Details of the Drug

General Information of Drug (ID: DMGC5AT)

Drug Name
cytosporone B
Synonyms dothiorelone G
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
Chemical Identifiers
Formula
C18H26O5
Canonical SMILES
CCCCCCCC(=O)C1=C(C=C(C=C1O)O)CC(=O)OCC
InChI
1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChIKey
UVVWQQKSNZLUQA-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10687292
ChEBI ID
CHEBI:95039
CAS Number
321661-62-5
TTD ID
D08NYN

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 7.0315 10.6482 3.6867 6.0987
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 5.5309 8.4813 3.7233 10.1465
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 4.9959 6.0058 4.532 5.0161
GaMG CTRP1 5.8847 7.7382 4.329 3.8422
LN-229 CTRP1 7.7212 15.2973 1.9522 15.808
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 CTRP1 4.2385 8.1919 2.7654 23.5212
HEC-6 CTRP1 4.3977 5.2318 4.2837 10.32
HEC-151 CTRP1 4.6246 5.4775 4.4294 7.7713
HEC-251 CTRP1 4.9323 6.1504 4.4044 6.4444
HEC-265 CTRP1 4.9851 6.3052 4.3732 6.4915
HEC-108 CTRP1 5.312 7.3434 4.1201 7.4644
HEC-59 CTRP1 5.6062 7.7486 4.1384 6.2804
JHUEM-2 CTRP1 5.9263 10.6918 2.9286 15.0831
KLE CTRP1 6.0692 8.6996 3.996 6.095
Ishikawa (Heraklio) 02 ER- CTRP1 4.7667 5.5963 4.5199 6.2193
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCI-AML-3 CTRP1 4.3729 5.3761 4.2048 11.1106
Ku812 CTRP1 4.4823 5.9142 4.0901 11.4526
BL-70 CTRP1 4.5062 5.4202 4.3294 9.2909
KE-97 CTRP1 4.5873 6.1026 4.1061 10.7602
KMS-11 CTRP1 4.7708 6.3878 4.1413 9.5444
LP-1 CTRP1 4.8491 9.9271 2.4478 22.7132
PL21 CTRP1 4.8798 6.7518 4.059 9.7782
HT CTRP1 4.8862 6.1613 4.3579 7.07
GDM-1 CTRP1 5.1378 7.0885 4.1091 8.2356
P3HR-1 CTRP1 5.1967 6.2823 4.5579 3.9764
EJM CTRP1 5.3581 8.0719 3.7939 10.1739
AMO1 CTRP1 5.476 6.6963 4.5563 3.067
SU-DHL-5 CTRP1 5.5059 6.751 4.5501 3.0323
THP-1 CTRP1 5.7226 8.002 4.097 6.2685
WSU-DLCL2 CTRP1 5.822 7.4139 4.4402 3.0966
NOMO-1 CTRP1 5.8573 7.6621 4.3472 3.7639
SKM-1 CTRP1 5.8961 9.867 3.3119 12.266
MC116 CTRP1 6.1932 7.1388 4.7454 0.4254
U-937 CTRP1 6.4009 13.5242 1.8859 20.0965
MOLM-16 CTRP1 6.6084 8.4806 4.4018 1.8297
RPMI-8226 CTRP1 6.6828 8.8765 4.2732 2.5575
NU-DUL-1 CTRP1 6.8668 26.8866 -4.3873 35.9925
OCI-Ly10 CTRP1 6.917 11.8077 3.0789 10.8726
SU-DHL-4 CTRP1 6.9223 8.0989 4.6795 0.2322
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 4.8866 6.2727 4.303 7.5606
RCC10RGB CTRP1 4.957 6.2635 4.3697 6.6467
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS513 CTRP1 3.4884 6.2029 2.9382 26.5814
SW48 CTRP1 3.8404 6.3176 3.2564 22.0161
COLO205 CTRP1 4.1022 5.4292 3.8946 15.2751
GP2d CTRP1 4.2225 5.424 4.0257 13.479
SNU-C2A CTRP1 4.5527 6.1873 4.0323 11.5835
DLD-1 CTRP1 4.66 5.4489 4.4784 7.1573
LS411N CTRP1 4.7104 5.5577 4.4816 6.8509
LS180 CTRP1 4.7335 5.467 4.5458 6.1751
SNU-C5 CTRP1 4.8956 5.9454 4.4732 5.9959
SW620 CTRP1 4.967 6.4458 4.2874 7.3428
COLO 320 CTRP1 5.007 6.7679 4.1608 8.31
CW-2 CTRP1 5.0689 6.3238 4.4348 5.5838
SNU-175 CTRP1 5.1484 7.7102 3.8071 10.8802
SNU-81 CTRP1 5.1735 7.0327 4.1658 7.5849
COLO 678 CTRP1 5.206 7.1969 4.1099 7.9592
KM12 CTRP1 5.2767 7.0345 4.2462 6.4703
SK-CO-1 CTRP1 5.2851 8.5928 3.4767 13.1742
SNU-61 CTRP1 5.2929 7.3132 4.1203 7.5345
SNU-C4 CTRP1 5.5221 6.7278 4.5717 2.8032
C2BBe1 CTRP1 5.6986 7.9744 4.0937 6.3719
HT-29 CTRP1 5.7072 8.727 3.7331 9.4443
NCI-H508 CTRP1 5.7076 8.2667 3.9582 7.513
RCM-1 [Human ESC] CTRP1 5.8001 7.7202 4.2836 4.4476
SW403 CTRP1 5.8365 9.1774 3.6062 10.0742
HCT 116 CTRP1 5.8589 8.0025 4.1885 5.0812
LS123 CTRP1 5.8842 7.9462 4.2314 4.6506
HT-55 CTRP1 5.9443 7.9432 4.2709 4.1629
HT115 CTRP1 6.0915 7.6277 4.4987 2.0541
HCT 8 CTRP1 6.1291 8.9424 3.9202 6.5535
SNU-1040 CTRP1 6.1833 8.0993 4.3419 3.0296
SW480 CTRP1 6.296 9.78 3.6326 8.4211
SW948 CTRP1 6.4403 7.6407 4.6588 0.5991
CL-34 CTRP1 6.4553 10.1302 3.5712 8.4538
RKO CTRP1 6.4822 8.4119 4.3673 2.2635
MDST8 CTRP1 6.7898 8.0099 4.6618 0.3437
CL-40 CTRP1 7.0192 8.4771 4.5819 0.4816
LoVo CTRP1 7.173 9.4975 4.2562 1.9187
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP1 4.7204 6.967 3.8098 12.7205
JHH-6 CTRP1 5.0418 6.0507 4.5487 4.6693
SNU-449 CTRP1 5.2293 7.0547 4.1992 7.0684
Hep-G2 CTRP1 6.3213 11.0633 3.0326 12.9899
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2029 CTRP1 3.1887 4.7994 3.0824 27.4918
NCI-H1048 CTRP1 3.5336 4.8658 3.4428 22.4599
NCI-H810 CTRP1 3.5749 4.8039 3.5012 21.7412
SHP-77 CTRP1 3.8266 5.4315 3.5966 19.3711
NCI-H1573 CTRP1 3.8433 5.4764 3.5987 19.2496
ChaGo-K-1 CTRP1 4.0103 5.5855 3.7374 17.1094
NCI-H2342 CTRP1 4.1451 5.1061 4.0483 13.7835
NCI-H1666 CTRP1 4.1923 5.0281 4.1213 12.9096
NCI-H1568 CTRP1 4.2086 5.771 3.8722 14.8289
NCI-H1355 CTRP1 4.3725 6.0981 3.8959 13.7143
Lu-99 CTRP1 4.3892 6.2242 3.8545 13.9802
VMRC-LCD CTRP1 4.4016 5.8901 4.0194 12.4976
DMS 273 CTRP1 4.4146 5.6836 4.1235 11.5415
NCI-H727 CTRP1 4.4304 6.0341 3.9832 12.6524
NCI-H2009 CTRP1 4.4969 5.9032 4.1097 11.2054
NCI-H23 CTRP1 4.5069 6.2717 3.9478 12.5562
Calu-6 CTRP1 4.523 5.5526 4.292 9.5064
NCI-H1299 CTRP1 4.5381 5.7404 4.225 9.9911
NCI-H2286 CTRP1 4.6026 5.3963 4.4406 7.8036
NCI-H1963 CTRP1 4.6225 9.268 2.5805 22.8877
COLO 668 CTRP1 4.635 6.2152 4.0982 10.587
NCI-H82 CTRP1 4.6526 5.9777 4.2287 9.3521
NCI-H841 CTRP1 4.6733 6.1611 4.1608 9.8451
HCC1833 CTRP1 4.686 5.696 4.3937 7.7413
HCC1359 CTRP1 4.6947 5.2391 4.6009 5.9357
NCI-H1876 CTRP1 4.695 6.1974 4.1639 9.7104
LC-1/sq-SF CTRP1 4.7051 5.1861 4.6318 5.621
NCI-H2405 CTRP1 4.7368 6.0444 4.2774 8.5001
NCI-H1373 CTRP1 4.7469 7.1791 3.7288 13.3072
NCI-H1836 CTRP1 4.7576 6.0229 4.3074 8.1326
HCC44 CTRP1 4.7638 6.7547 3.954 11.2426
NCI-H2081 CTRP1 4.7677 6.1675 4.2464 8.6244
NCI-H661 CTRP1 4.7861 7.1438 3.7812 12.6672
NCI-H1975 CTRP1 4.7966 6.078 4.3171 7.8569
NCI-H650 CTRP1 4.8013 5.9203 4.3984 7.1121
NCI-H1105 CTRP1 4.807 8.584 3.0822 18.4072
NCI-H1792 CTRP1 4.8074 5.6607 4.5292 5.928
NCI-H522 CTRP1 4.831 8.0722 3.3583 16.0839
COR-L88 CTRP1 4.8355 5.7509 4.5127 5.9321
NCI-H1944 CTRP1 4.8577 6.5997 4.115 9.3759
A-549 CTRP1 4.8622 6.1853 4.3244 7.4817
NCI-H1694 CTRP1 4.8792 6.0934 4.3852 6.8589
NCI-H1793 CTRP1 4.8897 6.4631 4.2113 8.3688
LXF 289 CTRP1 4.8978 6.2924 4.3032 7.5073
KNS-62 CTRP1 4.902 5.7662 4.5672 5.1261
EBC-1 CTRP1 4.9592 7.7173 3.6457 13.082
NCI-H1930 CTRP1 4.9773 7.5781 3.7306 12.2643
HARA [Human squamous cell lung carcinoma] CTRP1 4.9985 6.0374 4.5184 5.1267
NCI-H358 CTRP1 4.9986 7.6023 3.7366 12.1207
NCI-H1435 CTRP1 5.0037 6.1883 4.4476 5.7417
COR-L279 CTRP1 5.0476 6.4345 4.3617 6.3301
NCI-H2126 CTRP1 5.0645 5.8734 4.6563 3.6057
BEN CTRP1 5.0706 6.2625 4.4668 5.2875
COR-L51 CTRP1 5.1359 8.2414 3.5313 13.3186
HCC2935 CTRP1 5.1618 6.7753 4.2849 6.5614
CAL-12T CTRP1 5.1777 6.8235 4.2735 6.601
LCLC-97TM1 CTRP1 5.179 7.741 3.8165 10.6724
LCLC-103H CTRP1 5.1915 6.6455 4.3732 5.6519
NCI-H1437 CTRP1 5.197 6.928 4.2368 6.8554
HCC78 CTRP1 5.2448 7.8155 3.8323 10.2732
HCC33 CTRP1 5.2629 6.6197 4.4413 4.7768
NCI-H596 CTRP1 5.3047 7.0564 4.2568 6.2723
RERF-LC-KJ CTRP1 5.3258 6.8552 4.3724 5.1663
COLO 699 CTRP1 5.3359 8.5904 3.5183 12.6255
SCLC-21H CTRP1 5.3567 7.7633 3.9461 8.8428
NCI-H3255 CTRP1 5.3571 7.0401 4.3045 5.6597
NCI-H2141 CTRP1 5.4651 7.726 4.0469 7.5611
EPLC-272H CTRP1 5.4669 7.8932 3.9657 8.2681
NCI-H1781 CTRP1 5.4898 7.0174 4.4113 4.2755
HCC2108 CTRP1 5.5237 7.6454 4.1295 6.6317
NCI-H1915 CTRP1 5.5482 7.442 4.2464 5.5262
SK-LU-1 CTRP1 5.5686 7.2052 4.3751 4.3455
Calu-3 CTRP1 5.5758 7.5886 4.1947 5.8885
NCI-H2110 CTRP1 5.5804 8.3321 3.834 9.0165
HCC4006 CTRP1 5.5999 9.1861 3.427 12.3874
NCI-H441 CTRP1 5.6901 8.1849 3.9856 7.334
T3M-10 CTRP1 5.7801 7.9872 4.1434 5.6941
NCI-H2073 CTRP1 5.9715 8.0789 4.2247 4.4705
Sq-1 CTRP1 6.0333 7.5864 4.485 2.2691
NCI-H2023 CTRP1 6.0731 10.2953 3.2303 12.3077
Lu-65 CTRP1 6.0974 8.6385 4.0428 5.6303
NCI-H1755 CTRP1 6.1217 7.939 4.3784 2.885
HCC1195 CTRP1 6.1665 8.5613 4.1221 4.8005
HCC827 CTRP1 6.1686 8.7351 4.0427 5.44
NCI-H2172 CTRP1 6.4027 7.9966 4.5013 1.51
NCI-H2030 CTRP1 6.403 9.4507 3.8565 6.3261
DV-90 CTRP1 6.4555 8.9204 4.1304 4.046
NCI-H460 CTRP1 6.4618 8.688 4.2371 3.231
COR-L23 CTRP1 6.5226 8.0477 4.5369 1.1357
HCC15 CTRP1 6.6206 9.4536 3.9862 4.7775
NCI-H2122 CTRP1 6.9853 9.4092 4.202 2.5287
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CTRP1 4.5288 5.6352 4.2622 9.7248
KYSE-410 CTRP1 4.9045 6.0843 4.4124 6.4984
KYSE-450 CTRP1 4.9376 7.3846 3.7935 11.8839
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVKATE CTRP1 4.169 6.1224 3.6791 16.6747
OVCAR-4 CTRP1 4.2605 6.0693 3.7959 15.1803
HEY A8 CTRP1 4.321 6.2061 3.7949 14.8568
COV434 CTRP1 4.3573 5.4497 4.1598 11.572
SK-OV-3 CTRP1 4.6209 5.6115 4.3668 8.3243
OVCAR-8 CTRP1 4.6894 6.7291 3.8989 12.0815
COV318 CTRP1 5.0794 6.2965 4.4571 5.3392
RMUG-S CTRP1 5.0903 9.1613 3.0337 17.5352
JHOM-1 CTRP1 5.2921 6.5635 4.491 4.2304
OV-90 CTRP1 5.3982 6.6248 4.5375 3.4671
OAW42 CTRP1 5.5529 7.0414 4.443 3.8088
OVK18 CTRP1 5.563 11.3797 2.3081 20.6256
JHOS-4 CTRP1 5.5718 7.9112 4.0343 7.3027
OVMANA CTRP1 5.6706 7.3674 4.366 4.1201
A2780 CTRP1 5.8039 8.8579 3.7388 9.0712
JHOC-5 CTRP1 5.8184 7.7134 4.2986 4.2712
COV644 CTRP1 5.866 7.3032 4.5166 2.3876
COV362 CTRP1 5.8914 7.7528 4.3263 3.8466
TYK-nu CTRP1 5.9601 8.0688 4.2223 4.5214
EFO-27 CTRP1 6.0043 8.25 4.1656 4.8704
EFO-21 CTRP1 6.0158 8.613 4.002 6.1962
Caov-3 CTRP1 6.0223 8.0114 4.2873 3.8315
RMG-I CTRP1 6.1369 10.4315 3.2093 12.259
SNU-840 CTRP1 6.156 9.4265 3.7079 8.2228
IGROV-1 CTRP1 6.8742 12.1206 2.9022 12.2449
OV7 CTRP1 7.1705 8.8672 4.499 0.6938
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-3 CTRP1 4.2049 7.3611 3.1366 20.9333
HuP-T4 CTRP1 4.5167 5.6545 4.2413 9.97
QGP-1 CTRP1 4.5796 6.4221 3.9458 12.2041
Capan-2 CTRP1 4.7342 6.7322 3.9383 11.5206
Panc 10.05 CTRP1 5.1676 6.6663 4.3439 6.0074
HPAC CTRP1 5.2572 7.1833 4.1571 7.3398
CFPAC-1 CTRP1 5.2618 6.7242 4.3888 5.2499
PaTu 8902 CTRP1 5.3069 6.4277 4.5686 3.4921
Panc 03.27 CTRP1 5.8855 8.4865 3.9754 6.8048
SUIT-2 CTRP1 6.1692 11.2198 2.8476 14.8283
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 4.2748 6.8917 3.4284 18.2062
NCI-H28 CTRP1 4.6435 6.6858 3.8777 12.4881
NCI-H2052 CTRP1 5.1963 6.5946 4.4023 5.3723
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 4.8428 6.1909 4.3041 7.7531
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 852.T CTRP1 4.6268 5.5896 4.3826 8.1565
Hs 936.T CTRP1 4.8772 5.4781 4.6837 4.2168
Hs 944.T CTRP1 5.1624 7.4223 3.9623 9.4487
G-361 CTRP1 5.6451 7.7875 4.1469 6.0814
COLO 741 CTRP1 5.789 8.6604 3.8244 8.3933
A-375 CTRP1 5.9705 8.1718 4.1808 4.8361
SK-MEL-28 CTRP1 6.0923 6.975 4.7653 0.4224
SK-MEL-5 CTRP1 6.427 7.9586 4.5284 1.3089
SK-MEL-1 CTRP1 6.6561 8.7991 4.2923 2.4738
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 4.4678 7.4129 3.3591 17.7953
RKN CTRP1 5.0536 6.3219 4.423 5.7536
HT-1080 CTRP1 6.0678 8.3561 4.1561 4.78
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP1 4.9153 5.6193 4.6516 4.3124
NUGC-4 CTRP1 5.1429 6.7755 4.2695 6.7736
MKN7 CTRP1 5.2666 7.6009 3.9566 9.0909
MKN74 CTRP1 5.3965 7.3623 4.175 6.67
Fu97 CTRP1 5.4599 7.519 4.1449 6.7143
SH-10-TC CTRP1 6.2922 8.4245 4.2588 3.4254
SNG-M CTRP1 5.923 9.0425 3.7332 8.7308
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 4.5848 5.6724 4.3029 9.0688
SCC-9 CTRP1 5.5084 6.9172 4.4724 3.6898
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 CTRP1 3.4554 7.0864 2.5231 29.6067
HT-1376 CTRP1 4.0566 8.3564 2.5151 26.1675
KMBC-2 CTRP1 4.8663 6.9528 3.947 10.8378
UM-UC-3 CTRP1 4.9905 7.2764 3.8926 10.7786
5637 CTRP1 5.1088 6.7288 4.2651 6.9492

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5424).