Details of the Drug

General Information of Drug (ID: DMFZXI2)

Drug Name
NVP-TAE684
Synonyms
761439-42-3; NVP-TAE684; NVP-TAE 684; TAE684; TAE-684; 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine; TAE684 (NVP-TAE684); TAE 684; UNII-EH1713MN4K; CHEMBL509032; EH1713MN4K; 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; C30H40ClN7O3S
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 614.2
Logarithm of the Partition Coefficient (xlogp) 5.7
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C30H40ClN7O3S
IUPAC Name
5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
Canonical SMILES
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
InChI
InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
InChIKey
QQWUGDVOUVUTOY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
16038120
ChEBI ID
CHEBI:91338
CAS Number
761439-42-3
TTD ID
D0R2WK
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Drug Response [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [3]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Post-Translational Modifications [4]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Drug Response [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Drug Response [4]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Drug Response [4]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Drug Response [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lymphoma
ICD Disease Classification 2A80-2A86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Insulin receptor (INSR) DTT INSR 1.03E-05 0.26 0.66
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 212 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -0.3316 2.7786 -0.3937 38.5735
MEC1 CTRP2 1.9008 3.5273 1.8953 27.6238
JM1 GDSC1; CTRP2 -0.4518 2.5251 -0.474 43.336
SR GDSC1; CTRP2 -7.4927 -4.5612 -7.4928 87.6416
SUP-M2 GDSC1; CTRP2; CCLE -6.3972 -5.8908 -6.3972 82.8877
DEL GDSC1; CTRP2; CCLE -6.3014 -4.3233 -6.3014 81.9462
SCC-3 GDSC1 -6.2177 24.8986 -17.3925 55.6192
Ki-JK CTRP2 -6.2019 -5.3771 -6.2019 81.5847
SU-DHL-1 GDSC1; CTRP2 -5.5369 -4.7833 -5.5369 77.1559
Karpas-299 GDSC1; CTRP2; CCLE -4.9064 2.8513 -5.2105 67.5189
EoL-1 GDSC1; CTRP2 -4.159 -0.9304 -4.1618 67.6212
A4/Fukuda GDSC1; CTRP2 -4.0836 -0.4506 -4.0908 66.9376
KHM-1B CTRP2; CCLE -3.4376 -1.4764 -3.4376 63.1584
MM1.S CTRP2 -3.3365 -0.128 -3.3412 62.3088
NCI-H929 CTRP2 -3.3343 -1.2622 -3.3344 62.4665
ATN-1 GDSC1 -2.4592 2.2595 -3.181 45.0693
OPM-2 GDSC1; CTRP2; CCLE -2.2079 -0.9152 -2.2079 54.9779
KMS-11 CTRP2; CCLE -2.1117 2.7278 -2.2177 54.0552
SEM CTRP2 -2.0966 -0.4912 -2.0967 54.2365
ALL-PO GDSC1 -1.9838 0.2556 -2.0874 37.8691
KMS-34 CTRP2; CCLE -1.972 0.1878 -1.9726 53.4029
KMS-20 CTRP2 -1.8434 1.8027 -1.8717 52.4942
KMS-21-BM CTRP2 -1.575 0.2939 -1.5752 50.761
PL21 CTRP2 -1.5177 2.6952 -1.5906 50.3648
ML-2 GDSC1 -1.4937 1.5326 -1.8835 33.4661
Mono-Mac-1 CTRP2; CCLE -1.2827 3.1548 -1.3873 48.8706
MOLM-13 GDSC1; CTRP2 -1.2474 2.0561 -1.2708 48.5984
NB4 GDSC1; CTRP2 -1.2464 1.0604 -1.2484 48.5743
MOLP-8 GDSC1; CTRP2; CCLE -1.2351 3.6263 -1.3941 48.5949
GDM-1 GDSC1 -1.225 3.7519 -2.4911 34.688
AML-193 CTRP2 -1.2152 3.1022 -1.3106 48.435
KMS-28BM CTRP2 -1.212 3.3426 -1.3335 48.43
KMS-27 CTRP2 -1.2118 1.7237 -1.2234 48.3538
KMS-26 CTRP2; CCLE -1.1334 0.2665 -1.1334 47.8195
ALL-SIL GDSC1; CCLE -1.0688 0.7369 -1.0803 34.9927
RPMI-8226 GDSC1; CTRP2 -1.0334 3.2331 -1.1323 47.2711
CTV-1 GDSC1 -1.0064 1.7731 -1.4405 27.8867
PL-21 GDSC1 -0.9567 4.3075 -2.4739 33.1063
L-540 GDSC1; CTRP2 -0.8858 4.3964 -1.1409 46.4959
KMS-18 CTRP2 -0.8816 1.6917 -0.8879 46.1552
NALM-6 GDSC1; CTRP2 -0.785 1.8641 -0.7933 45.517
OCI-AML-2 GDSC1; CTRP2; CCLE -0.7486 0.9404 -0.7488 45.2563
CMK-86 CCLE -0.7332 2.6962 -0.9954 33.1504
MV4-11 GDSC1; CTRP2 -0.6985 1.8064 -0.7047 44.9373
Kasumi-1 GDSC1; CTRP2 -0.6853 3.1619 -0.7587 44.9788
L-363 GDSC1; CTRP2; CCLE -0.6805 2.7326 -0.7209 44.8876
TALL-1 [Human adult T-ALL] CTRP2 -0.6785 2.9735 -0.7357 44.9057
KG-1 GDSC1; CCLE -0.6484 1.9477 -0.7515 31.774
Peer CTRP2 -0.6352 0.6521 -0.6352 44.5003
SIG-M5 GDSC1; CTRP2; CCLE -0.6078 1.1105 -0.6081 44.319
OCI-AML-5 GDSC1; CTRP2; CCLE -0.4488 1.7314 -0.4516 43.2666
P32/ISH GDSC1 -0.4283 0.2997 -0.4371 17.9086
MOLT-4 GDSC1 -0.3452 1.1587 -0.5143 17.9366
KMS-12-BM GDSC1; CTRP2; CCLE -0.3434 3.9011 -0.48 42.8718
RS4;11 GDSC1; CTRP2 -0.3402 4.8754 -0.6425 43.1617
KE-37 GDSC1; CTRP2 -0.3054 0.6733 -0.3054 42.3034
MOLM-16 CTRP2 -0.2694 3.5325 -0.3572 42.2843
BE-13 GDSC1 -0.2665 1.1387 -0.4223 16.864
JJN-3 GDSC1; CTRP2 -0.1565 2.0131 -0.1602 41.3225
Karpas-45 GDSC1 -0.1517 1.6265 -0.47 16.5783
HPB-ALL CTRP2 -0.0821 1.9963 -0.085 40.8245
MOLM-6 CTRP2 -0.0494 2.9403 -0.0799 40.687
Karpas-231 GDSC1 -0.0418 1.1125 -0.1696 13.8695
SKM-1 GDSC1; CTRP2 -0.0378 0.9121 -0.0378 40.5203
697 GDSC1; CTRP2; CCLE -0.0377 1.8434 -0.0391 40.524
AMO1 GDSC1; CTRP2; CCLE -0.0116 3.5071 -0.083 40.5467
LP-1 GDSC1; CTRP2; CCLE 0.0075 4.3209 -0.1659 40.6745
BV-173 GDSC1; CTRP2 0.0106 3.3362 -0.0446 40.3566
NCO2 CTRP2; CCLE 0.0311 2.0856 0.0281 40.0712
HL-60 GDSC1; CTRP2 0.0761 3.3911 0.0195 39.927
GR-ST GDSC1 0.1198 8.1092 -3.3124 31.3377
JeKo-1 CTRP2 0.1402 2.5307 0.1306 39.365
SET-2 CTRP2 0.1663 3.7549 0.0793 39.4136
JURL-MK1 GDSC1; CTRP2 0.178 2.3987 0.1719 39.1021
PF-382 GDSC1; CTRP2 0.2802 2.488 0.2737 38.4227
NK-92MI GDSC1 0.288 2.8008 -0.5457 15.0155
MHH-CALL-4 CTRP2 0.2966 7.4262 -0.6536 40.4783
Ri-1 CTRP2 0.3277 3.4159 0.2803 38.2321
SU-DHL-16 GDSC1 0.3663 1.007 0.3065 8.314
Daudi GDSC1; CTRP2 0.3782 3.1413 0.3508 37.8358
CESS GDSC1 0.3887 1.9904 -0.0654 10.9142
HEL GDSC1 0.3995 3.4317 -0.7465 16.0341
MOLT-3 CTRP2 0.4134 1.7355 0.4133 37.5148
P12-Ichikawa CTRP2; CCLE 0.4193 1.6152 0.4193 37.4753
Mono-Mac-6 GDSC1; CTRP2 0.4239 12.1636 -2.4066 42.4431
OCI-AML-3 GDSC1; CTRP2 0.4507 1.76 0.4506 37.2666
MOLP-2 CTRP2 0.4872 9.853 -1.3617 40.9099
EM-2 GDSC1; CTRP2; CCLE 0.5123 1.7981 0.5122 36.8561
MOLT-16 GDSC1; CTRP2; CCLE 0.5382 1.9609 0.538 36.6839
NKM-1 GDSC1 0.5414 5.0553 -1.4215 20.1806
KOPN-8 GDSC1 0.6268 1.8972 0.212 7.7125
H9 GDSC1 0.6421 8.7037 -3.154 28.6965
F-36P CTRP2; CCLE 0.6571 3.6511 0.6057 36.056
QIMR-WIL GDSC1 0.6595 2.153 0.1199 8.2812
Ku812 GDSC1; CTRP2; CCLE 0.6669 2.0561 0.6667 35.8263
U266B1 GDSC1; CTRP2 0.7282 4.0392 0.6422 35.6918
CCRF-CEM GDSC1 0.7479 3.0132 -0.2237 10.5969
NOMO-1 GDSC1; CTRP2 0.7593 4.7797 0.5662 35.8103
Pfeiffer CTRP2; CCLE 0.7631 2.9999 0.7518 35.222
KYO-1 CTRP2 0.7781 2.621 0.775 35.0951
Karpas-422 GDSC1; CTRP2; CCLE 0.7852 2.3908 0.7841 35.0412
RPMI-8402 GDSC1; CTRP2; CCLE 0.7995 3.4363 0.7695 35.0406
JSC-1 GDSC1 0.831 3.2412 -0.2644 10.5905
Mino CTRP2; CCLE 0.8482 2.4299 0.8471 34.6213
GA-10 GDSC1; CTRP2 0.8568 2.4027 0.8559 34.5633
SU-DHL-6 GDSC1; CTRP2; CCLE 0.8958 3.3362 0.8745 34.3709
LAMA-84 GDSC1; CTRP2 0.9067 3.1684 0.8928 34.2743
HAL-01 GDSC1 0.9447 7.7266 -2.4095 24.2558
CML-T1 CTRP2 0.9761 2.7867 0.9726 33.7776
Loucy GDSC1 0.9879 1.974 0.5028 3.965
OCI-Ly19 GDSC1; CTRP2 1.0362 4.9237 0.839 33.9993
M-07e CTRP2 1.0519 4.0584 0.9825 33.489
Namalwa GDSC1; CTRP2 1.0769 4.3074 0.9799 33.4118
A3/Kawakami GDSC1; CTRP2 1.0937 2.8149 1.0909 32.9915
Jurkat CTRP2; CCLE 1.099 3.6019 1.0697 33.0441
ARH-77 GDSC1 1.1335 9.0599 -2.9192 25.9306
NU-DUL-1 GDSC1; CTRP2 1.1645 2.5536 1.1639 32.5127
Granta-519 GDSC1; CTRP2; CCLE 1.1658 4.2687 1.0793 32.7871
DND-41 GDSC1; CTRP2 1.1838 3.5363 1.1611 32.4574
SK-MM-2 GDSC1; CTRP2; CCLE 1.2011 5.7201 0.8437 33.4116
SUP-HD1 GDSC1; CTRP2 1.2219 4.1795 1.1491 32.3692
Ci-1 CCLE 1.2556 4.2967 0.6339 17.9389
Farage GDSC1 1.2628 2.6318 0.3914 3.9279
KY821 GDSC1 1.2815 2.3866 0.525 2.8415
HC-1 GDSC1 1.3015 5.3273 -0.9178 13.8223
JVM-3 GDSC1; CTRP2; CCLE 1.331 3.3284 1.3208 31.4353
Karpas-620 GDSC1; CTRP2; CCLE 1.335 6.6536 0.7265 33.3016
KM-H2 GDSC1; CTRP2 1.3381 4.1883 1.271 31.5773
HuT 78 CTRP2; CCLE 1.3494 4.0455 1.2971 31.4529
P31/FUJ GDSC1; CCLE 1.3604 2.6349 1.2954 14.3681
SU-DHL-8 GDSC1; CTRP2; CCLE 1.3712 3.6088 1.3174 26.4121
SU-DHL-10 CTRP2; CCLE 1.4178 3.0967 1.4047 25.9324
EJM GDSC1; CTRP2 1.4322 4.91 1.2691 31.2695
Ramos.2G6.4C10 GDSC1 1.4441 5.0846 -0.685 11.6391
Hs 611.T CTRP2 1.4663 3.4616 1.4546 30.5391
KMOE-2 GDSC1 1.4736 6.8504 -1.5405 17.4412
BALL-1 GDSC1 1.4948 3.5612 0.1047 5.4568
SUP-B15 GDSC1; CTRP2 1.5027 3.8078 1.4754 30.3483
CTB-1 GDSC1 1.5215 3.733 0.04 5.8762
Kasumi-2 CTRP2; CCLE 1.546 3.6286 1.5296 30.0238
KCL-22 GDSC1; CTRP2; CCLE 1.5477 3.9011 1.5159 30.0639
K-562 GDSC1; CTRP2 1.5721 2.9692 1.571 29.7987
MOTN-1 CTRP2 1.5855 3.8019 1.5615 29.7858
BC-3 GDSC1 1.5898 5.2531 -0.6572 10.963
RPMI-8866 GDSC1 1.6221 4.1472 -0.0901 6.5813
CMK CTRP2 1.6246 3.892 1.5965 29.5392
KO52 CTRP2; CCLE 1.6371 4.5175 1.5492 29.6569
DoHH2 GDSC1; CCLE 1.6612 11.6121 -2.467 29.3276
KE-97 CTRP2; CCLE 1.6881 3.705 1.6722 29.0754
WIL2 NS GDSC1 1.7001 3.4243 0.3099 3.3681
Reh GDSC1; CCLE 1.7112 3.2567 1.5158 11.9656
MEC-1 CCLE 1.7171 4.9355 0.8295 15.3877
SU-DHL-4 GDSC1; CTRP2; CCLE 1.7488 4.9412 1.4755 24.5373
MC116 GDSC1; CTRP2; CCLE 1.7681 3.2668 1.757 23.4249
MHH-PREB-1 GDSC1 1.7746 4.1104 0.0334 5.2291
CA46 GDSC1; CTRP2 1.8575 3.973 1.833 27.9758
BC-1 GDSC1 1.9045 3.9049 0.2143 3.5845
MLMA GDSC1 1.9125 6.2302 -0.8991 11.7173
VL51 GDSC1 1.969 6.2409 -0.8633 11.2963
OCI-M1 GDSC1; CTRP2 1.9976 3.5307 1.9934 26.9743
ME1 GDSC1 1.9998 7.8259 -1.6198 16.2167
DB GDSC1; CTRP2 2.0553 3.5386 2.0517 26.5879
HT GDSC1; CTRP2; CCLE 2.0928 3.7062 2.086 26.3489
BL-70 CTRP2; CCLE 2.1149 3.1652 2.1146 26.1798
RCH-ACV CTRP2 2.1356 4.514 2.0786 26.2333
OCI-Ly10 CTRP2; CCLE 2.1405 4.9513 2.0249 26.4006
MN-60 GDSC1 2.1575 5.6994 -0.4691 7.9359
ST486 GDSC1 2.1577 7.5027 -1.3443 13.9979
HD-MY-Z CTRP2; CCLE 2.1704 3.7915 2.1627 25.8349
VAL GDSC1 2.1713 7.3638 -1.2664 13.4494
MHH-CALL-3 CTRP2 2.2331 6.2334 1.8319 26.7752
HH [Human lymphoma] GDSC1; CTRP2; CCLE 2.2456 4.2134 2.2202 25.3935
Hs 445 GDSC1 2.2748 4.967 -0.0486 4.6261
NU-DHL-1 CTRP2 2.3239 3.5129 2.3228 24.7901
MJ CCLE 2.3406 3.9564 1.9019 7.8239
SUP-T1 GDSC1; CTRP2; CCLE 2.3613 6.0634 2.0197 25.7193
JVM-2 GDSC1 2.3653 9.6821 -2.2624 18.7603
L-428 GDSC1; CTRP2; CCLE 2.3989 4.5654 2.3512 24.4474
LC4-1 GDSC1 2.4078 5.5415 -0.2323 5.6226
EHEB GDSC1; CTRP2 2.5122 4.1893 2.4974 23.5818
SUP-T11 CTRP2 2.5257 5.1151 2.4123 23.8286
THP-1 GDSC1; CTRP2 2.5341 4.2413 2.5173 23.4425
Jiyoye GDSC1 2.5492 5.1593 0.0255 3.5605
RL GDSC1; CTRP2 2.5565 4.1344 2.5454 23.2741
WSU-DLCL2 GDSC1; CTRP2 2.6013 3.8689 2.5984 22.9481
EB1 CTRP2; CCLE 2.6826 4.136 2.6745 22.4237
TF-1 CTRP2 2.6966 4.2979 2.682 22.3524
RPMI-6666 GDSC1; CTRP2 2.7485 5.1643 2.6439 22.3142
HDLM-2 GDSC1; CTRP2 2.8468 5.0197 2.7717 21.5577
HEL 92.1.7 CTRP2; CCLE 2.8637 4.7373 2.8237 21.3251
DG-75 GDSC1 3.1171 5.2778 0.2629 1.3502
U-698-M GDSC1 3.1267 9.6662 -1.7145 13.6025
MY-M12 GDSC1 3.1603 5.0349 0.3753 0.8159
OCI-Ly3 CTRP2 3.1703 5.4295 3.0518 19.5536
L-1236 GDSC1; CTRP2 3.1941 5.215 3.1146 19.2595
YT GDSC1 3.2104 4.6268 0.5428 0.2571
U-937 CTRP2; CCLE 3.2332 5.8146 3.036 19.4127
Toledo CTRP2; CCLE 3.5837 4.7403 3.574 16.4261
BDCM CCLE 3.8447 5.8674 2.1943 2.6571
P3HR-1 CTRP2; CCLE 3.9102 7.3357 2.8561 12.4786
KMM-1 CTRP2; CCLE 4.3201 11.0924 1.9707 20.4962
MEG-01 GDSC1; CCLE 4.5296 9.2733 1.0284 7.382
ME1 CTRP2 4.6138 11.0867 2.2504 18.7475
ROS-50 GDSC1 4.7986 12.7125 -2.0748 11.7852
IM-9 GDSC1 4.8376 15.0228 -3.1291 16.6659
P30/OHK GDSC1 5.0356 17.4001 -4.1295 20.1295
TUR GDSC1 5.0692 15.8842 -3.3854 17.2447
EB2 GDSC1; CCLE 5.1899 6.9784 2.4086 0.4589
WSU-NHL GDSC1 5.2057 16.9621 -3.8069 18.6051
BL-41 GDSC1; CTRP2; CCLE 5.2435 14.0988 1.3318 20.632
Raji GDSC1; CCLE 5.4707 6.7657 2.587 0.0759
JM-1 CCLE 5.9484 7.4486 2.5222 0.0776
⏷ Show the Full List of 212 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -0.0672 5.1218 -0.398 41.4977
TE8 CTRP2 0.4179 3.9132 0.3279 37.7596
TE-8 GDSC1 -1.033 1.3623 -1.3272 27.318
TE-11 GDSC1; CTRP2; CCLE 0.4951 3.7928 0.4225 37.1965
TE-6 GDSC1; CTRP2 0.8151 3.6201 0.7733 34.9747
TE-4 CTRP2 0.8268 6.4996 0.2198 36.5177
OE21 CTRP2; CCLE 1.139 2.7708 1.137 32.6871
TE-9 GDSC1; CTRP2; CCLE 1.1821 3.5117 1.1607 32.4645
KYSE-410 CTRP2; CCLE 1.5484 4.0721 1.5035 30.1034
TE-1 GDSC1; CTRP2; CCLE 1.7309 4.0962 1.6924 28.8662
KYSE-30 CTRP2; CCLE 1.8078 3.354 1.8044 28.2363
KYSE-70 CTRP2; CCLE 1.8224 4.1054 1.7873 28.2453
TE-5 GDSC1; CTRP2; CCLE 1.8224 2.8111 1.8223 28.1278
TE-10 GDSC1; CTRP2 1.8278 4.5335 1.6592 23.58
OE19 CTRP2 1.8958 2.7173 1.8958 27.6388
KYSE-140 CTRP2; CCLE 1.8992 3.6708 1.8898 27.647
EC-GI-10 GDSC1; CTRP2 1.9075 3.0526 1.9071 27.562
OE33 CTRP2; CCLE 1.9713 3.4548 1.9681 27.1461
TE-14 CTRP2 2.112 3.1727 2.1117 26.1993
KYSE-520 CTRP2; CCLE 2.1211 4.1919 2.0922 26.2345
COLO 680N CTRP2 2.1536 4.7803 2.0647 26.2221
KYSE-180 CTRP2; CCLE 2.1926 4.0392 2.1756 25.7183
KYSE-150 CTRP2; CCLE 2.1977 4.0445 2.1806 25.6844
KYSE-510 CTRP2; CCLE 2.2967 3.6049 2.2945 24.9751
TE-15 GDSC1; CCLE 3.0066 5.4593 1.7758 6.6165
KYSE-450 CTRP2; CCLE 3.3725 5.0422 3.3287 17.9486
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 1.407 2.9864 1.4047 30.9026
MZ-PC-1 GDSC1 -2.4873 3.3931 -3.6488 45.9471
PaTu 8988s CTRP2 -1.3647 2.8953 -1.4478 49.3869
Panc 08.13 CTRP2 -0.7624 2.5666 -0.7959 45.4153
Capan-1 CTRP2 -0.4524 9.9486 -2.3936 45.5761
Capan-2 CTRP2; CCLE -0.0778 2.5799 -0.093 40.8324
HuP-T4 CTRP2; CCLE -0.0127 3.9102 -0.1289 40.6677
MIA PaCa-2 CTRP2; CCLE 0.3184 3.0919 0.2916 38.232
AsPC-1 CTRP2; CCLE 0.4017 4.4615 0.2351 38.0827
TCC-Pan2 CTRP2 0.4033 4.0274 0.2987 37.8983
KCI-MOH1 CCLE 0.6482 2.889 0.4629 21.0287
HPAC CTRP2; CCLE 0.674 2.5273 0.6711 35.7882
SW1990 CTRP2; CCLE 0.7341 3.9586 0.6575 35.6233
PK-59 CTRP2; CCLE 0.7413 2.9525 0.731 35.3642
SNU-213 CTRP2 0.7999 4.6447 0.6334 35.4637
KP-2 CTRP2; CCLE 1.1486 3.6628 1.1173 32.7205
BxPC-3 CTRP2; CCLE 1.1623 3.6175 1.1343 32.6183
QGP-1 CTRP2; CCLE 1.3496 5.2094 1.1223 32.0259
KP-3 CTRP2; CCLE 1.3566 4.9291 1.1841 31.8015
PK-45H CTRP2; CCLE 1.4804 3.4293 1.4701 30.4404
PaTu 8902 CTRP2; CCLE 1.6676 3.7285 1.6501 29.2171
PL45 CCLE 1.7111 3.3919 1.4697 12.1875
Hs 766T CTRP2; CCLE 1.7123 4.5509 1.6249 29.155
YAPC CTRP2 1.7178 5.3615 1.4901 29.5913
DAN-G CTRP2 1.7638 3.9908 1.7345 28.6162
Panc 10.05 CTRP2; CCLE 1.777 3.799 1.7594 28.4889
Panc 05.04 CTRP2 1.8932 4.9888 1.7524 28.1325
KP-1N CCLE 2.0163 4.8477 1.1676 12.6794
Panc 03.27 CTRP2; CCLE 2.0853 3.7741 2.0764 26.406
KP-4 CTRP2; CCLE 2.1377 4.1079 2.115 26.1032
Panc 04.03 CTRP2; CCLE 2.2068 4.8272 2.1149 25.8781
PaTu 8988t CTRP2 2.4327 2.886 2.4327 24.0615
Panc 02.03 CTRP2; CCLE 2.4929 3.4815 2.4926 23.6617
KP-1NL CCLE 2.5068 5.7842 1.1782 11.1644
HuP-T3 CTRP2; CCLE 2.5153 4.8589 2.44 23.7664
CFPAC-1 CTRP2 2.5227 4.0848 2.5127 23.4957
L3.3 CTRP2; CCLE 2.6019 4.1266 2.5922 22.967
PSN1 GDSC1; CTRP2; CCLE 2.7292 4.8332 2.671 22.283
SNU-410 CTRP2 2.9654 6.1889 2.6436 21.6403
PK-1 CCLE 2.9738 5.7341 1.6111 7.5904
HPAF-II CTRP2; CCLE 2.9938 5.3905 2.8682 20.754
SU.86.86 CTRP2; CCLE 3.1913 5.3284 3.0929 19.3439
SUIT-2 CTRP2; CCLE 3.8945 7.2902 3.2703 16.6081
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 0.2511 7.0312 -0.5727 40.5108
Hs 688(A).T CTRP2 -0.4917 4.9436 -0.8211 44.1506
Hs 852.T CTRP2; CCLE -0.3173 3.3134 -0.3861 42.5556
SH-4 GDSC1 0.3377 5.4977 -1.8221 23.5151
LB2518-MEL GDSC1 0.8619 2.6964 0.0342 8.1316
Hs 940.T CTRP2 0.9474 3.3504 0.9269 34.0245
A-388 GDSC1 1.0057 3.4188 -0.2047 9.471
COLO 800 GDSC1; CTRP2 1.0214 4.6997 0.8626 33.977
LOX-IMVI GDSC1; CTRP2; CCLE 1.1686 2.6471 1.1676 32.4867
Hs 895.T CTRP2; CCLE 1.1733 4.6968 1.0265 32.9329
A-375 CTRP2; CCLE 1.2343 4.0492 1.1757 32.24
WM983B CTRP2; CCLE 1.2516 5.4399 0.9656 32.8591
SK-MEL-24 CTRP2; CCLE 1.4535 4.1358 1.3979 30.771
UACC-257 GDSC1; CTRP2; CCLE 1.5151 3.0645 1.5128 30.1825
CHL-1 CCLE 1.5176 3.9925 1.0339 15.0283
MDA-MB-435S CTRP2; CCLE 1.5326 5.1118 1.3403 30.7004
Malme-3M CCLE 1.5608 7.5575 -0.5665 22.6812
CJM [Human melanoma] CTRP2 1.591 2.1733 1.591 29.6692
SF8657 CCLE 1.646 2.462 1.6271 11.7104
RPMI-7951 CTRP2; CCLE 1.6776 3.3398 1.6729 29.108
DJM-1 GDSC1 1.7341 6.2223 -1.0275 13.1683
Hs 934.T CTRP2 1.7621 3.3103 1.7589 28.5399
G-361 CCLE 1.8786 2.7481 1.8346 9.8253
CP66-MEL GDSC1 1.8835 3.6503 0.3187 2.8908
Hs 839.T CTRP2 1.935 5.0789 1.7816 27.8971
CP67-MEL GDSC1 2.02 6.172 -0.7931 10.6491
MMAc-SF GDSC1 2.0831 7.7635 -1.527 15.3855
K029AX CTRP2; CCLE 2.1291 4.2526 2.096 26.1953
HMCB CTRP2; CCLE 2.2193 3.5763 2.2168 25.4916
MeWo CTRP2; CCLE 2.2303 4.7154 2.1553 25.6636
GAK GDSC1 2.2588 3.5932 0.542 0.8996
Mel Ho CTRP2; CCLE 2.2705 3.1562 2.2704 25.1427
SK-MEL-3 CTRP2 2.2772 4.5851 2.2206 25.2884
LB373-MEL-D GDSC1 2.2875 6.9404 -0.9777 11.1782
MZ-MEL-2 GDSC1 2.3193 6.8812 -0.9269 10.7414
A101D GDSC1; CTRP2 2.3476 3.8508 2.3415 24.6489
WM115 CTRP2; CCLE 2.39 2.8899 2.39 24.3463
IGR-1 CTRP2 2.4506 3.1837 2.4506 23.9422
Hs 294T CTRP2; CCLE 2.4514 5.2462 2.3087 24.4246
IGR-39 CTRP2; CCLE 2.4537 3.7635 2.4508 23.9312
WM266-4 CTRP2; CCLE 2.456 3.0181 2.456 23.9065
COLO 829 GDSC1; CTRP2 2.4843 13.3046 -0.8563 33.6375
Hs 944.T CCLE 2.5106 5.5176 1.3133 10.4314
COLO 792 CTRP2 2.5321 3.7834 2.5297 23.4076
A2058 CTRP2; CCLE 2.5445 3.4895 2.5443 23.3175
SK-MEL-5 CTRP2; CCLE 2.6363 3.2901 2.6363 22.7052
RVH-421 CTRP2; CCLE 2.6532 3.8451 2.6511 22.5996
Mel JuSo CTRP2 2.6932 4.6165 2.6559 22.4519
WM793 CTRP2; CCLE 2.77 4.2808 2.7583 21.8534
SK-MEL-1 GDSC1; CTRP2 2.7796 4.6115 2.747 21.8604
UACC-62 CTRP2; CCLE 2.8249 4.6822 2.7882 21.5723
HT-144 GDSC1; CTRP2; CCLE 2.8383 5.4242 2.6932 21.8575
IGR-37 CTRP2; CCLE 2.9826 4.1827 2.9786 20.4112
COLO 679 CCLE 3.0003 5.3013 1.8496 6.2324
WM1799 CTRP2; CCLE 3.0836 4.1963 3.0807 19.7348
Hs 695T CCLE 3.1142 7.669 0.76 11.7955
COLO 741 CCLE 3.1243 8.8678 0.169 14.7858
IPC-298 CTRP2; CCLE 3.2773 4.6484 3.2627 18.4838
Hs 936.T CTRP2; CCLE 3.3162 4.6749 3.3014 18.2254
MZ-MEL-7 GDSC1 3.3413 4.7546 0.5458 0.2083
SK-MEL-31 CTRP2; CCLE 3.4024 5.7036 3.2465 18.1402
SK-MEL-30 CTRP2; CCLE 3.4104 3.9338 3.4104 17.5482
Hs 938.T CCLE 3.5075 5.5059 2.1407 3.5351
WM88 CTRP2; CCLE 3.527 5.4962 3.425 17.1207
IST-MEL1 GDSC1 3.5565 12.2852 -2.6803 17.6033
SK-MEL-28 CTRP2 3.6128 4.0993 3.6128 16.1998
SK-MEL-2 GDSC1; CTRP2; CCLE 3.7276 4.5578 3.726 15.44
WT2-iPS CTRP2; CCLE 3.7747 6.7191 3.3551 16.6273
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 -0.7773 3.1112 -1.75 28.4732
HCE-4 GDSC1 0.0978 3.2383 -0.9379 18.7742
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 1.9908 4.9418 -0.2189 6.5404
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1; CTRP2 -9.658 -0.712 -9.8266 83.9737
NH-6 CTRP2 -2.8588 2.1236 -2.9465 58.6202
LA-N-6 GDSC1 -2.578 1.103 -2.9334 45.6194
NB(TU)1 GDSC1 -1.7149 0.778 -1.9053 35.0419
NB69 GDSC1 -1.6583 1.7303 -2.1288 35.7986
KP-N-RT-BM-1 GDSC1 -1.5716 2.9283 -2.495 36.815
CHP-212 CTRP2; CCLE -1.4419 2.0195 -1.4689 49.8768
SK-N-SH CTRP2; CCLE -1.3684 2.893 -1.4514 49.41
SJNB-14 GDSC1 -0.9724 6.701 -3.6244 37.1527
SK-N-BE(2)-M17 GDSC1 -0.7243 2.6717 -1.5034 26.7
SK-N-FI GDSC1; CTRP2; CCLE -0.4437 5.2813 -0.8435 43.9603
TGW GDSC1 -0.2923 3.548 -1.4638 24.2146
KP-N-SI9s CTRP2; CCLE -0.1882 2.0558 -0.1928 41.5364
MHH-NB-11 GDSC1; CTRP2 -0.0143 3.0938 -0.0528 40.4761
IMR-32 CCLE 0.0421 3.6058 -0.4117 27.4217
Kelly GDSC1; CTRP2; CCLE 0.2405 5.2505 -0.0917 39.5476
SK-N-BE(2) CTRP2; CCLE 0.2699 5.7383 -0.1766 39.6238
SJNB-13 GDSC1 0.3537 3.1501 -0.6518 15.5243
GI-ME-N GDSC1 0.3624 8.9287 -3.5075 31.0606
SJNB-10 GDSC1 0.4291 5.8251 -1.9034 23.5973
SJNB-5 GDSC1 0.4606 3.4275 -0.6881 15.3373
SK-N-AS CTRP2; CCLE 0.4714 4.2151 0.3466 37.5068
SK-N-DZ GDSC1; CTRP2; CCLE 0.5741 3.3171 0.5433 36.543
CHP-126 GDSC1; CTRP2 0.8086 4.1795 0.7106 35.1958
SJNB-7 GDSC1 0.8877 2.9648 -0.0774 8.9101
SJNB-6 GDSC1 1.0822 2.7915 0.1718 6.2398
SJNB-17 GDSC1 1.317 7.6074 -2.0434 20.9712
IMR-5 GDSC1 1.3472 4.3876 -0.4139 9.9137
NH-12 GDSC1 1.7313 4.527 -0.1974 7.0847
KP-N-YS GDSC1 1.8017 3.5886 0.2972 3.2234
SiMa GDSC1; CCLE 2.2027 4.9712 1.2907 11.4553
GOTO GDSC1 2.2479 8.8755 -1.9523 17.4184
KP-N-YN GDSC1; CTRP2 3.6769 9.5835 2.0539 21.8211
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1196 CTRP2 0.5238 4.0831 0.3363 32.922
SNU-245 CTRP2 0.6286 7.1339 -0.1958 38.2604
SNU-1079 CTRP2 0.6293 2.5892 0.6252 36.0896
HuH-28 CTRP2 0.7543 3.1253 0.7384 35.2954
SNU-478 CTRP2 1.0252 3.5149 0.9985 33.527
SNU-869 CTRP2 2.015 6.7791 1.4265 28.8463
HuCC-T1 CTRP2; CCLE 2.9228 4.0034 2.9211 20.8022
SNU-308 CTRP2 3.0386 4.7793 3.0037 20.1427
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NOS-1 [Human HNSCC] GDSC1 -3.1843 -0.4262 -3.2708 52.1208
EW-16 GDSC1 -3.1033 0.6407 -3.3853 51.0661
EW-1 GDSC1 -1.8317 1.7043 -2.3077 37.7957
H-EMC-SS GDSC1 -1.0851 0.9986 -1.2752 27.288
ES4 GDSC1 -1.0331 2.9468 -1.9412 30.9689
MHH-ES-1 CTRP2; CCLE -1.0328 1.9291 -1.0469 47.1716
A-673 CTRP2; CCLE -1.0027 3.1359 -1.09 47.0612
SK-ES-1 GDSC1; CTRP2; CCLE -0.9597 2.6762 -1.0071 46.7345
G-292 clone A141B1 CTRP2 -0.9192 2.4647 -0.9524 46.4486
ES6 GDSC1 -0.912 2.0277 -1.4356 27.315
SK-PN-DW GDSC1 -0.4984 2.967 -1.402 24.8583
SK-N-MC CTRP2 -0.3497 3.537 -0.4424 42.8212
ES8 GDSC1 -0.2722 1.0615 -0.4057 16.7821
MG-63 CTRP2; CCLE -0.059 3.384 -0.1215 40.8363
U2OS CTRP2; CCLE 0.0148 1.9529 0.0129 40.1761
SaOS-2 CTRP2; CCLE 0.04 2.4479 0.0309 40.0304
SJSA-1 GDSC1; CTRP2; CCLE 0.431 4.0784 0.3218 37.7284
Hs 888.T CTRP2 0.8429 3.9493 0.7733 34.8785
ES1 GDSC1 1.0923 7.2041 -2.0255 21.6829
EW-24 GDSC1 1.1458 3.3658 -0.0637 7.8715
SW1353 CTRP2; CCLE 1.3436 3.3452 1.3332 31.3523
EW-3 GDSC1 1.4047 6.9721 -1.6558 18.3974
CAL-78 CTRP2; CCLE 1.4948 3.3024 1.4883 30.3316
EW-22 GDSC1 2.0161 8.2575 -1.8206 17.3708
Hs 822.T CTRP2 2.0616 2.9134 2.0616 26.5341
EW-11 GDSC1 2.0702 7.0409 -1.1816 13.1874
EW-13 GDSC1 2.125 9.8734 -2.5376 20.8855
EW-12 GDSC1 2.2547 12.0651 -3.5249 24.7777
HOS CTRP2; CCLE 2.4046 3.5916 2.4033 24.253
TC-71 GDSC1; CCLE 2.8532 4.6661 2.0417 5.57
ES5 GDSC1 3.2234 10.1574 -1.8845 14.3293
EW-18 GDSC1 4.2783 14.5232 -3.2631 18.4687
ES7 GDSC1 4.3333 6.9572 0.1362 0.8876
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 88 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP2; CCLE -1.3856 1.3047 -1.3912 49.5016
DU4475 GDSC1; CTRP2 -0.4077 2.4745 -0.4268 43.0359
CAL-51 CTRP2 -0.2456 2.6012 -0.2656 41.9616
OCUB-M GDSC1 0.3385 3.0421 -0.6138 15.3055
KPL-1 CTRP2 0.441 5.7837 -0.0016 38.5369
HCC2157 GDSC1 0.6244 2.3123 0.0095 9.2871
Hs 739.T CCLE 0.7774 1.9269 0.7627 19.1515
HCC1143 CTRP2 0.8139 2.9366 0.8053 34.8748
HCC1395 CTRP2; CCLE 0.9498 3.8398 0.8962 34.1167
Hs 578Bst CTRP2 1.2119 3.2888 1.2005 32.2328
MDA-MB-468 CTRP2; CCLE 1.2972 2.9647 1.2943 31.6361
MDA-MB-231 CTRP2 1.5588 4.5682 1.459 30.2179
HDQ-P1 CTRP2; CCLE 1.5698 4.117 1.522 29.9705
MRK-nu-1 GDSC1 1.6024 4.1544 -0.1077 6.7722
Evsa-T GDSC1 1.6025 3.265 0.3217 3.5206
HCC1599 GDSC1 1.6226 6.8786 -1.4379 16.2849
MDA-MB-436 CCLE 1.6779 5.5818 0.491 17.2412
MDA-MB-453 CTRP2; CCLE 1.6837 4.0289 1.6484 29.1697
HCC38 CTRP2 1.6889 3.8619 1.665 29.0968
CAL-85-1 CTRP2; CCLE 1.751 5.4913 1.4975 29.4581
HMC-1-8 CTRP2; CCLE 1.8419 4.288 1.7919 28.1657
BT-549 CTRP2; CCLE 2.097 3.8233 2.0868 26.3321
CAL-120 CTRP2 2.1573 3.6443 2.153 25.9105
HCC70 CCLE 2.1606 5.0881 1.1943 12.0911
AU565 CTRP2; CCLE 2.2072 3.7347 2.2016 25.5827
Hs 578T CTRP2; CCLE 2.2607 4.1453 2.2401 25.2763
HCC1500 GDSC1; CTRP2 2.2838 13.1702 -0.9901 34.485
HCC1806 CTRP2; CCLE 2.2899 4.0246 2.2764 25.0581
COLO 824 GDSC1 2.337 8.323 -1.6158 15.175
HCC2218 GDSC1; CTRP2 2.3786 3.7217 2.3755 24.4324
MDA-MB-157 CTRP2; CCLE 2.5255 4.5535 2.4856 23.5779
HCC1954 CTRP2; CCLE 2.5386 3.8798 2.5347 23.369
HCC202 CTRP2 2.5735 4.8342 2.5053 23.3542
CAL-148 GDSC1 2.6674 4.589 0.3311 1.5143
SK-BR-3 CTRP2; CCLE 2.6846 3.5529 2.6844 22.3841
HCC1937 CTRP2 2.6882 4.6857 2.644 22.5085
HCC1428 CTRP2 2.7643 4.636 2.7289 21.9716
BT-20 CTRP2; CCLE 2.8469 5.0838 2.7624 21.5896
MDA-MB-415 CTRP2; CCLE 2.8671 4.5472 2.8435 21.2466
EFM-192A CTRP2 2.913 4.7321 2.8761 20.9859
UACC-812 GDSC1; CCLE 2.9886 6.2817 1.3496 8.9656
T-47D CTRP2; CCLE 3.0124 4.778 2.9763 20.3214
MDA-MB-361 CTRP2 3.0419 7.4649 2.2938 22.6909
JIMT-1 CTRP2 3.0453 4.4116 3.0354 20.0135
BT-474 GDSC1; CTRP2; CCLE 3.1416 4.5262 3.1292 19.3803
EFM-19 CCLE 3.2747 9.6582 -0.103 15.7339
MFM-223 GDSC1 3.4431 4.9013 0.5317 0.2064
CAMA-1 CTRP2; CCLE 3.6641 4.4137 3.6634 15.8602
ZR-75-30 CTRP2; CCLE 3.7545 5.8273 3.6012 15.787
HCC1187 GDSC1; CCLE 3.7776 10.3024 -0.0251 14.17
HCC1419 CTRP2 4.2449 5.9064 4.1164 12.4349
ZR-75-1 CTRP2; CCLE 4.5836 5.9041 4.4862 10.0699
HCC1569 CCLE 5.1825 7.7333 2.11 1.4158
MDA-MB-175-VII CCLE 5.6308 7.443 2.4115 0.2859
BT 416 CTRP2 -0.5707 2.293 -0.5869 44.1112
BT 482 CTRP2 -0.4882 1.9963 -0.4951 43.5399
BT 239 CTRP2 -0.4771 5.3029 -0.8847 44.1755
BT 440 CTRP2 -0.1762 2.3762 -0.1871 41.4748
BT 231 CTRP2 0.1679 5.2782 -0.177 40.0392
BT 228 CTRP2 0.2689 2.7574 0.2552 38.5207
BT 131 CTRP2 0.3602 3.5183 0.3062 38.0361
BT 271 CTRP2 0.4064 3.6251 0.3453 37.7505
BT 330 CTRP2 0.5572 3.6037 0.5052 36.722
BT 286 CTRP2 0.7836 3.5949 0.7424 35.1823
BT 245 CTRP2 0.8057 3.985 0.7302 35.1445
BT147 CTRP2 1.0391 3.645 1.0047 33.4599
BT 333 CTRP2 1.2267 3.8568 1.1847 32.2357
BT 248 CTRP2 1.2995 4.9093 1.126 32.1831
BT 328 CTRP2 1.511 4.0186 1.4688 30.3429
BT 172 CTRP2 1.6665 3.593 1.6547 29.2054
BT 504 CTRP2 1.706 3.2783 1.7026 28.9144
BT164 CTRP2 1.7352 2.9978 1.7345 28.7108
BT 112 CTRP2 1.7829 2.8976 1.7827 28.3911
BT 187 CTRP2 1.8208 3.7426 1.8069 28.1848
BT 145 CTRP2 1.8225 3.0675 1.8218 28.1293
BT 179 CTRP2 1.8305 3.4994 1.8246 28.0931
BT 159 CTRP2 1.8836 2.8702 1.8835 27.7203
BT 428 CTRP2 1.9744 3.8541 1.9598 27.1636
BT 224 CTRP2 2.15 3.4072 2.1488 25.949
BT 139 CTRP2 2.1671 3.3301 2.1665 25.8331
BT 444 CTRP2 2.172 3.9107 2.1603 25.8376
BT 340 CTRP2 2.2257 4.0385 2.2098 25.4939
BT 232 CTRP2 2.2987 2.9957 2.2987 24.9543
BT 359 CTRP2 2.3365 3.5376 2.3353 24.7066
BT 216 CTRP2 2.5979 3.1693 2.5979 22.9607
BT 422 CTRP2 2.6866 3.0714 2.6866 22.3698
BT 320 CTRP2 2.8277 4.5943 2.7988 21.5272
BT 498 CTRP2 2.8321 5.5144 2.6679 21.9658
⏷ Show the Full List of 88 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 1.9621 3.1115 1.9592 22.0108
Cancer Drug Sensitivity Data Curated from 59 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KS-1 [Human Krukenberg tumour] GDSC1 -2.2831 0.7122 -2.5086 41.9793
D-336MG GDSC1 -0.4883 2.0122 -0.9803 21.9618
SF539 GDSC1; CTRP2 -0.2136 1.4786 -0.214 41.6931
D283 Med GDSC1; CTRP2 -0.211 2.4512 -0.2248 41.7145
GI-1 GDSC1; CCLE 0.2424 2.0187 0.1907 23.9084
SF126 GDSC1; CTRP2; CCLE 0.2917 2.2404 0.289 38.3341
SF268 GDSC1; CTRP2 0.4169 3.2043 0.3872 37.5858
GB-1 GDSC1; CTRP2; CCLE 0.4783 3.493 0.4316 37.2299
CAS-1 GDSC1; CTRP2; CCLE 0.7516 3.5271 0.7139 35.3838
SNB-75 GDSC1; CTRP2 1.0709 4.306 0.9738 33.4522
CCF-STTG1 CTRP2 1.0965 3.6081 1.0668 33.0621
KNS-60 CTRP2; CCLE 1.1225 3.2707 1.1099 32.8321
SNU-738 CTRP2 1.1855 2.6215 1.1847 32.3734
D-263MG GDSC1 1.2202 3.013 0.1706 5.7852
A-172 CTRP2; CCLE 1.2657 3.7695 1.2318 31.9489
Onda 11 GDSC1 1.3119 3.4821 0.0083 6.7589
H4 CCLE 1.368 3.0789 1.1968 14.7913
M059J CCLE 1.3817 3.2173 1.1701 14.8641
42-MG-BA CTRP2; CCLE 1.3911 3.0061 1.3885 31.0096
KNS-81 CTRP2; CCLE 1.4129 5.2148 1.1898 31.594
1321N1 CCLE 1.4882 4.6287 0.7344 16.6325
GaMG CTRP2; CCLE 1.5101 2.389 1.5101 30.2084
DK-MG CTRP2; CCLE 1.538 2.329 1.538 30.0221
Onda 10 GDSC1 1.5648 3.8336 0.0218 5.8906
SNU-201 CTRP2 1.6135 2.8454 1.6131 29.5208
KINGS-1 GDSC1 1.726 5.6889 -0.7704 11.3653
GOS-3 CTRP2 1.7623 5.6437 1.4743 29.4993
Hs 683 CTRP2; CCLE 1.805 3.3044 1.8023 28.2522
KNS-81-FD GDSC1 1.8241 3.973 0.1314 4.3762
KG-1-C CTRP2 1.8412 3.9114 1.8197 28.0742
KALS-1 GDSC1; CTRP2; CCLE 1.877 5.1369 1.7082 28.3355
M059K CTRP2 1.8904 3.045 1.89 27.676
TM-31 CTRP2 1.8918 3.927 1.8712 27.7341
LN-18 CTRP2; CCLE 1.9039 4.1945 1.8653 27.714
SNU-489 CTRP2 1.9355 2.6217 1.9355 27.3741
LN-229 CTRP2; CCLE 1.9685 5.139 1.8067 27.7034
YH-13 CTRP2 1.9839 4.1183 1.9546 27.1498
D-247MG GDSC1 2.0359 9.1548 -2.2496 19.6964
SW1088 CTRP2; CCLE 2.04 4.3459 1.9948 26.83
SNU-1105 CTRP2 2.0475 3.1453 2.0472 26.629
U-118MG CTRP2; CCLE 2.1217 5.2049 1.96 26.6841
U-251MG CTRP2 2.1656 4.0097 2.1492 25.8958
SNU-466 CTRP2 2.2869 3.7157 2.2685 19.7482
GMS-10 CTRP2; CCLE 2.5279 4.429 2.4986 23.5258
KNS-42 GDSC1; CTRP2; CCLE 2.5322 5.4697 2.3516 24.019
YKG-1 CTRP2; CCLE 2.5463 5.9062 2.2637 24.2842
DBTRG-05MG CTRP2; CCLE 2.591 4.6865 2.5413 23.1749
T98G CTRP2; CCLE 2.6126 5.0048 2.5233 23.1666
8-MG-BA GDSC1; CTRP2; CCLE 2.7262 4.1748 2.7177 22.1347
Daoy CTRP2; CCLE 2.7495 5.2166 2.6361 22.338
NMC-G1 GDSC1; CTRP2 2.785 6.0246 2.4927 22.7332
AM-38 GDSC1; CTRP2 2.8356 4.836 2.7834 21.5537
D-502MG GDSC1 2.9599 8.4247 -1.2335 11.0912
ONS-76 GDSC1; CTRP2; CCLE 2.9765 4.5426 2.9575 20.5022
SF295 CTRP2; CCLE 3.048 6.3156 2.6964 21.1995
SW1783 CTRP2 3.255 10.6955 1.1217 26.1877
Becker GDSC1; CTRP2 3.4146 6.7382 2.9589 19.149
U-87MG ATCC GDSC1; CTRP2; CCLE 3.6463 4.5748 3.6434 15.986
MOG-G-CCM CCLE 4.6146 7.1506 2.0656 2.187
⏷ Show the Full List of 59 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 -1.7247 1.4661 -2.1128 36.1722
ETK-1 GDSC1 0.514 7.1484 -2.4881 26.3109
TGBC1TKB GDSC1 1.4871 7.1468 -1.6775 18.245
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2; CCLE -0.7553 1.3923 -0.7572 45.3053
JHUEM-7 CTRP2 0.2408 3.1563 0.2078 38.7665
JHUEM-1 CTRP2 1.288 3.446 1.2726 31.7393
JHUEM-3 CTRP2 1.5812 2.7341 1.581 29.7349
HEC-59 CTRP2; CCLE 1.8365 4.746 1.7305 28.3913
HEC-1-A CTRP2; CCLE 1.8404 4.3589 1.7833 28.1999
TEN CCLE 1.8681 6.6127 0.1812 18.2029
HEC-1-B CTRP2; CCLE 2.0208 4.8037 1.9193 27.1495
ESS-1 CTRP2; CCLE 2.1407 3.3427 2.1399 26.0097
AN3-CA CTRP2; CCLE 2.1477 4.4419 2.0989 26.1247
MFE-296 CTRP2; CCLE 2.2521 4.4695 2.2061 25.4196
HEC-151 CTRP2; CCLE 2.3166 4.3325 2.2856 24.9392
HEC-251 CTRP2; CCLE 2.3185 4.0154 2.3062 24.8637
HEC-6 CTRP2; CCLE 2.3529 3.992 2.3424 24.6281
HEC-50B CTRP2 2.4252 7.5639 1.2503 23.2815
RL95-2 GDSC1; CTRP2; CCLE 2.4524 7.5447 1.6323 26.791
KLE GDSC1; CTRP2; CCLE 2.5738 4.6921 2.5225 23.2949
HEC-265 CTRP2; CCLE 3.1534 4.1906 3.1513 19.2672
HEC-108 CTRP2 3.1948 4.3949 3.1889 19.0039
EFE-184 CTRP2; CCLE 3.256 4.7987 3.23 18.6641
MFE-280 CCLE 3.2612 5.7472 1.8375 5.678
MFE-319 CTRP2; CCLE 3.2889 4.829 3.2619 18.4482
EN CTRP2; CCLE 6.2728 12.3536 3.0781 11.9599
Ishikawa (Heraklio) 02 ER- CTRP2; CCLE 3.7187 5.2052 3.6766 15.6366
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1 -0.7725 1.3217 -1.0309 23.8632
LB1047-RCC GDSC1 -0.4301 2.0534 -0.9358 21.3455
LB996-RCC GDSC1 -0.4183 2.3122 -1.0321 21.9564
A-704 GDSC1 -0.293 3.1565 -1.2821 23.0303
LB2241-RCC GDSC1 -0.0959 5.6422 -2.2875 27.9475
TK-10 GDSC1 0.0903 3.0167 -0.8396 18.097
TUHR14TKB CTRP2 0.2135 5.5973 -0.2027 39.9108
BB65-RCC GDSC1 0.8746 5.8417 -1.5261 19.5266
SNU-1272 CTRP2 1.082 5.6029 0.7427 34.1336
UO-31 CTRP2 1.2439 3.1836 1.2363 32.0071
KMRC-2 CTRP2; CCLE 1.4661 2.8819 1.465 30.5049
HA7-RCC GDSC1 1.534 7.1549 -1.6446 17.8837
OS-RC-2 GDSC1 1.544 11.2936 -3.7008 27.601
A-498 GDSC1 1.6484 3.6583 0.1647 4.5761
RCC10RGB GDSC1; CTRP2 1.8735 4.3741 1.8167 27.978
CAL-54 CTRP2 2.1094 3.3399 2.1084 26.2186
KMRC-20 CTRP2 2.4287 4.097 2.3817 18.8404
VMRC-RCZ CTRP2; CCLE 2.5372 3.7388 2.5354 23.3714
Caki-2 CTRP2; CCLE 2.5789 3.5227 2.5787 23.0884
VMRC-RCW CTRP2; CCLE 2.5922 4.122 2.5825 23.0314
BFTC-909 CTRP2; CCLE 2.6422 3.6644 2.6415 22.6683
ACHN CTRP2; CCLE 2.6603 4.4842 2.6326 22.6386
769-P CTRP2; CCLE 2.6681 3.6295 2.6678 22.4943
KMRC-1 CTRP2; CCLE 2.6795 3.5116 2.6794 22.4178
TUHR10TKB CTRP2 2.7076 3.9559 2.7044 22.241
786-O CTRP2; CCLE 3.2521 4.0879 3.2516 18.6043
Caki-1 CTRP2 3.2951 4.6106 3.2831 18.3565
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CL-34 CTRP2 -5.1198 2.988 -5.4617 68.1167
SW48 CTRP2; CCLE -2.3136 1.8303 -2.358 55.467
NCI-H716 GDSC1; CTRP2 -2.0143 1.8343 -2.0491 53.5863
COLO 320HSR GDSC1 -1.9654 0.7804 -2.179 38.1837
COLO 320 CTRP2; CCLE -1.7522 2.9097 -1.8571 51.8317
SK-CO-1 CTRP2; CCLE -1.6532 2.0649 -1.6886 51.2523
HT115 CTRP2 -1.3848 1.3393 -1.391 49.4968
GP2d CTRP2 -1.1372 3.388 -1.2595 47.9552
SNU-C1 GDSC1; CTRP2 -1.033 3.7688 -1.198 47.3297
HT-55 CTRP2 -0.7743 3.811 -0.9276 45.6756
LS1034 GDSC1; CTRP2 -0.3699 3.2002 -0.4314 42.8855
T84 CTRP2; CCLE -0.352 3.4807 -0.4389 42.8238
LS513 GDSC1; CTRP2; CCLE -0.2603 1.7021 -0.2619 42.0078
SW948 CTRP2 -0.1809 3.8811 -0.3042 41.7855
COLO205 CTRP2; CCLE -0.1645 1.5723 -0.1651 41.3667
SW403 CCLE 0.0354 3.5083 -0.3872 27.3406
KM12 GDSC1; CTRP2 0.1356 1.7865 0.135 39.3672
NCI-H747 GDSC1; CTRP2; CCLE 0.5243 3.5825 0.4725 36.9397
COLO 678 CTRP2; CCLE 0.5529 5.6896 0.1444 37.7422
C2BBe1 GDSC1; CTRP2; CCLE 0.5657 4.3708 0.4251 36.9308
CL-11 GDSC1; CTRP2 0.64 4.9481 0.4055 36.7123
COLO201 CTRP2; CCLE 1.0199 2.9573 1.014 33.4938
SW1417 CTRP2; CCLE 1.3361 4.0703 1.2808 31.5513
SNU-407 CTRP2 1.3372 3.8804 1.2982 31.4899
LS180 CTRP2 1.3583 3.8603 1.3217 31.3414
SNU-C2A CTRP2; CCLE 1.3659 5.8291 0.9958 32.3743
LoVo CTRP2 1.3744 4.0393 1.3239 31.2804
CCK-81 CCLE 1.485 5.2215 0.4661 17.9948
SW620 CTRP2; CCLE 1.6717 4.3118 1.6102 29.3381
LS411N GDSC1; CTRP2; CCLE 1.6724 4.0911 1.6317 29.2631
HCC-56 CTRP2; CCLE 1.6745 4.8473 1.5408 29.5624
SNU-C5 CTRP2 1.7477 4.3577 1.6855 28.8341
RCM-1 [Human ESC] CTRP2 1.7547 4.1241 1.7151 28.7115
NCI-H508 CTRP2 1.8257 4.1739 1.7853 28.2411
RKO GDSC1; CTRP2; CCLE 1.8638 5.2703 1.6677 28.5161
SW480 CCLE 1.9484 5.9325 0.586 15.9106
SNU-61 CTRP2 1.9905 4.7916 1.8886 27.3525
LS123 GDSC1; CTRP2; CCLE 2.0526 3.4636 2.0501 26.6022
HCT 8 CTRP2 2.0563 2.8876 2.0563 26.5692
SNU-503 CTRP2 2.1195 6.1681 1.7266 27.4967
SNU-C2B GDSC1; CCLE 2.2716 9.3034 -0.7776 21.4641
OUMS-23 CTRP2 2.3079 3.0615 2.3079 24.8931
HCT 15 CTRP2; CCLE 2.3284 3.6673 2.3257 24.7656
SNU-C4 CTRP2 2.3737 2.899 2.3737 24.4545
HT-29 CTRP2; CCLE 2.6075 3.1166 2.6075 22.8973
MDST8 GDSC1; CTRP2 2.8331 4.3771 2.8187 21.4425
DLD-1 CTRP2 2.9967 4.1119 2.9942 20.3125
HCT 116 CTRP2; CCLE 3.1448 3.9049 3.1446 19.318
CW-2 GDSC1 3.7443 7.8254 -0.4881 4.701
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.3874 4.951 0.4944 0.3053
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2; CCLE -0.4177 3.7955 -0.5453 43.3364
Hep 3B2.1-7 CTRP2; CCLE -0.0334 2.5798 -0.0477 40.5348
Li-7 CTRP2 0.0314 1.8675 0.0302 40.0634
SNU-761 CTRP2 0.2153 5.9042 -0.2794 40.0703
JHH-7 CCLE 0.3268 2.7745 0.141 23.786
Hep-G2 CCLE 0.5183 5.3473 -0.5777 26.311
HuH-1 CTRP2; CCLE 0.8439 4.457 0.7102 35.0728
JHH-5 CTRP2; CCLE 1.1532 4.281 1.0644 32.8783
SNU-886 CTRP2 1.196 3.4862 1.1763 67.7237
HuH-6 CTRP2 1.2727 3.7774 1.2385 31.9035
SNU-387 CTRP2; CCLE 1.4119 4.6015 1.2972 31.2445
JHH-1 CTRP2 1.5997 4.1984 1.5457 29.7921
SNU-449 CTRP2; CCLE 1.6647 2.5071 1.6647 29.1781
SNU-398 CTRP2; CCLE 1.7467 4.5586 1.6606 28.9217
SNU-423 CTRP2; CCLE 2.1838 3.5487 2.1814 25.7278
JHH-4 CTRP2; CCLE 2.2161 3.4055 2.2152 25.5077
HLF CTRP2; CCLE 2.3717 4.1791 2.353 24.5307
Hep-G2/C3A CCLE 2.402 8.8519 -0.4381 19.5943
JHH-2 CTRP2; CCLE 2.4607 4.1652 2.4456 23.9256
HLE CCLE 2.573 5.2361 1.5088 9.2083
SNU-475 CTRP2; CCLE 3.144 7.7087 2.3084 22.3438
PLC/PRF/5 CTRP2; CCLE 3.4994 4.6723 3.4904 16.9853
SK-HEP-1 CTRP2; CCLE 3.6207 4.7973 3.6093 16.1853
JHH-6 CTRP2; CCLE 3.8057 4.5056 3.8051 14.9163
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2228 CTRP2; CCLE -4.6796 4.2655 -5.2257 65.2066
NCI-H1341 CTRP2; CCLE -2.8249 0.3405 -2.831 58.9745
LC-2/ad GDSC1 -2.0371 -0.2184 -2.0783 38.1984
DMS 454 CTRP2 -1.6695 4.7285 -2.0547 51.1947
CAL-12T CTRP2; CCLE -1.5739 2.3705 -1.6247 50.7315
LCLC-97TM1 CTRP2 -1.5626 4.4901 -1.8904 50.5951
NCI-H1975 GDSC1; CTRP2; CCLE -1.548 0.1451 -1.5481 50.5818
NCI-H3255 CCLE -0.9126 1.045 -0.9344 33.6951
NCI-H2009 CTRP2; CCLE -0.8699 1.9595 -0.8818 46.0878
HCC1588 CTRP2 -0.8141 1.7974 -0.8215 45.7088
Lu-134-A GDSC1 -0.5683 5.4237 -2.6243 31.7407
HCC827 CTRP2; CCLE -0.5397 1.6226 -0.5421 43.8709
NCI-H524 GDSC1 -0.2637 5.3615 -2.3064 28.8206
DV-90 CTRP2; CCLE -0.18 2.6819 -0.2017 41.5303
NCI-H1734 CTRP2 -0.1651 2.8639 -0.2266 37.389
HCC44 CTRP2; CCLE -0.1344 2.2217 -0.1411 41.1845
NCI-H1623 CTRP2 -0.0757 3.5503 -0.1547 40.9888
NCI-H847 GDSC1 -0.072 1.328 -0.2734 14.7578
HCC4006 CTRP2; CCLE -0.0503 3.2348 -0.1002 40.7458
LOU-NH91 CTRP2; CCLE -0.0411 2.5531 -0.0546 40.5834
LC-1F CTRP2 -0.0031 12.4549 -2.9728 44.3925
NCI-H358 CTRP2; CCLE -0.0002 3.3034 -0.0532 40.4224
LXF 289 GDSC1; CTRP2 0.0666 2.2841 0.0613 39.8418
DMS 53 CTRP2 0.0892 5.793 -0.3878 40.8156
NCI-H810 CTRP2; CCLE 0.1237 3.1031 0.0897 39.5472
NCI-H187 GDSC1 0.1384 3.926 -1.2311 20.6463
CPC-N GDSC1 0.1702 4.4554 -1.4601 22.0228
PC-14 CTRP2; CCLE 0.1834 2.3422 0.1784 39.0627
HOP-62 GDSC1; CTRP2 0.2464 3.7798 0.1612 38.8798
NCI-H1184 CTRP2; CCLE 0.2751 2.6292 0.2653 38.4674
NCI-H720 GDSC1 0.3302 3.3935 -0.7923 16.6734
NCI-H1304 GDSC1 0.3404 2.343 -0.2775 12.7456
NCI-H2106 CTRP2 0.4297 4.682 0.2279 37.9955
HCC15 CTRP2; CCLE 0.4337 4.113 0.3202 37.7234
NCI-H2286 CTRP2; CCLE 0.4372 2.8522 0.4239 37.3988
Lu-99 CTRP2; CCLE 0.4422 2.7018 0.4333 37.3517
NCI-H211 GDSC1; CTRP2; CCLE 0.4497 3.2466 0.4187 37.3714
NCI-H2085 CCLE 0.552 3.3893 0.2128 22.5667
NCI-H1048 CCLE 0.5784 2.5482 0.4655 21.2968
COR-L47 CTRP2 0.5823 4.8753 0.3571 37.0631
NCI-H1876 GDSC1 0.5854 3.3835 -0.5527 13.7936
COLO 668 GDSC1; CTRP2 0.6132 5.4887 0.2591 37.2142
COR-L95 GDSC1; CTRP2 0.615 5.3769 0.2872 37.132
VMRC-LCD CTRP2; CCLE 0.634 4.6565 0.4527 36.5997
EKVX GDSC1; CTRP2 0.662 3.8 0.5975 36.0643
GLC-82 CCLE 0.6953 3.1875 0.4312 20.9907
NCI-H1355 GDSC1; CTRP2; CCLE 0.7205 7.4298 -0.1955 37.9125
NCI-H841 CTRP2 0.726 5.2414 0.4382 36.3022
EPLC-272H CTRP2 0.7829 4.5167 0.6358 35.5168
NCI-H69 GDSC1; CTRP2 0.785 3.4801 0.7517 35.1478
LUDLU-1 CTRP2; CCLE 0.8315 3.7103 0.7833 34.8861
HOP-92 CTRP2 0.845 3.3855 0.8196 34.7226
A-549 CTRP2; CCLE 0.848 3.3756 0.8232 34.7006
NCI-H526 GDSC1; CTRP2 0.8566 3.8896 0.7937 34.7663
NCI-H510A GDSC1 0.8618 5.4945 -1.3634 18.5202
DMS 114 GDSC1; CTRP2; CCLE 0.879 4.132 0.7912 34.6965
SK-MES-1 CTRP2; CCLE 0.8791 3.4113 0.8533 34.4969
NCI-H727 CTRP2; CCLE 0.8949 4.2867 0.7888 34.649
NCI-H1963 GDSC1 0.913 2.746 0.0535 7.785
NCI-H2029 CTRP2 0.9455 5.2467 0.6756 34.8174
SK-LU-1 CTRP2; CCLE 0.9546 3.8937 0.8964 34.0997
NCI-H1693 CTRP2; CCLE 0.9743 4.877 0.7807 34.3962
NCI-H2122 CTRP2; CCLE 0.9833 2.5924 0.9818 33.7227
NCI-H1435 CTRP2 1.0254 5.1729 0.778 34.2255
NCI-H1666 GDSC1; CTRP2; CCLE 1.0337 4.4557 0.9137 33.7724
Lu-65 GDSC1; CTRP2 1.052 3.9756 0.991 33.4607
NCI-H2141 GDSC1; CTRP2 1.0615 4.4704 0.9413 33.5886
HCC2279 CTRP2 1.0735 2.949 1.0685 33.1334
COLO 677 CCLE 1.0843 2.8046 0.9593 17.0109
NCI-H2110 CTRP2 1.086 3.5544 1.0591 33.1227
RERF-LC-Ad2 CTRP2 1.158 3.8944 1.1097 32.7141
NCI-H1436 GDSC1 1.1618 2.4347 0.4126 4.0784
HCC1833 CTRP2 1.1793 7.334 0.3341 34.9465
COLO 699 CTRP2; CCLE 1.1858 4.8675 1.0109 32.9404
NCI-H23 GDSC1; CTRP2; CCLE 1.2107 4.3972 1.1107 32.5328
NCI-H292 CTRP2 1.2137 4.0609 1.1529 32.3842
SW1271 CTRP2; CCLE 1.2332 4.3289 1.1435 32.3499
COR-L51 CTRP2 1.2405 4.0074 1.1862 32.1846
HARA [Human squamous cell lung carcinoma] CTRP2; CCLE 1.2849 4.3509 1.1957 32.0042
ChaGo-K-1 CTRP2 1.2941 6.2772 0.7949 33.2383
NCI-H2087 CTRP2; CCLE 1.3025 6.2181 0.821 33.1306
NCI-H2081 GDSC1; CTRP2 1.3593 4.5266 1.2516 31.5709
NCI-H1836 GDSC1 1.3606 4.5066 -0.4626 10.2416
Lu-139 GDSC1 1.417 3.1405 0.2543 4.532
HCC2935 CTRP2; CCLE 1.424 3.7046 1.4 30.8618
HCC1438 CTRP2 1.4619 4.7466 1.3286 30.9739
NCI-H1573 CTRP2; CCLE 1.4679 4.9154 1.3067 31.0264
NCI-H2135 GDSC1 1.4802 5.3029 -0.7655 12.1138
T3M-10 CTRP2; CCLE 1.4945 2.4225 1.4945 30.3123
NCI-H345 GDSC1 1.517 3.084 0.351 3.5213
SW1573 CCLE 1.5496 4.3216 0.9305 15.4346
HCC95 CTRP2 1.5974 3.9631 1.5633 29.7408
NCI-H1703 CTRP2; CCLE 1.6 3.5131 1.5895 29.6446
NCI-H522 CTRP2; CCLE 1.6089 5.3676 1.3704 30.3483
NCI-H1563 CTRP2; CCLE 1.617 4.2868 1.5551 29.7034
LK2 CTRP2 1.6237 2.0699 1.6237 29.4512
IST-SL1 GDSC1 1.6382 3.8864 0.0479 5.4856
NCI-H1568 CTRP2; CCLE 1.6402 4.4553 1.5604 29.6092
EBC-1 CTRP2; CCLE 1.6448 3.8223 1.6217 29.3882
NCI-H209 GDSC1 1.6511 4.4853 -0.2344 7.5958
NCI-H2405 CTRP2 1.672 4.796 1.5464 29.5519
NCI-H2342 CTRP2 1.6965 9.8616 -0.0979 34.2917
NCI-H1792 CTRP2; CCLE 1.7159 4.1646 1.6709 28.9881
NCI-H2291 CTRP2 1.73 4.7809 1.4957 24.524
NCI-H1650 GDSC1; CTRP2; CCLE 1.7345 4.1046 1.6955 28.8437
LB647-SCLC GDSC1 1.7668 7.2599 -1.5162 16.3113
NCI-H1581 GDSC1; CTRP2; CCLE 1.7747 4.3791 1.7117 28.6571
NCI-H650 CTRP2; CCLE 1.7936 5.1258 1.62 28.906
HCC1195 CTRP2 1.8053 6.7369 1.2121 30.2252
HCC366 CTRP2 1.8112 4.7258 1.7064 28.5554
IA-LM GDSC1; CTRP2; CCLE 1.8322 3.37 1.8288 28.0735
Calu-6 GDSC1; CTRP2; CCLE 1.8803 4.1104 1.8473 27.8525
NCI-H1694 GDSC1; CTRP2; CCLE 1.8864 3.7682 1.8731 27.7455
NCI-H446 GDSC1; CTRP2 1.8984 4.2348 1.8562 27.7628
NCI-H520 CTRP2; CCLE 1.906 4.5117 1.8358 27.807
IST-SL2 GDSC1 1.9406 4.9294 -0.2469 6.8801
NCI-H441 CTRP2; CCLE 1.9502 6.0569 1.5728 28.5605
NCI-H2170 CTRP2; CCLE 1.9583 4.3631 1.9072 27.3939
HCC2108 CTRP2 1.9956 5.0129 1.8586 27.4382
NCI-H889 CTRP2 2.0201 6.543 1.5069 28.5603
NCI-H1155 GDSC1; CTRP2; CCLE 2.0498 4.0801 2.0256 26.6935
NCI-H2172 CTRP2; CCLE 2.0568 7.3236 1.2866 29.1766
NCI-H1755 CTRP2 2.0676 3.7253 2.0599 26.5195
NCI-H322M GDSC1 2.0698 6.8526 -1.0897 12.5687
NCI-H1092 GDSC1; CTRP2; CCLE 2.0974 6.2626 1.6754 27.7425
Hs 229.T CCLE 2.0987 3.6545 1.7839 9.2413
NCI-H2023 CTRP2; CCLE 2.1054 5.1195 1.9582 26.7428
NCI-H1105 CTRP2 2.1056 4.5592 2.0418 26.456
NCI-H647 CTRP2; CCLE 2.1317 4.5977 2.065 26.2921
NCI-H1915 CTRP2; CCLE 2.1849 3.7902 2.1775 25.7375
Calu-3 CTRP2; CCLE 2.1851 3.5544 2.1826 25.7195
NCI-H838 CTRP2 2.1866 3.6322 2.1829 25.7134
MOR/CPR CTRP2; CCLE 2.1908 3.9689 2.1771 25.7192
NCI-H1869 GDSC1; CTRP2; CCLE 2.2409 6.8553 1.6468 27.3908
NCI-H2171 GDSC1 2.2604 7.0255 -1.0379 11.6652
COR-L105 CTRP2; CCLE 2.3276 3.9325 2.3186 24.7921
NCI-H661 CTRP2; CCLE 2.354 5.3789 2.0105 20.5028
Calu-1 CTRP2; CCLE 2.3642 4.9104 2.2712 24.8334
NCI-H1770 GDSC1 2.3889 4.3603 0.2874 2.1623
NCI-H1944 CTRP2; CCLE 2.3988 3.7125 2.3961 24.2966
NCI-H226 GDSC1; CTRP2; CCLE 2.3993 6.6013 1.9014 26.0169
COR-L279 CTRP2 2.4011 4.592 2.3508 52.0126
NCI-H2196 GDSC1; CTRP2 2.4156 3.8973 2.4094 24.1961
DMS 79 GDSC1 2.4332 4.838 0.1028 3.2668
NCI-H146 CTRP2 2.4814 3.9156 2.4758 23.7559
Sq-1 CTRP2; CCLE 2.4815 4.0099 2.4733 23.764
RERF-LC-MS CTRP2; CCLE 2.4858 3.7732 2.4831 23.7169
NCI-H1838 GDSC1; CTRP2 2.5077 4.9068 2.4253 23.8414
HCC1171 CTRP2 2.7043 6.1069 2.382 23.3758
RERF-LC-A1 CTRP2; CCLE 2.7138 4.6218 2.6771 22.3127
RERF-LC-Ad1 CTRP2 2.7475 3.4106 2.7472 16.3957
NCI-H2030 CTRP2; CCLE 2.7563 4.8279 2.7004 22.0947
NCI-H128 GDSC1 2.7931 5.7275 -0.0896 3.8623
NCI-H322 CTRP2; CCLE 2.8169 6.0936 2.5086 22.5786
HCC33 GDSC1 2.8202 7.7398 -1.0005 9.9283
NCI-H1793 CTRP2; CCLE 2.8504 4.2246 2.8429 21.3038
COR-L23 CCLE 2.8634 5.769 1.5 8.4722
LCLC-103H CTRP2; CCLE 2.8818 3.9462 2.8804 21.0746
NCI-H1373 CTRP2; CCLE 2.9024 5.9418 2.6429 21.8356
NCI-H1395 CTRP2 2.9384 8.814 1.6384 25.338
SHP-77 GDSC1; CTRP2; CCLE 3.0346 4.2474 3.0299 20.0672
NCI-H1651 CTRP2; CCLE 3.1339 5.1744 3.0564 19.6537
NCI-H196 CTRP2 3.2313 4.4605 3.2241 18.7654
BEN CTRP2 3.2591 3.8469 3.259 18.5564
COR-L88 GDSC1 3.2806 4.8109 0.5042 0.3233
Ms-1 GDSC1 3.4021 15.5876 -4.4016 24.7668
SBC-1 GDSC1 3.4043 5.0606 0.4621 0.3803
NCI-H1299 GDSC1; CTRP2; CCLE 3.5553 8.3673 2.4694 20.5959
DMS 273 CTRP2 3.5905 11.5667 1.043 25.5441
NCI-H748 GDSC1 3.7296 6.1852 0.1778 1.1639
NCI-H1339 CTRP2; CCLE 3.761 7.5095 3.0416 17.8528
NCI-H460 CTRP2; CCLE 3.7763 4.9855 3.7588 15.1691
HCC78 CTRP2; CCLE 3.9495 10.3241 1.9802 21.3847
SW900 CCLE 4.2488 6.1668 2.2964 1.6074
KNS-62 CTRP2; CCLE 4.2548 5.2703 4.2359 11.9862
NCI-H2444 CTRP2; CCLE 4.2882 12.912 1.056 23.7454
NCI-H1648 GDSC1; CCLE 4.3884 14.9533 -1.8627 22.5829
NCI-H82 GDSC1 4.3915 17.0595 -4.409 22.4728
NCI-H64 GDSC1 4.4497 11.8042 -1.8695 11.4202
SBC-5 CTRP2; CCLE 4.4808 4.9194 4.4807 10.4173
LC-1/sq-SF CTRP2; CCLE 4.5477 8.6366 3.3583 14.5468
Lu-165 GDSC1 5.3273 15.4583 -3.0198 15.184
Hs 888.Lu CTRP2 1.9023 6.0661 1.5181 28.8989
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 1.4815 6.4892 -1.3543 16.2145
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 -0.3644 1.9347 -0.369 42.71
H-STS CTRP2 2.0208 3.6327 2.0148 26.8258
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 0.2617 3.1541 0.2295 38.6251
COV362 CTRP2 0.3238 3.8889 0.231 38.3898
SNU-119 CTRP2 0.3864 2.7992 0.3737 37.7354
Kuramochi GDSC1; CTRP2; CCLE 0.645 3.2346 0.6211 36.0491
COV504 CCLE 0.9151 3.5579 0.5511 19.583
OAW28 CTRP2 0.9696 5.9628 0.5282 35.1605
A2780 CTRP2; CCLE 0.9979 3.439 0.9745 33.6979
Caov-3 CTRP2 1.033 3.7728 0.9889 33.5321
IGROV-1 CTRP2; CCLE 1.0623 3.6809 1.0264 33.3099
OVCAR-3 CCLE 1.1118 4.5701 0.3695 19.7487
COV434 CTRP2 1.1709 4.519 1.0513 32.8608
FU-OV-1 CTRP2; CCLE 1.2328 5.6886 0.8861 33.1715
TOV-21G CCLE 1.2501 3.1152 1.0576 15.902
RMG-I CTRP2 1.2787 4.7939 1.1238 32.2604
OVCAR-4 GDSC1; CTRP2; CCLE 1.297 4.78 1.1458 32.1271
OV7 CTRP2 1.5743 4.3903 1.4982 30.0354
TOV-112D CTRP2; CCLE 1.8141 4.6076 1.726 28.4796
OV-90 CTRP2; CCLE 1.8318 4.0996 1.7975 28.1797
JHOM-1 CTRP2 1.9042 3.688 1.8943 27.6157
COV644 CTRP2 2.0785 4.5397 2.0154 26.6339
OVCAR-5 CTRP2 2.0874 3.3204 2.0864 26.3655
COV318 CCLE 2.1737 5.1483 1.1782 12.1361
OAW42 CTRP2 2.2444 4.1143 2.225 25.3812
JHOS-4 CCLE 2.3106 5.9307 0.9268 13.0571
JHOS-2 CTRP2; CCLE 2.3123 3.1122 2.3122 24.864
OVMANA CCLE 2.3599 4.7332 1.5556 9.5796
OC 314 CTRP2; CCLE 2.3896 2.9514 2.3896 24.349
TYK-nu CTRP2; CCLE 2.4164 4.3671 2.3871 24.2685
MCAS CTRP2; CCLE 2.4201 4.677 2.3615 24.3435
SNU-8 CTRP2 2.508 3.8122 2.505 23.5699
EFO-21 CTRP2; CCLE 2.5749 4.5515 2.5377 23.2394
ONCO-DG-1 CTRP2; CCLE 2.5899 4.5723 2.5515 23.1439
SK-OV-3 CTRP2; CCLE 2.6216 4.2757 2.6058 22.8558
HEY A8 CTRP2; CCLE 2.6303 4.4162 2.6063 22.8257
OVTOKO CTRP2; CCLE 2.643 4.9933 2.5575 22.9511
DOV13 CTRP2; CCLE 2.7256 5.1852 2.6157 22.485
OVCAR-8 CTRP2; CCLE 2.885 4.1656 2.8798 21.0656
OVK18 CTRP2 2.8946 4.0419 2.8921 20.9928
OVSAHO CTRP2; CCLE 3.0366 7.6036 2.2351 22.9212
SNU-840 CTRP2 3.0828 5.2576 2.9882 20.0531
OVISE CTRP2 3.1393 3.9619 3.139 19.355
OV56 CTRP2 3.1693 4.5217 3.1579 19.1926
EFO-27 CTRP2; CCLE 3.2122 5.4911 3.0851 19.3049
JHOC-5 CTRP2 3.3092 3.9288 3.3092 18.2221
ES2 CTRP2 4.1105 5.379 4.0713 13.0168
ES-2 GDSC1; CCLE 4.7877 7.3283 2.0815 1.9182
OC 315 CCLE 5.2041 6.8023 2.4785 0.2947
OC 316 CCLE 5.4295 6.8942 2.5293 0.1477
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 1.4963 4.2428 1.4322 30.5142
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 2.0596 3.7237 2.0518 26.5732
Aska-SS CTRP2 2.4316 3.0376 2.4316 24.0691
Rh41 CTRP2 -2.7051 -1.6592 -2.7051 58.2904
MFH-ino GDSC1 -1.8403 5.5156 -3.911 42.2962
Tm87-16 CTRP2 -1.4575 1.6435 -1.4713 49.9792
SW982 GDSC1; CTRP2 -1.2516 2.3502 -1.2894 48.6352
SW872 GDSC1 -0.7617 2.34 -1.4022 26.2637
Rh18 CTRP2 -0.303 4.7934 -0.5857 42.893
G-401 CTRP2; CCLE 0.0072 4.0562 -0.127 40.5818
Rh30 CCLE 0.1504 1.508 0.1382 24.5256
BT-16 CTRP2 0.3388 3.08 0.3133 38.0924
VA-ES-BJ GDSC1 0.413 2.5725 -0.3165 12.7176
RD CTRP2; CCLE 0.4993 5.175 0.2061 37.7875
TTC-709 CTRP2 0.5328 2.7914 0.5232 36.7502
TE 441.T GDSC1; CTRP2 0.6571 4.4852 0.5057 36.3599
TE 617.T CTRP2; CCLE 0.7661 2.7519 0.7608 35.1822
GCT CTRP2; CCLE 0.93 3.3456 0.9092 34.1417
A-204 CTRP2; CCLE 1.3289 3.6229 1.3063 31.4908
KYM-1 GDSC1; CTRP2; CCLE 2.0238 4.0466 2.0008 26.8628
G-402 CTRP2; CCLE 2.1326 3.4019 2.1313 26.0655
Hs 729.T CTRP2; CCLE 2.1453 4.3915 2.1011 26.125
SW684 GDSC1 2.164 8.6108 -1.8842 17.2838
EW-8 GDSC1 2.3315 7.5927 -1.2634 12.9654
BT-12 CTRP2 2.3713 2.7832 2.3713 24.4706
SK-LMS-1 GDSC1; CTRP2; CCLE 2.7523 6.9875 2.1561 24.0421
HT-1080 CTRP2; CCLE 2.9047 3.9166 2.9037 20.9205
RKN CTRP2; CCLE 3.3357 4.0504 3.3356 18.046
SK-UT-1 GDSC1; CTRP2 3.4205 6.1681 3.1461 18.4443
MES-SA CTRP2; CCLE 7.2269 8.4314 5.6336 0.3997
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1; CTRP2; CCLE -0.0268 3.3332 -0.0834 40.6079
IST-Mes1 GDSC1; CTRP2; CCLE 0.6944 4.2878 0.5747 36.019
NCI-H28 CTRP2; CCLE 0.8334 3.4379 0.8045 34.8112
MSTO-211H GDSC1; CTRP2; CCLE 0.9516 2.8039 0.9476 33.9423
JL-1 CTRP2 1.0715 3.3616 1.054 33.1885
NCI-H2052 CTRP2; CCLE 1.5925 4.1783 1.5401 29.8347
ACC-MESO-1 CTRP2 1.787 3.3257 1.7838 28.3739
IST-Mes2 CCLE 1.8103 3.8417 1.4037 12.1536
NCI-H2452 CTRP2; CCLE 2.0648 4.5068 2.0046 26.7156
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -2.2765 -0.5713 -2.2989 41.0754
DU145 CTRP2; CCLE 1.6328 5.1454 1.4422 30.0304
22Rv1 CTRP2; CCLE 1.6619 6.2582 1.2016 30.7281
PC-3 CCLE 2.6787 6.3143 1.0681 11.2809
LNCaP clone FGC GDSC1; CTRP2 3.8582 6.8248 3.4077 16.1895
PaCa-3 CTRP2 4.4926 8.0491 3.5713 13.8353
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 1.3099 2.8425 1.3034 26.6787
A-253 GDSC1; CCLE 3.1683 4.7824 2.2449 3.6916
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -1.1885 0.2061 -1.2276 27.6034
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-StC-K140 CTRP2 -3.8456 -0.3028 -3.8526 65.4725
HSC-39 GDSC1 -1.3737 0.2373 -1.4291 30.0196
GSS CTRP2 -0.8219 1.2772 -0.8233 45.7477
ECC10 CTRP2 -0.4843 4.1839 -0.6724 43.8764
SNU-16 GDSC1; CTRP2; CCLE -0.3341 2.6106 -0.3569 42.5563
HGC-27 CTRP2; CCLE -0.1706 1.6447 -0.1714 41.4077
AZ-521 CCLE -0.1533 1.8259 -0.2061 27.3105
HuG1-N CTRP2 0.0208 5.1789 -0.3149 40.9517
BGC-823 CCLE 0.1084 1.9403 0.058 25.053
SNU-1 GDSC1; CTRP2; CCLE 0.5394 5.6355 0.1432 37.7966
SNU-668 CTRP2 0.6756 4.1338 0.4908 31.8372
GCIY GDSC1; CCLE 0.8236 6.2516 -0.6676 25.5924
SNU-620 CTRP2 0.9496 2.3783 0.949 33.9443
KATO III CTRP2 0.9731 4.6088 0.8254 34.2615
SNU-719 CTRP2 0.9881 5.1376 0.7448 34.4579
NCI-N87 GDSC1; CTRP2; CCLE 1.045 4.8355 0.8645 33.889
RF-48 GDSC1 1.1846 2.9289 0.1848 5.7912
Fu97 CTRP2; CCLE 1.2738 2.907 1.2714 31.7902
IM95 CTRP2; CCLE 1.3155 4.6092 1.1927 31.9115
SNU-601 CTRP2 1.6117 4.2645 1.5518 29.7322
23132/87 CTRP2 1.6457 3.8804 1.6191 29.3935
LMSU CTRP2 1.6547 2.8037 1.6544 29.2459
OCUM-1 CTRP2; CCLE 1.6798 5.7789 1.351 30.1796
MKN74 CTRP2; CCLE 1.7332 5.7816 1.4086 29.8137
SNU-216 CTRP2 1.8171 3.4141 1.8127 28.1776
KE-39 CTRP2; CCLE 2.0894 6.1106 1.7099 27.6494
MKN7 CTRP2; CCLE 2.1268 5.7318 1.8502 27.047
MKN1 CTRP2 2.3772 4.3973 2.3437 24.5439
RERF-GC-1B CCLE 2.3804 5.4573 1.2232 11.2845
AGS CTRP2 2.407 3.7307 2.4042 24.2422
GSU CTRP2 2.4343 3.8713 2.4291 24.0681
Hs 746.T CTRP2; CCLE 2.5969 4.1503 2.5862 23.0034
NUGC-3 CTRP2; CCLE 2.6994 4.1621 2.6907 22.3137
ECC12 CTRP2 2.6998 4.3828 2.6806 22.3468
NUGC-4 CTRP2; CCLE 2.7124 4.6916 2.6689 22.3448
SH-10-TC CTRP2; CCLE 2.9386 5.2076 2.8412 21.0232
SNU-5 GDSC1; CTRP2 3.1939 4.6616 3.1754 19.0522
MKN45 CTRP2; CCLE 7.1061 11.5444 4.1211 6.246
SNU-1077 CTRP2 1.0665 2.7922 1.0638 33.1724
SNU-685 CTRP2 1.7874 2.6229 1.7874 28.3609
SNG-M CTRP2; CCLE 2.333 4.3231 2.3034 24.825
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1 0.1129 6.548 -2.544 28.2455
ML-1 [Human leukemia] CTRP2 0.7943 9.1293 -0.7467 38.7695
TT CTRP2 0.8404 3.7662 0.7879 34.8407
SW579 CTRP2; CCLE 1.0123 2.5516 1.0113 33.5279
B-CPAP CTRP2; CCLE 1.3413 3.8647 1.3037 31.4582
TT2609-C02 CTRP2; CCLE 1.4296 5.9672 1.029 32.0539
BHT-101 CTRP2 1.4834 4.2531 1.4175 30.606
8305C CTRP2; CCLE 1.5119 3.9191 1.428 25.5184
CGTH-W-1 GDSC1; CTRP2 1.648 2.843 1.6477 29.2903
FTC-238 CTRP2 2.0744 3.0512 2.0743 26.4492
8505C CTRP2; CCLE 2.1002 3.9609 2.0842 26.3303
CAL-62 CTRP2 2.4359 3.0863 2.4359 24.0404
FTC-133 CTRP2 4.3781 7.9219 3.5111 14.37
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -1.6471 1.3902 -1.6577 51.2311
BB30-HNC GDSC1 -0.4377 4.135 -1.8827 27.4517
LB771-HNC GDSC1 -0.1604 2.4017 -0.8058 19.0486
SNU-1214 CTRP2 -0.0271 3.7847 -0.1288 40.7261
BICR 31 CTRP2 0.2043 4.4899 0.0181 39.4251
SCC-4 CTRP2 0.3094 4.356 0.1526 38.6615
PE/CA-PJ49 CTRP2 0.638 4.0725 0.5426 36.3187
YD-8 CTRP2 0.6886 2.8657 0.6797 35.7105
SCC-25 CTRP2; CCLE 0.7354 3.7214 0.6818 35.5425
Hs 840.T CCLE 0.7846 3.884 0.2941 21.2996
BICR 18 CTRP2 0.7851 4.5763 0.6287 35.5305
PE/CA-PJ34 (clone C12) CTRP2 1.2106 3.9224 1.1624 32.3635
BICR 6 CTRP2 1.4282 2.9572 1.4264 30.7595
CAL-33 CTRP2 1.5715 3.9279 1.5389 29.9083
SNU-46 CTRP2 1.6231 3.1355 1.6136 24.4541
BHY CTRP2 1.6716 3.4574 1.6642 29.1567
SNU-1076 CTRP2 1.769 3.8411 1.749 28.5502
BICR 22 CTRP2 1.8282 3.8468 1.8097 28.1507
SNU-1041 CTRP2 1.8982 4.6302 1.8126 27.9112
CAL-27 CTRP2; CCLE 1.9604 4.0005 1.9378 27.2839
BICR 16 CTRP2 2.0894 3.2955 2.0886 26.3512
Detroit 562 CTRP2; CCLE 2.1054 4.6014 2.0367 26.4739
HSC-3 CTRP2 2.1082 3.4593 2.1061 26.2306
HSC-2 CTRP2; CCLE 2.2139 3.1552 2.2138 25.5196
PE/CA-PJ41 (clone D2) CTRP2 2.2318 3.4226 2.2308 25.4036
BB49-HNC GDSC1 2.3201 6.5654 -0.7743 9.6797
SNU-899 CTRP2 2.4111 3.086 2.4111 24.2053
PE/CA-PJ15 CTRP2 2.4171 3.9891 2.4081 24.1955
FaDu CTRP2; CCLE 2.4463 4.4162 2.4145 24.0778
HSC-4 CTRP2 2.4809 4.5964 2.4345 23.8972
SNU-1066 CTRP2 2.5025 3.8453 2.4988 23.609
BICR 56 CTRP2 2.632 5.279 2.4979 23.1923
SCC-9 CTRP2; CCLE 3.3561 4.6259 3.3451 17.9466
SCC-15 GDSC1 3.9413 5.8062 0.3985 0.3265
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2; CCLE -1.0741 0.9008 -1.0747 47.4255
UM-UC-1 CTRP2 -0.3096 8.7751 -1.7888 44.4956
RT-112 CTRP2; CCLE 0.083 2.3045 0.0774 39.7335
KMBC-2 CTRP2; CCLE 0.4395 4.6105 0.251 37.895
5637 CTRP2; CCLE 0.5108 2.904 0.4974 36.9093
SW780 CCLE 1.0071 3.9633 0.5028 19.4737
SCaBER CTRP2; CCLE 1.2576 3.9214 1.2117 32.0427
HT-1376 CTRP2; CCLE 1.2989 4.5731 1.1804 32.0078
TCCSUP CTRP2; CCLE 1.3456 3.6752 1.3207 31.387
U-BLC1 CTRP2 1.5769 3.2514 1.5726 29.7774
RT-4 CTRP2; CCLE 1.6523 3.5571 1.6414 29.297
BFTC-905 CTRP2 1.7569 2.9783 1.7564 28.5654
647V CTRP2 1.9611 3.4038 1.9585 27.2122
VM-CUB-1 CTRP2 1.9658 3.9111 1.9483 27.2307
HT-1197 CTRP2; CCLE 2.1852 4.2484 2.1548 25.8125
SW1710 CTRP2 2.3904 3.883 2.3841 24.3645
CAL-29 CTRP2 2.4358 4.1415 2.421 24.0905
BC-3C CTRP2 2.5286 3.0396 2.5286 23.423
J82 CTRP2; CCLE 2.6586 4.2619 2.6446 22.6035
639V CTRP2; CCLE 2.7077 3.7416 2.7069 22.2324
253J-BV CTRP2 2.7155 3.7384 2.7148 22.1801
UM-UC-3 CTRP2; CCLE 2.7932 4.6122 2.7612 21.7676
T24 CTRP2; CCLE 2.8837 4.1701 2.8785 21.0743
KU-19-19 CTRP2 2.91 4.8659 2.8588 21.0547
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -1.8541 0.6228 -2.0204 36.6082
NEC8 GDSC1 -1.451 2.6397 -2.2502 35.0125
SW954 GDSC1 -0.8928 3.3551 -1.9762 30.3626
LB831-BLC GDSC1 -0.8374 1.9906 -1.3418 26.2937
KGN GDSC1 -0.826 1.7781 -1.2486 25.6201
SW962 GDSC1 0.4511 5.5516 -1.7479 22.5972
NCC-IT GDSC1 0.8814 3.8132 -0.5066 12.2737
DSH1 GDSC1 1.6758 5.213 -0.5732 10.0729
TC-YIK GDSC1 2.2155 6.0146 -0.5809 8.5881
JAR GDSC1 2.8029 4.3399 0.489 0.6403
OMC-1 [Human cervical carcinoma] GDSC1 2.9054 4.9343 0.3031 1.3798
HeLa CTRP2 2.9475 5.1575 2.859 20.9332
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5714).
2 Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.
3 A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011 Sep 15;71(18):6051-60. doi: 10.1158/0008-5472.CAN-11-1340. Epub 2011 Jul 26.
4 Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells. Clin Cancer Res. 2012 Jul 1;18(13):3592-602. doi: 10.1158/1078-0432.CCR-11-2972. Epub 2012 May 2.
5 Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. doi: 10.1073/pnas.1019559108. Epub 2011 Apr 18.