Details of the Drug

General Information of Drug (ID: DMFMZ3G)

• Drug Name: Choriogonadotropin alfa

Indication

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Approved	[1]

• Therapeutic Class: Fertility Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  G03GA08: Choriogonadotropin alfa
  G03GA: Gonadotropins
  G03G: GONADOTROPINS AND OTHER OVULATION STIMULANTS
  G03: SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
  G: GENITO URINARY SYSTEM AND SEX HORMONES
• Sequence:
  >Alpha chain
  APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCC
  VAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
  >Beta chain
  SKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYR
  DVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSS
  SKAPPPSLPSPSRLPGPSDTPILPQ
• ADMET Property:
  Bioavailability: The bioavailability of drug is 40% []
  Half-life: The concentration or amount of drug in body reduced by one-half in 29 +/- 6 hours [2]
  Vd: The volume of distribution (Vd) of drug is 5.9 +/- 1.0 L []
• Cross-matching ID:
  UNII: 6413W06WR3
  DrugBank ID: DB00097
  TTD ID: D0W6SS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Modulator	[3]

Molecular Expression Atlas of This Drug

• The Studied Disease: Female infertility
• ICD Disease Classification: GA31.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	3.55E-01	5.41E-04	4.54E-03

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.