Details of the Drug

General Information of Drug (ID: DMEXMYK)

Drug Name
Alpelisib
Synonyms
alpelisib; 1217486-61-7; BYL-719; BYL719; UNII-08W5N2C97Q; BYL 719; Alpelisib (BYL719); (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; NVP-BYL719; (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide; CHEMBL2396661; 08W5N2C97Q; AK146107; C19H22F3N5O2S; (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
ATC Code
L01EM03: Alpelisib
L01EM: Phosphatidylinositol-3-kinase (Pi3K) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 441.5
Logarithm of the Partition Coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 11,100 +/- 3760 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1320 +/- 912 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2 h [3]
Clearance
The apparent oral clearance of drug is 39.0 L/h [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 8 - 9 hours [4]
Metabolism
The drug is metabolized via the hydrolysis reactions [3]
Vd
The volume of distribution (Vd) of drug is 114 L []
Chemical Identifiers
Formula
C19H22F3N5O2S
IUPAC Name
(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Canonical SMILES
CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
InChI
InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
InChIKey
STUWGJZDJHPWGZ-LBPRGKRZSA-N
Cross-matching ID
PubChem CID
56649450
ChEBI ID
CHEBI:93752
CAS Number
1217486-61-7
UNII
08W5N2C97Q
DrugBank ID
DB12015
TTD ID
D0W7HE
INTEDE ID
DR0074
ACDINA ID
D00827
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase alpha (PIK3CA) TTEUNMR PK3CA_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Breast tissue
The Studied Disease Breast cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase alpha (PIK3CA) DTT PIK3CA 1.59E-38 -0.65 -1.11
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.87E-03 -6.67E-02 -2.12E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.2148 6.5221 0.9114 6.6339
HuO9 GDSC2 1.4385 6.2404 -0.4147 19.7376
ES5 GDSC2 1.4754 7.7167 -0.5553 26.6963
EW-7 GDSC2 1.4808 5.8311 -0.175 18.2404
EW-12 GDSC2 1.4974 5.004 0.7102 22.6441
EW-11 GDSC2 1.7994 7.7623 -0.845 20.7975
ES1 GDSC2 1.9643 12.0766 -2.8566 28.4437
SK-N-MC CTRP2 2.2207 7.7946 1.2903 28.6515
EW-3 GDSC2 2.2302 8.6965 -0.9421 19.9207
G-292 clone A141B1 GDSC2; CTRP2 2.413 7.7559 1.5108 27.3256
ES6 GDSC2 2.4485 7.2619 -0.0434 14.3933
EW-24 GDSC2 2.5141 6.5862 0.3477 11.8748
EW-22 GDSC2 2.5669 7.7282 -0.1799 14.8392
EW-1 GDSC2 2.6893 6.4306 0.5651 10.0603
TC71 CTRP2 2.701 5.7171 2.4796 23.0395
EW-18 GDSC2 2.7438 6.4303 0.6079 9.6516
SK-ES-1 GDSC2; CTRP2 2.9188 7.5893 2.115 23.6996
NOS-1 [Human HNSCC] GDSC2 2.9337 8.0364 -0.0428 13.0418
CAL-72 GDSC2 3.088 6.5973 0.7842 7.7031
CHSA8926 GDSC2 3.0918 6.6113 0.7801 7.7186
EW-16 GDSC2 3.3103 9.1768 -0.3207 13.6294
ES8 GDSC2 3.3666 7.6471 0.4718 8.935
ES7 GDSC2 3.434 5.9843 1.3138 3.781
H-EMC-SS GDSC2 3.4368 8.3449 0.1814 10.4781
CHSA0011 GDSC2 3.4589 8.9482 0.6221 16.2642
TC-71 GDSC2 3.5427 5.6759 1.5199 2.4381
A-673 GDSC2; CTRP2 3.5539 8.1633 2.5546 20.278
MHH-ES-1 GDSC2 3.8899 7.1512 1.8576 7.0335
ES4 GDSC2 3.9291 6.7631 1.2546 3.2706
SK-PN-DW GDSC2 3.982 7.6157 0.8974 5.1672
CHSA0108 GDSC2 4.1439 18.3954 -3.5413 29.8247
SaOS-2 GDSC2; CTRP2 4.175 11.3602 1.7037 21.8177
EW-13 GDSC2 4.2237 7.7604 0.9765 4.3121
HuO-3N1 GDSC2 4.5461 6.6833 1.5995 0.9445
NY GDSC2 4.5872 6.7571 1.5888 0.9526
CADO-ES1 GDSC2 4.6154 6.2697 1.7824 0.3509
Hs 888.T CTRP2 5.0984 10.8077 2.8348 15.3584
U2OS GDSC2 5.121 10.3221 1.1838 8.1846
U-CH2 GDSC2 5.244 12.4224 0.257 13.6283
MG-63 GDSC2; CTRP2 5.272 14.2525 1.2801 20.7452
SJSA-1 GDSC2; CTRP2 5.9366 10.3428 3.8047 9.6164
Hs 822.T CTRP2 6.2656 9.1383 4.6777 5.3317
CAL-78 GDSC2; CTRP2 6.3191 10.4327 4.0747 7.7606
HOS GDSC2; CTRP2 6.6782 10.1968 4.4699 5.4904
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 205 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 4.8962 8.1189 3.9438 11.3273
JM1 GDSC2; CTRP2 6.0186 12.8186 2.6358 14.2151
NCI-H929 GDSC2 -1.3468 2.1962 -1.6482 38.0761
SUP-B8 GDSC2 0.2068 4.0533 -0.3023 33.6523
KMS-34 CTRP2 0.3218 2.6182 0.3131 38.1529
SU-DHL-6 GDSC2 0.4115 1.8816 0.3386 19.5471
A4/Fukuda GDSC2; CTRP2 0.7079 5.78 0.2905 36.7745
MM1.S GDSC2; CTRP2 0.9501 3.5909 0.9159 34.0518
KY821 GDSC2 1.0609 5.2198 -0.2767 20.3375
KMS-20 CTRP2 1.3225 7.824 0.3153 34.4971
LP-1 GDSC2; CTRP2 1.4812 5.7544 1.1405 31.5251
OCI-Ly7 GDSC2 1.507 8.6244 -0.9606 30.3724
Hs 611.T CTRP2 1.5259 8.6103 0.2347 34.0176
NALM-6 GDSC2 1.557 6.654 -0.5105 19.8516
KMS-11 GDSC2; CTRP2 1.5826 10.3684 -0.4326 35.4351
Kasumi-1 GDSC2; CTRP2 1.659 5.3845 1.4211 30.0149
MOLP-8 GDSC2; CTRP2 1.6712 6.9379 1.001 31.3354
Pfeiffer CTRP2 1.7712 7.9214 0.7612 31.7364
MOLM-16 GDSC2 1.843 4.3973 1.3257 17.7157
SU-DHL-16 GDSC2 1.8444 4.9207 1.1046 18.9908
WSU-NHL GDSC2 1.8596 4.5498 0.8026 11.0486
BONNA-12 GDSC2 1.8635 7.6134 -0.1342 25.5287
EB1 CTRP2 1.884 8.2915 0.7403 31.4332
HAL-01 GDSC2 1.9445 6.2879 0.0162 15.5795
KMS-12-BM GDSC2; CTRP2 1.9701 6.3877 1.4997 28.7437
GA-10 GDSC2; CTRP2 2.0548 6.6304 1.5174 28.415
Kasumi-2 CTRP2 2.0622 10.6371 -0.0563 33.0362
BL-70 CTRP2 2.1085 3.2468 2.108 26.2231
EoL-1 GDSC2; CTRP2 2.1214 5.3386 1.9331 26.7782
RPMI-8402 GDSC2 2.136 6.9625 -0.1551 15.977
ATN-1 GDSC2 2.1539 5.9756 0.3532 12.8996
KMS-18 CTRP2 2.2066 5.6763 1.9506 26.4462
MOLT-3 CTRP2 2.231 6.3305 1.8012 26.8887
YT GDSC2 2.4622 3.8813 1.6559 3.8266
MOLT-16 GDSC2; CTRP2 2.4945 5.0399 2.3911 24.0016
Namalwa GDSC2; CTRP2 2.5354 7.0418 1.9026 25.5973
OPM-2 GDSC2; CTRP2 2.5448 5.8135 2.2856 24.2115
ARH-77 GDSC2 2.5534 4.9693 1.1858 6.5468
MLMA GDSC2 2.5646 9.4491 -1.0415 19.4135
JVM-3 GDSC2 2.5712 8.7439 -0.6837 17.5842
U-698-M GDSC2 2.5739 4.976 1.1986 6.412
KMS-28BM CTRP2 2.6164 12.0781 -0.1525 31.6344
SU-DHL-5 GDSC2 2.6172 5.9607 0.7424 9.157
Jurkat GDSC2 2.634 5.0322 1.2173 6.1369
DoHH2 GDSC2 2.6611 3.5554 2.5258 6.6951
JVM-2 GDSC2 2.6776 6.7783 0.3827 11.2082
ALL-PO GDSC2 2.6791 6.7808 0.3827 11.204
Karpas-1106P GDSC2 2.6944 6.9656 0.3027 11.6467
P32/ISH GDSC2 2.7188 4.8369 1.3779 4.9171
ML-2 GDSC2 2.7796 6.5605 0.571 9.7845
KE-37 GDSC2 2.7919 5.0181 1.3426 4.9603
OCI-Ly19 GDSC2; CTRP2 2.7949 10.9742 0.5342 29.2743
GR-ST GDSC2 2.8347 5.5479 1.1138 6.2788
Farage GDSC2 2.836 4.5984 2.2443 7.6166
RCH-ACV GDSC2; CTRP2 2.8376 7.1174 2.2025 23.6213
MOLM-13 GDSC2 2.8387 4.7069 1.5278 3.7095
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 2.844 9.6824 1.1648 27.1993
MV4-11 GDSC2 2.8658 8.1226 -0.1386 13.7722
RPMI-8866 GDSC2 2.8739 5.0197 1.4008 4.4094
VL51 GDSC2 2.8805 7.4246 0.2198 11.6438
THP-1 GDSC2; CTRP2 2.8833 6.8105 2.3586 22.9195
P31/FUJ GDSC2 2.8908 5.9487 0.9581 7.1082
HPB-ALL CTRP2 2.8972 5.5512 2.7307 21.5403
CESS GDSC2 2.902 5.0243 1.4183 4.2384
MHH-CALL-2 GDSC2 2.9366 5.7472 1.0907 6.1769
SUP-T1 GDSC2; CTRP2 2.9591 8.6114 1.7455 24.9042
P30/OHK GDSC2 2.9624 6.7504 0.6162 9.0382
Loucy GDSC2 2.9704 5.2518 1.3559 4.4678
PF-382 GDSC2 3.0062 6.01 1.0124 6.4956
Mono-Mac-6 GDSC2; CTRP2 3.02 14.6371 -0.9747 32.4383
P12-Ichikawa GDSC2 3.0413 5.3609 1.3521 4.3367
L-363 GDSC2; CTRP2 3.0681 7.3089 2.3806 22.2962
L-1236 GDSC2 3.0878 6.6797 0.7437 7.9508
WSU-DLCL2 GDSC2 3.1327 6.4024 0.9116 6.8195
CCRF-CEM GDSC2 3.1608 5.3938 1.4162 3.705
BC-1 GDSC2 3.1769 6.7772 0.7604 7.6387
EB2 GDSC2 3.178 6.5848 0.8549 7.0609
MHH-CALL-4 GDSC2 3.2062 8.4712 0.6503 16.8637
CML-T1 GDSC2 3.2631 7.7664 0.3387 9.9707
697 GDSC2; CTRP2 3.28 7.4442 2.5562 21.037
SUP-HD1 GDSC2; CTRP2 3.3726 7.3061 2.7079 20.2062
BALL-1 GDSC2 3.375 6.6107 0.979 5.8763
HH [Human lymphoma] GDSC2 3.4245 6.8164 0.9138 6.1615
Karpas-45 GDSC2 3.4311 5.1554 1.6879 1.7151
PL-21 GDSC2 3.4458 9.8151 0.1779 18.6665
ALL-SIL GDSC2 3.463 5.8502 1.3937 3.2703
HuT 78 CTRP2 3.47 9.4453 1.9079 22.9052
NK-92MI GDSC2 3.4917 5.6507 2.2958 6.0195
RS4;11 GDSC2; CTRP2 3.517 8.929 2.1858 21.7612
GDM-1 GDSC2; CTRP2 3.5756 8.5982 2.3909 20.8366
CRO-AP2 GDSC2 3.6244 8.3692 1.0458 13.37
U-937 CTRP2 3.6371 5.8897 3.4579 16.6607
HT GDSC2 3.6929 11.4648 -0.4446 20.9304
AMO1 GDSC2; CTRP2 3.7178 7.4092 3.0358 17.9948
Reh GDSC2; CTRP2 3.7334 7.5578 2.993 18.1151
HL-60 GDSC2; CTRP2 3.7707 9.2469 2.3013 20.6535
Karpas-231 GDSC2 3.7878 5.0902 1.8866 0.4817
HC-1 GDSC2 3.8003 6.515 1.2916 3.2731
NU-DUL-1 GDSC2; CTRP2 3.8229 7.2312 3.2173 17.0102
KM-H2 GDSC2 3.8263 6.9427 1.1123 4.2276
PL21 CTRP2 3.8395 8.3227 2.7825 18.6358
EJM GDSC2; CTRP2 3.8446 14.0574 0.0838 27.7431
HEL GDSC2 3.8585 5.9791 2.4096 3.9901
BL-41 GDSC2 3.8827 5.426 1.798 0.7253
KCL-22 GDSC2 3.8851 5.8172 1.6411 1.3781
TK [Human B-cell lymphoma] GDSC2 3.899 5.7096 1.6921 1.138
Hs 445 GDSC2 3.9185 5.921 1.6144 1.4629
SU-DHL-10 GDSC2 3.9262 5.2412 1.887 0.3979
VAL GDSC2 3.9434 6.4076 1.4197 2.3801
DEL GDSC2 3.9458 5.2343 1.8974 0.3579
CTB-1 GDSC2 4.0012 10.4551 0.3044 16.4434
OCI-AML-3 GDSC2; CTRP2 4.0105 8.3402 2.9504 17.5324
EM-2 GDSC2 4.0108 5.906 1.6653 1.1427
BC-3 GDSC2 4.0541 7.9724 1.5751 9.0606
LAMA-84 GDSC2 4.0578 6.3736 1.4945 1.8628
KOPN-8 GDSC2 4.0685 6.5186 1.4383 2.1217
MOLT-4 GDSC2 4.0758 5.6062 1.8116 0.5419
Ku812 GDSC2 4.0964 6.0663 1.6406 1.1644
TUR GDSC2 4.1099 5.4979 1.8657 0.3633
H9 GDSC2 4.1162 8.5084 0.5657 6.8013
WIL2 NS GDSC2 4.16 5.6585 1.8265 0.4473
NB4 GDSC2; CTRP2 4.1706 9.9779 2.3594 19.4087
SCC-3 GDSC2 4.1757 5.5337 1.8783 0.3015
JSC-1 GDSC2 4.1918 6.6928 1.4279 2.0196
IM-9 GDSC2 4.2257 5.7204 1.83 0.4036
SU-DHL-1 GDSC2 4.2494 15.6845 -2.1044 25.6803
Karpas-422 GDSC2; CTRP2 4.313 8.4536 3.2074 15.739
Ramos.2G6.4C10 GDSC2 4.3255 5.7918 1.843 0.3247
ST486 GDSC2; CTRP2 4.3285 6.9459 3.8666 13.1182
Daudi GDSC2; CTRP2 4.3297 6.664 3.9736 12.7084
RC-K8 GDSC2 4.3304 5.9258 1.7962 0.4445
NOMO-1 GDSC2; CTRP2 4.3415 10.2279 2.4064 18.8068
QIMR-WIL GDSC2 4.3467 7.8827 1.8288 6.8395
MY-M12 GDSC2 4.3487 8.8686 1.3508 9.6948
CTV-1 GDSC2 4.3877 6.4015 1.6398 0.9181
MHH-CALL-3 CTRP2 4.3959 7.3055 3.7936 13.2148
AML-193 CTRP2 4.4132 7.78 3.6093 13.8907
DG-75 GDSC2 4.4544 6.594 1.5939 1.0368
MC116 GDSC2; CTRP2 4.5005 6.502 4.2156 11.3085
OCI-AML-5 GDSC2; CTRP2 4.5157 8.4529 3.4113 14.4149
Jiyoye GDSC2 4.5221 6.5812 1.6286 0.8585
Granta-519 GDSC2; CTRP2 4.5353 11.5288 1.9615 20.0127
JeKo-1 GDSC2; CTRP2 4.58 9.7798 2.8501 16.4975
KMOE-2 GDSC2 4.601 6.4772 1.701 0.5743
MHH-PREB-1 GDSC2 4.6069 6.1257 1.8302 0.2499
RPMI-8226 GDSC2; CTRP2 4.6379 8.4165 3.5498 13.5547
Mono-Mac-1 CTRP2 4.6592 7.2334 4.0991 11.315
SUP-M2 GDSC2; CTRP2 4.6768 7.4349 4.0309 11.5362
DND-41 GDSC2 4.692 6.5503 1.7104 0.5
ME1 GDSC2 4.6927 6.2461 1.8196 0.2438
JURL-MK1 GDSC2 4.7195 6.772 1.6392 0.6936
SUP-T11 CTRP2 4.7496 8.801 3.4799 13.5625
MN-60 GDSC2 4.7524 6.6539 1.6964 0.5085
MEG-01 GDSC2 4.7612 6.5718 1.7297 0.4177
Karpas-620 GDSC2; CTRP2 4.9374 7.2976 4.3589 9.5583
RPMI-6666 GDSC2; CTRP2 4.9666 8.6209 3.7759 11.8395
L-540 GDSC2; CTRP2 4.9919 7.6285 4.2654 9.7925
BE-13 GDSC2 5.015 6.979 1.6807 0.4304
LC4-1 GDSC2 5.0164 7.1044 1.6358 0.5438
OCI-Ly10 CTRP2 5.0354 16.8249 -0.2082 25.7588
SET-2 CTRP2 5.0452 9.5085 3.4226 13.1
CA46 GDSC2; CTRP2 5.0535 8.4508 3.9408 10.9596
OCI-Ly3 CTRP2 5.078 13.9237 1.273 21.1953
HDLM-2 GDSC2 5.1343 6.9122 1.7486 0.2475
NU-DHL-1 CTRP2 5.1346 9.4638 3.5278 12.4656
SK-MM-2 GDSC2; CTRP2 5.1632 8.4696 4.0371 10.3071
KG-1 GDSC2 5.2447 7.1582 1.7032 0.2996
SEM CTRP2 5.3085 10.5849 3.1351 13.6857
NKM-1 GDSC2 5.3808 7.5048 1.6317 0.4013
JJN-3 GDSC2; CTRP2 5.4451 7.5299 4.7578 6.6881
ROS-50 GDSC2 5.4671 10.629 1.264 7.8182
REC-1 CTRP2 5.4913 7.7288 4.7062 6.7923
OCI-AML-2 GDSC2; CTRP2 5.5664 11.0735 3.1212 13.1914
DB GDSC2; CTRP2 5.593 6.8418 5.2271 4.419
BV-173 GDSC2; CTRP2 5.6383 8.4458 4.4905 7.3599
L-428 GDSC2; CTRP2 5.7393 8.3412 4.6328 6.5501
M-07e CTRP2 5.8351 11.7302 3.0253 13.0285
SU-DHL-4 GDSC2; CTRP2 5.8503 7.9951 4.9029 5.1865
MOLM-6 CTRP2 5.8683 7.5177 5.1563 4.0872
MOTN-1 CTRP2 5.8946 8.2872 4.7958 5.5446
HD-MY-Z CTRP2 5.8948 7.3433 5.2664 3.5707
SUP-B15 GDSC2; CTRP2 5.8974 10.381 3.7524 9.9122
SU-DHL-8 GDSC2; CTRP2 5.9507 6.9049 5.5338 2.3344
TF-1 CTRP2 6.0834 7.2819 5.4578 2.3913
SIG-M5 GDSC2; CTRP2 6.1005 7.4471 5.3892 2.6477
CMK CTRP2 6.1303 6.9417 5.6651 1.436
A3/Kawakami GDSC2; CTRP2 6.1741 7.2689 5.5366 1.8971
RL GDSC2; CTRP2 6.1813 9.8857 4.2366 7.3374
Ci-1 CTRP2 6.1839 7.2575 5.5498 1.825
K-562 GDSC2; CTRP2 6.2302 7.4194 5.505 1.9331
U266B1 GDSC2; CTRP2 6.2729 12.5385 2.9858 12.3316
KO52 CTRP2 6.3691 10.3167 4.1725 7.2612
Toledo CTRP2 6.4299 10.7116 4.0238 7.7729
MOLP-2 CTRP2 6.4669 12.5725 3.1254 11.4063
F-36P CTRP2 6.4672 15.7581 1.5353 17.4301
SR GDSC2; CTRP2 6.4905 7.9228 5.4459 1.7737
MOLT-13 GDSC2; CTRP2 6.6193 10.7812 4.1364 6.9734
KYO-1 CTRP2 6.7377 8.1417 5.5017 1.2392
HEL 92.1.7 CTRP2 7.004 8.6484 5.4285 1.2206
OCI-M1 GDSC2; CTRP2 7.2669 8.5572 5.6018 0.4598
SKM-1 GDSC2; CTRP2 7.4857 11.1802 4.5554 3.9617
Karpas-299 GDSC2; CTRP2 7.6095 12.4014 4.0567 5.7661
ME1 CTRP2 7.949 13.7411 3.6443 6.9217
Raji GDSC2; CTRP2 7.9581 12.9009 4.0497 5.3222
P3HR-1 CTRP2 10.7215 29.3423 -1.9743 20.401
⏷ Show the Full List of 205 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 4.0595 11.9028 1.3322 23.3924
TE8 CTRP2 5.1584 11.0357 2.7768 15.456
TE-5 GDSC2; CTRP2 2.1872 7.1218 1.4983 28.0634
T.T GDSC2 2.2874 5.1735 0.8673 9.3038
KYSE-410 GDSC2; CTRP2 2.5367 6.6215 2.0446 25.0908
KYSE-270 GDSC2 2.8427 5.5898 1.0991 6.3506
KYSE-70 GDSC2; CTRP2 2.8498 7.2579 2.165 23.7208
OE21 GDSC2 3.1211 5.8105 1.1904 5.1455
TE-15 GDSC2 3.1882 7.7399 0.2967 10.4024
TE-11 GDSC2; CTRP2 3.2582 7.8641 2.3676 21.8007
TE-9 GDSC2 3.2886 5.8727 1.273 4.2993
KYSE-140 GDSC2 3.2959 6.5098 0.9736 6.0782
EC-GI-10 GDSC2; CTRP2 3.4083 8.1804 2.3954 21.2775
TE-4 GDSC2; CTRP2 3.4438 6.218 3.157 18.3345
TE-6 GDSC2; CTRP2 3.4728 7.8749 2.5895 20.3695
TE-14 CTRP2 3.5198 7.8695 2.6411 20.0444
TE-10 GDSC2 3.6759 9.7551 0.3954 16.8671
TE-8 GDSC2 3.7892 8.7549 0.2309 9.3886
KYSE-180 GDSC2 3.8369 6.4125 1.3586 2.8535
COLO 680N GDSC2 4.2669 11.6248 -0.8252 13.9861
OE33 GDSC2; CTRP2 4.9729 15.1104 0.5901 23.6189
KYSE-150 GDSC2; CTRP2 5.0066 9.421 3.4288 13.1636
KYSE-520 GDSC2; CTRP2 5.1084 10.095 3.1945 13.8865
KYSE-30 CTRP2 5.2878 12.2505 2.2903 17.0701
KYSE-510 GDSC2; CTRP2 5.3726 13.4119 1.7869 18.7568
TE-1 GDSC2; CTRP2 5.8315 10.5383 3.6176 10.6049
KYSE-450 GDSC2; CTRP2 7.0472 12.4549 3.6316 8.3382
OE19 GDSC2; CTRP2 8.1027 15.3731 2.9641 9.3467
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 5.4455 11.8243 2.6414 15.3689
PaTu 8988s CTRP2 1.8539 9.628 0.1648 33.1271
BxPC-3 GDSC2 2.9362 5.6645 1.1308 5.9301
HuP-T4 GDSC2; CTRP2 3.2092 7.5491 2.4401 21.6706
Panc 08.13 GDSC2; CTRP2 3.4297 9.4342 1.872 23.1437
PL4 GDSC2 3.4838 8.2324 0.2701 9.8516
CFPAC-1 GDSC2 3.7191 7.5624 0.7546 6.4944
HPAF-II GDSC2 3.7664 6.416 1.3166 3.191
SUIT-2 GDSC2 3.8501 5.4487 1.7744 0.8431
Panc 05.04 CTRP2 4.0638 8.8923 2.7574 18.145
DAN-G GDSC2; CTRP2 4.2669 7.9773 3.3728 15.2057
KP-4 GDSC2 4.3776 5.7411 1.8806 0.2228
KP-1N GDSC2 4.4278 7.4038 1.2471 2.603
L3.3 CTRP2 4.4962 9.2708 3.0108 16.0624
KP-3 GDSC2 4.5174 6.935 1.4869 1.4075
AsPC-1 GDSC2; CTRP2 4.5385 9.8181 2.7918 16.8276
QGP-1 GDSC2 4.595 10.0244 0.9633 10.3964
PK-59 CTRP2 4.6001 8.353 3.5414 13.6828
Capan-1 GDSC2; CTRP2 4.7054 10.2294 2.7529 16.5843
Panc 10.05 GDSC2; CTRP2 4.7931 9.9158 2.9876 15.4447
TCC-Pan2 CTRP2 4.842 9.7467 3.1156 14.8158
PANC-1 CTRP2 4.9518 9.0298 3.5658 12.7316
YAPC GDSC2; CTRP2 4.962 9.8534 3.1767 14.2914
MZ-PC-1 GDSC2 4.9918 7.9616 2.2016 3.4586
HPAC GDSC2; CTRP2 5.0989 8.6149 3.9058 10.996
SW1990 GDSC2; CTRP2 5.2656 8.1225 4.3017 8.981
MIA PaCa-2 GDSC2; CTRP2 5.334 9.6669 3.6117 11.6754
Panc 02.03 GDSC2; CTRP2 5.3576 10.4218 3.26 13.07
Capan-2 GDSC2; CTRP2 5.5454 12.0637 2.6094 15.2836
Panc 03.27 GDSC2; CTRP2 5.8158 11.9244 2.9118 13.5248
SU.86.86 GDSC2; CTRP2 5.9598 9.1738 4.4087 7.0399
Panc 04.03 GDSC2; CTRP2 5.9997 7.7164 5.1709 3.7589
SNU-410 CTRP2 6.1912 10.4386 3.9684 8.4416
KP-2 GDSC2; CTRP2 6.3088 10.1424 4.2114 7.2078
PaTu 8902 GDSC2; CTRP2 6.4199 10.2247 4.2583 6.8118
Hs 766T GDSC2; CTRP2 6.4261 11.1834 3.7857 8.7709
PaTu 8988t GDSC2; CTRP2 6.5421 8.3489 5.2759 2.3867
PK-45H CTRP2 6.6172 16.2201 1.4256 17.5246
HuP-T3 GDSC2; CTRP2 6.9642 14.3125 2.6497 12.4002
PSN1 GDSC2; CTRP2 7.2176 14.3331 2.8325 11.2534
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 75 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 5.139 18.2725 -0.8397 27.1388
A-388 GDSC2 0.5509 4.4855 -0.0841 30.9543
A-431 GDSC2 1.0183 6.4252 -0.4065 30.213
VMRC-MELG GDSC2 2.1323 8.8285 -0.4763 26.0748
Hs 852.T CTRP2 3.2423 9.2114 1.7801 23.9851
WM1552C GDSC2 3.2992 5.9539 1.2415 4.465
RPMI-7951 GDSC2 3.4576 7.393 0.6591 7.6119
Hs 938.T GDSC2 3.498 6.6203 1.8171 9.0166
COLO 783 GDSC2 3.5224 13.9604 -1.8312 26.7451
WM115 GDSC2; CTRP2 3.5387 6.284 3.2408 17.7443
DJM-1 GDSC2 3.6014 9.5726 0.4264 16.915
COLO 792 GDSC2; CTRP2 3.6717 9.406 2.1294 21.5562
IST-MEL1 GDSC2 3.7124 5.9278 1.5035 2.2722
MZ-MEL-2 GDSC2 3.7275 7.813 1.4048 10.9385
WM35 GDSC2 3.9286 8.9878 0.2142 9.182
M14 GDSC2 4.1011 6.2236 1.5786 1.4266
SK-MEL-1 GDSC2 4.1109 5.3014 1.9365 0.1966
LB373-MEL-D GDSC2 4.1582 8.4787 1.403 9.8431
CP66-MEL GDSC2 4.1876 7.618 1.8456 6.4547
MMAc-SF GDSC2 4.2109 9.1429 1.115 11.4135
HMV-II GDSC2 4.3064 12.3915 -1.1701 15.5559
GAK GDSC2 4.3386 5.8438 1.8293 0.3529
COLO 679 GDSC2 4.3504 6.1371 1.7254 0.6472
WM88 CTRP2 4.3598 6.4597 4.0778 12.2315
Malme-3M CTRP2 4.4979 16.1846 -0.3659 27.3738
LB2518-MEL GDSC2 4.536 10.6548 0.6115 13.4376
CP50-MEL-B GDSC2 4.6005 13.6904 -0.8391 20.2006
WM266-4 CTRP2 4.6207 7.6105 3.8967 12.213
G-361 GDSC2; CTRP2 4.6557 8.2116 3.6619 13.0599
CHL-1 GDSC2 4.7647 6.733 1.6722 0.5697
SH-4 GDSC2 4.8763 6.8714 1.6657 0.5311
Hs 895.T CTRP2 4.8892 10.0909 2.9929 15.1998
WM278 GDSC2 5.1394 8.0675 1.3201 1.5233
451Lu GDSC2 5.1791 7.4205 2.5354 1.5363
Hs 940.T GDSC2; CTRP2 5.2632 9.6799 3.5406 12.1247
A-375 GDSC2; CTRP2 5.2871 10.8397 2.9897 14.321
MZ-MEL-7 GDSC2 5.5723 7.3022 2.754 0.4406
G-mel GDSC2 5.6148 11.142 1.1176 7.6331
HT-144 GDSC2; CTRP2 5.7353 8.5784 4.5114 7.0661
Mel Ho GDSC2 5.972 13.195 0.3808 11.476
SK-MEL-24 GDSC2; CTRP2 6.0262 9.9574 4.0727 8.3202
SK-MEL-3 GDSC2; CTRP2 6.029 9.4249 4.3413 7.1879
Hs 294T CTRP2 6.0409 12.6268 2.7502 13.7201
CJM [Human melanoma] CTRP2 6.0436 9.0671 4.5324 6.3569
Hs 944.T CTRP2 6.0498 11.7992 3.1714 12.0096
WM983B CTRP2 6.1075 11.657 3.2904 11.4116
MeWo GDSC2; CTRP2 6.1184 10.7463 3.7548 9.4712
Hs 688(A).T CTRP2 6.1302 11.3556 3.46 10.6711
IGR-39 CTRP2 6.2012 10.946 3.723 9.4463
SK-MEL-5 GDSC2; CTRP2 6.241 7.5261 5.4603 2.1006
COLO 800 GDSC2; CTRP2 6.2848 10.004 4.2612 7.043
HMCB CTRP2 6.3542 7.7043 5.4563 1.9342
RVH-421 GDSC2; CTRP2 6.3816 9.1391 4.7683 4.7472
IPC-298 GDSC2; CTRP2 6.3875 9.1728 4.7562 4.7878
SK-MEL-2 GDSC2; CTRP2 6.4057 7.6959 5.497 1.6901
MDA-MB-435S CTRP2 6.4347 13.6313 2.5711 13.6663
WM1799 CTRP2 6.442 12.1845 3.299 10.7471
COLO 829 GDSC2; CTRP2 6.4733 9.1845 4.8159 4.3928
SK-MEL-31 GDSC2; CTRP2 6.4764 12.5598 3.1393 11.3329
A101D GDSC2; CTRP2 6.5624 8.0354 5.4405 1.6956
SK-MEL-30 GDSC2; CTRP2 6.5707 7.9364 5.4928 1.4776
WT2-iPS GDSC2; CTRP2 6.6273 10.5841 4.2401 6.5287
SK-MEL-28 GDSC2; CTRP2 6.6356 10.9749 4.0529 7.2923
IGR-1 GDSC2; CTRP2 6.7661 11.9185 3.685 8.5898
WM793 GDSC2; CTRP2 6.7709 12.9831 3.1603 10.7191
UACC-62 GDSC2; CTRP2 6.8218 10.5029 4.4252 5.4435
A2058 GDSC2; CTRP2 6.8405 8.198 5.5363 1.0022
IGR-37 GDSC2; CTRP2 6.8675 10.2971 4.5589 4.8228
UACC-257 GDSC2; CTRP2 7.1518 11.9318 3.9648 6.8129
Hs 839.T CTRP2 7.2329 13.2754 3.3652 9.1142
LOX-IMVI GDSC2; CTRP2 7.2906 14.463 2.8231 11.1678
Mel JuSo GDSC2; CTRP2 8.2146 14.9511 3.2441 8.107
K029AX CTRP2 8.3725 14.9719 3.34 7.5191
Hs 936.T CTRP2 10.7178 22.4129 1.3501 11.4569
EquiPSC Line K2 GDSC2 5.3811 13.5827 -0.2101 15.5737
⏷ Show the Full List of 75 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC2 1.829 6.7144 -0.2975 17.7631
KYSE-220 GDSC2 2.6641 6.0043 0.7576 8.9363
TE-12 GDSC2 3.0254 8.7882 0.3379 17.5642
KYAE-1 GDSC2 3.0791 6.5391 0.8063 7.5889
SK-GT-4 GDSC2 3.1556 9.5052 -0.6008 15.5359
ESO-26 GDSC2 3.2459 5.5114 1.4158 3.541
FLO-1 GDSC2 3.7273 6.838 1.1 4.4739
OACM5.1 C GDSC2 4.2881 9.9082 0.0158 9.5362
KYSE-50 GDSC2 4.3011 6.2732 1.6517 0.9418
HCE-4 GDSC2 4.4989 7.9923 1.8798 6.208
ESO-51 GDSC2 4.648 6.4151 1.7425 0.4356
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2; CTRP2 3.2057 9.2922 1.707 24.3445
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC2 0.1371 4.012 -0.6689 26.2137
NB69 GDSC2 1.0434 7.7941 -1.5412 26.6763
CHP-212 GDSC2; CTRP2 1.3811 6.4948 0.8255 32.8476
NB(TU)1 GDSC2 2.6282 8.9467 -0.7388 17.7069
SJNB-6 GDSC2 2.7776 5.9465 1.5323 12.9983
KP-N-YS GDSC2 2.8331 8.94 0.0958 20.9862
SK-N-FI GDSC2 2.8443 12.1499 -2.1638 23.4884
NH-12 GDSC2 3.0928 7.292 0.4464 9.7435
SK-N-BE(2)-M17 GDSC2 3.1362 5.572 1.3152 4.3585
SJNB-13 GDSC2 3.2893 5.9564 1.2339 4.5303
NB1 GDSC2; CTRP2 3.386 7.6917 2.5719 20.6781
NH-6 CTRP2 3.4849 10.2517 1.5553 24.1129
KP-N-RT-BM-1 GDSC2 3.4989 6.23 2.0126 7.7861
TGW GDSC2 3.5642 8.4168 0.2375 9.8561
SJNB-10 GDSC2 3.5988 9.829 -0.4279 13.4969
LA-N-6 GDSC2 3.7032 11.1997 -0.3039 20.2606
SiMa GDSC2 3.803 6.0208 1.5122 2.1011
GI-ME-N GDSC2 3.8212 10.6401 -0.6635 14.1988
CHP-134 GDSC2 3.9361 5.5814 1.7607 0.8235
SJNB-17 GDSC2 3.9477 7.5864 1.6861 8.6467
MHH-NB-11 GDSC2 3.9612 8.1704 1.4077 10.3081
SK-N-SH GDSC2; CTRP2 4.1167 12.4923 1.1005 24.0194
KP-N-SI9s CTRP2 4.2433 12.5302 1.2006 23.3798
SK-N-MC-IXC GDSC2 4.2857 14.0353 -1.2543 22.6506
SJNB-14 GDSC2 4.3456 6.021 1.767 0.5204
SJNB-7 GDSC2 4.4738 6.342 1.6994 0.6535
GOTO GDSC2 4.5392 6.8601 1.5269 1.2255
IMR-5 GDSC2 4.8373 6.5123 1.7796 0.2772
SK-N-DZ GDSC2; CTRP2 5.1809 12.5879 2.0278 18.2917
SK-N-BE(2) CTRP2 5.2497 11.7282 2.5158 16.2829
SJNB-5 GDSC2 5.2733 13.2124 -0.1065 15.3323
KP-N-YN GDSC2; CTRP2 5.6744 9.1679 4.1645 8.6452
CHP-126 GDSC2; CTRP2 6.6996 12.7414 3.2251 10.5836
SK-N-AS GDSC2; CTRP2 6.9022 14.9893 2.2652 13.9783
Kelly GDSC2; CTRP2 7.8723 14.099 3.4199 7.9133
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 3.3203 7.3491 0.584 8.3719
SNU-869 CTRP2 10.1369 21.4702 1.4176 11.9859
Cancer Drug Sensitivity Data Curated from 88 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-361 GDSC2; CTRP2 -0.0299 4.3423 -0.2096 44.7361
MDA-MB-330 GDSC2 -0.014 4.8961 -0.8435 33.8949
UACC-893 GDSC2 0.1962 3.2613 -0.0729 32.5673
SK-BR-3 CTRP2 0.7789 5.0913 0.5274 35.853
OCUB-M GDSC2 0.7883 2.7358 0.692 23.5569
MDA-MB-453 GDSC2; CTRP2 1.4501 6.4681 0.9087 32.3599
EFM-19 GDSC2 1.592 7.6037 -0.389 25.5713
EFM-192A GDSC2; CTRP2 1.675 4.3349 1.6112 29.3237
CAL-148 GDSC2 1.6772 5.7255 0.5747 20.6618
MDA-MB-175-VII GDSC2 1.8833 6.2442 0.5388 20.1217
HCC1954 GDSC2 1.9467 4.9831 1.1818 16.4943
BT-20 GDSC2; CTRP2 2.0624 5.8369 1.7536 27.5851
HCC1599 GDSC2 2.216 5.5422 1.1947 16.9685
T-47D GDSC2; CTRP2 2.3803 9.8933 0.5964 30.3091
HCC1569 GDSC2 2.5987 9.5884 -0.4327 22.457
Hs 578T GDSC2; CTRP2 2.7955 7.7416 1.9247 24.7438
AU565 GDSC2; CTRP2 2.8665 8.834 1.5551 25.8316
CAL-51 GDSC2; CTRP2 2.8753 6.2763 2.5198 22.3599
CAL-85-1 GDSC2; CTRP2 3.0013 9.9407 1.2103 26.6035
MCF-7 GDSC2 3.0425 6.2496 1.6192 10.553
HCC1419 GDSC2; CTRP2 3.1065 6.9371 2.5566 21.5369
UACC-812 GDSC2 3.1468 8.0173 0.1291 11.4921
ZR-75-30 GDSC2; CTRP2 3.2484 8.8869 1.9282 23.4385
HCC2157 GDSC2 3.3617 5.978 1.2708 4.1684
BT-474 GDSC2; CTRP2 3.3881 9.5647 1.7712 23.6168
HDQ-P1 GDSC2 3.5128 8.4073 0.9365 13.0942
MFM-223 GDSC2 3.6187 7.719 1.3655 10.4567
HCC1937 GDSC2 3.7139 5.846 2.3698 4.5257
JIMT-1 GDSC2 3.9156 7.1042 1.8999 6.7368
CAL-120 GDSC2 3.922 6.3174 2.29 4.5273
HCC70 GDSC2 3.9598 8.2845 1.3501 9.7191
Evsa-T GDSC2 4.0944 6.0859 2.5185 2.9359
HCC1395 GDSC2 4.0968 7.4576 1.8589 6.5721
HCC1143 GDSC2; CTRP2 4.3239 9.6847 2.6474 17.9177
COLO 824 GDSC2 4.3731 13.1385 -0.7402 18.9929
HCC2218 GDSC2 4.4057 8.9208 1.3662 9.438
HCC1806 GDSC2 4.4374 8.374 1.6542 6.9994
CAMA-1 GDSC2 4.4551 9.0307 1.348 8.6343
ZR-75-1 CTRP2 4.5379 8.6439 3.3452 14.6238
YMB-1-E GDSC2 4.6107 8.7611 1.587 7.706
MDA-MB-415 GDSC2; CTRP2 4.6945 7.5194 4.0124 11.5629
BT-483 GDSC2 4.8418 10.4338 0.9392 10.0064
MDA-MB-157 GDSC2 5.1394 9.6978 1.4915 6.5468
MDA-MB-436 GDSC2 5.1592 7.9563 2.2975 2.4609
MRK-nu-1 GDSC2 5.1752 6.544 2.8744 0.2828
HCC1187 GDSC2 5.245 8.4873 2.1112 3.232
MDA-MB-468 GDSC2; CTRP2 5.5739 11.1704 3.0795 13.3452
HCC1500 GDSC2; CTRP2 5.6281 8.0421 4.6804 6.591
HCC38 GDSC2; CTRP2 5.7686 9.7552 3.9544 9.3287
DU4475 GDSC2; CTRP2 5.7686 7.9438 4.8561 5.5541
Hs 578Bst CTRP2 5.9036 11.7634 3.0667 12.7234
HCC1428 GDSC2; CTRP2 6.1637 7.8408 5.2435 3.1431
BT-549 GDSC2; CTRP2 6.2264 13.2655 2.5844 14.0108
MDA-MB-231 GDSC2; CTRP2 7.4123 12.4311 3.9068 6.6516
BT 239 CTRP2 1.9763 9.6126 0.2988 32.3847
BT 248 CTRP2 2.4496 8.192 1.3804 27.6529
BT 482 CTRP2 3.3317 9.5536 1.7191 23.9551
BT 271 CTRP2 3.6136 10.0641 1.77 23.0167
BT 231 CTRP2 3.6821 11.0867 1.3594 24.2622
BT 416 CTRP2 3.709 6.0263 3.5007 16.2868
BT 245 CTRP2 3.7822 7.9234 2.8938 18.3615
BT 286 CTRP2 4.314 10.883 2.0659 20.1595
BT 359 CTRP2 4.542 13.469 1.0161 23.2694
BT 139 CTRP2 4.6416 10.3166 2.6503 17.1384
BT 228 CTRP2 4.7114 12.5156 1.6403 20.7584
BT 145 CTRP2 4.8031 8.9894 3.4424 13.5856
BT147 CTRP2 5.0358 12.7011 1.8422 19.2953
BT 131 CTRP2 5.0565 11.358 2.5253 16.6729
BT164 CTRP2 5.0845 11.3243 2.5672 16.4467
BT 340 CTRP2 5.2261 8.8441 3.9153 10.6631
BT 330 CTRP2 5.2731 11.6297 2.5856 15.9593
BT 112 CTRP2 5.3116 10.2304 3.3131 12.9525
BT 172 CTRP2 5.8723 11.7106 3.0667 12.7861
BT 216 CTRP2 5.8767 10.6588 3.596 10.6038
BT 187 CTRP2 5.8837 13.6796 2.0921 16.5689
BT 422 CTRP2 5.9148 10.2573 3.829 9.5583
BT 179 CTRP2 6.1743 11.1309 3.6086 9.9723
BT 320 CTRP2 6.2065 12.4261 2.9876 12.4508
BT 328 CTRP2 6.3844 11.0326 3.8277 8.6719
BT 428 CTRP2 6.3908 10.6512 4.0229 7.847
BT 504 CTRP2 6.6103 11.8176 3.6147 9.1494
BT 159 CTRP2 6.8904 13.1771 3.1562 10.5277
BT 232 CTRP2 6.9847 13.4331 3.1014 10.5851
BT 440 CTRP2 7.1954 16.0992 1.9411 14.6542
BT 444 CTRP2 7.3613 8.5704 5.6384 0.3204
BT 498 CTRP2 7.7579 8.9331 5.6629 0.1419
BT 333 CTRP2 7.8582 17.7695 1.6163 14.6789
BT 224 CTRP2 10.0059 18.6635 2.6512 7.9733
⏷ Show the Full List of 88 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC2; CTRP2 -1.2898 16.3262 -6.0076 49.5028
42-MG-BA GDSC2; CTRP2 0.0406 88.732 -40.4033 49.0729
D-247MG GDSC2 1.666 5.3017 0.7541 21.7064
D283 Med GDSC2; CTRP2 2.6135 7.2307 1.9203 25.2995
D-336MG GDSC2 2.6477 8.0353 0.3822 20.1199
PFSK-1 GDSC2 2.7056 7.9365 -0.1724 14.4049
MOG-G-CCM GDSC2 2.8535 5.0803 1.3568 4.7276
SK-MG-1 GDSC2 3.0109 6.6435 0.705 8.3739
KINGS-1 GDSC2 3.0525 7.7093 0.2102 11.2544
U-87MG ATCC GDSC2 3.1125 6.2992 0.9475 6.6466
KS-1 [Human Krukenberg tumour] GDSC2 3.1761 6.5907 0.8507 7.0908
GB-1 GDSC2 3.3657 6.0847 1.2231 4.442
H4 GDSC2 3.4889 7.8194 0.4746 8.6385
LN-18 GDSC2 3.5412 4.813 1.8865 0.667
LN-405 GDSC2 3.6302 5.5104 1.6407 1.685
CAS-1 GDSC2 3.7309 5.7517 1.5901 1.8058
GI-1 GDSC2 3.8445 6.8533 1.1643 3.9047
Hs 683 GDSC2; CTRP2 3.8746 7.0777 3.3315 16.4309
Daoy GDSC2 4.0084 7.494 0.9696 4.7128
MOG-G-UVW GDSC2 4.077 6.1405 1.6012 1.3523
YH-13 GDSC2; CTRP2 4.0939 9.7949 2.3704 19.5596
M059J GDSC2 4.1546 6.9299 1.3065 2.6677
SF295 GDSC2 4.1561 9.6404 0.8281 13.1957
SW1783 GDSC2; CTRP2 4.1764 7.0658 3.658 14.3402
LN-229 GDSC2 4.2437 6.8307 1.396 2.1094
NMC-G1 GDSC2 4.275 6.7044 2.3437 3.9083
ONS-76 GDSC2 4.3417 6.0696 1.7473 0.5828
Onda 10 GDSC2 4.3852 7.0263 2.2632 4.168
SF126 GDSC2 4.4836 9.4231 1.1769 10.3938
SW1088 GDSC2; CTRP2 4.4885 9.4005 2.9421 16.3541
D-263MG GDSC2 4.5538 5.7932 1.9256 0.1072
D-392MG GDSC2 4.5588 8.3909 0.8865 4.2681
Onda 11 GDSC2 4.5596 7.7071 2.0551 5.05
D-502MG GDSC2 4.5817 13.6263 -0.8218 20.1759
D-245MG GDSC2 4.5916 16.4937 -2.2381 25.2452
D-423MG GDSC2 4.6232 12.0348 -0.0033 16.3806
D-566MG GDSC2 4.7179 6.9786 2.4841 2.3655
D-542MG GDSC2 4.8778 14.5974 -1.0775 20.479
SNB-75 GDSC2; CTRP2 4.891 12.3692 1.8759 19.4995
GaMG GDSC2; CTRP2 5.1188 9.9959 3.2526 13.6267
Becker GDSC2; CTRP2 5.1469 8.1336 4.1822 9.751
YKG-1 GDSC2; CTRP2 5.1475 9.4312 3.5557 12.3217
KNS-81-FD GDSC2 5.3195 14.7056 -0.8032 18.3226
U-118MG GDSC2; CTRP2 5.5016 7.8975 4.6341 7.0661
DK-MG GDSC2; CTRP2 5.5771 9.3475 3.9889 9.584
SF268 GDSC2; CTRP2 5.5941 11.0614 3.1514 13.0105
GMS-10 CTRP2 5.6245 12.3257 2.5473 15.3613
SF539 GDSC2; CTRP2 5.6949 12.2466 2.6474 14.8229
A-172 GDSC2; CTRP2 5.7238 12.3215 2.6349 14.8128
DBTRG-05MG GDSC2; CTRP2 5.9916 10.1975 3.9237 9.0113
KNS-60 CTRP2 6.0315 8.7647 4.6735 5.7871
KALS-1 GDSC2; CTRP2 6.0323 10.9833 3.5648 10.4265
T98G GDSC2; CTRP2 6.0413 12.0337 3.0471 12.5307
KNS-81 CTRP2 6.2751 8.5677 4.9695 4.0923
GOS-3 CTRP2 6.5067 12.2305 3.3277 10.5122
M059K CTRP2 6.7761 14.1648 2.5767 13.0169
CCF-STTG1 CTRP2 7.0482 13.261 3.2347 9.9433
U-251MG GDSC2; CTRP2 7.1127 11.6813 4.0591 6.4892
KNS-42 GDSC2; CTRP2 7.4727 13.0627 3.6426 7.6233
8-MG-BA GDSC2; CTRP2 7.5184 13.3706 3.5252 8.0238
TM-31 CTRP2 9.679 18.5124 2.5165 8.8479
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 2.1032 6.898 -0.1508 16.0533
ETK-1 GDSC2 3.123 6.9528 0.6354 8.5264
TGBC1TKB GDSC2 3.3025 5.4081 1.4993 2.9527
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC2 1.8258 7.229 -0.5565 19.2008
AN3-CA GDSC2; CTRP2 2.7152 9.4897 1.1169 27.7266
KLE GDSC2 3.3275 6.1867 1.1497 4.9543
JHUEM-1 CTRP2 3.4486 7.8485 2.5748 20.4921
HEC-1-A CTRP2 3.6647 9.7904 1.9469 22.2446
ESS-1 GDSC2; CTRP2 3.8948 10.3161 1.9304 21.7064
RL95-2 GDSC2 4.3913 5.9081 1.8264 0.3373
EFE-184 CTRP2 4.7206 12.1556 1.8258 20.0728
HEC-151 CTRP2 4.8211 8.1691 3.8462 11.9066
MFE-296 GDSC2; CTRP2 5.4948 9.3962 3.891 10.1676
EN GDSC2; CTRP2 6.1566 12.5397 2.8898 12.9391
MFE-319 GDSC2; CTRP2 6.3587 8.5113 5.0621 3.5605
HEC-50B CTRP2 6.5394 9.3082 4.8044 4.3311
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-909 GDSC2 1.997 4.5562 0.9236 9.8427
A-498 GDSC2 3.0732 5.2827 1.4111 3.9133
KTCTL-13 GDSC2 3.1576 6.0238 1.8318 9.9165
KTCTL-195 GDSC2 3.4873 6.8861 0.9227 5.977
SW13 GDSC2 3.6276 8.5536 0.2157 9.837
KTCTL-140 GDSC2 3.7362 9.3508 0.6454 15.3421
NCC021 GDSC2 3.7564 6.7875 1.9366 7.5791
OS-RC-2 GDSC2 3.7594 5.9106 1.5366 2.0363
KMRC-3 CTRP2 3.7836 9.6373 2.136 21.2376
A-704 GDSC2 3.8192 10.0919 -0.397 12.8067
KMRC-20 GDSC2 3.9344 5.7636 1.6869 1.1251
LB1047-RCC GDSC2 3.9461 11.2303 -0.1249 18.7385
KTCTL-26A GDSC2 3.9601 7.5272 1.7245 8.3797
CAL-54 GDSC2; CTRP2 4.0647 9.8334 2.3236 19.8115
LB996-RCC GDSC2 4.0673 7.9845 0.7793 5.681
TK-10 GDSC2 4.1758 7.5269 1.0539 3.9684
KTCTL-1M GDSC2 4.2841 9.0019 1.2385 10.5114
LB2241-RCC GDSC2 4.3197 9.0919 1.2203 10.5317
SN12C GDSC2 4.4864 6.2951 1.7222 0.5753
769-P GDSC2 4.5718 10.638 -0.1437 9.8236
BB65-RCC GDSC2 4.6053 7.3434 2.2535 3.8166
SW156 GDSC2 4.6726 10.0178 1.022 10.8409
RXF 393L GDSC2 4.9677 10.415 1.0356 9.2511
HA7-RCC GDSC2 5.0226 12.1178 0.2481 13.0902
UO-31 GDSC2; CTRP2 5.0485 10.7042 2.8402 15.4485
TUHR10TKB CTRP2 5.305 8.3127 4.2475 9.1122
KMRC-2 CTRP2 5.4403 9.9026 3.5913 11.5287
KMRC-1 GDSC2; CTRP2 5.4503 8.645 4.221 8.8933
NCC010 GDSC2 5.6004 15.3459 -0.9132 16.9753
VMRC-RCW GDSC2; CTRP2 5.9411 10.2561 3.8519 9.4106
VMRC-RCZ GDSC2; CTRP2 6.1382 10.089 4.0997 7.9924
KTCTL-21 GDSC2 6.1992 18.96 -2.2481 21.6709
ACHN GDSC2; CTRP2 6.2304 9.7826 4.3279 6.8631
786-O GDSC2; CTRP2 6.3073 7.9474 5.3021 2.6478
TUHR14TKB CTRP2 6.4065 18.685 0.0233 33.8683
Caki-1 GDSC2; CTRP2 6.9751 14.4567 2.5865 12.6255
Caki-2 CTRP2 8.3317 18.3114 1.6969 13.6403
RCC10RGB GDSC2; CTRP2 9.3892 16.272 3.3762 6.107
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP2d CTRP2 -1.7224 6.8576 -2.667 51.2981
SNU-1033 CTRP2 0.3679 124.7566 -58.106 49.1937
T84 GDSC2; CTRP2 1.6282 6.4922 1.0955 31.1797
GP5d GDSC2 1.8448 4.3207 0.9015 10.4813
SNU-C1 GDSC2; CTRP2 2.0004 4.9697 1.8712 27.3795
DiFi GDSC2 2.223 7.4322 -0.3161 16.6242
COLO 320 CTRP2 2.2444 8.3229 1.1109 29.1583
NCI-H747 GDSC2; CTRP2 2.2702 6.7612 1.7097 27.0832
SW48 GDSC2 2.5003 9.1322 -0.9357 19.0791
SK-CO-1 GDSC2 2.76 5.7134 0.976 7.3242
SW948 GDSC2; CTRP2 2.8472 7.2835 2.1527 23.7731
HCT 116 GDSC2 2.8899 8.9325 -0.5228 15.834
LS411N GDSC2 3.0465 5.0386 1.5097 3.3782
CaR-1 GDSC2 3.1648 6.7798 0.7504 7.7275
LS180 GDSC2 3.1901 6.2696 1.0164 6.0509
SNU-175 GDSC2 3.2422 5.6394 1.3531 3.9173
SNU-C5 GDSC2; CTRP2 3.2609 9.0238 1.8816 23.5716
LS513 GDSC2 3.2662 7.6514 0.3973 9.6152
HT-29 GDSC2 3.3797 9.2231 0.4193 16.1682
NCI-H716 GDSC2; CTRP2 3.4284 9.2861 1.937 22.9127
COLO 320HSR GDSC2 3.4353 9.3325 -0.3043 13.2269
HT-55 GDSC2; CTRP2 3.5883 8.583 2.4105 20.7284
CCK-81 GDSC2; CTRP2 3.6124 9.1322 2.1927 21.4791
SNU-407 GDSC2; CTRP2 3.6274 9.0219 2.2573 21.1983
COLO205 GDSC2 3.7571 9.8014 -0.2997 12.4282
SW626 GDSC2 3.8805 9.2689 0.046 10.2368
SW1463 GDSC2 3.9117 6.1928 1.4957 2.0395
SNU-283 GDSC2 4.0252 8.4397 1.3229 10.6539
HCC2998 GDSC2 4.0265 6.2274 1.5402 1.6838
LoVo GDSC2; CTRP2 4.1456 8.884 2.8434 17.6001
SNU-C2B GDSC2 4.2868 7.5875 1.0902 3.6024
C2BBe1 GDSC2; CTRP2 4.3124 10.7458 2.1303 19.9233
COLO 678 GDSC2; CTRP2 4.399 9.9928 2.574 18.0193
HT115 GDSC2 4.4012 8.6724 1.4841 8.0051
SNU-1040 GDSC2 4.4237 6.038 1.792 0.4102
SNU-503 CTRP2 4.6181 12.6785 1.4747 21.5554
SW837 GDSC2 4.6553 6.5089 1.711 0.5166
LS1034 GDSC2; CTRP2 4.8664 7.404 4.2393 10.2169
HCT 15 GDSC2; CTRP2 4.9366 8.7522 3.6843 12.2842
SNU-C4 CTRP2 4.9568 9.7848 3.2052 14.1877
CL-11 GDSC2; CTRP2 5.0112 10.1557 3.0749 14.5906
SW1417 GDSC2; CTRP2 5.0994 9.8153 3.3232 13.3826
SNU-81 GDSC2 5.2955 7.1445 2.6993 0.7023
LS123 GDSC2; CTRP2 5.3043 10.4587 3.1937 13.4562
RCM-1 [Human ESC] GDSC2; CTRP2 5.4014 11.0075 3.0085 13.9979
NCI-H508 GDSC2; CTRP2 5.5181 15.674 0.7843 21.8344
SW1116 GDSC2; CTRP2 5.5203 10.3045 3.4633 11.8865
HCT 8 CTRP2 5.7265 12.2058 2.695 14.5704
SNU-61 GDSC2; CTRP2 5.7634 13.5966 2.0316 17.0391
SW620 GDSC2; CTRP2 5.8064 10.5434 3.5936 10.7549
CW-2 GDSC2; CTRP2 6.1081 13.6049 2.3171 15.272
KM12 GDSC2; CTRP2 6.2961 7.6989 5.4164 2.192
HCC-56 CTRP2 6.5254 7.8377 5.51 1.4698
MDST8 GDSC2; CTRP2 6.7418 14.3178 2.4735 13.4764
RKO GDSC2; CTRP2 6.8829 9.8381 4.7927 3.8462
COLO201 CTRP2 13.1961 27.5417 0.5094 11.1127
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.8593 6.4923 1.7947 0.2414
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 2.8192 6.2066 1.4418 12.2082
Hep-G2/C3A GDSC2 3.9707 5.6745 1.7395 0.8769
Huh-7 GDSC2 4.1539 5.898 1.7332 0.7554
JHH-7 GDSC2 4.5313 11.6822 -0.6696 12.6327
HLE GDSC2 4.6444 7.025 1.5092 1.2052
HuH-6 CTRP2 5.0471 9.9044 3.2312 13.8758
SNU-423 GDSC2; CTRP2 5.0821 10.3446 3.0477 14.54
SNU-475 CTRP2 5.219 10.621 3.0364 14.2814
HuH-1 GDSC2; CTRP2 5.2351 10.5109 3.1054 13.9667
JHH-1 GDSC2; CTRP2 5.5275 9.5801 3.8293 10.3543
SNU-398 GDSC2; CTRP2 5.5675 10.796 3.2603 12.6216
SNU-761 CTRP2 5.8035 9.3715 4.176 8.33
SK-HEP-1 GDSC2; CTRP2 5.9062 8.0154 4.9415 4.9095
Hep-G2 CTRP2 5.9711 11.1967 3.4069 11.199
JHH-4 GDSC2; CTRP2 5.9854 8.7969 4.6186 6.1077
JHH-2 GDSC2; CTRP2 6.0046 11.2373 3.4147 11.1012
PLC/PRF/5 CTRP2 6.0531 9.3998 4.3739 7.0044
SNU-449 GDSC2; CTRP2 6.3359 11.5562 3.5275 10.0048
SNU-387 GDSC2; CTRP2 6.599 14.7643 2.1376 15.0093
JHH-6 GDSC2; CTRP2 7.0305 7.862 5.7684 0.1796
HLF CTRP2 7.2239 13.0482 3.4702 8.7062
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 207 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1341 GDSC2; CTRP2 -0.0374 4.4441 -0.2344 41.0202
EPLC-272H GDSC2; CTRP2 0.1609 7.5051 -0.8273 41.3246
DV-90 CTRP2 0.2076 11.6723 -2.4162 43.1851
NCI-H1648 GDSC2 0.2277 4.6806 -0.8615 26.7922
NCI-H2171 GDSC2 0.433 3.317 0.1705 30.314
NCI-H69 GDSC2 1.1685 4.4862 0.1744 17.325
NCI-H1623 GDSC2; CTRP2 1.2621 7.0522 0.519 34.151
RERF-LC-Sq1 GDSC2 1.6686 6.8545 -0.5095 19.4676
NCI-H292 GDSC2 1.7946 7.0148 0.0873 24.7263
NCI-H1563 GDSC2; CTRP2 2.0671 6.317 1.6265 28.0054
NCI-H1105 GDSC2; CTRP2 2.2893 10.499 0.2368 31.5865
NCI-H1734 GDSC2 2.3825 6.0233 1.1261 16.8273
NCI-H2066 GDSC2 2.5454 5.745 0.7929 9.0371
COR-L311 GDSC2 2.5848 5.0543 1.1681 6.5747
NCI-H720 GDSC2 2.6884 4.9551 1.2969 5.4988
SBC-1 GDSC2 2.6936 8.3757 0.2541 20.639
EMC-BAC-2 GDSC2 2.7665 7.1243 0.2805 11.5851
NCI-H1975 GDSC2 2.7806 6.3149 0.6936 9.0263
NCI-H2795 GDSC2 2.7853 11.173 -1.7237 21.8827
COR-L32 GDSC2 2.8259 6.1455 1.4781 11.9835
LUDLU-1 CTRP2 2.8502 8.3771 1.7289 25.2761
Calu-3 GDSC2 2.8506 5.4857 1.1561 5.9771
HCC4006 CTRP2 2.8565 8.0075 1.8851 24.7066
CPC-N GDSC2 2.8598 9.5161 -0.8373 17.5586
NCI-H2009 GDSC2 2.8902 7.2745 0.3018 11.1287
NCI-H835 GDSC2 2.8961 14.5616 -3.3263 27.269
NCI-H1048 GDSC2 2.9001 5.9457 0.9664 7.034
NCI-H64 GDSC2 2.9145 4.9381 1.4687 3.9029
HARA [Human squamous cell lung carcinoma] GDSC2 2.9482 8.4277 -0.2261 14.0458
NCI-H2170 GDSC2 2.9625 6.5577 0.7113 8.455
NCI-H3122 GDSC2 2.9728 7.2624 0.371 10.4996
Lu-99A GDSC2 2.9894 6.4513 0.7837 7.9435
NCI-H1703 GDSC2; CTRP2 3.0335 9.4445 1.4636 25.6677
Lu-134-A GDSC2 3.0421 8.3775 0.5573 17.8874
HCC44 GDSC2 3.0631 6.2464 0.9378 6.8203
NCI-H82 GDSC2 3.065 6.8266 0.6548 8.5485
NCI-H1184 CTRP2 3.1068 7.3011 2.4251 22.0204
NCI-H1993 GDSC2 3.1186 5.6633 1.2595 4.7319
NCI-H596 GDSC2 3.126 7.8073 0.2171 11.0276
NCI-H2110 GDSC2; CTRP2 3.1302 7.797 2.2589 22.5653
Ms-1 GDSC2 3.1342 5.994 1.1108 5.6003
Lu-65 GDSC2; CTRP2 3.1598 11.7741 0.5249 28.2834
NCI-H2731 GDSC2 3.1772 6.7888 0.755 7.671
COR-L23 GDSC2 3.2177 7.7182 0.3291 10.1378
RERF-LC-KJ GDSC2 3.2409 6.4892 0.9455 6.3682
NCI-H1781 GDSC2 3.2498 4.8541 1.72 1.8121
COR-L279 GDSC2 3.291 6.7875 0.8361 6.9192
NCI-H1876 GDSC2 3.3245 6.9474 0.7821 7.1705
NCI-H847 GDSC2 3.3478 9.2672 -0.3373 13.6256
LB647-SCLC GDSC2 3.3727 5.233 2.4084 5.638
NCI-H1688 GDSC2 3.384 6.9758 0.8096 6.8733
NCI-H3255 GDSC2 3.3963 5.19 2.4491 4.829
IST-SL2 GDSC2 3.4202 8.835 0.6469 14.8837
NCI-H524 GDSC2 3.4353 6.8303 0.9145 6.1344
LCLC-97TM1 GDSC2; CTRP2 3.4401 8.9553 2.0954 22.3035
PaCa-3 GDSC2 3.4431 7.1484 0.7671 6.9993
LC-2/ad GDSC2 3.4431 6.7022 1.7316 9.7056
NCI-H1755 GDSC2; CTRP2 3.4797 8.1657 2.4762 20.7772
BEN GDSC2 3.5227 8.1927 1.0518 13.6224
LC-1/sq GDSC2 3.5296 7.608 0.6051 7.7748
NCI-H2369 GDSC2 3.5345 5.553 1.57 2.1826
COR-L303 GDSC2 3.5371 8.0212 1.1491 13.0054
Lu-135 GDSC2 3.5431 5.6501 1.5316 2.3745
SK-MES-1 GDSC2 3.5936 5.9048 1.4465 2.7573
HCC366 GDSC2 3.6007 9.3046 0.5596 14.8638
HCC827 GDSC2 3.6225 7.4317 0.7527 6.7032
NCI-H2373 GDSC2 3.6237 8.1145 0.4257 8.6249
NCI-H211 GDSC2 3.6549 6.1617 1.3663 3.0983
NCI-H1838 GDSC2 3.6623 6.5632 1.187 4.0941
NCI-H727 GDSC2 3.666 6.3544 1.2852 3.5313
NCI-H1436 GDSC2 3.6674 5.8411 2.3374 5.298
NCI-H2818 GDSC2 3.6942 6.6292 1.1761 4.0989
LOU-NH91 GDSC2; CTRP2 3.6958 8.4589 2.5752 19.8145
IST-SL1 GDSC2 3.702 6.508 2.0335 7.1134
NCI-H526 GDSC2 3.706 5.4844 1.6908 1.3503
SBC-5 GDSC2 3.7209 4.6841 2.0092 0.1772
SHP-77 GDSC2 3.73 5.5963 1.6559 1.4869
NCI-H2122 GDSC2; CTRP2 3.7332 7.3328 3.0822 17.7753
NCI-H2141 GDSC2 3.7665 7.8559 0.6465 7.0295
NCI-H2461 GDSC2 3.7925 10.698 -0.7127 14.5193
NCI-H345 GDSC2 3.8087 5.9429 2.3917 4.1955
A-549 GDSC2; CTRP2 3.834 8.8704 2.5349 19.6011
NCI-H358 GDSC2 3.871 10.9373 -0.7729 14.6371
NCI-H1693 GDSC2; CTRP2 3.8801 10.0807 2.0262 21.3936
NCI-H196 GDSC2 3.9094 5.5193 1.7733 0.7975
DMS 79 GDSC2 3.921 6.9734 1.9682 6.3393
EMC-BAC-1 GDSC2 3.9281 11.829 -0.4377 20.2398
NCI-H250 GDSC2 3.9309 9.9411 0.5051 14.3089
NCI-H146 GDSC2 3.9453 6.8428 2.0502 6.4064
RERF-LC-MS GDSC2; CTRP2 3.9458 7.4049 3.2791 16.4326
NCI-H1568 GDSC2 3.98 7.6864 0.8634 5.3637
NCI-H2030 GDSC2 3.9846 10.1621 0.4372 15.7898
NCI-H1944 GDSC2; CTRP2 4.0062 9.8684 2.2497 20.2391
NCI-H1836 GDSC2 4.0183 7.9965 1.5366 9.3836
COLO 668 GDSC2; CTRP2 4.021 9.4965 2.4373 19.4895
NCI-H1694 GDSC2; CTRP2 4.0306 7.2592 3.4271 15.6301
LCLC-103H GDSC2 4.0321 9.1421 0.2102 8.9856
NCI-H740 GDSC2 4.0369 6.6422 2.2133 5.1916
HCC15 GDSC2 4.1015 6.2239 1.5787 1.4256
NCI-H1437 GDSC2 4.1138 14.1785 -1.4614 23.8663
NCI-H2291 GDSC2 4.1485 12.1449 -0.4211 19.5666
EBC-1 GDSC2; CTRP2 4.1633 7.0994 3.6309 14.4805
NCI-H1573 GDSC2 4.1674 5.7978 1.7773 0.5949
RERF-LC-Ad2 CTRP2 4.1817 11.5989 1.5948 22.1855
NCI-H650 GDSC2 4.2295 6.3748 1.5783 1.2987
COR-L321 GDSC2 4.3039 6.4205 2.4945 2.9781
DMS 114 GDSC2; CTRP2 4.3078 11.218 1.8984 20.7909
UMC-11 GDSC2 4.3125 6.2042 1.6835 0.816
Lu-165 GDSC2 4.3156 5.6408 1.8929 0.218
NCI-H2228 GDSC2; CTRP2 4.3378 9.3515 2.8178 17.2164
LK-2 GDSC2 4.3779 7.2097 1.3041 2.3876
NCI-H2722 GDSC2 4.3788 6.1748 1.723 0.637
NCI-H520 GDSC2; CTRP2 4.3858 9.6263 2.7353 17.422
NCI-H2591 GDSC2 4.3911 6.9954 1.4012 1.9127
SBC-3 GDSC2 4.4222 6.5436 1.5994 1.0423
NCI-H1395 CTRP2 4.4481 8.7096 3.2256 15.3254
NCI-H1666 GDSC2; CTRP2 4.4572 14.4176 0.4712 25.1567
HOP-92 GDSC2; CTRP2 4.4613 9.209 3.0058 17.7034
NCI-H322M GDSC2 4.5013 9.5769 0.31 7.501
NCI-H2227 GDSC2 4.5122 10.1746 0.8299 11.2748
NCI-H1770 GDSC2 4.5125 7.0555 2.3293 3.5492
LXF 289 GDSC2; CTRP2 4.5181 8.6273 3.3332 14.7211
CAL-12T GDSC2 4.5448 15.0421 -1.5528 23.0858
NCI-H1793 GDSC2; CTRP2 4.5477 8.9967 3.1903 15.2198
NCI-H446 GDSC2; CTRP2 4.5485 9.8187 2.8012 16.7667
NCI-H2135 GDSC2 4.5697 6.6492 2.5471 2.0466
HCC2935 CTRP2 4.5725 9.9233 2.774 16.8164
NCI-H513 GDSC2 4.5805 6.7426 1.5915 0.9477
NCI-H1581 GDSC2 4.6238 6.3054 1.7728 0.3703
DMS 454 CTRP2 4.6528 13.1726 1.2632 22.1956
NCI-H2085 GDSC2; CTRP2 4.6777 9.6895 2.9869 15.7196
Lu-139 GDSC2 4.6835 6.6758 1.6605 0.6491
HCC33 GDSC2 4.6992 10.9865 0.568 13.277
NCI-H2081 GDSC2; CTRP2 4.727 18.6809 -1.4027 29.3071
HCC78 GDSC2 4.7329 13.6822 -1.496 16.086
NCI-H1963 GDSC2 4.7404 6.686 1.6798 0.5607
COR-L105 GDSC2; CTRP2 4.7473 11.2552 2.2923 18.2761
NCI-H2196 GDSC2; CTRP2 4.7562 9.6056 3.1022 15.0714
NCI-H2342 GDSC2; CTRP2 4.7771 10.2026 2.8335 16.097
NCI-H2347 GDSC2 4.7983 6.9283 1.613 0.7282
NCI-H1092 GDSC2; CTRP2 4.81 8.9252 3.4796 13.4185
ChaGo-K-1 GDSC2; CTRP2 4.8192 12.3745 1.8081 19.9094
DMS 273 GDSC2; CTRP2 4.8548 10.5022 2.7603 16.207
NCI-H2869 GDSC2 4.8918 9.0233 1.6494 6.1585
NCI-H748 GDSC2 4.899 7.406 2.3962 2.5638
COR-L88 GDSC2 4.9488 7.1542 1.5902 0.7097
NCI-H290 GDSC2 5.0269 9.8547 1.3438 8.2397
NCI-H2023 GDSC2; CTRP2 5.0723 10.7158 2.8563 15.331
NCI-H647 GDSC2; CTRP2 5.0989 11.3504 2.5674 16.4138
NCI-H1435 GDSC2; CTRP2 5.1033 9.1196 3.6661 11.9692
NCI-H1155 GDSC2 5.1043 6.6406 1.8307 0.13
NCI-H2595 GDSC2 5.1216 7.3553 1.5854 0.6297
NCI-H2803 GDSC2 5.1588 6.9311 2.7225 0.7182
NCI-H1299 GDSC2 5.1616 12.7584 -0.7619 11.8034
EKVX GDSC2; CTRP2 5.1905 10.7303 2.9566 14.6662
NCI-H209 GDSC2 5.1972 6.9407 1.7614 0.2098
NCI-H2810 GDSC2 5.1986 11.3188 0.7588 10.214
NCI-H1355 GDSC2; CTRP2 5.2346 9.1896 3.7547 11.3059
COR-L51 CTRP2 5.2521 8.7739 3.9738 10.3625
NCI-H841 GDSC2; CTRP2 5.3821 8.7933 4.0853 9.608
Sq-1 CTRP2 5.3923 11.7461 2.6334 15.5141
NCI-H2286 CTRP2 5.4464 11.352 2.8772 14.4302
NCI-H1339 CTRP2 5.5051 9.0755 4.0589 9.4473
COR-L95 CTRP2 5.5388 11.3816 2.9436 13.968
NCI-H2126 CTRP2 5.6379 10.6624 3.3885 11.9484
Calu-6 GDSC2; CTRP2 5.6636 7.8441 4.8104 5.972
NCI-H838 GDSC2; CTRP2 5.6924 10.3046 3.6143 10.9021
NCI-H1650 GDSC2; CTRP2 5.7048 10.4971 3.5291 11.2295
NCI-H510A GDSC2 5.7076 7.3525 2.7877 0.304
LC-1/sq-SF CTRP2 5.75 10.4984 3.5676 10.9776
NCI-H810 GDSC2; CTRP2 5.7551 10.3595 3.6413 10.6614
NCI-H23 GDSC2; CTRP2 5.813 20.184 -1.2191 26.6538
A-427 GDSC2 5.8324 14.2727 -0.2288 13.639
NCI-H2405 GDSC2 5.8742 7.8473 1.6909 0.1709
NCI-H1915 GDSC2; CTRP2 5.9078 8.7763 4.563 6.4953
HOP-62 GDSC2; CTRP2 5.9177 11.0967 3.4119 11.284
DMS 53 GDSC2; CTRP2 5.9258 9.837 4.0484 8.6187
NCI-H522 GDSC2; CTRP2 5.9939 15.7148 1.167 19.6135
LK2 CTRP2 6.0216 6.709 5.6929 1.5221
PC-14 GDSC2; CTRP2 6.0355 8.1399 4.9892 4.4523
NCI-H2444 GDSC2; CTRP2 6.0973 7.7396 5.2405 3.2784
NCI-H1869 GDSC2; CTRP2 6.1858 11.4511 3.4579 10.5735
VMRC-LCD GDSC2; CTRP2 6.2773 9.1637 4.6744 5.3244
SK-LU-1 GDSC2; CTRP2 6.3155 11.6524 3.463 10.3087
NCI-H2804 GDSC2 6.3521 19.865 -2.5804 21.2598
NCI-H661 GDSC2; CTRP2 6.4622 9.6102 4.5966 5.3252
IA-LM GDSC2; CTRP2 6.467 9.4382 4.6855 4.9463
SW1271 GDSC2; CTRP2 6.4918 9.4532 4.6969 4.8568
NCI-H322 CTRP2 6.5039 9.6335 4.617 5.1693
NCI-H2029 GDSC2; CTRP2 6.583 12.8887 3.0601 11.4577
HCC1195 CTRP2 6.6168 14.7544 2.1568 14.9047
ABC-1 GDSC2 6.7213 15.6064 -0.2709 12.1855
HCC1438 CTRP2 6.7921 16.3455 1.503 16.9318
NCI-H1651 GDSC2; CTRP2 6.8135 14.1201 2.6282 12.7504
T3M-10 CTRP2 6.8582 15.498 1.9775 15.1232
NCI-H2087 GDSC2; CTRP2 6.8912 12.2739 3.6041 8.7092
NCI-H889 CTRP2 7.2087 10.6561 4.6218 4.0701
NCI-H226 GDSC2; CTRP2 7.52 8.6765 5.6639 0.2063
Calu-1 CTRP2 7.5554 16.615 1.9594 13.9705
KNS-62 GDSC2; CTRP2 7.61 12.7107 3.9086 6.3555
NCI-H441 GDSC2; CTRP2 7.8404 17.6925 1.6409 14.6229
NCI-H2172 GDSC2; CTRP2 8.045 17.0554 2.1041 12.6495
NCI-H1373 CTRP2 8.4051 15.809 2.9618 8.9179
SW1573 GDSC2; CTRP2 8.4054 19.4823 1.1771 15.2741
NCI-H1792 GDSC2; CTRP2 9.3846 18.0063 2.5654 9.0509
NCI-H460 GDSC2; CTRP2 10.2217 19.7494 2.2815 8.9945
Hs 888.Lu CTRP2 5.1722 9.7394 3.4278 12.7911
⏷ Show the Full List of 207 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.1263 6.7014 1.3902 2.2847
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 1.9492 10.5012 -0.1124 33.5246
Rh41 GDSC2 0.8941 4.0235 0.1102 18.761
Rh30 GDSC2 2.5951 5.2197 1.094 7.0136
A-204 GDSC2; CTRP2 2.7532 11.184 0.3964 29.7864
G-401 GDSC2; CTRP2 2.8628 9.4498 1.2861 26.7486
SW684 GDSC2 3.0829 5.9207 1.1105 5.7165
Rh18 CTRP2 3.2777 8.4943 2.127 22.6345
SW872 GDSC2 3.3674 6.9991 0.7869 7.0462
MFH-ino GDSC2 3.5755 6.1411 1.3283 3.4444
TE 441.T GDSC2; CTRP2 3.583 11.2577 1.182 25.1126
Tm87-16 CTRP2 3.6589 8.8281 2.3755 20.6704
TTC-709 CTRP2 3.7361 13.0132 0.489 26.8692
VA-ES-BJ GDSC2 3.7565 9.5302 -0.1679 11.7084
BT-16 CTRP2 4.0684 9.558 2.4557 19.2987
Hs 633.T GDSC2 4.1886 5.9437 1.7306 0.7394
STS-0421 GDSC2 4.3642 10.645 0.4886 14.524
G-402 GDSC2; CTRP2 4.7297 13.1187 1.3596 21.6908
EW-8 GDSC2 4.8714 6.243 1.884 0.1046
KYM-1 GDSC2; CTRP2 5.0938 11.4005 2.5381 16.5399
RD GDSC2; CTRP2 5.2616 15.52 0.6394 22.8336
MES-SA GDSC2; CTRP2 5.4595 8.6352 4.2343 8.8178
SW982 GDSC2; CTRP2 5.4832 7.8329 4.6482 7.0499
GCT GDSC2; CTRP2 5.7917 11.7565 2.9751 13.319
HT-1080 GDSC2; CTRP2 5.8924 8.5498 4.6628 6.1074
SK-UT-1 GDSC2; CTRP2 6.0917 16.6177 0.7971 20.6168
BT-12 CTRP2 6.1769 7.2684 5.539 1.8821
SK-LMS-1 GDSC2; CTRP2 6.3534 12.901 2.8701 12.6426
Hs 729.T CTRP2 6.581 14.217 2.3962 14.0674
RKN GDSC2; CTRP2 7.7157 11.6253 4.4934 3.9102
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.7391 11.245 0.3543 29.9443
A2780 GDSC2; CTRP2 0.0175 7.1113 -0.8524 41.9528
JHOS-4 GDSC2 0.888 5.4006 -0.0919 29.4022
IGROV-1 GDSC2; CTRP2 1.2656 6.4764 0.705 33.6046
SNU-840 CTRP2 2.6121 12.2123 -0.2192 31.8123
DOV13 GDSC2 2.9664 5.1797 1.388 4.2811
Caov-4 GDSC2 3.1753 6.5046 0.8921 6.8408
OVISE GDSC2 3.3916 9.2088 -0.2758 13.1785
OVKATE GDSC2 3.4899 6.2776 1.2121 4.2661
OVCAR-3 GDSC2 3.8562 5.559 1.733 1.0061
Kuramochi GDSC2 4.022 7.1382 1.1397 3.7473
OAW42 GDSC2; CTRP2 4.0488 8.3541 2.9835 17.3029
OAW28 GDSC2; CTRP2 4.1875 11.3738 1.709 21.7679
OV7 CTRP2 4.3737 13.9311 0.6348 24.8637
SK-OV-3 GDSC2; CTRP2 4.7604 11.8271 2.0239 19.2547
OVTOKO GDSC2 4.7664 12.3174 -0.8146 12.8561
FU-OV-1 GDSC2; CTRP2 4.7917 12.0978 1.9194 19.5678
ES-2 GDSC2 4.835 6.3397 1.8386 0.173
COV434 CTRP2 4.9033 9.2424 3.4173 13.4502
OVCAR-5 GDSC2; CTRP2 4.9604 12.2845 1.9805 18.9583
Caov-3 GDSC2; CTRP2 5.125 9.5789 3.4627 12.7543
JHOM-1 CTRP2 5.2119 8.2824 4.1736 9.6328
MCAS CTRP2 5.394 7.924 4.5197 7.7854
OVK18 GDSC2; CTRP2 5.5671 11.0949 3.1111 13.2313
RMG-I GDSC2; CTRP2 5.5896 12.9688 2.1962 16.7836
JHOS-2 GDSC2; CTRP2 5.7882 14.5103 1.5961 18.563
COV644 CTRP2 6.0063 20.6358 -1.2831 26.423
OV-90 GDSC2; CTRP2 6.1194 9.2368 4.5102 6.3052
EFO-27 GDSC2; CTRP2 6.129 9.7462 4.2635 7.323
OC 314 GDSC2; CTRP2 6.2646 11.5247 3.4855 10.3108
OV56 GDSC2; CTRP2 6.431 7.4011 5.6549 1.0242
TOV-21G GDSC2; CTRP2 6.6345 8.3338 5.3462 1.9719
COV362 CTRP2 6.7386 16.9664 1.1506 18.2247
TOV-112D GDSC2; CTRP2 6.7742 10.1267 4.5749 4.9023
EFO-21 GDSC2; CTRP2 7.4474 13.2445 3.5361 8.0892
HEY A8 CTRP2 7.5073 12.0479 4.1569 5.51
TYK-nu GDSC2; CTRP2 7.5424 12.2608 4.0786 5.7732
OVCAR-8 GDSC2; CTRP2 8.8228 14.8301 3.6945 5.5996
OVCAR-4 GDSC2; CTRP2 9.0833 10.9393 5.4474 0.152
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 8.4924 19.6977 1.1348 15.2748
SYO-1 CTRP2 8.5486 23.6327 -0.76 20.6821
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC2 3.4968 7.2901 0.7356 7.0706
MSTO-211H GDSC2; CTRP2 4.1693 8.0265 3.251 15.9401
NCI-H2452 GDSC2; CTRP2 4.3225 7.5671 3.6073 14.1384
MPP 89 GDSC2; CTRP2 6.0749 10.358 3.9129 8.8948
IST-Mes1 GDSC2; CTRP2 6.5839 13.0631 2.9739 11.8018
JL-1 CTRP2 7.1319 10.2953 4.7426 3.6943
NCI-H2052 GDSC2; CTRP2 8.4613 15.2178 3.2817 7.6215
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2; CTRP2 2.262 6.0485 1.9155 26.3941
LNCaP clone FGC GDSC2 2.6221 4.6593 1.393 5.0645
22Rv1 GDSC2 3.5296 10.778 -0.9467 16.3371
PC-3 GDSC2 3.6928 7.045 0.9817 5.2206
NCI-H660 GDSC2; CTRP2 4.1255 6.7908 3.7077 14.2946
PaCa-3 CTRP2 5.5785 9.1556 4.0853 9.1791
DU145 GDSC2; CTRP2 6.0031 10.5386 3.7628 9.6605
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2; CTRP2 6.2317 10.5717 3.9349 8.5058
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 4.1999 16.7661 -2.6832 26.1091
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-216 CTRP2 -0.1614 7.6364 -1.2212 43.2368
NCC-StC-K140 CTRP2 0.0095 7.0494 -0.8412 41.9681
NCI-N87 GDSC2 0.1187 7.4494 -2.2489 32.935
HGC-27 GDSC2; CTRP2 0.2175 5.0593 -0.0753 39.6017
AGS GDSC2 1.0386 4.8494 -0.1235 19.552
ECC10 GDSC2; CTRP2 1.2065 5.8377 0.8196 33.4665
HSC-39 GDSC2 1.2078 5.0744 -0.0656 18.5857
IM95 GDSC2; CTRP2 1.4727 8.816 0.097 34.5492
Fu97 GDSC2; CTRP2 1.7942 7.0781 1.0876 30.6597
MKN1 GDSC2 2.1141 7.1301 -0.2575 16.629
23132/87 GDSC2 2.3667 5.9143 0.5629 10.9745
MKN45 GDSC2 2.6618 6.451 0.5333 10.3302
SK-GT-2 GDSC2 2.6907 5.25 1.1527 6.3956
RERF-GC-1B GDSC2 2.777 5.9803 0.8568 8.0232
SNU-601 CTRP2 2.7784 13.0192 -0.4346 31.8669
GCIY GDSC2 3.3042 7.1968 0.6467 8.032
HuG1-N CTRP2 3.3412 12.0143 0.5887 27.6061
TGBC11TKB GDSC2 3.4236 8.187 0.2491 10.1151
RF-48 GDSC2 3.424 5.7028 1.4378 3.0885
NUGC-4 GDSC2 3.45 6.2446 1.2022 4.4003
OCUM-1 GDSC2 3.499 9.5264 -0.3526 13.3337
MKN28 GDSC2 3.7199 6.8587 1.0857 4.5691
SNU-1 GDSC2; CTRP2 3.8988 9.0093 2.5381 19.4194
ECC12 GDSC2 3.9248 7.4545 1.734 7.6514
SNU-5 GDSC2 3.9395 5.3695 1.8443 0.5225
SCH GDSC2 4.0805 9.4033 0.888 13.0523
TMK-1 GDSC2 4.3326 13.6528 -1.0273 21.6486
NUGC-3 GDSC2; CTRP2 4.4057 11.4027 1.9014 20.5425
Hs 746.T GDSC2; CTRP2 5.0088 14.114 1.1171 21.8696
SNU-16 GDSC2; CTRP2 5.1541 6.8546 4.7746 7.3489
SH-10-TC CTRP2 5.3841 8.2747 4.3404 8.5477
KE-39 CTRP2 5.6463 13.4008 2.0294 17.2893
MKN7 GDSC2; CTRP2 5.6703 11.6009 2.9486 13.6741
LMSU CTRP2 6.1392 11.3532 3.4686 10.6181
KATO III GDSC2; CTRP2 6.2387 8.7337 4.8581 4.6239
MKN74 CTRP2 6.4865 13.713 2.572 13.5657
SNG-M GDSC2; CTRP2 5.5055 7.5913 4.7861 6.4303
SNU-685 CTRP2 6.1327 9.3735 4.4528 6.5211
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 2.4122 7.1036 0.0059 14.2115
CAL-62 GDSC2 3.2005 5.7043 1.295 4.3465
BHT-101 GDSC2 3.5434 7.5008 0.6662 7.3826
ASH-3 GDSC2 3.5458 5.5564 1.5748 2.1404
8305C GDSC2 3.6286 8.831 0.0816 10.6038
WRO GDSC2 3.6953 6.427 1.2696 3.5688
SW579 CTRP2 3.7757 8.8204 2.498 19.8955
TT GDSC2 4.1336 6.1721 1.6153 1.2353
CGTH-W-1 GDSC2 4.4964 5.9284 1.8587 0.2286
B-CPAP GDSC2 4.5112 6.4115 1.6887 0.6643
IHH-4 GDSC2 4.5194 5.9577 1.8569 0.225
KMH-2 GDSC2 4.6957 7.0413 2.4439 2.6118
HTC-C3 GDSC2 4.7439 6.7618 1.6531 0.6369
8505C GDSC2 5.3141 7.0107 1.7787 0.1592
ML-1 [Human leukemia] GDSC2; CTRP2 5.6084 8.4201 4.4761 7.4846
TT2609-C02 GDSC2; CTRP2 6.2003 13.0684 2.6615 13.7593
FTC-238 CTRP2 6.2934 8.794 4.8712 4.4711
FTC-133 GDSC2; CTRP2 6.5218 8.2781 5.296 2.335
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 GDSC2; CTRP2 -8.702 6.6876 -10.229 72.1323
DOK GDSC2 -0.2016 4.1322 -1.0742 29.7324
BB49-HNC GDSC2 0.4095 5.1998 -0.9103 26.2632
JHU-011 GDSC2 0.9263 9.6436 -2.0048 35.8953
CAL-33 GDSC2; CTRP2 0.9439 3.984 0.8762 34.2013
NCI-H3118 GDSC2 1.6299 7.3315 -0.7806 21.0324
HSC-2 GDSC2; CTRP2 1.9087 3.0794 1.9083 27.5538
BICR 56 CTRP2 2.0272 7.889 1.0476 30.0376
PE/CA-PJ34 (clone C12) CTRP2 2.1238 7.0892 1.4408 28.4549
HO-1-u-1 GDSC2 2.1868 4.4104 1.163 7.7397
BB30-HNC GDSC2 2.2562 4.7667 1.5929 14.494
PCI-15A GDSC2 2.3285 4.6336 1.7261 13.4178
Detroit 562 GDSC2 2.4907 5.321 0.9607 8.1356
JHU-029 GDSC2 2.5242 6.0852 1.2298 15.7071
SAT [Human HNSCC] GDSC2 2.56 7.6242 -0.1335 14.5935
JHU-022 GDSC2 2.5686 6.911 0.2296 12.435
LB771-HNC GDSC2 2.5835 5.2328 1.0783 7.1429
SAS GDSC2 2.5959 5.0373 1.1852 6.4377
KON GDSC2 2.5994 9.9477 -0.6109 25.0313
BICR 22 GDSC2; CTRP2 2.66 6.8633 2.0987 24.5246
BICR 10 GDSC2 2.7229 7.0316 0.2923 11.6314
HO-1-N-1 GDSC2 2.7284 6.3671 0.6273 9.5729
HSC-3 GDSC2 2.7689 9.6576 -0.9804 18.5283
Ca9-22 GDSC2 2.8263 6.5395 0.6173 9.3776
BICR 31 GDSC2; CTRP2 3.1244 7.6747 2.3009 22.4274
PE/CA-PJ41 (clone D2) CTRP2 3.1346 11.3489 0.6991 27.8371
PCI-30 GDSC2 3.1399 5.7972 1.2097 4.9873
CAL-27 GDSC2; CTRP2 3.2572 6.4183 2.8929 19.8568
PE/CA-PJ49 CTRP2 3.2586 9.1406 1.828 23.7695
OSC-19 GDSC2 3.3128 6.1036 1.9235 8.8759
PCI-06A GDSC2 3.4287 8.1538 0.9944 14.2308
BICR 78 GDSC2 3.4973 7.3318 0.716 7.1865
SCC-15 GDSC2 3.5033 6.4909 1.1205 4.7758
YD-8 CTRP2 3.7805 8.0605 2.8341 18.5953
SCC-9 GDSC2; CTRP2 3.808 9.412 2.2636 20.6978
BICR 18 CTRP2 3.9436 8.8977 2.6337 18.9354
PE/CA-PJ15 GDSC2; CTRP2 3.9779 8.4114 2.8857 17.8698
OSC-20 GDSC2 4.2373 6.952 1.341 2.385
PCI-04B GDSC2 4.3368 11.6597 -0.0343 15.9674
HSC-4 GDSC2; CTRP2 4.3837 9.5561 2.7664 17.3048
KOSC-2 GDSC2 4.4852 12.2256 -0.2015 17.6764
BICR 16 CTRP2 4.4886 9.0281 3.1175 15.6557
SKN-3 GDSC2 4.6189 7.4384 1.3296 1.9871
BHY GDSC2 4.9767 9.8309 1.3218 8.4686
UPCI-SCC-090 GDSC2 5.1311 7.594 1.5002 0.8819
BICR 6 CTRP2 5.2367 10.8116 2.9583 14.5575
FaDu GDSC2; CTRP2 5.3235 11.1414 2.8728 14.7117
SCC-4 GDSC2; CTRP2 6.489 12.8643 2.9975 11.8806
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 GDSC2 0.7367 4.0238 -0.0511 20.3203
BC-3C CTRP2 2.3215 7.9648 1.3331 28.1998
U-BLC1 CTRP2 2.3467 6.1411 1.9822 25.8963
BFTC-905 GDSC2 2.6307 5.1144 1.1739 6.4179
UM-UC-1 CTRP2 3.2818 8.5955 2.0882 22.7652
KMBC-2 CTRP2 3.297 10.5702 1.2213 25.7483
5637 GDSC2 3.677 6.8097 1.0817 4.6715
SW1710 GDSC2 3.7278 5.5792 1.662 1.4603
TCCSUP GDSC2 3.7806 7.59 0.7817 6.213
KU-19-19 GDSC2 3.9226 5.3331 1.8509 0.5115
639V GDSC2 3.9825 5.264 1.901 0.3301
SW780 GDSC2 4.3376 6.4969 1.5795 1.1929
SCaBER CTRP2 4.6376 10.5679 2.5248 17.6377
J82 GDSC2; CTRP2 5.3581 12.7367 2.1104 17.5981
RT-112 GDSC2; CTRP2 5.5225 12.025 2.6088 15.3341
HT-1197 GDSC2; CTRP2 5.6851 12.0023 2.761 14.3938
647V GDSC2; CTRP2 5.688 8.2606 4.6268 6.684
UM-UC-3 GDSC2; CTRP2 6.1156 10.665 3.7932 9.3167
T24 GDSC2; CTRP2 6.6784 11.7859 3.6833 8.7477
RT-4 GDSC2; CTRP2 7.1405 13.3224 3.2736 9.6336
HT-1376 GDSC2; CTRP2 7.2429 10.6232 4.6602 3.8704
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC2 0.4864 4.1461 -0.3621 23.0873
BPH-1 GDSC2 1.1979 6.3107 -0.6723 21.9833
OMC-1 [Human cervical carcinoma] GDSC2 1.6345 4.2919 1.1477 19.6072
ME-180 GDSC2 1.8062 6.5205 -0.2212 17.4049
OVCA420 GDSC2 1.9271 5.4217 0.4319 13.1273
SW954 GDSC2 2.5298 7.1171 0.7296 18.6141
NT2-D1 GDSC2 2.6758 7.3298 0.1065 12.8694
PA-1 GDSC2 2.7046 7.4855 0.0517 13.1125
Ca Ski GDSC2 2.8652 5.2964 1.2595 5.3013
OVMIU GDSC2 2.8778 8.2261 -0.1807 13.979
SKG-IIIa GDSC2 3.0929 6.5175 0.8268 7.4303
LB831-BLC GDSC2 3.1151 5.8542 1.1651 5.3119
UWB1.289 GDSC2 3.2378 10.1369 -0.156 20.9397
KGN GDSC2 3.256 10.2042 -0.8704 16.6589
DSH1 GDSC2 3.263 6.4833 0.9637 6.2094
OVCA433 GDSC2 3.2696 7.0692 1.4045 12.2367
NEC8 GDSC2 3.4328 5.7402 1.4259 3.1408
NCC-IT GDSC2 3.5551 10.6997 -0.8889 15.9874
HEC-1 GDSC2 3.6682 5.2819 1.7564 1.0932
JHOS-3 GDSC2 3.6914 8.5474 1.0104 13.3905
SKN GDSC2 3.7227 6.1286 1.4203 2.697
OV17R GDSC2 3.731 9.4399 0.5968 15.6244
SW756 GDSC2 3.7381 7.3159 0.8835 5.7042
ACC-OV7 GDSC2 3.8136 13.1149 -1.1711 23.6013
DoTc2 4510 GDSC2 3.8474 6.5369 1.309 3.104
JEG-3 GDSC2 3.9882 10.6896 0.1776 17.1304
PEO1 GDSC2 4.0083 9.4462 0.0483 9.9448
PWR-1E GDSC2 4.0393 6.0129 1.6353 1.2425
JAR GDSC2 4.1038 6.7121 2.2259 4.967
C-4-I GDSC2 4.3349 6.4118 1.6122 1.0655
SiHa GDSC2 4.5262 5.7028 1.9464 0.0869
HEY GDSC2 4.605 7.0848 1.4674 1.4066
MS751 GDSC2 4.6167 6.9859 1.5122 1.2169
TC-YIK GDSC2 4.6729 6.5365 1.7079 0.5164
C-33 A GDSC2 5.0727 6.9396 1.7164 0.3284
HT-3 GDSC2 5.1396 7.0676 1.6962 0.348
SiSo GDSC2 5.278 7.3147 1.6605 0.3757
SW962 GDSC2 6.3099 8.2148 2.7073 0.2728
HeLa GDSC2; CTRP2 7.7448 8.4587 5.8183 0.0115
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Alpelisib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Moderate Increased metabolism of Alpelisib caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [6]
Ag-221 DMS0ZBI Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Ag-221. BCR-ABL1-negative chronic myeloid leukaemia [2A41] [7]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Alpelisib caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [6]
Ripretinib DM958QB Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [7]
MK-1439 DM215WE Moderate Increased metabolism of Alpelisib caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [6]
PF-06463922 DMKM7EW Moderate Increased metabolism of Alpelisib caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [6]
Ubrogepant DM749I3 Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Ubrogepant. Migraine [8A80] [8]
Rimegepant DMHOAUG Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Rimegepant. Migraine [8A80] [9]
Siponimod DM2R86O Moderate Increased metabolism of Alpelisib caused by Siponimod mediated induction of CYP450 enzyme. Multiple sclerosis [8A40] [6]
Lefamulin DME6G97 Moderate Decreased metabolism of Alpelisib caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [10]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Alpelisib caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [6]
Larotrectinib DM26CQR Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [7]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [11]
Betrixaban DM2C4RF Moderate Decreased clearance of Alpelisib due to the transporter inhibition by Betrixaban. Venous thromboembolism [BD72] [12]
⏷ Show the Full List of 14 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Ferric oxide black E00522 16211978 Colorant
Hypromellose E00634 Not Available Coating agent
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Alpelisib 50mg tablet 50mg Tablet Oral
Alpelisib 150mg tablet 150mg Tablet Oral
Alpelisib 200mg tablet 200mg Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7955).
3 Teramura T, Watanabe T, Higuchi S, Hashimoto K: Metabolism and pharmacokinetics of barnidipine hydrochloride, a calcium channel blocker, in man following oral administration of its sustained release formulation. Xenobiotica. 1997 Feb;27(2):203-16. doi: 10.1080/004982597240695 .
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Comparison of 19F NMR and 14C measurements for the assessment of ADME of BYL719 (Alpelisib) in humans. Drug Metab Dispos. 2017 Aug;45(8):900-907.
6 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
9 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
10 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
11 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
12 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.