Details of the Drug

General Information of Drug (ID: DMEMQ5J)

• Drug Name: ME-1071
• Synonyms: CP-3242; MBL inhibitor (intravenous, bacterial infection), Meiji Seika Kaisha; Metallo-beta-lactamase inhibitor (intravenous, bacterial infection), Meiji Seika Kaisha

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 1	[1]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 216.14
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 2
  Hydrogen Bond Donor Count; 0
  Hydrogen Bond Acceptor Count; 4
• Chemical Identifiers:
  Formula: C8H10Na2O4
  IUPAC Name: disodium;(Z)-2,3-diethylbut-2-enedioate
  Canonical SMILES: CC/C(=C(\\CC)/C(=O)[O-])/C(=O)[O-].[Na+].[Na+]
  InChI: InChI=1S/C8H12O4.2Na/c1-3-5(7(9)10)6(4-2)8(11)12;;/h3-4H2,1-2H3,(H,9,10)(H,11,12);;/q;2*+1/p-2/b6-5-
  InChIKey: GLJFFZOATODZQQ-XNOMRPDFSA-L
• Cross-matching ID:
  PubChem CID: 16064853
  TTD ID: D0V3BZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027139)
• [2] Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38.