Details of the Drug

General Information of Drug (ID: DMFNUHQ)

Drug Name
8-chloro-quinoline-3-carbonitrile
Synonyms CHEMBL436817; Cyanoquinoline, 11; SCHEMBL6071997; BDBM21898; CHEBI:94979; BRD-K00088062-001-01-3; 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1H-imidazole-5-ylmethyl)amino]-8-chloro-3-quinolinecarbonitrile
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 427.3
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H13Cl2FN6
IUPAC Name
8-chloro-4-(3-chloro-4-fluoroanilino)-6-(1H-imidazol-5-ylmethylamino)quinoline-3-carbonitrile
Canonical SMILES
C1=CC(=C(C=C1NC2=C3C=C(C=C(C3=NC=C2C#N)Cl)NCC4=CN=CN4)Cl)F
InChI
InChI=1S/C20H13Cl2FN6/c21-16-4-12(1-2-18(16)23)29-19-11(6-24)7-27-20-15(19)3-13(5-17(20)22)26-9-14-8-25-10-28-14/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29)
InChIKey
ONXROKMQGCSOMG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
17759555
ChEBI ID
CHEBI:94979
TTD ID
D03MUZ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cot oncogene messenger RNA (MAP3K8 mRNA) TTGECUM M3K8_HUMAN Inhibitor [1]
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 4.626 11.6608 2.4941 23.9008
THP-1 CTRP1 3.4867 4.4172 3.4865 51.0311
KMS-34 CTRP2 3.6148 5.0948 3.6063 22.818
MV4-11 CTRP2 3.8393 5.9987 3.7651 21.5405
Peer CTRP2 3.9015 5.8593 3.8494 22.5283
LP-1 CTRP1 3.9509 7.3473 3.5841 45.4627
KHM-1B CTRP2 3.9626 7.2588 3.6157 24.9552
SU-DHL-8 CTRP2 4.2386 10.0991 2.8166 23.8137
KMS-21-BM CTRP2 4.3161 6.5834 4.1762 18.5827
WSU-DLCL2 CTRP2; CTRP1 4.3853 4.9877 4.3852 17.8372
HDLM-2 CTRP2 4.4035 7.5477 4.0053 18.9366
BL-70 CTRP1 4.4144 9.0103 2.5234 24.269
NOMO-1 CTRP2; CTRP1 4.45 5.7945 4.433 17.4625
OCI-AML-3 CTRP1 4.4851 5.0192 4.4851 36.769
GDM-1 CTRP2; CTRP1 4.5266 6.5425 4.4172 17.2698
SKM-1 CTRP2; CTRP1 4.5428 6.5633 4.4308 17.171
PL21 CTRP2; CTRP1 4.5536 6.5749 4.4401 17.1041
Ki-JK CTRP2 4.5871 5.9818 4.5603 18.854
HT CTRP2; CTRP1 4.6712 7.3462 4.3612 18.0091
RPMI-8402 CTRP2 4.7408 7.1798 4.4877 17.289
EJM CTRP1 4.7495 6.6593 4.6354 33.7767
NALM-6 CTRP2 4.7525 6.8708 4.5849 15.765
KE-37 CTRP2 4.8252 6.8241 4.6756 15.2152
Jurkat CTRP2 4.851 6.5756 4.7581 14.8416
NCO2 CTRP2 4.8953 6.8796 4.7384 14.7727
U-937 CTRP2; CTRP1 4.9242 6.8785 4.776 14.7565
JVM-2 CTRP2 4.9489 6.8361 4.8075 14.3591
Ku812 CTRP2; CTRP1 4.9611 6.4212 4.9039 13.9807
KMS-26 CTRP2 4.98 6.3517 4.9343 13.8147
Ri-1 CTRP2 4.9926 7.8341 4.5425 15.21
JVM-3 CTRP2 5.0603 8.083 4.5206 17.3833
RPMI-8226 CTRP2; CTRP1 5.0678 6.9063 4.9256 13.7779
KM-H2 CTRP2 5.0927 6.9926 4.9246 13.4947
CML-T1 CTRP2 5.1604 6.7126 5.0658 13.6778
KE-97 CTRP2; CTRP1 5.2035 7.3852 4.9277 13.1505
KCL-22 CTRP2 5.2245 6.755 5.1263 12.3639
SU-DHL-1 CTRP2 5.2363 6.509 5.1855 12.9705
EM-2 CTRP2 5.2616 6.3634 5.2325 11.8742
KMS-27 CTRP2 5.2691 6.8001 5.1647 12.0877
PF-382 CTRP2 5.2743 7.8666 4.8323 13.3064
AMO1 CTRP2; CTRP1 5.2836 6.9944 5.1387 12.3497
P31/FUJ CTRP2 5.3164 6.9609 5.177 12.7337
NCI-H929 CTRP2 5.321 6.2636 5.305 11.4324
KMS-18 CTRP2 5.3312 8.3529 4.698 13.6685
SUP-T11 CTRP2 5.3668 7.373 5.109 11.9949
EHEB CTRP2 5.4018 6.816 5.3056 12.8614
Karpas-299 CTRP2 5.4021 7.705 4.6327 7.8432
MOLM-13 CTRP2 5.4072 7.0483 5.2526 11.3457
DEL CTRP2 5.4507 7.6429 5.1051 11.7662
OCI-AML-2 CTRP2 5.4948 7.6851 4.7306 7.1789
SUP-T1 CTRP2 5.5064 8.0609 5.0021 12.0062
SU-DHL-5 CTRP1 5.5721 5.9893 5.5719 21.2411
LAMA-84 CTRP2 5.5731 7.0389 5.4362 10.1738
NU-DUL-1 CTRP2; CTRP1 5.5945 6.5044 5.571 9.849
P12-Ichikawa CTRP2 5.6135 7.9856 5.1457 11.1547
L-1236 CTRP2 5.6765 10.2151 4.2013 14.7774
KMS-11 CTRP2; CTRP1 5.687 10.0457 4.3104 14.5118
MOLT-16 CTRP2 5.7398 6.9221 5.6487 8.8952
BV-173 CTRP2 5.7563 8.6668 5.0007 11.3493
ALL-SIL CTRP2 5.8144 7.4623 5.5623 8.9919
JURL-MK1 CTRP2 5.8877 8.519 5.2002 10.2128
RS4;11 CTRP2 5.8938 8.776 5.0897 10.6422
MOLM-16 CTRP2; CTRP1 5.8945 7.2422 5.7337 8.3397
L-540 CTRP2 6.0127 7.0985 5.8988 7.1551
KMM-1 CTRP2 6.0527 12.6639 3.3577 19.6675
MOLT-13 CTRP2 6.0865 9.517 4.3431 7.5928
TALL-1 [Human adult T-ALL] CTRP2 6.1266 9.5118 4.9702 10.5655
KMS-12-BM CTRP2 6.1308 7.5412 5.8711 7.9648
SU-DHL-6 CTRP2 6.1538 7.6121 5.867 6.8707
SU-DHL-4 CTRP2; CTRP1 6.1616 7.2307 6.0279 6.4625
RCH-ACV CTRP2 6.1622 7.5167 5.9141 6.6655
SR CTRP2 6.2031 7.5037 5.9627 6.364
MOLM-6 CTRP2 6.2087 8.6991 5.437 8.453
SU-DHL-10 CTRP2 6.2781 8.3624 5.663 7.3623
L-363 CTRP2 6.3408 7.2996 6.1879 5.1142
NB4 CTRP2 6.3599 8.8811 4.8797 4.6396
OCI-Ly10 CTRP1 6.3991 16.8444 1.606 36.0653
KYO-1 CTRP2 6.4331 7.1124 6.3527 4.2273
MM1.S CTRP2 6.4402 8.5347 5.7394 6.6583
HPB-ALL CTRP2 6.445 9.2017 5.4208 7.9666
MOLP-2 CTRP2 6.4669 7.7188 6.1466 4.9347
Raji CTRP2 6.5564 6.9686 6.5275 3.2166
MHH-CALL-4 CTRP2 6.5678 9.1773 5.546 7.1699
MC116 CTRP2; CTRP1 6.5978 7.3162 6.4554 3.3672
Reh CTRP2 6.679 7.2998 6.5473 2.7876
HEL CTRP2 6.7821 8.5952 6.0277 4.6871
MHH-CALL-3 CTRP2 6.888 12.3843 4.2286 12.0067
Karpas-620 CTRP2 7.1383 11.4399 4.9094 8.6877
REC-1 CTRP2 7.2964 11.5386 4.9884 8.0612
ME1 CTRP2 7.8302 10.4078 5.9464 3.193
P3HR-1 CTRP2; CTRP1 7.9524 13.15 4.6949 8.1403
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 6.8606 10.8567 4.9688 8.9801
KYSE-140 CTRP2; CTRP1 4.1233 10.3391 2.5928 24.925
TE-10 CTRP2 5.184 7.9965 4.6859 14.1213
TE-9 CTRP2 5.2015 6.4009 5.164 12.3052
TE-4 CTRP2 5.3109 8.5318 4.6017 14.1004
KYSE-450 CTRP1 5.3676 7.0958 4.2849 5.7969
COLO 680N CTRP2 5.6405 8.3426 5.0245 11.5568
KYSE-180 CTRP2 5.8985 9.3757 4.815 11.7461
TE-1 CTRP2 5.9727 7.7968 5.6009 8.4013
KYSE-70 CTRP2 5.9856 8.3005 5.3974 9.1716
KYSE-410 CTRP2; CTRP1 7.8663 12.4633 4.9692 7.1518
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 5.3654 9.5305 4.2152 15.4907
KP-N-SI9s CTRP2 5.7053 6.8977 5.3103 4.0914
NB1 CTRP2 5.9441 7.389 5.7285 7.9909
CHP-126 CTRP2 6.5197 7.2295 6.406 3.7753
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 3.9193 6.5271 3.7571 21.3131
SNU-1079 CTRP2 4.1789 6.6095 4.0214 20.9371
HuCC-T1 CTRP2 5.3584 7.0589 5.1963 11.6986
HuH-28 CTRP2 5.634 8.2271 5.0671 11.4064
SNU-1196 CTRP2 5.9288 8.7021 5.1585 10.2762
SNU-308 CTRP2 6.7896 11.5567 4.5584 10.8403
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP2 4.2825 6.8782 4.0704 21.9469
MHH-ES-1 CTRP2 5.4026 6.5678 5.3548 10.996
SW1353 CTRP2 5.5665 6.1575 5.5641 11.2182
CAL-78 CTRP2 6.4732 9.6355 5.234 8.682
SJSA-1 CTRP2 6.5275 8.9326 5.6289 6.9143
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1954 CTRP2 4.8572 6.7938 4.7178 17.2281
CAMA-1 CTRP2 5.0315 7.5317 4.692 15.5559
HCC1395 CTRP2 5.2046 6.8493 5.083 12.58
MCF-7 CTRP2; CTRP1 5.3312 8.3732 4.7029 15.9446
CAL-51 CTRP2 5.3521 8.1739 4.7937 13.2388
HCC1806 CTRP2 5.4921 6.8559 5.3947 12.1717
HDQ-P1 CTRP2 5.5732 10.0202 4.1933 15.0605
ZR-75-1 CTRP2 5.6079 8.161 5.0675 11.4749
HCC1143 CTRP2 5.7292 9.055 4.7971 12.2366
CAL-148 CTRP2 5.7418 6.9323 5.6484 8.89
MDA-MB-231 CTRP2 6.0842 9.6929 4.8426 11.1907
HCC1937 CTRP2 6.1693 9.6501 4.9439 10.5746
KPL-1 CTRP2 7.0742 9.1283 6.0122 4.163
JIMT-1 CTRP2 7.4788 9.7987 5.9938 3.5319
HMC-1-8 CTRP2 7.7613 10.6289 5.7917 3.9242
CAL-120 CTRP2 7.8036 10.4575 5.9042 3.4021
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 3.9489 4.926 3.948 20.5577
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-466 CTRP2 4.0652 5.1412 4.0629 19.7849
Daoy CTRP2 5.2387 7.405 4.9594 12.9287
LN-18 CTRP2 5.2862 6.3703 5.2578 11.7074
SF295 CTRP2; CTRP1 5.4211 6.3469 5.4026 10.7716
LN-229 CTRP2; CTRP1 5.5131 8.1022 5.0053 12.1875
SNU-738 CTRP2 5.5812 7.0188 5.4506 10.0968
SNU-201 CTRP2 5.5879 8.4697 4.9153 12.9797
SNU-1105 CTRP2 5.7575 6.3478 5.7527 9.7573
GB-1 CTRP2 6.0567 8.4337 5.4094 8.9419
GaMG CTRP2; CTRP1 6.1179 9.5338 4.9513 10.6641
KALS-1 CTRP2 6.7276 10.8885 4.8385 9.797
SW1088 CTRP2 6.9681 9.8939 5.5411 6.3563
KNS-60 CTRP2 6.9886 8.3328 6.3388 2.9506
DBTRG-05MG CTRP2 7.0082 8.2551 6.3941 2.6785
ONS-76 CTRP2 7.0477 9.6327 5.7383 5.747
KNS-81 CTRP2 7.1294 8.6111 6.3153 2.7826
SNU-626 CTRP2 7.5888 9.1338 6.3932 1.7371
SNU-489 CTRP2 7.768 9.6812 6.2512 2.0612
NMC-G1 CTRP2 8.0157 9.8533 6.324 1.4886
CAS-1 CTRP2 8.0401 11.4258 5.6003 4.2914
U-87MG ATCC CTRP2 8.8255 11.6491 5.9826 2.1747
SF126 CTRP2 8.8633 13.3252 5.2412 4.6041
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-151 CTRP2; CTRP1 3.5513 6.5137 3.3648 24.0425
MFE-319 CTRP1 3.8216 7.5218 2.6889 26.327
RL95-2 CTRP2 4.1037 5.8521 4.0641 21.0354
HEC-1-B CTRP2 4.5343 7.6065 4.1278 19.3674
KLE CTRP2; CTRP1 4.5734 6.7038 4.4295 16.8772
HEC-6 CTRP2; CTRP1 5.0931 6.6949 4.9964 13.2365
JHUEM-2 CTRP2; CTRP1 5.192 7.54 4.8724 13.6006
HEC-251 CTRP2; CTRP1 5.2954 7.5343 4.9766 12.6987
HEC-59 CTRP2; CTRP1 5.8175 7.2171 5.6495 8.6566
HEC-50B CTRP2 6.3081 9.6974 5.0513 9.812
HEC-108 CTRP2; CTRP1 6.8189 12.033 4.3455 11.6641
EFE-184 CTRP2 6.9817 10.2605 5.3693 7.0541
HEC-265 CTRP2; CTRP1 7.2458 9.1049 6.1609 3.2243
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 12.6079 25.9107 1.7283 12.2121
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P CTRP2 5.7719 7.5793 5.4735 10.8803
BFTC-909 CTRP2 6.4174 9.9078 5.049 9.5769
OS-RC-2 CTRP2 6.766 9.0037 5.8107 6.0278
TUHR4TKB CTRP2 7.3873 9.4004 6.1221 3.1475
SNU-1272 CTRP2 7.6821 9.5949 6.2357 2.2377
VMRC-RCW CTRP2; CTRP1 8.0295 12.7349 4.9558 6.9436
KMRC-20 CTRP2 8.3501 12.3272 5.3782 4.7459
TUHR10TKB CTRP2 8.4199 9.9631 6.4891 0.602
RCC10RGB CTRP1 9.6661 11.1 6.6005 0.17
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW948 CTRP1 1.5219 5.6337 1.3372 70.3793
LS513 CTRP2; CTRP1 1.869 3.5601 1.8671 36.8948
CCK-81 CTRP2 2.9108 4.3509 2.8999 22.4627
SNU-C5 CTRP2; CTRP1 3.1498 4.822 3.1409 26.109
SW48 CTRP2; CTRP1 3.2674 6.5224 3.0493 25.8637
RCM-1 [Human ESC] CTRP1 3.6267 7.5345 3.1733 49.2694
SW480 CTRP1 3.6583 5.7034 3.6113 48.6442
GP2d CTRP1 3.8145 5.7294 3.4731 20.4346
SW620 CTRP2; CTRP1 3.9176 4.9115 3.9167 20.9599
LS180 CTRP2; CTRP1 3.9403 6.2175 3.8428 21.1386
SNU-81 CTRP1 4.0124 5.1254 4.0099 43.5363
C2BBe1 CTRP1 4.1269 5.9699 3.7027 16.7135
CW-2 CTRP2; CTRP1 4.1826 6.387 4.0746 19.5591
COLO 320 CTRP1 4.2424 12.0186 1.9663 45.5412
HT115 CTRP2; CTRP1 4.3034 7.6036 3.8871 19.865
COLO205 CTRP2; CTRP1 4.4637 5.0585 4.4637 17.112
KM12 CTRP2; CTRP1 4.556 5.697 4.5477 16.7257
HT-55 CTRP2; CTRP1 4.6532 7.4113 4.3294 17.1989
COLO 678 CTRP1 4.7201 7.9364 4.2227 36.4159
LoVo CTRP2; CTRP1 4.7796 7.0402 4.5764 15.9174
RKO CTRP2; CTRP1 4.8342 6.6857 4.7218 15.2291
HCT 116 CTRP2; CTRP1 4.848 5.9556 4.8356 14.7914
SNU-C4 CTRP1 4.8879 5.816 4.883 31.0488
SNU-C2A CTRP2; CTRP1 5.2372 8.2345 4.6479 16.2535
SNU-1040 CTRP1 5.3595 5.997 5.3578 24.2889
OUMS-23 CTRP2 5.526 6.7556 5.4537 10.2568
SNU-175 CTRP2; CTRP1 5.6486 7.509 5.377 10.387
LS123 CTRP2; CTRP1 5.8135 8.3238 5.226 10.5173
HT-29 CTRP2; CTRP1 5.9109 6.7319 5.8778 7.7716
NCI-H508 CTRP2; CTRP1 5.958 9.2223 4.9633 11.207
SK-CO-1 CTRP2; CTRP1 6.2144 8.6912 5.4463 8.4013
CL-11 CTRP2 6.2226 8.2139 5.6762 7.4472
SNU-407 CTRP2 6.4799 8.841 5.6291 7.0219
SW403 CTRP1 6.5023 9.904 3.7076 7.2459
COLO201 CTRP2 6.5401 8.9603 4.9761 3.8877
HCT 8 CTRP1 6.7466 8.1538 6.2335 8.8412
CL-34 CTRP1 6.8828 7.7327 6.5659 5.2301
MDST8 CTRP2; CTRP1 6.9673 9.6864 5.6681 6.0336
DLD-1 CTRP2; CTRP1 7.0283 9.3011 5.888 4.775
CL-40 CTRP1 7.0857 9.357 5.9321 10.0287
LS411N CTRP2; CTRP1 7.7341 9.8223 6.1619 2.6343
SNU-61 CTRP2; CTRP1 7.9903 11.8204 5.4026 5.363
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 3.4832 5.8494 3.4055 23.9336
JHH-6 CTRP1 4.284 4.7696 4.2711 11.162
SNU-886 CTRP2 5.0326 10.7488 3.3209 19.8374
SNU-398 CTRP2; CTRP1 5.0915 8.2824 4.4872 15.3479
SNU-878 CTRP2 5.231 7.4361 4.9406 13.0214
Hep 3B2.1-7 CTRP2 5.7347 9.1492 4.7592 14.243
SNU-449 CTRP1 6.2101 8.1075 4.3534 2.8857
Li-7 CTRP2 6.261 8.2927 5.6784 7.3421
Hep-G2 CTRP2; CTRP1 7.0354 9.3611 5.8881 4.9737
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 124 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3255 CTRP1 0.5944 4.1124 0.5389 80.4024
HCC2935 CTRP1 1.4159 5.5053 1.2446 71.4006
HCC827 CTRP2; CTRP1 1.5524 3.5889 1.5476 36.7524
NCI-H1568 CTRP1 1.9213 5.7565 1.4216 46.0552
NCI-H1963 CTRP1 2.3451 7.0421 1.9192 61.5233
HCC4006 CTRP1 2.415 4.4153 2.404 65.4779
PC-14 CTRP2 2.5169 3.5105 2.5168 30.1323
NCI-H1666 CTRP2; CTRP1 2.6078 5.6533 2.4976 29.8949
NCI-H23 CTRP1 2.7172 6.4947 2.0061 37.4683
NCI-H1105 CTRP1 2.8567 4.2684 2.8548 59.9279
NCI-H1836 CTRP1 3.1159 5.2133 3.0857 56.0025
COLO 668 CTRP1 3.1543 5.8604 2.7173 30.3246
NCI-H1876 CTRP1 3.3641 6.8381 3.0848 52.2331
NCI-H211 CTRP2 3.4217 5.6578 3.3642 24.2757
HCC1588 CTRP2 3.4472 4.5627 3.4463 23.9132
NCI-H2081 CTRP1 3.553 5.45 3.5237 50.0817
COR-L51 CTRP1 3.5707 8.0363 2.9466 49.8823
NCI-H727 CTRP2; CTRP1 3.5964 6.7572 3.3524 27.3424
SHP-77 CTRP2; CTRP1 3.6145 5.2739 3.5981 22.8463
NCI-H810 CTRP1 3.6876 4.73 3.6377 19.9543
SCLC-21H CTRP1 3.7199 5.7773 3.6684 47.8071
NCI-H1048 CTRP1 3.7344 4.9679 3.6372 19.6443
NCI-H2029 CTRP1 3.9006 5.2019 3.7531 17.6645
COR-L88 CTRP1 3.9032 5.1507 3.7715 17.5033
ChaGo-K-1 CTRP1 3.9046 6.4285 3.2735 21.507
LXF 289 CTRP2; CTRP1 3.9146 6.2998 3.7972 21.1873
NCI-H1437 CTRP1 3.9487 6.3579 3.3499 20.6398
VMRC-LCD CTRP1 3.9544 4.9883 3.872 16.3913
NCI-H2087 CTRP2 3.965 7.5386 3.5317 21.9849
NCI-H1435 CTRP2; CTRP1 3.9755 6.6888 3.782 21.0488
NCI-H841 CTRP1 3.9863 7.1647 3.6762 44.9031
KNS-62 CTRP1 4.053 5.1104 3.9467 15.17
NCI-H1373 CTRP2; CTRP1 4.1064 7.4001 3.7295 20.8375
NCI-H1944 CTRP1 4.1375 6.7085 3.3803 19.3379
DMS 273 CTRP1 4.1381 5.1085 4.0401 13.892
NCI-H1793 CTRP1 4.1704 6.3942 3.5581 17.6821
COLO 699 CTRP2; CTRP1 4.2126 6.49 4.0875 22.3471
DMS 79 CTRP2 4.2372 8.5865 3.4482 21.498
NCI-H522 CTRP1 4.3109 6.2078 3.784 15.0043
CAL-12T CTRP2; CTRP1 4.3251 6.4192 4.2226 18.5897
NCI-H1581 CTRP2 4.3582 6.0231 4.3144 17.966
NCI-H1694 CTRP1 4.3848 6.21 4.3209 38.6021
NCI-H358 CTRP2; CTRP1 4.3961 7.139 4.1236 18.5243
NCI-H82 CTRP1 4.4813 5.1874 4.3893 8.9544
NCI-H2106 CTRP2 4.5011 5.6063 4.4945 16.8838
HCC1833 CTRP2; CTRP1 4.5178 6.572 4.4018 17.3518
HARA [Human squamous cell lung carcinoma] CTRP2; CTRP1 4.5301 5.813 4.514 16.722
NCI-H1975 CTRP2; CTRP1 4.5414 5.981 4.5123 16.6908
NCI-H1915 CTRP1 4.5604 6.733 3.7771 13.7755
LOU-NH91 CTRP2 4.5637 7.471 4.2045 17.7249
NCI-H1930 CTRP1 4.5922 5.2986 4.4687 7.6322
NCI-H596 CTRP1 4.5928 5.224 4.5927 35.2312
NCI-H661 CTRP2; CTRP1 4.6603 7.6472 4.2504 17.2697
NCI-H196 CTRP2 4.6741 6.5541 4.5706 16.0613
NCI-H1155 CTRP2 4.718 6.0587 4.6907 15.5037
COR-L279 CTRP1 4.7734 6.1287 4.2708 8.3799
T3M-10 CTRP1 4.8361 8.3603 4.1855 35.7327
HCC44 CTRP2; CTRP1 4.8643 7.7023 4.4518 15.9213
NCI-H2122 CTRP2; CTRP1 4.8977 6.8747 4.748 14.9384
NCI-H1573 CTRP2; CTRP1 4.9257 8.9461 4.0251 17.39
NCI-H2073 CTRP1 4.962 6.1447 4.9405 30.1095
LC-1/sq-SF CTRP1 4.9644 9.6755 2.6714 20.7129
NCI-H650 CTRP2; CTRP1 4.9835 7.5916 4.6194 14.9462
NCI-H1781 CTRP1 5.0294 6.7178 4.927 29.7314
NCI-H2009 CTRP2; CTRP1 5.054 7.959 4.5616 16.0143
RERF-LC-KJ CTRP1 5.1202 7.5995 3.8393 10.7096
NCI-H1838 CTRP2 5.1872 6.5159 5.1317 12.4633
HCC78 CTRP2; CTRP1 5.2302 7.4754 4.9264 13.0771
NCI-H1734 CTRP2 5.2406 6.9302 5.1022 12.3998
NCI-H69 CTRP2 5.2407 7.4887 4.9332 13.0207
NCI-H292 CTRP2 5.2515 7.1543 5.0522 12.5481
NCI-H2141 CTRP1 5.3111 16.7307 0.699 41.9443
NCI-H2023 CTRP2; CTRP1 5.3643 7.4127 5.1021 12.2414
COR-L23 CTRP1 5.398 6.1915 5.3908 23.778
NCI-H2291 CTRP2 5.4164 6.4659 5.3844 10.8492
NCI-H526 CTRP2 5.4248 6.0826 5.4219 10.6941
MOR/CPR CTRP2 5.4861 6.1178 5.4834 10.2835
Lu-65 CTRP1 5.4887 9.3503 3.2601 14.1549
NCI-H2126 CTRP2; CTRP1 5.5038 7.5362 5.201 11.2508
HCC33 CTRP1 5.564 7.579 4.1909 5.9599
EPLC-272H CTRP2; CTRP1 5.5969 8.922 4.7246 12.8636
NCI-H1184 CTRP2 5.5975 7.4415 5.3357 10.4727
Calu-6 CTRP2; CTRP1 5.605 8.6648 4.8475 12.352
HCC15 CTRP2; CTRP1 5.6128 6.8226 5.5384 9.9041
NCI-H1755 CTRP2; CTRP1 5.6624 7.8278 5.2728 10.744
RERF-LC-Ad1 CTRP2 5.6738 6.0188 5.6737 9.0192
NCI-H1355 CTRP2; CTRP1 5.7059 10.5429 4.0728 15.2255
SW1271 CTRP2 5.7822 7.9801 5.3253 9.9947
Lu-99 CTRP2; CTRP1 5.8013 7.7492 5.4392 9.5002
EBC-1 CTRP2; CTRP1 5.819 8.0519 5.3338 9.8624
LCLC-103H CTRP2; CTRP1 5.8655 8.9826 4.9663 11.2121
Calu-3 CTRP2; CTRP1 5.92 8.9769 5.0229 10.8472
RERF-LC-A1 CTRP2 5.9497 8.839 5.1163 10.3947
NCI-H441 CTRP2; CTRP1 5.9644 8.4005 5.3469 9.6445
SK-LU-1 CTRP2; CTRP1 6.0789 7.671 5.7768 7.6498
SW1573 CTRP2 6.1965 9.5689 5.009 10.2425
NCI-H1650 CTRP2 6.2061 10.0973 4.761 11.247
DV-90 CTRP1 6.3398 9.5097 3.7889 7.0372
LCLC-97TM1 CTRP2; CTRP1 6.3863 12.4211 3.7762 14.882
NCI-H889 CTRP2 6.4708 8.4685 5.8005 6.3344
Sq-1 CTRP2; CTRP1 6.5508 8.9227 5.6758 6.8845
NCI-H2286 CTRP2; CTRP1 6.5702 7.8657 6.1829 4.5281
NCI-H460 CTRP2; CTRP1 6.5891 9.4507 5.452 7.73
NCI-H2030 CTRP2; CTRP1 6.6083 10.5529 4.9235 9.8953
NCI-H2172 CTRP2; CTRP1 6.6461 10.8302 4.819 10.2516
HCC366 CTRP2 6.6581 9.5085 5.4641 7.3166
NCI-H2405 CTRP2; CTRP1 6.8121 9.3517 5.6781 7.0147
NCI-H1299 CTRP2; CTRP1 6.9605 9.7163 5.6235 6.0237
NCI-H1792 CTRP2; CTRP1 7.0462 11.8442 4.6313 10.0279
HCC2108 CTRP2; CTRP1 7.053 9.5988 5.784 5.3777
NCI-H2228 CTRP2 7.1106 9.8282 5.6922 5.4439
NCI-H446 CTRP2 7.3486 11.0359 5.2806 6.7403
HCC2279 CTRP2 7.3813 11.6242 5.0133 7.8025
NCI-H520 CTRP2 7.4118 11.4531 5.1226 7.2899
HCC95 CTRP2 7.4509 10.7557 5.4997 5.6405
HCC1359 CTRP1 7.492 9.0988 6.3734 4.5988
NCI-H226 CTRP2 7.6121 9.7508 6.1129 2.8343
NCI-H2342 CTRP1 7.7613 14.4264 3.9429 22.0172
A-549 CTRP2; CTRP1 7.7913 11.3913 5.4409 5.3221
HCC1195 CTRP2; CTRP1 7.7966 12.1116 5.1179 6.8458
BEN CTRP2; CTRP1 7.9028 9.8986 6.235 2.2493
NCI-H2110 CTRP1 8.0227 25.558 -1.4003 36.5693
HCC1171 CTRP2 8.3013 13.5282 4.7639 7.3016
SBC-5 CTRP2 8.3281 9.9194 6.463 0.7389
⏷ Show the Full List of 124 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 CTRP2; CTRP1 2.9948 8.8988 2.0137 30.3786
COV434 CTRP1 3.2952 7.3128 2.8795 52.7963
JHOS-4 CTRP1 3.5939 6.6314 2.866 26.4457
RMG-I CTRP2; CTRP1 3.6053 6.4577 3.4354 23.6249
RMUG-S CTRP1 4.1288 8.9022 3.2204 44.5863
SNU-119 CTRP2 4.4735 7.3974 4.1299 18.2685
OVK18 CTRP2; CTRP1 4.6556 7.9923 4.1329 17.9236
A2780 CTRP2; CTRP1 4.7529 7.5056 4.4075 16.6156
Kuramochi CTRP2 4.904 9.3257 3.8386 19.4357
COV644 CTRP1 4.914 7.947 4.4272 33.8469
TYK-nu CTRP2; CTRP1 5.0887 6.1905 5.0694 13.2092
COV362 CTRP1 5.2464 7.2367 5.0295 27.4924
OAW28 CTRP2 5.2584 8.575 4.5287 14.5278
OVSAHO CTRP2 5.3931 8.046 4.8885 14.6873
SNU-840 CTRP2; CTRP1 5.3959 10.4182 3.8505 17.0602
COV318 CTRP1 5.4796 9.0315 3.4114 12.963
ONCO-DG-1 CTRP2 5.5713 9.0265 4.6515 14.1496
SNU-8 CTRP2 5.5714 9.0548 4.6388 13.2722
ES2 CTRP2 5.6536 7.5707 5.3497 11.8101
OVTOKO CTRP2 5.6596 8.1162 5.1403 12.7215
OVKATE CTRP1 5.6776 9.7664 4.4329 28.8161
FU-OV-1 CTRP2 5.8013 10.5308 4.1696 14.6086
DOV13 CTRP2 5.946 7.1576 5.8081 8.8514
OVCAR-8 CTRP2; CTRP1 5.9879 9.737 4.7484 12.0112
IGROV-1 CTRP2; CTRP1 6.07 10.9444 4.2409 13.8954
OVMANA CTRP1 6.1204 7.48 4.5767 1.4619
SK-OV-3 CTRP2; CTRP1 6.2946 9.3499 5.2077 9.1944
Caov-3 CTRP2; CTRP1 6.3127 9.0193 5.4038 8.5567
EFO-27 CTRP1 6.4922 10.5178 4.8371 21.7312
EFO-21 CTRP1 6.5425 10.3037 3.5458 8.4087
OVISE CTRP2 6.6747 8.3535 6.0488 5.5666
MCAS CTRP2 6.7643 8.7916 5.9144 5.2005
HEY A8 CTRP2; CTRP1 7.0687 9.8775 5.6332 5.7722
OV7 CTRP1 7.8111 12.2945 5.0385 14.6788
OV-90 CTRP1 7.9551 13.182 4.7083 16.5458
OAW42 CTRP1 8.3816 9.4618 6.7017 0.461
JHOM-1 CTRP1 8.6756 14.4179 4.6241 14.7325
JHOC-5 CTRP2; CTRP1 10.1079 17.5109 4.1028 7.5303
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Capan-2 CTRP1 3.4651 5.7082 3.1072 25.4729
Panc 10.05 CTRP1 4.0246 5.3184 3.85 16.1131
Panc 03.27 CTRP1 4.3903 6.548 3.7036 15.2736
HPAC CTRP1 4.8686 5.9352 4.4536 6.2977
SNU-213 CTRP2 5.3439 6.9351 5.2137 11.6802
KP-3 CTRP2; CTRP1 5.4872 8.031 4.994 12.0906
HuP-T4 CTRP2; CTRP1 5.6107 8.7308 4.824 12.4307
QGP-1 CTRP2; CTRP1 5.6761 7.9792 5.2143 12.3371
PK-59 CTRP2 6.3986 8.409 5.7591 6.6765
YAPC CTRP2 6.4648 7.742 6.1341 4.9899
Panc 05.04 CTRP2 6.7705 10.0289 5.3044 7.7519
BxPC-3 CTRP2 6.8032 10.4409 5.1272 9.0218
SU.86.86 CTRP2 7.1731 9.2914 6.0109 3.9846
KP-4 CTRP2 7.373 9.5643 6.0305 3.5532
SNU-410 CTRP2 7.4206 10.0859 5.8085 4.4004
SUIT-2 CTRP2; CTRP1 7.4535 9.6123 6.0667 3.27
PaTu 8902 CTRP2; CTRP1 7.7827 15.1303 3.5833 12.901
HPAF-II CTRP2 7.8532 11.0279 5.6627 4.9653
L3.3 CTRP2 8.0735 11.3375 5.6655 3.9805
TCC-Pan2 CTRP2 8.1397 11.4236 5.6688 3.8744
CFPAC-1 CTRP2; CTRP1 8.4336 12.0241 5.5771 4.4242
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2; CTRP1 4.555 6.2135 4.4996 16.6899
MSTO-211H CTRP1 4.5695 5.886 4.1901 10.1223
ACC-MESO-1 CTRP2 5.3773 8.7539 4.5749 14.0297
NCI-H2452 CTRP2 6.1351 9.923 4.7795 11.3326
NCI-H2052 CTRP2; CTRP1 8.98 13.1895 5.3774 3.9373
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 4.3609 7.7689 3.0858 20.5216
22Rv1 CTRP2 5.4556 7.4284 5.1866 13.1761
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 4.467 6.2276 4.4035 17.3066
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-5 CTRP2; CTRP1 4.2462 5.3602 4.2423 18.7776
G-361 CTRP2; CTRP1 4.266 5.8496 4.2352 18.5381
COLO 741 CTRP1 4.3367 5.5728 4.0887 12.2814
Hs 852.T CTRP2; CTRP1 4.811 7.8925 4.3259 16.5496
A-375 CTRP2; CTRP1 5.2093 6.2218 5.1929 12.3945
Mel Ho CTRP2 5.3217 7.2628 5.0956 12.1779
Hs 944.T CTRP2; CTRP1 5.803 7.7873 5.4258 9.547
SK-MEL-1 CTRP2; CTRP1 6.0943 7.2065 5.9625 6.9032
MDA-MB-435S CTRP2 6.164 7.7263 5.8307 6.9844
WM1799 CTRP2 6.2692 7.4842 6.0405 5.8804
WM793 CTRP2 6.4061 7.2235 6.2859 4.5558
Mel JuSo CTRP2 6.4099 7.6859 6.1029 5.2567
IPC-298 CTRP2 6.7552 7.4608 6.5541 2.5626
SK-MEL-31 CTRP2 6.7897 7.4479 6.5943 2.3143
SK-MEL-30 CTRP2 6.8295 7.6179 6.5517 2.3942
RPMI-7951 CTRP2 7.4535 10.298 5.7285 4.679
Hs 936.T CTRP2; CTRP1 7.5881 8.8649 6.5191 1.2453
SK-MEL-28 CTRP2; CTRP1 8.3193 8.9696 6.8516 0.0277
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 4.0303 7.7842 2.7664 24.6235
Rh41 CTRP2 4.4738 6.8074 4.2966 17.6616
RKN CTRP2; CTRP1 4.6597 5.9146 4.6429 16.0625
HT-1080 CTRP1 5.1422 6.8275 5.0255 28.2315
Rh18 CTRP2 6.8601 10.9547 4.9194 9.1887
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 CTRP2; CTRP1 4.4008 6.0423 4.3574 17.6797
AGS CTRP2; CTRP1 4.5499 5.6168 4.5444 16.7569
KE-39 CTRP2 4.7175 6.9333 4.5307 16.068
GSS CTRP2 4.7468 6.4178 4.6741 16.5551
NCI-N87 CTRP2 4.861 7.1923 4.6151 15.3248
SH-10-TC CTRP1 4.904 5.6201 4.6407 4.4629
NUGC-3 CTRP2 4.9656 6.6805 4.861 14.1168
Fu97 CTRP2; CTRP1 4.9879 9.0888 4.0281 17.2117
SNU-620 CTRP2 5.014 7.3028 4.7481 14.3773
MKN74 CTRP2; CTRP1 5.0523 8.5871 4.3085 15.9442
SNU-719 CTRP2 5.3685 7.5882 5.0365 12.2617
SNU-5 CTRP2 5.4031 6.0638 5.4004 10.8385
MKN7 CTRP1 5.4169 8.1827 3.7844 10.0359
23132/87 CTRP2 5.491 6.4361 5.4672 10.3224
ECC10 CTRP2 5.771 7.5872 5.4696 9.4683
SNU-668 CTRP2 6.0333 8.5581 5.3291 9.3247
GSU CTRP2 7.1847 8.8903 6.22 3.0838
MKN1 CTRP2 7.2424 10.113 5.6564 5.3516
ECC12 CTRP2 7.3508 9.7569 5.9183 4.0599
OCUM-1 CTRP2 7.5483 18.2223 1.8544 19.4931
MKN45 CTRP2 8.3748 9.2262 6.7479 0.0896
SNU-1077 CTRP2 5.5224 8.9715 4.6268 14.3896
SNG-M CTRP2; CTRP1 6.7773 8.6741 5.9843 4.8795
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT CTRP2 5.1237 7.9054 4.6564 14.4037
8305C CTRP2 5.1499 7.6476 4.7796 13.8614
CGTH-W-1 CTRP2 5.4339 8.8639 4.5846 13.8429
B-CPAP CTRP2 5.5548 8.3307 4.9407 12.1154
8505C CTRP2 5.6323 7.9269 5.1893 10.9335
ML-1 [Human leukemia] CTRP2 7.0133 8.1554 6.4483 2.4402
BHT-101 CTRP2 7.195 9.1052 6.1211 3.4815
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 2.8727 5.2554 2.8264 27.9084
SCC-9 CTRP1 3.9147 6.6176 3.7372 45.4821
SNU-1214 CTRP2 4.0012 5.9024 3.9501 20.3785
HSC-2 CTRP1 4.0404 5.1382 3.9247 15.4231
BHY CTRP2 4.533 7.9879 3.992 18.6085
SNU-1076 CTRP2 4.673 6.9761 4.4709 16.4204
Detroit 562 CTRP2 4.7195 6.3013 4.663 17.9524
SNU-46 CTRP2 4.8225 6.4281 4.7538 14.9474
SNU-899 CTRP2 5.1864 6.2746 5.1626 12.3592
HSC-3 CTRP2 5.2645 8.2066 4.688 15.9883
SNU-1041 CTRP2 5.4159 8.4651 4.7392 15.2856
SCC-25 CTRP2 5.5864 9.4155 4.4888 13.8376
HSC-4 CTRP2 5.5902 9.0315 4.6683 13.1061
YD-8 CTRP2 6.6398 9.7089 5.3483 7.8413
SNU-1066 CTRP2 6.9569 9.8158 5.5707 7.1988
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 CTRP2; CTRP1 3.6659 6.6362 3.4571 23.1708
5637 CTRP2; CTRP1 4.2571 6.3086 4.1652 18.8086
KMBC-2 CTRP1 4.6856 7.4425 3.5433 15.1967
JMSU-1 CTRP2 5.1456 7.2787 4.8988 13.4289
KU-19-19 CTRP2 5.4461 6.0161 5.4449 12.1408
TCCSUP CTRP2 5.6535 8.9822 4.7545 12.5993
CAL-29 CTRP2 5.7818 8.4554 5.1208 10.8034
639V CTRP2 6.1599 7.7583 5.813 7.5618
RT-4 CTRP2; CTRP1 6.2177 8.1045 5.7208 7.2802
VM-CUB-1 CTRP2 6.3265 9.8355 5.0008 10.6806
UM-UC-3 CTRP2; CTRP1 6.3335 8.7845 5.5173 7.8247
SW1710 CTRP2 6.7787 8.6751 5.9851 4.8733
253J CTRP2 6.9958 8.8869 6.0678 4.0795
RT-112 CTRP2 7.3399 10.2816 5.6492 5.2074
253J-BV CTRP2 7.9617 10.7766 5.8586 3.3612
BFTC-905 CTRP2 8.4852 10.1279 6.4531 0.6609
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 8.5167 9.3846 6.7441 0.0594

References

1 Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304.