Details of the Drug

General Information of Drug (ID: DMF38M5)

• Drug Name: 4-Bromo-N-hydroxy-benzamide
• Synonyms: 4-Bromo-N-hydroxybenzamide; 4-Bromo-N-hydroxy-benzamide; 1836-27-7; CHEMBL351337; 4-bromobenzenecarbohydroxamic acid; p-Bromobenzohydroxamic acid; AC1LCOKZ; N-Hydroxy-4-bromobenzamide; p-bromophenylhydroxamic acid; 4-Bromo-N-hydroxybenzamide #; SCHEMBL8575405; Benzamide, 4-bromo-N-hydroxy-; CTK0E2598; DTXSID20345349; VESPFSJNQMGUCQ-UHFFFAOYSA-N; MolPort-002-985-506; ZINC5249551; STK249669; BDBM50015106; AKOS000175576; MCULE-4510290140; DA-16649; SC-53612; KB-290158; ST51029575; FT-0708429

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 216.03
  Logarithm of the Partition Coefficient (xlogp); 1
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C7H6BrNO2
  IUPAC Name: 4-bromo-N-hydroxybenzamide
  Canonical SMILES: C1=CC(=CC=C1C(=O)NO)Br
  InChI: InChI=1S/C7H6BrNO2/c8-6-3-1-5(2-4-6)7(10)9-11/h1-4,11H,(H,9,10)
  InChIKey: VESPFSJNQMGUCQ-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 603910
  CAS Number: 1836-27-7
  TTD ID: D0J7AM
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

References

• [1] Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8.