS-76 GDSC1 5.5872 7.8902 3.4494 3.4259
SF295 GDSC1 5.6616 11.3157 1.8689 14.1586
LNZTA3WT4 GDSC1 5.7924 18.2771 -1.4712 28.3462
SNB-75 GDSC1 5.8725 8.5197 3.331 3.6665
D-502MG GDSC1 5.8879 8.0619 3.5394 2.3099
D-336MG GDSC1 5.9742 9.8069 2.8037 7.06
KNS-81-FD GDSC1 6.0331 13.0254 1.3007 16.4608
U-87MG ATCC GDSC1 6.1392 7.5423 3.861 0.4507
KINGS-1 GDSC1 6.1464 10.3047 2.6799 7.5111
LN-229 GDSC1 6.2604 8.4216 3.5739 1.6036
U-118MG GDSC1 6.3271 12.3599 1.8262 12.6099
42-MG-BA GDSC1 6.3601 9.6887 3.0864 4.3582
CAS-1 GDSC1 6.3606 19.127 -1.4578 26.8337
M059J GDSC1 6.3721 8.9319 3.4182 2.3097
SF126 GDSC1 6.4066 12.5848 1.7721 12.7351
D283 Med GDSC1 6.4564 7.6627 3.9358 0.1392
LN-18 GDSC1 6.5025 14.157 1.0817 16.3721
D-392MG GDSC1 6.5604 12.5206 1.9043 11.5511
A-172 GDSC1 6.6548 15.5399 0.5182 18.7493
KALS-1 GDSC1 6.6593 10.9537 2.692 6.3323
D-263MG GDSC1 6.6685 15.6033 0.4971 18.8112
SW1783 GDSC1 6.6983 14.5047 1.049 16.038
Onda 10 GDSC1 6.8093 14.097 1.3196 14.3211
8-MG-BA GDSC1 6.9735 14.5919 1.1931 14.6008
MOG-G-UVW GDSC1 6.9765 9.1382 3.6074 0.8011
GI-1 GDSC1 7.1093 14.8263 1.1716 14.3896
YKG-1 GDSC1 7.1262 14.4914 1.3413 13.4437
PFSK-1 GDSC1 7.184 18.1774 -0.3897 21.2308
D-542MG GDSC1 7.2024 19.7881 -1.1617 23.8815
Onda 11 GDSC1 7.4363 16.5671 0.5599 16.6424
Becker GDSC1 8.0485 17.7994 0.3783 16.097
DBTRG-05MG GDSC1 8.5638 16.1337 1.4645 9.8149
D-566MG GDSC1 8.882 22.1883 -1.1563 20.2514
T98G GDSC1 9.9946 21.1587 0.0297 13.8224
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.1612 5.436 0.5149 41.9405
TGBC24TKB GDSC1 4.9875 9.9268 2.053 15.0355
TGBC1TKB GDSC1 7.9091 18.3359 0.0318 17.887
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 5.2536 10.1998 2.1187 13.7524
KLE GDSC1 5.4397 10.5746 2.0712 13.5052
RL95-2 GDSC1 6.1606 16.1862 -0.1562 22.9446
MFE-319 GDSC1 6.3772 24.3919 -4.0559 32.6331
ESS-1 GDSC1 7.1566 14.4208 1.3943 13.0843
AN3-CA GDSC1 7.265 14.5453 1.4055 12.7749
MFE-296 GDSC1 9.1217 22.4286 -1.1117 19.6348
EN GDSC1 10.1339 26.1886 -2.2298 21.1776
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC1 -3.3161 0.1209 -3.3396 84.2013
Caki-1 GDSC1 -1.007 2.9574 -1.186 63.1343
KTCTL-1M GDSC1 1.5149 8.0788 -0.2103 41.3576
KTCTL-140 GDSC1 3.0998 9.9007 0.4584 31.1005
BB65-RCC GDSC1 3.2029 7.5087 1.7213 24.2373
A-704 GDSC1 4.2086 8.3672 2.204 16.7542
LB1047-RCC GDSC1 4.7713 9.2656 2.2138 14.6606
LB2241-RCC GDSC1 5.0355 12.8014 0.6612 22.7847
RXF 393L GDSC1 5.0502 8.1125 2.994 8.0784
SN12C GDSC1 5.0524 24.8248 -5.3273 37.3466
KTCTL-195 GDSC1 5.1005 17.9252 -1.8423 31.2261
RCC10RGB GDSC1 5.1157 9.0845 2.5655 11.0566
VMRC-RCZ GDSC1 5.2038 8.6279 2.8523 8.6949
NCC021 GDSC1 5.2457 10.4228 2.0029 14.5441
A-498 GDSC1 5.2584 11.5258 1.4676 17.8183
VMRC-RCW GDSC1 5.3156 12.7255 0.9168 20.634
LB996-RCC GDSC1 5.5413 11.9818 1.4546 17.0179
UO-31 GDSC1 5.6152 11.1375 1.9226 13.953
KTCTL-13 GDSC1 5.68 8.2946 3.3208 4.1173
TK-10 GDSC1 5.8279 10.3391 2.457 9.8163
SW156 GDSC1 5.8952 12.0626 1.6715 14.707
KMRC-1 GDSC1 5.9577 14.1984 0.6717 19.9184
KTCTL-26A GDSC1 6.0506 13.1127 1.2707 16.5777
HA7-RCC GDSC1 6.3566 14.3123 0.9041 17.6714
OS-RC-2 GDSC1 6.4067 13.1188 1.5163 14.2381
CAL-54 GDSC1 6.7375 8.5042 3.7449 0.4863
BFTC-909 GDSC1 6.8235 17.8533 -0.4892 22.4835
SW13 GDSC1 6.9518 18.5635 -0.7439 23.0809
786-O GDSC1 8.6567 18.5864 0.3973 14.7543
KMRC-20 GDSC1 8.7519 19.3209 0.1145 15.7769
769-P GDSC1 9.1763 23.6459 -1.6553 21.2572
ACHN GDSC1 10.0462 23.7967 -1.1585 18.0819
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW626 GDSC1 -1.859 9.1449 -4.1566 60.2052
HT115 GDSC1 -0.4096 8.2973 -2.2869 54.2499
SNU-175 GDSC1 -0.3589 3.1179 -0.5152 57.2212
NCI-H747 GDSC1 -0.0842 6.146 -1.0841 53.0821
SW1463 GDSC1 0.3833 124.059 -58.8597 49.9728
SNU-407 GDSC1 1.9423 6.8819 0.7574 35.8991
HT-55 GDSC1 2.0699 6.1107 1.2197 33.0847
LoVo GDSC1 2.2866 6.4729 1.29 31.4573
RKO GDSC1 3.9022 11.144 0.5551 27.3266
CCK-81 GDSC1 4.2305 6.001 3.405 7.5691
C2BBe1 GDSC1 4.9711 7.6842 3.1463 7.154
LS411N GDSC1 4.9976 6.7657 3.6068 3.6107
LS1034 GDSC1 5.2876 9.137 2.664 9.8348
T84 GDSC1 5.4738 13.5114 0.6483 21.4589
SNU-1040 GDSC1 5.49 13.4861 0.6732 21.2912
LS123 GDSC1 5.5598 10.9661 1.9665 13.833
SNU-81 GDSC1 5.5755 13.8687 0.5488 21.6164
CW-2 GDSC1 5.596 13.3029 0.844 20.1367
SW948 GDSC1 5.774 12.868 1.1904 17.8061
SW1116 GDSC1 5.8658 7.6106 3.7166 1.3277
GP5d GDSC1 5.8798 12.5282 1.4335 16.1462
SW1417 GDSC1 5.9312 12.2732 1.5946 15.0647
HCC2998 GDSC1 5.9444 11.0045 2.217 11.1255
SW837 GDSC1 6.1739 13.8721 0.9885 17.7381
LS513 GDSC1 6.1844 13.5791 1.1387 16.922
NCI-H716 GDSC1 6.2643 8.0648 3.7165 0.915
SNU-C1 GDSC1 6.492 19.18 -1.3852 26.2903
MDST8 GDSC1 6.5658 13.1362 1.6154 13.2595
COLO 678 GDSC1 6.6378 8.3362 3.7671 0.4713
SNU-61 GDSC1 6.6788 14.603 0.9883 16.4003
HT-29 GDSC1 6.7006 13.5131 1.5255 13.4416
SW48 GDSC1 6.8268 18.4501 -0.779 23.5095
CL-11 GDSC1 7.06 18.8315 -0.7968 23.0031
KM12 GDSC1 7.0943 15.778 0.7072 16.7596
HCT 116 GDSC1 7.3257 16.0392 0.7379 16.0603
SNU-C2B GDSC1 7.6495 17.5421 0.2371 17.5984
COLO 320HSR GDSC1 7.6574 19.8739 -0.8802 21.9018
COLO205 GDSC1 7.6963 19.5962 -0.7186 21.2491
LS180 GDSC1 7.9135 18.5058 -0.0463 18.1988
SNU-C5 GDSC1 8.3483 23.6374 -2.2208 24.4977
CaR-1 GDSC1 8.4805 19.3186 -0.0585 17.0393
HCT 15 GDSC1 8.5687 17.8461 0.6861 13.6258
RCM-1 [Human ESC] GDSC1 9.5202 20.8127 -0.0991 15.181
SW620 GDSC1 9.5863 21.4992 -0.3764 16.1367
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 0.1834 5.5011 -0.5639 51.1751
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Huh-7 GDSC1 -0.3836 1.2153 -0.3859 58.7356
SNU-449 GDSC1 1.7763 7.8962 0.1363 38.9624
JHH-7 GDSC1 3.0179 9.8596 0.4033 31.689
JHH-1 GDSC1 3.8162 12.315 -0.1035 30.2706
JHH-4 GDSC1 4.0707 4.7967 3.8525 4.725
HLE GDSC1 4.1724 7.0405 2.8361 12.2312
SNU-423 GDSC1 4.3332 5.7047 3.6399 5.3382
SK-HEP-1 GDSC1 4.8389 13.3063 0.253 25.2528
SNU-475 GDSC1 5.0331 6.6024 3.7058 2.8066
Hep-G2/C3A GDSC1 5.0534 8.8827 2.6187 10.8599
SNU-387 GDSC1 5.3508 7.4463 3.5111 3.4885
JHH-2 GDSC1 6.0258 9.2221 3.104 4.8865
JHH-6 GDSC1 6.332 16.735 -0.2995 23.0376
SNU-398 GDSC1 6.7069 16.0669 0.2988 19.6038
Hep 3B2.1-7 GDSC1 7.6375 18.5391 -0.2492 19.6295
HuH-1 GDSC1 7.926 19.358 -0.4459 19.7395
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H838 GDSC1 -2.0153 0.6359 -2.0279 75.9035
DMS 53 GDSC1 -1.5948 6.8883 -2.981 61.2302
NCI-H64 GDSC1 -1.4125 -0.446 -1.4125 71.6489
SHP-77 GDSC1 -0.9103 11.6705 -4.2821 55.1538
NCI-H460 GDSC1 -0.1257 3.4634 -0.3274 54.6971
NCI-H82 GDSC1 0.1121 2.0893 0.0955 52.5612
NCI-H847 GDSC1 0.1751 8.773 -1.8853 50.8639
NCI-H510A GDSC1 0.1872 4.3083 -0.1867 51.3268
NCI-H1688 GDSC1 1.0529 17.4259 -5.1204 47.6066
LCLC-103H GDSC1 1.2805 2.7295 1.2676 38.0943
IST-SL2 GDSC1 1.524 5.117 1.0196 37.5371
NCI-H2196 GDSC1 1.528 6.124 0.644 38.9435
SBC-1 GDSC1 1.5473 5.6085 0.866 38.0026
NCI-H3122 GDSC1 1.605 7.2244 0.261 39.6381
SBC-5 GDSC1 1.7229 7.0976 0.4376 38.3751
NCI-H647 GDSC1 2.0734 9.3029 -0.2234 38.3155
NCI-H1836 GDSC1 2.4511 14.2796 -2.2907 40.6499
LCLC-97TM1 GDSC1 2.7454 8.1615 0.9699 30.5653
NCI-H69 GDSC1 2.753 13.7325 -1.7473 38.6392
DMS 273 GDSC1 2.8218 8.2445 1.0036 30.0231
NCI-H1755 GDSC1 3.0522 7.1245 1.7601 24.7218
COR-L88 GDSC1 3.1326 18.1108 -3.5871 40.1067
SBC-3 GDSC1 3.1623 11.5925 -0.3198 33.5816
NCI-H2342 GDSC1 3.275 11.9669 -0.4046 33.3829
NCI-H1694 GDSC1 3.2964 11.2974 -0.0534 32.1553
COR-L105 GDSC1 3.401 10.4061 0.482 29.6856
CAL-12T GDSC1 3.5292 12.339 -0.365 32.2543
UMC-11 GDSC1 3.6677 10.2145 0.8142 27.0911
COLO 668 GDSC1 3.7179 9.764 1.0825 25.5593
COR-L303 GDSC1 3.7553 5.392 3.2637 10.6532
NCI-H1092 GDSC1 3.7912 8.3864 1.8321 20.9224
NCI-H810 GDSC1 3.7986 6.7761 2.6354 15.2579
NCI-H211 GDSC1 4.0101 16.2214 -1.8896 34.5865
Ms-1 GDSC1 4.0506 10.6516 0.9282 25.0015
NCI-H1436 GDSC1 4.0713 8.4325 2.0542 18.3184
NCI-H2731 GDSC1 4.0923 5.4452 3.559 6.9036
RERF-LC-MS GDSC1 4.1047 11.7325 0.4341 27.0755
NCI-H748 GDSC1 4.1815 8.6022 2.0636 17.8246
NCI-H2029 GDSC1 4.2384 6.8343 2.9954 10.7498
NCI-H2369 GDSC1 4.3332 10.2807 1.3519 21.6726
EPLC-272H GDSC1 4.3471 12.3453 0.3312 26.6217
NCI-H1437 GDSC1 4.3522 6.6921 3.162 9.0322
NCI-H2081 GDSC1 4.4183 9.7175 1.704 19.2676
NCI-H196 GDSC1 4.4269 6.3049 3.4165 6.7686
HOP-62 GDSC1 4.4374 11.5407 0.8083 24.1387
NCI-H441 GDSC1 4.4507 14.1152 -0.4678 29.2676
NCI-H2227 GDSC1 4.457 5.749 3.7176 4.2986
SK-MES-1 GDSC1 4.5162 8.2457 2.5195 13.3582
EMC-BAC-1 GDSC1 4.5388 6.4235 3.446 6.1611
COR-L321 GDSC1 4.5575 6.3293 3.5072 5.6213
COR-L311 GDSC1 4.6184 11.6317 0.9111 22.9851
Lu-134-A GDSC1 4.6484 10.5288 1.4862 19.752
NCI-H187 GDSC1 4.6632 6.9499 3.2803 7.0545
NCI-H1304 GDSC1 4.6792 7.2433 3.1473 8.0367
NCI-H2869 GDSC1 4.8382 7.0951 3.3386 6.0704
COR-L95 GDSC1 4.8475 10.4291 1.6945 17.8064
HCC44 GDSC1 4.8608 8.0037 2.9085 9.2955
NCI-H1155 GDSC1 4.8611 11.2493 1.2967 20.0991
NCI-H2804 GDSC1 4.8716 8.6651 2.5897 11.644
NCI-H727 GDSC1 4.9808 9.2833 2.3667 12.9002
NCI-H290 GDSC1 5.0256 18.1363 -2.008 31.8362
NCI-H1048 GDSC1 5.0485 19.6935 -2.7671 33.4175
NCI-H841 GDSC1 5.0855 21.5803 -3.6795 34.9694
NCI-H1563 GDSC1 5.0887 11.9606 1.1213 20.2975
ABC-1 GDSC1 5.0913 25.3565 -5.5612 37.5351
NCI-H524 GDSC1 5.092 11.0432 1.5795 17.692
Lu-65 GDSC1 5.1007 9.6899 2.2561 13.2929
NCI-H2087 GDSC1 5.168 9.755 2.2742 12.9582
NCI-H446 GDSC1 5.1826 6.8603 3.6781 2.6781
NCI-H2030 GDSC1 5.2098 6.8758 3.6871 2.5598
IST-SL1 GDSC1 5.2249 6.9288 3.672 2.633
PC-14 GDSC1 5.2264 8.1803 3.0845 6.9066
NCI-H2135 GDSC1 5.2389 7.6942 3.3251 5.0901
HARA [Human squamous cell lung carcinoma] GDSC1 5.2913 7.0147 3.6718 2.5009
RERF-LC-KJ GDSC1 5.3056 7.8471 3.2963 5.1371
Lu-165 GDSC1 5.3496 8.991 2.7784 8.8275
NCI-H358 GDSC1 5.3587 10.0178 2.285 12.3057
SW1271 GDSC1 5.4004 8.7116 2.9478 7.4519
Lu-135 GDSC1 5.4408 10.9121 1.9064 14.5718
PaCa-3 GDSC1 5.4584 9.0203 2.8391 8.0904
NCI-H2347 GDSC1 5.4597 7.5629 3.5227 3.1811
NCI-H1838 GDSC1 5.4669 7.4754 3.5662 2.8715
NCI-H1648 GDSC1 5.4675 14.0288 0.387 22.6758
NCI-H1944 GDSC1 5.4703 14.3789 0.2155 23.4106
NCI-H2110 GDSC1 5.4747 8.3072 3.1886 5.5108
BEN GDSC1 5.4933 17.1529 -1.1454 28.2167
CPC-N GDSC1 5.5456 13.221 0.8465 20.2766
NCI-H1781 GDSC1 5.5822 7.2508 3.7265 1.6532
NCI-H1975 GDSC1 5.588 11.1877 1.8784 14.3126
NCI-H650 GDSC1 5.6082 8.5437 3.1624 5.3852
NCI-H1876 GDSC1 5.6093 17.0685 -1.0128 27.4843
NCI-H596 GDSC1 5.6692 8.555 3.195 5.0169
NCI-H2141 GDSC1 5.6733 18.5588 -1.704 29.3032
A-427 GDSC1 5.6861 11.432 1.8297 14.3335
NCI-H2722 GDSC1 5.7057 7.3926 3.7289 1.4648
SK-LU-1 GDSC1 5.7299 8.5018 3.2561 4.4591
NCI-H23 GDSC1 5.7385 7.9742 3.4975 2.8219
NCI-H2171 GDSC1 5.7531 12.5156 1.3479 16.9974
NCI-H1770 GDSC1 5.8079 16.0344 -0.3467 24.6523
LC-2/ad GDSC1 5.8115 8.8446 3.1484 5.0312
NCI-H1623 GDSC1 5.8193 8.4526 3.3307 3.7708
LC-1/sq GDSC1 5.8518 12.3621 1.4945 15.875
DMS 79 GDSC1 5.8875 14.3125 0.5638 20.6287
Lu-139 GDSC1 5.9784 15.8238 -0.1137 23.2802
NCI-H3255 GDSC1 6.0022 11.8377 1.8555 13.2871
NCI-H322M GDSC1 6.0059 8.7884 3.2868 3.7078
NCI-H209 GDSC1 6.0273 10.8235 2.359 9.9671
NCI-H1666 GDSC1 6.0395 10.8148 2.3711 9.855
NCI-H1915 GDSC1 6.0496 8.0661 3.6185 1.6252
NCI-H292 GDSC1 6.0527 10.9721 2.3051 10.2614
HCC78 GDSC1 6.0641 13.4527 1.1145 17.384
NCI-H1573 GDSC1 6.0795 13.339 1.1809 16.9856
NCI-H345 GDSC1 6.2064 15.5261 0.2022 21.3492
NCI-H513 GDSC1 6.2233 10.4772 2.6476 7.5535
NCI-H2461 GDSC1 6.2389 9.1239 3.2676 3.4188
NCI-H2023 GDSC1 6.2426 7.7466 3.8271 0.5022
NCI-H520 GDSC1 6.2452 16.1486 -0.0752 22.3934
EKVX GDSC1 6.2567 11.7765 2.0576 11.3507
NCI-H1993 GDSC1 6.2672 8.1267 3.6939 1.012
NCI-H2122 GDSC1 6.2868 7.9961 3.7522 0.7484
NCI-H2228 GDSC1 6.308 8.5723 3.5352 1.7497
HCC33 GDSC1 6.3085 14.06 0.9927 17.3492
NCI-H2291 GDSC1 6.3169 9.0135 3.3561 2.7516
NCI-H1869 GDSC1 6.3323 13.3283 1.3641 15.2939
NCI-H1693 GDSC1 6.363 8.055 3.7615 0.6567
NCI-H226 GDSC1 6.3741 21.7803 -2.7615 30.1172
NCI-H2170 GDSC1 6.3818 12.3961 1.8456 12.3529
NCI-H526 GDSC1 6.3925 17.8283 -0.7929 24.6555
NCI-H1703 GDSC1 6.4089 17.4862 -0.6123 23.9853
HCC15 GDSC1 6.4213 9.2679 3.3017 2.9164
NCI-H661 GDSC1 6.4366 20.9982 -2.3261 28.9608
LOU-NH91 GDSC1 6.5387 8.4364 3.6907 0.7987
NCI-H1734 GDSC1 6.5934 8.553 3.6695 0.8405
NCI-H2405 GDSC1 6.5964 11.5794 2.3681 8.5545
COR-L23 GDSC1 6.6216 14.1754 1.155 15.6781
LXF 289 GDSC1 6.6257 11.9265 2.2252 9.3999
NCI-H2085 GDSC1 6.6282 8.8383 3.5752 1.209
Calu-3 GDSC1 6.6398 8.5245 3.6991 0.6959
NCI-H2803 GDSC1 6.6494 8.3315 3.7732 0.4471
NCI-H2795 GDSC1 6.6545 8.2599 3.8006 0.3677
NCI-H522 GDSC1 6.656 9.9871 3.1167 3.6614
NCI-H1581 GDSC1 6.7365 21.3335 -2.265 28.1043
NCI-H2009 GDSC1 6.7556 20.6152 -1.8961 27.1007
NCI-H1299 GDSC1 6.7694 8.4795 3.7659 0.4103
NCI-H2373 GDSC1 6.7711 14.9652 0.8773 16.727
NCI-H1650 GDSC1 6.7742 8.9578 3.5918 1.0106
Lu-99A GDSC1 6.7853 16.4184 0.1834 19.9048
HCC827 GDSC1 6.8438 8.2834 3.8609 0.1726
HOP-92 GDSC1 6.8471 9.2759 3.5008 1.339
NCI-H2818 GDSC1 6.8477 13.6865 1.5403 12.9994
NCI-H2444 GDSC1 6.8721 15.6235 0.6294 17.6772
ChaGo-K-1 GDSC1 6.9182 8.5342 3.8014 0.2655
NCI-H2595 GDSC1 6.9969 9.0496 3.6481 0.6481
NCI-H720 GDSC1 7.0649 17.3341 -0.0642 20.2419
IA-LM GDSC1 7.101 17.0323 0.1073 19.4437
RERF-LC-Sq1 GDSC1 7.1572 13.8972 1.6405 11.7088
A-549 GDSC1 7.2786 12.042 2.5584 5.9976
DMS 114 GDSC1 7.3112 21.6802 -2.0095 26.1302
NCI-H1793 GDSC1 7.3333 18.0826 -0.2391 20.2953
EMC-BAC-2 GDSC1 7.3554 15.4417 1.0413 14.4893
NCI-H2172 GDSC1 7.4231 15.4997 1.058 14.2493
EBC-1 GDSC1 7.4905 17.1805 0.3031 17.6749
NCI-H1355 GDSC1 7.5511 17.7364 0.0776 18.5029
NCI-H2591 GDSC1 7.6078 9.6077 3.6788 0.3036
SW1573 GDSC1 7.7046 18.0447 0.0338 18.3354
NCI-H1568 GDSC1 7.8286 24.5864 -3.0572 27.6111
Calu-6 GDSC1 7.8857 17.7398 0.3 16.7963
NCI-H1792 GDSC1 7.9315 15.1993 1.5158 10.7525
NCI-H1435 GDSC1 8.0628 17.9097 0.3355 16.2553
LK-2 GDSC1 8.33 25.4863 -3.1344 26.7881
NCI-H1651 GDSC1 9.0089 22.6686 -1.3007 20.4732
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 5.0256 7.3529 3.3452 5.4932
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EC-GI-10 GDSC1 2.7979 5.3361 2.3031 22.4182
OE19 GDSC1 2.9512 9.9075 0.3181 32.3204
KYSE-450 GDSC1 4.6746 5.7914 3.8562 2.5748
KYSE-140 GDSC1 4.7105 6.4922 3.5411 4.8851
TE-15 GDSC1 5.1905 11.6809 1.3388 18.7729
T.T GDSC1 5.2488 10.5403 1.9473 14.8968
TE-6 GDSC1 5.628 11.9696 1.5244 16.3523
KYSE-410 GDSC1 5.8227 7.9154 3.568 2.2379
TE-10 GDSC1 5.8547 7.7743 3.6439 1.7421
KYSE-520 GDSC1 5.9276 7.8123 3.6638 1.5342
KYSE-270 GDSC1 5.9433 10.9881 2.2241 11.0814
TE-8 GDSC1 5.9972 9.5547 2.9349 6.1022
TE-4 GDSC1 6.5036 22.0805 -2.8112 29.9267
KYSE-180 GDSC1 6.5508 13.3856 1.4861 14.0402
COLO 680N GDSC1 6.552 7.979 3.8614 0.2577
TE-1 GDSC1 6.8618 18.866 -0.9573 24.0279
OE21 GDSC1 6.8694 8.5017 3.7951 0.2962
OE33 GDSC1 6.8845 8.7005 3.7306 0.455
KYSE-510 GDSC1 7.5746 14.3942 1.6692 10.6416
KYSE-70 GDSC1 7.9571 16.7993 0.7901 14.3954
TE-5 GDSC1 8.2888 16.7364 1.0266 12.5568
TE-11 GDSC1 8.9536 18.6272 0.5617 13.4466
TE-9 GDSC1 9.6476 18.5574 0.9997 10.2109
KYSE-150 GDSC1 10.1518 26.0961 -2.1741 20.9916
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 2.2603 11.4858 -1.0957 39.4095
TOV-112D GDSC1 2.5109 8.9692 0.3582 34.2806
OAW42 GDSC1 3.5268 11.0646 0.267 30.0281
Caov-4 GDSC1 3.6439 5.9346 2.8987 13.9358
OAW28 GDSC1 4.5865 6.6285 3.381 6.5142
IGROV-1 GDSC1 4.6558 6.8899 3.3045 6.8897
OVK18 GDSC1 4.7523 6.7471 3.4466 5.4913
ES-2 GDSC1 4.7622 13.9939 -0.1523 27.1131
FU-OV-1 GDSC1 4.9339 8.7008 2.6192 11.2285
RMG-I GDSC1 5.2175 11.3697 1.5137 17.6785
SK-OV-3 GDSC1 5.2182 7.5015 3.4026 4.5719
JHOS-2 GDSC1 5.2752 8.7347 2.8507 8.5052
OVKATE GDSC1 5.5276 7.3422 3.6588 2.1557
OC 314 GDSC1 5.6465 17.171 -1.0348 27.4492
TYK-nu GDSC1 5.7153 9.729 2.6729 8.6074
TOV-21G GDSC1 5.7232 7.8242 3.5546 2.4832
OV56 GDSC1 5.7604 7.0143 3.9039 0.5516
OVISE GDSC1 5.8072 10.0907 2.5617 9.1476
Caov-3 GDSC1 5.8716 12.2984 1.5398 15.5548
DOV13 GDSC1 6.1303 9.0195 3.254 3.6947
Kuramochi GDSC1 6.6886 8.4434 3.748 0.5027
OVCAR-3 GDSC1 6.7392 8.2437 3.8373 0.2472
OVTOKO GDSC1 6.7744 12.5276 2.0384 10.2252
OV-90 GDSC1 6.9553 15.7424 0.6294 17.4699
OVCAR-4 GDSC1 7.2083 20.5717 -1.541 25.0378
OVCAR-5 GDSC1 7.2874 8.9949 3.7747 0.2116
EFO-21 GDSC1 7.3451 15.5765 0.9707 14.8704
OVCAR-8 GDSC1 7.9031 33.1074 -7.2061 34.1973
EFO-27 GDSC1 8.9599 18.5912 0.5821 13.343
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 -0.9996 8.0319 -2.7956 57.4073
HPAF-II GDSC1 3.9724 8.4362 1.9667 19.2994
SUIT-2 GDSC1 4.9717 7.4437 3.2638 6.2588
Panc 10.05 GDSC1 5.1014 9.2839 2.4568 11.8814
HuP-T3 GDSC1 5.1149 9.206 2.5051 11.4941
SU.86.86 GDSC1 5.2798 8.2881 3.0691 6.878
HuP-T4 GDSC1 5.4465 7.451 3.5655 2.9164
KP-3 GDSC1 5.4898 8.1855 3.255 4.9973
KP-2 GDSC1 5.7174 7.0849 3.8583 0.7854
Panc 03.27 GDSC1 5.7881 11.4413 1.8978 13.6151
MZ-PC-1 GDSC1 5.8115 9.3612 2.9091 6.7051
CFPAC-1 GDSC1 5.8279 7.5314 3.7309 1.2982
Panc 08.13 GDSC1 5.8992 12.3435 1.5376 15.4898
Capan-1 GDSC1 6.363 13.2447 1.4257 14.8675
QGP-1 GDSC1 6.4025 20.0198 -1.8677 27.8753
DAN-G GDSC1 6.8996 21.8342 -2.3898 28.0386
Panc 04.03 GDSC1 6.9329 8.3288 3.8764 0.1293
PaTu 8902 GDSC1 6.9587 15.8503 0.5798 17.6948
HPAC GDSC1 7.0555 20.0038 -1.3739 24.8907
AsPC-1 GDSC1 7.1692 9.1523 3.6773 0.4712
PL4 GDSC1 7.4893 24.1554 -3.0948 28.3936
YAPC GDSC1 7.6214 15.6746 1.1033 13.5738
BxPC-3 GDSC1 7.8541 18.7255 -0.1913 18.9141
PSN1 GDSC1 8.0649 19.0082 -0.1849 18.4259
SW1990 GDSC1 8.4145 20.7278 -0.772 19.8851
Hs 766T GDSC1 8.5813 21.2751 -0.9216 20.0638
Capan-2 GDSC1 8.9506 19.584 0.117 15.3756
MIA PaCa-2 GDSC1 9.352 24.4677 -1.9302 21.7382
PaTu 8988t GDSC1 9.4318 26.7773 -2.9853 24.3759
Panc 02.03 GDSC1 9.6574 21.6263 -0.3911 16.0624
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 2.1249 4.3836 1.9072 28.8502
MSTO-211H GDSC1 2.4703 11.6237 -0.9674 38.2234
NCI-H2052 GDSC1 6.0769 8.2252 3.5662 1.8779
NCI-H2452 GDSC1 6.6709 11.8409 2.2931 8.8672
NCI-H28 GDSC1 6.9095 13.7082 1.5704 12.6809
MPP 89 GDSC1 7.004 15.7638 0.6525 17.2407
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 3.0703 8.6515 1.0424 28.6314
VCaP GDSC1 4.3047 5.4608 3.7381 4.6673
22Rv1 GDSC1 4.3761 5.9084 3.5734 5.7106
PC-3 GDSC1 5.5984 10.7872 2.0815 12.9726
DU145 GDSC1 8.1766 16.2706 1.1726 12.0525
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.746 13.4391 1.5908 12.9571
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 792 GDSC1 -1.7986 1.8867 -1.8836 71.1275
G-mel GDSC1 2.1757 4.99 1.7684 29.4099
LB2518-MEL GDSC1 3.0349 7.0174 1.7938 24.5961
COLO 800 GDSC1 3.2347 13.8605 -1.3812 36.101
G-361 GDSC1 3.7925 5.6178 3.1932 11.0234
HT-144 GDSC1 4.2452 5.3731 3.7311 4.945
GAK GDSC1 4.252 13.7681 -0.4595 29.9169
WM35 GDSC1 4.2851 10.2965 1.3039 22.1229
RVH-421 GDSC1 4.4205 15.1959 -1.0331 31.1225
IGR-1 GDSC1 4.4502 5.5701 3.8013 3.6644
CP50-MEL-B GDSC1 4.4743 22.245 -4.5129 37.674
MZ-MEL-2 GDSC1 4.7006 12.5276 0.5302 24.5125
IGR-37 GDSC1 4.7098 6.1657 3.6999 3.6665
SK-MEL-30 GDSC1 4.7651 7.1888 3.239 7.0575
A-431 GDSC1 4.7762 8.326 2.6848 11.2498
WM115 GDSC1 4.9012 8.9497 2.4713 12.4098
SK-MEL-28 GDSC1 4.9323 9.4623 2.241 13.9374
SH-4 GDSC1 4.9932 8.3136 2.8542 9.2989
WM1552C GDSC1 5.0018 6.8862 3.5525 4.0023
COLO 679 GDSC1 5.072 10.3313 1.9171 15.6536
A2058 GDSC1 5.3144 11.1581 1.6916 16.3045
Hs 940.T GDSC1 5.3193 9.7207 2.4019 11.6112
IST-MEL1 GDSC1 5.358 9.0964 2.7333 9.132
RPMI-7951 GDSC1 5.4954 13.0554 0.8905 20.2086
CP66-MEL GDSC1 5.5117 12.9805 0.9398 19.9086
Mel Ho GDSC1 5.6245 9.8991 2.5301 9.8499
SK-MEL-5 GDSC1 5.6968 16.036 -0.4325 25.2831
MZ-MEL-7 GDSC1 5.7869 12.1339 1.5594 15.6822
WM793 GDSC1 5.79 7.8377 3.5842 2.1908
A101D GDSC1 5.8252 7.3023 3.821 0.8531
VMRC-MELG GDSC1 5.8553 11.6196 1.8585 13.6732
MMAc-SF GDSC1 5.8952 10.6872 2.3357 10.4634
SK-MEL-2 GDSC1 5.9033 13.7174 0.8681 19.1119
Mel JuSo GDSC1 5.9363 12.1824 1.6423 14.7672
A-375 GDSC1 6.0173 7.5508 3.8081 0.7367
COLO 783 GDSC1 6.1332 13.4095 1.1849 16.8156
HMV-II GDSC1 6.2529 12.6467 1.6382 13.9311
SK-MEL-24 GDSC1 6.2602 7.7406 3.8362 0.4614
WT2-iPS GDSC1 6.3165 16.7645 -0.3254 23.177
A-388 GDSC1 6.3987 11.9798 2.0547 11.0148
UACC-257 GDSC1 6.4779 18.0468 -0.8371 24.5851
WM278 GDSC1 6.5474 10.7315 2.727 6.331
SK-MEL-1 GDSC1 6.6171 12.609 1.8995 11.4436
M14 GDSC1 6.9053 11.1736 2.7342 5.5943
451Lu GDSC1 7.125 16.7755 0.2481 18.7823
SK-MEL-3 GDSC1 7.1669 15.9809 0.6591 16.8137
DJM-1 GDSC1 7.2003 17.8879 -0.2377 20.6064
COLO 829 GDSC1 7.2687 15.0936 1.1494 14.1324
CHL-1 GDSC1 7.3014 16.8159 0.3498 17.9123
MeWo GDSC1 7.934 23.7073 -2.5502 26.1947
LOX-IMVI GDSC1 8.484 19.9719 -0.3655 18.2428
LB373-MEL-D GDSC1 8.773 20.7046 -0.5231 18.2488
IPC-298 GDSC1 9.7327 24.2399 -1.5692 19.9585
Hs 938.T GDSC1 10.0439 23.5956 -1.0659 17.7767
UACC-62 GDSC1 11.1995 27.1719 -2.0064 18.7693
EquiPSC Line K2 GDSC1 6.6442 16.8543 -0.1301 21.5609
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.8549 8.3243 0.0194 38.8386
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 -1.9619 -0.3622 -1.9622 77.7262
EW-8 GDSC1 2.8826 11.6552 -0.6038 35.5728
Rh41 GDSC1 4.074 9.793 1.3771 22.5239
G-402 GDSC1 4.125 5.8081 3.409 7.9464
SK-LMS-1 GDSC1 4.4258 5.6164 3.7591 4.0764
G-401 GDSC1 4.886 14.3409 -0.2256 26.9832
TE 441.T GDSC1 5.1646 7.7413 3.2533 5.8129
HT-1080 GDSC1 5.3472 13.7561 0.4297 22.8554
SW982 GDSC1 5.7775 7.0394 3.9015 0.5479
A-204 GDSC1 5.9999 12.4832 1.5411 15.1869
SW872 GDSC1 6.5954 18.1407 -0.7964 24.1478
RD GDSC1 6.6306 13.7896 1.3465 14.6194
Rh30 GDSC1 6.7058 15.7797 0.4377 18.9864
KYM-1 GDSC1 6.8446 16.6809 0.0977 20.1187
SK-UT-1 GDSC1 7.0639 8.9959 3.6932 0.4756
MFH-ino GDSC1 7.4667 16.8638 0.4386 17.1269
SW684 GDSC1 7.6115 17.3161 0.3196 17.3248
VA-ES-BJ GDSC1 7.6225 17.2197 0.3729 17.0636
MES-SA GDSC1 7.8184 16.5376 0.8242 14.5307
RKN GDSC1 9.339 19.2302 0.5178 12.9272
GCT GDSC1 9.5088 21.6858 -0.512 16.7883
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 746.T GDSC1 -5.5255 1.1031 -5.7478 85.0818
MKN7 GDSC1 0.9628 16.3928 -4.6994 47.7796
Fu97 GDSC1 3.5614 13.0149 -0.6736 33.0724
GCIY GDSC1 3.9327 11.9672 0.1703 28.8056
ECC10 GDSC1 4.0648 10.0556 1.2381 23.3326
SNU-1 GDSC1 4.4652 10.1078 1.5475 20.0479
OCUM-1 GDSC1 4.5886 13.14 0.1331 26.5893
HSC-39 GDSC1 4.7753 8.1994 2.7469 10.7881
RF-48 GDSC1 4.8086 9.2195 2.2659 14.1726
RERF-GC-1B GDSC1 4.8797 7.6234 3.1098 7.7026
MKN45 GDSC1 4.8963 10.8446 1.526 18.66
MKN1 GDSC1 5.4305 10.7388 1.984 14.1034
SNU-5 GDSC1 5.644 10.2443 2.377 10.8579
IM95 GDSC1 5.8039 12.1668 1.5555 15.6561
NUGC-4 GDSC1 5.8642 11.9468 1.7058 14.5874
23132/87 GDSC1 5.929 12.8964 1.2891 16.8186
TGBC11TKB GDSC1 6.3869 16.7758 -0.2791 22.8138
MKN28 GDSC1 6.9099 15.0835 0.9153 16.1899
NCI-N87 GDSC1 7.1138 8.9935 3.7128 0.4014
TMK-1 GDSC1 7.1484 16.5404 0.3776 18.1547
AGS GDSC1 7.4503 17.7997 -0.0216 19.1482
HGC-27 GDSC1 7.4525 19.4285 -0.8081 22.1186
SCH GDSC1 7.4845 22.4777 -2.2741 26.4468
SNU-16 GDSC1 7.8521 25.5921 -3.5337 28.5929
NUGC-3 GDSC1 8.7082 19.4976 0.0039 16.3214
SNG-M GDSC1 4.1435 9.8558 1.4049 22.0937
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-133 GDSC1 -2.4593 4.7267 -3.1931 68.1828
KMH-2 GDSC1 3.3092 9.7874 0.7053 29.1217
HTC-C3 GDSC1 4.4723 7.6926 2.7602 11.7123
CGTH-W-1 GDSC1 4.6117 11.2426 1.1 22.0353
B-CPAP GDSC1 5.2013 7.5108 3.3872 4.7261
ML-1 [Human leukemia] GDSC1 5.5437 8.6379 3.0774 6.1467
CAL-62 GDSC1 5.6178 7.811 3.5024 3.0103
8505C GDSC1 5.8691 9.8343 2.7238 7.8651
ASH-3 GDSC1 6.0214 7.7175 3.7453 1.0124
8305C GDSC1 6.189 7.5052 3.8936 0.3245
K5 GDSC1 6.2104 8.0989 3.6797 1.1318
WRO GDSC1 7.0598 16.3839 0.3921 18.3054
TT2609-C02 GDSC1 7.55 14.5993 1.5595 11.3031
TT GDSC1 7.7408 17.8942 0.1301 17.85
IHH-4 GDSC1 7.7691 19.4221 -0.5842 20.6009
BHT-101 GDSC1 8.043 18.406 0.0874 17.3627
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 22 GDSC1 -1.2752 0.2846 -1.2757 69.6714
HSC-4 GDSC1 1.8733 6.9 0.6785 36.6182
LB771-HNC GDSC1 3.7679 9.6391 1.1886 24.7966
SCC-9 GDSC1 4.4778 5.7424 3.737 4.0784
SCC-25 GDSC1 4.8421 11.4399 1.1866 20.7704
NCI-H3118 GDSC1 4.8494 10.2349 1.7927 17.1866
BB30-HNC GDSC1 4.886 8.7511 2.5581 11.8289
BHY GDSC1 5.0147 8.0553 2.9964 8.1644
PCI-15A GDSC1 5.2229 9.63 2.3762 12.0796
OSC-19 GDSC1 5.4723 9.5377 2.5994 9.7774
BICR 10 GDSC1 5.6874 7.9833 3.465 3.1273
PCI-04B GDSC1 5.7264 8.1877 3.396 3.5128
HO-1-N-1 GDSC1 5.7833 8.2278 3.4105 3.3085
SCC-15 GDSC1 5.8918 10.5329 2.4073 9.9889
HO-1-u-1 GDSC1 5.9639 11.7305 1.8807 13.2346
BICR 31 GDSC1 6.0796 12.2508 1.7096 13.9691
SCC-4 GDSC1 6.1424 11.2716 2.222 10.5809
PCI-06A GDSC1 6.3282 13.4814 1.2872 15.7305
SAS GDSC1 6.4487 14.5548 0.8513 17.6907
JHU-011 GDSC1 6.5001 10.5126 2.7982 5.9618
JHU-022 GDSC1 6.9604 9.213 3.5729 0.9414
BB49-HNC GDSC1 7.0702 12.0164 2.4519 7.0374
KOSC-2 GDSC1 7.2572 9.3308 3.647 0.5144
DOK GDSC1 7.2695 9.2444 3.6822 0.4152
Detroit 562 GDSC1 7.4863 17.561 0.1178 18.4834
SKN-3 GDSC1 7.6358 17.247 0.3688 17.0516
CAL-33 GDSC1 7.6598 19.134 -0.5206 20.6129
HSC-3 GDSC1 7.7156 15.0573 1.4498 11.5513
OSC-20 GDSC1 7.7969 15.598 1.2497 12.4398
CAL-27 GDSC1 7.8933 23.0156 -2.2416 25.4893
SAT [Human HNSCC] GDSC1 8.0535 10.3154 3.5947 0.3384
BICR 78 GDSC1 8.2099 24.7541 -2.8631 26.3955
PCI-38 GDSC1 8.3181 18.7615 0.0991 16.7272
PCI-30 GDSC1 8.4287 18.0016 0.5266 14.6367
KON GDSC1 8.6843 24.0083 -2.1655 23.6787
Ca9-22 GDSC1 8.8456 20.6698 -0.4594 17.8658
PE/CA-PJ15 GDSC1 9.0153 18.7056 0.5631 13.3236
FaDu GDSC1 9.2641 20.5185 -0.1217 15.7468
HSC-2 GDSC1 10.3973 26.3685 -2.1425 20.4809
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 GDSC1 0.098 2.4432 0.058 52.6694
SW780 GDSC1 1.3613 6.9503 0.1271 41.5408
RT-4 GDSC1 4.7547 8.5579 2.5529 12.2957
639V GDSC1 5.3384 7.0053 3.7027 2.2056
SW1710 GDSC1 5.6363 10.2027 2.3918 10.7774
5637 GDSC1 5.7807 10.7374 2.2335 11.4545
CAL-29 GDSC1 6.0889 8.5862 3.42 2.7202
HT-1197 GDSC1 6.2211 7.9165 3.7549 0.7897
T24 GDSC1 6.6161 12.8344 1.7922 12.0927
J82 GDSC1 6.9205 11.6289 2.5395 6.7847
UM-UC-3 GDSC1 7.0411 15.0709 1.0097 15.3913
RT-112 GDSC1 7.114 14.9861 1.0987 14.7587
BFTC-905 GDSC1 7.2369 15.1773 1.089 14.5197
TCCSUP GDSC1 7.4435 15.5739 1.0362 14.3138
KU-19-19 GDSC1 7.4581 21.5697 -1.8485 25.3598
647V GDSC1 7.8054 17.6882 0.2715 17.0986
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEY GDSC1 -0.9285 0.6659 -0.9295 65.434
JEG-3 GDSC1 0.0164 1.81 0.0081 53.7614
OV17R GDSC1 1.198 8.5288 -0.7335 44.1468
HeLa GDSC1 2.2127 8.935 0.0864 36.7135
C-33 A GDSC1 3.1444 16.2631 -2.6563 38.7914
C-4-I GDSC1 3.3273 14.5627 -1.6492 36.3499
KGN GDSC1 3.6598 5.0306 3.3317 10.5936
BPH-1 GDSC1 3.8502 9.548 1.3061 23.819
NT2-D1 GDSC1 4.2735 5.2633 3.8103 4.2136
ACC-OV7 GDSC1 4.5035 6.1225 3.5681 5.3192
SW954 GDSC1 4.7229 6.6267 3.4842 5.2882
PA-1 GDSC1 4.7845 6.7029 3.4915 5.0516
SiHa GDSC1 5.0142 10.5635 1.7577 16.8563
ME-180 GDSC1 5.1445 10.4627 1.9072 15.4852
OMC-1 [Human cervical carcinoma] GDSC1 5.1458 7.7893 3.2175 6.1302
SKG-IIIa GDSC1 5.1954 9.3694 2.484 11.4009
HT-3 GDSC1 5.3164 9.438 2.5379 10.6585
SKN GDSC1 5.3543 13.0201 0.8004 21.0937
OVMIU GDSC1 5.5668 11.7076 1.6082 16.0383
DoTc2 4510 GDSC1 5.6551 11.7374 1.6581 15.4774
JHOS-3 GDSC1 5.7378 9.8704 2.6205 8.9176
NCC-IT GDSC1 5.9344 7.4659 3.8051 0.8219
OVCA420 GDSC1 6.1793 14.6719 0.6014 19.6305
SW962 GDSC1 6.1833 8.7859 3.3839 2.7909
DSH1 GDSC1 6.2332 15.0272 0.4666 20.1071
PEO1 GDSC1 6.2836 13.2759 1.3556 15.4712
NEC8 GDSC1 6.2879 8.0756 3.7225 0.8693
LB831-BLC GDSC1 6.2974 15.2635 0.3974 20.2454
Ca Ski GDSC1 6.395 21.3452 -2.5298 29.5432
HEC-1 GDSC1 6.4221 13.0848 1.5431 14.0443
SiSo GDSC1 6.4273 8.3938 3.66 1.0166
OVCA433 GDSC1 6.4739 12.0367 2.0768 10.6929
CAL-39 GDSC1 6.6111 13.5941 1.4269 14.2218
UWB1.289 GDSC1 6.702 9.8757 3.1881 3.1643
MS751 GDSC1 6.842 13.6139 1.5709 12.8389
SW756 GDSC1 7.168 24.8867 -3.6956 30.3036
JAR GDSC1 7.7765 22.1414 -1.8987 24.8051
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7932).
2 Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):195-204.
3 Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012 Jul 1;44(8):852-60. doi: 10.1038/ng.2330.