Details of the Drug

General Information of Drug (ID: DMEMQ5J)

Drug Name

ME-1071

Synonyms

CP-3242; MBL inhibitor (intravenous, bacterial infection), Meiji Seika Kaisha; Metallo-beta-lactamase inhibitor (intravenous, bacterial infection), Meiji Seika Kaisha

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 1	[1]
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Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

216.14

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

2

Hydrogen Bond Donor Count

0

Hydrogen Bond Acceptor Count

4

Chemical Identifiers

Formula: C8H10Na2O4
IUPAC Name: disodium;(Z)-2,3-diethylbut-2-enedioate
Canonical SMILES: CC/C(=C(\\CC)/C(=O)[O-])/C(=O)[O-].[Na+].[Na+]
InChI: InChI=1S/C8H12O4.2Na/c1-3-5(7(9)10)6(4-2)8(11)12;;/h3-4H2,1-2H3,(H,9,10)(H,11,12);;/q;2*+1/p-2/b6-5-;;
InChIKey: GLJFFZOATODZQQ-XNOMRPDFSA-L

Cross-matching ID

PubChem CID: 16064853
TTD ID: D0V3BZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027139)
2	Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38.