Details of the Drug

General Information of Drug (ID: DMFNSHM)

• Drug Name: LHF-535
• Synonyms: BET7FM8SQG; UNII-BET7FM8SQG; 1450929-77-7; (Z)-2-(4-(2-(1-(4-Isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol; CHEMBL4537239; SCHEMBL15201523; HY-112762; CS-0063343; 2-[4-[(Z)-2-[1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]ethenyl]phenyl]propan-2-ol; Benzenemethanol, alpha,alpha-dimethyl-4-((1Z)-2-(1-(4-(1-methylethoxy)phenyl)-1H-benzimidazol-5-yl)ethenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Lassa fever	1D61.2	Phase 1	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 412.5
  Logarithm of the Partition Coefficient (xlogp); 5.8
  Rotatable Bond Count (rotbonds); 6
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C27H28N2O2
  IUPAC Name: 2-[4-[(Z)-2-[1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]ethenyl]phenyl]propan-2-ol
  Canonical SMILES: CC(C)OC1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)/C=C\\C4=CC=C(C=C4)C(C)(C)O
  InChI: InChI=1S/C27H28N2O2/c1-19(2)31-24-14-12-23(13-15-24)29-18-28-25-17-21(9-16-26(25)29)6-5-20-7-10-22(11-8-20)27(3,4)30/h5-19,30H,1-4H3/b6-5-
  InChIKey: DBNZTRPIBJSUIX-WAYWQWQTSA-N
• Cross-matching ID:
  PubChem CID: 71711529
  CAS Number: 1450929-77-7
  TTD ID: DY03KH
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lassa virus Pre-glycoprotein polyprotein GP complex (LASV GPC)	TTD2IK3	GLYC_LASSG	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT03993704) Multiple Ascending Oral Dose 14-Day Trial of LHF-535 in Healthy Participants. U.S. National Institutes of Health.
• [2] A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439.