Details of the Drug

General Information of Drug (ID: DMENF5K)

Drug Name
Liatermin
Synonyms RGDNF; GDNF, Amgen; Glial derived neurotrophic factor, Amgen/Medtronic
Indication
Disease Entry ICD 11 Status REF
Lateral sclerosis 8B61 Phase 1/2 [1]
Cross-matching ID
UNII
PI2EOQ4KE3
DrugBank ID
DB06489
TTD ID
D0IN9G

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glial cell line-derived neurotrophic factor (GDNF) TTF23ML GDNF_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 08 Disease of the nervous system
Disease Class ICD-11: 8A00 Parkinsonism
The Studied Tissue Cervical spinal cord
The Studied Disease Lateral sclerosis [ICD-11:8A00.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glial cell line-derived neurotrophic factor (GDNF) DTT GDNF 2.29E-01 0.08 0.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.