Details of the Drug

General Information of Drug (ID: DMEXZQ2)

Drug Name

QPX7728

Synonyms

Xeruborbactam; Xeruborbactam [INN]; 2170834-63-4; DE79L822UY; UNII-DE79L822UY; CHEMBL4633785; Benzo(E)cycloprop(C)(1,2)oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7B-tetrahydro-2-hydroxy-, (1aR,7bS)-; QPX7728; EX-A7712; QPX-7728; BDBM50541448; AKOS040735994; PD193971; HY-136069; CS-0119486

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 1	[1]
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Drug Type

Small molecule

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C10H8BFO4
Canonical SMILES: B1(C2CC2C3=C(O1)C(=C(C=C3)F)C(=O)O)O
InChI: InChI=1S/C10H8BFO4/c12-7-2-1-4-5-3-6(5)11(15)16-9(4)8(7)10(13)14/h1-2,5-6,15H,3H2,(H,13,14)/t5-,6-/m1/s1
InChIKey: KOHUFVUIYUCFNG-PHDIDXHHSA-N

Cross-matching ID

PubChem CID: 140830474
TTD ID: DMQ86J

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05072444) A Phase 1, Randomized, Double-Blind, Single-Dose, Drug-Drug Interaction Study to Determine the Impact of Co-administration of QPX7728 on the Pharmacokinetics of QPX2014 in Healthy Adult Subjects. U.S.National Institutes of Health.
2	QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics. Front Microbiol. 2021 Jul 5;12:697180.