Details of the Drug

General Information of Drug (ID: DMFVL5J)

Drug Name
AZD-4877
Synonyms Anticancer therapeutic (solid tumors), AstraZeneca
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 503.7
Logarithm of the Partition Coefficient (xlogp) 4.5
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C28H33N5O2S
IUPAC Name
N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide
Canonical SMILES
CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C(=NS3)C)C(=O)N2CC4=CC=CC=C4)C(C)C
InChI
InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3
InChIKey
SMFXSYMLJDHGIE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10368812
CAS Number
1176760-49-8
UNII
19ORU63E06
DrugBank ID
DB11671
TTD ID
D02AAO

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [3]
Somatostatin receptor type 1 (SSTR1) OTFAGWO7 SSR1_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute myeloid leukaemia
ICD Disease Classification 2A60
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Kinesin-like protein KIF11 (KIF11) DTT KIF11 5.72E-26 -1.17 -1.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -7.1552 -4.5386 -7.4213 32.548
MHH-ES-1 GDSC1 -7.8209 -6.5994 -7.8209 59.5111
ES7 GDSC1 -7.7216 -6.1746 -7.7401 38.1239
HuO9 GDSC1 -7.6852 -4.4585 -8.0228 39.1898
EW-1 GDSC1 -7.6807 -6.2461 -7.6938 37.5821
ES1 GDSC1 -7.6199 -6.2933 -7.6291 36.8002
ES8 GDSC1 -7.5748 -6.5374 -7.5769 36.1933
A-673 GDSC1 -7.4378 -6.5995 -7.4384 34.4713
NY GDSC1 -7.1773 -5.6801 -7.2114 31.4244
CAL-78 GDSC1 -7.1194 -3.4102 -7.7716 34.1871
EW-18 GDSC1 -7.0832 -4.4381 -7.3726 31.8087
SaOS-2 GDSC1 -6.9896 -5.115 -7.0965 29.5407
SJSA-1 GDSC1 -6.6032 -2.9834 -7.4005 29.1072
ES5 GDSC1 -6.5315 -3.9172 -6.9504 25.902
U2OS GDSC1 -6.1672 -3.5449 -6.7097 22.2944
EW-3 GDSC1 -6.1157 -3.317 -6.7521 22.3188
G-292 clone A141B1 GDSC1 -5.9327 -2.1867 -7.0795 23.6013
EW-22 GDSC1 -5.6458 -2.2539 -6.769 20.136
CAL-72 GDSC1 -5.5016 -1.8327 -6.8356 19.9435
ES4 GDSC1 -5.4919 -1.8994 -6.794 19.6108
HOS GDSC1 -5.3624 -4.6463 -5.4343 8.9997
NOS-1 [Human HNSCC] GDSC1 -5.0615 -1.0395 -6.8274 18.012
MG-63 GDSC1 -5.0314 -3.5209 -5.5736 8.4276
SK-ES-1 GDSC1 -4.9602 -3.667 -5.4358 7.055
EW-7 GDSC1 -4.8966 -3.399 -5.5091 7.3633
TC-71 GDSC1 -4.8366 -3.562 -5.3745 6.068
SK-PN-DW GDSC1 -4.8169 -3.1916 -5.5414 7.3015
HuO-3N1 GDSC1 -4.7769 -1.1378 -6.5327 14.7876
CHSA0108 GDSC1 -4.6801 -0.2248 -6.908 17.0818
CHSA0011 GDSC1 -4.5859 -0.8469 -6.519 13.9801
CADO-ES1 GDSC1 -4.5234 6.1563 -9.9685 30.7397
H-EMC-SS GDSC1 -3.2301 9.223 -10.4635 28.3721
CHSA8926 GDSC1 -1.4411 10.0865 -9.5696 21.0092
ES6 GDSC1 -0.461 4.2744 -6.3212 3.4647
EW-13 GDSC1 -0.2112 4.7331 -6.3895 3.5073
EW-24 GDSC1 -0.0954 1.7392 -5.2608 0.0429
EW-11 GDSC1 0.3539 3.5255 -5.7028 0.5413
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 155 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -5.4201 -4.2566 -5.6329 10.7088
MOLP-8 GDSC1 -9.5435 -4.8446 -9.9437 57.8589
EoL-1 GDSC1 -9.1211 -7.937 -9.1214 55.5016
CRO-AP2 GDSC1 -8.6717 -6.8599 -8.6846 49.8933
MV4-11 GDSC1 -8.4559 -6.6757 -8.4711 47.2343
Reh GDSC1 -8.1867 -6.7846 -8.192 43.8553
JVM-3 GDSC1 -8.0616 -3.6662 -8.6898 44.1292
MOLT-16 GDSC1 -8.0183 -7.1501 -8.0184 41.7244
697 GDSC1 -7.9707 -7.0858 -7.971 41.1309
BV-173 GDSC1 -7.9103 -6.6717 -7.9139 40.3952
NKM-1 GDSC1 -7.8282 -6.2773 -7.8443 39.4395
MOLT-13 GDSC1 -7.807 -6.5969 -7.8108 39.1054
Loucy GDSC1 -7.7071 -6.5606 -7.7102 37.8528
Sc-1 GDSC1 -7.6444 -6.603 -7.6462 37.0618
OCI-AML-2 GDSC1 -7.6186 -6.8669 -7.6187 36.7288
P30/OHK GDSC1 -7.6173 -6.0793 -7.638 36.8354
MHH-PREB-1 GDSC1 -7.543 -6.5136 -7.545 35.7952
BC-1 GDSC1 -7.4782 -6.3421 -7.4828 35.0007
Jurkat GDSC1 -7.4315 -5.1041 -7.5786 35.2477
RPMI-8226 GDSC1 -7.4298 -6.2972 -7.4348 34.399
OCI-AML-3 GDSC1 -7.4222 -6.7447 -7.4222 34.2728
Mono-Mac-6 GDSC1 -7.4209 -5.6492 -7.4731 34.5732
KE-37 GDSC1 -7.4207 -6.395 -7.4234 34.2709
MOLM-13 GDSC1 -7.4071 -6.0772 -7.4203 34.1653
SU-DHL-5 GDSC1 -7.3995 -6.7342 -7.3996 33.9899
P31/FUJ GDSC1 -7.3192 -6.422 -7.3205 32.9935
CTV-1 GDSC1 -7.3079 -6.233 -7.3125 32.8729
MLMA GDSC1 -7.2987 -6.1543 -7.3055 32.7709
JVM-2 GDSC1 -7.2945 -5.3721 -7.3786 33.1916
Karpas-620 GDSC1 -7.2894 -3.9153 -7.768 35.2708
RPMI-6666 GDSC1 -7.2389 -4.6331 -7.4856 33.4534
Raji GDSC1 -7.1991 -4.5063 -7.4785 33.1556
CCRF-CEM GDSC1 -7.1466 -5.5523 -7.1936 31.1219
L-363 GDSC1 -7.1278 -6.0314 -7.1351 30.6388
BE-13 GDSC1 -7.1201 -5.4734 -7.1758 30.8455
BALL-1 GDSC1 -7.1154 -6.1068 -7.1199 30.4662
KMS-11 GDSC1 -7.1148 -5.0758 -7.2405 31.2138
CML-T1 GDSC1 -7.0911 -4.7474 -7.2933 31.387
A3/Kawakami GDSC1 -7.0873 -4.0681 -7.4966 32.5438
CMK GDSC1 -7.0769 -6.2006 -7.0789 29.9691
TK [Human B-cell lymphoma] GDSC1 -7.0627 -4.3657 -7.3726 31.6807
DB GDSC1 -7.0285 -4.7796 -7.2165 30.5293
CA46 GDSC1 -6.9866 -2.3781 -8.0572 34.6826
OCI-Ly7 GDSC1 -6.9834 -5.7304 -6.9834 78.4603
DEL GDSC1 -6.9494 -5.8596 -6.9595 28.4263
MC116 GDSC1 -6.9352 -5.5739 -6.9669 28.3855
RS4;11 GDSC1 -6.9339 -4.7382 -7.1242 29.3752
HDLM-2 GDSC1 -6.9156 -4.7644 -7.0973 29.0947
Ramos.2G6.4C10 GDSC1 -6.89 -5.2355 -6.966 28.103
HH [Human lymphoma] GDSC1 -6.8842 -3.1524 -7.6246 31.9873
ST486 GDSC1 -6.884 -4.1841 -7.237 29.7724
HC-1 GDSC1 -6.8502 -5.1544 -6.9378 27.681
GA-10 GDSC1 -6.8345 -3.0334 -7.6212 31.6732
A4/Fukuda GDSC1 -6.8233 -4.7062 -7.012 27.9954
RPMI-8402 GDSC1 -6.8066 -4.6405 -7.0118 27.8952
NB4 GDSC1 -6.7871 -4.7351 -6.9648 27.4758
AMO1 GDSC1 -6.7757 -5.2164 -6.8462 26.6412
EM-2 GDSC1 -6.6779 -4.3911 -6.9457 26.7098
P32/ISH GDSC1 -6.6367 -4.949 -6.7484 25.1737
RCH-ACV GDSC1 -6.624 -4.8647 -6.7541 25.1362
SR GDSC1 -6.5944 -1.9486 -7.8477 31.4564
MOLM-16 GDSC1 -6.5737 -4.6496 -6.7551 24.8486
ML-2 GDSC1 -6.5442 -4.8129 -6.6798 24.1778
OCI-AML-5 GDSC1 -6.361 -4.5899 -6.54 22.1847
Karpas-45 GDSC1 -6.293 -4.094 -6.6292 22.414
MOLT-4 GDSC1 -6.2877 -4.3095 -6.5481 21.8269
SU-DHL-6 GDSC1 -6.2771 -3.7708 -6.7345 23.0502
JeKo-1 GDSC1 -6.1607 -5.1892 -6.1907 18.6946
WSU-NHL GDSC1 -5.9762 -4.1846 -6.2553 18.0883
KCL-22 GDSC1 -5.934 -4.6387 -6.0601 16.5
Hs 445 GDSC1 -5.8824 4.9623 -10.5368 36.8551
Namalwa GDSC1 -5.8505 -4.5089 -6.008 15.6746
BL-41 GDSC1 -5.7984 5.7451 -10.8519 37.1905
SU-DHL-16 GDSC1 -5.6587 -4.1891 -5.9133 13.9707
KOPN-8 GDSC1 -5.657 -4.6114 -5.7658 12.9267
TUR GDSC1 -5.6423 -4.8513 -5.689 12.3252
CESS GDSC1 -5.641 -4.2284 -5.8794 13.6349
K-562 GDSC1 -5.6172 -4.3709 -5.8013 12.9538
U-698-M GDSC1 -5.6135 -4.6178 -5.7165 12.3444
Karpas-231 GDSC1 -5.5707 -4.439 -5.7273 12.1818
HAL-01 GDSC1 -5.5706 -4.4575 -5.7208 12.1357
MEG-01 GDSC1 -5.549 -1.1717 -7.2025 22.5926
LC4-1 GDSC1 -5.5289 -3.2735 -6.1742 15.2508
SUP-HD1 GDSC1 -5.5136 -3.2572 -6.1665 15.1219
IM-9 GDSC1 -5.5131 -4.3666 -5.6907 11.6127
ALL-SIL GDSC1 -5.4849 -4.3325 -5.673 11.3373
KMOE-2 GDSC1 -5.4656 -3.8999 -5.8286 12.3695
ATN-1 GDSC1 -5.46 -4.6959 -5.5271 10.1848
QIMR-WIL GDSC1 -5.4587 -3.2421 -6.1192 14.5117
KY821 GDSC1 -5.4392 -4.3291 -5.6253 10.7544
ARH-77 GDSC1 -5.3944 -3.9339 -5.7405 11.3661
KM-H2 GDSC1 -5.3744 -3.7413 -5.8056 11.7551
GR-ST GDSC1 -5.374 -3.0836 -6.1111 14.0638
PL-21 GDSC1 -5.369 -3.5793 -5.8739 12.2437
Karpas-1106P GDSC1 -5.3384 -1.4411 -6.8765 19.5096
DG-75 GDSC1 -5.3053 -2.7371 -6.2118 14.5223
JSC-1 GDSC1 -5.3045 4.9014 -10.0008 33.4811
P12-Ichikawa GDSC1 -5.3037 -4.4854 -5.4223 8.5912
RPMI-8866 GDSC1 -5.2665 -4.0695 -5.5498 9.3245
Jiyoye GDSC1 -5.2664 0.0516 -7.5509 23.4727
DND-41 GDSC1 -5.2169 -2.1082 -6.437 15.8372
NOMO-1 GDSC1 -5.1558 -2.3131 -6.2803 14.4042
JJN-3 GDSC1 -5.1324 -4.2065 -5.3521 7.2005
GDM-1 GDSC1 -5.1265 -2.9419 -5.9446 11.7066
JURL-MK1 GDSC1 -5.102 -3.5804 -5.6119 9.0306
OCI-M1 GDSC1 -5.0872 -3.9018 -5.445 7.6852
HT GDSC1 -5.0869 -0.9752 -6.8818 18.4912
NCI-H929 GDSC1 -5.0529 -1.1009 -6.7893 17.7111
Kasumi-1 GDSC1 -4.9811 -3.644 -5.4664 7.3816
Karpas-299 GDSC1 -4.9308 2.348 -8.4054 26.4866
HL-60 GDSC1 -4.9074 -3.8456 -5.2993 5.7708
OCI-Ly19 GDSC1 -4.9058 -3.0177 -5.7064 8.9457
H9 GDSC1 -4.864 -1.2464 -6.5526 15.2668
KG-1 GDSC1 -4.837 -3.1991 -5.5553 7.4888
EJM GDSC1 -4.7925 -3.0685 -5.5816 7.5236
SUP-M2 GDSC1 -4.7272 -2.0462 -6.0367 10.8451
U266B1 GDSC1 -4.6949 -3.0278 -5.5188 6.6648
THP-1 GDSC1 -4.685 -2.3511 -5.8489 9.225
MHH-CALL-2 GDSC1 -4.6687 -2.7442 -5.6388 7.5152
Daudi GDSC1 -4.6619 -2.8994 -5.5555 6.8349
CTB-1 GDSC1 -4.6452 -1.8803 -6.0512 10.658
NU-DUL-1 GDSC1 -4.6431 -3.0071 -5.4862 6.2211
Ku812 GDSC1 -4.6127 0.5301 -7.2295 18.9429
OPM-2 GDSC1 -4.6066 -2.5015 -5.709 7.8464
L-428 GDSC1 -4.6055 -2.7027 -5.6075 7.0443
SU-DHL-8 GDSC1 -4.5999 -2.7307 -5.589 6.8792
Farage GDSC1 -4.5986 9.9468 -11.9259 35.457
HEL GDSC1 -4.5755 -1.6249 -6.1216 10.9524
SUP-B8 GDSC1 -4.5419 -2.2262 -5.7941 8.2892
Karpas-422 GDSC1 -4.4682 1.406 -7.5486 20.3503
SU-DHL-10 GDSC1 -4.466 1.3667 -7.5271 20.2169
L-540 GDSC1 -4.4626 -2.7121 -5.4895 5.6343
SU-DHL-4 GDSC1 -4.4319 -2.2735 -5.6836 7.054
NALM-6 GDSC1 -4.3445 5.6092 -9.548 28.8439
WSU-DLCL2 GDSC1 -4.2407 0.8712 -7.0988 16.7762
ALL-PO GDSC1 -4.1394 -0.5466 -6.3155 10.9545
MN-60 GDSC1 -3.9402 1.1549 -7.0065 15.1721
VL51 GDSC1 -3.8482 -0.4444 -6.1513 8.8465
SKM-1 GDSC1 -3.8415 3.5462 -8.1172 21.2869
SUP-T1 GDSC1 -3.7783 1.8056 -7.2057 15.9363
EB2 GDSC1 -1.2573 7.3041 -8.1165 14.3913
LP-1 GDSC1 -0.5428 2.6757 -5.7385 1.0507
LAMA-84 GDSC1 -0.4811 2.5425 -5.6664 0.7923
ME1 GDSC1 -0.4727 3.0126 -5.8348 1.3411
EHEB GDSC1 -0.4677 2.823 -5.7628 1.0861
SK-MM-2 GDSC1 -0.2667 3.6785 -6.0002 1.8209
Granta-519 GDSC1 -0.1132 2.4 -5.4837 0.261
RC-K8 GDSC1 -0.0009 2.514 -5.4833 0.2377
YT GDSC1 0.0727 1.9868 -5.286 0.0464
ROS-50 GDSC1 0.1072 2.9596 -5.5964 0.4002
L-1236 GDSC1 0.1638 4.0406 -5.9591 1.3573
WIL2 NS GDSC1 0.1956 1.9462 -5.2335 0.0219
RL GDSC1 0.4241 10.9045 -8.7415 13.8769
VAL GDSC1 0.496 3.1704 -5.5327 0.2146
PF-382 GDSC1 0.7874 3.1585 -5.4318 0.0847
⏷ Show the Full List of 155 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -7.0939 -5.403 -7.158 30.5707
OACP4 C GDSC1 -5.727 -3.4437 -6.2969 17.1103
ESO-26 GDSC1 -5.6069 -2.5051 -6.6117 18.8387
KYSE-220 GDSC1 -5.2969 -2.2097 -6.4609 16.3552
SK-GT-4 GDSC1 -4.9894 0.2741 -7.4196 21.5655
ESO-51 GDSC1 -4.9312 -1.1079 -6.6797 16.4491
KYSE-50 GDSC1 -4.7234 -1.2029 -6.4551 14.0143
FLO-1 GDSC1 -4.4784 0.2424 -6.9755 16.7984
OACM5.1 C GDSC1 -3.9941 2.286 -7.6095 19.0613
TE-12 GDSC1 -3.1126 1.6541 -6.6556 10.4037
KYAE-1 GDSC1 -0.4317 5.431 -6.7883 5.84
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -1.0316 7.5747 -5.1026 22.5001
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 -9.8082 -1.7702 -10.3665 78.4458
NB69 GDSC1 -8.7819 -6.5701 -8.7826 91.9145
GI-ME-N GDSC1 -8.3523 -4.4451 -8.7543 46.6848
NB1 GDSC1 -7.9482 -2.1928 -9.137 44.1357
GOTO GDSC1 -7.9468 -5.8154 -8.0115 41.15
IMR-5 GDSC1 -7.5029 -5.2781 -7.6205 35.962
SK-N-MC-IXC GDSC1 -7.4053 -6.6948 -7.4054 34.0625
Kelly GDSC1 -7.0945 -5.1323 -7.2068 30.8794
SK-N-AS GDSC1 -7.0602 -4.4236 -7.0719 76.3866
SJNB-5 GDSC1 -5.7818 -4.7239 -5.8708 14.3492
SK-N-BE(2)-M17 GDSC1 -5.6907 -3.8801 -6.0713 15.2776
SJNB-10 GDSC1 -5.5932 -4.507 -5.7288 12.3162
SK-N-DZ GDSC1 -5.4402 -3.3809 -6.0363 13.8012
SK-N-SH GDSC1 -5.3322 -3.9995 -5.6479 10.375
KP-N-YN GDSC1 -5.2701 -2.1073 -6.4863 16.4286
TGW GDSC1 -5.1593 -2.9823 -5.1806 37.4215
NH-12 GDSC1 -5.0257 -3.1991 -5.7254 9.5827
SJNB-14 GDSC1 -5.0229 -3.7985 -5.4314 7.2927
SJNB-13 GDSC1 -4.9052 -3.5005 -5.4667 7.0665
SJNB-12 GDSC1 -4.8542 -3.2866 -5.5269 7.3336
SJNB-6 GDSC1 -4.7614 -0.0002 -7.0883 18.5938
CHP-126 GDSC1 -4.5709 -0.6262 -6.617 14.6378
SiMa GDSC1 -4.569 -1.9637 -5.9471 9.5778
LA-N-6 GDSC1 -4.3232 1.28 -7.3684 18.7605
SK-N-FI GDSC1 -4.0444 2.5504 -7.7804 20.1863
SJNB-7 GDSC1 -0.0589 17.809 -12.3451 26.0957
SJNB-17 GDSC1 0.075 2.409 -5.4227 0.15
NB(TU)1 GDSC1 0.5524 2.5674 -5.3176 0.0381
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -5.3124 -2.6001 -6.2849 15.1063
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AU565 GDSC1 -11.4945 0.5836 -12.8496 76.7343
HCC1395 GDSC1 -7.6252 -3.7117 -8.2024 39.4425
HCC1143 GDSC1 -7.5161 2.5826 -10.8802 44.0649
HCC1187 GDSC1 -7.5131 -6.6539 -7.5137 35.4126
MDA-MB-361 GDSC1 -7.4815 -6.2663 -7.4884 35.0569
HCC1806 GDSC1 -7.2894 -6.1994 -7.2945 32.6443
MFM-223 GDSC1 -7.2451 -4.0483 -7.2767 54.5613
Evsa-T GDSC1 -7.1507 -5.2359 -7.2475 31.4822
MDA-MB-468 GDSC1 -7.1365 -6.1043 -7.1416 30.7334
HCC1954 GDSC1 -7.1335 -3.1509 -7.8885 34.8331
BT-549 GDSC1 -7.1295 -4.0402 -7.5518 33.1151
OCUB-M GDSC1 -7.0436 -5.2904 -7.1221 30.0345
JIMT-1 GDSC1 -7.0286 -5.4737 -7.0781 29.6649
CAL-51 GDSC1 -6.9542 -5.1229 -7.0566 29.0719
CAMA-1 GDSC1 -6.9342 -5.039 -7.0522 28.9213
HCC38 GDSC1 -6.774 -3.7293 -7.2807 29.3829
CAL-120 GDSC1 -6.7619 -3.7603 -7.2561 29.1626
MRK-nu-1 GDSC1 -6.6677 -4.3187 -6.9577 26.7282
COLO 824 GDSC1 -6.4448 -2.9507 -7.2502 27.3294
Hs 578T GDSC1 -6.3036 -4.0927 -6.6411 22.5537
EFM-19 GDSC1 -6.2745 -3.4934 -6.8435 23.7792
MCF-7 GDSC1 -6.2196 -3.4253 -6.8143 23.2897
BT-20 GDSC1 -5.9417 -0.8954 -7.7049 27.3641
MDA-MB-436 GDSC1 -5.9186 -2.6553 -6.8473 21.9804
EFM-192A GDSC1 -5.6765 -1.3906 -7.2146 23.2495
MDA-MB-231 GDSC1 -5.6345 -0.1857 -7.7652 26.2616
MDA-MB-453 GDSC1 -5.5542 -3.258 -6.2065 15.6113
CAL-85-1 GDSC1 -5.0791 -2.1233 -6.3047 14.2722
HCC1569 GDSC1 -4.7373 -0.0556 -7.0404 18.1869
MDA-MB-157 GDSC1 -4.6673 1.8584 -7.9389 23.2319
MDA-MB-415 GDSC1 -4.6445 -1.4276 -6.277 12.3868
HCC70 GDSC1 -4.1754 2.9429 -8.0798 22.2047
BT-474 GDSC1 -4.1663 -0.7137 -6.2532 10.5759
HCC2157 GDSC1 -4.073 0.2618 -4.6765 30.7833
HCC202 GDSC1 -4.0309 1.7948 -7.3939 17.9158
UACC-893 GDSC1 -3.7331 3.7594 -8.1392 21.0502
MDA-MB-330 GDSC1 -3.4334 1.4987 -6.8025 12.2716
HCC1500 GDSC1 -2.072 7.1788 -8.602 18.5882
HCC1937 GDSC1 -1.6522 4.4373 -7.031 9.3763
HCC1428 GDSC1 -1.0929 5.4461 -7.1585 8.9968
HDQ-P1 GDSC1 -0.7547 6.9638 -7.6474 10.9776
HCC1419 GDSC1 -0.4856 3.0615 -5.8583 1.4372
DU4475 GDSC1 -0.4368 3.4405 -5.9815 1.8853
HCC1599 GDSC1 -0.2668 10.5632 -5.9598 29.9133
T-47D GDSC1 -0.1144 3.5625 -5.8941 1.312
BT-483 GDSC1 0.1033 3.6433 -5.838 1.0012
MDA-MB-175-VII GDSC1 0.1109 2.8803 -5.5681 0.3475
ZR-75-30 GDSC1 0.3554 3.4765 -5.6853 0.5034
HCC2218 GDSC1 1.4319 11.5919 -5.1558 17.1292
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PFSK-1 GDSC1 -10.3128 -3.7339 -10.5435 84.3662
Becker GDSC1 -8.4772 -6.1882 -8.5302 47.5673
YH-13 GDSC1 -8.1537 -6.508 -8.1681 43.4845
DK-MG GDSC1 -7.9111 -4.6882 -8.204 41.6091
U-251MG GDSC1 -7.6814 -5.883 -7.7222 37.7487
Daoy GDSC1 -7.6768 -6.2664 -7.6888 37.5275
SK-MG-1 GDSC1 -7.4439 -4.248 -7.8246 36.5886
MOG-G-UVW GDSC1 -7.4051 -6.2396 -7.4113 34.0976
H4 GDSC1 -7.3746 -6.4679 -7.3758 33.6848
GI-1 GDSC1 -7.2584 -6.2322 -7.2621 32.2488
SF539 GDSC1 -7.2029 -6.2545 -7.2054 31.5474
SF268 GDSC1 -7.1772 -3.5898 -7.765 34.5229
LNZTA3WT4 GDSC1 -7.1526 -4.8831 -7.3258 31.9694
D-247MG GDSC1 -7.0749 -4.4175 -7.3699 31.741
KALS-1 GDSC1 -6.9828 -3.2452 -7.6913 32.9323
SF126 GDSC1 -6.9727 -3.6725 -7.5149 31.9318
MOG-G-CCM GDSC1 -6.8853 -4.3418 -7.187 29.473
A-172 GDSC1 -6.8767 -4.7086 -7.0696 28.684
Hs 683 GDSC1 -6.8362 -5.4659 -6.8744 27.1897
NMC-G1 GDSC1 -6.7927 -1.9644 -8.0409 33.4759
M059J GDSC1 -6.2388 -3.0001 -7.0165 24.7428
SF295 GDSC1 -6.0982 -1.2258 -7.6957 28.0789
GaMG GDSC1 -6.0774 -4.6878 -6.203 18.2863
T98G GDSC1 -6.0772 -4.4523 -6.2727 18.7614
LN-229 GDSC1 -6.0484 -4.7702 -6.1498 17.7614
YKG-1 GDSC1 -5.9252 -3.107 -6.6486 20.6284
KNS-42 GDSC1 -5.7672 -3.2763 -6.4124 18.1523
SW1783 GDSC1 -5.7156 3.3739 -7.6387 55.7992
D-423MG GDSC1 -5.6972 -2.5841 -6.662 19.6196
D-336MG GDSC1 -5.6453 -3.0346 -6.4003 17.4775
KS-1 [Human Krukenberg tumour] GDSC1 -5.6395 -0.8169 -7.4599 24.573
DBTRG-05MG GDSC1 -5.5857 -3.655 -6.0591 14.6653
KINGS-1 GDSC1 -5.5468 -1.7663 -6.9103 20.66
LN-18 GDSC1 -5.5132 -3.9832 -5.8426 12.7101
SNB-75 GDSC1 -5.4199 -1.4663 -6.9388 20.2899
ONS-76 GDSC1 -5.2667 -2.7798 -6.1547 13.9201
D-542MG GDSC1 -4.9691 -1.3587 -6.5875 15.933
SW1088 GDSC1 -4.8787 -2.4413 -5.9692 10.8935
D-263MG GDSC1 -4.8356 2.2969 -8.2992 25.6396
Onda 10 GDSC1 -4.7499 1.1557 -7.6565 22.0115
D-502MG GDSC1 -4.7495 -1.8263 -6.1655 11.9221
U-118MG GDSC1 -4.6277 -2.1006 -5.9266 9.6263
U-87MG ATCC GDSC1 -4.5543 -2.7982 -5.5185 6.167
D283 Med GDSC1 -4.5329 -2.3443 -5.7279 7.7396
Onda 11 GDSC1 -4.2977 4.2608 -8.8362 26.0617
8-MG-BA GDSC1 -4.2394 1.4053 -7.364 18.4413
D-392MG GDSC1 -4.1661 3.6043 -8.4023 23.7328
LN-405 GDSC1 -4.1647 0.8819 -7.0443 16.1617
KNS-81-FD GDSC1 -3.8029 6.053 -9.3345 26.3905
42-MG-BA GDSC1 -0.662 5.8313 -7.0857 7.8139
CAS-1 GDSC1 -0.4204 5.862 -6.9676 6.7773
AM-38 GDSC1 0.1439 5.191 -6.409 3.2083
D-566MG GDSC1 0.2883 2.6531 -5.4317 0.1323
GB-1 GDSC1 0.5319 2.8594 -5.4185 0.0962
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -6.8045 -3.5544 -7.3802 30.1526
TGBC24TKB GDSC1 -5.4044 -3.6148 -5.8931 12.5548
TGBC1TKB GDSC1 -5.2877 -2.2142 -6.4501 16.2359
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 -7.3597 -6.3781 -7.3619 33.5054
ESS-1 GDSC1 -7.1987 -6.2073 -7.2021 31.5001
MFE-296 GDSC1 -7.0733 -5.0449 -7.2021 30.7174
RL95-2 GDSC1 -7.0423 -5.9565 -7.0506 29.576
MFE-280 GDSC1 -4.8961 -2.8277 -5.7921 9.5783
AN3-CA GDSC1 -4.8655 -3.2827 -5.5389 7.4722
KLE GDSC1 -3.8118 1.2435 -6.9533 14.4123
EN GDSC1 -0.5016 6.0719 -7.103 7.6339
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC1 -7.5173 -6.1322 -7.5312 35.5467
769-P GDSC1 -7.2578 -1.4609 -8.7386 38.7812
786-O GDSC1 -7.1223 -3.4355 -7.7649 34.1716
RXF 393L GDSC1 -6.9942 -1.6642 -8.3799 36.0263
KTCTL-140 GDSC1 -6.8277 -4.1138 -7.1998 29.2066
BFTC-909 GDSC1 -6.5577 -4.3481 -6.8287 25.2453
NCC010 GDSC1 -6.1381 -3.6 -6.6564 21.7708
SN12C GDSC1 -5.9328 -3.2059 -6.6124 20.41
LB996-RCC GDSC1 -5.7994 -2.559 -6.774 20.8952
LB2241-RCC GDSC1 -5.3795 -2.3091 -6.4893 16.9243
KTCTL-21 GDSC1 -5.1844 -1.2209 -6.8462 18.648
LB1047-RCC GDSC1 -5.1321 -1.1715 -6.8241 18.2776
KTCTL-13 GDSC1 -4.9636 -2.9702 -5.7817 9.7665
KTCTL-195 GDSC1 -4.9118 -1.5522 -6.4413 14.6311
BB65-RCC GDSC1 -4.8039 -1.681 -6.2842 13.034
KMRC-1 GDSC1 -4.7197 -2.8402 -5.6335 7.6593
UO-31 GDSC1 -4.7178 -0.5259 -6.7889 16.4006
KTCTL-26A GDSC1 -4.6648 -3.1201 -5.4475 5.9936
KTCTL-1M GDSC1 -4.6408 -2.2709 -5.8523 9.0924
VMRC-RCZ GDSC1 -4.6364 -1.3851 -6.2915 12.4678
HA7-RCC GDSC1 -4.604 -0.9443 -6.4852 13.7971
KMRC-20 GDSC1 -4.5709 -2.4883 -5.6865 7.5453
TK-10 GDSC1 -4.543 -1.1644 -6.3252 12.3863
A-498 GDSC1 -4.4921 0.448 -7.0894 17.6011
CAL-54 GDSC1 -4.3301 -0.5814 -6.4458 12.5462
RCC10RGB GDSC1 -4.1541 -0.3895 -6.4046 11.66
ACHN GDSC1 -3.9478 0.2285 -6.5542 12.0889
OS-RC-2 GDSC1 -3.4817 2.3348 -7.2461 15.2763
Caki-1 GDSC1 -3.1719 1.3706 -6.5598 9.9088
A-704 GDSC1 -3.1334 2.3386 -6.9992 12.7211
NCC021 GDSC1 -1.0011 2.4673 -5.8494 1.8184
SW156 GDSC1 -0.1762 3.1023 -5.7507 0.8856
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1 -9.1415 -6.962 -9.1634 55.5566
GP5d GDSC1 -7.8318 -6.7379 -7.8336 39.4039
MDST8 GDSC1 -7.4091 -6.5227 -7.4101 34.1153
SNU-407 GDSC1 -7.4032 -6.1427 -7.4131 34.0969
SW48 GDSC1 -7.1568 -5.4189 -7.223 31.3683
SK-CO-1 GDSC1 -7.1094 -4.933 -7.2668 31.3405
HCC2998 GDSC1 -6.9634 -4.6159 -7.1899 29.965
RKO GDSC1 -6.9233 -3.394 -7.5692 31.9265
SW620 GDSC1 -6.4761 -2.5149 -6.6152 48.4248
SNU-C5 GDSC1 -6.1689 -3.2619 -6.8308 23.1356
LS513 GDSC1 -5.994 -3.8202 -6.4149 19.314
CCK-81 GDSC1 -5.7956 -4.1698 -6.067 15.79
HT115 GDSC1 -5.5416 -4.5033 -5.6739 11.6496
SNU-81 GDSC1 -5.456 -2.3866 -6.5239 17.5164
HT-29 GDSC1 -5.4338 -0.1961 -6.0074 41.2282
SW626 GDSC1 -5.4183 -1.5323 -6.9049 20.0517
LoVo GDSC1 -5.3508 -2.4314 -6.4029 16.1579
COLO 320HSR GDSC1 -5.1256 -3.2327 -5.802 10.6003
CaR-1 GDSC1 -5.1073 -2.8423 -5.9756 11.8652
DiFi GDSC1 -5.0426 -2.9679 -5.8545 10.6567
LS180 GDSC1 -4.7945 -1.884 -6.1748 12.1629
SNU-C2B GDSC1 -4.7527 -0.9151 -6.6236 15.3572
COLO205 GDSC1 -4.7085 -1.3903 -6.349 13.1656
SW948 GDSC1 -4.5866 -2.1245 -5.881 9.1249
KM12 GDSC1 -4.4248 0.8579 -7.2395 18.3217
LS411N GDSC1 -4.1257 0.4724 -6.8104 14.4592
RCM-1 [Human ESC] GDSC1 -3.8486 -1.5241 -5.6308 4.9612
CL-11 GDSC1 -3.4998 -0.0557 -6.0983 7.5044
HT-55 GDSC1 -3.4321 1.2326 -6.6723 11.3854
SNU-1040 GDSC1 -3.3017 3.142 -7.5106 16.3291
NCI-H716 GDSC1 -2.4743 3.2114 -4.2666 23.2866
LS1034 GDSC1 -0.6548 3.7777 -6.2113 3.1492
SW837 GDSC1 -0.5661 3.0669 -5.8937 1.6354
NCI-H747 GDSC1 -0.5529 12.0468 -9.9045 20.2682
SNU-61 GDSC1 -0.5419 7.7684 -7.8874 11.7815
SW1463 GDSC1 -0.4615 3.3616 -5.9618 1.8251
SW1116 GDSC1 -0.2474 2.7859 -5.6648 0.6798
HCT 15 GDSC1 -0.2178 2.3061 -5.4883 0.2918
CW-2 GDSC1 -0.1824 2.5143 -5.5467 0.3873
SW1417 GDSC1 -0.1315 2.9659 -5.6852 0.6833
COLO 678 GDSC1 -0.0808 4.9203 -6.4041 3.4294
NCI-H508 GDSC1 -0.0765 5.5777 -6.6706 4.7317
T84 GDSC1 0.0776 3.6328 -5.8441 1.0337
LS123 GDSC1 0.1315 3.9349 -5.9331 1.2893
C2BBe1 GDSC1 0.2603 3.5492 -5.7453 0.6739
SNU-C1 GDSC1 1.5798 13.5402 -6.0045 19.8107
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -4.3215 -0.2665 -6.5958 13.608
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -7.172 -5.232 -7.2713 31.762
SK-HEP-1 GDSC1 -7.1345 -6.4562 -7.1347 30.6775
JHH-6 GDSC1 -6.7768 -4.9079 -6.9104 27.0628
SNU-423 GDSC1 -5.9557 -2.3914 -7.0064 23.2354
Huh-7 GDSC1 -5.5612 -2.7753 -6.4391 17.3707
HLE GDSC1 -5.3938 -4.1551 -5.646 10.6689
JHH-2 GDSC1 -5.3581 -1.4301 -6.8999 19.7553
HuH-1 GDSC1 -5.25 -3.2364 -5.9186 12.0414
Hep 3B2.1-7 GDSC1 -5.1187 -0.2047 -7.2933 21.3164
JHH-1 GDSC1 -5.0209 -2.1458 -6.2415 13.5568
JHH-4 GDSC1 -4.9642 -3.1987 -5.6693 8.8911
JHH-7 GDSC1 -4.6471 -2.7581 -5.614 7.2424
SNU-449 GDSC1 -3.6187 -0.9241 -5.7646 5.3741
SNU-387 GDSC1 -3.0697 2.1892 -6.8832 11.7988
Hep-G2/C3A GDSC1 -0.225 5.2821 -6.621 4.6762
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 173 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 GDSC1 -9.1198 -7.3437 -9.1264 55.411
PC-14 GDSC1 -8.7526 -6.9986 -8.7527 67.2266
NCI-H661 GDSC1 -8.4531 -5.9295 -8.5361 47.3298
Calu-6 GDSC1 -8.1144 -4.2531 -8.5529 44.2595
NCI-H1792 GDSC1 -8.0028 -6.2542 -8.0269 41.6537
NCI-H524 GDSC1 -7.9874 -6.2472 -8.0114 41.4623
NCI-H69 GDSC1 -7.8017 -4.1183 -8.2553 40.9317
NCI-H211 GDSC1 -7.5628 -4.0774 -8.0092 38.2433
NCI-H1437 GDSC1 -7.5356 -3.2917 -7.6435 75.7674
HCC44 GDSC1 -7.5192 -6.3715 -7.5237 35.513
NCI-H647 GDSC1 -7.4586 -4.2547 -7.8384 36.7549
NCI-H2122 GDSC1 -7.3926 -6.326 -7.3962 33.925
LCLC-97TM1 GDSC1 -7.3364 -5.6532 -7.3828 33.4852
LK-2 GDSC1 -7.3297 -6.3715 -7.3317 33.1284
LOU-NH91 GDSC1 -7.2975 -6.1408 -7.3048 32.7597
HARA [Human squamous cell lung carcinoma] GDSC1 -7.2764 -6.3832 -7.2778 32.459
A-549 GDSC1 -7.2651 -2.8362 -7.4131 54.4023
NCI-H2110 GDSC1 -7.2586 -4.7676 -7.4707 33.4966
EMC-BAC-1 GDSC1 -7.2132 -4.3299 -7.5477 33.6313
EMC-BAC-2 GDSC1 -7.2125 -5.3377 -7.296 32.1683
NCI-H446 GDSC1 -7.1879 -5.4433 -7.2527 31.7474
NCI-H2595 GDSC1 -7.1846 -3.5648 -7.7824 34.6557
NCI-H1915 GDSC1 -7.1475 -5.9829 -7.1575 30.9021
VMRC-LCD GDSC1 -7.1392 -6.114 -7.144 30.7656
NCI-H2722 GDSC1 -7.1288 -1.4422 -8.6161 37.6368
LC-2/ad GDSC1 -7.0626 -4.6274 -7.2948 31.2176
NCI-H2369 GDSC1 -7.0443 -4.7728 -7.2356 30.7446
NCI-H838 GDSC1 -7.0438 -4.5774 -7.2885 31.0635
NCI-H2009 GDSC1 -7.0253 -4.5646 -7.272 30.8491
DMS 273 GDSC1 -7.0245 -4.6838 -7.2376 30.6341
NCI-H841 GDSC1 -7.0239 -5.6268 -7.055 29.4898
A-427 GDSC1 -7.0152 -5.2836 -7.0927 29.674
UMC-11 GDSC1 -6.9938 -4.5911 -7.23 30.3982
CPC-N GDSC1 -6.97 -4.4966 -7.2317 30.2628
COR-L279 GDSC1 -6.9281 -4.8977 -7.0777 29.0462
NCI-H358 GDSC1 -6.8739 -4.6827 -7.0736 28.6931
NCI-H290 GDSC1 -6.8534 -4.5071 -7.1014 28.7456
NCI-H23 GDSC1 -6.84 -5.2747 -6.9057 27.4127
NCI-H522 GDSC1 -6.8212 -4.4896 -7.0715 28.364
RERF-LC-MS GDSC1 -6.8126 -4.9027 -6.9507 27.5374
NCI-H292 GDSC1 -6.7368 -4.343 -7.0251 27.5678
LXF 289 GDSC1 -6.735 -4.739 -6.9069 26.7919
EPLC-272H GDSC1 -6.53 -1.722 -7.8867 31.2953
NCI-H1975 GDSC1 -6.5029 -4.0012 -6.8889 25.3353
NCI-H2373 GDSC1 -6.5004 0.1877 -8.7586 34.7303
NCI-H1573 GDSC1 -6.4058 -0.6327 -8.2754 32.4041
NCI-H2030 GDSC1 -6.106 -3.0565 -6.8555 22.9779
NCI-H1648 GDSC1 -6.1032 -1.9395 -6.3082 45.5944
HOP-62 GDSC1 -6.0213 0.6645 -8.5387 31.6196
EBC-1 GDSC1 -5.9988 -4.3081 -6.2357 18.0727
NCI-H3122 GDSC1 -5.9935 -3.4049 -6.5878 20.5413
ChaGo-K-1 GDSC1 -5.9848 -3.4288 -6.5686 20.3611
SBC-3 GDSC1 -5.9514 -3.7382 -6.4033 19.0107
NCI-H1436 GDSC1 -5.892 -1.8741 -7.1876 24.0967
DMS 114 GDSC1 -5.887 -3.6342 -6.3794 18.5094
NCI-H1944 GDSC1 -5.8865 -2.8133 -6.7427 21.099
SK-MES-1 GDSC1 -5.8585 -0.2835 -7.9241 28.1091
NCI-H2731 GDSC1 -5.8291 -2.0122 -7.0611 22.9799
NCI-H1781 GDSC1 -5.8031 -2.2761 -6.9107 21.8529
SHP-77 GDSC1 -5.7554 -4.0991 -6.0512 15.4659
ABC-1 GDSC1 -5.6549 -4.0234 -5.9747 14.3933
COR-L23 GDSC1 -5.6195 -2.7826 -6.4926 18.0336
SBC-5 GDSC1 -5.5875 -4.6879 -5.6683 11.8688
NCI-H1355 GDSC1 -5.506 -0.7882 -7.3511 23.3238
NCI-H2087 GDSC1 -5.4831 -2.4068 -6.54 17.7553
CAL-12T GDSC1 -5.4707 -3.7683 -5.8914 12.8599
HOP-92 GDSC1 -5.4669 -2.8421 -6.3159 16.0256
IST-SL1 GDSC1 -5.4564 -1.7622 -6.8277 19.6879
NCI-H209 GDSC1 -5.4526 -1.844 -6.7842 19.3674
NCI-H1341 GDSC1 -5.4235 -2.0122 -6.6751 18.4664
NCI-H1048 GDSC1 -5.39 -4.3258 -5.574 10.1284
HCC366 GDSC1 -5.381 -2.3134 -6.4886 16.9254
NCI-H2818 GDSC1 -5.354 -3.3984 -5.943 12.6971
NCI-H810 GDSC1 -5.3513 -3.1133 -6.075 13.6875
NCI-H847 GDSC1 -5.3325 -4.4749 -5.4571 8.9925
HCC15 GDSC1 -5.3267 -3.4756 -5.8801 12.0943
NCI-H650 GDSC1 -5.3104 -2.7321 -6.219 14.5991
LC-1/sq GDSC1 -5.3049 -2.2593 -6.4439 16.264
NCI-H2170 GDSC1 -5.2988 -1.9066 -6.6112 17.4647
NCI-H1299 GDSC1 -5.2906 -2.2462 -6.4371 16.1521
NCI-H3255 GDSC1 -5.2706 0.0813 -7.5694 23.5967
NCI-H82 GDSC1 -5.2689 -2.3272 -6.3774 15.6135
NCI-H460 GDSC1 -5.2361 -4.3845 -5.3872 7.9821
Lu-99A GDSC1 -5.2348 -2.0156 -6.499 16.3717
NCI-H2461 GDSC1 -5.2208 0.9243 -7.9449 25.4256
NCI-H1755 GDSC1 -5.1945 -0.9723 -6.9785 19.5932
RERF-LC-KJ GDSC1 -5.1709 -2.0492 -6.4242 15.5496
SW1271 GDSC1 -5.1399 -1.9321 -6.4541 15.6426
SBC-1 GDSC1 -5.0899 -0.1164 -5.6571 38.6206
NCI-H226 GDSC1 -5.008 -2.5436 -6.0327 11.8991
NCI-H520 GDSC1 -4.992 -2.0411 -6.2679 13.6415
RERF-LC-Sq1 GDSC1 -4.979 -1.6364 -6.4579 15.0191
NCI-H1155 GDSC1 -4.9744 -3.6372 -5.4635 7.3309
NCI-H1993 GDSC1 -4.9368 -2.3394 -6.0708 11.9102
NCI-H1581 GDSC1 -4.8981 -3.5607 -5.4306 6.7555
Ms-1 GDSC1 -4.8576 -3.3256 -5.5106 7.2194
PaCa-3 GDSC1 -4.8126 -1.4828 -6.3906 13.8694
NCI-H1876 GDSC1 -4.7987 3.8603 -9.0497 28.6375
Lu-135 GDSC1 -4.7755 -1.2682 -6.4664 14.2935
LCLC-103H GDSC1 -4.7638 3.4441 -8.8124 27.5937
NCI-H1568 GDSC1 -4.7226 0.9864 -7.5491 21.2933
NCI-H720 GDSC1 -4.7126 0.9111 -7.503 20.9862
NCI-H2227 GDSC1 -4.7029 0.3797 -7.2292 19.2784
NCI-H1666 GDSC1 -4.6969 -1.5893 -6.2397 12.2957
DMS 53 GDSC1 -4.6893 -1.3633 -6.3464 13.0749
NCI-H1651 GDSC1 -4.6458 -2.6708 -5.6565 7.5727
NCI-H596 GDSC1 -4.6152 -1.453 -6.2401 12.0006
NCI-H2228 GDSC1 -4.6091 -1.5145 -6.2043 11.7061
NCI-H2023 GDSC1 -4.5688 -2.2046 -5.8266 8.6365
NCI-H1793 GDSC1 -4.5394 -0.6539 -6.5773 14.2374
COR-L321 GDSC1 -4.5363 -2.035 -5.885 8.9805
KNS-62 GDSC1 -4.5289 -2.2977 -5.7479 7.8826
SW1573 GDSC1 -4.4186 -0.3911 -6.6109 14.0521
NCI-H2172 GDSC1 -4.4178 -2.3302 -5.6445 6.7021
NCI-H2066 GDSC1 -4.3722 0.7979 -7.1672 17.6756
SK-LU-1 GDSC1 -4.3633 3.4244 -8.4717 24.7231
NCI-H1688 GDSC1 -4.3225 -0.4866 -6.487 12.8226
NCI-H835 GDSC1 -4.251 2.6528 -7.9956 22.0345
NCI-H1770 GDSC1 -4.2073 2.673 -7.9707 21.7545
NCI-H2029 GDSC1 -4.1944 -0.8509 -6.2067 10.3162
NCI-H1563 GDSC1 -4.1555 1.7844 -7.4865 18.8884
Lu-134-A GDSC1 -4.0744 2.6912 -7.8741 20.7939
Lu-139 GDSC1 -3.9672 1.7703 -7.3324 17.3309
NCI-H513 GDSC1 -3.7597 0.0485 -6.3284 9.8922
NCI-H2085 GDSC1 -3.7537 1.1528 -6.8653 13.645
NCI-H1105 GDSC1 -3.7506 1.2483 -6.9101 13.9349
HCC78 GDSC1 -3.746 0.075 -6.3315 9.8756
NCI-H196 GDSC1 -3.7129 4.3189 -8.4013 22.2532
NCI-H2591 GDSC1 -3.6515 0.1212 -6.2872 9.2843
COR-L105 GDSC1 -3.6297 0.7824 -6.5934 11.4057
COLO 668 GDSC1 -3.6205 2.8596 -7.6076 17.8512
Lu-165 GDSC1 -3.4324 2.2363 -7.1618 14.6046
NCI-H2804 GDSC1 -2.9384 10.2655 -8.1315 43.062
NCI-H2795 GDSC1 -2.6201 25.1972 -15.2678 45.9783
NCI-H2869 GDSC1 -2.3038 4.6583 -7.5484 13.8516
NCI-H2342 GDSC1 -2.261 3.6906 -7.0623 10.9027
NCI-H441 GDSC1 -2.0385 8.251 -9.0985 20.6199
NCI-H1092 GDSC1 -1.5387 3.4549 -6.5244 6.1514
NCI-H727 GDSC1 -1.2125 3.7866 -6.4926 5.4202
NCI-H1623 GDSC1 -1.1451 6.7977 -7.8089 12.6039
HCC827 GDSC1 -0.8434 3.8175 -6.3178 3.9234
IA-LM GDSC1 -0.8173 3.0911 -6.0119 2.3716
BEN GDSC1 -0.8141 6.0983 -7.2906 9.1984
NCI-H1838 GDSC1 -0.7401 2.9591 -5.9265 1.9171
IST-SL2 GDSC1 -0.7144 6.5362 -7.4298 9.7585
NCI-H2291 GDSC1 -0.6541 4.2185 -6.391 4.0577
NCI-H526 GDSC1 -0.4926 2.7949 -5.7623 1.0997
NCI-H2444 GDSC1 -0.478 3.9156 -6.185 2.8271
NCI-H1694 GDSC1 -0.3932 4.0819 -6.2126 2.8662
DMS 79 GDSC1 -0.3829 2.0347 -5.4541 0.2739
NCI-H1650 GDSC1 -0.3595 6.5619 -7.24 8.1217
NCI-H2810 GDSC1 -0.2911 2.7795 -5.679 0.7371
NCI-H2803 GDSC1 -0.2769 3.3579 -5.8838 1.3842
NCI-H2347 GDSC1 -0.2733 3.1107 -5.7913 1.0644
COR-L88 GDSC1 -0.2496 5.811 -6.856 5.9256
NCI-H1435 GDSC1 -0.1845 3.6534 -5.9565 1.5871
NCI-H2405 GDSC1 -0.143 3.8306 -6.006 1.746
COR-L32 GDSC1 -0.1154 3.4381 -5.8488 1.1589
NCI-H187 GDSC1 -0.0934 3.5464 -5.8798 1.2494
NCI-H2081 GDSC1 -0.0782 6.9108 -7.2389 7.6526
NCI-H2141 GDSC1 -0.0758 4.1093 -6.0837 2.0013
LB647-SCLC GDSC1 -0.0622 2.504 -5.5011 0.277
NCI-H1836 GDSC1 0.0389 1.6308 -5.1831 0.0134
NCI-H146 GDSC1 0.0548 3.6856 -5.8722 1.1347
Calu-3 GDSC1 0.0552 6.8862 -7.157 7.0231
NCI-H345 GDSC1 0.1901 3.8049 -5.8628 1.0303
EKVX GDSC1 0.2071 4.192 -5.9977 1.4633
NCI-H322M GDSC1 0.2346 7.9941 -7.542 8.6775
NCI-H1869 GDSC1 0.3 3.7837 -5.8133 0.8332
COR-L95 GDSC1 0.3388 2.7062 -5.4323 0.127
NCI-H1304 GDSC1 0.437 3.4063 -5.6323 0.3776
NCI-H2135 GDSC1 0.5313 2.3652 -5.2597 0.0202
Lu-65 GDSC1 1.6728 9.9884 -4.2019 12.857
⏷ Show the Full List of 173 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -4.9679 0.0095 -7.269 20.5557
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-410 GDSC1 -9.6629 4.4687 -12.2478 67.9629
OE21 GDSC1 -8.8036 -4.8722 -9.1293 51.2424
EC-GI-10 GDSC1 -8.2338 -6.666 -8.2435 44.4612
KYSE-450 GDSC1 -7.4829 -6.2504 -7.4904 35.0782
TE-4 GDSC1 -7.3007 -5.9762 -7.3161 32.8501
TE-11 GDSC1 -7.2879 -6.2018 -7.2929 32.6251
TE-10 GDSC1 -7.2471 -6.0904 -7.255 32.1335
KYSE-180 GDSC1 -7.2464 -6.2968 -7.2487 32.0898
TE-9 GDSC1 -7.136 -6.087 -7.1416 30.7303
KYSE-510 GDSC1 -7.051 -6.012 -7.0573 29.6724
TE-5 GDSC1 -6.8612 -4.0983 -7.2414 29.6625
TE-1 GDSC1 -6.6916 -4.3235 -6.9821 27.0259
TE-8 GDSC1 -6.6696 -4.7041 -6.8449 26.0011
T.T GDSC1 -6.0328 5.0546 -10.7163 37.7696
KYSE-270 GDSC1 -4.903 -1.6941 -6.3629 14.0094
KYSE-150 GDSC1 -4.7186 -3.314 -5.3957 5.7812
KYSE-70 GDSC1 -4.6796 -0.6164 -6.7117 15.714
KYSE-520 GDSC1 -4.313 4.7903 -9.1132 27.1986
TE-15 GDSC1 -4.1062 -0.0686 -6.527 12.3968
COLO 680N GDSC1 -3.5124 1.7519 -6.9827 13.6943
OE33 GDSC1 -0.6838 3.1 -5.9566 1.9961
TE-6 GDSC1 -0.4243 3.0099 -5.8143 1.235
KYSE-140 GDSC1 -0.069 24.9141 -12.9702 40.1003
OE19 GDSC1 0.4598 4.0453 -5.8461 0.8495
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 -7.8758 -6.969 -7.8761 39.9447
TOV-112D GDSC1 -7.468 -5.8503 -7.5007 35.0442
TOV-21G GDSC1 -7.3631 -4.4414 -7.6767 35.3073
A2780 GDSC1 -7.3275 -6.2914 -7.3309 33.1099
JHOS-2 GDSC1 -7.1978 -6.3121 -7.1994 31.4775
OVCAR-8 GDSC1 -7.1193 -5.836 -7.137 30.5974
OVTOKO GDSC1 -7.1159 -1.8133 -8.4373 36.953
DOV13 GDSC1 -6.8177 -3.1271 -7.5649 31.2709
OVCAR-5 GDSC1 -6.799 -4.343 -7.0927 28.3666
OVCAR-3 GDSC1 -6.4852 -4.3368 -6.7536 24.3309
SK-OV-3 GDSC1 -5.8018 -1.0818 -7.4824 25.455
OVCAR-4 GDSC1 -5.6032 -2.4333 -6.6423 19.0414
OVK18 GDSC1 -5.4415 -3.3331 -6.0598 13.9842
RMG-I GDSC1 -4.9225 -1.2247 -6.614 15.9412
JHOS-4 GDSC1 -4.8231 -2.8595 -5.7123 8.6692
ES-2 GDSC1 -4.823 -3.5092 -5.3887 6.1256
EFO-27 GDSC1 -4.7967 -1.9018 -6.1678 12.1171
OAW42 GDSC1 -4.7083 -2.2864 -5.9007 9.716
OV56 GDSC1 -4.6722 -3.3903 -5.3186 5.0036
TYK-nu GDSC1 -4.6623 -2.1402 -5.9354 9.8193
OAW28 GDSC1 -4.5837 -1.9521 -5.9648 9.7675
Kuramochi GDSC1 -4.5629 -1.1733 -6.337 12.5466
EFO-21 GDSC1 -4.3335 0.2057 -6.8407 15.3717
Caov-4 GDSC1 -4.108 -0.9177 -6.1086 9.3038
OV-90 GDSC1 -3.8327 -0.6395 -6.0454 8.0146
OVISE GDSC1 -3.6378 0.9906 -6.7009 12.1755
FU-OV-1 GDSC1 -0.7245 6.4669 -7.4044 9.6429
OVKATE GDSC1 -0.3531 4.035 -6.1759 2.6552
IGROV-1 GDSC1 0.2595 2.497 -5.3902 0.0991
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T3 GDSC1 -8.85 20.335 -18.5844 57.7314
KP-1N GDSC1 -7.4824 -3.7342 -8.0404 37.8068
MIA PaCa-2 GDSC1 -7.2219 -5.8253 -7.2448 31.9116
Panc 03.27 GDSC1 -7.0995 -6.2007 -7.1017 30.2528
HuP-T4 GDSC1 -7.007 1.1473 -8.1574 63.9801
DAN-G GDSC1 -6.93 -3.8685 -7.3968 31.0025
KP-4 GDSC1 -6.5267 -4.45 -6.7626 24.6277
PaTu 8988t GDSC1 -6.2434 -4.3691 -6.4803 21.1153
PSN1 GDSC1 -5.6047 -2.9128 -6.4169 17.4095
BxPC-3 GDSC1 -5.5251 -1.8986 -6.8256 19.9798
SU.86.86 GDSC1 -5.3714 -1.2456 -7.0029 20.5092
MZ-PC-1 GDSC1 -5.3515 -2.3291 -6.4534 16.5364
Panc 02.03 GDSC1 -5.2948 -2.2183 -6.4546 16.2999
CFPAC-1 GDSC1 -4.945 -2.2287 -6.1332 12.4243
PaTu 8902 GDSC1 -4.8758 -3.7126 -5.3354 5.9206
KP-2 GDSC1 -4.8641 -3.416 -5.4715 6.9385
KP-3 GDSC1 -4.8206 -1.1711 -6.5532 15.1043
HPAF-II GDSC1 -4.6625 -2.2015 -5.905 9.5824
Panc 10.05 GDSC1 -4.5563 -1.24 -6.2983 12.2309
Panc 08.13 GDSC1 -4.2697 -1.6533 -5.8668 7.9581
SUIT-2 GDSC1 -4.0877 -0.0572 -6.5185 12.2763
SW1990 GDSC1 -3.9447 0.8524 -6.8601 14.209
PL4 GDSC1 -3.8146 1.9387 -7.299 16.6315
Hs 766T GDSC1 -1.6087 4.4509 -7.0111 9.1703
QGP-1 GDSC1 -1.1902 5.4772 -7.2296 9.5822
Panc 04.03 GDSC1 -0.6415 10.5961 -9.2717 18.1278
YAPC GDSC1 -0.4264 2.9986 -5.8109 1.2247
HPAC GDSC1 -0.4101 3.7743 -6.099 2.3651
Capan-1 GDSC1 -0.0442 7.4856 -4.2444 22.5968
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 -8.58 -0.4194 -9.3736 72.4282
NCI-H2452 GDSC1 -7.163 -5.6364 -7.2009 31.2695
MPP 89 GDSC1 -4.4733 0.2866 -6.9935 16.9006
NCI-H28 GDSC1 -3.5233 28.956 -17.9282 48.0598
IST-Mes1 GDSC1 0.7909 16.6473 -8.149 32.3043
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 -7.1143 -4.7239 -7.3248 31.7218
VCaP GDSC1 -5.8797 -4.2242 -6.137 16.7351
DU145 GDSC1 -5.8229 -3.8983 -6.2027 16.9061
22Rv1 GDSC1 -5.3235 -2.046 -6.5656 17.2391
PC-3 GDSC1 -5.1306 -2.0175 -6.4034 15.2263
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -4.7682 -2.6326 -5.7784 8.9796
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGR-1 GDSC1 -9.8876 -3.7292 -10.0898 83.7524
WM115 GDSC1 -8.1227 -4.5502 -8.4734 44.1428
COLO 800 GDSC1 -7.8938 -6.806 -7.8953 40.177
SK-MEL-2 GDSC1 -7.6725 -4.6318 -7.6901 58.044
WM793 GDSC1 -7.671 -3.5483 -8.3107 40.1497
M14 GDSC1 -7.6281 -6.2169 -7.6282 57.9042
CP50-MEL-B GDSC1 -7.563 -6.4078 -7.5674 36.0601
WM1552C GDSC1 -7.4715 -6.0116 -7.4911 35.0093
RPMI-7951 GDSC1 -7.3444 -1.4213 -7.7646 70.0158
RVH-421 GDSC1 -7.1762 -5.0496 -7.313 32.0419
HT-144 GDSC1 -7.0527 -5.1927 -7.1497 30.2639
IGR-37 GDSC1 -6.9957 -5.8069 -7.0105 29.0345
WM35 GDSC1 -6.9293 -4.5162 -7.1815 29.705
G-mel GDSC1 -6.9212 -4.3361 -7.2278 29.9411
LOX-IMVI GDSC1 -6.9109 -4.0001 -6.9346 51.8887
CP66-MEL GDSC1 -6.8985 -4.1821 -7.2534 29.9596
COLO 792 GDSC1 -6.7848 -4.8443 -6.9344 27.2653
A-431 GDSC1 -6.7662 -4.3514 -7.0543 27.9282
G-361 GDSC1 -6.7341 -3.6757 -7.2583 29.0131
WT2-iPS GDSC1 -6.5537 -1.5438 -6.8763 49.0943
HMV-II GDSC1 -6.4941 -0.8794 -8.2442 32.7279
A-375 GDSC1 -6.4731 -4.709 -6.4743 48.2844
UACC-62 GDSC1 -5.8963 -3.2458 -6.5574 19.8358
IPC-298 GDSC1 -5.8431 -1.0374 -7.5429 25.9973
A101D GDSC1 -5.6605 -3.5634 -6.176 15.895
IST-MEL1 GDSC1 -5.6454 -1.6294 -7.0695 22.1729
MMAc-SF GDSC1 -5.55 -2.1954 -6.7055 19.2493
WM278 GDSC1 -5.4022 -2.3927 -6.4701 16.882
Mel JuSo GDSC1 -5.3333 -2.7781 -6.2184 14.6955
DJM-1 GDSC1 -5.2813 -2.9737 -6.0747 13.3742
CHL-1 GDSC1 -5.2263 -4.1082 -5.4915 8.6946
Hs 938.T GDSC1 -5.1204 -2.0035 -6.4012 15.1677
SK-MEL-24 GDSC1 -4.9906 -3.65 -5.4725 7.4691
SK-MEL-30 GDSC1 -4.9707 -1.8201 -6.3591 14.2474
SK-MEL-5 GDSC1 -4.9685 -0.8576 -6.8369 17.7041
MZ-MEL-2 GDSC1 -4.9417 1.4309 -7.9564 24.3676
GAK GDSC1 -4.8493 0.114 -7.2198 19.7794
COLO 783 GDSC1 -4.8178 -1.263 -6.5049 14.7383
Mel Ho GDSC1 -4.7332 -3.2331 -5.4485 6.2517
SK-MEL-28 GDSC1 -4.683 2.5557 -8.3006 25.0781
MZ-MEL-7 GDSC1 -4.5706 -2.0883 -5.8861 9.1082
UACC-257 GDSC1 -4.519 -0.3586 -6.7083 15.1024
LB2518-MEL GDSC1 -4.4931 -0.6606 -6.5364 13.7748
451Lu GDSC1 -4.4725 0.1115 -6.9054 16.3044
MeWo GDSC1 -4.469 -1.139 -6.2781 11.7721
Hs 940.T GDSC1 -4.4246 0.5654 -7.0932 17.3839
LB373-MEL-D GDSC1 -4.3819 1.8089 -7.6798 20.7912
A-388 GDSC1 -4.1672 1.5258 -7.3668 18.2105
COLO 679 GDSC1 -4.0084 3.3372 -8.1439 21.9656
SK-MEL-31 GDSC1 -2.6757 3.452 -7.2216 12.8877
SH-4 GDSC1 -0.2368 3.1004 -5.7733 0.9866
VMRC-MELG GDSC1 -0.1385 2.3984 -5.492 0.2795
SK-MEL-1 GDSC1 0.1815 3.8107 -5.8682 1.0514
SK-MEL-3 GDSC1 0.1908 2.7297 -5.4898 0.2115
COLO 829 GDSC1 0.6434 5.9355 -6.4784 3.0139
EquiPSC Line K2 GDSC1 -5.2586 -1.4648 -6.7922 18.5835
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -5.9992 -4.2565 -6.2542 18.2045
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 -9.1576 -7.1635 -9.1705 55.8146
HT-1080 GDSC1 -7.8397 -6.925 -7.8401 39.4939
SK-UT-1 GDSC1 -7.6744 -6.4001 -7.681 37.4655
SW982 GDSC1 -7.6408 -6.297 -7.6504 37.0632
Hs 633.T GDSC1 -7.5145 -6.4105 -7.5181 35.4487
STS-0421 GDSC1 -7.435 -5.4592 -7.5153 34.9129
MES-SA GDSC1 -7.2123 -4.6693 -7.4465 33.0589
KYM-1 GDSC1 -7.1761 -6.2445 -7.1785 31.2114
EW-8 GDSC1 -6.9423 -5.6452 -6.9673 28.4315
GCT GDSC1 -6.895 -3.4371 -7.5222 31.4992
Rh30 GDSC1 -6.0764 -0.7049 -7.9247 29.1503
Rh41 GDSC1 -6.041 -3.5253 -6.5859 20.7715
SK-LMS-1 GDSC1 -5.9411 -4.6885 -6.054 16.4998
SW872 GDSC1 -5.8953 -4.4851 -6.0643 16.3123
A-204 GDSC1 -5.8063 -2.3412 -6.8831 21.6808
RKN GDSC1 -5.1892 -4.2327 -5.3996 7.8329
VA-ES-BJ GDSC1 -5.0146 -1.0024 -6.8048 17.6648
MFH-ino GDSC1 -4.9761 -1.3217 -6.6121 16.1391
RD GDSC1 -4.8843 -2.6531 -5.8686 10.131
G-402 GDSC1 -4.7699 -0.9931 -6.5991 15.2453
SW684 GDSC1 -4.4895 0.5548 -7.1407 17.9246
Rh18 GDSC1 -0.2122 4.8373 -6.4321 3.7157
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS GDSC1 -11.1757 0.3002 -12.4158 76.7182
MKN28 GDSC1 -10.7813 1.6227 -12.4083 73.914
TMK-1 GDSC1 -8.8777 -6.3844 -8.8793 91.3714
SNU-16 GDSC1 -7.8633 -4.3512 -7.8985 80.6379
NUGC-3 GDSC1 -7.0235 -3.9194 -7.4794 32.0483
IM95 GDSC1 -7.0065 -4.2389 -7.3519 31.2092
23132/87 GDSC1 -6.8424 -5.0801 -6.944 27.6734
RERF-GC-1B GDSC1 -6.1914 -3.3028 -6.8367 23.2933
TGBC11TKB GDSC1 -5.6875 -2.5919 -6.6488 19.4804
MKN1 GDSC1 -5.5547 -2.5288 -6.5499 18.1521
SK-GT-2 GDSC1 -5.4697 -2.5563 -6.4553 17.0738
OCUM-1 GDSC1 -5.4017 -2.3762 -6.4777 16.9361
HSC-39 GDSC1 -5.3482 -4.345 -5.522 9.5369
Hs 746.T GDSC1 -5.101 -2.4886 -6.1439 13.1358
SCH GDSC1 -4.8821 -1.664 -6.3598 13.9049
SNU-5 GDSC1 -4.87 -3.4973 -5.4365 6.6878
NCI-N87 GDSC1 -4.6984 -1.7451 -6.1631 11.715
ECC10 GDSC1 -4.5829 -1.8595 -6.0104 10.1192
Fu97 GDSC1 -4.4924 -2.0746 -5.8301 8.4009
MKN45 GDSC1 -4.2147 1.0687 -7.1766 17.188
RF-48 GDSC1 -3.9294 2.7657 -7.7976 19.8993
MKN7 GDSC1 -3.7856 -0.337 -6.1591 8.7254
NUGC-4 GDSC1 -3.7212 7.0044 -9.744 27.5608
SNU-1 GDSC1 -0.1551 2.6814 -5.5944 0.4765
KATO III GDSC1 0.2078 2.5778 -5.4338 0.1442
SNG-M GDSC1 -9.5415 -6.888 -9.5838 59.9483
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 -7.9993 -6.8493 -8.0012 41.4973
CAL-62 GDSC1 -7.3515 -5.9881 -7.368 33.4915
KMH-2 GDSC1 -7.3308 -6.2013 -7.3367 33.1667
K5 GDSC1 -6.6414 -5.0628 -6.7295 25.0787
8305C GDSC1 -6.2601 -3.7959 -6.7066 22.767
HTC-C3 GDSC1 -5.9777 -4.4118 -6.1777 17.5531
B-CPAP GDSC1 -5.8908 -3.8952 -6.2756 17.7812
FTC-133 GDSC1 -5.5911 -3.0595 -6.335 16.7409
WRO GDSC1 -5.4314 -2.0945 -6.6424 18.2675
TT2609-C02 GDSC1 -4.6627 -1.8943 -6.0587 10.7788
BHT-101 GDSC1 -4.5924 -2.5576 -5.6694 7.4851
ASH-3 GDSC1 -4.2764 1.1294 -7.2558 17.9014
TT GDSC1 -0.9166 4.2722 -6.5457 5.2574
8505C GDSC1 -0.4183 3.5359 -6.0101 1.989
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 -9.4285 -8.3495 -9.4286 59.3439
JHU-029 GDSC1 -8.4833 -6.3412 -8.5219 47.6168
SAT [Human HNSCC] GDSC1 -7.7466 -5.2377 -7.8926 39.0804
PCI-04B GDSC1 -7.5329 -5.5409 -7.6077 36.0949
BICR 10 GDSC1 -7.3859 -5.9332 -7.4076 33.9534
Detroit 562 GDSC1 -7.3736 -5.2719 -7.4818 34.3142
KON GDSC1 -7.3544 -4.723 -7.5871 34.7758
KOSC-2 GDSC1 -7.2278 -5.7685 -7.2559 32.0177
HSC-3 GDSC1 -7.1987 -6.0152 -7.2086 31.5409
BB30-HNC GDSC1 -7.1755 -6.1024 -7.1814 31.2259
SKN-3 GDSC1 -7.1146 -3.8401 -7.6059 33.3109
CAL-27 GDSC1 -7.0512 -5.8191 -7.0673 29.7359
BICR 22 GDSC1 -7.0325 -5.9908 -7.039 29.4422
LB771-HNC GDSC1 -7.0305 -3.5159 -7.6361 32.9411
PCI-15A GDSC1 -6.999 -2.8572 -7.8667 33.8948
PE/CA-PJ15 GDSC1 -6.9753 -5.2508 -7.0554 29.1928
JHU-011 GDSC1 -6.9263 -5.4247 -6.9756 28.3862
HO-1-N-1 GDSC1 -6.8866 -5.1619 -6.9758 28.1455
NCI-H3118 GDSC1 -6.8411 -5.0963 -6.9393 27.6351
SCC-4 GDSC1 -6.831 -4.3444 -7.1271 28.774
BICR 78 GDSC1 -6.6868 -4.5524 -6.9063 26.5038
HSC-2 GDSC1 -6.5177 -4.9809 -6.6121 23.5749
OSC-19 GDSC1 -6.473 -4.7108 -6.6285 23.4228
BB49-HNC GDSC1 -6.1924 -4.3867 -6.4191 20.4112
Ca9-22 GDSC1 -5.8603 -4.6814 -5.9678 15.4541
PCI-06A GDSC1 -5.6411 -4.1001 -5.9293 13.9938
PCI-30 GDSC1 -5.4466 -1.7659 -6.8168 19.5684
UPCI-SCC-090 GDSC1 -5.3952 0.4128 -7.8447 25.6356
HSC-4 GDSC1 -5.3609 -3.1151 -6.0834 13.7941
OSC-20 GDSC1 -5.2346 -2.4313 -6.2947 14.8453
HO-1-u-1 GDSC1 -5.1043 -0.0559 -7.3547 21.6357
SCC-25 GDSC1 -4.9001 -1.5256 -6.4444 14.6077
SCC-15 GDSC1 -4.8315 -2.8736 -5.7126 8.7031
JHU-022 GDSC1 -4.7074 -0.5601 -6.7631 16.1809
SCC-9 GDSC1 -4.575 -2.5154 -5.6764 7.4795
BHY GDSC1 -4.4392 -2.3419 -5.6552 6.856
SAS GDSC1 -3.7197 6.8103 -9.6461 27.2306
CAL-33 GDSC1 -3.5687 -2.5611 -3.5703 24.0907
FaDu GDSC1 -0.7817 347.0641 -174.6355 49.3848
DOK GDSC1 0.042 4.3169 -6.113 2.0223
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 -7.3128 -6.3181 -7.3155 32.9224
RT-4 GDSC1 -7.0034 -4.8467 -7.1721 30.0998
UM-UC-3 GDSC1 -6.6443 -4.5669 -6.8557 25.9235
SW1710 GDSC1 -6.2727 -3.9608 -6.6566 22.4915
CAL-29 GDSC1 -5.8903 -3.2834 -6.5347 19.6434
639V GDSC1 -5.8901 -3.1123 -6.6107 20.1849
5637 GDSC1 -5.7095 -4.6026 -5.8257 13.6323
BFTC-905 GDSC1 -5.5651 -4.081 -5.8566 13.0751
T24 GDSC1 -5.5538 -4.4456 -5.7066 11.9449
KU-19-19 GDSC1 -5.2481 -4.2623 -5.4488 8.4905
SW780 GDSC1 -5.0736 -3.8127 -5.4737 7.8429
TCCSUP GDSC1 -4.9386 -1.6626 -6.4095 14.4989
J82 GDSC1 -4.7442 -1.9071 -6.1206 11.5571
647V GDSC1 -4.7175 -1.769 -6.1671 11.8162
HT-1197 GDSC1 -3.9306 3.7484 -8.2873 22.4107
HT-1376 GDSC1 -3.87 4.4236 -8.5759 23.5471
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Ca Ski GDSC1 -8.394 -6.0705 -8.4553 46.5816
CAL-39 GDSC1 -8.1757 -6.166 -8.2149 43.856
OVMIU GDSC1 -7.9242 -4.4572 -8.2839 41.9786
PWR-1E GDSC1 -7.7342 -5.9642 -7.7698 38.376
SW954 GDSC1 -7.6504 -6.5255 -7.6535 37.1446
JAR GDSC1 -7.5356 -6.6224 -7.5364 35.6953
SiSo GDSC1 -7.4379 -6.5193 -7.4391 34.4765
KGN GDSC1 -7.4171 -4.4212 -7.7417 36.0031
PEO1 GDSC1 -7.2515 -5.5961 -7.2996 32.4375
MS751 GDSC1 -7.234 -6.0377 -7.2439 31.9824
JEG-3 GDSC1 -7.0484 -6.1253 -7.0514 29.619
NEC8 GDSC1 -6.9811 -3.6145 -7.5457 32.1524
SW962 GDSC1 -6.8607 -4.6219 -7.0761 28.6294
C-33 A GDSC1 -6.6621 -4.5858 -6.8696 26.1189
HEY GDSC1 -6.3679 -3.7148 -6.8529 24.3469
C-4-I GDSC1 -6.2693 -4.3914 -6.5011 21.4026
ME-180 GDSC1 -6.2582 -4.0389 -6.6119 22.1043
HeLa GDSC1 -5.9267 -4.8427 -5.9999 16.0539
TC-YIK GDSC1 -5.8861 -3.6729 -6.3622 18.3804
BPH-1 GDSC1 -5.5762 -3.9577 -5.919 13.5865
SKN GDSC1 -5.4961 -2.7429 -6.3914 16.7202
OVCA433 GDSC1 -5.4114 -2.8149 -6.2753 15.4716
DoTc2 4510 GDSC1 -5.273 33.5049 -21.7352 50.8391
ACC-OV7 GDSC1 -4.865 -2.8056 -5.7757 9.3285
HT-3 GDSC1 -4.8389 -1.7303 -6.2896 13.2079
OVCA420 GDSC1 -4.7863 -2.1389 -6.0404 11.0947
UWB1.289 GDSC1 -4.6717 -0.2383 -6.8942 16.9558
LB831-BLC GDSC1 -4.5582 -1.7454 -6.0474 10.3184
DSH1 GDSC1 -4.4132 -0.508 -6.5483 13.581
SKG-IIIa GDSC1 -4.3382 -0.2319 -6.6263 13.8843
NT2-D1 GDSC1 -4.332 5.6519 -9.5592 28.8407
SW756 GDSC1 -4.3295 -1.0624 -6.2059 10.7512
SiHa GDSC1 -3.9902 4.9586 -8.9374 25.4601
OV17R GDSC1 -3.358 1.2614 -6.6344 10.9196
HEC-1 GDSC1 -2.7749 4.286 -7.692 15.8736
OMC-1 [Human cervical carcinoma] GDSC1 -2.1308 4.7663 -7.4854 13.0747
JHOS-3 GDSC1 -0.267 3.8248 -6.0563 2.0509
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7708).
2 Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
3 Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem. 2011 Oct 13;54(19):6734-50. doi: 10.1021/jm200629m. Epub 2011 Sep 7.