Details of the Drug

General Information of Drug (ID: DMFI7A8)

Drug Name
6-Benzyloxy-9H-purin-2-ylamine
Synonyms
6-O-Benzylguanine; 19916-73-5; 6-(Benzyloxy)-7H-purin-2-amine; 2-amino-6-benzyloxypurine; 6-(benzyloxy)-9H-purin-2-amine; 2-Amino-6-(benzyloxy)purine; O(6)-Bgua; 6-(Benzyloxy)guanine; 6-Benzyloxyguanine; 6-Benzyloxy guanine; 6-(Phenylmethoxy)-1H-purin-2-amine; 2-Amino-6-(phenylmethoxy)-9H-purine; O6-BG; UNII-01KC87F8FE; 1H-Purin-2-amine, 6-(phenylmethoxy)-; 6-BENZYLGUANINE; Purine, 2-amino-6-(benzyloxy)-; NSC 637037; CHEMBL407874; 01KC87F8FE; 6-benzyloxy-7H-purin-2-amine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 241.25
Logarithm of the Partition Coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C12H11N5O
IUPAC Name
6-phenylmethoxy-7H-purin-2-amine
Canonical SMILES
C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N
InChI
InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChIKey
KRWMERLEINMZFT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4578
CAS Number
19916-73-5
UNII
01KC87F8FE
DrugBank ID
DB11919
TTD ID
D0B5BG
INTEDE ID
DR0022

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
O-6-methylguanine-DNA-alkyltransferase (MGMT) TTJ8DV7 MGMT_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [2]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Regulation of Drug Effects [3]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Drug Response [4]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Regulation of Drug Effects [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
O-6-methylguanine-DNA-alkyltransferase (MGMT) DTT MGMT 1.21E-12 -0.31 -0.83
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.8975 7.1416 5.3691 3.1355
JM1 CTRP2 5.7507 8.4012 4.6131 6.6079
DND-41 CTRP2 4.0788 8.5029 2.948 17.3636
BDCM CTRP2 4.261 14.8041 0.102 26.6793
697 CTRP2 5.0056 7.4612 4.3553 9.3975
SEM CTRP2 5.1922 6.5289 4.9485 6.5701
F-36P CTRP2 5.3751 8.9735 3.9905 10.0168
SET-2 CTRP2 5.4151 6.6577 5.1294 5.263
HH [Human lymphoma] CTRP2 5.4394 8.6106 4.2278 8.8892
L-428 CTRP2 5.4952 9.7962 3.6932 10.9887
Kasumi-1 CTRP2 5.5021 9.3725 3.9093 10.0761
A4/Fukuda CTRP2 5.5407 7.0047 5.0995 5.0645
Mino CTRP2 5.7586 6.6373 5.4857 2.9653
DB CTRP2 5.7919 7.6291 5.0329 4.7656
AML-193 CTRP2 5.8027 9.5463 4.0882 8.6996
MOTN-1 CTRP2 5.8339 8.7552 4.5098 6.8685
RPMI-6666 CTRP2 5.8399 7.882 4.9501 5.0105
Karpas-422 CTRP2 5.8553 7.859 4.975 4.8738
SIG-M5 CTRP2 5.8758 7.6994 5.0725 4.4226
Kasumi-2 CTRP2 5.9035 9.2925 4.3015 7.6017
OCI-Ly19 CTRP2 5.9134 8.0671 4.9219 4.9771
M-07e CTRP2 5.9199 9.4358 4.2438 7.8113
CMK CTRP2 5.9212 6.9765 5.4721 2.6543
NU-DHL-1 CTRP2 5.9246 7.8181 5.0558 4.3927
Daudi CTRP2 5.9249 7.919 5.0057 4.6022
ST486 CTRP2 5.9332 8.4972 4.7241 5.7679
HuNS1 CTRP2 5.9389 8.6444 4.6554 6.0451
LP-1 CTRP2 5.9578 9.5828 4.2025 7.9097
MOLP-8 CTRP2 5.9724 9.7477 4.1324 8.1749
MJ CTRP2 6.0176 7.8597 5.1143 3.9616
TF-1 CTRP2 6.0299 6.7804 5.6642 1.6262
HEL 92.1.7 CTRP2 6.0431 7.9861 5.0725 4.0878
OCI-AML-3 CTRP2 6.0477 7.0773 5.5307 2.1531
Namalwa CTRP2 6.0638 7.7688 5.1983 3.5194
HuT 78 CTRP2 6.065 10.7472 3.7101 9.7598
HD-MY-Z CTRP2 6.0653 7.464 5.3519 2.8708
SUP-B15 CTRP2 6.0896 7.722 5.2429 3.2828
JeKo-1 CTRP2 6.1067 7.1853 5.525 2.0659
Hs 611.T CTRP2 6.1118 7.9212 5.1616 3.5828
U266B1 CTRP2 6.1284 10.6804 3.796 9.2805
OCI-Ly3 CTRP2 6.1482 7.3724 5.4648 2.243
SUP-HD1 CTRP2 6.17 8.2339 5.0525 3.9332
KO52 CTRP2 6.1894 8.9502 4.7105 5.3329
JJN-3 CTRP2 6.2134 10.9207 3.7456 9.3292
HL-60 CTRP2 6.3091 8.7243 4.9181 4.2471
K-562 CTRP2 6.3395 8.0798 5.261 2.7653
CA46 CTRP2 6.3455 8.1758 5.2181 2.9337
BL-70 CTRP2 6.3579 7.7741 5.4248 2.0579
Granta-519 CTRP2 6.4633 8.8526 4.9723 3.7597
EJM CTRP2 6.4758 8.0723 5.3636 2.1286
RL CTRP2 6.602 8.4316 5.2774 2.2932
OCI-M1 CTRP2 6.695 8.2507 5.4248 1.5838
Ci-1 CTRP2 7.2115 7.9314 5.8127 0.0611
OCI-AML-5 CTRP2 7.3736 12.4136 3.888 6.785
Toledo CTRP2 7.7791 12.9903 3.8891 6.1939
KMS-20 CTRP2 13.1092 37.763 -4.383 22.1428
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 5.5819 8.6198 4.3535 8.0535
TE-11 CTRP2 6.0209 8.6581 4.7179 5.6212
TE-14 CTRP2 6.2576 8.0495 5.2135 3.1023
TE-5 CTRP2 6.2715 7.8457 5.3253 2.6117
OE21 CTRP2 6.4181 8.6257 5.0504 3.5099
EC-GI-10 CTRP2 6.6633 9.7516 4.6779 4.654
KYSE-150 CTRP2 6.7459 8.0968 5.5271 1.1357
KYSE-450 CTRP2 6.9747 9.7145 4.9148 3.2242
KYSE-520 CTRP2 7.0671 9.6918 4.9863 2.8174
KYSE-510 CTRP2 7.0922 8.8824 5.3742 1.3246
KYSE-30 CTRP2 7.1909 9.2134 5.2826 1.551
OE33 CTRP2 7.7636 10.0854 5.2129 1.2632
OE19 CTRP2 10.6734 20.8918 2.0323 9.2936
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.745 8.5642 5.3096 1.9693
Hs 766T CTRP2 6.1697 7.3642 5.4858 2.1172
MIA PaCa-2 CTRP2 6.4877 7.7774 5.5137 1.5061
SW1990 CTRP2 6.605 8.3424 5.3224 2.1081
PaTu 8988s CTRP2 6.7523 9.3676 4.9294 3.4841
AsPC-1 CTRP2 6.7865 8.8116 5.2196 2.2689
KP-2 CTRP2 6.8068 8.7452 5.2642 2.0668
DAN-G CTRP2 6.903 9.6013 4.9206 3.3008
PK-45H CTRP2 6.9395 9.0507 5.2057 2.1259
PaTu 8988t CTRP2 7.0071 9.8094 4.8911 3.2738
Panc 10.05 CTRP2 7.0139 9.3575 5.1093 2.4059
Panc 08.13 CTRP2 7.0524 9.7384 4.9547 2.9609
PSN1 CTRP2 7.074 11.3313 4.2021 5.9649
Capan-1 CTRP2 7.1972 9.1138 5.3306 1.3739
Panc 02.03 CTRP2 7.2466 9.4166 5.2235 1.7062
Capan-2 CTRP2 7.3609 9.8446 5.097 2.0451
Panc 04.03 CTRP2 7.4844 10.8087 4.7287 3.2903
Panc 03.27 CTRP2 7.5436 11.2957 4.5383 3.9535
HuP-T3 CTRP2 7.6489 9.2826 5.4872 0.5417
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.2129 8.926 4.7415 5.5423
Hs 940.T CTRP2 4.841 7.7339 4.0657 10.9743
RVH-421 CTRP2 5.3365 9.642 3.6262 11.6101
WM115 CTRP2 6.0679 7.2974 5.4373 2.5067
COLO 792 CTRP2 6.1534 7.9441 5.1838 3.4124
Hs 895.T CTRP2 6.197 7.2695 5.5539 1.7854
HMCB CTRP2 6.2099 7.1849 5.6055 1.5491
LOX-IMVI CTRP2 6.2139 7.4282 5.4882 2.0305
MeWo CTRP2 6.2429 10.5127 3.9735 8.3241
IGR-39 CTRP2 6.391 7.8989 5.3877 2.159
WM266-4 CTRP2 6.3954 8.2395 5.2239 2.8277
COLO 800 CTRP2 6.4072 8.1837 5.26 2.6596
UACC-62 CTRP2 6.4129 8.9072 4.9074 4.1136
WT2-iPS CTRP2 6.4138 7.7361 5.4831 1.7343
SK-MEL-3 CTRP2 6.4149 8.1115 5.301 2.478
CJM [Human melanoma] CTRP2 6.4205 7.8054 5.4542 1.8419
Hs 839.T CTRP2 6.4253 8.7771 4.981 3.7862
HT-144 CTRP2 6.4902 8.121 5.3501 2.1621
SK-MEL-24 CTRP2 6.5332 8.4974 5.1975 2.7198
WM88 CTRP2 6.5422 8.4463 5.2288 2.5783
Hs 294T CTRP2 6.5457 8.9939 4.9637 3.6617
IGR-1 CTRP2 6.6136 7.9765 5.5015 1.3887
Hs 688(A).T CTRP2 6.7185 10.124 4.5355 5.1534
A2058 CTRP2 6.738 8.5781 5.2985 2.022
UACC-257 CTRP2 6.781 9.0057 5.1235 2.6585
COLO 829 CTRP2 6.8074 13.3938 2.9846 11.3587
IGR-37 CTRP2 6.8125 8.2368 5.5029 1.152
K029AX CTRP2 6.8127 8.8098 5.2376 2.1634
SK-MEL-2 CTRP2 7.1816 8.0485 5.7601 0.1432
A101D CTRP2 7.2204 13.8632 3.0665 10.3273
WM983B CTRP2 7.2443 10.4029 4.7657 3.4521
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 6.6507 9.6735 4.707 4.5538
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-BE(2) CTRP2 5.9212 8.0678 4.9283 4.9346
SK-N-FI CTRP2 6.0606 8.156 5.0021 4.3501
CHP-212 CTRP2 6.18 7.7156 5.3189 2.7977
SK-N-SH CTRP2 6.4823 7.9356 5.4341 1.8329
SK-N-AS CTRP2 6.4881 8.2993 5.2619 2.5252
NH-6 CTRP2 6.6038 8.581 5.2066 2.5772
KP-N-YN CTRP2 7.3198 9.676 5.1492 1.8985
SK-N-DZ CTRP2 7.4715 9.004 5.5172 0.5648
IMR-32 CTRP2 7.6721 8.7538 5.6942 0.1181
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 6.9764 8.9178 5.2901 1.759
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 888.T CTRP2 5.7946 8.3895 4.6576 6.3299
SK-ES-1 CTRP2 5.8002 8.3562 4.6792 6.2277
A-673 CTRP2 6.0705 7.2412 5.4676 2.3746
Hs 822.T CTRP2 6.256 9.4561 4.5115 6.0461
SK-N-MC CTRP2 6.2794 8.5528 4.9803 4.0395
SaOS-2 CTRP2 6.4521 8.6656 5.0561 3.4307
TC71 CTRP2 6.4523 11.6846 3.5566 9.6716
MG-63 CTRP2 6.9192 10.0396 4.7205 4.0857
G-292 clone A141B1 CTRP2 6.9259 9.7941 4.8436 3.5782
HOS CTRP2 6.9983 9.5217 5.022 2.7676
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BT-474 CTRP2 4.3575 8.78 3.1029 16.0405
Hs 578Bst CTRP2 5.8875 9.7227 4.0729 8.5922
HCC1500 CTRP2 6.2232 7.9345 5.2439 3.035
MDA-MB-453 CTRP2 6.3023 8.2097 5.1685 3.213
HCC1419 CTRP2 6.3242 9.1514 4.7174 5.0606
MDA-MB-157 CTRP2 6.3564 9.0704 4.7829 4.7302
SK-BR-3 CTRP2 6.4099 8.6088 5.0526 3.5146
BT-549 CTRP2 6.4403 8.6417 5.0591 3.4374
HCC2218 CTRP2 6.4403 8.8099 4.9762 3.7815
AU565 CTRP2 6.4431 8.7503 5.0076 3.6462
CAL-85-1 CTRP2 6.4728 11.4069 3.7112 8.9954
UACC-812 CTRP2 6.5132 8.114 5.3695 2.0496
HCC202 CTRP2 6.5155 8.3244 5.2691 2.454
T-47D CTRP2 6.632 12.5883 3.2483 10.6097
HCC1428 CTRP2 6.6445 8.0745 5.4752 1.4519
BT-20 CTRP2 6.7287 8.6235 5.2708 2.1436
MDA-MB-415 CTRP2 6.889 9.1838 5.1105 2.5635
MDA-MB-361 CTRP2 7.1221 8.8659 5.3983 1.21
ZR-75-30 CTRP2 7.5427 9.2525 5.4503 0.7056
HCC38 CTRP2 7.7096 10.7076 4.9108 2.3506
BT 139 CTRP2 4.3105 10.1069 2.4342 18.776
BT 159 CTRP2 5.834 8.2572 4.7581 5.827
BT 248 CTRP2 6.129 8.2203 5.0261 4.1196
BT 271 CTRP2 6.2507 8.9922 4.7387 5.1029
BT 245 CTRP2 6.3778 8.9859 4.8414 4.4485
BT 444 CTRP2 6.4336 7.9251 5.4054 2.0213
BT 112 CTRP2 6.4438 8.4572 5.1525 3.045
BT 216 CTRP2 6.4459 8.0842 5.3367 2.2835
BT164 CTRP2 6.4523 8.2577 5.2566 2.6024
BT 416 CTRP2 6.456 9.5299 4.6317 5.1895
BT 340 CTRP2 6.4588 8.3863 5.1983 2.8321
BT 428 CTRP2 6.4791 8.4528 5.1804 2.8736
BT 231 CTRP2 6.4988 10.2234 4.3205 6.4139
BT 504 CTRP2 6.5147 8.5023 5.1819 2.8122
BT 330 CTRP2 6.5184 8.4045 5.2323 2.6002
BT 131 CTRP2 6.5214 9.0812 4.9029 3.9525
BT147 CTRP2 6.5666 8.3866 5.2748 2.3553
BT 359 CTRP2 6.5809 9.9888 4.4995 5.5288
BT 440 CTRP2 6.711 8.3649 5.3815 1.7319
BT 232 CTRP2 6.7352 8.5638 5.3034 2.0062
BT 172 CTRP2 6.7556 8.3465 5.4183 1.5342
BT 224 CTRP2 6.8381 8.4915 5.402 1.498
BT 328 CTRP2 6.8562 9.649 4.8656 3.5899
BT 333 CTRP2 6.8597 9.2113 5.078 2.7317
BT 187 CTRP2 6.8808 11.7281 3.8659 7.6525
BT 286 CTRP2 6.8816 8.7981 5.287 1.884
BT 422 CTRP2 6.9073 9.8645 4.7969 3.7937
BT 482 CTRP2 6.9405 8.803 5.3211 1.6841
BT 320 CTRP2 6.9617 9.8261 4.8526 3.4914
BT 145 CTRP2 7.007 9.9291 4.8339 3.5028
BT 498 CTRP2 7.2879 8.5317 5.6214 0.3975
BT 239 CTRP2 7.4628 15.095 2.6399 11.5913
BT 228 CTRP2 8.0006 14.2281 3.4457 7.6274
BT 179 CTRP2 8.0187 12.9399 4.0704 5.1632
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KG-1-C CTRP2 5.9904 9.5198 4.2615 7.598
D283 Med CTRP2 6.1169 7.8522 5.2002 3.4109
Hs 683 CTRP2 6.2764 7.5383 5.4809 1.9569
CCF-STTG1 CTRP2 6.3126 7.3078 5.6199 1.3284
DK-MG CTRP2 6.3248 7.8557 5.3605 2.3768
42-MG-BA CTRP2 6.3445 8.6197 4.9975 3.8545
GOS-3 CTRP2 6.3928 7.7911 5.4416 1.9353
GMS-10 CTRP2 6.4236 8.0976 5.3141 2.4107
SNB-75 CTRP2 6.5236 8.93 4.9789 3.6344
TM-31 CTRP2 6.5267 7.7596 5.5477 1.3196
Becker CTRP2 6.5439 9.5407 4.6931 4.7857
8-MG-BA CTRP2 6.5734 8.7581 5.0992 3.0608
YKG-1 CTRP2 6.592 7.8698 5.5377 1.2757
SW1783 CTRP2 6.5982 15.663 1.6885 16.6434
YH-13 CTRP2 6.6029 9.6 4.7079 4.6273
SF539 CTRP2 6.6046 10.3877 4.3201 6.2346
M059K CTRP2 6.6204 8.3855 5.3122 2.1275
KNS-42 CTRP2 6.6984 8.6588 5.2339 2.3319
SF268 CTRP2 6.7835 10.8816 4.2108 6.3903
A-172 CTRP2 6.8914 8.5537 5.4056 1.4237
U-118MG CTRP2 6.9947 9.6702 4.9492 3.0601
U-251MG CTRP2 7.0812 10.8065 4.4622 4.895
T98G CTRP2 7.1421 8.8641 5.4101 1.1502
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-7 CTRP2 6.114 7.827 5.2104 3.3736
AN3-CA CTRP2 6.2861 8.9339 4.7958 4.8
MFE-296 CTRP2 6.4984 8.7048 5.071 3.2943
JHUEM-3 CTRP2 6.5219 8.5585 5.1597 2.8922
ESS-1 CTRP2 6.6626 8.6983 5.1906 2.5562
HEC-1-A CTRP2 6.787 8.8893 5.1831 2.4131
EN CTRP2 6.8526 9.3759 4.9945 3.0753
JHUEM-1 CTRP2 6.9011 9.3987 5.0163 2.9207
MFE-319 CTRP2 6.9853 10.1343 4.7206 3.9892
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 CTRP2 5.8094 7.5814 5.0722 4.5638
UO-31 CTRP2 6.1066 10.809 3.7137 9.6649
ACHN CTRP2 6.3888 8.3275 5.1756 3.0384
VMRC-RCZ CTRP2 6.5111 9.3352 4.7699 4.5212
TUHR14TKB CTRP2 6.526 8.9919 4.9502 3.7489
Caki-2 CTRP2 6.5797 8.3112 5.3202 2.1528
KMRC-1 CTRP2 6.6383 9.1944 4.9327 3.6438
Caki-1 CTRP2 6.6473 9.3788 4.849 3.9736
KMRC-2 CTRP2 6.7591 9.3733 4.9314 3.4657
786-O CTRP2 6.7812 8.3904 5.4138 1.5206
RCC10RGB CTRP2 7.0989 10.1504 4.7898 3.5518
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 15 CTRP2 5.5983 6.8325 5.2366 4.3673
NCI-H747 CTRP2 5.7877 12.6658 2.5174 15.1418
COLO 320 CTRP2 5.8337 9.8987 3.939 9.2609
SNU-C1 CTRP2 5.906 8.2726 4.813 5.4493
SW948 CTRP2 5.9979 10.6394 3.7081 9.8988
COLO 678 CTRP2 5.9991 10.0361 4.0107 8.6328
NCI-H716 CTRP2 6.2814 9.4024 4.5586 5.8024
SNU-C4 CTRP2 6.333 7.362 5.6078 1.3473
C2BBe1 CTRP2 6.3437 7.8181 5.3929 2.2119
GP2d CTRP2 6.3471 8.3311 5.1425 3.2454
T84 CTRP2 6.4307 8.6421 5.0518 3.4835
SW1417 CTRP2 6.4974 8.4008 5.2191 2.6862
RCM-1 [Human ESC] CTRP2 6.5328 7.8164 5.5249 1.4012
HCT 8 CTRP2 6.5884 7.9196 5.5121 1.3795
SNU-503 CTRP2 6.7127 10.1184 4.534 5.169
HCC-56 CTRP2 7.182 11.5201 4.1869 5.8626
LS1034 CTRP2 7.5794 9.395 5.4095 0.7983
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-387 CTRP2 6.2503 10.1386 4.1662 7.5038
HuH-1 CTRP2 6.2752 7.3776 5.559 1.6358
JHH-5 CTRP2 6.3587 7.8527 5.387 2.2127
SNU-449 CTRP2 6.4599 8.231 5.275 2.5146
JHH-2 CTRP2 6.5265 9.308 4.7949 4.3919
PLC/PRF/5 CTRP2 6.6766 8.9232 5.0918 2.936
SK-HEP-1 CTRP2 6.6779 8.8961 5.1058 2.8774
JHH-6 CTRP2 6.704 8.909 5.1176 2.7916
SNU-423 CTRP2 6.8087 8.5512 5.3563 1.7071
SNU-475 CTRP2 6.8572 8.3999 5.4553 1.2782
JHH-4 CTRP2 6.9381 15.4984 2.0399 14.7503
HLF CTRP2 6.9557 9.2079 5.1423 2.3514
JHH-1 CTRP2 7.0255 10.2812 4.6774 4.1054
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DMS 53 CTRP2 5.3085 8.9934 3.9193 10.4602
NCI-H1915 CTRP2 5.6058 10.763 3.3103 12.3365
SK-MES-1 CTRP2 5.8758 6.976 5.4315 2.9211
NCI-H1793 CTRP2 5.9677 9.005 4.4997 6.6421
NCI-H1568 CTRP2 5.9717 7.9213 5.0447 4.3444
EKVX CTRP2 5.9829 10.8179 3.6062 10.3515
NCI-H146 CTRP2 6.0012 7.2465 5.407 2.764
NCI-H1563 CTRP2 6.0764 8.9833 4.6015 6.0035
DMS 454 CTRP2 6.0825 9.4805 4.358 7.0148
HOP-92 CTRP2 6.083 9.6097 4.2938 7.2833
NCI-H1944 CTRP2 6.1036 7.4503 5.3902 2.6378
NCI-H1703 CTRP2 6.1407 8.1706 5.0604 3.9537
LUDLU-1 CTRP2 6.1951 7.7649 5.3063 2.8235
NCI-H1694 CTRP2 6.2029 8.6142 4.8891 4.5586
NCI-H810 CTRP2 6.2337 8.2148 5.1127 3.5659
NCI-H2110 CTRP2 6.2374 8.3532 5.0466 3.8359
DV-90 CTRP2 6.2911 8.373 5.0788 3.6069
NCI-H1623 CTRP2 6.2918 8.8061 4.8639 4.5047
NCI-H838 CTRP2 6.3023 8.3136 5.1169 3.4282
NCI-H520 CTRP2 6.3052 8.1503 5.2001 3.0761
VMRC-LCD CTRP2 6.3108 7.775 5.3899 2.2778
COR-L105 CTRP2 6.3151 8.1676 5.1991 3.0635
NCI-H522 CTRP2 6.3354 8.0623 5.2665 2.7493
NCI-H1341 CTRP2 6.3836 8.4451 5.1137 3.3042
DMS 273 CTRP2 6.4209 9.4157 4.6613 5.1263
LC-1/sq-SF CTRP2 6.4334 7.8524 5.4405 1.8788
DMS 114 CTRP2 6.4559 8.3324 5.2226 2.7366
HOP-62 CTRP2 6.4778 9.3815 4.7219 4.7764
NCI-H1693 CTRP2 6.5184 9.1335 4.8749 4.073
NCI-H841 CTRP2 6.5273 10.6624 4.1245 7.1815
LK2 CTRP2 6.6282 7.9253 5.5345 1.2436
NCI-H647 CTRP2 6.6319 9.3269 4.8633 3.9393
RERF-LC-MS CTRP2 6.6339 11.1289 3.9752 7.6175
NCI-H1869 CTRP2 6.6551 10.2119 4.4451 5.6311
NCI-H23 CTRP2 6.707 9.0884 5.033 3.1301
NCI-H1651 CTRP2 6.7101 8.6 5.2697 2.1732
HCC1438 CTRP2 6.7235 9.2022 4.9894 3.2825
NCI-H2342 CTRP2 6.7556 10.143 4.5533 5.0207
RERF-LC-Ad2 CTRP2 6.7708 8.839 5.1962 2.3827
NCI-H2029 CTRP2 6.8945 8.8161 5.2867 1.8695
Lu-65 CTRP2 6.9267 8.5322 5.4361 1.2733
HCC4006 CTRP2 6.9746 8.7575 5.3623 1.4916
ChaGo-K-1 CTRP2 6.9816 9.3231 5.1048 2.4646
NCI-H1339 CTRP2 7.0506 10.3898 4.6423 4.2107
Calu-1 CTRP2 7.0559 8.9523 5.3219 1.5515
COLO 668 CTRP2 7.1519 9.8137 4.9834 2.7205
HCC2935 CTRP2 7.1939 9.8994 4.9699 2.7201
T3M-10 CTRP2 7.2294 9.904 4.99 2.5988
NCI-H1105 CTRP2 7.2536 12.1289 3.9415 6.7507
NCI-H2170 CTRP2 7.2676 11.0541 4.471 4.5909
NCI-H2196 CTRP2 7.3144 8.979 5.4515 0.8656
NCI-H322 CTRP2 7.4644 9.4641 5.3227 1.1561
NCI-H1092 CTRP2 7.6823 9.4328 5.4428 0.6392
NCI-H1395 CTRP2 7.7342 16.2953 2.25 12.6145
KNS-62 CTRP2 7.7743 9.196 5.5739 0.2877
NCI-H2171 CTRP2 8.0009 9.1374 5.68 0.0776
COR-L95 CTRP2 8.338 9.778 5.5803 0.1299
Hs 888.Lu CTRP2 6.0094 9.3946 4.34 7.2313
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 5.9606 8.2572 4.8674 5.1115
COV434 CTRP2 5.6044 8.8611 4.2544 8.4182
OC 314 CTRP2 6.3191 7.5551 5.504 1.7931
EFO-27 CTRP2 6.4939 8.3797 5.2268 2.66
JHOS-2 CTRP2 6.5264 9.4842 4.7078 4.7535
OAW42 CTRP2 6.5859 8.2933 5.3329 2.0928
JHOM-1 CTRP2 6.6228 10.0214 4.515 5.3945
OVCAR-5 CTRP2 6.725 28.6796 -4.7112 31.3352
COV362 CTRP2 6.7706 9.589 4.8348 3.842
EFO-21 CTRP2 6.7792 8.9031 5.1713 2.4705
COV644 CTRP2 6.8199 9.4096 4.956 3.277
OV7 CTRP2 6.8818 10.3043 4.5656 4.7736
OAW28 CTRP2 7.0887 12.4071 3.6859 8.0499
OV56 CTRP2 7.1896 8.9474 5.3996 1.1421
OV-90 CTRP2 7.2141 10.4141 4.7406 3.591
TOV-21G CTRP2 7.5137 9.0428 5.5211 0.5298
TOV-112D CTRP2 7.7388 12.223 4.2273 4.9159
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.0748 10.25 3.9668 8.6696
Aska-SS CTRP2 6.5305 8.1325 5.3725 2.0124
A-204 CTRP2 5.657 8.1705 4.6434 6.682
G-401 CTRP2 5.8816 7.7753 5.0398 4.5478
SW982 CTRP2 6.0778 7.4961 5.3462 2.871
TE 441.T CTRP2 6.0893 8.0606 5.0735 3.9953
TTC-709 CTRP2 6.1298 7.3142 5.4792 2.2158
HT-1080 CTRP2 6.1427 7.2178 5.5375 1.9485
BT-12 CTRP2 6.1467 7.4959 5.402 2.5089
GCT CTRP2 6.1937 8.0794 5.1485 3.4872
MES-SA CTRP2 6.2923 7.5332 5.4952 1.8719
TE 617.T CTRP2 6.301 7.8113 5.3646 2.3985
KYM-1 CTRP2 6.333 9.0998 4.75 4.9088
Tm87-16 CTRP2 6.3504 7.5313 5.5379 1.6058
SK-LMS-1 CTRP2 6.3647 8.4109 5.1163 3.3249
Hs 729.T CTRP2 6.5074 8.9431 4.9605 3.7368
G-402 CTRP2 6.5952 12.0048 3.5098 9.6075
SK-UT-1 CTRP2 7.0781 9.316 5.1688 2.0987
RD CTRP2 7.1682 9.3908 5.1891 1.9179
BT-16 CTRP2 10.4724 26.3322 -0.6883 17.6605
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.3417 7.8541 5.3738 2.2943
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 6.4031 8.2251 5.2367 2.7624
H-STS CTRP2 6.5246 7.9886 5.4375 1.7594
P-STS CTRP2 7.7313 11.7028 4.467 3.9927
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 CTRP2 6.2597 8.732 4.8756 4.5127
JL-1 CTRP2 6.3537 7.5803 5.5165 1.6884
MPP 89 CTRP2 7.8682 9.3771 5.5447 0.3105
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 6.0144 7.6347 5.2241 3.5062
VCaP CTRP2 6.3563 8.0997 5.2637 2.7267
DU145 CTRP2 6.5376 8.5656 5.1675 2.8362
PaCa-3 CTRP2 6.6548 7.9322 5.5477 1.1621
NCI-H660 CTRP2 6.8596 9.288 5.0414 2.8779
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 7.2387 10.5053 4.7135 3.6652
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 5.6838 7.354 5.0692 4.8526
HGC-27 CTRP2 5.7212 7.1283 5.2141 4.1683
KATO III CTRP2 5.8611 9.2179 4.3024 7.6831
SNU-1 CTRP2 5.9904 8.0305 5.006 4.4699
SNU-216 CTRP2 6.0336 8.4291 4.8431 5.0703
KE-39 CTRP2 6.3989 8.6315 5.0331 3.6137
Hs 746.T CTRP2 6.5327 8.0081 5.4336 1.7637
HuG1-N CTRP2 6.5388 11.0712 3.9302 7.9697
SH-10-TC CTRP2 6.5632 8.6097 5.1642 2.8103
LMSU CTRP2 6.6892 9.4238 4.8573 3.8744
MKN74 CTRP2 6.7751 9.0585 5.0942 2.7843
MKN7 CTRP2 7.0741 9.7424 4.967 2.8841
SNU-601 CTRP2 7.1302 9.3991 5.1624 2.0615
IM95 CTRP2 7.3802 9.1426 5.416 0.9256
SNU-685 CTRP2 6.7703 8.7621 5.2325 2.2396
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT2609-C02 CTRP2 6.1066 9.4446 4.3958 6.8098
FTC-238 CTRP2 6.1366 7.4198 5.432 2.4016
SW579 CTRP2 6.1723 7.4197 5.4602 2.2197
FTC-133 CTRP2 6.6353 8.4512 5.2907 2.1925
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ34 (clone C12) CTRP2 6.0454 7.5654 5.2847 3.1912
CAL-33 CTRP2 6.0593 7.4949 5.3315 2.9678
BICR 22 CTRP2 6.1231 7.343 5.4595 2.3109
PE/CA-PJ15 CTRP2 6.1254 7.7865 5.2399 3.2286
BICR 31 CTRP2 6.2101 8.4115 4.996 4.0973
BICR 6 CTRP2 6.2693 8.2077 5.144 3.3725
BICR 16 CTRP2 6.2873 8.1972 5.1632 3.2609
CAL-27 CTRP2 6.3388 7.9472 5.3258 2.4977
SCC-9 CTRP2 6.3851 8.5317 5.0721 3.4747
HSC-2 CTRP2 6.4429 8.1274 5.3134 2.3836
PE/CA-PJ49 CTRP2 6.4771 7.795 5.4982 1.5828
FaDu CTRP2 6.6638 9.8157 4.6467 4.7819
BICR 18 CTRP2 6.6791 8.6313 5.234 2.3585
PE/CA-PJ41 (clone D2) CTRP2 6.7899 9.612 4.8372 3.8032
SCC-4 CTRP2 7.3806 11.8608 4.1604 5.6768
BICR 56 CTRP2 7.3856 11.6756 4.2529 5.2982
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1197 CTRP2 2.5641 20.2791 -9.559 27.2838
BC-3C CTRP2 5.9469 7.9162 5.0261 4.4722
U-BLC1 CTRP2 6.2667 9.5104 4.493 6.1041
UM-UC-1 CTRP2 6.2724 8.4884 5.0068 3.9407
SCaBER CTRP2 6.4003 8.3204 5.1876 2.9699
647V CTRP2 6.4961 8.5394 5.1504 2.9705
T24 CTRP2 6.4965 8.6359 5.1034 3.1637
J82 CTRP2 6.5159 8.0993 5.3784 2.0096
KMBC-2 CTRP2 6.7806 9.1235 5.0668 2.8867
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 6.5115 8.6206 5.1218 3.0643

References

1 Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8.
2 Human liver oxidative metabolism of O6-benzylguanine. Biochem Pharmacol. 1995 Oct 26;50(9):1385-9.
3 In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010 Aug;38(8):1322-7. doi: 10.1124/dmd.110.033555. Epub 2010 May 5.
4 Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. Cancer Res. 2000 Oct 1;60(19):5464-9.
5 Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44.